Refine
Year of publication
- 2019 (696) (remove)
Document Type
- Journal article (487)
- Doctoral Thesis (163)
- Book article / Book chapter (23)
- Preprint (19)
- Conference Proceeding (1)
- Other (1)
- Report (1)
- Working Paper (1)
Language
- English (696) (remove)
Keywords
- Animal Studies (24)
- Cultural Animal Studies (24)
- Cultural Studies (24)
- Ecocriticism (24)
- Environmental Humanities (24)
- Human-Animal Studies (24)
- Literary Studies (24)
- boron (11)
- apoptosis (8)
- inflammation (7)
- Tissue Engineering (6)
- cancer (6)
- ischemic stroke (6)
- children (5)
- measles virus (5)
- tissue engineering (5)
- DNA methylation (4)
- Drosophila melanogaster (4)
- Hydrogel (4)
- Maschinelles Lernen (4)
- Neisseria meningitidis (4)
- Spektroskopie (4)
- Taufliege (4)
- cancer therapy (4)
- deep brain stimulation (4)
- infection (4)
- microbiome (4)
- multiple myeloma (4)
- sphingolipids (4)
- stroke (4)
- virtual reality (4)
- Übergangsmetalloxide (4)
- 3D tissue model (3)
- 3D-Druck (3)
- Ancistrocladaceae (3)
- Candida albicans (3)
- Chronobiologie (3)
- Elektrophysiologie (3)
- Exziton (3)
- Fluoreszenzmikroskopie (3)
- GABA (3)
- Genexpression (3)
- Leistungsbewertung (3)
- Maus (3)
- Megakaryozyt (3)
- Meningitis (3)
- Monte-Carlo (3)
- Physics (3)
- Raman-Spektroskopie (3)
- Schlaganfall (3)
- Serotonin (3)
- Soziale Wahrnehmung (3)
- Staphylococcus aureus (3)
- Survival (3)
- Ureaplasma parvum (3)
- Ureaplasma urealyticum (3)
- aging (3)
- blood–brain barrier (3)
- boranes (3)
- climate change (3)
- colorectal cancer (3)
- cytokines (3)
- cytotoxicity (3)
- death receptors (3)
- depression (3)
- epigenetics (3)
- genetics (3)
- gephyrin (3)
- in vitro (3)
- length of stenosis (3)
- leukemic cells (3)
- lysosome (3)
- machine learning (3)
- magnetic resonance imaging (3)
- metagenomics (3)
- migration (3)
- p53 (3)
- platelets (3)
- presence (3)
- psychiatric disorders (3)
- remote sensing (3)
- risk factors (3)
- stem cells (3)
- ubiquitin (3)
- 2Dimensionale Spektroskopie (2)
- 3D (2)
- 3D printing (2)
- AdS/CFT (2)
- Aggregation (2)
- Angst (2)
- Annotation (2)
- Anxiety (2)
- Aufmerksamkeit (2)
- B-MYB (2)
- Bees (2)
- Bilanzpolitik (2)
- Bildverarbeitung (2)
- Bioinformatik (2)
- Biomaterial (2)
- Biomedical engineering (2)
- Blutgerinnung (2)
- C-reactive protein (2)
- CXCR4 (2)
- Cancer (2)
- Channelrhodopsin (2)
- Chlamydia trachomatis (2)
- Colonization (2)
- Constraints (2)
- Cross-Section (2)
- Cryo-EM (2)
- DNA damage (2)
- Decay (2)
- Deutschland (2)
- Drosophila (2)
- EEA (2)
- Ecology (2)
- Exercise capacity (2)
- Expression (2)
- FKBP5 (2)
- GABAA receptors (2)
- Gedächtnis (2)
- HBMEC (2)
- HBV (2)
- HIV (2)
- Hadron colliders (2)
- Halbleiter (2)
- HeLa cells (2)
- Imaging techniques (2)
- Impact (2)
- Implantat (2)
- In vitro (2)
- Inhibitor (2)
- KDELR2 (2)
- Kernspintomografie (2)
- Knochenzement (2)
- Kognition (2)
- Lungenkrebs (2)
- MLST (2)
- MSC (2)
- Machine Learning (2)
- Melanoma (2)
- Merocyanine (2)
- Metabolomics (2)
- Metadynamics (2)
- Methylation (2)
- Mitose (2)
- Molekulargenetik (2)
- Muscarinrezeptor (2)
- NHC (2)
- Naphthylisochinolinalkaloide (2)
- Neurons (2)
- Optimierung (2)
- Optogenetik (2)
- PIP2 (2)
- Pair Production (2)
- Parton Distributions (2)
- Parton distributions (2)
- Perylenderivate (2)
- Pontryagin maximum principle (2)
- Positronen-Emissions-Tomografie (2)
- Quanten-Vielteilchensysteme (2)
- Quantum Information (2)
- Quantum many-body systems (2)
- RNA-seq (2)
- Radiative-corrections (2)
- Reduction (2)
- Regenerative Medizin (2)
- Röntgen-Photoelektronenspektroskopie (2)
- S-ADAPT (2)
- SQH method (2)
- Screening (2)
- Selbstorganisation (2)
- Sentinel-1 (2)
- Signaltransduktion (2)
- Simulation (2)
- Solution-state NMR (2)
- Stem cells (2)
- Supramolekulare Chemie (2)
- TNF receptor superfamily (2)
- TNF superfamily (2)
- TNFR1 (2)
- TRAIL (2)
- Tanzania (2)
- Telekommunikationsnetz (2)
- Thrombozyt (2)
- Top-Quark (2)
- VEGF (2)
- Vaskularisierung (2)
- Verhalten (2)
- Zellteilung (2)
- actin (2)
- adolescents (2)
- agriculture (2)
- allometric scaling (2)
- antibiotics (2)
- antibody (2)
- antibody fusion proteins (2)
- artemisinin (2)
- autophagy (2)
- bacteria (2)
- biofabrication (2)
- blood-brain barrier (2)
- body composition (2)
- body size (2)
- bone (2)
- bone adhesive (2)
- cAArC (2)
- calcium phosphate cement (2)
- cancer genomics (2)
- cancer immunotherapy (2)
- cancer metabolism (2)
- cardiomyopathy (2)
- carotid atherosclerosis (2)
- carotid stenosis (2)
- carotid ultrasound (2)
- caspase-8 (2)
- cell death (2)
- cell imaging (2)
- cell therapy (2)
- chemistry (2)
- complexes (2)
- copper (2)
- cystic fibrosis patients (2)
- dSTORM (2)
- degree of stenosis (2)
- dendritic cells (2)
- density functional calculations (2)
- diagnostic markers (2)
- diazepam (2)
- dopamine (2)
- drug delivery (2)
- ecology (2)
- endothelium (2)
- evolution (2)
- exciton-exciton (2)
- fatigue (2)
- fluorescence (2)
- genome annotation (2)
- genome assembly (2)
- geomorphology (2)
- glioblastoma multiforme (2)
- glucocorticoid receptor (2)
- glycoprotein VI (2)
- healthy volunteers (2)
- human behaviour (2)
- hydroboration (2)
- hydrogel (2)
- imaging (2)
- immunotherapy (2)
- information extraction (2)
- inhibitory neurotransmission (2)
- interleukin-8 (2)
- irradiation (2)
- knockout (2)
- lymphocytes (2)
- macrophages (2)
- magnetic properties and materials (2)
- measurement (2)
- megakaryopoiesis (2)
- melt electrospinning writing (2)
- meningitis (2)
- mental health (2)
- mesencephalic locomotor region (2)
- metabolic adaptation (2)
- microRNA (2)
- microtubules (2)
- mitochondria (2)
- molecular biology (2)
- mouse (2)
- multiple bonding (2)
- multiple sclerosis (2)
- natural language processing (2)
- neuroinflammation (2)
- neurology (2)
- neuroprotection (2)
- next generation sequencing (2)
- oncology (2)
- oncolytic virus (2)
- optimal drug combination (2)
- optogenetics (2)
- outcome (2)
- pathogens (2)
- performance (2)
- personalized medicine (2)
- photothrombotic stroke (2)
- platelet (2)
- polycyclic aromatic hydrocarbons (2)
- polymers (2)
- population pharmacokinetics (2)
- prognosis (2)
- prognostic marker (2)
- prostate cancer (2)
- quantum optics (2)
- radicals (2)
- reactive oxygen species (2)
- recurrence (2)
- relapse (2)
- rheumatoid arthritis (2)
- ring-expansion reaction (2)
- screening (2)
- secondary prevention (2)
- semiconductor lasers (2)
- smartphone app (2)
- social attention (2)
- software (2)
- structure (2)
- subthalamic nucleus (2)
- surgery (2)
- survival (2)
- synthesis (2)
- targeted therapy (2)
- tight junction (2)
- trade-offs (2)
- two-photon excited fluorescence (2)
- vascularization (2)
- wound healing (2)
- (classical and atypical) Werner syndrome (1)
- (hem)ITAM signaling (1)
- + (1)
- ++ (1)
- 1,2-additions (1)
- 18F-FDS (1)
- 2 Jets (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 25-hydroxycholesterol 7 alpha-hydroxylase (1)
- 2D material (1)
- 3-coordinate organoboron compounds (1)
- 3D Bioprinting (1)
- 3D Modell (1)
- 3D Point Cloud Processing (1)
- 3D Tumormodell (1)
- 3D cultures (1)
- 3D model (1)
- 3D remote sensing (1)
- 3D tumour model (1)
- 3D-Modell (1)
- 3 T (1)
- 4-HNE (1)
- 4D flow (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATOC (1)
- A-D-A dyes (1)
- A-priori-Wissen (1)
- A. abbreviatus (1)
- A. likoko (1)
- ABP1 (1)
- ADHD (1)
- AHRR (1)
- ALAN (1)
- AMP-activated kinases (1)
- AMP‐activated protein kinase (1)
- APOBEC3G (1)
- APRI (1)
- ARCI (1)
- ARCI EM type III (1)
- ATP generation (1)
- AUX1 (1)
- Abfallbehandlung (1)
- Abfallwirtschaft (1)
- Absorbed Doses (1)
- Abszision (1)
- Accurate (1)
- Acids (1)
- Acinetobacter baumannii (1)
- Ackerschmalwand (1)
- Actin (1)
- Actin-bindende Proteine (1)
- Activation (1)
- Active Galactic Nuclei (1)
- Active disease (1)
- Acute myeloid leukemia (AML) (1)
- AdS-CFT Correspondence (1)
- AdS-CFT-Korrespondenz (1)
- AdS/CFT correspondence (1)
- Adaptation (1)
- Adherens junction (1)
- Adhesion GPCR (1)
- Adipositas (1)
- Administered Activities (1)
- Adolescent (1)
- Adult (1)
- Advanced Analytics (1)
- Affekt (1)
- African Trypanosomiasis (1)
- Akt (1)
- Akt/PKB (1)
- Aktionsforschung (1)
- Alcohol dependence (1)
- Algorithm (1)
- Alien limb syndrome (1)
- Alkaloid (1)
- Allogeneic transplantation (1)
- Alpine habitats (1)
- Alzheimer's disease (1)
- Aminerge Nervenzelle (1)
- Amygdala (1)
- Anarchic limb syndrome (1)
- Andalusian varieties (1)
- Angiogenese (1)
- Angstverarbeitung (1)
- Animales Nervensystem (1)
- Anisotropic Magnetoresistance (1)
- Anomalous magnetic-moment (1)
- Anreize (1)
- Antarctica (1)
- Anthropocene (1)
- Anti-infective (1)
- Antibiotikum (1)
- Antigen CD19 (1)
- Antigen CD28 (1)
- Antigenrezeptor (1)
- Antikörper (1)
- Antimalariamittel (1)
- Antioxidants (1)
- Antizipation (1)
- Aortic arch (1)
- Apidae (1)
- Apis mellifera (1)
- Aplastic anemia (1)
- Apoptosis (1)
- Applied physics (1)
- Arabidopsis thaliana (1)
- Arbeitsmobilität (1)
- Archaeology (1)
- Aromatically annulated triquinacenes (1)
- Aromatisch anellierte Triquinacene (1)
- Arylborylene Complexes (1)
- Arzneimittel (1)
- Ascaris lumbricoides (1)
- Aspergillus (1)
- Aspergillus fumigalus (1)
- Assistenzbedarf (1)
- Associative learning (1)
- Astronomie (1)
- Astrophysical neutrino sources (1)
- Astroteilchenphysik (1)
- Atacama (1)
- Atmospheric muons (1)
- Atomic and molecular interactions with photons (1)
- Atrial fibrillation (1)
- Attitude Determination and Control (1)
- Attitude Dynamics (1)
- Audit Quality (1)
- Audit sampling (1)
- Aufsichtsrat (1)
- Autoaggressionskrankheit (1)
- Autologous hematopoietic stem cell transplantation (1)
- Autoproteolysis (1)
- Auxine (1)
- Außenhandel (1)
- B cell (1)
- B cell malignancies (1)
- B cells (1)
- B,N-heterocylcles (1)
- B-B bond activation (1)
- B7-H1 (1)
- BAL (1)
- BCG (1)
- BMI (1)
- BRAF mutation (1)
- BRAF-mutant (1)
- BRAF-mutiert (1)
- BRCA1 (1)
- BaBiO3 (1)
- Bank (1)
- Banking (1)
- Barrier (1)
- Behaviour (1)
- Behavioural ecology (1)
- Benchmarking (1)
- Benutzeroberfläche (1)
- Benzimidazole (1)
- Berberine (1)
- Berechnung (1)
- Berufsbildung (1)
- Bevacizumab (1)
- Bhabha Scattering (1)
- Big Data (1)
- Bildbearbeitung (1)
- Bildgebung intakten Knochens (1)
- Bildungswesen (1)
- Binge drinking (1)
- Biofabrication (1)
- Biofabrikation (1)
- Biofilm (1)
- Biofilmarchitektur (1)
- Bioink (1)
- Biokinetics (1)
- Biologika (1)
- Biomarke (1)
- Biomedicine (1)
- Biophysics (1)
- Bioreaktor (1)
- Biotinten (1)
- Bioverfügbarkeit (1)
- Bipolar disorder (1)
- Biradikal (1)
- Bistability (1)
- Black Holes in String Theory (1)
- Black holes (1)
- Black-hole (1)
- Blazar (1)
- Blood (1)
- Body schema (1)
- Boson (1)
- Bosons (1)
- Brain cancer (1)
- Brain diseases (1)
- Brain endothelial cells (1)
- Branching fractions (1)
- Bronchopulmonary dysplasia (1)
- Brustkrebs (1)
- Business Process Management (1)
- Business Process Modeling (1)
- By-Light Scattering (1)
- B−H activation (1)
- C-60 fullerene (1)
- C-C coupling (1)
- C-terminal HSP90 inhibitors (1)
- C/EBP (1)
- C3a (1)
- C3aR (1)
- C5a (1)
- C5aR1 (1)
- C5aR2 (1)
- C60 fullerene (1)
- CAR T cells (1)
- CCI (1)
- CD274 (1)
- CD4+ T cells (1)
- CD8+ T cells (1)
- CD95 (1)
- CDC42 (1)
- CERN (1)
- CIDP (1)
- CMV (1)
- CO sensing (1)
- CO‐releasing molecules (CORMs) (1)
- CRH1 (1)
- CRISPR-Cas systems (1)
- CRM (1)
- CRMO (1)
- CVID (1)
- CXCL5 (1)
- CXCL8 (1)
- CXCR2 (1)
- CYP1B1 (1)
- C\(_{60}\) fullerene (1)
- Cadherine (1)
- Caenorhabditis elegans (1)
- Calcium (1)
- Calciumphosphat (1)
- Calciumphosphate (1)
- Calciumphosphatzemente (1)
- Callyspongia siphonella (1)
- Cancer Cell (1)
- Cancer genetics (1)
- Candida (1)
- Capicua transcriptional repressor (1)
- Capillary Electrophoresis (1)
- Cardiac ventricles (1)
- Cardiovascular diseases (1)
- Cardiovascular risk factors (1)
- Cardiovascular risk prediction (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Carotisstenose (1)
- Caspase (1)
- Cataglyphis (1)
- Cdh13 (1)
- Cell migration (1)
- Cell stainin (1)
- Central Asia (1)
- Central nervous system (1)
- Ceramic polymer composite (1)
- Chambers (1)
- Channelrhodopsin-2 (1)
- Characterization and analytical techniques (1)
- Charge carrier recombination (1)
- Charge-transfer-Komplexe (1)
- Chelatbildner (1)
- Chemical Structure (1)
- Chemical composition (1)
- Chemical stability (1)
- Chemische Synthese (1)
- Cherenkov underwater neutrino telescope (1)
- Children (1)
- Chile (1)
- Chili RNA Aptamer (1)
- Chimeric Antigen Receptor (1)
- Chimärer Antigenrezeptor (1)
- China (1)
- Chiral spin liquids (1)
- Chirale Spinflússigkeiten (1)
- Choice Behavior/physiology (1)
- Chondrogenesis (1)
- Chromatographie (1)
- Chronische Nierenerkrankung (1)
- Chronobiology (1)
- Circinella (1)
- Circular dichroism (1)
- Click Chemie (1)
- Clinical Data Warehouse (1)
- Clinically silent stroke (1)
- CoQ10 (1)
- Code Examples (1)
- Codon (1)
- Cognitive behavior (1)
- Cognitive neuroscience (1)
- Coherent Multidimensional Spectroscopy (1)
- Community-acquired methicillin-resistant Staphylococcus aureus (1)
- Commuting (1)
- Complexity (1)
- Computational Chemistry (1)
- Computational and Systems Biology (1)
- Computed axial tomography (1)
- Computer modelling (1)
- Computersimulation (1)
- Conditioning regimen (1)
- Confidence intervals (1)
- Confocal microscopy (1)
- Conformal Metrics (1)
- Congolese Ancistrocladus plants (1)
- Conical Intersections (1)
- Conifers (1)
- Conservation (1)
- Consistent partial least squares (1)
- Construct Modeling (1)
- Controlling (1)
- Corporate Governance (1)
- Corporate Social Responsibility (1)
- Correlated Electron Materials (1)
- Correlated Fermions (1)
- Corticobasal syndrome (1)
- Corticosteroids (1)
- Cosmic-rays (1)
- Couplings (1)
- CpG (1)
- Cranial sutures (1)
- Cross-section (1)
- Curvature Equation (1)
- Cushing-Syndrom (1)
- Cushing’s disease (1)
- Cutaneous lymphoma (1)
- Cysteinproteasen (1)
- Cystic fibrosis (1)
- Cytochrome P 450 pathway (1)
- Cytokine (1)
- Cytologie (1)
- Cytosol (1)
- DC gate (1)
- DCAF17 (1)
- DEM (1)
- DFT mechanism (1)
- DLS and AFM measurements (1)
- DNA electronic transport (1)
- DNA methyltransferases (1)
- DNA repair (1)
- DNA sequencing (1)
- DNA weight (1)
- DNA-Schäden (1)
- DNA-repair (1)
- DNA-repair genes (1)
- DPP IV (1)
- DRG (1)
- DROSHA (1)
- DSB focus substructure (1)
- DSM (1)
- Dark-Matter (1)
- Dark-matter (1)
- Data Analytics (1)
- Data Warehouse (1)
- Data acquisition (1)
- Data-Warehouse-Konzept (1)
- Decision Support (1)
- Declarative Performance Engineering (1)
- Deep Inelastic-scattering (1)
- Delbruck Scattering (1)
- Demokratische Republik Kongo (1)
- Dendritic cell (1)
- Dendritische Zelle (1)
- Densovirus (1)
- Dental Phobia (1)
- Depression (1)
- Design (1)
- Development (1)
- Developmental biology (1)
- Dezellularisierung (1)
- Diabetes mellitus (1)
- Diagnosis prediction (1)
- Diagnostic Imaging Exams (1)
- Diagnostic medicine (1)
- Dickdarmtumor (1)
- Diffusion tensor imaging (1)
- Dihydroboranes (1)
- Disease severity (1)
- Dopamin (1)
- Dopamine (1)
- Dosimetry (1)
- Dosis (1)
- Dotierung (1)
- Double-Beta Decay (1)
- Doxorubicin (1)
- Drug delivery platforms (1)
- Drug discovery (1)
- Drug resistance (1)
- Drug testing (1)
- Dual setting system (1)
- Dynamical Systems (1)
- Dynamical system (1)
- Dynamics (1)
- Dünne Schicht (1)
- Dünnschichten (1)
- E(+)E(-) collicions (1)
- E-Learning (1)
- E2 conjugating enzyme (1)
- E3 ligating enzyme (1)
- E8 symmetry (1)
- EBF1 (1)
- EQ5D-5L (1)
- ER-Stress (1)
- ERK (1)
- ERK signaling (1)
- ERK1/2 (1)
- ESAT‐6‐like secretion system (1)
- ESKAPE (1)
- ESS (1)
- EUROASPIRE (1)
- EWAS (1)
- Earnings Management (1)
- Earnings Quality (1)
- Earnings management (1)
- Earth observation (1)
- Echinococcosis (1)
- Echinococcus (1)
- Efficiency (1)
- Efficiency Gains (1)
- Effizienzsteigerung (1)
- Efflux transport (1)
- Eierstockkrebs (1)
- Eigenvectors (1)
- Einkommensverteilung (1)
- Einwandige Kohlenstoff-Nanoröhre (1)
- Einzelmolekülmikroskopie (1)
- Elderly (1)
- Electrical impedance tomography (1)
- Electromagnetic signals (1)
- Electromagnon (1)
- Electron (1)
- Electrophysiology (1)
- Electrospinning (1)
- Electroweak Measurements (1)
- Electroweak Phase-Transition (1)
- Electroweak interaction (1)
- Elektrizitätsverbrauch (1)
- Elektromagnon (1)
- Elektron-Phonon-Wechselwirkung (1)
- Elektronentransfer (1)
- Elektrospinnen (1)
- Elissen-Palm flux (1)
- Embryonic induction (1)
- Embryos (1)
- Emergence (1)
- Emotionales Verhalten (1)
- Empirical Analysis (1)
- Enantiomerentrennung (1)
- Endogene Rhythmik (1)
- Endoplasmic-Reticulum Stress (1)
- Endothel (1)
- Energieeffizienz (1)
- Energy (1)
- Energy Efficiency (1)
- Enhancer elements (1)
- Entanglement (1)
- Entscheidungsunterstützung (1)
- Entscheidungsunterstützungssystem (1)
- Entwicklung (1)
- Entzündung (1)
- Environmental impact (1)
- Epidemiology (1)
- Epigenetic (1)
- Epigenetic regulation (1)
- Epitaxy (1)
- Epstein-Barr virus-induced gene 2 (1)
- Equipment (1)
- Erfolgsplanung (1)
- EsaA (1)
- Escherichia coli (1)
- European Organization for Nuclear Research. ATLAS Collaboration (1)
- European Society for Immunodeficiencies (ESID) (1)
- European Spanish (1)
- European group (1)
- Event builder (1)
- Events GW150914 (1)
- Evolutionary developmental biology (1)
- Evolutionary emergence (1)
- Excited state dynamics (1)
- Exciton (1)
- Exciton coupling (1)
- Exciton localization dynamics (1)
- Exercise testing (1)
- Experimental Studies (1)
- Experimentelle Psychologie (1)
- Expiry date (1)
- Explosives (1)
- Explosivstoff (1)
- Extensions of gauge sector (1)
- Extracellular matrix (1)
- Extracellular volume (1)
- Extramedullary disease (1)
- Extrazelluläre Matrix (1)
- Extreme flows (1)
- Exziton-Polariton (1)
- Exzitonenkopplung (1)
- Eye Movements/physiology (1)
- Eye development (1)
- FIB-4 (1)
- Face Voice Matching (1)
- Fahrerassistenzsystem (1)
- Fak regulation (1)
- Familial Beckwith-Wiedemann syndrome (1)
- Farbstoff (1)
- FasL (1)
- Fatigue (1)
- Fats (1)
- Fear Generalization (1)
- Fear Learning (1)
- Fear conditioning (1)
- Female (1)
- Fertigarzneimittel (1)
- Festkörperphysik (1)
- Fgf-signalling (1)
- Fibroblastenwachstumsfaktor (1)
- Finite support distributions (1)
- Flavor Violation (1)
- Fliegenkippen (1)
- Flowering plants (1)
- Flowers (1)
- Fludarabine (1)
- Fludarabine-treosulfan (FT) (1)
- Fluorescence spectroscopy (1)
- Fluoreszenzspektroskopie (1)
- Fluorine (1)
- Fluorverbindungen (1)
- Flüssigkristall (1)
- Forces (1)
- Forests (1)
- Fotochemie (1)
- Fotophysik (1)
- Fourier-Spektroskopie (1)
- Fractional cover analysis (1)
- Fractional quantum Hall effect (1)
- Fraktionaler Quanten-Hall-Effekt (1)
- Full body ownership illusion (1)
- Functional Connectivity (1)
- Funktionalisierung <Chemie> (1)
- Funktionalisierung von elektrogesponnenen Fasern (1)
- Funktionelle Konnektivität (1)
- Furchkonditionierung (1)
- Furcht (1)
- Furchtgeneralisierung (1)
- Fusarium (1)
- G Protein-coupled receptor (1)
- G-2 (1)
- G-Protein gekoppelte Rezeptor (1)
- G-quadruplex (1)
- GABAA (1)
- GAD1 (1)
- GRP78 (1)
- GSV (1)
- GVHD (1)
- Ga-68-labelled Peptides (1)
- Galactic sources (1)
- Gallensalze (1)
- Gas chromatography (1)
- Gaseous detectors (1)
- Gauge bosons (1)
- Gauge-gravity correspondence (1)
- Gauge/Gravity Duality (1)
- Gaussian approximation (1)
- Gelatine (1)
- Gen-Umwelt Interaktion (1)
- Gene by Environment (1)
- Gene expression analysis (1)
- Gene silencing (1)
- General anaesthesia (1)
- Generalisierung (1)
- Generalisierung <Kartografie> (1)
- Generation (1)
- Genetik (1)
- Genmutation (1)
- Genom (1)
- Genome (1)
- Genome Annotation (1)
- Genomics (1)
- Genotype (1)
- Geriatric care (1)
- Geriatrics (1)
- German PID-NET registry (1)
- Germany (1)
- Germline (1)
- Gesicht (1)
- Gestational diabetes (1)
- Gestationsdiabetes (1)
- Getz Ice Shelf (1)
- Gitterdynamik (1)
- Gliazelle (1)
- Glioblastoma (1)
- Glutathione (1)
- Glycidol (1)
- Glycoengineering (1)
- Glykane (1)
- Glykosylierung (1)
- Go/NoGo task (1)
- Google Earth Engine (1)
- Governance (1)
- Graft versus host disease (1)
- Gram-positive bacteria (1)
- Graph (1)
- Gravitons (1)
- Greenland ice sheet (1)
- Grenzfläche (1)
- Grenzflächenleitfähigkeit (1)
- Group B Streptococcus (1)
- Grundlagenforschung (1)
- Gruppo-italiano (1)
- GvHD (1)
- Gyrasehemmer (1)
- H-infinity (1)
- HARPES (1)
- HCV (1)
- HDAC (1)
- HEMA (1)
- HIV-associated candidiasis (1)
- HNE (1)
- HNSCC (1)
- HPA axis (1)
- HPLC (1)
- HRQOL (1)
- Hadron-Hadron scattering (experiments) (1)
- Hadron-hadron interactions (1)
- Haemophilus influenzae (1)
- Hard X-ray Angle Resolved Photoemission (1)
- Haut (1)
- Health (1)
- Heart (1)
- Heart failure (1)
- Helicasen (1)
- Hematopoietic Stem (1)
- Hematopoietic cell transplant (1)
- Heme-regulated inhibitor (1)
- Hemipelvectomy (1)
- Herzmuskelzelle (1)
- Heterosolarzelle (1)
- Heterostruktur (1)
- Hfq (1)
- Higgy-Boson (1)
- High grade glioma (1)
- High-Energies (1)
- High-Z Oxides (1)
- High-energy astrophysics (1)
- Hindbrain (1)
- Hippo pathway (1)
- Hippocampus (1)
- Histone deacetylase (1)
- Hochauflösende Fluoreszenzmikroskopie (1)
- Hodgkin lymphoma (1)
- Holstein model (1)
- Holstein-Modell (1)
- Honey bees (1)
- Hordeum vulgare (1)
- Hormontransport (1)
- Host Genome Integrity (1)
- Host-parasite interaction (1)
- Human Body Weight (1)
- Human Herpesvirus 6 (1)
- Human Muse Cells (1)
- Human behaviour (1)
- Human-Computer Interaction (1)
- Humanes Herpesvirus 6 (1)
- Humangenetik (1)
- Humans (1)
- Hunsrueck (1)
- Hurwitz theorem (1)
- Hyaluronic Acid (1)
- Hyaluronsäure (1)
- Hybrid Dynamical Systems (1)
- Hybridsystem (1)
- Hydrocarbon radicals (1)
- Hydrocarbons (1)
- Hydrogen (1)
- Hyperosmotic Stress (1)
- Hypothalamus (1)
- Hypothetical gauge bosons (1)
- Hypoxia (1)
- Hypoxie (1)
- IFN (1)
- IL-10 (1)
- IP3 (1)
- Icecube (1)
- Ideomotor Theory (1)
- Ideomotorik (1)
- IgG substitution therapy (1)
- Image Processing (1)
- Imatinib (1)
- Immune system (1)
- Immune-related adverse event (1)
- Immunologe (1)
- Immunology (1)
- Immunoprecipitation (1)
- Immuntherapie (1)
- Imo Bundesstaat (1)
- Imo State - Nigeria (1)
- Impella (1)
- Implicit and explicit reward learning (1)
- InSAR (1)
- InSAR height (1)
- Incontinentia pigmenti (1)
- Individualität (1)
- Induced apoptosis (1)
- Inducible Clindamycin Resistance (1)
- Induzierte pluripotente Stammzelle (1)
- Infectious disease (1)
- Inflammatio (1)
- Inflammatory Pain (1)
- Inflammatory diseases (1)
- Inflammatory pain (1)
- Information (1)
- Information Extraction (1)
- Information System (1)
- Information seeking and sharing (1)
- Information system (1)
- Informationsverarbeitung (1)
- Inhibition (1)
- Innovation (1)
- Input-Output-Tabelle (1)
- Insect flight (1)
- Insulin (1)
- Insulin-like Growth Factor I (1)
- Insulin-like growth factor-I (1)
- Integrine (1)
- Intention (1)
- Intentional Nonaction (1)
- Intentionale Nichthandlung (1)
- Interaction Design (1)
- Interactions (1)
- Interconnection (1)
- Interface Conductivity (1)
- Interfaces (1)
- Intergenerational income mobility (1)
- Intergenerationenmobilität (1)
- Intergenerative Einkommensmobilität (1)
- Interleukin-10 (1)
- Interleukin-6 (1)
- Invasion (1)
- Inverse Gaschromatographie (1)
- Invertebrate herbivory (1)
- Ionenkanal (1)
- Ionenleitfähigkeit (1)
- Ionic Liquid (1)
- Ionische Flüssigkeit (1)
- Ipilimumab (1)
- Iridate (1)
- Ischemic stroke (1)
- Isocyanate (1)
- Isolation (1)
- J-Aggregate (1)
- JAK2 (1)
- K-RAS (1)
- KIF (1)
- KIF11 (1)
- KM3NeT (1)
- KTaO3 (1)
- Kapillarelektrophorese (1)
- Kilombero (1)
- Kinect (1)
- Kinetic Self-assembly (1)
- Kleinsatellit (1)
- Klinisches Experiment (1)
- Knee (1)
- Knochenimplantat (1)
- Knochenkleber (1)
- Knochenregeneration (1)
- Knochenwachs (1)
- Knorpelbildung (1)
- Kohärente Multidimensionale Spektroskopie (1)
- Kokristallisation (1)
- Kollektive Invasion (1)
- Komplexität (1)
- Komponentenanalyse (1)
- Konditionierung (1)
- Konfidenzintervall (1)
- Konfokale Mikroskopie (1)
- Konforme Metrik (1)
- Kongo (1)
- Konische Durchschneidung (1)
- Korrelierte Fermionen (1)
- Krebs (1)
- Krebs <Medizin> (1)
- Kreditgenossenschaft (1)
- Kristallfeld (1)
- Körpergewicht (1)
- L1 reading comprehension (1)
- L2 reading comprehension (1)
- L2 reading motivation (1)
- LATE DEATHS (1)
- LC-HRESIMS (1)
- LC3-associated phagocytosis (1)
- LCD Pulse Shaper (1)
- LCD Pulsformer (1)
- LHC (1)
- LMICS (1)
- LSD1 (1)
- LST (1)
- La gestion des déchets (1)
- LaAlO3/SrTiO3 (1)
- Ladungstrennung (1)
- Ladungsträger (1)
- Ladungsträgerlokalisation (1)
- Lageregelung (1)
- Land Change Modeler (1)
- Landnutzungskartierung (1)
- Landsat time series (1)
- Lantana camara (1)
- Lanthantitanate (1)
- Laparoscopy (1)
- Large Hadron Collider (1)
- Laser Pulse Shaping (1)
- Laserpulsformung (1)
- Late mortality (1)
- Latin America (1)
- Latrophilin (1)
- Leaf traits (1)
- Learning and memory (1)
- Learning walk (1)
- Learning/physiology (1)
- Lebende Polymerisation (1)
- Lee Smolin (1)
- Leptonic (1)
- Lernen (1)
- Lernverhalten (1)
- Leseverstehen (1)
- Lewis-base adducts (1)
- Library Screening (1)
- Lichtabsorption (1)
- Lichtblattmikroskopie (1)
- Lichtheimia (1)
- Lichtscheibenmikroskopie (1)
- Lichtstreuung (1)
- Lidschlag (1)
- Lifetime spectroscopy (1)
- Ligand <Biochemie> (1)
- Light sheet microscopy (1)
- Limb development (1)
- Limb salvage (1)
- Limestone (1)
- Liquid Crystal (1)
- Liquid Crystals (1)
- Living Polymerisation (1)
- Llullaillaco Volcano (1)
- Lokalisation (1)
- Low energy electron microscopy LEEM (1)
- Low risk alcohol use (1)
- Low-income Countries (1)
- Lung (1)
- Lung disease, (1)
- Lunge (1)
- Lyapunov Stability (1)
- Lymph nodes (1)
- Lysine-specific methylase (1)
- Löslichkeit (1)
- M14 carboxypeptidasses (1)
- MASS (1)
- MCP1 (1)
- MDSC (1)
- MGMT promoter methylation (1)
- MI-RADS (1)
- MIBG (1)
- MMB (1)
- MMB complex (1)
- MODIS (1)
- MOF (1)
- MOLLI (1)
- MRI (1)
- MRI spectroscopy (1)
- MRSA (1)
- Maculinea butterfly (1)
- Magnesiumphosphate (1)
- Magnetic Resonance Imaging (1)
- Magnetic resonance imaging (1)
- Magnetische Eigenschaft (1)
- Magnetismus (1)
- Magnetit (1)
- Magnetometry (1)
- Magnetoresistance (1)
- Magnetowiderstand (1)
- Magnon (1)
- Makrokolonie (1)
- Male (1)
- Mamma carcinoma (1)
- Mammakarzinom (1)
- Management (1)
- Managementinformationssystem (1)
- Manganese Carbonyl ligands (1)
- Mangansilicide (1)
- Manöverintention (1)
- Masern-Virus (1)
- Masticatory mucosa (1)
- Mastoid process (1)
- Mathematik (1)
- Matter (1)
- Mc4r (1)
- Measles virus (1)
- Measurement error correlation (1)
- Measurement-based Analysis (1)
- Meat (1)
- Mechanisms (1)
- Mechanisms of Social Attention (1)
- Mechanismus (1)
- Mechanosensation (1)
- Media Psychology (1)
- Medical research (1)
- Medienkonsum (1)
- Megakaryopoese (1)
- Megakaryozytopoese (1)
- Melanom (1)
- Melt Electrowriting (1)
- Memory B cells (1)
- Meniskus (1)
- Meniskusimplantat (1)
- Mensch-Maschine-Kommunikation (1)
- Merger-specific Efficiency Gains (1)
- Mergers (1)
- Mergers and Acquisitions (1)
- Merkel cell carcinoma (MCC) (1)
- Merocyanine dyes (1)
- Mesenchymal stem/stromal cells (1)
- Messenger-RNAs (1)
- Messung (1)
- Metadynamik (1)
- Metal clusters (1)
- Metall-Isolator-Phasenumwandlung (1)
- Metallorganisches Netzwerk (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methodology (1)
- Metrics (1)
- Metrologie (1)
- Mfn2 KO mice (1)
- Microbiology and Infectious Disease (1)
- Midollo-Osseo (1)
- Migration (1)
- Mikroskopie (1)
- Mikrotubulus (1)
- Minimal change disease (1)
- Minimally invasive surgery (1)
- Missing Energy (1)
- Mitochondria (1)
- MnSi (1)
- Mobile genetic element (1)
- Model specification (1)
- Model-based Performance Prediction (1)
- Modell (1)
- Modifikation von Biokeramiken (1)
- Modular Hamiltonian (1)
- Modularer Hamiltonoperator (1)
- Molekulardynamik (1)
- Molekularstrahlepitaxie (1)
- Molekülsystem (1)
- Monoschicht (1)
- Monte Carlo simulation (1)
- Monte-Carlo-Simulation (1)
- Moral Hazard (1)
- Motivation (1)
- Motor behaviour (1)
- Mott Transistion (1)
- Mott-Isolator (1)
- Mott-Übergang (1)
- Mouse (1)
- Movement behavior (1)
- Mucor (1)
- Mucorales (1)
- Multi-Messenger (1)
- Multiferroics (1)
- Multiferroika (1)
- Multiphotonenmikroskopie (1)
- Multiple (1)
- Multiple myeloma (1)
- Multiple-Scattering (1)
- Multiplex PCR (1)
- Multiwavelength Astronomy (1)
- Muon spectrometers (1)
- Muscle function (1)
- Muscle power (1)
- Muster (1)
- Mutation (1)
- Myb-MuvB (1)
- Myrmecology (1)
- Myrmica ant non-equilibrium dynamics (1)
- N-heterocyclic olefins (1)
- N-terminal HSP90 inhibitors (1)
- NAFLD (1)
- NASH (1)
- NCH93 (1)
- NCI-H295R (1)
- NCO-sP(EO-stat-PO) (1)
- NF-Kappa-B (1)
- NF-κB/NFAT reporter cells (1)
- NFATc1 (1)
- NFκB (1)
- NHCs (1)
- NH\(_{3}\) (1)
- NIPAL4 (1)
- NIQs (1)
- NIR OLED (1)
- NLO Computations (1)
- NMR spectroscopy (1)
- NMR-Spektroskopie (1)
- NPY (1)
- Nachhaltigkeit (1)
- Nahfeldoptik (1)
- Nahrungserwerb (1)
- Nanoparticles (1)
- Nanostruktur (1)
- Naphthylisoquinoline (1)
- Naphthylisoquinoline alkaloids (1)
- Nasal Carriage (1)
- Necrotizing enterocolitis (1)
- Nectin‐2 (1)
- Neisseria gonorrhoeae (1)
- Neolithic period (1)
- Nephroblastom (1)
- Nephrogenese (1)
- Netherlands (1)
- Netzwerk (1)
- Neural Differentiation (1)
- Neural circuits (1)
- Neuroanatomie (1)
- Neurodevelopmental Disorder (1)
- Neuroimaging (1)
- Neuroinflammation (1)
- Neuroscience (1)
- Neutrino Detectors and Telescopes (experiments) (1)
- Neutrino Mass (1)
- Neutrinos (1)
- Nfatc1 (1)
- Nicht-kleinzelliges Bronchialkarzinom (1)
- Nigeria (1)
- Nivolumab (1)
- Nociceptor (1)
- Non-coding RNA (1)
- Non-smooth optimal control (1)
- Nonlinear Dynamics (1)
- Non‐ischaemic cardiogenic shock (1)
- Nuclear Medicine (1)
- Nucleus subthalamicus (1)
- Numerical Cognition (1)
- Nursing homes (1)
- OSCC (1)
- OSI (1)
- Oberflächenfunktionalisierung (1)
- Oberflächenphonon (1)
- Oberflächenphysik (1)
- Oberflächenplasmon (1)
- Object recognition (1)
- Oculomotor Muscles/physiology (1)
- Oncology (1)
- Operations Management (1)
- Optical spectroscopy (1)
- Optik (1)
- Optimal foraging (1)
- Optimale Kontrolle (1)
- Optogenetics (1)
- Oral anticoagulation (1)
- Ordered metal adsorbates on semiconductor surfaces (1)
- Ordinal Categorical Indictators (1)
- Organic and hybrid semiconductors (1)
- Organische Chemie (1)
- Oscillation (1)
- Outer membrane proteins (1)
- Overstatement models (1)
- OxPL (1)
- Oxide Heterostructure (1)
- Oxidized Phospholipids (1)
- Oxidized phospholipids (1)
- P(P) over-bar collisions (1)
- P-glycoprotein (1)
- P-gp (1)
- PA-flexed view (1)
- PALS (1)
- PCR (1)
- PD-1 (1)
- PD-L1 (1)
- PDF neurons (1)
- PET/CT (1)
- PID prevalence (1)
- PKD1 (1)
- PP collisions (1)
- PRKACA (1)
- PROMISE (1)
- PSMA (1)
- PSMA-RADS (1)
- PTEN (1)
- Parametric inference (1)
- Parkinson’s disease (1)
- Partial Least Squares Path Modeling (1)
- Particle accelerators (1)
- Particle tracking detectors (Gaseous detectors) (1)
- Particle-acceleration (1)
- Parvovirus (1)
- Paternal age and BMI effects (1)
- Pathogenesis (1)
- Pathogens (1)
- Patterns and drivers of invertebrate herbivory (1)
- Patterns and drivers of species diversity of phytophagous beetles (1)
- Patterns and drivers of species richness and community biomass of large mammals (1)
- Pavlovian-to-instrumental transfer (1)
- Pediatric Nuclear Medicine (1)
- Pediatric Patients (1)
- Peierls-Übergang (1)
- Pendeln (1)
- Pentixafor (1)
- Perception (1)
- Perowskit (1)
- Personalized medicine (1)
- Perturbative/Functional Renormalization Group (1)
- Perturbative/Funktionale Renormierungsgruppe (1)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (1)
- Perylenbisimide (1)
- Perylenbisimides (1)
- Perylene Bisimide (1)
- Perylene Bisimides (1)
- Pfadintegral (1)
- Pflanzen (1)
- Pflanzenhormone (1)
- Phagozytose (1)
- Pharmakokinetik (1)
- Pharmakotherapie (1)
- Phase- (1)
- Phenols (1)
- Phobie (1)
- Phosphatasen (1)
- Phosphoglykolat-Phosphatase (1)
- Phosphoglykolatphosphatase (1)
- Phospholipide (1)
- Phosphorylation (1)
- Photic (1)
- Photoelectron Spectroscopy (1)
- Photoelektronenspektroskopie (1)
- Photoemission electron microscopy PEEM (1)
- Photoluminescence (1)
- Photolumineszenz (1)
- Photoreceptor (1)
- Physical activity (1)
- Physiologie (1)
- Phytochemical investigations of a Congolese Ancistrocladus Liana (1)
- Phytochemie (1)
- Pigmentdispergierender Faktor (1)
- Plant signalling (1)
- Plants (1)
- Plasmaantrieb (1)
- Plasmamembranorganisation (1)
- Plasmon (1)
- Platzierungsalgorithmen (1)
- Poly(2-oxazolin)e (1)
- Polyethylenglykole (1)
- Polygonum cuspidatum (1)
- Polymer-drug interaction (1)
- Polymere (1)
- Polymers (1)
- Polynomial Factor Models (1)
- Polyphenole (1)
- Polysaccharide (1)
- Poplars (1)
- Positron annihilation spectroscopy (1)
- Positron-Emission Tomography (1)
- Postoperative complications (1)
- Preconcentration (1)
- Predictive Analytics (1)
- Prefrontal cortex (1)
- Premna (1)
- Prescriptive Analytics (1)
- Preterm birth (1)
- Prevalence (1)
- Prior information (1)
- Privatsphäre (1)
- ProQ (1)
- Probability theory (1)
- Prognostic markers (1)
- Prognostic scoring system (1)
- Prospektives Gedächtnis (1)
- Protease-sensitive release (1)
- Protein (1)
- Protein Kinase D (1)
- Protein Kinase D 1 (1)
- Protein folding (1)
- Protein kinase D3 (PKD3) (1)
- Proteinkinase A (1)
- Proteinkinase D (1)
- Proteomics Analysis of Complexes (1)
- Proteotype (1)
- Proteus vulgaris (1)
- Proton-Proton Collisions (1)
- Präsenz (1)
- Präzisionsmessung (1)
- Psychiatric disorders (1)
- Psychiatrie (1)
- Psychologie (1)
- Psychology (1)
- Psychometrie (1)
- Psychomotor Performance/physiology (1)
- Pulmonary function tests (1)
- Pulsed laser deposition (1)
- Punktwolke (1)
- Quality assessment of antimalarial medicines from the Congo (1)
- Quality ccontrol (1)
- Quality-control (1)
- Qualität der Abschlussprüfung (1)
- Qualität der Rechnungslegung (1)
- Qualitätskontrolle (1)
- Quanten-Hall-Effekt (1)
- Quanten-Monte-Carlo (1)
- Quanteninformation (1)
- Quantenpunkt (1)
- Quantifizierung (1)
- Quantitative Mikroskopie (1)
- Quantum Hall effect (1)
- Quantum electrodynamics (1)
- Quinolone amides (1)
- R package (1)
- RADS (1)
- RAS Evaluation (1)
- RCT (1)
- REDD1 (1)
- RFID (1)
- RNA Sequencing (1)
- RNA expression (1)
- RNA metabolism (1)
- RNA protein interactions (1)
- RNA secondary structures (1)
- RNA sequencing (1)
- RNA-Seq (1)
- RNA-seq transcriptome (1)
- RNAi (1)
- RNAlater (1)
- RNS (1)
- ROR1 (1)
- ROS (1)
- RSV-A ON1 (1)
- RT-qPCR (1)
- Radiation (1)
- Radiation Protection (1)
- Radiation exposure (1)
- Radiation-associated Cancer Risk (1)
- Radiographs (1)
- Radiotherapy (1)
- Raphe (1)
- RapidEye (1)
- Raumwahrnehmung (1)
- Regelbasiertes Modell (1)
- Regimes (1)
- Regional trade (1)
- Regionaler Arbeitsmarkt (1)
- Regionaler Handel (1)
- Regionalpolitik (1)
- Regionalwirtschaft (1)
- Regulierung (1)
- Reiz (1)
- Relativistic heavy-ion collisions (1)
- Reminder e-mails (1)
- Remnant RX J1713.7-3946 (1)
- Remote Sensing (1)
- Reporter Cells (1)
- Reporterzellen (1)
- Rescue behaviour (1)
- Research Article (1)
- Respiratory tract infection (1)
- Retinopathy (1)
- Rhizomucor (1)
- Rhizopus (1)
- RhoA (1)
- Rhodopsin (1)
- Ribozyme-catalyzed RNA labeling (1)
- Ringöffnungspolymerisation (1)
- Risk (1)
- Risk Assessment (1)
- Roboter (1)
- Robotics (1)
- Runge-type Theorems (1)
- Ruthenium (1)
- Ruxolitinib (1)
- Röntgenastronomie (1)
- Röntgendiffraktometrie (1)
- S. aureus (1)
- SASHA (1)
- SB332235 (1)
- SIX1 (1)
- SPOT-6 (1)
- SR/mitochondria metabolic feedback (1)
- SREBP (1)
- SSR42 (1)
- SSTR (1)
- SSTR-RADS (1)
- ST 772 (1)
- ST18 (1)
- SWAT (1)
- SWAT model (1)
- Saccades/physiology (1)
- Salmo trutta fario (1)
- Satellit (1)
- Scarabaeidae (1)
- Scattering (1)
- Scenario analysis (1)
- Scheme for solving optimal control problems (1)
- Schlichte Funktion (1)
- Schmerzforschung (1)
- Schmerztherapie (1)
- Secondary stroke prevention (1)
- Sediment (1)
- Segmentation (1)
- Sekundärprävention (1)
- Selbstassemblierung (1)
- Self-assembly (1)
- Self-navigation (1)
- Self-renewal (1)
- Semantics (1)
- Semantik (1)
- Sense of Agency (1)
- Sensor Fusion (1)
- Sentinel-2 (1)
- Septine (1)
- Sequential quadratic Hamiltonian scheme (1)
- Serine proteases (1)
- Server (1)
- Sex chromosome (1)
- Sex determination (1)
- Sexual development and function (1)
- ShMOLLI (1)
- Shelf-life (1)
- Shell (1)
- Sibling donor (MSD) (1)
- Silver (1)
- Single Molecule Localization Microscopy (SMLM) (1)
- Single-Photon (1)
- Situationsbewusstsein (1)
- Skin (1)
- Skull (1)
- Small RNA (1)
- Small interfering RNAs (1)
- Small-Gain Theorem (1)
- Smoking (1)
- Social Cognition (1)
- Social Cueing (1)
- Social Web (1)
- Societe Francaise (1)
- Soft tissues (1)
- Software (1)
- Software Defined Networking (1)
- Software Performance Engineering (1)
- Software-defined Networking (1)
- Softwarisierte Netze (1)
- Solid tumors (1)
- Somites (1)
- Soziale Aufmerksamkeit (1)
- Soziale Mobilität (1)
- Soziale Software (1)
- Spatial Cognition (1)
- Spatially resolved 2D spectroscopy (1)
- Species delimitation (1)
- Species richness (1)
- Specific Phobia (1)
- Specimen grinding (1)
- Speckle tracking (1)
- Spezifische Phobien (1)
- Spezifische Wärme (1)
- Sphingosine-1-phosphate (1)
- Sphingosine-1-phosphats (1)
- Spin flip (1)
- Spin-Bahn-Kopplung (1)
- Spin-Orbit interaction (1)
- Spin-Phonon Kopplung (1)
- Spin-chemistry (1)
- Spin-phonon coupling (1)
- Spinflüssigkeit (1)
- Stability (1)
- Stabilität (1)
- Stammzelle (1)
- Standardmodell <Elementarteilchenphysik> (1)
- Staphylococcus (1)
- Staphylococcus aureus USA300 (1)
- Starke Kopplung (1)
- Stechameisen (1)
- Stem cell (1)
- Stem-cell biotechnology (1)
- Stenosis degree (1)
- Stenosis length (1)
- Stereochemistry (1)
- Sternpolymere (1)
- Stigmatisierung (1)
- Stimme (1)
- Stimmverarbeitung (1)
- Stimulation (1)
- Stoffwechsel (1)
- Stokes-shifted fluorescence emission (1)
- Strains (1)
- Strange Baryon Production (1)
- Strategisches Management (1)
- Stratigraphy (1)
- Streptococcus agalactiae (1)
- Stroke (1)
- Stroke unit (1)
- Stromal cells (1)
- Strontiumtitanat (1)
- Strontiumvanadate (1)
- Structural Equation Modeling (1)
- Structural elucidation (1)
- Structural equation modelling (1)
- Structure elucidation (1)
- Struktur-Aktivitäts-Beziehung (1)
- Strukturgleichungsmodell (1)
- Sub-Saharan Africa (1)
- Subject (1)
- Subtercola vilae (1)
- Success Factors (1)
- Supernova (1)
- Support vector machine (1)
- Supportive therapy (1)
- Supramolecular Block Copolymers (1)
- Supramolecular aggregates (1)
- Supramolekulare Aggregate (1)
- Supramolekulare Struktur (1)
- Surface Plasmon (1)
- Surface Raman spectroscopy (1)
- Surgical and invasive medical procedures (1)
- Surgical oncology (1)
- Survey (1)
- Suspensionskultur (1)
- Swine (1)
- Syap1 knockout (1)
- Symmetry (1)
- Systemic sclerosis (1)
- T cell (1)
- T cell receptor (1)
- T cell suppression (1)
- T cells (1)
- T-cell lymphoma (1)
- T1 mapping (1)
- TDDFT (1)
- TDMT (1)
- TEV (1)
- TFP (1)
- TGFβ/BMP signaling (1)
- TLR2 (1)
- TLR3 (1)
- TLR4 (1)
- TMEM16F (1)
- TNF (1)
- TNF-alpha (1)
- TNFR family costimulatory receptors (1)
- TNFR2 (1)
- TNFR2 agonists (1)
- TNFR2 antagonism (1)
- TNFα (1)
- TNNI3 (1)
- TP53 (1)
- TPCA1 (1)
- TRAF1 (1)
- TRAF2 (1)
- TRAILR1 (1)
- TRAILR2 (1)
- TRPA1 channel (1)
- TWEAK (1)
- Tagesrhythmus (1)
- Tamoxifen (1)
- TanDEM-X (1)
- Tc-99m-MAG3 Scans (1)
- TeV energies (1)
- Telemedizin (1)
- Temozolomide (1)
- Terramechanics (1)
- Theoretische Chemie (1)
- Therapeutisches System (1)
- Therapie (1)
- Therapiesimulation (1)
- Thermodynamik (1)
- Thin Films (1)
- Thin intermetallic films (1)
- Thiotepa-busulfan-fludarabine (TBF) (1)
- Thrombo-inflammation (1)
- Thrombosis (1)
- Thrombozytopenie (1)
- Thrust Vector Control (1)
- Tiermodell (1)
- Time resolved measurements (1)
- Time-resolved photoemission electron microscopy (1)
- Time-resolved photoluminescence (1)
- Tissue engineering (1)
- Toddler (1)
- Top quark (1)
- Topological insulators (1)
- Topologische Isolatoren (1)
- Topologischer Isolator (1)
- Torque (1)
- Total Factor Productivity (1)
- Tourenplanung (1)
- Tractography (1)
- Transcription (1)
- Transcription factor NRF1 (1)
- Transcriptomic (1)
- Translation (1)
- Translation Initiation (1)
- Translational research (1)
- Transplantat-Wirt-Reaktion (1)
- Transposable element (1)
- Transverse-Momentum (1)
- Trees (1)
- Tregs (regulatory T cells) (1)
- Triquinacenderivate (1)
- Triticeae (1)
- Triticum aestivum (1)
- Trousseau's syndrome (1)
- Trypanosomiase (1)
- Tryptophan hydroxylase (1)
- Tubulin (1)
- Tumor (1)
- Tumorzelle (1)
- Twin Domains (1)
- Twin Suppression (1)
- Two-color pump-probe spectroscopy (1)
- U-Net (1)
- USA (1)
- UV-VIS-Spektroskopie (1)
- UV/Vis spectroscopy (1)
- UV–Vis (1)
- Ultrakurzzeitspektroskopie (1)
- Ultrarelativistic Heavy-Ion (1)
- Ultrashort echo time - UTE (1)
- Umwelt (1)
- Unconventional/Topological superconductivity (1)
- Universal Functions (1)
- Unkonventionelle/Topologische Supraleitung (1)
- Unnötige Warnung (1)
- Unrelated donor (UD) (1)
- Unternehmensverfassung (1)
- User Behavior (1)
- User-Guidelines (1)
- Ustilago maydis (1)
- V-ATPase (1)
- VLBW (1)
- VMAT (1)
- Vakuole (1)
- Valentine Leukocidin Genes (1)
- Valgus osteoarthritis (1)
- Value at Risk (1)
- Vascularized (1)
- Vaskularisation (1)
- Vcsels (1)
- Verarbeitende Industrie (1)
- Verbundwerkstoff (1)
- Verkehrspsychologie (1)
- View (1)
- Virtuelle Realität (1)
- Visuelle Aufmerksamkeit (1)
- Visuo-tactile congruency (1)
- Voice Processing (1)
- W & Z bosons (1)
- W-Boson (1)
- WSS (1)
- Wahrscheinlichkeitstheorie (1)
- Warnung (1)
- Waste management (1)
- Weak-Interactions (1)
- WebGIS (1)
- Wechselwirkungen (1)
- Wheel (1)
- White matter lesions (1)
- Wide-gap-Halbleiter (1)
- Wilms tumor (1)
- Wilms-Tumor (1)
- Winkelaufgelöste Photoemission mit harten Röntgenstrahlen (1)
- Wire chambers (MWPC, Thin-gap chambers, drift chambers, drift tubes, proportional chambers etc) (1)
- Wirkstoff (1)
- Wirkstofftestung (1)
- Wirtschaftliche Integration (1)
- Wirtschaftsinformatik (1)
- Woodhouse-Sakati Syndrom (1)
- Woodhouse-Sakati sydrome (1)
- Wundheilung (1)
- X-ray radiography (1)
- XRD (1)
- YAP (1)
- Yoga (1)
- Young Adult (1)
- ZF1 degradation assay (1)
- ZFAND1 (1)
- Zahnbehandlungsphobie (1)
- Zebrafish (1)
- Zell Migration (1)
- Zelloberfläche (1)
- Zentralasien (1)
- Zinc (1)
- Zinkselenid (1)
- ZnO-NP (1)
- Zusammenstoß (1)
- Zwillingsbildung (1)
- [68Ga]Pentixafor (1)
- \(^{177}\)Lu-OPS201 (1)
- abdominal surgery (1)
- absolute bioavailability (1)
- accessory medulla (1)
- accidents (1)
- accumulation (1)
- accuracy (1)
- acetate (1)
- acid ceramidase (1)
- acid ceramidase inhibitor ceranib-2 (1)
- acoustic radiation force impulse imaging (1)
- acrophobia (1)
- actin cytoskeleton (1)
- actin-binding proteins (1)
- action control (1)
- activated delayes flourescence (1)
- activation (1)
- active galactic nuclei (1)
- active ingredients (1)
- acute kidney injury (1)
- acute lymphoblastic leukemia (1)
- adalimumab (1)
- adaptive choice-based conjoint (1)
- additive manufacturing (1)
- adenoma (1)
- adenotonsillectromy (1)
- adipocyte (1)
- adipose (1)
- adiposity (1)
- administrative boundary (1)
- adrenal gland (1)
- adrenocortical carcinoma (1)
- adult attention deficit/hyperactivity disorder (adult ADHD) (1)
- advanced breast cancer (1)
- aerobic fitness (1)
- affect bursts (1)
- age at onset (1)
- age groups (1)
- age-related macular degeneration (1)
- agroecology (1)
- airway management (1)
- alcohol use disorder (1)
- alkaloids-Quinoid (1)
- alkynes (1)
- alternative splicing (1)
- altitudinal gradients (1)
- alveolar epithelium (1)
- amine borane dehydrocoupling (1)
- aminergic neurons (1)
- amodiaquine (1)
- amorphous solid dispersion (1)
- amphiphilic block copolymer (1)
- amsacrine (1)
- amyloidoma (1)
- amyotrophic lateral sclerosis (1)
- amyotrophic lateral sclerosis (ALS) (1)
- anakinra (1)
- analysis of variance (1)
- animal behaviour (1)
- animal physiology (1)
- animal research (1)
- anime (1)
- anomaly detection (1)
- anorexia nervosa (1)
- anti-contactin-1 (1)
- anti-depressant drug (1)
- antibacterial (1)
- antibacterial activity (1)
- antibiofilm (1)
- antibiotic (1)
- antibiotic resistance (1)
- anticancer (1)
- anticipation (1)
- antifungal (1)
- antifungal susceptibility (1)
- antimicrobial compounds (1)
- antimicrobial susceptibility (1)
- antitrypanosomal (1)
- anti‐aging (1)
- anxiety (1)
- anxiety generalization (1)
- anxiolytics (1)
- aortocaval fistula model (1)
- appraisal theory of emotion expression (1)
- arctic greening (1)
- arenes (1)
- artemether - lumefantrine (1)
- arterial thrombus formation (1)
- artifacts (1)
- artificial intelligence (1)
- artificial light at night (1)
- aspergillosis (1)
- asylum seekers (1)
- asylum status (1)
- atmospheric waves (1)
- atrial fibrillation (1)
- attention (1)
- auto-planning (1)
- autoantibody (1)
- autobiography (1)
- autoimmune disease (1)
- autoimmune encephalitis (1)
- autonomic nervous system (1)
- autosomal recessive (1)
- auxin (1)
- axillary dissection (1)
- back reaction (1)
- bacterial pathogen (1)
- bacterial physiology (1)
- bacteriology (1)
- baghdadite (1)
- balancing trade-offs (1)
- bank mergers (1)
- bariatric surgery (1)
- behavior (1)
- behavioral plasticity (1)
- beige adipocytes (1)
- bench press (1)
- bending strength (1)
- benige tumor (1)
- beta-lactam antibiotics (1)
- biceps tendinitis (1)
- biceps tendon (1)
- big earth data (1)
- bilateral internal carotid artery stenosis (1)
- binary species (1)
- bioavailability (1)
- bioceramics (1)
- biofabricated vascular graft (1)
- biofilm architecture (1)
- bioinformatics (1)
- bioinformatics tool (1)
- bioink (1)
- bioinks (1)
- biokinetics (1)
- biological rhythm (1)
- biological scaffolds (1)
- biological techniques (1)
- biologics (1)
- biomarker (1)
- biomarker signature (1)
- biomaterial ink (1)
- biomaterials (1)
- biomaterials – cells (1)
- biomechanics (1)
- biomolecular processes (1)
- biophysics (1)
- bioreactor (1)
- biotechnology (1)
- biotic interaction (1)
- bispecific antobodies (1)
- bisulfite pyrosequencing (1)
- black trout syndrome (1)
- bladder (1)
- blazars (1)
- bleeding (1)
- blinatumoman (1)
- blinking (1)
- blocking phagocytosis (1)
- blood (1)
- blood brain barrier (1)
- blood cerebrospinal fluid barrier (1)
- blood-cerebrospinal fluid barrier (1)
- bohrbar (1)
- bone critical size defect (1)
- bone graft substitutes (1)
- bone marrow stromal cells (1)
- bone metastases (1)
- bone microenvironment (1)
- bone tissue engineering (1)
- bone wax (1)
- boolean modeling (1)
- boreholes (1)
- borohydrides (1)
- boronate (1)
- boronic acid (1)
- borylenes (1)
- bottom-up processing (1)
- brain (1)
- brain activity (1)
- brain development (1)
- brain disorders (1)
- brain endothelial cell (1)
- brain endothelial cells (1)
- brain networks (1)
- brain plasticity (1)
- brain tumor (1)
- breast cancer (1)
- bridge-to-transplant (1)
- bronchoalveolar lavage fluid (1)
- bronchopulmonary dysplasia (1)
- broth microdilution (1)
- brown trout (1)
- building (1)
- bullae (1)
- burn severity (1)
- burnt-wood (1)
- calcium (1)
- calcium phosphate (1)
- calnexin (1)
- calving front (1)
- cancer imaging (1)
- capillary zone electrophoresis (1)
- carabid beetles (1)
- carbenes (1)
- carbon (1)
- carbon monoxide (1)
- cardiac autonomic nervous system (1)
- cardiac metabolism (1)
- cardiac remodelling (1)
- cardiac surgery (1)
- cardiac tissue (1)
- cardiolipin (1)
- cardiomyocytes (1)
- cardiopulmonary bypass (1)
- cardiovascular genetics (1)
- cardiovascular risk factors (1)
- care (1)
- cartilage repair (1)
- catalysis (1)
- catchment (1)
- catheterization (1)
- catheters (1)
- cattle (1)
- caveolin-1 (Cav-1) (1)
- cefotiam (1)
- cell biology (1)
- cell death and immune response (1)
- cell death in the nervous system (1)
- cell differentiation (1)
- cell growth (1)
- cell migration (1)
- cell signalling (1)
- cell therapy and immunotherapy (1)
- cellular model (1)
- cellular neuroscience (1)
- ceramide (1)
- cerebral microbleeds (1)
- cerebrospinal fluid (1)
- cervical dystonia (1)
- channelrhodopsins (1)
- chaperones (1)
- charge carrier localization (1)
- charge recombination (1)
- charge separation (1)
- chemical crosslinking (1)
- chemical engineering (1)
- chemokine (1)
- chemokine receptor (1)
- child behavior (1)
- chimeric antigen receptor (1)
- chirality (1)
- chirality-induced spin selectivity (1)
- chlamydia (1)
- chlorophyll fluorescence imaging (1)
- cholesterol (1)
- cholesterol 25 hydroxylase (1)
- cholesteryl ester (1)
- chondrocyte (1)
- chondrogenesis (1)
- chronic kidney disease (1)
- chronic kidney disease (CKD) (1)
- chronic non-bacterial osteomyelitis (1)
- circRNA (1)
- circadian clock (1)
- circadian rhythm (1)
- circadian rhythms (1)
- circular transcriptome sequencing (1)
- cisplatin (1)
- claudin-5 (1)
- click chemistry (1)
- climate extremes (1)
- clinical characteristics (1)
- clinical imaging (1)
- clinical outcome (1)
- clinical pharmacy (1)
- clinical trial (1)
- closed-loop systems (1)
- cluster analysis (1)
- co-culture (1)
- coagulation system (1)
- coastline (1)
- cocrystal (1)
- cognitive control (1)
- coherence (1)
- coherent risk measures (1)
- cold adaptation (1)
- collagen (1)
- collagen sponge (1)
- collective invasion (1)
- collimator (1)
- collodion baby (1)
- collybistin (1)
- colonization (1)
- commission error (1)
- common diseases (1)
- comparative genomics (1)
- comparison (1)
- competition (1)
- complement deposition (1)
- complement factor H (1)
- complex DNA damage (1)
- composite material (1)
- composition (1)
- computational science (1)
- computer-mediated communication (1)
- computerized tomography (1)
- concealed information test (1)
- conditioning (1)
- congruency sequences (1)
- conjugation (1)
- consensus (1)
- conservation (1)
- constructed trade-offs (1)
- context-based teaching (1)
- contextual fear conditioning (1)
- continuous theta burst stimulation (cTBS) (1)
- continuum limit (1)
- control levels (1)
- convolutional neural network (1)
- copeptin (1)
- coping (1)
- copy number variation (1)
- coronary heart disease (1)
- correspondence (1)
- cortical excitability (1)
- cortical silent period (1)
- cortisol (1)
- cosmology (1)
- count time series (1)
- covalent and site-specific RNA labeling (1)
- cristal engeneering (1)
- crop statistics (1)
- cross-coupling (1)
- cross-sectional study (1)
- cryosphere (1)
- cryostructured scaffolds (1)
- crystal growth (1)
- crystallization (1)
- crystallography (1)
- curcumin (1)
- curvature (1)
- curved hydrocarbons (1)
- cuticular permeability (1)
- cyclase-associated protein (1)
- cyclase-associated protein 2 (1)
- cyclic compounds (1)
- cyclophosphamide (FLAMSA) (1)
- cytokinesis (1)
- cytoskeleton (1)
- cytotoxic (1)
- daratumumab (1)
- data structure (1)
- data warehouse (1)
- dead-wood enrichment (1)
- decay (1)
- decellularization (1)
- deception (1)
- deep learning (1)
- default-interventionist framework (1)
- definition (1)
- dehydrocoupling (1)
- dehydrogenaticve borylation (1)
- democracy (1)
- democracy profiles (1)
- dendritic cell (1)
- denosumab (1)
- depth dose curves (1)
- designer cell (1)
- desk-based (1)
- desmin (1)
- desmin-related myopathy (1)
- desminopathy (1)
- desmoglein (1)
- desmoplastic small round cell tumor (1)
- desmosome (1)
- detrended fluctuation analysis (1)
- deubiquitinases (1)
- developmental forms (1)
- dexamethasone (1)
- diabetes (1)
- diacylglycerol (1)
- diacylglycerol (DAG) (1)
- dialysis adequacy (1)
- diazadiborinines (1)
- diborane(6) (1)
- diboranes (1)
- diboration (1)
- diborene (1)
- diborenes (1)
- diborynes (1)
- differentiation (1)
- differentiation potential (1)
- diffuse large B-cell lymphoma (1)
- diffusion weighted mri (1)
- digital health (1)
- diluted magnetic Semiconductor (1)
- dimeric peptide (1)
- direct muss spectrometric profiling (1)
- discrete systems (1)
- disease genetics (1)
- disease modelling (1)
- dissolution rates (1)
- distractor-response binding (1)
- distributed control (1)
- distributed learning (1)
- distributions (1)
- diversity gradients (1)
- document analysis (1)
- domain-specific language (1)
- donor (1)
- donor-acceptor systems (1)
- dorsal root ganglion (1)
- dose individualization (1)
- dosimetry (1)
- double arc (1)
- doxorubicin (1)
- drillable (1)
- drivers and patterns of diversity and herbivory (1)
- driving simulation (1)
- drought (1)
- drug release (1)
- drug resistance evolution (1)
- dual abbindend (1)
- dual setting (1)
- dual setting system (1)
- dualsteric (1)
- duchenne muscular dystrophy (1)
- duplication-deficiency (1)
- dyads (1)
- dyes (1)
- dynamic facial emotion expression (1)
- dystonia (1)
- e(+)e(-) Collisions (1)
- e-learning (1)
- early brain injury (1)
- early-life stress (1)
- earlywood (1)
- eccentric hypertrophy (1)
- echocardiography (1)
- ecosystem service (1)
- ecosystem services (1)
- education system (1)
- effective point of measurement (1)
- efficient intervention points (1)
- eindimensionale Systeme (1)
- electrical resistivity tomography (1)
- electrochemistry (1)
- electron-precise diborates (1)
- electronic properties and materials (1)
- electrospun fibers (1)
- elementary body (1)
- eletrhydrodynamic (1)
- elite (1)
- emergency care (1)
- emission (1)
- emotion (1)
- emotion enactment (1)
- emotion processing (1)
- emotion recognition (1)
- emotional behavior (1)
- emotions (1)
- emulsions oil-in-water (1)
- en bloc transfer (1)
- enantiomers (1)
- enbrel (1)
- end-stage renal disease (1)
- endocytosis (1)
- endothelial cells (1)
- endothelin-1 (1)
- endurance (1)
- endurance exercise (1)
- endurance training (1)
- enercy-richness hypothesis (1)
- energy homeostasis (1)
- enhancer (1)
- environmental justice (1)
- environmental sciences (1)
- environmental sustainability (1)
- enzyme mechanism (1)
- enzymes (1)
- epidemiology (1)
- epidural block (1)
- epithelial (1)
- epithelial-mesenchymal transition (1)
- epithelial-to-mesenchymal transition (1)
- error estimation (1)
- estimation error (1)
- etanercept (1)
- ethics (1)
- eugenol (1)
- evapotranspiration (1)
- event-related potentials (1)
- evolutionary ecology (1)
- evolutionary genetics (1)
- exciton (1)
- exciton dynamics (1)
- exciton-polariton (1)
- exercise intervention (1)
- expansion microscopy (1)
- expected value of control (1)
- external stimuli (1)
- extinction (1)
- extinction dynamics (1)
- extracellular domain (1)
- extramedullary hematopoiesis (1)
- extreme phenotypes (1)
- eye movement (1)
- eye movements (1)
- eye-tracking (1)
- fMRI (1)
- fMRT (1)
- face (1)
- face-voice integration (1)
- faces (1)
- fan culture (1)
- fault detection (1)
- fear (1)
- fear conditioning (1)
- fear learning (1)
- febrile seizures (1)
- feminist rap (1)
- femoral head (1)
- fertility (1)
- fibre length (1)
- fibroblast (1)
- fibromyalgia (1)
- fibrotest (1)
- field-induced surface hopping (1)
- fission (1)
- flash freezing (1)
- fliegende Toilette (1)
- flora (1)
- flourescence quantum yield (1)
- flu-like symptoms (1)
- fluconazole (1)
- fluerescence (1)
- fluidics (1)
- fluorenscence (1)
- fluorescence microscopy (1)
- fluorescent probes (1)
- fluorine (1)
- fluoroarene (1)
- fluorogen-activating RNA aptamer (FLAP) (1)
- fluoroquinolone (1)
- fluxosome (1)
- fly-tipping (1)
- flying toilet (1)
- folda-dimer (1)
- follistatin 288 (FST288) (1)
- follistatin 315 (FST315) (1)
- food colorings (1)
- food resources (1)
- foraging patterns (1)
- forensic sample (1)
- forest ecology (1)
- forest fire (1)
- forest management (1)
- forest resources inventory (1)
- formation control (1)
- fractional variability (1)
- fracture (1)
- fragmentation functions (1)
- free choice (1)
- free movement (1)
- free radical polymerization (1)
- friut fly behaviour (1)
- full arc (1)
- fully convolutional neural networks (1)
- function (1)
- functional MRI (1)
- functional analysis (1)
- functional connectivity (1)
- functional training (1)
- fungal ecology (1)
- fungal evolution (1)
- fungal molecular diagnostics (1)
- fungal rhodopsins (1)
- funktionale Präpolymere (1)
- games (1)
- gangliosides and lipid rafts (1)
- gastric-bypass surgery (1)
- gastrointestinal cancer (1)
- gastrointestinal tract (1)
- gauge/gravity duality (1)
- gaze control (1)
- gekrümmte Kohlenwasserstoffe (1)
- gem-bisboronates (1)
- gene alleles (1)
- gene expression analysis (1)
- gene family evolution (1)
- gene network (1)
- gene regulation (1)
- gene regulation in immune cells (1)
- genetic codon expansion (1)
- genetic counselling (1)
- genetic engineering (1)
- genetic recombination (1)
- genetics of the nervous system (1)
- genome (1)
- genome analysis (1)
- genome-wide association studies (1)
- genomic imprinting (1)
- genomics (1)
- genotoxicity (1)
- glacier front (1)
- glacier terminus (1)
- glia cells (1)
- glioblastoma multiforme (GBM) (1)
- glioma (1)
- global (1)
- global change (1)
- glucose transporter (1)
- glycine transporter 2 (1)
- glycoprotein Ibα (1)
- glyvine uptake (1)
- graft vs. host disease (1)
- graft-versus host (1)
- graft-versus-host-disease (1)
- granules (1)
- gravitational waves (1)
- green fluorescence protein (GFP) (1)
- ground penetrating radar (1)
- ground-dwelling predators (1)
- growth (1)
- growth patterns (1)
- growth ring width (1)
- guanylyl cyclase (GC) (1)
- guided bone regeneration (1)
- guideline adherent treatment (1)
- guidelines (1)
- gustatory dysfunction (1)
- gut–liver axis (1)
- hA<sub>3</sub>AR (1)
- habit (1)
- habit strength (1)
- hadronic Recoil (1)
- hadronischer Rückstoß (1)
- haematopoietic stem cell (1)
- halogens (1)
- hard x-ray photoemission (1)
- head and neck squamous cell carcinoma (1)
- heart rate variability (1)
- heart-to-mediastinum ratio (1)
- heat wave (1)
- helical molecules (1)
- helicenes (1)
- hematopoietic stem cell transplantation (1)
- heme oxygenase-1 (1)
- hemicraniectomy (1)
- hemodiafiltration (1)
- hemodialysis (1)
- hemophagocytosis (1)
- hemorrhagic (1)
- hemostasis (1)
- henoch-schönlein purpura (1)
- hepatitis B virus (1)
- hereditary breast and ovarian cancer (1)
- heterocycles (1)
- heterotypic scaffold design (1)
- heuristics (1)
- hiPSC aggregation (1)
- high LET irradiation (1)
- high efficiency (1)
- high risk (1)
- high-intensity training (1)
- high-performance sports (1)
- high-resolution tandem mass spectrometry (1)
- hip fracture (1)
- hippocampus (1)
- histogenesis (1)
- histological subtype (1)
- histone H2AX (1)
- historical document analysis (1)
- historical printings (1)
- homogeneous catalysis (1)
- homogenization (1)
- honeybee (1)
- honeybees (1)
- hospital exemption (1)
- hospital-acquired methicillin-resistant Staphylococcus aureus (1)
- human adipose-derived stromal cells (1)
- human cerebral endothelial cells (1)
- human plasma (1)
- human xenografted mouse models (1)
- hybrid fabrication (1)
- hybrid materials (1)
- hydrogels (1)
- hydrological regime (1)
- hydroxyapatite (1)
- hydroxylation (1)
- hyperosmolality (1)
- hyperpersonal communication (1)
- hypertension (1)
- hypothermia (1)
- hypoxia (1)
- iGC (1)
- iPSC (1)
- ichthyology (1)
- ichthyosis (1)
- identification (1)
- iliac crest (1)
- illness-death model (1)
- image processing (1)
- imaging PAM (1)
- imiquimod (1)
- immediate-early gene (1)
- immune evasion (1)
- immunity (1)
- immunocompetent skin (1)
- immunotherapy of cancer (1)
- implant (1)
- impurity profiling (1)
- in situ microscopy (1)
- in vitro model (1)
- in vitro models (1)
- in vitro selection from a structured RNA library (1)
- incentive salience (1)
- incidence (1)
- individual response (1)
- individualization (1)
- indole-3-acetic acid (1)
- indolylpyrimidylpiperazines (1)
- induced pluripotent stem cells (1)
- infection biology (1)
- infections (1)
- infectious diseases (1)
- inflammatory gene (1)
- inflation (1)
- information retrieval (1)
- information sharing (1)
- inherited cardiomyopathies (1)
- inherited macrothrombocytopenia (1)
- inhibition (1)
- inhibitor (1)
- injectable in situ gelling slow release system (1)
- injection site reactions (1)
- injury (1)
- inmates (1)
- innate immune evasions (1)
- insect abundance (1)
- insect collection (1)
- insurance medicine (1)
- intact bone imaging (1)
- integrative management strategy (1)
- integrin α2 (1)
- integrins (1)
- interactions (1)
- intercomparison (1)
- interface (1)
- interface conductivity (1)
- interferon beta (1)
- interleukin (1)
- interleukin-6 (1)
- intermediate dose Ara-C (1)
- intermediate filaments (1)
- intermittent exercise (1)
- intermolecular applications of ribozymes (1)
- internal carotid artery stenosis (1)
- intersession experiences (1)
- intersession processes (1)
- interval training (1)
- intervention point analyzing (1)
- intestine (1)
- intracellular bacterial pathogens (1)
- intracerebral hemorrhage (1)
- intracranial bleeding (1)
- invasive aspergillosis (1)
- inventory (1)
- iodine (1)
- ionization chambers (1)
- ionization energy (1)
- ionization potential (1)
- iron metabolism (1)
- ischemia reperfusion injury (1)
- ischemia time (1)
- isotropic hyper fine coupling (1)
- jet shapes (1)
- jet stream (1)
- jets (1)
- keratinocytes (1)
- key structure - fluorescence activation relationships (SFARs) (1)
- kidney (1)
- kidney development (1)
- kinesin (1)
- kinesthesia (1)
- kolorektales Karzinom (1)
- koronare Herzerkrankung (1)
- la durabilité environnementale (1)
- labour market (1)
- lactate threshold training (1)
- lag effect (1)
- land sharing (1)
- land surface (1)
- land use (1)
- land-cover area (1)
- language development (1)
- language in media (1)
- language intervention (1)
- late onset sepsis (1)
- late positive potential (1)
- lateral process of the talus (1)
- latewood (1)
- lattice forces (1)
- leaf width (1)
- learner characteristics (1)
- learning (1)
- les toilettes volantes (1)
- library screening (1)
- lichen planus (1)
- lifestyle (1)
- ligand binding (1)
- ligand exchange (1)
- ligand-receptor promiscuity (1)
- light-emitting-diodes (1)
- light-matter interaction (1)
- lightsheet microscopy (1)
- lignan (1)
- lineage-specific genes (1)
- linear conversion (1)
- linguistic cues (1)
- linguistic politics (1)
- lipid metabolism (1)
- liponeurocytoma (1)
- liquid biopsy (1)
- liver (1)
- liver disease (1)
- liver metastases (1)
- local field potentials (1)
- localization microscopy (1)
- logical trade-offs (1)
- long head of biceps tendon (1)
- long-term potentiation (1)
- loss of function (1)
- low-cost photometer (1)
- low-valent compounds (1)
- low-valent main group chemistry (1)
- low-valent main-group species (1)
- lowland beech forests (1)
- luminescence (1)
- lung cancer (1)
- lung metastases (1)
- lying (1)
- lymph nodes (1)
- lymphohistiocytosis (1)
- lymphoid tissues (1)
- lyso-phospholipids (1)
- mAb engineering (1)
- mRNA (1)
- mTOR (1)
- macrocolony (1)
- macroecology (1)
- macrophage polarization (1)
- magnesium phosphate cement (1)
- magnetic field effect (1)
- maintenance therapy (1)
- major river basins (1)
- management (1)
- manga (1)
- manoeuvre intention (1)
- match load (1)
- materials for optics (1)
- maternal separation (1)
- mating (1)
- mating preference (1)
- mebendazole (1)
- mechanical performance (1)
- mechanisms of disease (1)
- mechanistic modelling (1)
- medaka (1)
- medical rehabilitation (1)
- medication extraction (1)
- medicinal plant (1)
- medicine (1)
- medieval manuscripts (1)
- medulloblastoma (1)
- megakaryocyte (1)
- melatonin (1)
- melt electrowriting (MEW) (1)
- membrane active (1)
- memory (1)
- meningioma (1)
- meningococcal disease (1)
- meningococcus (1)
- meniscus implant (1)
- merkel cell polyomavirus (MCPyV) (1)
- merocyanines (1)
- mesenchymal stem cell (1)
- mesenchymal stem cells (1)
- mesenchymal stromal cell (1)
- mesentery (1)
- meta-analysis (1)
- metabolic flux (1)
- metabolic modeling (1)
- metabolic modelling (1)
- metabolic switch (1)
- metabolism (1)
- metabolism of infected and uninfected host cells (1)
- metabolite profiling (1)
- metabolomic (1)
- metabolomic profiling (1)
- metacognition (1)
- metal complexenes (1)
- metallo-supramolecular polymer (1)
- metals (1)
- metaproteomics (1)
- metastasis (1)
- metastasis-associated in colon cancer 1 (MACC1) (1)
- methods (1)
- methylation array (1)
- methylprednisolone (1)
- miR-221-5p (1)
- micelles (1)
- micro processor complex (1)
- micro-chambers (1)
- micro-optics (1)
- microbial rhodopsins (1)
- microbial surface component recognising adhesive matrix molecules (1)
- microbiology (1)
- microbiota (1)
- microfilament (1)
- microfluidics (1)
- midbody remnant (1)
- migrant (1)
- minerals (1)
- minimal residual disease (1)
- minipig (1)
- minocycline (1)
- mitochondrial genome (1)
- mitochondrial mRyR1 (1)
- mitofusin 2 (1)
- mitosis (1)
- mitotic gene expression (1)
- mitotic genes (1)
- mixed methods (1)
- mobile app (1)
- mobile health intervention (1)
- model-based diagnosis (1)
- molecular imaging (1)
- molecular neuroscience (1)
- molecular signature (1)
- molecular structures (1)
- molecular subtypes (1)
- monitoring (1)
- monocyte-derived DC (1)
- monotoring (1)
- moonlighting (1)
- morphing (1)
- motility (1)
- motor aging (1)
- motor-evoked potentials (MEP) (1)
- mouse feeding model (1)
- movement (1)
- mucormycosis (1)
- multi-photon microscopy (1)
- multi-spectral (1)
- multiphoton microscopy (1)
- multiresistance (1)
- multivariate analysis (1)
- murine (1)
- muscarinic receptors (1)
- mutants (1)
- mycophenolic acid (1)
- myelination (1)
- myeloid-derived suppressor cell (MDSC) (1)
- n-Halbleiter (1)
- n-type semiconductors (1)
- nalmefene (1)
- nano-satellite (1)
- nanocomplex (1)
- nanoparticles (1)
- nanophotonics and plasmonics (1)
- nanoscale devices (1)
- naphthylisoquinoline alkaloids (1)
- nasal mucosal barrier function (1)
- native populations (1)
- natural pest control (1)
- naturalistic scenes (1)
- naïve B cells (1)
- near-IR chromophores (1)
- necroptosis (1)
- need for assistance (1)
- negation detection (1)
- neonatal outcome (1)
- neonates (1)
- nerve injury (1)
- nervous system (1)
- nest microbiota (1)
- neume notation (1)
- neural circuits (1)
- neurocytoma (1)
- neurodegenerative disease (1)
- neuroendocrine neoplasia (1)
- neuroendocrine neoplasms (1)
- neuroendocrine tumors (1)
- neuromuscular disease (1)
- neuronal (1)
- neuronal apoptosis (1)
- neurooncology (1)
- neuropathic pain (1)
- neuropeptide (1)
- neurotrophic factors (1)
- neurovascular unit (1)
- neutral sphingomyelinase-2 (1)
- neutrinos (1)
- neutrophil (1)
- next-generation sequencing (1)
- next-generation-sequencing (1)
- niche (1)
- nicknames (1)
- non-alcoholic fatty liver disease (NAFLD) (1)
- non-alcoholic steatohepatitis (NASH) (1)
- non-invasive fibrosis assessment (1)
- non-smooth optimization (1)
- nonalcoholic fatty liver disease (1)
- noncoding RNA (1)
- nonconvex optimization (1)
- noncovalent complex (1)
- noncovalent nanocomplex (1)
- normal distribution (1)
- nu SVR (1)
- nuclear envelope (1)
- nuclear export (1)
- null-aggregate (1)
- number of (1)
- obesity (1)
- object segmentation (1)
- obsessive-compulsive (1)
- obstructive sleep apnoea (1)
- office environment (1)
- office-workers (1)
- olfactory dysfunction (1)
- olfactory testing (1)
- oligodendrocyte (1)
- oncogenes (1)
- oncolysis (1)
- oncolytic vaccinia virus (1)
- one-dimensional systems (1)
- online dating (1)
- online survey (1)
- ontology (1)
- open waste burning (1)
- optical antenna (1)
- optical character recognition (1)
- optical materials and structures (1)
- optical music recognition (1)
- optimal drug targeting (1)
- optimal pharmacological modulation (1)
- optimal treatment strategies (1)
- optimization (1)
- organic solar cells (1)
- origin (1)
- orthoreovirus (1)
- orthostatic test (1)
- oscillations (1)
- osteochondral defect (1)
- osteogenesis (1)
- otakuism (1)
- outcome devaluation (1)
- outcomes research (1)
- ovarian cancer (1)
- overreaching (1)
- overuse injury (1)
- oxidative DNA damage (1)
- oxidative stress (1)
- oxide heterostructure (1)
- oxidische Heterostruktur (1)
- oxindole alkaloids (1)
- oxygen vacancies (1)
- p-block element (1)
- p21-activated kinase Mbt/PAK4 (1)
- paediatrics (1)
- pain generator (1)
- panel sequencing (1)
- panic disorder (1)
- panniculitis (1)
- paranodopathy (1)
- parasexual recombination (1)
- parasite biology (1)
- parent-child relationship (1)
- parental perception (1)
- partial agonists (1)
- partial arc (1)
- passive transfer (1)
- patch-clamp (1)
- pathogenesis (1)
- pathogenic bacteria (1)
- patient preference (1)
- patient-based evidence (1)
- patient-reported outcomes (1)
- peatland (1)
- pediatrics (1)
- peer review (1)
- pefloxacin (1)
- peginterferon bet-1a (1)
- pemphigus (1)
- penetration bias (1)
- penumbra (1)
- peptide inhibitor design (1)
- peptidomoics (1)
- performativity (1)
- pericytes (1)
- permeability (1)
- persistence (1)
- person identity processing (1)
- personality development (1)
- personality judgments (1)
- perylene bisimide (1)
- perylene bisimide dimers (1)
- perylene bisimides (1)
- pesicicles (1)
- pharmacokinetics (1)
- pharmacophore map (1)
- phase transitions and critical phenomena (1)
- phenolic compounds (1)
- phenotypic screening (1)
- phosphorescence (1)
- phosphorescene spectra (1)
- phosphorylation (1)
- photoconductive interlayer (1)
- photodynamic chemotherapy (1)
- photoelectron spectroscopy (1)
- photoluminescence spectroscopy (1)
- photolysis (1)
- photonic devices (1)
- photophysical prosperties (1)
- photophysics (1)
- physical activity (1)
- physical activity promotion (1)
- physical saliency (1)
- phytic acid (1)
- pi-conjugation (1)
- piRNA (1)
- piscine orthoreovirus (1)
- pit membrane diameter (1)
- pkd (1)
- placebo and nocebo effects (1)
- plan comparison (1)
- plant reproduction (1)
- plant-derived metabolites (1)
- plants (1)
- plant–microbe–pollinator triangle (1)
- plant–pathogen interaction (1)
- plaque cross-sectional area (1)
- plasma membrane (1)
- plasma membrane depolarization (1)
- plasma membrane organization (1)
- plasminogen (1)
- platelet degranulation (1)
- platelet-neutrophil complexes (PNCs) (1)
- podosome formation (1)
- point shear wave elastography (1)
- pointing task (1)
- pol(2-oxazoline) (1)
- polarimetery (1)
- polarization (1)
- pollination (1)
- pollination network (1)
- poly(2-oxazine) (1)
- poly(2-oxazoline) (1)
- poly(2-oxazoline)s (1)
- poly(glycidol) (1)
- polycaprolactone (1)
- polyglycerol sulfates (1)
- polynomials (1)
- polyphenols (1)
- population genetics (1)
- position estimation (1)
- positron (1)
- positron annihilation lifetime spectroscopy (1)
- post-fire management (1)
- post-translational modification (1)
- posttranscriptional control (1)
- powerlifting (1)
- pre-B (1)
- precision medicine (1)
- predictive markers (1)
- predictive performance (1)
- premature aging (1)
- premixed (1)
- preschool (1)
- presynaptic hyperekplexia (1)
- preterm infants (1)
- primary endpoint (1)
- primary healthcare (1)
- primary immunodeficiency (PID) (1)
- primary outcome (1)
- primary vascular smooth muscle‐like cells (vSMCs) (1)
- pro-B (1)
- probe-based real-time PCR (1)
- procedural learning (1)
- production machines (1)
- proliferation (1)
- proliferative darkening syndrome (1)
- prospective memory (1)
- prostate-specific membrane antigen (1)
- protected forests (1)
- protein binding (1)
- protein kinase D1 (1)
- protein processing (1)
- protein transport (1)
- protein-bound uremic toxins (1)
- protein-protein interaction (PPI) (1)
- proteins (1)
- proteomics (1)
- präfabriziert (1)
- psoriasis (1)
- psychological pain modulation (1)
- psychology (1)
- psychometrics (1)
- psychosocial adaptation (1)
- psychosocial stress (1)
- psychotherapy (1)
- puberty (1)
- pyrolysis (1)
- quality assurance (1)
- quality of democracy (1)
- quality of life (QoL) (1)
- quantile forecasts (1)
- quantitative analysis (1)
- quantum Monte Carlo (1)
- quantum dot (1)
- quantum dots (1)
- quantum gravity (1)
- quantum information (1)
- qubits (1)
- questionnaires (1)
- radiation (1)
- radiation sensitivity (1)
- radical (1)
- radical ion pair (1)
- radiopacity (1)
- radiotherapy (1)
- ray (1)
- reaction times (1)
- reactive intermediates (1)
- real life setting (1)
- real world evidence (1)
- reciprocal translocation (1)
- recombinant tissue-type plasminogen activator (1)
- reconstructive surgery (1)
- recording methods (1)
- recovery (1)
- rectum (1)
- refractory aGvHD (1)
- regenerative medicine (1)
- registry for primary immunodeficiency (1)
- regulatory T cells (1)
- regulatory T cells (Treg) (1)
- regulatory capital (1)
- regulatory dendritic cells (1)
- reinforcement learning (1)
- reliability (1)
- renal imaging (1)
- repeated sprint (1)
- reprogamming of host cell metabolism (1)
- required hydrophilic–lipophilic balance (1)
- rereading (1)
- resettlement refugees (1)
- resistance (1)
- resistance training (1)
- resonance theory (1)
- response inhibition (1)
- restriction factors (1)
- restrictive cardiomyopathy (1)
- resveratrol biosynthesis (1)
- retention interval (1)
- reticulate body (1)
- retinal pigment epithelium (1)
- retrospective (1)
- review (1)
- rhBMP–2 (1)
- rheumatic diseases (1)
- rheumatology (1)
- rhodomyrtone (1)
- ring-expansion reactions (1)
- ring-opening polymerization (1)
- ripk1 (1)
- ripk3 (1)
- risk society (1)
- risk stratification (1)
- robust control (1)
- rulebased analysis (1)
- ruthenium (1)
- sPEG (1)
- saccades (1)
- sacha inchi oil (1)
- sample storage (1)
- saproxylic organisms (1)
- sarcomere (1)
- satellite formation flying (1)
- satellite remote sensing (1)
- scaffold (1)
- search (1)
- seco-NIQs-Naphthylisoindolinone (1)
- secreted effectors (1)
- segmental progeria (1)
- self-determination theory (1)
- semantic segmentation (1)
- semileptonic & radiative decays (1)
- sensor data (1)
- sensor supports (1)
- sentinel (1)
- sentinel prey (1)
- sepsis (1)
- sequence analysis (1)
- sequential addition (1)
- serial reaction time task (1)
- serotonin (1)
- serotonin deficiency (1)
- setting reaction (1)
- sex robots (1)
- shared reading (1)
- short neuropeptide F (1)
- short-range JCT-coupling (1)
- short-range order (1)
- shoulder (1)
- shoulder pain (1)
- shyness (1)
- sigma boranes (1)
- signal specification (1)
- signal transduction (1)
- signalling (1)
- silica supraparticles (1)
- simple (1)
- simulation and modeling (1)
- simulation training (1)
- simultaneous presentation paradigm (1)
- single arc (1)
- single cell anatomy (1)
- single photon (1)
- single-molecule tracking (1)
- sirolimus (1)
- site-specific protein modification (1)
- situation awareness (1)
- skeletal progenitor cells (1)
- skeletal-related events (1)
- skewness (1)
- skin model (1)
- sleep (1)
- slope bogs (1)
- small RNA (1)
- small RNAs (1)
- small intestinal submucosa scaffold (1)
- small-cell lung cancer (1)
- small-molecule activation (1)
- smart surfaces (1)
- snowboarder's ankle (1)
- snowboarder's fracture (1)
- soccer (football) (1)
- social anxiety disorder (1)
- social behaviour (1)
- sociophonetics (1)
- sodium (1)
- soft tissue sarcoma (1)
- soft x-ray photoemission (1)
- soil fauna (1)
- solar cells (1)
- solid tumors (1)
- solid-state NMR spectroscopy (1)
- solid-state emitters (1)
- solitary bees (1)
- solubility (1)
- solubility enhancement (1)
- solvent-dependent fluorescence yield (1)
- somatic mutations (1)
- somatosensory evoked potential (1)
- somatosensory temporal discrimination (1)
- somatostatin receptor (1)
- spa typing (1)
- spacer-controlled self-assembly (1)
- spacing effect (1)
- spatial analyses (1)
- spatial heterogeneity (1)
- spatial scale (1)
- species richness (1)
- species‐area hypothesis (1)
- specific heat (1)
- sphingomyelinase (1)
- sphingosine kinase (1)
- sphingosine kinase inhibitor SKI-II (1)
- sphingosine-1-phosphate (1)
- spin polarization (1)
- spin relaxation (1)
- spin transport (1)
- spinal muscular atrophy (1)
- spleen (1)
- split renal function (1)
- sporidia (1)
- standardized reporting (1)
- standing (1)
- starPEG (1)
- starPEG hydrogel (1)
- startle response (1)
- static vs. dynamic faces (1)
- statistical distributions (1)
- statistical models (1)
- steering (1)
- stem Cells (1)
- stem cell transplantation (1)
- stereospecific sythesis (1)
- stereotactic body radiation therapy (1)
- stereotactic irradiation (1)
- steric effects (1)
- steroid-resistant aGvHD (1)
- stigma (1)
- storage-pool diseases (1)
- storytelling (1)
- strain rate (1)
- strength training (1)
- stress (1)
- stress fiber (1)
- stress tolerance (1)
- stroke management (1)
- stromal vascular fraction (1)
- strong coupling (1)
- strong light matter coupling (1)
- structural disruption (1)
- structural restriction (1)
- structure-activity (1)
- structure-activity relationship (1)
- structure-activity relationships (1)
- structured illumination microscopy (1)
- subadditivity (1)
- subarachnoid hemorrhage (1)
- submicroscopic chromosome rearrangement (1)
- subsarcolemmal mitochondria (1)
- substandard and falsified medicines from the Congo (1)
- substituent (1)
- subsurface hydrology (1)
- sulfoimines (1)
- sulfur (1)
- super resolution microscopy (1)
- super-resolution fluorescence microscopy (1)
- super-resolution microscopy (1)
- superresolution (1)
- suppressor cells (1)
- suppressor mutation (1)
- surface functionalization (1)
- surface plasmon (1)
- surface transport (1)
- surface water (1)
- surfaces, interfaces and thin films (1)
- surgical and invasive medical procedures (1)
- surgical site infection (1)
- survival analysis (1)
- synapses (1)
- synchrotron radiation (1)
- synchrotron radiatoren (1)
- synergistic effect (1)
- synthetic biology (1)
- systematic affiliation (1)
- systematic drug targeting (1)
- targeted bisulfite sequencing (1)
- targeted therapies (1)
- taxonomy (1)
- telemedicine (1)
- temozolomide (1)
- temperature‐mediated resource exploitation hypothesis (1)
- temperature‐richness hypothesis (1)
- temporal discrimination threshold (1)
- temporal lobe epilepsy (1)
- tendon-derived stem cell (1)
- terrestrial LiDAR (1)
- theranostics (1)
- therapy (1)
- therapy response (1)
- therapy simulation (1)
- thermal remote sensing (1)
- thiol-ene (1)
- threshold discrimination identification test (1)
- thrombo-inflammation (1)
- thrombolysis (1)
- thrombolysis (tPA) (1)
- thrombosis (1)
- tight junctions (1)
- time lag (1)
- time series (1)
- time-resolved photoelectron spectroscopy (1)
- time-resolved spectroscopy (1)
- tisindoline (1)
- top-down processing (1)
- topminnow (1)
- topological insulators (1)
- topological matter (1)
- total body irradiation/busulfan (1)
- toxicity (1)
- trans-acting 2'-5' adenylyl transferase ribozymes (1)
- transcranial magnetic simulation (TMS) (1)
- transcription (1)
- transcription deficiency (1)
- transcriptome (1)
- transcriptomics (1)
- transfer hydrogenation (1)
- transient absorption (1)
- transient dynamics (1)
- transient elastography (1)
- transient ischemic attack (1)
- transient middle cerebral artery occlusion (1)
- transition metal (1)
- transition metall dichalcogenide monolayer (1)
- transmission (1)
- transplantation (1)
- transposable elements (1)
- treatment (1)
- tree cavities (1)
- triacylglycerides (1)
- triarylboranes (1)
- triple bonds (1)
- triquinacene derivatives (1)
- trivalent boron (1)
- trypanosomes (1)
- tryptophan hydroxylase 2 (1)
- tumor burden (1)
- tumor control probability (1)
- tumor heterogeneity (1)
- tumor suppressor miRNA (1)
- tumour (1)
- tumour-necrosis factors (1)
- two-component (1)
- two-photon absorption (1)
- tyloses (1)
- type VII secretion system (1)
- ubiquitin ligase (1)
- ubiquitylation (ubiquitination) (1)
- uncanny valley (1)
- uncertainties (1)
- uncertainty (1)
- uneven-aged mountainous (1)
- unmanaged broadleaved forests (1)
- unnecessary alarm (1)
- unsaturated fatty acids (1)
- upconversion (1)
- uptake (1)
- urban environments (1)
- uremic toxins (1)
- urinary tract infections (1)
- vaccinia (1)
- variability (1)
- vasculitis (1)
- verdünnt magnetische Halbleiter (1)
- vertebral body (1)
- vertical and radial variation (1)
- very high energies (VHE) (1)
- very long-chain aliphatic compounds (1)
- vessel lumen diameter (1)
- vessel wall resident stem cells (1)
- vestibular schwannoma (1)
- viability (1)
- video laryngoscopy (1)
- virotherapy (1)
- virtual isocenter (1)
- virus (1)
- viruses (1)
- visual orientation (1)
- visual perception (1)
- visual realism (1)
- vitamin D (1)
- vitamins (1)
- vocational education (1)
- voice-face matching (1)
- volume overload (1)
- voluntary exhaustion (1)
- voxel-based morphometry (1)
- walking (1)
- waste sorting (1)
- water balance (1)
- watershed (1)
- weightlifting (1)
- well-being (1)
- white matter lesions (1)
- whole-genome duplication (1)
- whole-genome sequencing (1)
- wild bees (1)
- wood anatomy (1)
- work (1)
- work capacity evaluation (1)
- work engagement (1)
- work performance (1)
- youth (1)
- zeitaufgelöste Spektroskopie (1)
- zielgerichtete Behandlung (1)
- zinc oxide (1)
- zinc oxide nanoparticles (1)
- zonal construct (1)
- zooming (1)
- État d'Imo (1)
- β3 adrenergic receptor (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (97)
- Graduate School of Life Sciences (51)
- Physikalisches Institut (44)
- Medizinische Klinik und Poliklinik II (33)
- Institut für Psychologie (32)
- Institut für Anorganische Chemie (27)
- Institut für Organische Chemie (27)
- Neurologische Klinik und Poliklinik (27)
- Institut für deutsche Philologie (24)
- Neuphilologisches Institut - Moderne Fremdsprachen (24)
Schriftenreihe
Sonstige beteiligte Institutionen
- VolkswagenStiftung (24)
- Johns Hopkins School of Medicine (2)
- Bio-Imaging Center Würzburg (1)
- CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - the development agency of the Brazilian Federal Government (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg (1)
- DAAD - Deutscher Akademischer Austauschdienst (1)
- Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany (1)
- Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden (1)
- Department of Medicine A, University Hospital of Münster, Münster, Germany (1)
- Ernst Strüngmann Institute for Neuroscience in Cooperation with Max Planck Society (ESI) (1)
ResearcherID
- B-4606-2017 (1)
Background
Shotgun metagenomes contain a sample of all the genomic material in an environment, allowing for the characterization of a microbial community. In order to understand these communities, bioinformatics methods are crucial. A common first step in processing metagenomes is to compute abundance estimates of different taxonomic or functional groups from the raw sequencing data.
Given the breadth of the field, computational solutions need to be flexible and extensible, enabling the combination of different tools into a larger pipeline.
Results
We present NGLess and NG-meta-profiler. NGLess is a domain specific language for describing next-generation sequence processing pipelines. It was developed with the goal of enabling user-friendly computational reproducibility. It provides built-in support for many common operations on sequencing data and is extensible with external tools with configuration files.
Using this framework, we developed NG-meta-profiler, a fast profiler for metagenomes which performs sequence preprocessing, mapping to bundled databases, filtering of the mapping results, and profiling (taxonomic and functional). It is significantly faster than either MOCAT2 or htseq-count and (as it builds on NGLess) its results are perfectly reproducible.
Conclusions
NG-meta-profiler is a high-performance solution for metagenomics processing built on NGLess. It can be used as-is to execute standard analyses or serve as the starting point for customization in a perfectly reproducible fashion.
NGLess and NG-meta-profiler are open source software (under the liberal MIT license) and can be downloaded from https://ngless.embl.de or installed through bioconda.
Background
Temporal lobe epilepsy (TLE) with hippocampal sclerosis (HS) is a common pharmaco-resistant epilepsy referred for adult epilepsy surgery. Though associated with prolonged febrile seizures (FS) in childhood, the neurobiological basis for this relationship is not fully understood and currently no preventive or curative therapies are available. DNA methylation, an epigenetic mechanism catalyzed by DNA methyltransferases (DNMTs), potentially plays a pivotal role in epileptogenesis associated with FS. In an attempt to start exploring this notion, the present cross-sectional pilot study investigated whether global DNA methylation levels (5-mC and 5-hmC markers) and DNMT isoforms (DNMT1, DNMT3a1, and DNMT3a2) expression would be different in hippocampal and neocortical tissues between controls and TLE patients with or without a history of FS.
Results
We found that global DNA methylation levels and DNMT3a2 isoform expression were lower in the hippocampus for all TLE groups when compared to control patients, with a more significant decrease amongst the TLE groups with a history of FS. Interestingly, we showed that DNMT3a1 expression was severely diminished in the hippocampus of TLE patients with a history of FS in comparison with control and other TLE groups. In the neocortex, we found a higher expression of DNMT1 and DNMT3a1 as well as increased levels of global DNA methylation for all TLE patients compared to controls.
Conclusion
Together, the findings of this descriptive cross-sectional pilot study demonstrated brain region-specific changes in DNMT1 and DNMT3a isoform expression as well as global DNA methylation levels in human TLE with or without a history of FS. They highlighted a specific implication of DNMT3a isoforms in TLE after FS. Therefore, longitudinal studies that aim at targeting DNMT3a isoforms to evaluate the potential causal relationship between FS and TLE or treatment of FS-induced epileptogenesis seem warranted.
Background and Objective: Staphylococcus aureus is one of the major pathogens of nosocomial infections as wells as community-acquired (CA) infections worldwide. So far, large-scale comprehensive molecular and epidemiological characterisation of S. aureus from very diverse settings has not been carried out in India. The objective of this study is to evaluate the molecular, epidemiological and virulence characteristics of S. aureus in both community and hospital settings in Chennai, southern India. Methods: S. aureus isolates were obtained from four different groups (a) healthy individuals from closed community settings, (b) inpatients from hospitals, (c) outpatients from hospitals, representing isolates of hospital-community interface and (d) HIV-infected patients to define isolates associated with the immunocompromised. Antibiotic susceptibility testing, multiplex polymerase chain reactions for detection of virulence and resistance determinants, molecular typing including Staphylococcal cassette chromosome mec (SCCmec) and agr typing, were carried out. Sequencing-based typing was done using spa and multilocus sequence typing (MLST) methods. Clonal complexes (CC) of hospital and CA methicillin-resistant S. aureus (MRSA) were identified and compared for virulence and resistance.
Results and Conclusion: A total of 769 isolates of S. aureus isolates were studied. The prevalence of MRSA was found to be 7.17%, 81.67%, 58.33% and 22.85% for groups a, b, c and d, respectively. Of the four SCCmec types (I, III, IV and V) detected, SCCmec V was found to be predominant. Panton-Valentine leucocidin toxin genes were detected among MRSA isolates harbouring SCCmec IV and V. A total of 78 spa types were detected, t657 being the most prevalent. 13 MLST types belonging to 9 CC were detected. CC1 (ST-772, ST-1) and CC8 (ST238, ST368 and ST1208) were found to be predominant among MRSA. CA-MRSA isolates with SCCmec IV and V were isolated from all study groups including hospitalised patients and were found to be similar by molecular tools. This shows that CA MRSA has probably infiltrated into the hospital settings.
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today's technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics.
Background
Increasing bacterial resistance to antibiotics is a serious problem worldwide. We sought to record the acquisition of antibiotic-resistant Escherichia coli (E. coli) in healthy infants in Northern Thailand and investigated potential determinants.
Methods
Stool samples from 142 infants after birth, at ages 2wk, 2mo, 4 to 6mo, and 1y, and parent stool samples were screened for E. coli resistance to tetracycline, ampicillin, co-trimoxazole, and cefazoline by culture, and isolates were further investigated for multiresistance by disc diffusion method. Pulsed-field gel electrophoresis was performed to identify persistent and transmitted strains. Genetic comparison of resistant and transmitted strains was done by multilocus sequence typing (MLST) and strains were further investigated for extra- and intra-intestinal virulence factors by multiplex PCR.
Results
Forty-seven (33%) neonatal meconium samples contained resistant E. coli. Prevalence increased continuously: After 1y, resistance proportion (tetracycline 80%, ampicillin 72%, co-trimoxazole 66%, cefazoline 35%) almost matched those in parents. In 8 infants (6%), identical E. coli strains were found in at least 3 sampling time points (suggesting persistence). Transmission of resistant E. coli from parents to child was observed in only 8 families. MLST showed high diversity. We could not identify any virulence genes or factors associated with persistence, or transmission of resistant E. coli. Full-term, vaginal birth and birth in rural hospital were identified as risk factors for early childhood colonization with resistant E. coli.
Conclusion
One third of healthy Thai neonates harboured antibiotic-resistant E. coli in meconium. The proportion of resistant E. coli increased during the first year of life almost reaching the value in adults. We hypothesize that enhancement of infection control measures and cautious use of antibiotics may help to control further increase of resistance.
Background
Colonization with Staphylococcus aureus has been identified as a risk for subsequent occurrence of infection. This study investigated the relationship between S. aureus colonization of patients and healthcare workers (HCWs), and subsequent surgical site infections (SSI).
Methods
Between December 2014 and September 2015, a total of 930 patients and 143 HCWs were enrolled from the Bugando Medical Centre and Sekou Toure hospital in Mwanza, Tanzania. On admission and discharge nasal swabs, with an additional of wound swab for those who developed SSI were collected from patients whereas HCWs were swabbed once. Identification and antimicrobial susceptibility testing were done by VITEK-MS and VITEK-2, respectively. Detection of Panton Valentine leukocidin (PVL) and mecA genes was done by PCR. S. aureus isolates were further characterized by spa typing and Multi-Locus Sequence Typing (MLST).
Results
Among 930 patients screened for S. aureus on admission, 129 (13.9%) were positive of which 5.4% (7/129) were methicillin-resistant S. aureus (MRSA). Amongst 363 patients rescreened on discharge, 301 patients had been tested negative on admission of whom 29 (9.6%) turned positive after their hospital stay. Three (10.3%) of the 29 acquired S. aureus were MRSA. Inducible Clindamycin resistance occurred more often among acquired S. aureus isolates than among isolates from admission [34.5% (10/29) vs. 17.1% (22/129), P = 0.018]. S. aureus contributed to 21.1% (n = 12) of the 57 cases of investigated SSIs among 536 patients followed. Seven out of eight S. aureus carriage/infection pairs had the same spa and sequence types. The previously reported dominant PVL-positive ST88 MRSA strain with spa type t690 was detected in patients and HCW.
Conclusion
A significant proportion of patients acquired S. aureus during hospitalization. The finding of more than 90% of S. aureus SSI to be of endogenous source underscores the need of improving infection prevention and control measures including screening and decolonization of high risk patients.
Background
The heart-to-mediastinum (H/M) ratio is a commonly used parameter to measure cardiac I-123 metaiodobenzylguanidine (MIBG) uptake. Since the H/M ratio is substantially influenced by the collimator type, we investigated whether an empirical linear conversion of H/M ratios between camera systems with low-energy (LE) and medium-energy (ME) collimator is possible.
Methods
We included 18 patients with parkinsonism who were referred to one of the two participating molecular imaging facilities for the evaluation of cardiac sympathetic innervation by MIBG scintigraphy. Two consecutive planar image datasets were acquired with LE and ME collimators at 4 h after MIBG administration. Linear regression analyses were performed to describe the association between the H/M ratios gained with both collimator settings, and the accuracy of a linear transfer of the H/M ratio between collimators and across centers was assessed using a leave-one-out procedure.
Results
H/M ratios acquired with LE and ME collimators showed a strong linear relationship both within each imaging facility (R\(^2\) = 0.99, p < 0.001 and R\(^2\) = 0.90, p < 0.001) and across centers (H/M-LE = 0.41 × H/M-ME + 0.63, R\(^2\) = 0.97, p < 0.001). A linear conversion of H/M ratios between collimators and across centers was estimated to be very accurate (mean absolute error 0.05 ± 0.04; mean relative absolute error 3.2 ± 2.6%).
Conclusions
The present study demonstrates that a simple linear conversion of H/M ratios acquired with different collimators is possible with high accuracy. This should greatly facilitate the exchange of normative data between settings and pooling of data from different institutions.
Background
Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with gene expression regulatory function, has been reported in all types of epithelial and haematological cancers. In particular, miR-221-5p alterations have been reported in PCa.
Methods
miRNA expression data was retrieved from a comprehensive publicly available dataset of 218 PCa patients (GSE21036) and miR-221-5p expression levels were analysed. The functional role of miR-221-5p was characterised in androgen- dependent and androgen- independent PCa cell line models (C4–2 and PC-3M-Pro4 cells) by miR-221-5p overexpression and knock-down experiments. The metastatic potential of highly aggressive PC-3M-Pro4 cells overexpressing miR-221-5p was determined by studying extravasation in a zebrafish model. Finally, the effect of miR-221-5p overexpression on the growth of PC-3M-Pro4luc2 cells in vivo was studied by orthotopic implantation in male Balb/cByJ nude mice and assessment of tumor growth.
Results
Analysis of microRNA expression dataset for human primary and metastatic PCa samples and control normal adjacent benign prostate revealed miR-221-5p to be significantly downregulated in PCa compared to normal prostate tissue and in metastasis compared to primary PCa. Our in vitro data suggest that miR-221-5p overexpression reduced PCa cell proliferation and colony formation. Furthermore, miR-221-5p overexpression dramatically reduced migration of PCa cells, which was associated with differential expression of selected EMT markers. The functional changes of miR-221-5p overexpression were reversible by the loss of miR-221-5p levels, indicating that the tumor suppressive effects were specific to miR-221-5p. Additionally, miR-221-5p overexpression significantly reduced PC-3M-Pro4 cell extravasation and metastasis formation in a zebrafish model and decreased tumor burden in an orthotopic mouse model of PCa.
Conclusions
Together these data strongly support a tumor suppressive role of miR-221-5p in the context of PCa and its potential as therapeutic target.
Background
The aim of this analysis was to model the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer.
Methods
The analysis is based on pooled data from two retrospective SBRT databases for pulmonary and hepatic metastases from 27 centers from Germany and Switzerland. Only patients with metastases from colorectal cancer were considered to avoid histology as a confounding factor. An illness-death model was employed to model the relationship between LC and OS.
Results
Three hundred eighty-eight patients with 500 metastatic lesions (lung n = 209, liver n = 291) were included and analyzed. Median follow-up time for local recurrence assessment was 12.1 months. Ninety-nine patients with 112 lesions experienced local failure. Seventy-one of these patients died after local failure. Median survival time was 27.9 months in all patients and 25.4 months versus 30.6 months in patients with and without local failure after SBRT. The baseline risk of death after local failure exceeds the baseline risk of death without local failure at 10 months indicating better survival with LC.
Conclusion
In CRC patients with lung or liver metastases, our findings suggest improved long-term OS by achieving metastatic disease control using SBRT in patients with a projected OS estimate of > 12 months.
Background
The aim of this study was to review the patient rated outcome (PROM) of surgically treated fractures to the lateral process of the talus (LPTF) and identify factors influencing the outcome.
Methods
Retrospective study with a current follow-up. Eligible were all patients treated surgically for a LPTF (n = 23) with a minimum follow-up of one year. Demographics, medical history, trauma mechanism, fracture characteristics, concomitant injuries, treatment details, complications, return to work and sports were assessed retrospectively. The current follow-up included the VAS FA, Karlsson Score, and SF-12. The primary outcome was the VAS FA. Secondary aim was the identification of parameters influencing the PROMs.
Results
22 patients (96% follow-up) with a mean age of 32 ± 9 (18 to 49) years were included. 73% suffered a Hawkins Type 1, 23% a Type 2, and one patient a Type 3 fracture. 82% suffered concomitant injuries. 9% suffered minor surgical side infections, 50% developed symptomatic subtalar osteoarthritis. At final follow-up (44 ± 2 (12 to 97) months), the mean VAS FA Overall was 77 ± 21 (20 to 100), the Karlsson Score 72 ± 21 (34 to 97), and for the SF 12 the PCS 53 ± 8 (36 to 64) and the MCS 53 ± 7 (32 to 63). 50% of patients returned to their previous level of sports. Hawkins Type 1 fractures resulted in better VAS FA Overall score than Type 2 fractures. Posttraumatic subtalar osteoarthritis was the independent factor associated to a poor patient rated outcome (VAS FA, Karlsson Score).
Conclusion
After a follow-up of over 3.5 years, surgically treated LPTF resulted in only moderate results. 50% suffered posttraumatic symptomatic subtalar osteoarthritis, which was the primary independent parameter for a poor outcome following LPTF.
Level of evidence
Level III.
Background
The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammatory disease periodontitis and oral cancer. Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that aimed to identify biologically active methylation marks of the oral masticatory mucosa that are associated with smoking.
Results
Ex vivo biopsies of 18 current smokers and 21 never smokers were analysed with the Infinium Methylation EPICBeadChip and combined with whole transcriptome RNA sequencing (RNA-Seq; 16 mio reads per sample) of the same samples. We analysed the associations of CpG methylation values with cigarette smoking and smoke pack year (SPY) levels in an analysis of covariance (ANCOVA). Nine CpGs were significantly associated with smoking status, with three CpGs mapping to the genetic region of CYP1B1 (cytochrome P450 family 1 subfamily B member 1;best p=5.5x10(-8)) and two mapping to AHRR (aryl-hydrocarbon receptor repressor; best p=5.9x10(-9)). In the SPY analysis, 61 CpG sites at 52 loci showed significant associations of the quantity of smoking with changes in methylation values. Here, the most significant association located to the gene CYP1B1, with p=4.0x10(-10). RNA-Seq data showed significantly increased expression of CYP1B1 in smokers compared to non-smokers (p=2.2x10(-14)), together with 13 significantly upregulated transcripts. Six transcripts were significantly downregulated. No differential expression was observed for AHRR. In vitro studies with gingival fibroblasts showed that cigarette smoke extract directly upregulated the expression of CYP1B1.
Conclusion
This study validated the established role of CYP1B1 and AHRR in xenobiotic metabolism of tobacco smoke and highlights the importance of epigenetic regulation for these genes. For the first time, we give evidence of this role for the oral masticatory mucosa.
Cristae architecture is important for the function of mitochondria, the organelles that play the central role in many cellular processes. The mitochondrial contact site and cristae organizing system (MICOS) together with the sorting and assembly machinery (SAM) forms the mitochondrial intermembrane space bridging complex (MIB), a large protein complex present in mammalian mitochondria that partakes in the formation and maintenance of cristae. We report here a new subunit of the mammalian MICOS/MIB complex, an armadillo repeat-containing protein 1 (ArmC1). ArmC1 localizes both to cytosol and mitochondria, where it associates with the outer mitochondrial membrane through its carboxy-terminus. ArmC1 interacts with other constituents of the MICOS/MIB complex and its amounts are reduced upon MICOS/MIB complex depletion. Mitochondria lacking ArmC1 do not show defects in cristae structure, respiration or protein content, but appear fragmented and with reduced motility. ArmC1 represents therefore a peripheral MICOS/MIB component that appears to play a role in mitochondrial distribution in the cell.
Background: Culturing of cells is typically performed on standard tissue culture plates generating growth conditions, which in general do not reflect the native three-dimensional cellular environment. Recent investigations provide insights in parameters, which strongly affect the general cellular behavior triggering essential processes such as cell differentiation. The physical properties of the used material, such as stiffness, roughness, or topology, as well as the chemical composition of the cell-surface interface are shown to play a key role in the initiation of particular cellular responses. Methods: We extended our previous research, which identified thin films of metallo-supramolecular coordination polyelectrolytes (MEPEs) as substrate to trigger the differentiation of muscular precursor cells. Results: Here, we show that the same MEPEs similarly stimulate the osteogenic differentiation of pre-osteoblasts. Remarkably, MEPE modified surfaces also trigger the differentiation of primary bone derived mesenchymal stem cells (BMSCs) towards the osteogenic lineage. Conclusion: This result leads to the conclusion that these surfaces individually support the specification of cell differentiation toward lineages that correspond to the natural commitment of the particular cell types. We, therefore, propose that Fe-MEPEs may be used as scaffold for the treatment of defects at least in muscular or bone tissue.
The reaction products of the picolyl radicals at high temperature were characterized by mass‐selective threshold photoelectron spectroscopy in the gas phase. Aminomethylpyridines were pyrolyzed to initially produce picolyl radicals (m /z =92). At higher temperatures further thermal reaction products are generated in the pyrolysis reactor. All compounds were identified by mass‐selected threshold photoelectron spectroscopy and several hitherto unexplored reactive molecules were characterized. The mechanism for several dissociation pathways was outlined in computations. The spectrum of m /z =91, resulting from hydrogen loss of picolyl, shows four isomers, two ethynyl pyrroles with adiabatic ionization energies (IE\(_{ad}\)) of 7.99 eV (2‐ethynyl‐1H ‐pyrrole) and 8.12 eV (3‐ethynyl‐1H ‐pyrrole), and two cyclopentadiene carbonitriles with IE′s of 9.14 eV (cyclopenta‐1,3‐diene‐1‐carbonitrile) and 9.25 eV (cyclopenta‐1,4‐diene‐1‐carbonitrile). A second consecutive hydrogen loss forms the cyanocyclopentadienyl radical with IE′s of 9.07 eV (T\(_0\)) and 9.21 eV (S\(_1\)). This compound dissociates further to acetylene and the cyanopropynyl radical (IE=9.35 eV). Furthermore, the cyclopentadienyl radical, penta‐1,3‐diyne, cyclopentadiene and propargyl were identified in the spectra. Computations indicate that dissociation of picolyl proceeds initially via a resonance‐stabilized seven‐membered ring.
Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The tumor suppressor FBW7 is commonly mutated or down-regulated in human LSCC, and oncogenic KRasG12D activation combined with Fbxw7 inactivation in mice (KF model) caused both LSCC and LADC. Lineage-tracing experiments showed that CC10(+), but not basal, cells are the cells of origin of LSCC in KF mice. KF LSCC tumors recapitulated human LSCC resistance to cisplatin-based chemotherapy, and we identified LUBAC-mediated NF-kappa B signaling as a determinant of chemotherapy resistance in human and mouse. Inhibition of NF-kappa B activation using TAK1 or LUBAC inhibitors resensitized LSCC tumors to cisplatin, suggesting a future avenue for LSCC patient treatment.
Organoids derived from human pluripotent stem cells are interesting models to study mechanisms of morphogenesis and promising platforms for disease modeling and drug screening. However, they mostly remain incomplete as they lack stroma, tissue resident immune cells and in particular vasculature, which create important niches during development and disease. We propose, that the directed incorporation of mesodermal progenitor cells (MPCs) into organoids will overcome the aforementioned limitations. In order to demonstrate the feasibility of the method, we generated complex human tumor as well as neural organoids. We show that the formed blood vessels display a hierarchic organization and mural cells are assembled into the vessel wall. Moreover, we demonstrate a typical blood vessel ultrastructure including endothelial cell-cell junctions, a basement membrane as well as luminal caveolae and microvesicles. We observe a high plasticity in the endothelial network, which expands, while the organoids grow and is responsive to anti-angiogenic compounds and pro-angiogenic conditions such as hypoxia. We show that vessels within tumor organoids connect to host vessels following transplantation. Remarkably, MPCs also deliver Iba1\(^+\) cells that infiltrate the neural tissue in a microglia-like manner.
We analyze the processing of cereals and its role at Early Neolithic Göbekli Tepe, southeastern Anatolia (10th / 9th millennium BC), a site that has aroused much debate in archaeological discourse. To date, only zooarchaeological evidence has been discussed in regard to the subsistence of its builders. Göbekli Tepe consists of monumental round to oval buildings, erected in an earlier phase, and smaller rectangular buildings, built around them in a partially contemporaneous and later phase. The monumental buildings are best known as they were in the focus of research. They are around 20 m in diameter and have stone pillars that are up to 5.5 m high and often richly decorated. The rectangular buildings are smaller and–in some cases–have up to 2 m high, mostly undecorated, pillars. Especially striking is the number of tools related to food processing, including grinding slabs/bowls, handstones, pestles, and mortars, which have not been studied before. We analyzed more than 7000 artifacts for the present contribution. The high frequency of artifacts is unusual for contemporary sites in the region. Using an integrated approach of formal, experimental, and macro- / microscopical use-wear analyses we show that Neolithic people at Göbekli Tepe have produced standardized and efficient grinding tools, most of which have been used for the processing of cereals. Additional phytolith analysis confirms the massive presence of cereals at the site, filling the gap left by the weakly preserved charred macro-rests. The organization of work and food supply has always been a central question of research into Göbekli Tepe, as the construction and maintenance of the monumental architecture would have necessitated a considerable work force. Contextual analyses of the distribution of the elements of the grinding kit on site highlight a clear link between plant food preparation and the rectangular buildings and indicate clear delimitations of working areas for food production on the terraces the structures lie on, surrounding the circular buildings. There is evidence for extensive plant food processing and archaeozoological data hint at large-scale hunting of gazelle between midsummer and autumn. As no large storage facilities have been identified, we argue for a production of food for immediate use and interpret these seasonal peaks in activity at the site as evidence for the organization of large work feasts.
Purpose: The effective point of measurement (EPOM) of cylindrical ionization chambers differs from their geometric center. The exact shift depends on chamber construction details, above all the chamber size, and to some degree on the field-size and beam quality. It generally decreases as the chamber dimensions get smaller. In this work, effective points of measurement in small photon fields of a range of cylindrical chambers of different sizes are investigated, including small chambers that have not been studied previously.
Methods: In this investigation, effective points of measurement for different ionization chambers (Farmer type, scanning chambers, micro-ionization chambers) and solid state detectors were determined by measuring depth-ionization curves in a 6 MV beam in field sizes between 2 9 2 cm2 and 10 9 10 cm2 and comparing those curves with curves measured with plane-parallel chambers.
Results: It was possible to average the results to one shift per detector, as the results were sufficiently independent of the studied field sizes. For cylindrical ion chambers, shifts of the EPOM were determined to be between 0.49 and 0.30 times the inner chamber radius from the reference point.
Conclusions: We experimentally confirmed the previously reported decrease of the EPOM shift with decreasing detector size. Highly accurate data for a large range of detectors, including new very small ones, were determined. Thus, small chambers noticeably differ from the 0.5-times to 0.6-times the inner chamber radius recommendations in current dosimetry protocols. The detector-individual EPOMs need to be considered for measurements of depth-dose curves.
o build, run, and maintain reliable manufacturing machines, the condition of their components has to be continuously monitored. When following a fine-grained monitoring of these machines, challenges emerge pertaining to the (1) feeding procedure of large amounts of sensor data to downstream processing components and the (2) meaningful analysis of the produced data. Regarding the latter aspect, manifold purposes are addressed by practitioners and researchers. Two analyses of real-world datasets that were generated in production settings are discussed in this paper. More specifically, the analyses had the goals (1) to detect sensor data anomalies for further analyses of a pharma packaging scenario and (2) to predict unfavorable temperature values of a 3D printing machine environment. Based on the results of the analyses, it will be shown that a proper management of machines and their components in industrial manufacturing environments can be efficiently supported by the detection of anomalies. The latter shall help to support the technical evangelists of the production companies more properly.
Background: Recent research has shown an increased risk of accidents and injuries in ADHD patients, which could potentially be reduced by stimulant treatment. Therefore, the first aim of our study was to evaluate the prevalence of adult ADHD in a trauma surgery population. The second aim was to investigate accident mechanisms and circumstances which could be specific to ADHD patients, in comparison to the general population. Methods: We screened 905 accident victims for ADHD using the ASRS 18-item self-report questionnaire. The basic demographic data and circumstances of the accidents were also assessed. Results: Prevalence of adult ADHD was found to be 6.18% in our trauma surgery patient sample. ADHD accident victims reported significantly higher rates of distraction, stress and overconfidence in comparison to non-ADHD accident victims. Overconfidence and being in thoughts as causal mechanisms for the accidents remained significantly higher in ADHD patients after correction for multiple comparison. ADHD patients additionally reported a history of multiple accidents. Conclusion: The majority of ADHD patients in our sample had not previously been diagnosed and were therefore not receiving treatment. The results subsequently suggest that general ADHD screening in trauma surgery patients may be useful in preventing further accidents in ADHD patients. Furthermore, psychoeducation regarding specific causal accident mechanisms could be implemented in ADHD therapy to decrease accident incidence rate
Objective
The aim of this study was to determine the prevalence of Neisseria meningitidis, Haemophilus influenzae, Streptococcus pneumoniae, group A Streptococcus (GAS), and Staphylococcus aureus in asymptomatic elderly people and to unravel risk factors leading to colonization.
Methods
A multi-centre cross-sectional study was conducted including 677 asymptomatic adults aged 65 years or more, living at home or in nursing homes. Study areas were Greater Aachen (North-Rhine-Westphalia) and Wuerzburg (Bavaria), both regions with medium to high population density. Nasal and oropharyngeal swabs as well as questionnaires were collected from October 2012 to May 2013. Statistical analysis included multiple logistic regression models.
Results
The carriage rate was 1.9% ([95%CI: 1.0–3.3%]; 13/677) for H. influenzae, 0.3% ([95%CI: 0–1.1%]; 2/677) for N. meningitidis and 0% ([95% CI: 0–0.5%]; 0/677) for S. pneumoniae and GAS. Staphylococcus aureus was harboured by 28.5% of the individuals ([95% CI: 25.1–32.1%]; 193/677) and 0.7% ([95% CI: 0.2–1.7%]; 5/677) were positive for methicillin-resistant S. aureus. Among elderly community-dwellers colonization with S. aureus was significantly associated with higher educational level (adjusted OR: 1.905 [95% CI: 1.248–2.908]; p = 0.003). Among nursing home residents colonization was associated with being married (adjusted OR: 3.367 [1.502–7.546]; p = 0.003).
Conclusion
The prevalence of N. meningitidis, H. influenzae, S. pneumoniae and GAS was low among older people in Germany. The S. aureus rate was expectedly high, while MRSA was found in less than 1% of the individuals.
Introduction: Striatal dopamine depletion disrupts basal ganglia function and causes Parkinson’s disease (PD). The pathophysiology of the dopamine-dependent relationship between basal ganglia signaling and motor control, however, is not fully understood. We obtained simultaneous recordings of local field potentials (LFPs) from the subthalamic nucleus (STN) and electromyograms (EMGs) in patients with PD to investigate the impact of dopaminergic state and movement on long-range beta functional connectivity between basal ganglia and lower motor neurons.
Methods: Eight PD patients were investigated 3 months after implantation of a deep brain stimulation (DBS)-system capable of recording LFPs via chronically-implanted leads (Medtronic, ACTIVA PC+S®). We analyzed STN spectral power and its coherence with EMG in the context of two different movement paradigms (tonic wrist extension vs. alternating wrist extension and flexion) and the effect of levodopa (L-Dopa) intake using an unbiased data-driven approach to determine regions of interest (ROI).
Results: Two ROIs capturing prominent coherence within a grand average coherogram were identified. A trend of a dopamine effect was observed for the first ROI (50–150 ms after movement start) with higher STN-EMG coherence in medicated patients. Concerning the second ROI (300–500 ms after movement start), an interaction effect of L-Dopa medication and movement task was observed with higher coherence in the isometric contraction task compared to alternating movements in the medication ON state, a pattern which was reversed in L-Dopa OFF.
Discussion: L-Dopa medication may normalize functional connectivity between remote structures of the motor system with increased upper beta coherence reflecting a physiological restriction of the amount of information conveyed between remote structures. This may be necessary to maintain simple movements like isometric contraction. Our study adds dynamic properties to the complex interplay between STN spectral beta power and the nucleus’ functional connectivity to remote structures of the motor system as a function of movement and dopaminergic state. This may help to identify markers of neuronal activity relevant for more individualized programming of DBS therapy.
Background
Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, we explore the impact of the Akt inhibitor MK-2206 alone and in combination with the dual PI3K and mTOR inhibitor PI-103 on the radiation sensitivity of glioblastoma cells. In addition, we examine migration of drug-treated cells.
Methods
Using single-cell tracking and wound healing migration tests, colony-forming assay, Western blotting, flow cytometry and electrorotation we examined the effects of MK-2206 and PI-103 and/or irradiation on the migration, radiation sensitivity, expression of several marker proteins, DNA damage, cell cycle progression and the plasma membrane properties in two glioblastoma (DK-MG and SNB19) cell lines, previously shown to differ markedly in their migratory behavior and response to PI3K/mTOR inhibition.
Results
We found that MK-2206 strongly reduces the migration of DK-MG but only moderately reduces the migration of SNB19 cells. Surprisingly, MK-2206 did not cause radiosensitization, but even increased colony-forming ability after irradiation. Moreover, MK-2206 did not enhance the radiosensitizing effect of PI-103. The results appear to contradict the strong depletion of p-Akt in MK-2206-treated cells. Possible reasons for the radioresistance of MK-2206-treated cells could be unaltered or in case of SNB19 cells even increased levels of p-mTOR and p-S6, as compared to the reduced expression of these proteins in PI-103-treated samples. We also found that MK-2206 did not enhance IR-induced DNA damage, neither did it cause cell cycle distortion, nor apoptosis nor excessive autophagy.
Conclusions
Our study provides proof that MK-2206 can effectively inhibit the expression of Akt in two glioblastoma cell lines. However, due to an aberrant activation of mTOR in response to Akt inhibition in PTEN mutated cells, the therapeutic window needs to be carefully defined, or a combination of Akt and mTOR inhibitors should be considered.
Background:
Employees insured in pension insurance, who are incapable of working due to ill health, are entitled to a disability pension. To assess whether an individual meets the medical requirements to be considered as disabled, a work capacity evaluation is conducted. However, there are no official guidelines on how to perform an external quality assurance for this evaluation process. Furthermore, the quality of medical reports in the field of insurance medicine can vary substantially, and systematic evaluations are scarce. Reliability studies using peer review have repeatedly shown insufficient ability to distinguish between high, moderate and low quality. Considering literature recommendations, we developed an instrument to examine the quality of medical experts’reports.
Methods:
The peer review manual developed contains six quality domains (formal structure, clarity, transparency, completeness, medical-scientific principles, and efficiency) comprising 22 items. In addition, a superordinate criterion (survey confirmability) rank the overall quality and usefulness of a report. This criterion evaluates problems of innerlogic and reasoning. Development of the manual was assisted by experienced physicians in a pre-test. We examined the observable variance in peer judgements and reliability as the most important outcome criteria. To evaluate inter-rater reliability, 20 anonymous experts’ reports detailing the work capacity evaluation were reviewed by 19 trained raters (peers). Percentage agreement and Kendall’s W, a reliability measure of concordance between two or more peers, were calculated. A total of 325 reviews were conducted.
Results:
Agreement of peer judgements with respect to the superordinate criterion ranged from 29.2 to 87.5%. Kendall’s W for the quality domain items varied greatly, ranging from 0.09 to 0.88. With respect to the superordinate criterion, Kendall’s W was 0.39, which indicates fair agreement. The results of the percentage agreement revealed systemic peer preferences for certain deficit scale categories.
Conclusion:
The superordinate criterion was not sufficiently reliable. However, in comparison to other reliability studies, this criterion showed an equivalent reliability value. This report aims to encourage further efforts to improve evaluation instruments. To reduce disagreement between peer judgments, we propose the revision of the peer review instrumentand the development and implementation of a standardized rater training to improve reliability.
Brushite cements have been clinically used for irregular bone defect filling applications, and various strategies have been previously reported to modify and improve their physicochemical properties such as strength and injectability. However, strategies to address other limitations of brushite cements such as low radiopacity or acidity without negatively impacting mechanical strength have not yet been reported. In this study, we report the effect of substituting the beta-tricalcium phosphate reactant in brushite cement with baghdadite (Ca\(_3\)ZrSi\(_2\)O\(_9\)), a bioactive zirconium-doped calcium silicate ceramic, at various concentrations (0, 5, 10, 20, 30, 50, and 100 wt%) on the properties of the final brushite cement product. X-ray diffraction profiles indicate the dissolution of baghdadite during the cement reaction, without affecting the crystal structure of the precipitated brushite. EDX analysis shows that calcium is homogeneously distributed within the cement matrix, while zirconium and silicon form cluster-like aggregates with sizes ranging from few microns to more than 50 µm. X-ray images and µ-CT analysis indicate enhanced radiopacity with increased incorporation of baghdadite into brushite cement, with nearly a doubling of the aluminium equivalent thickness at 50 wt% baghdadite substitution. At the same time, compressive strength of brushite cement increased from 12.9 ± 3.1 MPa to 21.1 ± 4.1 MPa with 10 wt% baghdadite substitution. Culture medium conditioned with powdered brushite cement approached closer to physiological pH values when the cement is incorporated with increasing amounts of baghdadite (pH = 6.47 for pure brushite, pH = 7.02 for brushite with 20 wt% baghdadite substitution). Baghdadite substitution also influenced the ionic content in the culture medium, and subsequently affected the proliferative activity of primary human osteoblasts in vitro. This study indicates that baghdadite is a beneficial additive to enhance the radiopacity, mechanical performance and cytocompatibility of brushite cement
Mineral bone cements were actually not developed for their application as bone-bonding agents, but as bone void fillers. In particular, calcium phosphate cements (CPC) are considered to be unsuitable for that application, particularly under moist conditions. Here, we showed the ex vivo ability of different magnesium phosphate cements (MPC) to adhere on bovine cortical bone substrates. The cements were obtained from a mixture of farringtonite (Mg\(_3\)(PO\(_4\))\(_2\)) with different amounts of phytic acid (C\(_6\)H\(_{18}\)O\(_{24}\)P\(_6\), inositol hexaphosphate, IP6), whereas cement setting occurred by a chelation reaction between Mg\(^{2+}\) ions and IP6. We were able to show that cements with 25% IP6 and a powder-to-liquid ratio (PLR) of 2.0 g/mL resulted in shear strengths of 0.81 ± 0.12 MPa on bone even after 7 d storage in aqueous conditions. The samples showed a mixed adhesive–cohesive failure with cement residues on the bone surface as indicated by scanning electron microscopy and energy-dispersive X-ray analysis. The presented material demonstrated appropriate bonding characteristics, which could enable a broadening of the mineral bone cements’ application field to bone adhesives
The heterotrimeric protein kinase SNF1 plays a key role in the metabolic adaptation of the pathogenic yeast Candida albicans. It consists of the essential catalytic α-subunit Snf1, the γ-subunit Snf4, and one of the two β-subunits Kis1 and Kis2. Snf4 is required to release the N-terminal catalytic domain of Snf1 from autoinhibition by the C-terminal regulatory domain, and snf4Δ mutants cannot grow on carbon sources other than glucose. In a screen for suppressor mutations that restore growth of a snf4Δ mutant on alternative carbon sources, we isolated a mutant in which six amino acids between the N-terminal kinase domain and the C-terminal regulatory domain of Snf1 were deleted. The deletion was caused by an intragenic recombination event between two 8-bp direct repeats flanking six intervening codons. In contrast to truncated forms of Snf1 that contain only the kinase domain, the Snf4-independent Snf1\(^{Δ311 − 316}\) was fully functional and could replace wild-type Snf1 for normal growth, because it retained the ability to interact with the Kis1 and Kis2 β-subunits via its C-terminal domain. Indeed, the Snf4-independent Snf1\(^{Δ311 − 316}\) still required the β-subunits of the SNF1 complex to perform its functions and did not rescue the growth defects of kis1Δ mutants. Our results demonstrate that a preprogrammed in-frame deletion event within the SNF1 coding region can generate a mutated form of this essential kinase which abolishes autoinhibition and thereby overcomes growth deficiencies caused by a defect in the γ-subunit Snf4.
Here, we present the unique case of a 51‐year‐old German patient with multiple myeloma excreting Ascaris lumbricoides in his stool five weeks after allogeneic hematopoietic stem cell transplantation. Stool analysis remained negative for the presence of eggs, and there was no eosinophilia in the peripheral blood at any time around stem cell transplantation. The patient was commenced on a three‐day treatment with mebendazole, which was well tolerated. No serious interactions with the concomitant post‐transplant medication or negative effects on the hematopoiesis were observed, and the myeloma still is in complete remission. To our knowledge, this is the first report on excretion of A lumbricoides in the context of allogeneic stem cell transplantation. The case is remarkable with view to the fact that the parasite has supposedly survived all courses of myeloma treatment including autologous and allogeneic conditioning. Parasitosis with A lumbricoides has a worldwide prevalence of about a billion and is extremely rare in northern Europe. Possibly the patient got infected during a trip to Egypt years before multiple myeloma was diagnosed.
Investigating approach-avoidance behavior regarding affective stimuli is important in broadening the understanding of one of the most common psychiatric disorders, social anxiety disorder. Many studies in this field rely on approach-avoidance tasks, which mainly assess hand movements, or interpersonal distance measures, which return inconsistent results and lack ecological validity. Therefore, the present study introduces a virtual reality task, looking at avoidance parameters (movement time and speed, distance to social stimulus, gaze behavior) during whole-body movements. These complex movements represent the most ecologically valid form of approach and avoidance behavior. These are at the core of complex and natural social behavior. With this newly developed task, the present study examined whether high socially anxious individuals differ in avoidance behavior when bypassing another person, here virtual humans with neutral and angry facial expressions. Results showed that virtual bystanders displaying angry facial expressions were generally avoided by all participants. In addition, high socially anxious participants generally displayed enhanced avoidance behavior towards virtual people, but no specifically exaggerated avoidance behavior towards virtual people with a negative facial expression. The newly developed virtual reality task proved to be an ecological valid tool for research on complex approach-avoidance behavior in social situations. The first results revealed that whole body approach-avoidance behavior relative to passive bystanders is modulated by their emotional facial expressions and that social anxiety generally amplifies such avoidance.
Background and purpose: Previous studies delivered contradicting results regarding the relation between the presence of an internal carotid artery stenosis (ICAS) and the occurence of white matter lesions (WMLs). We hypothesize that special characteristics related to the ICAS might be related to the WMLs. We examined the relation between the presence of bilateral ICAS, the degree and length of stenosis and ipsi-, contralateral as well as mean white matter lesion load (MWMLL).
Methods: In a retrospective cohort, patients with ischemic stroke or transient ischemic attack (TIA) as well as ipsi- and/or contralateral ICAS were identified. The length and degree of ICAS, as well as plaque morphology (hypoechoic, mixed or echogenic), were assessed on ultrasound scans and, if available, the length was also measured on magnetic resonance angiography (MRA) scans, and/or digital subtraction angiography (DSA). The WMLs were assessed in 4 areas separately, (periventricular and deep WMLs on each hemispherer), using the Fazekas scale. The MWMLL was calculated as the mean of these four values.
Results: 136 patients with 177 ICAS were identified. A significant correlation between age and MWMLL was observed (Spearman correlation coefficient, ρ = 0.41, p < 0.001). Before adjusting for other risk factors, a significantly positive relation was found between the presence of bilateral ICAS and MWMLL (p = 0.039). The length but not the degree of ICAS showed a very slight trend toward association with ipsilateral WMLs and with MWMLL. In an age-adjusted multivariate logistic regression with MWMLL ≥2 as the outcome measure, atrial fibrillation (OR 3.54, 95% CI 1.12–11.18, p = 0.03), female sex (OR 3.11, 95% CI 1.19–8.11, p = 0.02) and diabetes mellitus (OR 2.76, 95% CI 1.16–6.53, p = 0.02) were significantly related to WMLs, whereas the presence of bilateral stenosis showed a trend toward significance (OR 2.25, 95% CI 0.93–5.45, p = 0.074). No relation was found between plaque morphology and MWMLL, periventricular, or deep WMLs.
Conclusion: We have shown a slight correlation between the length of stenosis and the presence of WMLs which might be due to microembolisation originating from the carotid plaque. However, the presence of bilateral ICAS seems also to be related to WMLs which may point to common underlying vascular risk factors contributing to the occurrence of WML.
Background
Limited data is available to guide the choice of the conditioning regimen for patients with acute myeloid leukemia (AML) undergoing transplant with persistent disease.
Methods
We retrospectively compared outcome of fludarabine-treosulfan (FT), thiotepa-busulfan-fludarabine (TBF), and sequential fludarabine, intermediate dose Ara-C, amsacrine, total body irradiation/busulfan, cyclophosphamide (FLAMSA) conditioning in patients with refractory or relapsed AML.
Results
Complete remission rates at day 100 were 92%, 80%, and 88% for FT, TBF, and FLAMSA, respectively (p=0.13). Non-relapse mortality, incidence of relapse, acute (a) and chronic (c) graft-versus-host disease (GVHD) rates did not differ between the three groups. Overall survival at 2years was 37% for FT, 24% for TBF, and 34% for FLAMSA (p=0.10). Independent prognostic factors for survival were Karnofsky performance score and patient CMV serology (p=0.01; p=0.02), while survival was not affected by age at transplant. The use of anti-thymocyte globulin (ATG) was associated with reduced risk of grade III-IV aGVHD (p=0.02) and cGVHD (p=0.006), with no influence on relapse.
Conclusions
In conclusion, FT, TBF, and FLAMSA regimens provided similar outcome in patients undergoing transplant with active AML. Survival was determined by patient characteristics as Karnofsky performance score and CMV serology, however was not affected by age at transplant. ATG appears able to reduce the incidence of acute and chronic GVHD without influencing relapse risk.
Positron annihilation lifetime spectroscopy (PALS) provides a powerful technique for non-destructive microstructure investigations in a broad field of material classes such as metals, semiconductors, polymers or porous glasses. Even though this method is well established for more than five decades, no proper standardization for the used setup configuration and subsequent data processing exists. Eventually, this could lead to an insufficiency of data reproducibility and avoidable deviations.
Here we present experimentally obtained and simulated data of positron lifetime spectra at various statistics measured on pure tin (4N-Sn) by using a semi-analog/digital setup, where the digital section consists of the DRS4 evaluation board, “Design and performance of the 6 GHz waveform digitizing chip DRS4” [1]. The analog section consists of nuclear instrument modules (NIM), which externally trigger the DRS4 evaluation board to reduce the digitization and, thus, increase the acquisition efficiency. For the experimentally obtained lifetime spectra, 22Na sealed in Kapton foil served as a positron source, whereas 60Co was used for the acquisition of the prompt spectrum, i.e. the quasi instrument response function. Both types of measurements were carried out under the same conditions.
All necessary data and information regarding the data acquisition and data reduction are provided to allow reproducibility by other research groups.
Climate warming has the potential to disrupt plant-pollinator interactions or to increase competition of co-flowering plants for pollinators, due to species-specific phenological responses to temperature. However, studies focusing on the effect of temperature on solitary bee emergence and the flowering onset of their food plants under natural conditions are still rare. We studied the effect of temperature on the phenology of the two spring bees Osmia cornuta and Osmia bicornis, by placing bee cocoons on eleven grasslands differing in mean site temperature. On seven grasslands, we additionally studied the effect of temperature on the phenology of the red-list plant Pulsatilla vulgaris, which was the first flowering plant, and of co-flowering plants with later flowering. With a warming of 0.1°C, the abundance-weighted mean emergence of O. cornuta males advanced by 0.4 days. Females of both species did not shift their emergence. Warmer temperatures advanced the abundance-weighted mean flowering of P. vulgaris by 1.3 days per 0.1°C increase, but did not shift flowering onset of co-flowering plants. Competition for pollinators between P. vulgaris and co-flowering plants does not increase within the studied temperature range. We demonstrate that temperature advances plant flowering more strongly than bee emergence suggesting an increased risk of pollinator limitation for the first flowers of P. vulgaris.
Polymer micelles are an attractive means to solubilize water insoluble compounds such as drugs. Drug loading, formulations stability and control over drug release are crucial factors for drug‐loaded polymer micelles. The interactions between the polymeric host and the guest molecules are considered critical to control these factors but typically barely understood. Here, we compare two isomeric polymer micelles, one of which enables ultra‐high curcumin loading exceeding 50 wt.%, while the other allows a drug loading of only 25 wt.%. In the low capacity micelles, steady‐state fluorescence revealed a very unusual feature of curcumin fluorescence, a high energy emission at 510 nm. Time‐resolved fluorescence upconversion showed that the fluorescence life time of the corresponding species is too short in the high‐capacity micelles, preventing an observable emission in steady‐state. Therefore, contrary to common perception, stronger interactions between host and guest can be detrimental to the drug loading in polymer micelles.
Purpose
4D flow cardiovascular magnetic resonance (CMR) and the assessment of wall shear stress (WSS) are non-invasive tools to study cardiovascular risks in vivo. Major limitations of conventional triggered methods are the long measurement times needed for high-resolution data sets and the necessity of stable electrocardiographic (ECG) triggering. In this work an ECG-free retrospectively synchronized method is presented that enables accelerated high-resolution measurements of 4D flow and WSS in the aortic arch of mice.
Methods
4D flow and WSS were measured in the aortic arch of 12-week-old wildtype C57BL/6 J mice (n = 7) with a radial 4D-phase-contrast (PC)-CMR sequence, which was validated in a flow phantom. Cardiac and respiratory motion signals were extracted from the radial CMR signal and were used for the reconstruction of 4D-flow data. Rigid motion correction and a first order B0 correction was used to improve the robustness of magnitude and velocity data.
The aortic lumen was segmented semi-automatically. Temporally averaged and time-resolved WSS and oscillatory shear index (OSI) were calculated from the spatial velocity gradients at the lumen surface at 14 locations along the aortic arch. Reproducibility was tested in 3 animals and the influence of subsampling was investigated.
Results
Volume flow, cross-sectional areas, WSS and the OSI were determined in a measurement time of only 32 min. Longitudinal and circumferential WSS and radial stress were assessed at 14 analysis planes along the aortic arch. The average longitudinal, circumferential and radial stress values were 1.52 ± 0.29 N/m2, 0.28 ± 0.24 N/m2 and − 0.21 ± 0.19 N/m2, respectively. Good reproducibility of WSS values was observed.
Conclusion
This work presents a robust measurement of 4D flow and WSS in mice without the need of ECG trigger signals. The retrospective approach provides fast flow quantification within 35 min and a flexible reconstruction framework.
Dynamic light scattering is a popular technique to determine the size distribution of small particles in the sub micrometer region. It operates in reciprocal space, by analyzing the signal fluctuations with the photon auto correlation function. Equally, pulsed field gradient magnetic resonance is a technique generating data in the reciprocal space of the density distribution of an object. Here we show the feasibility of employing a magnetic resonance imaging system as a dynamic scattering device similar to dynamic light scattering appliances. By acquiring a time series of single data points from reciprocal space, analogue to dynamic light scattering, we demonstrate the examination of motion patterns of microscopic particles. This method allows the examination of particle dynamics significantly below the spatial resolution of magnetic resonance imaging. It is not limited by relaxation times and covers a wide field of applications for particle or cell motion in opaque media.
Combined MEK‐BRAF inhibition is a well‐established treatment strategy in BRAF‐mutated cancer, most prominently in malignant melanoma with durable responses being achieved through this targeted therapy. However, a subset of patients face primary unresponsiveness despite presence of the activating mutation at position V600E, and others acquire resistance under treatment. Underlying resistance mechanisms are largely unknown, and diagnostic tests to predict tumor response to BRAF‐MEK inhibitor treatment are unavailable.
Multiple myeloma represents the second most common hematologic malignancy, and point mutations in BRAF are detectable in about 10% of patients. Targeted inhibition has been successfully applied, with mixed responses observed in a substantial subset of patients mirroring the widespread spatial heterogeneity in this genomically complex disease. Central nervous system (CNS) involvement is an extremely rare, extramedullary form of multiple myeloma that can be diagnosed in less than 1% of patients. It is considered an ultimate high‐risk feature, associated with unfavorable cytogenetics, and, even with intense treatment applied, survival is short, reaching less than 12 months in most cases. Here we not only describe the first patient with an extramedullary CNS relapse responding to targeted dabrafenib and trametinib treatment, we furthermore provide evidence that a point mutation within the capicua transcriptional repressor (CIC) gene mediated the acquired resistance in this patient.
Osmotic stimulus or stress results in vasopressin release. Animal and human in vitro studies have shown that inflammatory parameters, such as interle ukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), increase in parallel in the central nervous system and bronchial, corneal or intestinal epithelial cell lines in response to osmotic stimulus. Whether osmotic stimulus directly causes a systemic inflammatory response in humans is unknown. We therefore investigated the influence of osmotic stimulus on circulatory markers of systemic inflammation in healthy volunteers. In this prospective cohort study, 44 healthy volunteers underwent a standardized test protocol with an osmotic stimulus leading into the hyperosmotic/hypernatremic range (serum sodium >= 150 mmol/L) by hypertonic saline infusion. Copeptin - a marker indicating vasopressin activity - serum sodium and osmolality, plasma IL-8 and TNF-alpha were measured at baseline and directly after osmotic stimulus. Median (range) serum sodium increased from 141 mmol/L (136, 147) to 151 mmol/L (145, 154) (P < 0.01), serum osmolality increased from 295 mmol/L (281, 306) to 315 mmol/L (304, 325) (P < 0.01). Median (range) copeptin increased from 4.3 pg/L (1.1, 21.4) to 28.8 pg/L (19.9, 43.4) (P < 0.01). Median (range) IL-8 levels showed a trend to decrease from 0.79 pg/mL (0.37, 1.6) to 0.7 pg/mL (0.4, 1.9) (P < 0.09) and TNF-alpha levels decreased from 0.53 pg/mL (0.11, 1.1) to 0.45 pg/mL (0.1 2, 0.97) (P < 0.036). Contrary to data obtained in vitro, circulating proinflammatory cytokines tend to or decrease in human plasma after osmotic stimulus. In this study, osmotic stimulus does not increase circulating markers of systemic inflammation.
Background
Atrial fibrillation (AF) without other stroke risk factors is assumed to have a low annual stroke risk comparable to patients without AF. Therefore, current clinical guidelines do not recommend oral anticoagulation for stroke prevention of AF in patients without stroke risk factors. We analyzed brain magnetic resonance imaging (MRI) imaging to estimate the rate of clinically inapparent (“silent”) ischemic brain lesions in these patients.
Methods
We pooled individual patient-level data from three prospective studies comprising stroke-free patients with symptomatic AF. All study patients underwent brain MRI within 24–48 h before planned left atrial catheter ablation. MRIs were analyzed by a neuroradiologist blinded to clinical data.
Results
In total, 175 patients (median age 60 (IQR 54–67) years, 32% female, median CHA\(_2\)DS\(_2\)-VASc = 1 (IQR 0–2), 33% persistent AF) were included. In AF patients without or with at least one stroke risk factor, at least one silent ischemic brain lesion was observed in 4 (8%) out of 48 and 10 (8%) out of 127 patients, respectively (p > 0.99). Presence of silent ischemic brain lesions was related to age (p = 0.03) but not to AF pattern (p = 0.77). At least one cerebral microbleed was detected in 5 (13%) out of 30 AF patients without stroke risk factors and 25 (25%) out of 108 AF patients with stroke risk factors (p = 0.2). Presence of cerebral microbleeds was related to male sex (p = 0.04) or peripheral artery occlusive disease (p = 0.03).
Conclusion
In patients with symptomatic AF scheduled for ablation, brain MRI detected silent ischemic brain lesions in approximately one in 12 patients, and microbleeds in one in 5 patients. The prevalence of silent ischemic brain lesions did not differ in AF patients with or without further stroke risk factors.
Circulating MACC1 transcripts in glioblastoma patients predict prognosis and treatment response
(2019)
Glioblastoma multiforme is the most aggressive primary brain tumor of adults, but lacksreliable and liquid biomarkers. We evaluated circulating plasma transcripts of metastasis-associatedin colon cancer-1 (MACC1), a prognostic biomarker for solid cancer entities, for prediction of clinicaloutcome and therapy response in glioblastomas. MACC1 transcripts were significantly higher inpatients compared to controls. Low MACC1 levels clustered together with other prognosticallyfavorable markers. It was associated with patients’ prognosis in conjunction with the isocitratedehydrogenase (IDH) mutation status: IDH1 R132H mutation and low MACC1 was most favorable(median overall survival (OS) not yet reached), IDH1 wildtype and high MACC1 was worst (medianOS 8.1 months), while IDH1 wildtype and low MACC1 was intermediate (median OS 9.1 months).No patients displayed IDH1 R132H mutation and high MACC1. Patients with low MACC1 levelsreceiving standard therapy survived longer (median OS 22.6 months) than patients with high MACC1levels (median OS 8.1 months). Patients not receiving the standard regimen showed the worstprognosis, independent of MACC1 levels (low: 6.8 months, high: 4.4 months). Addition of circulatingMACC1 transcript levels to the existing prognostic workup may improve the accuracy of outcomeprediction and help define more precise risk categories of glioblastoma patients.
TRAF2 controls death receptor-induced caspase-8 processing and facilitates proinflammatory signaling
(2019)
Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) knockout (KO) cells were generated to investigate the role of TRAF2 in signaling by TNFR1 and the CD95-type death receptors (DRs) TRAILR1/2 and CD95. To prevent negative selection effects arising from the increased cell death sensitivity of TRAF2-deficient cells, cell lines were used for the generation of the TRAF2 KO variants that were protected from DR-induced apoptosis downstream of caspase-8 activation. As already described in the literature, TRAF2 KO cells displayed enhanced constitutive alternative NFκB signaling and reduced TNFR1-induced activation of the classical NFκB pathway. There was furthermore a significant but only partial reduction in CD95-type DR-induced upregulation of the proinflammatory NFκB-regulated cytokine interleukin-8 (IL8), which could be reversed by reexpression of TRAF2. In contrast, expression of the TRAF2-related TRAF1 protein failed to functionally restore TRAF2 deficiency. TRAF2 deficiency resulted furthermore in enhanced procaspase-8 processing by DRs, but this surprisingly came along with a reduction in net caspase-8 activity. In sum, our data argue for (i) a non-obligate promoting function of TRAF2 in proinflammatory DR signaling and (ii) a yet unrecognized stabilizing effect of TRAF2 on caspase-8 activity.
BACKGROUND: The barrier to diffusion of organic solutes across the plant cuticle is composed of waxes consisting of very long-chain aliphatic (VLCA) and, to varying degrees, cyclic compounds like pentacyclic triterpenoids. The roles of both fractions in controlling cuticular penetration by organic solutes, e.g. the active ingredients (AI) of pesticides, are unknown to date. We studied thepermeabilityof isolated leaf cuticularmembranes from Garcinia xanthochymus andPrunus laurocerasus for lipophilic azoxystrobin and theobromine as model compounds for hydrophilic AIs.
RESULTS: The wax of P. laurocerasus consists of VLCA (12%) and cyclic compounds (88%), whereas VLCAs make up 97% of the wax of G. xanthochymus.We showthat treating isolated cuticles with methanol almost quantitatively releases the cyclic fraction while leaving the VLCA fraction essentially intact. All VLCAs were subsequently removed using chloroform. In both species, the permeance of the two model compounds did not change significantly after methanol treatment, whereas chloroform extraction had a large effect on organic solute permeability.
CONCLUSION: The VLCA wax fractionmakes up the permeability barrier for organic solutes, whereas cyclic compounds even in high amounts have a negligible role. This is of significance when optimizing the foliar uptake of pesticides.
Macrophages stand in the first line of defense against a variety of pathogens but are also involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages sense a broad range of pathogen- and damage-associated molecular patterns (PAMPs/DAMPs) by plasma membrane and intracellular pattern recognition receptors (PRRs). Intriguingly, the overwhelming majority of PPRs trigger the production of the pleiotropic cytokine tumor necrosis factor-alpha (TNF). TNF affects almost any type of cell including macrophages themselves. TNF promotes the inflammatory activity of macrophages but also controls macrophage survival and death. TNF exerts its activities by stimulation of two different types of receptors, TNF receptor-1 (TNFR1) and TNFR2, which are both expressed by macrophages. The two TNF receptor types trigger distinct and common signaling pathways that can work in an interconnected manner. Based on a brief general description of major TNF receptor-associated signaling pathways, we focus in this review on research of recent years that revealed insights into the molecular mechanisms how the TNFR1-TNFR2 signaling network controls the life and death balance of macrophages. In particular, we discuss how the TNFR1-TNFR2 signaling network is integrated into PRR signaling.
In the present study, LC-HRESIMS-assisted dereplication along with bioactivity-guided isolation led to targeting two brominated oxindole alkaloids (compounds 1 and 2) which probably play a key role in the previously reported antibacterial, antibiofilm, and cytotoxicity of Callyspongia siphonella crude extracts. Both metabolites showed potent antibacterial activity against Gram-positive bacteria, Staphylococcus aureus (minimum inhibitory concentration (MIC) = 8 and 4 µg/mL) and Bacillus subtilis (MIC = 16 and 4 µg/mL), respectively. Furthermore, they displayed moderate biofilm inhibitory activity in Pseudomonas aeruginosa (49.32% and 41.76% inhibition, respectively), and moderate in vitro antitrypanosomal activity (13.47 and 10.27 µM, respectively). In addition, they revealed a strong cytotoxic effect toward different human cancer cell lines, supposedly through induction of necrosis. This study sheds light on the possible role of these metabolites (compounds 1 and 2) in keeping fouling organisms away from the sponge outer surface, and the possible applications of these defensive molecules in the development of new anti-infective agents.
We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific adaptations and unique features of this iconic species, in particular it’s large size and fast growth. Genome sequences from both sexes combined with RAD-tag analyses from other males and females led to the isolation of male-specific scaffolds and supports an XY sex determination system in arapaima. Whole transcriptome sequencing showed that the product of the gland-like secretory organ on the head surface of males and females may not only provide nutritional fluid for sex-unbiased parental care, but that the organ itself has a more specific function in males, which engage more in parental care.
In recent years, the midlatitudes are characterized by more intense heatwaves in summer and sometimes severe cold spells in winter that might emanate from changes in atmospheric circulation, including synoptic‐scale and planetary wave activity in the midlatitudes. In this study, we investigate the heat and momentum exchange between the mean flow and atmospheric waves in the North Atlantic sector and adjacent continents by means of the physically consistent Eliassen–Palm flux diagnostics applied to reanalysis and forced climate model data. In the long‐term mean, momentum is transferred from the mean flow to atmospheric waves in the northwest Atlantic region, where cyclogenesis prevails. Further downstream over Europe, eddy fluxes return momentum to the mean flow, sustaining the jet stream against friction. A global climate model is able to reproduce this pattern with high accuracy. Atmospheric variability related to atmospheric wave activity is much more expressed at the intraseasonal rather than the interannual time‐scale. Over the last 40 years, reanalyses reveal a northward shift of the jet stream and a weakening of intraseasonal weather variability related to synoptic‐scale and planetary wave activity. This pertains to the winter and summer seasons, especially over central Europe, and correlates with changes in the North Atlantic Oscillation as well as regional temperature and precipitation. A very similar phenomenon is found in a climate model simulation with business‐as‐usual scenario, suggesting an anthropogenic trigger in the weakening of intraseasonal weather variability in the midlatitudes.
Protein-protein interaction (PPI) studies are gaining momentum these days due to the plethora of various high-throughput experimental methods available for detecting PPIs. Proteins create complexes and networks by functioning in harmony with other proteins and here in silico network biology hold the promise to reveal new functionality of genes as it is very difficult and laborious to carry out experimental high-throughput genetic screens in living organisms. We demonstrate this approach by computationally screening C. elegans conserved homologs of already reported human tumor suppressor and aging associated genes. We select by this nhr-6, vab-3 and gst-23 as predicted longevity genes for RNAi screen. The RNAi results demonstrated the pro-longevity effect of these genes. Nuclear hormone receptor nhr-6 RNAi inhibition resulted in a C. elegans phenotype of 23.46% lifespan reduction. Moreover, we show that nhr-6 regulates oxidative stress resistance in worms and does not affect the feeding behavior of worms. These findings imply the potential of nhr-6 as a common therapeutic target for aging and cancer ailments, stressing the power of in silico PPI network analysis coupled with RNAi screens to describe gene function.
Polygonum cuspidatum (Japanese knotweed, also known as Huzhang in Chinese), a plant that produces bioactive components such as stilbenes and quinones, has long been recognized as important in traditional Chinese herbal medicine. To better understand the biological features of this plant and to gain genetic insight into the biosynthesis of its natural products, we assembled a draft genome of P. cuspidatum using Illumina sequencing technology. The draft genome is ca. 2.56 Gb long, with 71.54% of the genome annotated as transposable elements. Integrated gene prediction suggested that the P. cuspidatum genome encodes 55,075 functional genes, including 6,776 gene families that are conserved in the five eudicot species examined and 2,386 that are unique to P. cuspidatum. Among the functional genes identified, 4,753 are predicted to encode transcription factors. We traced the gene duplication history of P. cuspidatum and determined that it has undergone two whole-genome duplication events about 65 and 6.6 million years ago. Roots are considered the primary medicinal tissue, and transcriptome analysis identified 2,173 genes that were expressed at higher levels in roots compared to aboveground tissues. Detailed phylogenetic analysis demonstrated expansion of the gene family encoding stilbene synthase and chalcone synthase enzymes in the phenylpropanoid metabolic pathway, which is associated with the biosynthesis of resveratrol, a pharmacologically important stilbene. Analysis of the draft genome identified 7 abscisic acid and water deficit stress-induced protein-coding genes and 14 cysteine-rich transmembrane module genes predicted to be involved in stress responses. The draft de novo genome assembly produced in this study represents a valuable resource for the molecular characterization of medicinal compounds in P. cuspidatum, the improvement of this important medicinal plant, and the exploration of its abiotic stress resistance.
Quinolone antibiotics present an attractive oral treatment option in patients with cystic fibrosis (CF). Prior studies have reported comparable clearances and volumes of distribution in patients with CF and healthy volunteers for primarily renally cleared quinolones. We aimed to provide the first pharmacokinetic comparison for pefloxacin as a predominantly nonrenally cleared quinolone and its two metabolites between both subject groups. Eight patients with CF (fat-free mass [FFM]: 36.3 ± 6.9 kg, average ± SD) and ten healthy volunteers (FFM: 51.7 ± 9.9 kg) received 400 mg pefloxacin as a 30 min intravenous infusion and orally in a randomized, two-way crossover study. All plasma and urine data were simultaneously modelled. Bioavailability was complete in both subject groups. Pefloxacin excretion into urine was approximately 74% higher in patients with CF compared to that in healthy volunteers, whereas the urinary excretion of metabolites was only slightly higher in patients with CF. After accounting for body size and composition via allometric scaling by FFM, pharmacokinetic parameter estimates in patients with CF divided by those in healthy volunteers were 0.912 for total clearance, 0.861 for nonrenal clearance, 1.53 for renal clearance, and 0.916 for volume of distribution. Nonrenal clearance accounted for approximately 90% of total pefloxacin clearance. Overall, bioavailability and disposition were comparable between both subject groups.
Eugenol is a phytochemical present in different plant products, e.g., clove oil. Traditionally, it is used against a number of different disorders and it was suggested to have anticancer activity. In this study, the activity of eugenol was evaluated in a human cervical cancer (HeLa) cell line and cell proliferation was examined after treatment with various concentrations of eugenol and different treatment durations. Cytotoxicity was tested using lactate dehydrogenase (LDH) enzyme leakage. In order to assess eugenol’s potential to act synergistically with chemotherapy and radiotherapy, cell survival was calculated after eugenol treatment in combination with cisplatin and X-rays. To elucidate its mechanism of action, caspase-3 activity was analyzed and the expression of various genes and proteins was checked by RT-PCR and western blot analyses. Eugenol clearly decreased the proliferation rate and increased LDH release in a concentration- and time-dependent manner. It showed synergistic effects with cisplatin and X-rays. Eugenol increased caspase-3 activity and the expression of Bax, cytochrome c (Cyt-c), caspase-3, and caspase-9 and decreased the expression of B-cell lymphoma (Bcl)-2, cyclooxygenase-2 (Cox-2), and interleukin-1 beta (IL-1β) indicating that eugenol mainly induced cell death by apoptosis. In conclusion, eugenol showed antiproliferative and cytotoxic effects via apoptosis and also synergism with cisplatin and ionizing radiation in the human cervical cancer cell line.