Refine
Year of publication
- 2019 (644) (remove)
Document Type
- Journal article (435)
- Doctoral Thesis (163)
- Book article / Book chapter (23)
- Preprint (19)
- Conference Proceeding (1)
- Other (1)
- Report (1)
- Working Paper (1)
Language
- English (644) (remove)
Keywords
- Animal Studies (24)
- Cultural Animal Studies (24)
- Cultural Studies (24)
- Ecocriticism (24)
- Environmental Humanities (24)
- Human-Animal Studies (24)
- Literary Studies (24)
- boron (11)
- apoptosis (8)
- Tissue Engineering (6)
- inflammation (6)
- ischemic stroke (6)
- cancer (5)
- measles virus (5)
- DNA methylation (4)
- Drosophila melanogaster (4)
- Hydrogel (4)
- Maschinelles Lernen (4)
- Neisseria meningitidis (4)
- Spektroskopie (4)
- Taufliege (4)
- cancer therapy (4)
- children (4)
- deep brain stimulation (4)
- infection (4)
- multiple myeloma (4)
- sphingolipids (4)
- tissue engineering (4)
- virtual reality (4)
- Übergangsmetalloxide (4)
- 3D tissue model (3)
- 3D-Druck (3)
- Ancistrocladaceae (3)
- Candida albicans (3)
- Chronobiologie (3)
- Elektrophysiologie (3)
- Exziton (3)
- Fluoreszenzmikroskopie (3)
- GABA (3)
- Genexpression (3)
- Leistungsbewertung (3)
- Maus (3)
- Megakaryozyt (3)
- Meningitis (3)
- Monte-Carlo (3)
- Physics (3)
- Raman-Spektroskopie (3)
- Schlaganfall (3)
- Serotonin (3)
- Soziale Wahrnehmung (3)
- Staphylococcus aureus (3)
- Survival (3)
- Ureaplasma parvum (3)
- Ureaplasma urealyticum (3)
- aging (3)
- blood–brain barrier (3)
- boranes (3)
- climate change (3)
- colorectal cancer (3)
- cytokines (3)
- cytotoxicity (3)
- death receptors (3)
- epigenetics (3)
- genetics (3)
- gephyrin (3)
- in vitro (3)
- length of stenosis (3)
- leukemic cells (3)
- lysosome (3)
- machine learning (3)
- metagenomics (3)
- microbiome (3)
- p53 (3)
- presence (3)
- psychiatric disorders (3)
- remote sensing (3)
- stem cells (3)
- ubiquitin (3)
- 2Dimensionale Spektroskopie (2)
- 3D (2)
- 3D printing (2)
- AdS/CFT (2)
- Aggregation (2)
- Angst (2)
- Annotation (2)
- Anxiety (2)
- Aufmerksamkeit (2)
- B-MYB (2)
- Bees (2)
- Bilanzpolitik (2)
- Bildverarbeitung (2)
- Bioinformatik (2)
- Biomaterial (2)
- Biomedical engineering (2)
- Blutgerinnung (2)
- C-reactive protein (2)
- CXCR4 (2)
- Cancer (2)
- Channelrhodopsin (2)
- Chlamydia trachomatis (2)
- Colonization (2)
- Constraints (2)
- Cross-Section (2)
- Cryo-EM (2)
- DNA damage (2)
- Decay (2)
- Deutschland (2)
- Drosophila (2)
- EEA (2)
- Ecology (2)
- Exercise capacity (2)
- Expression (2)
- FKBP5 (2)
- GABAA receptors (2)
- Gedächtnis (2)
- HBMEC (2)
- HBV (2)
- HIV (2)
- Hadron colliders (2)
- Halbleiter (2)
- HeLa cells (2)
- Imaging techniques (2)
- Impact (2)
- Implantat (2)
- In vitro (2)
- Inhibitor (2)
- KDELR2 (2)
- Kernspintomografie (2)
- Knochenzement (2)
- Kognition (2)
- Lungenkrebs (2)
- MSC (2)
- Machine Learning (2)
- Melanoma (2)
- Merocyanine (2)
- Metabolomics (2)
- Metadynamics (2)
- Methylation (2)
- Mitose (2)
- Molekulargenetik (2)
- Muscarinrezeptor (2)
- NHC (2)
- Naphthylisochinolinalkaloide (2)
- Neural circuits (2)
- Neurons (2)
- Optimierung (2)
- Optogenetik (2)
- PIP2 (2)
- Pair Production (2)
- Parton Distributions (2)
- Parton distributions (2)
- Perylenderivate (2)
- Pontryagin maximum principle (2)
- Positronen-Emissions-Tomografie (2)
- Quanten-Vielteilchensysteme (2)
- Quantum Information (2)
- Quantum many-body systems (2)
- RNA-seq (2)
- Radiative-corrections (2)
- Reduction (2)
- Regenerative Medizin (2)
- Röntgen-Photoelektronenspektroskopie (2)
- S-ADAPT (2)
- SQH method (2)
- Screening (2)
- Selbstorganisation (2)
- Sentinel-1 (2)
- Signaltransduktion (2)
- Simulation (2)
- Solution-state NMR (2)
- Stem cells (2)
- Supramolekulare Chemie (2)
- TNF receptor superfamily (2)
- TNF superfamily (2)
- TNFR1 (2)
- TRAIL (2)
- Tanzania (2)
- Telekommunikationsnetz (2)
- Thrombozyt (2)
- Top-Quark (2)
- VEGF (2)
- Vaskularisierung (2)
- Verhalten (2)
- Zellteilung (2)
- adolescents (2)
- allometric scaling (2)
- antibiotics (2)
- antibody (2)
- antibody fusion proteins (2)
- artemisinin (2)
- autophagy (2)
- bacteria (2)
- biofabrication (2)
- blood-brain barrier (2)
- body composition (2)
- body size (2)
- bone (2)
- bone adhesive (2)
- cAArC (2)
- calcium phosphate cement (2)
- cardiomyopathy (2)
- carotid atherosclerosis (2)
- carotid stenosis (2)
- carotid ultrasound (2)
- caspase-8 (2)
- cell death (2)
- cell imaging (2)
- cell therapy (2)
- chemistry (2)
- complexes (2)
- copper (2)
- cystic fibrosis patients (2)
- dSTORM (2)
- degree of stenosis (2)
- dendritic cells (2)
- density functional calculations (2)
- depression (2)
- diazepam (2)
- dopamine (2)
- drug delivery (2)
- ecology (2)
- endothelium (2)
- evolution (2)
- exciton-exciton (2)
- fluorescence (2)
- genome annotation (2)
- genome assembly (2)
- geomorphology (2)
- glioblastoma multiforme (2)
- glucocorticoid receptor (2)
- healthy volunteers (2)
- hydroboration (2)
- hydrogel (2)
- immunotherapy (2)
- information extraction (2)
- inhibitory neurotransmission (2)
- interleukin-8 (2)
- irradiation (2)
- knockout (2)
- macrophages (2)
- magnetic resonance imaging (2)
- measurement (2)
- megakaryopoiesis (2)
- melt electrospinning writing (2)
- meningitis (2)
- mental health (2)
- mesencephalic locomotor region (2)
- metabolic adaptation (2)
- migration (2)
- mitochondria (2)
- mouse (2)
- multiple bonding (2)
- multiple sclerosis (2)
- natural language processing (2)
- neuroinflammation (2)
- neurology (2)
- neuroprotection (2)
- next generation sequencing (2)
- oncolytic virus (2)
- optimal drug combination (2)
- optogenetics (2)
- outcome (2)
- pathogens (2)
- performance (2)
- personalized medicine (2)
- photothrombotic stroke (2)
- platelets (2)
- polycyclic aromatic hydrocarbons (2)
- polymers (2)
- population pharmacokinetics (2)
- prostate cancer (2)
- radicals (2)
- reactive oxygen species (2)
- recurrence (2)
- relapse (2)
- rheumatoid arthritis (2)
- ring-expansion reaction (2)
- risk factors (2)
- screening (2)
- secondary prevention (2)
- smartphone app (2)
- social attention (2)
- stroke (2)
- structure (2)
- subthalamic nucleus (2)
- surgery (2)
- survival (2)
- synthesis (2)
- targeted therapy (2)
- tight junction (2)
- trade-offs (2)
- two-photon excited fluorescence (2)
- wound healing (2)
- (classical and atypical) Werner syndrome (1)
- (hem)ITAM signaling (1)
- + (1)
- ++ (1)
- 1,2-additions (1)
- 18F-FDS (1)
- 2 Jets (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 25-hydroxycholesterol 7 alpha-hydroxylase (1)
- 2D material (1)
- 3-coordinate organoboron compounds (1)
- 3D Bioprinting (1)
- 3D Modell (1)
- 3D Point Cloud Processing (1)
- 3D Tumormodell (1)
- 3D cultures (1)
- 3D model (1)
- 3D remote sensing (1)
- 3D tumour model (1)
- 3D-Modell (1)
- 3 T (1)
- 4-HNE (1)
- 4D flow (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATOC (1)
- A-D-A dyes (1)
- A-priori-Wissen (1)
- A. abbreviatus (1)
- A. likoko (1)
- ABP1 (1)
- ADHD (1)
- AHRR (1)
- ALAN (1)
- AMP-activated kinases (1)
- AMP‐activated protein kinase (1)
- APOBEC3G (1)
- APRI (1)
- ARCI (1)
- ARCI EM type III (1)
- ATP generation (1)
- AUX1 (1)
- Abfallbehandlung (1)
- Abfallwirtschaft (1)
- Absorbed Doses (1)
- Abszision (1)
- Accurate (1)
- Acids (1)
- Ackerschmalwand (1)
- Actin (1)
- Actin-bindende Proteine (1)
- Activation (1)
- Active Galactic Nuclei (1)
- Active disease (1)
- Acute myeloid leukemia (AML) (1)
- AdS-CFT Correspondence (1)
- AdS-CFT-Korrespondenz (1)
- AdS/CFT correspondence (1)
- Adaptation (1)
- Adherens junction (1)
- Adhesion GPCR (1)
- Adipositas (1)
- Administered Activities (1)
- Adolescent (1)
- Adult (1)
- Advanced Analytics (1)
- Affekt (1)
- African Trypanosomiasis (1)
- Akt (1)
- Akt/PKB (1)
- Aktionsforschung (1)
- Alcohol dependence (1)
- Algorithm (1)
- Alien limb syndrome (1)
- Alkaloid (1)
- Allogeneic transplantation (1)
- Alpine habitats (1)
- Alzheimer's disease (1)
- Aminerge Nervenzelle (1)
- Amygdala (1)
- Anarchic limb syndrome (1)
- Andalusian varieties (1)
- Angiogenese (1)
- Angstverarbeitung (1)
- Animales Nervensystem (1)
- Anisotropic Magnetoresistance (1)
- Anomalous magnetic-moment (1)
- Anreize (1)
- Antarctica (1)
- Anthropocene (1)
- Anti-infective (1)
- Antibiotikum (1)
- Antigen CD19 (1)
- Antigen CD28 (1)
- Antigenrezeptor (1)
- Antikörper (1)
- Antimalariamittel (1)
- Antioxidants (1)
- Antizipation (1)
- Aortic arch (1)
- Apidae (1)
- Apis mellifera (1)
- Aplastic anemia (1)
- Apoptosis (1)
- Applied physics (1)
- Arabidopsis thaliana (1)
- Arbeitsmobilität (1)
- Archaeology (1)
- Aromatically annulated triquinacenes (1)
- Aromatisch anellierte Triquinacene (1)
- Arylborylene Complexes (1)
- Arzneimittel (1)
- Ascaris lumbricoides (1)
- Aspergillus (1)
- Aspergillus fumigalus (1)
- Assistenzbedarf (1)
- Associative learning (1)
- Astronomie (1)
- Astrophysical neutrino sources (1)
- Astroteilchenphysik (1)
- Atacama (1)
- Atmospheric muons (1)
- Atomic and molecular interactions with photons (1)
- Atrial fibrillation (1)
- Attitude Determination and Control (1)
- Attitude Dynamics (1)
- Audit Quality (1)
- Audit sampling (1)
- Aufsichtsrat (1)
- Autoaggressionskrankheit (1)
- Autologous hematopoietic stem cell transplantation (1)
- Autoproteolysis (1)
- Auxine (1)
- Außenhandel (1)
- B cell malignancies (1)
- B cells (1)
- B,N-heterocylcles (1)
- B-B bond activation (1)
- B7-H1 (1)
- BAL (1)
- BCG (1)
- BMI (1)
- BRAF mutation (1)
- BRAF-mutant (1)
- BRAF-mutiert (1)
- BRCA1 (1)
- BaBiO3 (1)
- Bank (1)
- Banking (1)
- Barrier (1)
- Behaviour (1)
- Behavioural ecology (1)
- Benchmarking (1)
- Benutzeroberfläche (1)
- Benzimidazole (1)
- Berberine (1)
- Berechnung (1)
- Berufsbildung (1)
- Bevacizumab (1)
- Bhabha Scattering (1)
- Big Data (1)
- Bildbearbeitung (1)
- Bildgebung intakten Knochens (1)
- Bildungswesen (1)
- Binge drinking (1)
- Biofabrication (1)
- Biofabrikation (1)
- Biofilm (1)
- Biofilmarchitektur (1)
- Bioink (1)
- Biokinetics (1)
- Biologika (1)
- Biomarke (1)
- Biomedicine (1)
- Biophysics (1)
- Bioreaktor (1)
- Biotinten (1)
- Bioverfügbarkeit (1)
- Bipolar disorder (1)
- Biradikal (1)
- Bistability (1)
- Black Holes in String Theory (1)
- Black holes (1)
- Black-hole (1)
- Blazar (1)
- Blood (1)
- Body schema (1)
- Boson (1)
- Bosons (1)
- Brain cancer (1)
- Brain diseases (1)
- Brain endothelial cells (1)
- Branching fractions (1)
- Bronchopulmonary dysplasia (1)
- Brustkrebs (1)
- Business Process Management (1)
- Business Process Modeling (1)
- By-Light Scattering (1)
- B−H activation (1)
- C-60 fullerene (1)
- C-C coupling (1)
- C/EBP (1)
- C3a (1)
- C3aR (1)
- C5a (1)
- C5aR1 (1)
- C5aR2 (1)
- C60 fullerene (1)
- CAR T cells (1)
- CCI (1)
- CD274 (1)
- CD4+ T cells (1)
- CD8+ T cells (1)
- CD95 (1)
- CDC42 (1)
- CERN (1)
- CIDP (1)
- CMV (1)
- CO sensing (1)
- CO‐releasing molecules (CORMs) (1)
- CRH1 (1)
- CRMO (1)
- CXCL5 (1)
- CXCL8 (1)
- CXCR2 (1)
- CYP1B1 (1)
- C\(_{60}\) fullerene (1)
- Cadherine (1)
- Caenorhabditis elegans (1)
- Calcium (1)
- Calciumphosphat (1)
- Calciumphosphate (1)
- Calciumphosphatzemente (1)
- Callyspongia siphonella (1)
- Cancer Cell (1)
- Cancer genetics (1)
- Capicua transcriptional repressor (1)
- Capillary Electrophoresis (1)
- Cardiac ventricles (1)
- Cardiovascular diseases (1)
- Cardiovascular risk factors (1)
- Cardiovascular risk prediction (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Carotisstenose (1)
- Caspase (1)
- Cataglyphis (1)
- Cdh13 (1)
- Cell migration (1)
- Cell stainin (1)
- Cellular neuroscience (1)
- Central Asia (1)
- Central nervous system (1)
- Ceramic polymer composite (1)
- Chambers (1)
- Channelrhodopsin-2 (1)
- Characterization and analytical techniques (1)
- Charge carrier recombination (1)
- Charge-transfer-Komplexe (1)
- Chelatbildner (1)
- Chemical Structure (1)
- Chemical composition (1)
- Chemical stability (1)
- Chemische Synthese (1)
- Cherenkov underwater neutrino telescope (1)
- Children (1)
- Chile (1)
- Chili RNA Aptamer (1)
- Chimeric Antigen Receptor (1)
- Chimärer Antigenrezeptor (1)
- China (1)
- Chiral spin liquids (1)
- Chirale Spinflússigkeiten (1)
- Choice Behavior/physiology (1)
- Chondrogenesis (1)
- Chromatographie (1)
- Chronische Nierenerkrankung (1)
- Chronobiology (1)
- Circinella (1)
- Circular dichroism (1)
- Click Chemie (1)
- Clinical Data Warehouse (1)
- Clinically silent stroke (1)
- CoQ10 (1)
- Code Examples (1)
- Codon (1)
- Cognitive behavior (1)
- Cognitive neuroscience (1)
- Coherent Multidimensional Spectroscopy (1)
- Community-acquired methicillin-resistant Staphylococcus aureus (1)
- Commuting (1)
- Complexity (1)
- Computational Chemistry (1)
- Computational and Systems Biology (1)
- Computed axial tomography (1)
- Computer modelling (1)
- Computersimulation (1)
- Conditioning regimen (1)
- Confidence intervals (1)
- Confocal microscopy (1)
- Conformal Metrics (1)
- Congolese Ancistrocladus plants (1)
- Conical Intersections (1)
- Conifers (1)
- Conservation (1)
- Consistent partial least squares (1)
- Construct Modeling (1)
- Controlling (1)
- Corporate Governance (1)
- Corporate Social Responsibility (1)
- Correlated Electron Materials (1)
- Correlated Fermions (1)
- Corticobasal syndrome (1)
- Corticosteroids (1)
- Cosmic-rays (1)
- Couplings (1)
- CpG (1)
- Cranial sutures (1)
- Cross-section (1)
- Curvature Equation (1)
- Cushing-Syndrom (1)
- Cushing’s disease (1)
- Cutaneous lymphoma (1)
- Cysteinproteasen (1)
- Cystic fibrosis (1)
- Cytochrome P 450 pathway (1)
- Cytokine (1)
- Cytologie (1)
- Cytosol (1)
- DC gate (1)
- DCAF17 (1)
- DEM (1)
- DFT mechanism (1)
- DLS and AFM measurements (1)
- DNA electronic transport (1)
- DNA methyltransferases (1)
- DNA repair (1)
- DNA sequencing (1)
- DNA weight (1)
- DNA-Schäden (1)
- DNA-repair (1)
- DNA-repair genes (1)
- DPP IV (1)
- DRG (1)
- DROSHA (1)
- DSB focus substructure (1)
- DSM (1)
- Dark-Matter (1)
- Dark-matter (1)
- Data Analytics (1)
- Data Warehouse (1)
- Data acquisition (1)
- Data-Warehouse-Konzept (1)
- Decision Support (1)
- Declarative Performance Engineering (1)
- Deep Inelastic-scattering (1)
- Delbruck Scattering (1)
- Demokratische Republik Kongo (1)
- Dendritic cell (1)
- Dendritische Zelle (1)
- Densovirus (1)
- Dental Phobia (1)
- Depression (1)
- Design (1)
- Development (1)
- Developmental biology (1)
- Dezellularisierung (1)
- Diabetes mellitus (1)
- Diagnosis prediction (1)
- Diagnostic Imaging Exams (1)
- Diagnostic medicine (1)
- Dickdarmtumor (1)
- Diffusion tensor imaging (1)
- Dihydroboranes (1)
- Disease severity (1)
- Dopamin (1)
- Dopamine (1)
- Dosimetry (1)
- Dosis (1)
- Dotierung (1)
- Double-Beta Decay (1)
- Doxorubicin (1)
- Drug delivery platforms (1)
- Drug discovery (1)
- Drug resistance (1)
- Drug testing (1)
- Dual setting system (1)
- Dynamical Systems (1)
- Dynamical system (1)
- Dynamics (1)
- Dünne Schicht (1)
- Dünnschichten (1)
- E(+)E(-) collicions (1)
- E-Learning (1)
- E2 conjugating enzyme (1)
- E3 ligating enzyme (1)
- E8 symmetry (1)
- EBF1 (1)
- ER-Stress (1)
- ERK (1)
- ERK signaling (1)
- ERK1/2 (1)
- ESAT‐6‐like secretion system (1)
- ESS (1)
- EUROASPIRE (1)
- EWAS (1)
- Earnings Management (1)
- Earnings Quality (1)
- Earnings management (1)
- Earth observation (1)
- Echinococcosis (1)
- Echinococcus (1)
- Efficiency (1)
- Efficiency Gains (1)
- Effizienzsteigerung (1)
- Efflux transport (1)
- Eierstockkrebs (1)
- Eigenvectors (1)
- Einkommensverteilung (1)
- Einwandige Kohlenstoff-Nanoröhre (1)
- Einzelmolekülmikroskopie (1)
- Elderly (1)
- Electrical impedance tomography (1)
- Electromagnetic signals (1)
- Electromagnon (1)
- Electron (1)
- Electrophysiology (1)
- Electrospinning (1)
- Electroweak Measurements (1)
- Electroweak Phase-Transition (1)
- Electroweak interaction (1)
- Elektrizitätsverbrauch (1)
- Elektromagnon (1)
- Elektron-Phonon-Wechselwirkung (1)
- Elektronentransfer (1)
- Elektrospinnen (1)
- Elissen-Palm flux (1)
- Embryonic induction (1)
- Embryos (1)
- Emergence (1)
- Emotionales Verhalten (1)
- Empirical Analysis (1)
- Enantiomerentrennung (1)
- Endogene Rhythmik (1)
- Endoplasmic-Reticulum Stress (1)
- Endothel (1)
- Energieeffizienz (1)
- Energy (1)
- Energy Efficiency (1)
- Enhancer elements (1)
- Entanglement (1)
- Entscheidungsunterstützung (1)
- Entscheidungsunterstützungssystem (1)
- Entwicklung (1)
- Entzündung (1)
- Environmental impact (1)
- Epidemiology (1)
- Epigenetic (1)
- Epigenetic regulation (1)
- Epitaxy (1)
- Epstein-Barr virus-induced gene 2 (1)
- Equipment (1)
- Erfolgsplanung (1)
- EsaA (1)
- Escherichia coli (1)
- European Organization for Nuclear Research. ATLAS Collaboration (1)
- European Spanish (1)
- European group (1)
- Event builder (1)
- Events GW150914 (1)
- Evolutionary developmental biology (1)
- Evolutionary emergence (1)
- Excited state dynamics (1)
- Exciton (1)
- Exciton coupling (1)
- Exciton localization dynamics (1)
- Exercise testing (1)
- Experimental Studies (1)
- Experimentelle Psychologie (1)
- Expiry date (1)
- Explosives (1)
- Explosivstoff (1)
- Extensions of gauge sector (1)
- Extracellular matrix (1)
- Extracellular volume (1)
- Extramedullary disease (1)
- Extrazelluläre Matrix (1)
- Extreme flows (1)
- Exziton-Polariton (1)
- Exzitonenkopplung (1)
- Eye Movements/physiology (1)
- Eye development (1)
- FIB-4 (1)
- Face Voice Matching (1)
- Fahrerassistenzsystem (1)
- Fak regulation (1)
- Familial Beckwith-Wiedemann syndrome (1)
- Farbstoff (1)
- FasL (1)
- Fatigue (1)
- Fats (1)
- Fear Generalization (1)
- Fear Learning (1)
- Fear conditioning (1)
- Female (1)
- Fertigarzneimittel (1)
- Festkörperphysik (1)
- Fgf-signalling (1)
- Fibroblastenwachstumsfaktor (1)
- Finite support distributions (1)
- Flavor Violation (1)
- Fliegenkippen (1)
- Flowering plants (1)
- Flowers (1)
- Fludarabine (1)
- Fludarabine-treosulfan (FT) (1)
- Fluorescence spectroscopy (1)
- Fluoreszenzspektroskopie (1)
- Fluorine (1)
- Fluorverbindungen (1)
- Flüssigkristall (1)
- Forces (1)
- Forests (1)
- Fotochemie (1)
- Fotophysik (1)
- Fourier-Spektroskopie (1)
- Fractional cover analysis (1)
- Fractional quantum Hall effect (1)
- Fraktionaler Quanten-Hall-Effekt (1)
- Full body ownership illusion (1)
- Functional Connectivity (1)
- Funktionalisierung <Chemie> (1)
- Funktionalisierung von elektrogesponnenen Fasern (1)
- Funktionelle Konnektivität (1)
- Furchkonditionierung (1)
- Furcht (1)
- Furchtgeneralisierung (1)
- Fusarium (1)
- G Protein-coupled receptor (1)
- G-2 (1)
- G-Protein gekoppelte Rezeptor (1)
- G-quadruplex (1)
- GABAA (1)
- GAD1 (1)
- GRP78 (1)
- GSV (1)
- GVHD (1)
- Ga-68-labelled Peptides (1)
- Galactic sources (1)
- Gallensalze (1)
- Gas chromatography (1)
- Gaseous detectors (1)
- Gauge bosons (1)
- Gauge-gravity correspondence (1)
- Gauge/Gravity Duality (1)
- Gaussian approximation (1)
- Gelatine (1)
- Gen-Umwelt Interaktion (1)
- Gene by Environment (1)
- Gene expression analysis (1)
- Gene silencing (1)
- General anaesthesia (1)
- Generalisierung (1)
- Generalisierung <Kartografie> (1)
- Generation (1)
- Genetik (1)
- Genmutation (1)
- Genom (1)
- Genome (1)
- Genome Annotation (1)
- Genomics (1)
- Genotype (1)
- Geriatric care (1)
- Geriatrics (1)
- Germany (1)
- Germline (1)
- Gesicht (1)
- Gestational diabetes (1)
- Gestationsdiabetes (1)
- Getz Ice Shelf (1)
- Gitterdynamik (1)
- Gliazelle (1)
- Glioblastoma (1)
- Glutathione (1)
- Glycidol (1)
- Glycoengineering (1)
- Glykane (1)
- Glykosylierung (1)
- Google Earth Engine (1)
- Governance (1)
- Graft versus host disease (1)
- Graph (1)
- Gravitons (1)
- Greenland ice sheet (1)
- Grenzfläche (1)
- Grenzflächenleitfähigkeit (1)
- Group B Streptococcus (1)
- Grundlagenforschung (1)
- Gruppo-italiano (1)
- GvHD (1)
- Gyrasehemmer (1)
- H-infinity (1)
- HARPES (1)
- HCV (1)
- HDAC (1)
- HEMA (1)
- HNE (1)
- HNSCC (1)
- HPA axis (1)
- HPLC (1)
- HRQOL (1)
- Hadron-Hadron scattering (experiments) (1)
- Hadron-hadron interactions (1)
- Haemophilus influenzae (1)
- Hard X-ray Angle Resolved Photoemission (1)
- Haut (1)
- Health (1)
- Heart (1)
- Heart failure (1)
- Helicasen (1)
- Hematopoietic Stem (1)
- Hematopoietic cell transplant (1)
- Heme-regulated inhibitor (1)
- Hemipelvectomy (1)
- Herzmuskelzelle (1)
- Heterosolarzelle (1)
- Heterostruktur (1)
- Hfq (1)
- Higgy-Boson (1)
- High grade glioma (1)
- High-Energies (1)
- High-Z Oxides (1)
- High-energy astrophysics (1)
- Hindbrain (1)
- Hippo pathway (1)
- Hippocampus (1)
- Histone deacetylase (1)
- Hochauflösende Fluoreszenzmikroskopie (1)
- Hodgkin lymphoma (1)
- Holstein model (1)
- Holstein-Modell (1)
- Honey bees (1)
- Hordeum vulgare (1)
- Hormontransport (1)
- Host Genome Integrity (1)
- Host-parasite interaction (1)
- Human Body Weight (1)
- Human Herpesvirus 6 (1)
- Human Muse Cells (1)
- Human behaviour (1)
- Human-Computer Interaction (1)
- Humanes Herpesvirus 6 (1)
- Humangenetik (1)
- Humans (1)
- Hunsrueck (1)
- Hurwitz theorem (1)
- Hyaluronic Acid (1)
- Hyaluronsäure (1)
- Hybrid Dynamical Systems (1)
- Hybridsystem (1)
- Hydrocarbon radicals (1)
- Hydrocarbons (1)
- Hydrogen (1)
- Hyperosmotic Stress (1)
- Hypothalamus (1)
- Hypothetical gauge bosons (1)
- Hypoxia (1)
- Hypoxie (1)
- IFN (1)
- IL-10 (1)
- IP3 (1)
- Icecube (1)
- Ideomotor Theory (1)
- Ideomotorik (1)
- Image Processing (1)
- Imatinib (1)
- Immune system (1)
- Immune-related adverse event (1)
- Immunologe (1)
- Immunology (1)
- Immunoprecipitation (1)
- Immuntherapie (1)
- Imo Bundesstaat (1)
- Imo State - Nigeria (1)
- Impella (1)
- Implicit and explicit reward learning (1)
- InSAR (1)
- InSAR height (1)
- Incontinentia pigmenti (1)
- Individualität (1)
- Induced apoptosis (1)
- Inducible Clindamycin Resistance (1)
- Induzierte pluripotente Stammzelle (1)
- Infectious disease (1)
- Inflammatio (1)
- Inflammatory Pain (1)
- Inflammatory diseases (1)
- Inflammatory pain (1)
- Information (1)
- Information Extraction (1)
- Information System (1)
- Information seeking and sharing (1)
- Information system (1)
- Informationsverarbeitung (1)
- Inhibition (1)
- Innovation (1)
- Input-Output-Tabelle (1)
- Insect flight (1)
- Insulin (1)
- Insulin-like Growth Factor I (1)
- Insulin-like growth factor-I (1)
- Integrine (1)
- Intention (1)
- Intentional Nonaction (1)
- Intentionale Nichthandlung (1)
- Interaction Design (1)
- Interactions (1)
- Interconnection (1)
- Interface Conductivity (1)
- Interfaces (1)
- Intergenerational income mobility (1)
- Intergenerationenmobilität (1)
- Intergenerative Einkommensmobilität (1)
- Interleukin-10 (1)
- Interleukin-6 (1)
- Invasion (1)
- Inverse Gaschromatographie (1)
- Invertebrate herbivory (1)
- Ionenkanal (1)
- Ionenleitfähigkeit (1)
- Ionic Liquid (1)
- Ionische Flüssigkeit (1)
- Ipilimumab (1)
- Iridate (1)
- Ischemic stroke (1)
- Isocyanate (1)
- Isolation (1)
- J-Aggregate (1)
- JAK2 (1)
- K-RAS (1)
- KIF (1)
- KIF11 (1)
- KM3NeT (1)
- KTaO3 (1)
- Kapillarelektrophorese (1)
- Kilombero (1)
- Kinect (1)
- Kinetic Self-assembly (1)
- Kleinsatellit (1)
- Klinisches Experiment (1)
- Knee (1)
- Knochenimplantat (1)
- Knochenkleber (1)
- Knochenregeneration (1)
- Knochenwachs (1)
- Knorpelbildung (1)
- Kohärente Multidimensionale Spektroskopie (1)
- Kokristallisation (1)
- Kollektive Invasion (1)
- Komplexität (1)
- Komponentenanalyse (1)
- Konditionierung (1)
- Konfidenzintervall (1)
- Konfokale Mikroskopie (1)
- Konforme Metrik (1)
- Kongo (1)
- Konische Durchschneidung (1)
- Korrelierte Fermionen (1)
- Krebs (1)
- Krebs <Medizin> (1)
- Kreditgenossenschaft (1)
- Kristallfeld (1)
- Körpergewicht (1)
- L1 reading comprehension (1)
- L2 reading comprehension (1)
- L2 reading motivation (1)
- LATE DEATHS (1)
- LC-HRESIMS (1)
- LC3-associated phagocytosis (1)
- LCD Pulse Shaper (1)
- LCD Pulsformer (1)
- LHC (1)
- LMICS (1)
- LSD1 (1)
- LST (1)
- La gestion des déchets (1)
- LaAlO3/SrTiO3 (1)
- Ladungstrennung (1)
- Ladungsträger (1)
- Ladungsträgerlokalisation (1)
- Lageregelung (1)
- Land Change Modeler (1)
- Landnutzungskartierung (1)
- Landsat time series (1)
- Lantana camara (1)
- Lanthantitanate (1)
- Laparoscopy (1)
- Large Hadron Collider (1)
- Laser Pulse Shaping (1)
- Laserpulsformung (1)
- Late mortality (1)
- Latin America (1)
- Latrophilin (1)
- Leaf traits (1)
- Learning and memory (1)
- Learning walk (1)
- Learning/physiology (1)
- Lebende Polymerisation (1)
- Lee Smolin (1)
- Leptonic (1)
- Lernen (1)
- Lernverhalten (1)
- Leseverstehen (1)
- Lewis-base adducts (1)
- Library Screening (1)
- Lichtabsorption (1)
- Lichtblattmikroskopie (1)
- Lichtheimia (1)
- Lichtscheibenmikroskopie (1)
- Lichtstreuung (1)
- Lidschlag (1)
- Lifetime spectroscopy (1)
- Ligand <Biochemie> (1)
- Light sheet microscopy (1)
- Limb development (1)
- Limb salvage (1)
- Limestone (1)
- Liquid Crystal (1)
- Liquid Crystals (1)
- Living Polymerisation (1)
- Llullaillaco Volcano (1)
- Lokalisation (1)
- Low energy electron microscopy LEEM (1)
- Low risk alcohol use (1)
- Low-income Countries (1)
- Lung (1)
- Lung disease, (1)
- Lunge (1)
- Lyapunov Stability (1)
- Lymph nodes (1)
- Lysine-specific methylase (1)
- Löslichkeit (1)
- M14 carboxypeptidasses (1)
- MASS (1)
- MCP1 (1)
- MDSC (1)
- MGMT promoter methylation (1)
- MI-RADS (1)
- MIBG (1)
- MLST (1)
- MMB (1)
- MMB complex (1)
- MODIS (1)
- MOF (1)
- MOLLI (1)
- MRI (1)
- MRI spectroscopy (1)
- MRSA (1)
- Maculinea butterfly (1)
- Magnesiumphosphate (1)
- Magnetic Resonance Imaging (1)
- Magnetic resonance imaging (1)
- Magnetische Eigenschaft (1)
- Magnetismus (1)
- Magnetit (1)
- Magnetometry (1)
- Magnetoresistance (1)
- Magnetowiderstand (1)
- Magnon (1)
- Makrokolonie (1)
- Male (1)
- Mamma carcinoma (1)
- Mammakarzinom (1)
- Management (1)
- Managementinformationssystem (1)
- Manganese Carbonyl ligands (1)
- Mangansilicide (1)
- Manöverintention (1)
- Masern-Virus (1)
- Masticatory mucosa (1)
- Mastoid process (1)
- Mathematik (1)
- Matter (1)
- Mc4r (1)
- Measles virus (1)
- Measurement error correlation (1)
- Measurement-based Analysis (1)
- Meat (1)
- Mechanisms (1)
- Mechanisms of Social Attention (1)
- Mechanismus (1)
- Mechanosensation (1)
- Media Psychology (1)
- Medical research (1)
- Medienkonsum (1)
- Megakaryopoese (1)
- Megakaryozytopoese (1)
- Melanom (1)
- Melt Electrowriting (1)
- Memory B cells (1)
- Meniskus (1)
- Meniskusimplantat (1)
- Mensch-Maschine-Kommunikation (1)
- Merger-specific Efficiency Gains (1)
- Mergers (1)
- Mergers and Acquisitions (1)
- Merocyanine dyes (1)
- Mesenchymal stem/stromal cells (1)
- Messenger-RNAs (1)
- Messung (1)
- Metadynamik (1)
- Metal clusters (1)
- Metall-Isolator-Phasenumwandlung (1)
- Metallorganisches Netzwerk (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methodology (1)
- Metrics (1)
- Metrologie (1)
- Mfn2 KO mice (1)
- Microbiology and Infectious Disease (1)
- Midollo-Osseo (1)
- Migration (1)
- Mikroskopie (1)
- Mikrotubulus (1)
- Minimal change disease (1)
- Minimally invasive surgery (1)
- Missing Energy (1)
- Mitochondria (1)
- MnSi (1)
- Mobile genetic element (1)
- Model specification (1)
- Model-based Performance Prediction (1)
- Modell (1)
- Modifikation von Biokeramiken (1)
- Modular Hamiltonian (1)
- Modularer Hamiltonoperator (1)
- Molekulardynamik (1)
- Molekularstrahlepitaxie (1)
- Molekülsystem (1)
- Monoschicht (1)
- Monte Carlo simulation (1)
- Monte-Carlo-Simulation (1)
- Moral Hazard (1)
- Motivation (1)
- Motor behaviour (1)
- Mott Transistion (1)
- Mott-Isolator (1)
- Mott-Übergang (1)
- Mouse (1)
- Movement behavior (1)
- Mucor (1)
- Mucorales (1)
- Multi-Messenger (1)
- Multiferroics (1)
- Multiferroika (1)
- Multiphotonenmikroskopie (1)
- Multiple (1)
- Multiple myeloma (1)
- Multiple-Scattering (1)
- Multiplex PCR (1)
- Multiwavelength Astronomy (1)
- Muon spectrometers (1)
- Muscle function (1)
- Muscle power (1)
- Muster (1)
- Mutation (1)
- Myb-MuvB (1)
- Myrmecology (1)
- Myrmica ant non-equilibrium dynamics (1)
- N-heterocyclic olefins (1)
- NAFLD (1)
- NASH (1)
- NCH93 (1)
- NCI-H295R (1)
- NCO-sP(EO-stat-PO) (1)
- NF-Kappa-B (1)
- NF-κB/NFAT reporter cells (1)
- NFATc1 (1)
- NFκB (1)
- NHCs (1)
- NH\(_{3}\) (1)
- NIPAL4 (1)
- NIQs (1)
- NIR OLED (1)
- NLO Computations (1)
- NMR spectroscopy (1)
- NMR-Spektroskopie (1)
- Nachhaltigkeit (1)
- Nahfeldoptik (1)
- Nahrungserwerb (1)
- Nanoparticles (1)
- Nanostruktur (1)
- Naphthylisoquinoline (1)
- Naphthylisoquinoline alkaloids (1)
- Nasal Carriage (1)
- Necrotizing enterocolitis (1)
- Nectin‐2 (1)
- Neisseria gonorrhoeae (1)
- Neolithic period (1)
- Nephroblastom (1)
- Nephrogenese (1)
- Netherlands (1)
- Netzwerk (1)
- Neural Differentiation (1)
- Neuroanatomie (1)
- Neurodevelopmental Disorder (1)
- Neuroimaging (1)
- Neuroinflammation (1)
- Neuroscience (1)
- Neutrino Detectors and Telescopes (experiments) (1)
- Neutrino Mass (1)
- Neutrinos (1)
- Nfatc1 (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nigeria (1)
- Nivolumab (1)
- Nociceptor (1)
- Non-coding RNA (1)
- Non-smooth optimal control (1)
- Nonlinear Dynamics (1)
- Non‐ischaemic cardiogenic shock (1)
- Nuclear Medicine (1)
- Nucleus subthalamicus (1)
- Numerical Cognition (1)
- Nursing homes (1)
- OSCC (1)
- OSI (1)
- Oberflächenfunktionalisierung (1)
- Oberflächenphonon (1)
- Oberflächenphysik (1)
- Oberflächenplasmon (1)
- Object recognition (1)
- Oculomotor Muscles/physiology (1)
- Oncology (1)
- Operations Management (1)
- Optical spectroscopy (1)
- Optik (1)
- Optimal foraging (1)
- Optimale Kontrolle (1)
- Optogenetics (1)
- Oral anticoagulation (1)
- Ordered metal adsorbates on semiconductor surfaces (1)
- Ordinal Categorical Indictators (1)
- Organic and hybrid semiconductors (1)
- Organische Chemie (1)
- Oscillation (1)
- Outer membrane proteins (1)
- Overstatement models (1)
- OxPL (1)
- Oxide Heterostructure (1)
- Oxidized Phospholipids (1)
- Oxidized phospholipids (1)
- P(P) over-bar collisions (1)
- P-glycoprotein (1)
- P-gp (1)
- PA-flexed view (1)
- PALS (1)
- PCR (1)
- PD-1 (1)
- PD-L1 (1)
- PDF neurons (1)
- PET/CT (1)
- PKD1 (1)
- PP collisions (1)
- PRKACA (1)
- PROMISE (1)
- PSMA (1)
- PSMA-RADS (1)
- PTEN (1)
- Parametric inference (1)
- Parkinson’s disease (1)
- Partial Least Squares Path Modeling (1)
- Particle accelerators (1)
- Particle tracking detectors (Gaseous detectors) (1)
- Particle-acceleration (1)
- Parvovirus (1)
- Paternal age and BMI effects (1)
- Pathogenesis (1)
- Pathogens (1)
- Patterns and drivers of invertebrate herbivory (1)
- Patterns and drivers of species diversity of phytophagous beetles (1)
- Patterns and drivers of species richness and community biomass of large mammals (1)
- Pavlovian-to-instrumental transfer (1)
- Pediatric Nuclear Medicine (1)
- Pediatric Patients (1)
- Peierls-Übergang (1)
- Pendeln (1)
- Pentixafor (1)
- Perception (1)
- Perowskit (1)
- Personalized medicine (1)
- Perturbative/Functional Renormalization Group (1)
- Perturbative/Funktionale Renormierungsgruppe (1)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (1)
- Perylenbisimide (1)
- Perylenbisimides (1)
- Perylene Bisimide (1)
- Perylene Bisimides (1)
- Pfadintegral (1)
- Pflanzen (1)
- Pflanzenhormone (1)
- Phagozytose (1)
- Pharmakokinetik (1)
- Pharmakotherapie (1)
- Phase- (1)
- Phenols (1)
- Phobie (1)
- Phosphatasen (1)
- Phosphoglykolat-Phosphatase (1)
- Phosphoglykolatphosphatase (1)
- Phospholipide (1)
- Phosphorylation (1)
- Photic (1)
- Photoelectron Spectroscopy (1)
- Photoelektronenspektroskopie (1)
- Photoemission electron microscopy PEEM (1)
- Photoluminescence (1)
- Photolumineszenz (1)
- Photoreceptor (1)
- Physical activity (1)
- Physiologie (1)
- Phytochemical investigations of a Congolese Ancistrocladus Liana (1)
- Phytochemie (1)
- Pigmentdispergierender Faktor (1)
- Plant signalling (1)
- Plants (1)
- Plasmaantrieb (1)
- Plasmamembranorganisation (1)
- Plasmon (1)
- Platzierungsalgorithmen (1)
- Poly(2-oxazolin)e (1)
- Polyethylenglykole (1)
- Polygonum cuspidatum (1)
- Polymer-drug interaction (1)
- Polymere (1)
- Polymers (1)
- Polynomial Factor Models (1)
- Polyphenole (1)
- Polysaccharide (1)
- Poplars (1)
- Positron annihilation spectroscopy (1)
- Positron-Emission Tomography (1)
- Postoperative complications (1)
- Preconcentration (1)
- Predictive Analytics (1)
- Prefrontal cortex (1)
- Premna (1)
- Prescriptive Analytics (1)
- Preterm birth (1)
- Prevalence (1)
- Prior information (1)
- Privatsphäre (1)
- ProQ (1)
- Probability theory (1)
- Prognostic markers (1)
- Prognostic scoring system (1)
- Prospektives Gedächtnis (1)
- Protease-sensitive release (1)
- Protein (1)
- Protein Kinase D (1)
- Protein Kinase D 1 (1)
- Protein folding (1)
- Protein kinase D3 (PKD3) (1)
- Proteinkinase A (1)
- Proteinkinase D (1)
- Proteomics Analysis of Complexes (1)
- Proteotype (1)
- Proteus vulgaris (1)
- Proton-Proton Collisions (1)
- Präsenz (1)
- Präzisionsmessung (1)
- Psychiatric disorders (1)
- Psychiatrie (1)
- Psychologie (1)
- Psychology (1)
- Psychometrie (1)
- Psychomotor Performance/physiology (1)
- Pulmonary function tests (1)
- Pulsed laser deposition (1)
- Punktwolke (1)
- Quality assessment of antimalarial medicines from the Congo (1)
- Quality ccontrol (1)
- Quality-control (1)
- Qualität der Abschlussprüfung (1)
- Qualität der Rechnungslegung (1)
- Qualitätskontrolle (1)
- Quanten-Hall-Effekt (1)
- Quanten-Monte-Carlo (1)
- Quanteninformation (1)
- Quantenpunkt (1)
- Quantifizierung (1)
- Quantitative Mikroskopie (1)
- Quantum Hall effect (1)
- Quantum electrodynamics (1)
- Quinolone amides (1)
- R package (1)
- RADS (1)
- RAS Evaluation (1)
- RCT (1)
- REDD1 (1)
- RFID (1)
- RNA Sequencing (1)
- RNA expression (1)
- RNA metabolism (1)
- RNA protein interactions (1)
- RNA secondary structures (1)
- RNA-Seq (1)
- RNA-seq transcriptome (1)
- RNAi (1)
- RNAlater (1)
- RNS (1)
- ROR1 (1)
- ROS (1)
- RSV-A ON1 (1)
- RT-qPCR (1)
- Radiation (1)
- Radiation Protection (1)
- Radiation exposure (1)
- Radiation-associated Cancer Risk (1)
- Radiographs (1)
- Radiotherapy (1)
- Raphe (1)
- RapidEye (1)
- Raumwahrnehmung (1)
- Regelbasiertes Modell (1)
- Regimes (1)
- Regional trade (1)
- Regionaler Arbeitsmarkt (1)
- Regionaler Handel (1)
- Regionalpolitik (1)
- Regionalwirtschaft (1)
- Regulierung (1)
- Reiz (1)
- Relativistic heavy-ion collisions (1)
- Reminder e-mails (1)
- Remnant RX J1713.7-3946 (1)
- Remote Sensing (1)
- Reporter Cells (1)
- Reporterzellen (1)
- Rescue behaviour (1)
- Research Article (1)
- Respiratory tract infection (1)
- Retinopathy (1)
- Rhizomucor (1)
- Rhizopus (1)
- RhoA (1)
- Rhodopsin (1)
- Ribozyme-catalyzed RNA labeling (1)
- Ringöffnungspolymerisation (1)
- Risk (1)
- Risk Assessment (1)
- Roboter (1)
- Robotics (1)
- Runge-type Theorems (1)
- Ruthenium (1)
- Ruxolitinib (1)
- Röntgenastronomie (1)
- Röntgendiffraktometrie (1)
- S. aureus (1)
- SASHA (1)
- SB332235 (1)
- SIX1 (1)
- SPOT-6 (1)
- SR/mitochondria metabolic feedback (1)
- SREBP (1)
- SSR42 (1)
- SSTR (1)
- SSTR-RADS (1)
- ST 772 (1)
- ST18 (1)
- SWAT (1)
- SWAT model (1)
- Saccades/physiology (1)
- Salmo trutta fario (1)
- Satellit (1)
- Scarabaeidae (1)
- Scattering (1)
- Scenario analysis (1)
- Scheme for solving optimal control problems (1)
- Schlichte Funktion (1)
- Schmerzforschung (1)
- Schmerztherapie (1)
- Secondary stroke prevention (1)
- Sediment (1)
- Segmentation (1)
- Sekundärprävention (1)
- Selbstassemblierung (1)
- Self-assembly (1)
- Self-navigation (1)
- Self-renewal (1)
- Semantics (1)
- Semantik (1)
- Sense of Agency (1)
- Sensor Fusion (1)
- Sentinel-2 (1)
- Septine (1)
- Sequential quadratic Hamiltonian scheme (1)
- Serine proteases (1)
- Server (1)
- Sex chromosome (1)
- Sex determination (1)
- Sexual development and function (1)
- ShMOLLI (1)
- Shelf-life (1)
- Shell (1)
- Sibling donor (MSD) (1)
- Silver (1)
- Single Molecule Localization Microscopy (SMLM) (1)
- Single-Photon (1)
- Situationsbewusstsein (1)
- Skin (1)
- Skull (1)
- Small RNA (1)
- Small interfering RNAs (1)
- Small-Gain Theorem (1)
- Smoking (1)
- Social Cognition (1)
- Social Cueing (1)
- Social Web (1)
- Societe Francaise (1)
- Soft tissues (1)
- Software (1)
- Software Defined Networking (1)
- Software Performance Engineering (1)
- Software-defined Networking (1)
- Softwarisierte Netze (1)
- Solid tumors (1)
- Somites (1)
- Soziale Aufmerksamkeit (1)
- Soziale Mobilität (1)
- Soziale Software (1)
- Spatial Cognition (1)
- Spatially resolved 2D spectroscopy (1)
- Species delimitation (1)
- Species richness (1)
- Specific Phobia (1)
- Specimen grinding (1)
- Speckle tracking (1)
- Spezifische Phobien (1)
- Spezifische Wärme (1)
- Sphingosine-1-phosphate (1)
- Sphingosine-1-phosphats (1)
- Spin flip (1)
- Spin-Bahn-Kopplung (1)
- Spin-Orbit interaction (1)
- Spin-Phonon Kopplung (1)
- Spin-chemistry (1)
- Spin-phonon coupling (1)
- Spinflüssigkeit (1)
- Stability (1)
- Stabilität (1)
- Stammzelle (1)
- Standardmodell <Elementarteilchenphysik> (1)
- Staphylococcus aureus USA300 (1)
- Starke Kopplung (1)
- Stechameisen (1)
- Stem cell (1)
- Stem-cell biotechnology (1)
- Stenosis degree (1)
- Stenosis length (1)
- Stereochemistry (1)
- Sternpolymere (1)
- Stigmatisierung (1)
- Stimme (1)
- Stimmverarbeitung (1)
- Stimulation (1)
- Stoffwechsel (1)
- Stokes-shifted fluorescence emission (1)
- Strains (1)
- Strange Baryon Production (1)
- Strategisches Management (1)
- Stratigraphy (1)
- Streptococcus agalactiae (1)
- Stroke (1)
- Stroke unit (1)
- Stromal cells (1)
- Strontiumtitanat (1)
- Strontiumvanadate (1)
- Structural Equation Modeling (1)
- Structural elucidation (1)
- Structural equation modelling (1)
- Structure elucidation (1)
- Struktur-Aktivitäts-Beziehung (1)
- Strukturgleichungsmodell (1)
- Sub-Saharan Africa (1)
- Subject (1)
- Subtercola vilae (1)
- Success Factors (1)
- Supernova (1)
- Support vector machine (1)
- Supportive therapy (1)
- Supramolecular Block Copolymers (1)
- Supramolecular aggregates (1)
- Supramolekulare Aggregate (1)
- Supramolekulare Struktur (1)
- Surface Plasmon (1)
- Surface Raman spectroscopy (1)
- Surgical and invasive medical procedures (1)
- Surgical oncology (1)
- Survey (1)
- Suspensionskultur (1)
- Swine (1)
- Syap1 knockout (1)
- Symmetry (1)
- Systemic sclerosis (1)
- T cell (1)
- T cell receptor (1)
- T cell suppression (1)
- T cells (1)
- T-cell lymphoma (1)
- T1 mapping (1)
- TDDFT (1)
- TDMT (1)
- TEV (1)
- TFP (1)
- TGFβ/BMP signaling (1)
- TLR2 (1)
- TLR3 (1)
- TLR4 (1)
- TMEM16F (1)
- TNF (1)
- TNF-alpha (1)
- TNFR family costimulatory receptors (1)
- TNFR2 (1)
- TNFR2 agonists (1)
- TNFR2 antagonism (1)
- TNFα (1)
- TNNI3 (1)
- TP53 (1)
- TPCA1 (1)
- TRAF1 (1)
- TRAF2 (1)
- TRAILR1 (1)
- TRAILR2 (1)
- TRPA1 channel (1)
- TWEAK (1)
- Tagesrhythmus (1)
- Tamoxifen (1)
- TanDEM-X (1)
- Tc-99m-MAG3 Scans (1)
- TeV energies (1)
- Telemedizin (1)
- Temozolomide (1)
- Terramechanics (1)
- Theoretische Chemie (1)
- Therapeutisches System (1)
- Therapie (1)
- Therapiesimulation (1)
- Thermodynamik (1)
- Thin Films (1)
- Thin intermetallic films (1)
- Thiotepa-busulfan-fludarabine (TBF) (1)
- Thrombo-inflammation (1)
- Thrombosis (1)
- Thrombozytopenie (1)
- Thrust Vector Control (1)
- Tiermodell (1)
- Time resolved measurements (1)
- Time-resolved photoemission electron microscopy (1)
- Time-resolved photoluminescence (1)
- Tissue engineering (1)
- Toddler (1)
- Top quark (1)
- Topological insulators (1)
- Topologische Isolatoren (1)
- Topologischer Isolator (1)
- Torque (1)
- Total Factor Productivity (1)
- Tourenplanung (1)
- Tractography (1)
- Transcription (1)
- Transcription factor NRF1 (1)
- Transcriptomic (1)
- Translation (1)
- Translation Initiation (1)
- Translational research (1)
- Transplantat-Wirt-Reaktion (1)
- Transposable element (1)
- Transverse-Momentum (1)
- Trees (1)
- Tregs (regulatory T cells) (1)
- Triquinacenderivate (1)
- Triticeae (1)
- Triticum aestivum (1)
- Trousseau's syndrome (1)
- Trypanosomiase (1)
- Tryptophan hydroxylase (1)
- Tubulin (1)
- Tumor (1)
- Tumorzelle (1)
- Twin Domains (1)
- Twin Suppression (1)
- Two-color pump-probe spectroscopy (1)
- U-Net (1)
- USA (1)
- UV-VIS-Spektroskopie (1)
- UV/Vis spectroscopy (1)
- UV–Vis (1)
- Ultrakurzzeitspektroskopie (1)
- Ultrarelativistic Heavy-Ion (1)
- Ultrashort echo time - UTE (1)
- Umwelt (1)
- Unconventional/Topological superconductivity (1)
- Universal Functions (1)
- Unkonventionelle/Topologische Supraleitung (1)
- Unnötige Warnung (1)
- Unrelated donor (UD) (1)
- Unternehmensverfassung (1)
- User Behavior (1)
- User-Guidelines (1)
- Ustilago maydis (1)
- V-ATPase (1)
- VLBW (1)
- VMAT (1)
- Vakuole (1)
- Valentine Leukocidin Genes (1)
- Valgus osteoarthritis (1)
- Value at Risk (1)
- Vascularized (1)
- Vaskularisation (1)
- Vcsels (1)
- Verarbeitende Industrie (1)
- Verbundwerkstoff (1)
- Verkehrspsychologie (1)
- View (1)
- Virtuelle Realität (1)
- Visuelle Aufmerksamkeit (1)
- Visuo-tactile congruency (1)
- Voice Processing (1)
- W & Z bosons (1)
- W-Boson (1)
- WSS (1)
- Wahrscheinlichkeitstheorie (1)
- Warnung (1)
- Waste management (1)
- Weak-Interactions (1)
- WebGIS (1)
- Wechselwirkungen (1)
- Wheel (1)
- White matter lesions (1)
- Wide-gap-Halbleiter (1)
- Wilms tumor (1)
- Wilms-Tumor (1)
- Winkelaufgelöste Photoemission mit harten Röntgenstrahlen (1)
- Wire chambers (MWPC, Thin-gap chambers, drift chambers, drift tubes, proportional chambers etc) (1)
- Wirkstoff (1)
- Wirkstofftestung (1)
- Wirtschaftliche Integration (1)
- Wirtschaftsinformatik (1)
- Woodhouse-Sakati Syndrom (1)
- Woodhouse-Sakati sydrome (1)
- Wundheilung (1)
- X-ray radiography (1)
- XRD (1)
- YAP (1)
- Yoga (1)
- Young Adult (1)
- ZF1 degradation assay (1)
- ZFAND1 (1)
- Zahnbehandlungsphobie (1)
- Zebrafish (1)
- Zell Migration (1)
- Zelloberfläche (1)
- Zentralasien (1)
- Zinc (1)
- Zinkselenid (1)
- ZnO-NP (1)
- Zusammenstoß (1)
- Zwillingsbildung (1)
- [68Ga]Pentixafor (1)
- \(^{177}\)Lu-OPS201 (1)
- abdominal surgery (1)
- absolute bioavailability (1)
- accessory medulla (1)
- accidents (1)
- accumulation (1)
- accuracy (1)
- acetate (1)
- acid ceramidase (1)
- acid ceramidase inhibitor ceranib-2 (1)
- acoustic radiation force impulse imaging (1)
- acrophobia (1)
- actin (1)
- actin cytoskeleton (1)
- actin-binding proteins (1)
- action control (1)
- activated delayes flourescence (1)
- activation (1)
- active galactic nuclei (1)
- active ingredients (1)
- acute kidney injury (1)
- acute lymphoblastic leukemia (1)
- adalimumab (1)
- additive manufacturing (1)
- adenoma (1)
- adenotonsillectromy (1)
- adipocyte (1)
- adipose (1)
- adiposity (1)
- administrative boundary (1)
- adrenocortical carcinoma (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- advanced breast cancer (1)
- aerobic fitness (1)
- affect bursts (1)
- age at onset (1)
- age groups (1)
- age-related macular degeneration (1)
- agriculture (1)
- airway management (1)
- alkaloids-Quinoid (1)
- alkynes (1)
- alternative splicing (1)
- altitudinal gradients (1)
- alveolar epithelium (1)
- amine borane dehydrocoupling (1)
- aminergic neurons (1)
- amodiaquine (1)
- amorphous solid dispersion (1)
- amphiphilic block copolymer (1)
- amsacrine (1)
- amyloidoma (1)
- amyotrophic lateral sclerosis (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anakinra (1)
- analysis of variance (1)
- animal research (1)
- anime (1)
- anomaly detection (1)
- anorexia nervosa (1)
- anti-contactin-1 (1)
- anti-depressant drug (1)
- antibacterial (1)
- antibacterial activity (1)
- antibiofilm (1)
- antibiotic resistance (1)
- anticancer (1)
- anticipation (1)
- antifungal (1)
- antitrypanosomal (1)
- anti‐aging (1)
- anxiety generalization (1)
- anxiolytics (1)
- aortocaval fistula model (1)
- appraisal theory of emotion expression (1)
- arctic greening (1)
- arenes (1)
- artemether - lumefantrine (1)
- artifacts (1)
- artificial intelligence (1)
- artificial light at night (1)
- aspergillosis (1)
- asylum seekers (1)
- asylum status (1)
- atmospheric waves (1)
- atrial fibrillation (1)
- auto-planning (1)
- autoantibody (1)
- autobiography (1)
- autoimmune disease (1)
- autosomal recessive (1)
- auxin (1)
- axillary dissection (1)
- back reaction (1)
- bacterial pathogen (1)
- bacterial physiology (1)
- bacteriology (1)
- baghdadite (1)
- balancing trade-offs (1)
- bank mergers (1)
- bariatric surgery (1)
- behavior (1)
- behavioral plasticity (1)
- beige adipocytes (1)
- bench press (1)
- bending strength (1)
- benige tumor (1)
- beta-lactam antibiotics (1)
- biceps tendinitis (1)
- biceps tendon (1)
- big earth data (1)
- bilateral internal carotid artery stenosis (1)
- binary species (1)
- bioavailability (1)
- bioceramics (1)
- biofabricated vascular graft (1)
- biofilm architecture (1)
- bioinformatics tool (1)
- bioink (1)
- bioinks (1)
- biokinetics (1)
- biological rhythm (1)
- biological scaffolds (1)
- biological techniques (1)
- biomarker (1)
- biomarker signature (1)
- biomaterial ink (1)
- biomaterials (1)
- biomechanics (1)
- biomolecular processes (1)
- bioreactor (1)
- biotic interaction (1)
- bispecific antobodies (1)
- bisulfite pyrosequencing (1)
- black trout syndrome (1)
- bladder (1)
- blazars (1)
- blinatumoman (1)
- blinking (1)
- blocking phagocytosis (1)
- blood (1)
- blood brain barrier (1)
- blood cerebrospinal fluid barrier (1)
- blood-cerebrospinal fluid barrier (1)
- bohrbar (1)
- bone critical size defect (1)
- bone graft substitutes (1)
- bone marrow stromal cells (1)
- bone wax (1)
- boolean modeling (1)
- boreholes (1)
- borohydrides (1)
- boronate (1)
- boronic acid (1)
- borylenes (1)
- bottom-up processing (1)
- brain (1)
- brain activity (1)
- brain development (1)
- brain disorders (1)
- brain endothelial cell (1)
- brain endothelial cells (1)
- brain networks (1)
- brain plasticity (1)
- brain tumor (1)
- breast cancer (1)
- bridge-to-transplant (1)
- bronchoalveolar lavage fluid (1)
- bronchopulmonary dysplasia (1)
- brown trout (1)
- building (1)
- bullae (1)
- burn severity (1)
- burnt-wood (1)
- calcium (1)
- calcium phosphate (1)
- calnexin (1)
- calving front (1)
- cancer immunotherapy (1)
- cancer metabolism (1)
- capillary zone electrophoresis (1)
- carabid beetles (1)
- carbenes (1)
- carbon (1)
- carbon monoxide (1)
- cardiac metabolism (1)
- cardiac remodelling (1)
- cardiac surgery (1)
- cardiac tissue (1)
- cardiolipin (1)
- cardiomyocytes (1)
- cardiopulmonary bypass (1)
- cardiovascular genetics (1)
- cardiovascular risk factors (1)
- care (1)
- cartilage repair (1)
- catalysis (1)
- catchment (1)
- catheterization (1)
- catheters (1)
- caveolin-1 (Cav-1) (1)
- cefotiam (1)
- cell biology (1)
- cell differentiation (1)
- cell migration (1)
- cell signalling (1)
- cell therapy and immunotherapy (1)
- cellular model (1)
- ceramide (1)
- cerebral microbleeds (1)
- cerebrospinal fluid (1)
- cervical dystonia (1)
- channelrhodopsins (1)
- charge carrier localization (1)
- charge recombination (1)
- charge separation (1)
- chemical crosslinking (1)
- chemokine (1)
- chemokine receptor (1)
- child behavior (1)
- chimeric antigen receptor (1)
- chirality (1)
- chirality-induced spin selectivity (1)
- chlamydia (1)
- chlorophyll fluorescence imaging (1)
- cholesterol (1)
- cholesterol 25 hydroxylase (1)
- cholesteryl ester (1)
- chondrocyte (1)
- chondrogenesis (1)
- chronic kidney disease (1)
- chronic kidney disease (CKD) (1)
- chronic non-bacterial osteomyelitis (1)
- circRNA (1)
- circadian clock (1)
- circadian rhythm (1)
- circadian rhythms (1)
- circular transcriptome sequencing (1)
- cisplatin (1)
- claudin-5 (1)
- click chemistry (1)
- climate extremes (1)
- clinical characteristics (1)
- clinical imaging (1)
- clinical outcome (1)
- clinical pharmacy (1)
- clinical trial (1)
- closed-loop systems (1)
- cluster analysis (1)
- co-culture (1)
- coagulation system (1)
- coastline (1)
- cocrystal (1)
- cognitive control (1)
- coherence (1)
- coherent risk measures (1)
- cold adaptation (1)
- collagen sponge (1)
- collective invasion (1)
- collimator (1)
- collodion baby (1)
- collybistin (1)
- colonization (1)
- commission error (1)
- common diseases (1)
- comparative genomics (1)
- comparison (1)
- competition (1)
- complement deposition (1)
- complement factor H (1)
- complex DNA damage (1)
- composite material (1)
- composition (1)
- computer-mediated communication (1)
- concealed information test (1)
- conditioning (1)
- congruency sequences (1)
- conjugation (1)
- consensus (1)
- conservation (1)
- constructed trade-offs (1)
- context-based teaching (1)
- contextual fear conditioning (1)
- continuous theta burst stimulation (cTBS) (1)
- continuum limit (1)
- control levels (1)
- convolutional neural network (1)
- copeptin (1)
- coping (1)
- copy number variation (1)
- coronary heart disease (1)
- correspondence (1)
- cortical excitability (1)
- cortical silent period (1)
- cosmology (1)
- count time series (1)
- covalent and site-specific RNA labeling (1)
- cristal engeneering (1)
- crop statistics (1)
- cross-coupling (1)
- cross-sectional study (1)
- cryosphere (1)
- cryostructured scaffolds (1)
- crystal growth (1)
- crystallization (1)
- crystallography (1)
- curcumin (1)
- curvature (1)
- curved hydrocarbons (1)
- cuticular permeability (1)
- cyclase-associated protein (1)
- cyclase-associated protein 2 (1)
- cyclic compounds (1)
- cyclophosphamide (FLAMSA) (1)
- cytokinesis (1)
- cytoskeleton (1)
- cytotoxic (1)
- daratumumab (1)
- data structure (1)
- data warehouse (1)
- dead-wood enrichment (1)
- decay (1)
- decellularization (1)
- deception (1)
- deep learning (1)
- default-interventionist framework (1)
- definition (1)
- dehydrocoupling (1)
- dehydrogenaticve borylation (1)
- democracy (1)
- democracy profiles (1)
- dendritic cell (1)
- depth dose curves (1)
- designer cell (1)
- desk-based (1)
- desmin (1)
- desmin-related myopathy (1)
- desminopathy (1)
- desmoglein (1)
- desmoplastic small round cell tumor (1)
- desmosome (1)
- deubiquitinases (1)
- developmental forms (1)
- dexamethasone (1)
- diabetes (1)
- diacylglycerol (1)
- diacylglycerol (DAG) (1)
- diagnostic markers (1)
- dialysis adequacy (1)
- diazadiborinines (1)
- diborane(6) (1)
- diboranes (1)
- diboration (1)
- diborene (1)
- diborenes (1)
- diborynes (1)
- differentiation (1)
- differentiation potential (1)
- diffuse large B-cell lymphoma (1)
- diffusion weighted mri (1)
- digital health (1)
- diluted magnetic Semiconductor (1)
- dimeric peptide (1)
- direct muss spectrometric profiling (1)
- discrete systems (1)
- disease genetics (1)
- disease modelling (1)
- dissolution rates (1)
- distractor-response binding (1)
- distributed control (1)
- distributed learning (1)
- distributions (1)
- diversity gradients (1)
- document analysis (1)
- domain-specific language (1)
- donor (1)
- donor-acceptor systems (1)
- dorsal root ganglion (1)
- dose individualization (1)
- dosimetry (1)
- double arc (1)
- doxorubicin (1)
- drillable (1)
- drivers and patterns of diversity and herbivory (1)
- driving simulation (1)
- drought (1)
- drug release (1)
- drug resistance evolution (1)
- dual abbindend (1)
- dual setting (1)
- dual setting system (1)
- dualsteric (1)
- duchenne muscular dystrophy (1)
- duplication-deficiency (1)
- dyads (1)
- dyes (1)
- dynamic facial emotion expression (1)
- dystonia (1)
- e(+)e(-) Collisions (1)
- e-learning (1)
- early brain injury (1)
- early-life stress (1)
- earlywood (1)
- eccentric hypertrophy (1)
- echocardiography (1)
- ecosystem service (1)
- education system (1)
- effective point of measurement (1)
- efficient intervention points (1)
- eindimensionale Systeme (1)
- electrical resistivity tomography (1)
- electrochemistry (1)
- electron-precise diborates (1)
- electrospun fibers (1)
- elementary body (1)
- eletrhydrodynamic (1)
- emission (1)
- emotion (1)
- emotion enactment (1)
- emotion processing (1)
- emotion recognition (1)
- emotional behavior (1)
- emotions (1)
- emulsions oil-in-water (1)
- en bloc transfer (1)
- enantiomers (1)
- enbrel (1)
- end-stage renal disease (1)
- endocytosis (1)
- endothelial cells (1)
- endothelin-1 (1)
- endurance (1)
- enercy-richness hypothesis (1)
- energy homeostasis (1)
- enhancer (1)
- environmental justice (1)
- environmental sustainability (1)
- enzyme mechanism (1)
- epidural block (1)
- epithelial-mesenchymal transition (1)
- error estimation (1)
- estimation error (1)
- etanercept (1)
- ethics (1)
- eugenol (1)
- evapotranspiration (1)
- exciton (1)
- exciton dynamics (1)
- exciton-polariton (1)
- exercise intervention (1)
- expansion microscopy (1)
- expected value of control (1)
- external stimuli (1)
- extinction (1)
- extinction dynamics (1)
- extracellular domain (1)
- extramedullary hematopoiesis (1)
- extreme phenotypes (1)
- eye movement (1)
- eye movements (1)
- eye-tracking (1)
- fMRI (1)
- fMRT (1)
- face (1)
- face-voice integration (1)
- faces (1)
- fan culture (1)
- fatigue (1)
- fault detection (1)
- fear (1)
- fear learning (1)
- febrile seizures (1)
- feminist rap (1)
- femoral head (1)
- fertility (1)
- fibre length (1)
- fibromyalgia (1)
- fibrotest (1)
- field-induced surface hopping (1)
- fission (1)
- flash freezing (1)
- fliegende Toilette (1)
- flora (1)
- flourescence quantum yield (1)
- flu-like symptoms (1)
- fluerescence (1)
- fluorenscence (1)
- fluorescence microscopy (1)
- fluorescent probes (1)
- fluorine (1)
- fluoroarene (1)
- fluorogen-activating RNA aptamer (FLAP) (1)
- fluoroquinolone (1)
- fluxosome (1)
- fly-tipping (1)
- flying toilet (1)
- folda-dimer (1)
- food colorings (1)
- food resources (1)
- foraging patterns (1)
- forensic sample (1)
- forest ecology (1)
- forest fire (1)
- forest management (1)
- forest resources inventory (1)
- formation control (1)
- fractional variability (1)
- fracture (1)
- fragmentation functions (1)
- free choice (1)
- free movement (1)
- free radical polymerization (1)
- friut fly behaviour (1)
- full arc (1)
- fully convolutional neural networks (1)
- function (1)
- functional MRI (1)
- functional analysis (1)
- functional connectivity (1)
- functional training (1)
- fungal molecular diagnostics (1)
- fungal rhodopsins (1)
- funktionale Präpolymere (1)
- games (1)
- gangliosides and lipid rafts (1)
- gastric-bypass surgery (1)
- gastrointestinal cancer (1)
- gastrointestinal tract (1)
- gauge/gravity duality (1)
- gaze control (1)
- gekrümmte Kohlenwasserstoffe (1)
- gem-bisboronates (1)
- gene alleles (1)
- gene expression analysis (1)
- gene family evolution (1)
- gene network (1)
- gene regulation (1)
- genetic codon expansion (1)
- genetic counselling (1)
- genetic engineering (1)
- genetic recombination (1)
- genome (1)
- genome analysis (1)
- genome-wide association studies (1)
- genomic imprinting (1)
- genotoxicity (1)
- glacier front (1)
- glacier terminus (1)
- glia cells (1)
- glioblastoma multiforme (GBM) (1)
- glioma (1)
- global (1)
- global change (1)
- glucose transporter (1)
- glycine transporter 2 (1)
- glycoprotein Ibα (1)
- glycoprotein VI (1)
- glyvine uptake (1)
- graft vs. host disease (1)
- graft-versus host (1)
- graft-versus-host-disease (1)
- granules (1)
- gravitational waves (1)
- green fluorescence protein (GFP) (1)
- ground penetrating radar (1)
- ground-dwelling predators (1)
- growth (1)
- growth patterns (1)
- growth ring width (1)
- guanylyl cyclase (GC) (1)
- guided bone regeneration (1)
- guideline adherent treatment (1)
- guidelines (1)
- gut–liver axis (1)
- hA<sub>3</sub>AR (1)
- habit (1)
- habit strength (1)
- hadronic Recoil (1)
- hadronischer Rückstoß (1)
- haematopoietic stem cell (1)
- halogens (1)
- hard x-ray photoemission (1)
- head and neck squamous cell carcinoma (1)
- heart-to-mediastinum ratio (1)
- heat wave (1)
- helical molecules (1)
- helicenes (1)
- hematopoietic stem cell transplantation (1)
- heme oxygenase-1 (1)
- hemicraniectomy (1)
- hemodiafiltration (1)
- hemodialysis (1)
- hemophagocytosis (1)
- hemorrhagic (1)
- hemostasis (1)
- henoch-schönlein purpura (1)
- hepatitis B virus (1)
- hereditary breast and ovarian cancer (1)
- heterocycles (1)
- heterotypic scaffold design (1)
- heuristics (1)
- hiPSC aggregation (1)
- high LET irradiation (1)
- high efficiency (1)
- high risk (1)
- high-resolution tandem mass spectrometry (1)
- hip fracture (1)
- hippocampus (1)
- histological subtype (1)
- histone H2AX (1)
- historical document analysis (1)
- historical printings (1)
- homogeneous catalysis (1)
- homogenization (1)
- honeybee (1)
- honeybees (1)
- hospital exemption (1)
- hospital-acquired methicillin-resistant Staphylococcus aureus (1)
- human adipose-derived stromal cells (1)
- human behaviour (1)
- human cerebral endothelial cells (1)
- human plasma (1)
- human xenografted mouse models (1)
- hybrid fabrication (1)
- hybrid materials (1)
- hydrogels (1)
- hydrological regime (1)
- hydroxyapatite (1)
- hydroxylation (1)
- hyperosmolality (1)
- hyperpersonal communication (1)
- hypertension (1)
- hypothermia (1)
- iGC (1)
- iPSC (1)
- ichthyosis (1)
- identification (1)
- iliac crest (1)
- illness-death model (1)
- image processing (1)
- imaging (1)
- imaging PAM (1)
- immediate-early gene (1)
- immune evasion (1)
- immunity (1)
- immunocompetent skin (1)
- immunotherapy of cancer (1)
- implant (1)
- impurity profiling (1)
- in situ microscopy (1)
- in vitro model (1)
- in vitro models (1)
- in vitro selection from a structured RNA library (1)
- incidence (1)
- individualization (1)
- indole-3-acetic acid (1)
- indolylpyrimidylpiperazines (1)
- induced pluripotent stem cells (1)
- infection biology (1)
- infections (1)
- infectious diseases (1)
- inflammatory gene (1)
- inflation (1)
- information retrieval (1)
- information sharing (1)
- inherited cardiomyopathies (1)
- inherited macrothrombocytopenia (1)
- inhibition (1)
- inhibitor (1)
- injection site reactions (1)
- injury (1)
- inmates (1)
- innate immune evasions (1)
- insect abundance (1)
- insect collection (1)
- insurance medicine (1)
- intact bone imaging (1)
- integrative management strategy (1)
- integrin α2 (1)
- integrins (1)
- interactions (1)
- intercomparison (1)
- interface (1)
- interface conductivity (1)
- interferon beta (1)
- interleukin (1)
- interleukin-6 (1)
- intermediate dose Ara-C (1)
- intermediate filaments (1)
- intermittent exercise (1)
- intermolecular applications of ribozymes (1)
- internal carotid artery stenosis (1)
- intersession experiences (1)
- intersession processes (1)
- interval training (1)
- intervention point analyzing (1)
- intestine (1)
- intracellular bacterial pathogens (1)
- intracranial bleeding (1)
- invasive aspergillosis (1)
- inventory (1)
- iodine (1)
- ionization chambers (1)
- ionization energy (1)
- ionization potential (1)
- iron metabolism (1)
- ischemia reperfusion injury (1)
- ischemia time (1)
- isotropic hyper fine coupling (1)
- jet shapes (1)
- jet stream (1)
- jets (1)
- keratinocytes (1)
- key structure - fluorescence activation relationships (SFARs) (1)
- kidney (1)
- kidney development (1)
- kinesin (1)
- kinesthesia (1)
- kolorektales Karzinom (1)
- koronare Herzerkrankung (1)
- la durabilité environnementale (1)
- labour market (1)
- lag effect (1)
- land sharing (1)
- land surface (1)
- land use (1)
- land-cover area (1)
- language in media (1)
- late onset sepsis (1)
- late positive potential (1)
- lateral process of the talus (1)
- latewood (1)
- lattice forces (1)
- leaf width (1)
- learner characteristics (1)
- learning (1)
- les toilettes volantes (1)
- library screening (1)
- lichen planus (1)
- lifestyle (1)
- ligand binding (1)
- ligand exchange (1)
- ligand-receptor promiscuity (1)
- light-emitting-diodes (1)
- light-matter interaction (1)
- lightsheet microscopy (1)
- lignan (1)
- lineage-specific genes (1)
- linear conversion (1)
- linguistic cues (1)
- linguistic politics (1)
- lipid metabolism (1)
- liponeurocytoma (1)
- liquid biopsy (1)
- liver (1)
- liver metastases (1)
- local field potentials (1)
- localization microscopy (1)
- logical trade-offs (1)
- long head of biceps tendon (1)
- long-term potentiation (1)
- loss of function (1)
- low-cost photometer (1)
- low-valent compounds (1)
- low-valent main group chemistry (1)
- low-valent main-group species (1)
- lowland beech forests (1)
- luminescence (1)
- lung cancer (1)
- lung metastases (1)
- lying (1)
- lymph nodes (1)
- lymphohistiocytosis (1)
- lyso-phospholipids (1)
- mAb engineering (1)
- mRNA (1)
- mTOR (1)
- macrocolony (1)
- macrophage polarization (1)
- magnesium phosphate cement (1)
- magnetic field effect (1)
- maintenance therapy (1)
- major river basins (1)
- management (1)
- manga (1)
- manoeuvre intention (1)
- match load (1)
- maternal separation (1)
- mating (1)
- mating preference (1)
- mebendazole (1)
- mechanical performance (1)
- mechanisms of disease (1)
- mechanistic modelling (1)
- medaka (1)
- medical rehabilitation (1)
- medication extraction (1)
- medicinal plant (1)
- medicine (1)
- medieval manuscripts (1)
- medulloblastoma (1)
- megakaryocyte (1)
- melatonin (1)
- melt electrowriting (MEW) (1)
- memory (1)
- meningioma (1)
- meningococcal disease (1)
- meningococcus (1)
- meniscus implant (1)
- merocyanines (1)
- mesenchymal stem cell (1)
- mesenchymal stem cells (1)
- mesenchymal stromal cell (1)
- mesentery (1)
- meta-analysis (1)
- metabolic flux (1)
- metabolic modeling (1)
- metabolic modelling (1)
- metabolic switch (1)
- metabolism (1)
- metabolism of infected and uninfected host cells (1)
- metabolite profiling (1)
- metabolomic (1)
- metabolomic profiling (1)
- metacognition (1)
- metal complexenes (1)
- metallo-supramolecular polymer (1)
- metals (1)
- metaproteomics (1)
- metastasis (1)
- metastasis-associated in colon cancer 1 (MACC1) (1)
- methods (1)
- methylation array (1)
- methylprednisolone (1)
- miR-221-5p (1)
- micelles (1)
- micro processor complex (1)
- micro-chambers (1)
- microRNA (1)
- microbial rhodopsins (1)
- microbial surface component recognising adhesive matrix molecules (1)
- microbiota (1)
- microfilament (1)
- microtubules (1)
- midbody remnant (1)
- migrant (1)
- minerals (1)
- minimal residual disease (1)
- minipig (1)
- minocycline (1)
- mitochondrial genome (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- mitosis (1)
- mitotic gene expression (1)
- mitotic genes (1)
- mixed methods (1)
- mobile app (1)
- mobile health intervention (1)
- model-based diagnosis (1)
- molecular biology (1)
- molecular imaging (1)
- molecular neuroscience (1)
- molecular signature (1)
- molecular structures (1)
- molecular subtypes (1)
- monitoring (1)
- monocyte-derived DC (1)
- monotoring (1)
- moonlighting (1)
- morphing (1)
- motility (1)
- motor-evoked potentials (MEP) (1)
- mouse feeding model (1)
- movement (1)
- mucormycosis (1)
- multi-photon microscopy (1)
- multi-spectral (1)
- multiphoton microscopy (1)
- multiresistance (1)
- murine (1)
- muscarinic receptors (1)
- mutants (1)
- mycophenolic acid (1)
- myelination (1)
- myeloid-derived suppressor cell (MDSC) (1)
- n-Halbleiter (1)
- n-type semiconductors (1)
- nano-satellite (1)
- nanocomplex (1)
- nanoparticles (1)
- naphthylisoquinoline alkaloids (1)
- nasal mucosal barrier function (1)
- native populations (1)
- natural pest control (1)
- naturalistic scenes (1)
- naïve B cells (1)
- near-IR chromophores (1)
- necroptosis (1)
- need for assistance (1)
- negation detection (1)
- neonatal outcome (1)
- neonates (1)
- nerve injury (1)
- nervous system (1)
- nest microbiota (1)
- neume notation (1)
- neurocytoma (1)
- neurodegenerative disease (1)
- neuroendocrine neoplasia (1)
- neuroendocrine tumors (1)
- neuromuscular disease (1)
- neuronal (1)
- neuronal apoptosis (1)
- neurooncology (1)
- neuropathic pain (1)
- neurovascular unit (1)
- neutral sphingomyelinase-2 (1)
- neutrinos (1)
- next-generation sequencing (1)
- next-generation-sequencing (1)
- niche (1)
- nicknames (1)
- non-invasive fibrosis assessment (1)
- non-smooth optimization (1)
- nonalcoholic fatty liver disease (1)
- noncoding RNA (1)
- nonconvex optimization (1)
- noncovalent complex (1)
- noncovalent nanocomplex (1)
- normal distribution (1)
- nu SVR (1)
- nuclear envelope (1)
- nuclear export (1)
- null-aggregate (1)
- number of (1)
- obesity (1)
- object segmentation (1)
- obstructive sleep apnoea (1)
- office environment (1)
- office-workers (1)
- oligodendrocyte (1)
- oncogenes (1)
- oncology (1)
- oncolysis (1)
- oncolytic vaccinia virus (1)
- one-dimensional systems (1)
- online dating (1)
- online survey (1)
- ontology (1)
- open waste burning (1)
- optical antenna (1)
- optical character recognition (1)
- optical music recognition (1)
- optimal drug targeting (1)
- optimal pharmacological modulation (1)
- optimal treatment strategies (1)
- optimization (1)
- organic solar cells (1)
- orthoreovirus (1)
- oscillations (1)
- osteochondral defect (1)
- otakuism (1)
- outcome devaluation (1)
- ovarian cancer (1)
- overuse injury (1)
- oxidative DNA damage (1)
- oxidative stress (1)
- oxide heterostructure (1)
- oxidische Heterostruktur (1)
- oxindole alkaloids (1)
- oxygen vacancies (1)
- p-block element (1)
- p21-activated kinase Mbt/PAK4 (1)
- paediatrics (1)
- pain generator (1)
- panel sequencing (1)
- panic disorder (1)
- panniculitis (1)
- paranodopathy (1)
- parasexual recombination (1)
- parent-child relationship (1)
- parental perception (1)
- partial agonists (1)
- partial arc (1)
- passive transfer (1)
- patch-clamp (1)
- pathogenesis (1)
- pathogenic bacteria (1)
- peatland (1)
- pediatrics (1)
- peer review (1)
- pefloxacin (1)
- peginterferon bet-1a (1)
- pemphigus (1)
- penetration bias (1)
- penumbra (1)
- peptide inhibitor design (1)
- peptidomoics (1)
- performativity (1)
- pericytes (1)
- permeability (1)
- persistence (1)
- person identity processing (1)
- personality development (1)
- personality judgments (1)
- perylene bisimide (1)
- perylene bisimide dimers (1)
- perylene bisimides (1)
- pesicicles (1)
- pharmacokinetics (1)
- pharmacophore map (1)
- phenolic compounds (1)
- phosphorescence (1)
- phosphorescene spectra (1)
- phosphorylation (1)
- photoconductive interlayer (1)
- photodynamic chemotherapy (1)
- photoelectron spectroscopy (1)
- photoluminescence spectroscopy (1)
- photolysis (1)
- photophysical prosperties (1)
- photophysics (1)
- physical activity (1)
- physical activity promotion (1)
- physical saliency (1)
- phytic acid (1)
- pi-conjugation (1)
- piRNA (1)
- piscine orthoreovirus (1)
- pit membrane diameter (1)
- pkd (1)
- placebo and nocebo effects (1)
- plan comparison (1)
- plant reproduction (1)
- plant-derived metabolites (1)
- plants (1)
- plant–microbe–pollinator triangle (1)
- plant–pathogen interaction (1)
- plaque cross-sectional area (1)
- plasma membrane (1)
- plasma membrane depolarization (1)
- plasma membrane organization (1)
- plasminogen (1)
- platelet (1)
- platelet degranulation (1)
- podosome formation (1)
- point shear wave elastography (1)
- pointing task (1)
- pol(2-oxazoline) (1)
- polarimetery (1)
- polarization (1)
- pollination (1)
- pollination network (1)
- poly(2-oxazine) (1)
- poly(2-oxazoline) (1)
- poly(2-oxazoline)s (1)
- poly(glycidol) (1)
- polycaprolactone (1)
- polyglycerol sulfates (1)
- polynomials (1)
- polyphenols (1)
- population genetics (1)
- position estimation (1)
- positron (1)
- positron annihilation lifetime spectroscopy (1)
- post-fire management (1)
- post-translational modification (1)
- posttranscriptional control (1)
- powerlifting (1)
- pre-B (1)
- precision medicine (1)
- predictive markers (1)
- predictive performance (1)
- premature aging (1)
- premixed (1)
- presynaptic hyperekplexia (1)
- preterm infants (1)
- primary endpoint (1)
- primary healthcare (1)
- primary outcome (1)
- primary vascular smooth muscle‐like cells (vSMCs) (1)
- pro-B (1)
- probe-based real-time PCR (1)
- production machines (1)
- prognosis (1)
- prognostic marker (1)
- proliferation (1)
- proliferative darkening syndrome (1)
- prospective memory (1)
- prostate-specific membrane antigen (1)
- protected forests (1)
- protein binding (1)
- protein kinase D1 (1)
- protein processing (1)
- protein transport (1)
- protein-bound uremic toxins (1)
- protein-protein interaction (PPI) (1)
- proteomics (1)
- präfabriziert (1)
- psychological pain modulation (1)
- psychometrics (1)
- psychosocial adaptation (1)
- psychosocial stress (1)
- psychotherapy (1)
- puberty (1)
- pyrolysis (1)
- quality assurance (1)
- quality of democracy (1)
- quality of life (QoL) (1)
- quantile forecasts (1)
- quantitative analysis (1)
- quantum Monte Carlo (1)
- quantum dot (1)
- quantum gravity (1)
- quantum optics (1)
- questionnaires (1)
- radiation (1)
- radiation sensitivity (1)
- radical (1)
- radical ion pair (1)
- radiopacity (1)
- radiotherapy (1)
- ray (1)
- reaction times (1)
- reactive intermediates (1)
- real life setting (1)
- real world evidence (1)
- reciprocal translocation (1)
- recombinant tissue-type plasminogen activator (1)
- reconstructive surgery (1)
- recording methods (1)
- rectum (1)
- refractory aGvHD (1)
- regulatory T cells (Treg) (1)
- regulatory capital (1)
- regulatory dendritic cells (1)
- reliability (1)
- renal imaging (1)
- repeated sprint (1)
- reprogamming of host cell metabolism (1)
- required hydrophilic–lipophilic balance (1)
- rereading (1)
- resettlement refugees (1)
- resistance (1)
- resonance theory (1)
- restriction factors (1)
- restrictive cardiomyopathy (1)
- resveratrol biosynthesis (1)
- retention interval (1)
- reticulate body (1)
- retinal pigment epithelium (1)
- retrospective (1)
- review (1)
- rhBMP–2 (1)
- ring-expansion reactions (1)
- ring-opening polymerization (1)
- ripk1 (1)
- ripk3 (1)
- risk society (1)
- risk stratification (1)
- robust control (1)
- rulebased analysis (1)
- ruthenium (1)
- sPEG (1)
- saccades (1)
- sacha inchi oil (1)
- sample storage (1)
- saproxylic organisms (1)
- sarcomere (1)
- satellite formation flying (1)
- satellite remote sensing (1)
- scaffold (1)
- search (1)
- seco-NIQs-Naphthylisoindolinone (1)
- secreted effectors (1)
- segmental progeria (1)
- self-determination theory (1)
- semantic segmentation (1)
- semileptonic & radiative decays (1)
- sensor data (1)
- sensor supports (1)
- sentinel (1)
- sentinel prey (1)
- sepsis (1)
- sequence analysis (1)
- sequential addition (1)
- serotonin (1)
- serotonin deficiency (1)
- setting reaction (1)
- sex robots (1)
- short neuropeptide F (1)
- short-range JCT-coupling (1)
- short-range order (1)
- shoulder (1)
- shoulder pain (1)
- shyness (1)
- sigma boranes (1)
- signal specification (1)
- signalling (1)
- silica supraparticles (1)
- simple (1)
- simulation and modeling (1)
- simultaneous presentation paradigm (1)
- single arc (1)
- single cell anatomy (1)
- single photon (1)
- single-molecule tracking (1)
- sirolimus (1)
- site-specific protein modification (1)
- situation awareness (1)
- skeletal progenitor cells (1)
- skewness (1)
- skin model (1)
- sleep (1)
- slope bogs (1)
- small RNA (1)
- small intestinal submucosa scaffold (1)
- small-cell lung cancer (1)
- small-molecule activation (1)
- smart surfaces (1)
- snowboarder's ankle (1)
- snowboarder's fracture (1)
- soccer (football) (1)
- social anxiety disorder (1)
- sociophonetics (1)
- sodium (1)
- soft tissue sarcoma (1)
- soft x-ray photoemission (1)
- software (1)
- soil fauna (1)
- solar cells (1)
- solid tumors (1)
- solid-state NMR spectroscopy (1)
- solid-state emitters (1)
- solitary bees (1)
- solubility (1)
- solubility enhancement (1)
- solvent-dependent fluorescence yield (1)
- somatic mutations (1)
- somatosensory evoked potential (1)
- somatosensory temporal discrimination (1)
- somatostatin receptor (1)
- spa typing (1)
- spacer-controlled self-assembly (1)
- spacing effect (1)
- spatial analyses (1)
- spatial heterogeneity (1)
- spatial scale (1)
- species richness (1)
- species‐area hypothesis (1)
- specific heat (1)
- sphingomyelinase (1)
- sphingosine kinase (1)
- sphingosine kinase inhibitor SKI-II (1)
- sphingosine-1-phosphate (1)
- spin polarization (1)
- spin relaxation (1)
- spin transport (1)
- spinal muscular atrophy (1)
- spleen (1)
- split renal function (1)
- sporidia (1)
- standardized reporting (1)
- standing (1)
- starPEG (1)
- starPEG hydrogel (1)
- startle response (1)
- static vs. dynamic faces (1)
- statistical distributions (1)
- statistical models (1)
- steering (1)
- stem Cells (1)
- stem cell transplantation (1)
- stereospecific sythesis (1)
- stereotactic body radiation therapy (1)
- stereotactic irradiation (1)
- steric effects (1)
- steroid-resistant aGvHD (1)
- stigma (1)
- storage-pool diseases (1)
- strain rate (1)
- strength training (1)
- stress (1)
- stress fiber (1)
- stress tolerance (1)
- stromal vascular fraction (1)
- strong coupling (1)
- strong light matter coupling (1)
- structural disruption (1)
- structural restriction (1)
- structure-activity (1)
- structure-activity relationship (1)
- structure-activity relationships (1)
- structured illumination microscopy (1)
- subadditivity (1)
- subarachnoid hemorrhage (1)
- submicroscopic chromosome rearrangement (1)
- subsarcolemmal mitochondria (1)
- substandard and falsified medicines from the Congo (1)
- substituent (1)
- subsurface hydrology (1)
- sulfoimines (1)
- sulfur (1)
- super resolution microscopy (1)
- super-resolution fluorescence microscopy (1)
- super-resolution microscopy (1)
- superresolution (1)
- suppressor cells (1)
- suppressor mutation (1)
- surface functionalization (1)
- surface plasmon (1)
- surface transport (1)
- surface water (1)
- surgical and invasive medical procedures (1)
- surgical site infection (1)
- survival analysis (1)
- synapses (1)
- synchrotron radiation (1)
- synchrotron radiatoren (1)
- synergistic effect (1)
- synthetic biology (1)
- systematic affiliation (1)
- systematic drug targeting (1)
- targeted bisulfite sequencing (1)
- targeted therapies (1)
- taxonomy (1)
- telemedicine (1)
- temozolomide (1)
- temperature‐mediated resource exploitation hypothesis (1)
- temperature‐richness hypothesis (1)
- temporal discrimination threshold (1)
- temporal lobe epilepsy (1)
- tendon-derived stem cell (1)
- terrestrial LiDAR (1)
- theranostics (1)
- therapy (1)
- therapy response (1)
- therapy simulation (1)
- thermal remote sensing (1)
- thiol-ene (1)
- thrombo-inflammation (1)
- thrombosis (1)
- tight junctions (1)
- time lag (1)
- time series (1)
- time-resolved photoelectron spectroscopy (1)
- time-resolved spectroscopy (1)
- tisindoline (1)
- top-down processing (1)
- topminnow (1)
- total body irradiation/busulfan (1)
- toxicity (1)
- trans-acting 2'-5' adenylyl transferase ribozymes (1)
- transcranial magnetic simulation (TMS) (1)
- transcription (1)
- transcription deficiency (1)
- transcriptome (1)
- transfer hydrogenation (1)
- transient absorption (1)
- transient dynamics (1)
- transient elastography (1)
- transient ischemic attack (1)
- transient middle cerebral artery occlusion (1)
- transition metal (1)
- transition metall dichalcogenide monolayer (1)
- transmission (1)
- transplantation (1)
- transposable elements (1)
- tree cavities (1)
- triacylglycerides (1)
- triarylboranes (1)
- triple bonds (1)
- triquinacene derivatives (1)
- trivalent boron (1)
- trypanosomes (1)
- tryptophan hydroxylase 2 (1)
- tumor burden (1)
- tumor control probability (1)
- tumor heterogeneity (1)
- tumor suppressor miRNA (1)
- tumour (1)
- tumour-necrosis factors (1)
- two-component (1)
- two-photon absorption (1)
- tyloses (1)
- type VII secretion system (1)
- ubiquitin ligase (1)
- ubiquitylation (ubiquitination) (1)
- uncanny valley (1)
- uncertainties (1)
- uncertainty (1)
- uneven-aged mountainous (1)
- unmanaged broadleaved forests (1)
- unnecessary alarm (1)
- unsaturated fatty acids (1)
- upconversion (1)
- uptake (1)
- urban environments (1)
- uremic toxins (1)
- urinary tract infections (1)
- vaccinia (1)
- variability (1)
- vascularization (1)
- vasculitis (1)
- verdünnt magnetische Halbleiter (1)
- vertebral body (1)
- vertical and radial variation (1)
- very high energies (VHE) (1)
- very long-chain aliphatic compounds (1)
- vessel lumen diameter (1)
- vessel wall resident stem cells (1)
- vestibular schwannoma (1)
- viability (1)
- video laryngoscopy (1)
- virotherapy (1)
- virtual isocenter (1)
- virus (1)
- viruses (1)
- visual orientation (1)
- visual perception (1)
- visual realism (1)
- vitamin D (1)
- vitamins (1)
- vocational education (1)
- voice-face matching (1)
- volume overload (1)
- walking (1)
- waste sorting (1)
- water balance (1)
- watershed (1)
- weightlifting (1)
- well-being (1)
- white matter lesions (1)
- whole-genome duplication (1)
- whole-genome sequencing (1)
- wild bees (1)
- wood anatomy (1)
- work (1)
- work capacity evaluation (1)
- work engagement (1)
- work performance (1)
- youth (1)
- zeitaufgelöste Spektroskopie (1)
- zielgerichtete Behandlung (1)
- zinc oxide (1)
- zinc oxide nanoparticles (1)
- zonal construct (1)
- zooming (1)
- État d'Imo (1)
- β3 adrenergic receptor (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (88)
- Graduate School of Life Sciences (51)
- Physikalisches Institut (38)
- Institut für Psychologie (29)
- Institut für Anorganische Chemie (27)
- Institut für Organische Chemie (27)
- Medizinische Klinik und Poliklinik II (25)
- Institut für deutsche Philologie (24)
- Neuphilologisches Institut - Moderne Fremdsprachen (24)
- Neurologische Klinik und Poliklinik (24)
Schriftenreihe
Sonstige beteiligte Institutionen
- VolkswagenStiftung (24)
- Johns Hopkins School of Medicine (2)
- Bio-Imaging Center Würzburg (1)
- CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - the development agency of the Brazilian Federal Government (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg (1)
- DAAD - Deutscher Akademischer Austauschdienst (1)
- Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany (1)
- Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden (1)
- Department of Medicine A, University Hospital of Münster, Münster, Germany (1)
- Ernst Strüngmann Institute for Neuroscience in Cooperation with Max Planck Society (ESI) (1)
ResearcherID
- B-4606-2017 (1)
Evolutionary conserved networks of human height identify multiple Mendelian causes of short stature
(2019)
Height is a heritable and highly heterogeneous trait. Short stature affects 3% of the population and in most cases is genetic in origin. After excluding known causes, 67% of affected individuals remain without diagnosis. To identify novel candidate genes for short stature, we performed exome sequencing in 254 unrelated families with short stature of unknown cause and identified variants in 63 candidate genes in 92 (36%) independent families. Based on systematic characterization of variants and functional analysis including expression in chondrocytes, we classified 13 genes as strong candidates. Whereas variants in at least two families were detected for all 13 candidates, two genes had variants in 6 (UBR4) and 8 (LAMA5) families, respectively. To facilitate their characterization, we established a clustered network of 1025 known growth and short stature genes, which yielded 29 significantly enriched clusters, including skeletal system development, appendage development, metabolic processes, and ciliopathy. Eleven of the candidate genes mapped to 21 of these clusters, including CPZ, EDEM3, FBRS, IFT81, KCND1, PLXNA3, RASA3, SLC7A8, UBR4, USP45, and ZFHX3. Fifty additional growth-related candidates we identified await confirmation in other affected families. Our study identifies Mendelian forms of growth retardation as an important component of idiopathic short stature.
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL conformation in living cells. Using this single-cell FRET approach, we demonstrate that (i) Wnt ligands induce open DVL conformation, (ii) DVL variants that are predominantly open, show more even subcellular localization and more efficient membrane recruitment by Frizzled (FZD) and (iii) Casein kinase 1 ɛ (CK1ɛ) has a key regulatory function in DVL conformational dynamics. In silico modeling and in vitro biophysical methods explain how CK1ɛ-specific phosphorylation events control DVL conformations via modulation of the PDZ domain and its interaction with DVL C-terminus. In summary, our study describes an experimental tool for DVL conformational sampling in living cells and elucidates the essential regulatory role of CK1ɛ in DVL conformational dynamics.
Preclinical studies point to a pivotal role of the orexin 1 (OX1) receptor in arousal and fear learning and therefore suggest the HCRTR1 gene as a prime candidate in panic disorder (PD) with/without agoraphobia (AG), PD/AG treatment response, and PD/AG-related intermediate phenotypes. Here, a multilevel approach was applied to test the non-synonymous HCRTR1 C/T Ile408Val gene variant (rs2271933) for association with PD/AG in two independent case-control samples (total n = 613 cases, 1839 healthy subjects), as an outcome predictor of a six-weeks exposure-based cognitive behavioral therapy (CBT) in PD/AG patients (n = 189), as well as with respect to agoraphobic cognitions (ACQ) (n = 483 patients, n = 2382 healthy subjects), fMRI alerting network activation in healthy subjects (n = 94), and a behavioral avoidance task in PD/AG pre- and post-CBT (n = 271). The HCRTR1 rs2271933 T allele was associated with PD/AG in both samples independently, and in their meta-analysis (p = 4.2 × 10−7), particularly in the female subsample (p = 9.8 × 10−9). T allele carriers displayed a significantly poorer CBT outcome (e.g., Hamilton anxiety rating scale: p = 7.5 × 10−4). The T allele count was linked to higher ACQ sores in PD/AG and healthy subjects, decreased inferior frontal gyrus and increased locus coeruleus activation in the alerting network. Finally, the T allele count was associated with increased pre-CBT exposure avoidance and autonomic arousal as well as decreased post-CBT improvement. In sum, the present results provide converging evidence for an involvement of HCRTR1 gene variation in the etiology of PD/AG and PD/AG-related traits as well as treatment response to CBT, supporting future therapeutic approaches targeting the orexin-related arousal system.
Zinc (Zn2+) can modulate platelet and coagulation activation pathways, including fibrin formation. Here, we studied the (patho)physiological consequences of abnormal platelet Zn2+ storage and release. To visualize Zn2+ storage in human and mouse platelets, the Zn2+ specific fluorescent dye FluoZin3 was used. In resting platelets, the dye transiently accumulated into distinct cytosolic puncta, which were lost upon platelet activation. Platelets isolated from Unc13d−/− mice, characterized by combined defects of α/δ granular release, showed a markedly impaired Zn2+ release upon activation. Platelets from Nbeal2−/− mice mimicking Gray platelet syndrome (GPS), characterized by primarily loss of the α-granule content, had strongly reduced Zn2+ levels, which was also confirmed in primary megakaryocytes. In human platelets isolated from patients with GPS, Hermansky-Pudlak Syndrome (HPS) and Storage Pool Disease (SPD) altered Zn2+ homeostasis was detected. In turbidity and flow based assays, platelet-dependent fibrin formation was impaired in both Nbeal2−/− and Unc13d−/− mice, and the impairment could be partially restored by extracellular Zn2+. Altogether, we conclude that the release of ionic Zn2+ store from secretory granules upon platelet activation contributes to the procoagulant role of Zn2+ in platelet-dependent fibrin formation.
B cell development in bone marrow is a precisely regulated complex process. Through successive stages of differentiation, which are regulated by a multitude of signaling pathways and an array of lineage-specific transcription factors, the common lymphoid progenitors ultimately give rise to mature B cells. Similar to early thymocyte development in the thymus, early B cell development in bone marrow is critically dependent on IL-7 signaling. During this IL-7-dependent stage of differentiation, several transcription factors, such as E2A, EBF1, and Pax5, among others, play indispensable roles in B lineage specification and maintenance. Although recent studies have implicated several other transcription factors in B cell development, the role of NFATc1 in early B cell developmental stages is not known. Here, using multiple gene-manipulated mouse models and applying various experimental methods, we show that NFATc1 activity is vital for early B cell differentiation. Lack of NFATc1 activity in pro-B cells suppresses EBF1 expression, impairs immunoglobulin gene rearrangement, and thereby preBCR formation, resulting in defective B cell development. Overall, deficiency in NFATc1 activity arrested the pro-B cell transition to the pre-B cell stage, leading to severe B cell lymphopenia. Our findings suggest that, along with other transcription factors, NFATc1 is a critical component of the signaling mechanism that facilitates early B cell differentiation.
Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. We determine the directional effect of gene expression on disease risk measured based on single and multiple eQTL. In addition, using a gene-based test of association that considers eQTL from multiple tissues, we identify seven (and four) regions with variants associated with overall (and ER-negative) breast cancer risk, which were not reported in previous GWAS. Further investigation of the function of the implicated genes in breast and immune cells may provide insights into the etiology of breast cancer.
The mechanisms behind carbon dioxide (CO2) dependency in non-autotrophic bacterial isolates are unclear. Here we show that the Staphylococcus aureus mpsAB operon, known to play a role in membrane potential generation, is crucial for growth at atmospheric CO2 levels. The genes mpsAB can complement an Escherichia coli carbonic anhydrase (CA) mutant, and CA from E. coli can complement the S. aureus delta-mpsABC mutant. In comparison with the wild type, S. aureus mps mutants produce less hemolytic toxin and are less virulent in animal models of infection. Homologs of mpsA and mpsB are widespread among bacteria and are often found adjacent to each other on the genome. We propose that MpsAB represents a dissolved inorganic carbon transporter, or bicarbonate concentrating system, possibly acting as a sodium bicarbonate cotransporter.
The NEDD8-activating enzyme (NAE) inhibitor MLN4924 inhibits cullin-RING ubiquitin ligase complexes including the SKP1-cullin-F-box E3 ligase βTrCP. MLN4924 therefore inhibits also the βTrCP-dependent activation of the classical and the alternative NFĸB pathway. In this work, we found that a subgroup of multiple myeloma cell lines (e.g., RPMI-8226, MM.1S, KMS-12BM) and about half of the primary myeloma samples tested are sensitized to TNF-induced cell death by MLN4924. This correlated with MLN4924-mediated inhibition of TNF-induced activation of the classical NFκB pathway and reduced the efficacy of TNF-induced TNFR1 signaling complex formation. Interestingly, binding studies revealed a straightforward correlation between cell surface TNFR1 expression in multiple myeloma cell lines and their sensitivity for MLN4924/TNF-induced cell death. The cell surface expression levels of TNFR1 in the investigated MM cell lines largely correlated with TNFR1 mRNA expression. This suggests that the variable levels of cell surface expression of TNFR1 in myeloma cell lines are decisive for TNF/MLN4924 sensitivity. Indeed, introduction of TNFR1 into TNFR1-negative TNF/MLN4924-resistant KMS-11BM cells, was sufficient to sensitize this cell line for TNF/MLN4924-induced cell death. Thus, MLN4924 might be especially effective in myeloma patients with TNFR1+ myeloma cells and a TNFhigh tumor microenvironment.
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C, FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing studies. We used the Oncoarray project to genotype two truncating FANCC variants (p.R185X and p.R548X) in 64,760 breast cancer cases and 49,793 controls of European descent. FANCC mutations were observed in 25 cases (14 with p.R185X, 11 with p.R548X) and 26 controls (18 with p.R185X, 8 with p.R548X). There was no evidence of an association with the risk of breast cancer, neither overall (odds ratio 0.77, 95%CI 0.44–1.33, p = 0.4) nor by histology, hormone receptor status, age or family history. We conclude that the breast cancer risk association of these two FANCC variants, if any, is much smaller than for BRCA1, BRCA2 or PALB2 mutations. If this applies to all truncating variants in FANCC it would suggest there are differences between FA genes in their roles on breast cancer risk and demonstrates the merit of large consortia for clarifying risk associations of rare variants.
Surgical extrusion is a recognised treatment option for teeth that have insufficient coronal tooth structure remaining due to deep caries, resorption or traumatic injury. However, the technique has not been widely adopted, arguably because extraction of a severely compromised tooth may be difficult to achieve in a gentle and predictable way. In this paper, we present our novel approach to surgical extrusion and subsequent management of teeth using a vertical extraction system (Benex), which has become the method of choice in the authors' practice for many teeth that would otherwise be deemed unrestorable. We describe the clinical procedure in detail and discuss the advantages and disadvantages compared to alternative approaches, including surgical crown lengthening and orthodontic extrusion.
C9ORF72 mutations are the most common cause of familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). MRI studies have investigated structural changes in C9ORF72-associated FTLD (C9FTLD) and provided first insights about a prominent involvement of the thalamus and the cerebellum. Our multicenter, 18F-fluorodeoxyglucose positron-emission tomography study of 22 mutation carriers with FTLD, 22 matched non-carriers with FTLD, and 23 cognitively healthy controls provided valuable insights into functional changes in C9FTLD: compared to non-carriers, mutation carriers showed a significant reduction of glucose metabolism in both thalami, underscoring the key role of the thalamus in C9FTLD. Thalamic metabolism did not correlate with disease severity, duration of disease, or the presence of psychotic symptoms. Against our expectations we could not demonstrate a cerebellar hypometabolism in carriers or non-carriers. Future imaging and neuropathological studies in large patient cohorts are required to further elucidate the central role of the thalamus in C9FTLD.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects 1 in ~350 individuals. Genetic association studies have established ALS as a multifactorial disease with heritability estimated at ~61%, and recent studies show a prominent role for rare variation in its genetic architecture. To identify rare variants associated with disease onset we performed exome array genotyping in 4,244 cases and 3,106 controls from European cohorts. In this largest exome-wide study of rare variants in ALS to date, we performed single-variant association testing, gene-based burden, and exome-wide individual set-unique burden (ISUB) testing to identify single or aggregated rare variation that modifies disease risk. In single-variant testing no variants reached exome-wide significance, likely due to limited statistical power. Gene-based burden testing of rare non-synonymous and loss-of-function variants showed NEK1 as the top associated gene. ISUB analysis did not show an increased exome-wide burden of deleterious variants in patients, possibly suggesting a more region-specific role for rare variation. Complete summary statistics are released publicly. This study did not implicate new risk loci, emphasizing the immediate need for future large-scale collaborations in ALS that will expand available sample sizes, increase genome coverage, and improve our ability to detect rare variants associated to ALS.
MYC paralogs are frequently activated in small cell lung cancer (SCLC) but represent poor drug targets. Thus, a detailed mapping of MYC-paralog-specific vulnerabilities may help to develop effective therapies for SCLC patients. Using a unique cellular CRISPR activation model, we uncover that, in contrast to MYCN and MYCL, MYC represses BCL2 transcription via interaction with MIZ1 and DNMT3a. The resulting lack of BCL2 expression promotes sensitivity to cell cycle control inhibition and dependency on MCL1. Furthermore, MYC activation leads to heightened apoptotic priming, intrinsic genotoxic stress and susceptibility to DNA damage checkpoint inhibitors. Finally, combined AURK and CHK1 inhibition substantially prolongs the survival of mice bearing MYC-driven SCLC beyond that of combination chemotherapy. These analyses uncover MYC-paralog-specific regulation of the apoptotic machinery with implications for genotype-based selection of targeted therapeutics in SCLC patients.
Animals must slow or halt locomotion to integrate sensory inputs or to change direction. In Caenorhabditis elegans, the GABAergic and peptidergic neuron RIS mediates developmentally timed quiescence. Here, we show RIS functions additionally as a locomotion stop neuron. RIS optogenetic stimulation caused acute and persistent inhibition of locomotion and pharyngeal pumping, phenotypes requiring FLP-11 neuropeptides and GABA. RIS photoactivation allows the animal to maintain its body posture by sustaining muscle tone, yet inactivating motor neuron oscillatory activity. During locomotion, RIS axonal Ca2+ signals revealed functional compartmentalization: Activity in the nerve ring process correlated with locomotion stop, while activity in a branch correlated with induced reversals. GABA was required to induce, and FLP-11 neuropeptides were required to sustain locomotion stop. RIS attenuates neuronal activity and inhibits movement, possibly enabling sensory integration and decision making, and exemplifies dual use of one cell across development in a compact nervous system.
Coordinated regulation of the lysosomal and autophagic systems ensures basal catabolism and normal cell physiology, and failure of either system causes disease. Here we describe an epigenetic rheostat orchestrated by c-MYC and histone deacetylases that inhibits lysosomal and autophagic biogenesis by concomitantly repressing the expression of the transcription factors MiT/TFE and FOXH1, and that of lysosomal and autophagy genes. Inhibition of histone deacetylases abates c-MYC binding to the promoters of lysosomal and autophagy genes, granting promoter occupancy to the MiT/TFE members, TFEB and TFE3, and/or the autophagy regulator FOXH1. In pluripotent stem cells and cancer, suppression of lysosomal and autophagic function is directly downstream of c-MYC overexpression and may represent a hallmark of malignant transformation. We propose that, by determining the fate of these catabolic systems, this hierarchical switch regulates the adaptive response of cells to pathological and physiological cues that could be exploited therapeutically.
Migration and interactions of immune cells are routinely studied by time-lapse microscopy of in vitro migration and confrontation assays. To objectively quantify the dynamic behavior of cells, software tools for automated cell tracking can be applied. However, many existing tracking algorithms recognize only rather short fragments of a whole cell track and rely on cell staining to enhance cell segmentation. While our previously developed segmentation approach enables tracking of label-free cells, it still suffers from frequently recognizing only short track fragments. In this study, we identify sources of track fragmentation and provide solutions to obtain longer cell tracks. This is achieved by improving the detection of low-contrast cells and by optimizing the value of the gap size parameter, which defines the number of missing cell positions between track fragments that is accepted for still connecting them into one track. We find that the enhanced track recognition increases the average length of cell tracks up to 2.2-fold. Recognizing cell tracks as a whole will enable studying and quantifying more complex patterns of cell behavior, e.g. switches in migration mode or dependence of the phagocytosis efficiency on the number and type of preceding interactions. Such quantitative analyses will improve our understanding of how immune cells interact and function in health and disease.
Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure function relationship of alien/anarchic limb was investigated in multi centric structural magnetic resonance imaging (MRI) data. Whole-group and single subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture. (C) 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Astrophysical sources of gravitational waves, such as binary neutron star and black hole mergers or core-collapse supernovae, can drive relativistic outflows, giving rise to non-thermal high-energy emission. High-energy neutrinos are signatures of such outflows. The detection of gravitational waves and high-energy neutrinos from common sources could help establish the connection between the dynamics of the progenitor and the properties of the outflow. We searched for associated emission of gravitational waves and high-energy neutrinos from astrophysical transients with minimal assumptions using data from Advanced LIGO from its first observing run O1, and data from the Antares and IceCube neutrino observatories from the same time period. We focused on candidate events whose astrophysical origins could not be determined from a single messenger. We found no significant coincident candidate, which we used to constrain the rate density of astrophysical sources dependent on their gravitational-wave and neutrino emission processes.
One of the main objectives of the ANTARES telescope is the search for point- like neutrino sources. Both the pointing accuracy and the angular resolution of the detector are important in this context and a reliableway to evaluate this performance is needed. In order to measure the pointing accuracy of the detector, one possibility is to study the shadow of the Moon, i. e. the deficit of the atmospheric muon flux from the direction of the Moon induced by the absorption of cosmic rays. Analysing the data taken between 2007 and 2016, theMoon shadow is observed with 3.5s statistical significance. The detector angular resolution for downwardgoing muons is 0.73. +/- 0.14.. The resulting pointing performance is consistent with the expectations. An independent check of the telescope pointing accuracy is realised with the data collected by a shower array detector onboard of a ship temporarily moving around the ANTARES location.
The ANTARES neutrino telescope has an energy threshold of a few tens of GeV. This allows to study the phenomenon of atmospheric muon neutrino disappearance due to neutrino oscillations. In a similar way, constraints on the 3+1 neutrino model, which foresees the existence of one sterile neutrino, can be inferred. Using data collected by the ANTARES neutrino telescope from 2007 to 2016, a new measurement of m 2 and (23) has been performed which is consistent with world best-fit values and constraints on the 3+1 neutrino model have been derived.
We consider the process of muon-electron elastic scattering, which has been proposed as an ideal framework to measure the running of the electromagnetic coupling constant at space-like momenta and determine the leading-order hadronic contribution to the muon g-2 (MUonE experiment). We compute the next-to-leading (NLO) contributions due to QED and purely weak corrections and implement them into a fully differential Monte Carlo event generator, which is available for first experimental studies. We show representative phenomenological results of interest for the MUonE experiment and examine in detail the impact of the various sources of radiative corrections under different selection criteria, in order to study the dependence of the NLO contributions on the applied cuts. The study represents the first step towards the realisation of a high-precision Monte Carlo code necessary for data analysis.
The Best for the Most Important: Maintaining a Pristine Proteome in Stem and Progenitor Cells
(2019)
Pluripotent stem cells give rise to reproductively enabled offsprings by generating progressively lineage-restricted multipotent stem cells that would differentiate into lineage-committed stem and progenitor cells. These lineage-committed stem and progenitor cells give rise to all adult tissues and organs. Adult stem and progenitor cells are generated as part of the developmental program and play critical roles in tissue and organ maintenance and/or regeneration. The ability of pluripotent stem cells to self-renew, maintain pluripotency, and differentiate into a multicellular organism is highly dependent on sensing and integrating extracellular and extraorganismal cues. Proteins perform and integrate almost all cellular functions including signal transduction, regulation of gene expression, metabolism, and cell division and death. Therefore, maintenance of an appropriate mix of correctly folded proteins, a pristine proteome, is essential for proper stem cell function. The stem cells' proteome must be pristine because unfolded, misfolded, or otherwise damaged proteins would interfere with unlimited self-renewal, maintenance of pluripotency, differentiation into downstream lineages, and consequently with the development of properly functioning tissue and organs. Understanding how various stem cells generate and maintain a pristine proteome is therefore essential for exploiting their potential in regenerative medicine and possibly for the discovery of novel approaches for maintaining, propagating, and differentiating pluripotent, multipotent, and adult stem cells as well as induced pluripotent stem cells. In this review, we will summarize cellular networks used by various stem cells for generation and maintenance of a pristine proteome. We will also explore the coordination of these networks with one another and their integration with the gene regulatory and signaling networks.
KM3NeT will be a network of deep-sea neutrino telescopes in the Mediterranean Sea. The KM3NeT/ARCA detector, to be installed at the Capo Passero site (Italy), is optimised for the detection of high-energy neutrinos of cosmic origin. Thanks to its geographical location on the Northern hemisphere, KM3NeT/ARCA can observe upgoing neutrinos from most of the Galactic Plane, including the Galactic Centre. Given its effective area and excellent pointing resolution, KM3NeT/ARCA will measure or significantly constrain the neutrino flux from potential astrophysical neutrino sources. At the same time, it will test flux predictions based on gamma-ray measurements and the assumption that the gamma-ray flux is of hadronic origin. Assuming this scenario, discovery potentials and sensitivities for a selected list of Galactic sources and to generic point sources with an E-2 spectrum are presented. These spectra are assumed to be time independent. The results indicate that an observation with 3 sigma significance is possible in about six years of operation for the most intense sources, such as Supernovae Remnants RX J1713.7-3946 and Vela Jr. If no signal will be found during this time, the fraction of the gamma-ray flux coming from hadronic processes can be constrained to be below 50% for these two objects. (C) 2019 The Authors. Published by Elsevier B.V.
We consider the computation of volumes contained in a spatial slice of AdS(3) in terms of observables in a dual CFT. Our main tool is kinematic space, defined either from the bulk perspective as the space of oriented bulk geodesics, or from the CFT perspective as the space of entangling intervals. We give an explicit formula for the volume of a general region in a spatial slice of AdS(3) as an integral over kinematic space. For the region lying below a geodesic, we show how to write this volume purely in terms of entangling entropies in the dual CFT. This expression is perhaps most interesting in light of the complexity = volume proposal, which posits that complexity of holographic quantum states is computed by bulk volumes. An extension of this idea proposes that the holographic subregion complexity of an interval, defined as the volume under its Ryu-Takayanagi surface, is a measure of the complexity of the corresponding reduced density matrix. If this is true, our results give an explicit relationship between entanglement and subregion complexity in CFT, at least in the vacuum. We further extend many of our results to conical defect and BTZ black hole geometries.
Background and Objective: Staphylococcus aureus is one of the major pathogens of nosocomial infections as wells as community-acquired (CA) infections worldwide. So far, large-scale comprehensive molecular and epidemiological characterisation of S. aureus from very diverse settings has not been carried out in India. The objective of this study is to evaluate the molecular, epidemiological and virulence characteristics of S. aureus in both community and hospital settings in Chennai, southern India. Methods: S. aureus isolates were obtained from four different groups (a) healthy individuals from closed community settings, (b) inpatients from hospitals, (c) outpatients from hospitals, representing isolates of hospital-community interface and (d) HIV-infected patients to define isolates associated with the immunocompromised. Antibiotic susceptibility testing, multiplex polymerase chain reactions for detection of virulence and resistance determinants, molecular typing including Staphylococcal cassette chromosome mec (SCCmec) and agr typing, were carried out. Sequencing-based typing was done using spa and multilocus sequence typing (MLST) methods. Clonal complexes (CC) of hospital and CA methicillin-resistant S. aureus (MRSA) were identified and compared for virulence and resistance.
Results and Conclusion: A total of 769 isolates of S. aureus isolates were studied. The prevalence of MRSA was found to be 7.17%, 81.67%, 58.33% and 22.85% for groups a, b, c and d, respectively. Of the four SCCmec types (I, III, IV and V) detected, SCCmec V was found to be predominant. Panton-Valentine leucocidin toxin genes were detected among MRSA isolates harbouring SCCmec IV and V. A total of 78 spa types were detected, t657 being the most prevalent. 13 MLST types belonging to 9 CC were detected. CC1 (ST-772, ST-1) and CC8 (ST238, ST368 and ST1208) were found to be predominant among MRSA. CA-MRSA isolates with SCCmec IV and V were isolated from all study groups including hospitalised patients and were found to be similar by molecular tools. This shows that CA MRSA has probably infiltrated into the hospital settings.
Background
Shotgun metagenomes contain a sample of all the genomic material in an environment, allowing for the characterization of a microbial community. In order to understand these communities, bioinformatics methods are crucial. A common first step in processing metagenomes is to compute abundance estimates of different taxonomic or functional groups from the raw sequencing data.
Given the breadth of the field, computational solutions need to be flexible and extensible, enabling the combination of different tools into a larger pipeline.
Results
We present NGLess and NG-meta-profiler. NGLess is a domain specific language for describing next-generation sequence processing pipelines. It was developed with the goal of enabling user-friendly computational reproducibility. It provides built-in support for many common operations on sequencing data and is extensible with external tools with configuration files.
Using this framework, we developed NG-meta-profiler, a fast profiler for metagenomes which performs sequence preprocessing, mapping to bundled databases, filtering of the mapping results, and profiling (taxonomic and functional). It is significantly faster than either MOCAT2 or htseq-count and (as it builds on NGLess) its results are perfectly reproducible.
Conclusions
NG-meta-profiler is a high-performance solution for metagenomics processing built on NGLess. It can be used as-is to execute standard analyses or serve as the starting point for customization in a perfectly reproducible fashion.
NGLess and NG-meta-profiler are open source software (under the liberal MIT license) and can be downloaded from https://ngless.embl.de or installed through bioconda.
Background
Temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) is a common pharmaco-resistant epilepsy referred for adult epilepsy surgery. Though associated with prolonged febrile seizures (FS) in childhood, the neurobiological basis for this relationship is not fully understood and currently no preventive or curative therapies are available. DNA methylation, an epigenetic mechanism catalyzed by DNA methyltransferases (DNMTs), potentially plays a pivotal role in epileptogenesis associated with FS. In an attempt to start exploring this notion, the present cross-sectional pilot study investigated whether global DNA methylation levels (5-mC and 5-hmC markers) and DNMT isoforms (DNMT1, DNMT3a1, and DNMT3a2) expression would be different in hippocampal and neocortical tissues between controls and TLE patients with or without a history of FS.
Results
We found that global DNA methylation levels and DNMT3a2 isoform expression were lower in the hippocampus for all TLE groups when compared to control patients, with a more significant decrease amongst the TLE groups with a history of FS. Interestingly, we showed that DNMT3a1 expression was severely diminished in the hippocampus of TLE patients with a history of FS in comparison with control and other TLE groups. In the neocortex, we found a higher expression of DNMT1 and DNMT3a1 as well as increased levels of global DNA methylation for all TLE patients compared to controls.
Conclusion
Together, the findings of this descriptive cross-sectional pilot study demonstrated brain region-specific changes in DNMT1 and DNMT3a isoform expression as well as global DNA methylation levels in human TLE with or without a history of FS. They highlighted a specific implication of DNMT3a isoforms in TLE after FS. Therefore, longitudinal studies that aim at targeting DNMT3a isoforms to evaluate the potential causal relationship between FS and TLE or treatment of FS-induced epileptogenesis seem warranted.
Background
Providing adequate healthcare to newly arrived refugees is considered one of the significant challenges for the German healthcare system. These refugees can be classified mainly into two groups: asylum seekers (who have applied for asylum after arrival in Germany and are waiting for the refugee-status decision) and resettlement refugees (who have already been granted asylum status before arriving in Germany). Whereas earlier studies have explored the health status of asylum seekers especially in terms of mental and behavioural disorders and infectious diseases without distinguishing between these two groups, our study aims to evaluate possible relationships of asylum status and medical needs of these two groups with a special focus on mental and behavioural disorders and infectious diseases.
Methods
In this retrospective observational study, collected data on all asylum-seeker and resettlement-refugee patients (N = 2252) of a German reception centre (August 2017 to August 2018) is analysed by absolute and relative frequencies and medians. Patient data, collected by chart review, include age, gender, country of origin, asylum status, and diagnoses (ICD-10). To describe the relationship between sociodemographic factors (including asylum status) and diagnoses, we used tests of significance and bivariate correlations with Spearman correlation coefficients. All collected data are pseudonymised.
Results
Of all 2252 patients, 43% were resettlement refugees. In almost all ICD-10 categories, asylum seekers received significantly more diagnoses than resettlement refugees. According to our data, asylum seekers presented with mental and behavioural disorders nine times more often (9%) than resettlement refugees (1%). In the case of infectious diseases, the results are mixed: asylum seekers were twice as frequently (11%) diagnosed with certain infectious and parasitic diseases than resettlement refugees (5%), but resettlement refugees were treated twice as often (22% of the asylum seekers and 41% of the resettlement refugees) for diseases of the respiratory system, of which 84% were acute respiratory infections (in both groups).
Conclusion
This study indicates that patients with unregulated migration more frequently present symptoms of psychiatric diseases and somatoform symptoms than resettlement refugees. A health policy approach within migration policy should aim to enable persecuted persons to migrate under regulated and safe conditions.
Trial registration
German Clinical Trials Register: DRKS00013076, retrospectively registered on 29.09.2017.
Background
Panniculitis-like T-cell lymphoma is an uncommon type of non-Hodgkin lymphoma, occurring usually in the form of nodules within the subcutaneous fat tissue of the extremities or trunk. In the literature, subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is described as a distinct type of T-cell lymphoma with a variable clinical behavior, depending on molecular phenotype of T-cell receptor (TCR) and on the presence or absence of hemophagocytic syndrome.
Case presentation
We present a bioptic and autoptic case of a 65-years old Caucasian man with panniculitic T-cell lymphoma with morphological and immunohistochemical features of SPTCL, limited to the retroperitoneal and mesenteric mass, i.e. without any cutaneous involvement, and associated with severe hemophagocytic lymphohistiocytosis.
Conclusion
A panniculitic T-cell lymphoma with morphological and molecular features of SPTCL, which is limited to mesentery, i.e. does not involve subcutaneous fat, seems to be exceedingly rare.
Background
Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory disorder of the skeletal system of yet unknown etiology. Patients present with local bone pain and inflammation and - to our experience - often suffer from functional impairment with significant disabilities of daily life. The objective of this study was to assess physical activity, fitness and health-related quality of life (HRQOL) in adolescents with established diagnosis of CNO versus healthy controls (HC).
Methods
15 patients with CNO and 15 age and gender matched HC aged 13–18 years, completed questionnaires, performed an incremental exercise test with gas exchange measures up to voluntary fatigue and wore an accelerometer over 7 days at home to assess physical activity behavior.
Results
At the time of assessment, 5 CNO patients were in clinical, one in radiological and 5 in clinical and radiological remission. 7 did not receive any therapy at the time of assessment. The results of the exercise test and of the accelerometry did not show any significant difference between CNO and HC. However, reported sports participation was lower in patients with CNO and PedsQL3.0 and 4.0 showed significant lower values in most of the scores indicating reduced HRQOL.
Conclusion
Although most CNO patients showed a favorable course of disease without any relevant differences in objective measurements of physical activity and fitness versus HC at the time of assessment, questionnaires revealed perceived limitations. Further studies are needed to measure HRQOL and to validate questionnaires in patients with CNO against objective measures including more participants with a higher level of disease activity.
Background
The aim of this study was to review the patient rated outcome (PROM) of surgically treated fractures to the lateral process of the talus (LPTF) and identify factors influencing the outcome.
Methods
Retrospective study with a current follow-up. Eligible were all patients treated surgically for a LPTF (n = 23) with a minimum follow-up of one year. Demographics, medical history, trauma mechanism, fracture characteristics, concomitant injuries, treatment details, complications, return to work and sports were assessed retrospectively. The current follow-up included the VAS FA, Karlsson Score, and SF-12. The primary outcome was the VAS FA. Secondary aim was the identification of parameters influencing the PROMs.
Results
22 patients (96% follow-up) with a mean age of 32 ± 9 (18 to 49) years were included. 73% suffered a Hawkins Type 1, 23% a Type 2, and one patient a Type 3 fracture. 82% suffered concomitant injuries. 9% suffered minor surgical side infections, 50% developed symptomatic subtalar osteoarthritis. At final follow-up (44 ± 2 (12 to 97) months), the mean VAS FA Overall was 77 ± 21 (20 to 100), the Karlsson Score 72 ± 21 (34 to 97), and for the SF 12 the PCS 53 ± 8 (36 to 64) and the MCS 53 ± 7 (32 to 63). 50% of patients returned to their previous level of sports. Hawkins Type 1 fractures resulted in better VAS FA Overall score than Type 2 fractures. Posttraumatic subtalar osteoarthritis was the independent factor associated to a poor patient rated outcome (VAS FA, Karlsson Score).
Conclusion
After a follow-up of over 3.5 years, surgically treated LPTF resulted in only moderate results. 50% suffered posttraumatic symptomatic subtalar osteoarthritis, which was the primary independent parameter for a poor outcome following LPTF.
Level of evidence
Level III.
Background
Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with gene expression regulatory function, has been reported in all types of epithelial and haematological cancers. In particular, miR-221-5p alterations have been reported in PCa.
Methods
miRNA expression data was retrieved from a comprehensive publicly available dataset of 218 PCa patients (GSE21036) and miR-221-5p expression levels were analysed. The functional role of miR-221-5p was characterised in androgen- dependent and androgen- independent PCa cell line models (C4–2 and PC-3M-Pro4 cells) by miR-221-5p overexpression and knock-down experiments. The metastatic potential of highly aggressive PC-3M-Pro4 cells overexpressing miR-221-5p was determined by studying extravasation in a zebrafish model. Finally, the effect of miR-221-5p overexpression on the growth of PC-3M-Pro4luc2 cells in vivo was studied by orthotopic implantation in male Balb/cByJ nude mice and assessment of tumor growth.
Results
Analysis of microRNA expression dataset for human primary and metastatic PCa samples and control normal adjacent benign prostate revealed miR-221-5p to be significantly downregulated in PCa compared to normal prostate tissue and in metastasis compared to primary PCa. Our in vitro data suggest that miR-221-5p overexpression reduced PCa cell proliferation and colony formation. Furthermore, miR-221-5p overexpression dramatically reduced migration of PCa cells, which was associated with differential expression of selected EMT markers. The functional changes of miR-221-5p overexpression were reversible by the loss of miR-221-5p levels, indicating that the tumor suppressive effects were specific to miR-221-5p. Additionally, miR-221-5p overexpression significantly reduced PC-3M-Pro4 cell extravasation and metastasis formation in a zebrafish model and decreased tumor burden in an orthotopic mouse model of PCa.
Conclusions
Together these data strongly support a tumor suppressive role of miR-221-5p in the context of PCa and its potential as therapeutic target.
Background
The aim of this analysis was to model the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer.
Methods
The analysis is based on pooled data from two retrospective SBRT databases for pulmonary and hepatic metastases from 27 centers from Germany and Switzerland. Only patients with metastases from colorectal cancer were considered to avoid histology as a confounding factor. An illness-death model was employed to model the relationship between LC and OS.
Results
Three hundred eighty-eight patients with 500 metastatic lesions (lung n = 209, liver n = 291) were included and analyzed. Median follow-up time for local recurrence assessment was 12.1 months. Ninety-nine patients with 112 lesions experienced local failure. Seventy-one of these patients died after local failure. Median survival time was 27.9 months in all patients and 25.4 months versus 30.6 months in patients with and without local failure after SBRT. The baseline risk of death after local failure exceeds the baseline risk of death without local failure at 10 months indicating better survival with LC.
Conclusion
In CRC patients with lung or liver metastases, our findings suggest improved long-term OS by achieving metastatic disease control using SBRT in patients with a projected OS estimate of > 12 months.
Background
Airway management is crucial and, probably, even the most important key competence in anaesthesiology, which directly influences patient safety and outcome. However, high-quality research is rarely published and studies usually have different primary or secondary endpoints which impedes clear unbiased comparisons between studies. The aim of the present study was to gather and analyse primary and secondary endpoints in video laryngoscopy studies being published over the last ten years and to create a core set of uniform or homogeneous outcomes (COS).
Methods
Retrospective analysis. Data were identified by using MEDLINE® database and the terms “video laryngoscopy” and “video laryngoscope” limited to the years 2007 to 2017. A total of 3351 studies were identified by the applied search strategy in PubMed. Papers were screened by two anaesthesiologists independently to identify study endpoints. The DELPHI method was used for consensus finding.
Results
In the 372 studies analysed and included, 49 different outcome categories/columns were reported. The items “time to intubation” (65.86%), “laryngeal view grade” (44.89%), “successful intubation rate” (36.56%), “number of intubation attempts” (23.39%), “complications” (21.24%), and “successful first-pass intubation rate” (19.09%) were reported most frequently. A total of 19 specific parameters is recommended.
Conclusions
In recent video laryngoscopy studies, many different and inhomogeneous parameters were used as outcome descriptors/endpoints. Based on these findings, we recommend that 19 specific parameters (e.g., “time to intubation” (inserting the laryngoscope to first ventilation), “laryngeal view grade” (C&L and POGO), “successful intubation rate”, etc.) should be used in coming research to facilitate future comparisons of video laryngoscopy studies.
Background
The heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we investigated whether an empirical linear conversion of H/M ratios between camera systems with low-energy (LE) and medium-energy (ME) collimator is possible.
Methods
We included 18 patients with parkinsonism who were referred to one of the two participating molecular imaging facilities for the evaluation of cardiac sympathetic innervation by MIBG scintigraphy. Two consecutive planar image datasets were acquired with LE and ME collimators at 4 h after MIBG administration. Linear regression analyses were performed to describe the association between the H/M ratios gained with both collimator settings, and the accuracy of a linear transfer of the H/M ratio between collimators and across centers was assessed using a leave-one-out procedure.
Results
H/M ratios acquired with LE and ME collimators showed a strong linear relationship both within each imaging facility (R\(^2\) = 0.99, p < 0.001 and R\(^2\) = 0.90, p < 0.001) and across centers (H/M-LE = 0.41 × H/M-ME + 0.63, R\(^2\) = 0.97, p < 0.001). A linear conversion of H/M ratios between collimators and across centers was estimated to be very accurate (mean absolute error 0.05 ± 0.04; mean relative absolute error 3.2 ± 2.6%).
Conclusions
The present study demonstrates that a simple linear conversion of H/M ratios acquired with different collimators is possible with high accuracy. This should greatly facilitate the exchange of normative data between settings and pooling of data from different institutions.
Background
Increasing bacterial resistance to antibiotics is a serious problem worldwide. We sought to record the acquisition of antibiotic-resistant Escherichia coli (E. coli) in healthy infants in Northern Thailand and investigated potential determinants.
Methods
Stool samples from 142 infants after birth, at ages 2wk, 2mo, 4 to 6mo, and 1y, and parent stool samples were screened for E. coli resistance to tetracycline, ampicillin, co-trimoxazole, and cefazoline by culture, and isolates were further investigated for multiresistance by disc diffusion method. Pulsed-field gel electrophoresis was performed to identify persistent and transmitted strains. Genetic comparison of resistant and transmitted strains was done by multilocus sequence typing (MLST) and strains were further investigated for extra- and intra-intestinal virulence factors by multiplex PCR.
Results
Forty-seven (33%) neonatal meconium samples contained resistant E. coli. Prevalence increased continuously: After 1y, resistance proportion (tetracycline 80%, ampicillin 72%, co-trimoxazole 66%, cefazoline 35%) almost matched those in parents. In 8 infants (6%), identical E. coli strains were found in at least 3 sampling time points (suggesting persistence). Transmission of resistant E. coli from parents to child was observed in only 8 families. MLST showed high diversity. We could not identify any virulence genes or factors associated with persistence, or transmission of resistant E. coli. Full-term, vaginal birth and birth in rural hospital were identified as risk factors for early childhood colonization with resistant E. coli.
Conclusion
One third of healthy Thai neonates harboured antibiotic-resistant E. coli in meconium. The proportion of resistant E. coli increased during the first year of life almost reaching the value in adults. We hypothesize that enhancement of infection control measures and cautious use of antibiotics may help to control further increase of resistance.
Background
Colonization with Staphylococcus aureus has been identified as a risk for subsequent occurrence of infection. This study investigated the relationship between S. aureus colonization of patients and healthcare workers (HCWs), and subsequent surgical site infections (SSI).
Methods
Between December 2014 and September 2015, a total of 930 patients and 143 HCWs were enrolled from the Bugando Medical Centre and Sekou Toure hospital in Mwanza, Tanzania. On admission and discharge nasal swabs, with an additional of wound swab for those who developed SSI were collected from patients whereas HCWs were swabbed once. Identification and antimicrobial susceptibility testing were done by VITEK-MS and VITEK-2, respectively. Detection of Panton Valentine leukocidin (PVL) and mecA genes was done by PCR. S. aureus isolates were further characterized by spa typing and Multi-Locus Sequence Typing (MLST).
Results
Among 930 patients screened for S. aureus on admission, 129 (13.9%) were positive of which 5.4% (7/129) were methicillin-resistant S. aureus (MRSA). Amongst 363 patients rescreened on discharge, 301 patients had been tested negative on admission of whom 29 (9.6%) turned positive after their hospital stay. Three (10.3%) of the 29 acquired S. aureus were MRSA. Inducible Clindamycin resistance occurred more often among acquired S. aureus isolates than among isolates from admission [34.5% (10/29) vs. 17.1% (22/129), P = 0.018]. S. aureus contributed to 21.1% (n = 12) of the 57 cases of investigated SSIs among 536 patients followed. Seven out of eight S. aureus carriage/infection pairs had the same spa and sequence types. The previously reported dominant PVL-positive ST88 MRSA strain with spa type t690 was detected in patients and HCW.
Conclusion
A significant proportion of patients acquired S. aureus during hospitalization. The finding of more than 90% of S. aureus SSI to be of endogenous source underscores the need of improving infection prevention and control measures including screening and decolonization of high risk patients.
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today's technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics.
We review the physics opportunities of the Future Circular Collider, covering its e(+)e(-), pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries.
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries.
Narrow resonances decaying into WW, WZ or ZZ boson pairs are searched for in 139 fb(-1) of proton-proton collision data at a centre-of-mass energy of root s = 13TeV recorded with the ATLAS detector at the Large Hadron Collider from 2015 to 2018. The diboson system is reconstructed using pairs of high transverse momentum, large-radius jets. These jets are built from a combination of calorimeter- and tracker-inputs compatible with the hadronic decay of a boosted W or Z boson, using jet mass and substructure properties. The search is performed for diboson resonances with masses greater than 1.3TeV. No significant deviations from the background expectations are observed. Exclusion limits at the 95% confidence level are set on the production cross-section times branching ratio into dibosons for resonances in a range of theories beyond the Standard Model, with the highest excluded mass of a new gauge boson at 3.8TeV in the context of mass-degenerate resonances that couple predominantly to gauge bosons.
This paper describes a study of techniques for identifying Higgs bosons at high transverse momenta decaying into bottom-quark pairs, H -> b (b) over bar, for proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy root s = 13 TeV. These decays are reconstructed from calorimeter jets found with the anti-k(t) R = 1.0 jet algorithm. To tag Higgs bosons, a combination of requirements is used: b-tagging of R = 0.2 track-jets matched to the large-R calorimeter jet, and requirements on the jet mass and other jet substructure variables. The Higgs boson tagging efficiency and corresponding multijet and hadronic top-quark background rejections are evaluated using Monte Carlo simulation. Several benchmark tagging selections are defined for different signal efficiency targets. The modelling of the relevant input distributions used to tag Higgs bosons is studied in 36 fb(-1) of data collected in 2015 and 2016 using g -> b (b) over bar and Z(-> b (b) over bar)gamma event selections in data. Both processes are found to be well modelled within the statistical and systematic uncertainties.
The inclusive cross-section for jet production in association with a Z boson decaying into an electronpositron pair is measured as a function of the transverse momentum and the absolute rapidity of jets using 19.9 fb(-1) of root s = 8 TeV proton-proton collision data collected with the ATLAS detector at the Large Hadron Collider. The measured Z + jets cross-section is unfolded to the particle level. The cross-section is compared with state-of-the-art Standard Model calculations, including the next-to-leading-order and next-to-next-to-leading-order perturbative QCD calculations, corrected for non-perturbative and QED radiation effects. The results of the measurements cover final-state jets with transverse momenta up to 1 TeV, and show good agreement with fixed-order calculations.
This paper presents measurements of the W+->mu+nu and W-->mu-nu cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton-proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2fb(-1). The precision of the cross-section measurements varies between 0.8 and 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.
This paper presents measurements of charged-particle distributions sensitive to the properties of the underlying event in events containing a Z boson decaying into a muon pair. The data were obtained using the ATLAS detector at the LHC in proton-proton collisions at a centre-of-mass energy of 13 TeV with an integrated luminosity of 3.2 fb(-1). Distributions of the charged-particle multiplicity and of the charged-particle transverse momentum are measured in regions of the azimuth defined relative to the Z boson direction. The measured distributions are compared with the predictions of various Monte Carlo generators which implement different underyling event models. The Monte Carlo model predictions qualitatively describe the data well, but with some significant discrepancies.
This Letter describes the observation of the light-by-light scattering process, gamma gamma -> gamma gamma, in Pb + Pb collisions at root S-NN = 5.02 TeV. The analysis is conducted using a data sample corresponding to an integrated luminosity of 1.73 nb(-1), collected in November 2018 by the ATLAS experiment at the LHC. Light-by-light scattering candidates are selected in events with two photons produced exclusively, each with transverse energy E-T(gamma) > 3 GeV and pseudorapidity vertical bar eta(gamma)vertical bar < 2.4, diphoton invariant mass above 6 GeV, and small diphoton transverse momentum and acoplanarity. After applying all selection criteria, 59 candidate events are observed for a background expectation of 12 +/- 3 events. The observed excess of events over the expected background has a significance of 8.2 standard deviations. The measured fiducial cross section is 78 +/- 13(stat) +/- 7(syst) +/- 3(lumi) nb.
A search for a heavy charged-boson resonance decaying into a charged lepton (electron or muon) and a neutrino is reported. A data sample of 139 fb(-1) of proton-proton collisions at root s = 13 TeV collected with the ATLAS detector at the LHC during 2015-2018 is used in the search. The observed transverse mass distribution computed from the lepton and missing transverse momenta is consistent with the distribution expected from the Standard Model, and upper limits on the cross section for pp -> W'-> lv are extracted (l = e or mu). These vary between 1.3 pb and 0.05 tb depending on the resonance mass in the range between 0.15 and 7.0 TeV at 95% confidence level for the electron and muon channels combined. Gauge bosons with a mass below 6.0 and 5.1 TeV are excluded in the electron and muon channels, respectively, in a model with a resonance that has couplings to fermions identical to those of the Standard Model W boson. Cross-section limits are also provided for resonances with several fixed Gamma/m values in the range between 1% and 15%. Model-independent limits are derived in single-bin signal regions defined by a varying minimum transverse mass threshold. The resulting visible cross-section upper limits range between 4.6 (15) ph and 22 (22) ab as the threshold increases from 130 (110) GeV to 5.1 (5.1) TeV in the electron (muon) channel.
This paper reports on a search for electroweak diboson (WW/WZ/ZZ) production in association with a high-mass dijet system, using data from proton-proton collisions at a center-of-mass energy of N root s = 13 TeV. The data, corresponding to an integrated luminosity of 35.5 fb(-1), were recorded with the ATLAS detector in 2015 and 2016 at the Large Hadron Collider. The search is performed in final states in which one boson decays leptonically, and the other boson decays hadronically. The hadronically decaying W/Z boson is reconstructed as either two small-radius jets or one large-radius jet using jet substructure techniques. The electroweak production of WW/WZ/ZZ in association with two jets is measured with an observed (expected) significance of 2.7 (2.5) standard deviations, and the fiducial cross section is measured to be 45.1 +/- 8.6(stat.)(-14.6)(+15.9)(syst.) fb.
The momentum measurement capability of the ATLAS muon spectrometer relies fundamentally on the intrinsic single-hit spatial resolution of the monitored drift tube precision tracking chambers. Optimal resolution is achieved with a dedicated calibration program that addresses the specific operating conditions of the 354 000 high-pressure drift tubes in the spectrometer. The calibrations consist of a set of timing offsets and drift time to drift distance transfer relations, and result in chamber resolution functions. This paper describes novel algorithms to obtain precision calibrations from data collected by ATLAS in LHC Run 2 and from a gas monitoring chamber, deployed in a dedicated gas facility. The algorithm output consists of a pair of correction constants per chamber which are applied to baseline calibrations, and determined to be valid for the entire ATLAS Run 2. The final single-hit spatial resolution, averaged over 1172 monitored drift tube chambers, is 81.7 +/- 2.2 mu m.