Refine
Year of publication
- 2015 (897) (remove)
Document Type
- Journal article (447)
- Doctoral Thesis (344)
- Complete part of issue (50)
- Book article / Book chapter (23)
- Review (7)
- Conference Proceeding (6)
- Working Paper (6)
- Book (5)
- Report (3)
- Jahresbericht (2)
Keywords
- Universität (47)
- University (46)
- Wuerzburg (46)
- Wurzburg (46)
- Würzburg (46)
- expression (19)
- ATLAS detector (18)
- proton-proton collision (13)
- cancer (11)
- in vitro (11)
- therapy (11)
- Higgs boson (10)
- Kernspintomografie (10)
- endothelial cells (9)
- infection (9)
- physics (9)
- Topologischer Isolator (8)
- gene expression (8)
- inflammation (8)
- Aspergillus fumigatus (7)
- Drosophila (7)
- Exziton (7)
- Kohlenstoff-Nanoröhre (7)
- Rezension (7)
- Taufliege (7)
- activation (7)
- antibodies (7)
- gene (7)
- management (7)
- multiple sclerosis (7)
- apoptosis (6)
- blood (6)
- cells (6)
- diagnosis (6)
- guidelines (6)
- membrane proteins (6)
- mice (6)
- mortality (6)
- resistance (6)
- EEG (5)
- P300 (5)
- Therapie (5)
- behavior (5)
- biodiversity (5)
- children (5)
- depression (5)
- disease (5)
- identification (5)
- metaanalysis (5)
- rat (5)
- states (5)
- survival (5)
- Candida albicans (4)
- DNA methylation (4)
- EMG (4)
- Festkörperphysik (4)
- Fluoreszenz (4)
- Immunsuppression (4)
- Krebs <Medizin> (4)
- LHC (4)
- Lunge (4)
- Photolumineszenz (4)
- Photolumineszenzspektroskopie (4)
- Quecksilbertellurid (4)
- Religion (4)
- Selbstorganisation (4)
- Serotonin (4)
- West Africa (4)
- autoimmunity (4)
- blood-brain barrier (4)
- central nervous system (4)
- climate change (4)
- communication (4)
- complex (4)
- energy (4)
- follow-up (4)
- impact (4)
- in vivo (4)
- inhibition (4)
- macrophages (4)
- mechanisms (4)
- metabolism (4)
- model (4)
- mouse model (4)
- mouse models (4)
- multicenter (4)
- multiple myeloma (4)
- nitric oxide (4)
- organic semiconductors (4)
- oxidative stress (4)
- phosphorylation (4)
- positron emission tomography (4)
- proteins (4)
- radiotherapy (4)
- randomized controlled trial (4)
- schizophrenia (4)
- topological insulators (4)
- virulence (4)
- ATLAS (3)
- Angiogenese (3)
- B cells (3)
- Biologische Uhr (3)
- DNA damage (3)
- Dendritische Zelle (3)
- Diamant (3)
- Drosophila melanogaster (3)
- ELISPOT (3)
- Elektronischer Transport (3)
- Entzündung (3)
- Ereigniskorreliertes Potenzial (3)
- Femtosekundenspektroskopie (3)
- Fluoreszenzmikroskopie (3)
- HIV (3)
- HgTe (3)
- Inhibitor (3)
- Ionic Liquids (3)
- Klausur (3)
- Ladungstransfer (3)
- Lanthanoide (3)
- Literatur (3)
- Maus (3)
- Molekularbiologie (3)
- Molekulardynamik (3)
- Myc (3)
- Nanopartikel (3)
- Pharmakokinetik (3)
- Pump-Probe-Technik (3)
- RNA-Seq (3)
- Regulation (3)
- Sprachwissenschaft (3)
- Stammzelle (3)
- Staphylococcus aureus (3)
- Stress (3)
- Supramolekulare Chemie (3)
- T cells (3)
- T-Lymphozyt (3)
- Ultrakurzzeitspektroskopie (3)
- Universität Würzburg (3)
- Vaccinia-Virus (3)
- W boson (3)
- Wirkstoff (3)
- Z boson (3)
- Zellkultur (3)
- active zone (3)
- acute ischemic stroke (3)
- angiogenesis (3)
- anxiety (3)
- association (3)
- attention (3)
- autophagy (3)
- binding (3)
- binding analysis (3)
- biomarkers (3)
- brain (3)
- brain-computer interface (3)
- breast cancer (3)
- cell wall (3)
- charge transfer (3)
- chronic kidney disease (3)
- classification (3)
- crystal structure (3)
- cytotoxicity (3)
- decay (3)
- dendritic cells (3)
- differentiation (3)
- drug (3)
- dynamics (3)
- ecosystem services (3)
- emission (3)
- epidemiology (3)
- epithelial cells (3)
- escherichia coli (3)
- evolution (3)
- experimental autoimmune encephalomyelitis (3)
- exposure (3)
- fear (3)
- fluorescence microscopy (3)
- generation (3)
- glioblastoma multiforme (3)
- growth (3)
- heart (3)
- honeybee (3)
- involvement (3)
- learning and memory (3)
- lesions (3)
- luminescence (3)
- melanoma (3)
- memory (3)
- mesenchymal stem cells (3)
- mitochondria (3)
- models (3)
- mushroom body (3)
- mutations (3)
- near-infrared spectroscopy (3)
- nervous system (3)
- olfaction (3)
- outcomes (3)
- perception (3)
- performance (3)
- permeability (3)
- polymorphism (3)
- proteomics (3)
- radiosensitivity (3)
- regulation (3)
- regulatory T cells (3)
- remote sensing (3)
- reveals (3)
- risk (3)
- risk factors (3)
- safety (3)
- scale (3)
- schistosomiasis (3)
- sepsis (3)
- stem-cell transplantation (3)
- stroke (3)
- synaptic plasticity (3)
- tight junctions (3)
- transcriptome (3)
- trial (3)
- water (3)
- 53BP1 (2)
- ADHS (2)
- ALS (2)
- ARPES (2)
- Ackerschmalwand (2)
- Adhäsion (2)
- Aggregation (2)
- Amphiphile Verbindungen (2)
- Amyotrophe Lateralsklerose (2)
- Analyse (2)
- Angst (2)
- Angststörung (2)
- Antigen CD8 (2)
- Apoptose (2)
- Arabidopsis thaliana (2)
- Arthrose (2)
- Arzneimittel (2)
- Aspergillose (2)
- Atemwegsinfektion (2)
- Atherosklerose (2)
- Aufmerksamkeit (2)
- Autoimmunität (2)
- B-lymphocytes (2)
- BCI (2)
- BNIP3 (2)
- Bacillus subtilis (2)
- Bakterielle Infektion (2)
- Bayern (2)
- Biene (2)
- Biophysik (2)
- Bioverfügbarkeit (2)
- Borylene (2)
- Borylkomplexe (2)
- Brain-computer interface (2)
- Burkina Faso (2)
- C60 (2)
- CD1d (2)
- CD8 (2)
- CXCR4 (2)
- Charcot-Marie-Tooth (2)
- Chemotherapie (2)
- Chiralität <Chemie> (2)
- Chlamydia trachomatis (2)
- Cryptochrom (2)
- DNA double strand breaks (2)
- DNA repair (2)
- Data Mining (2)
- Degradation (2)
- Diffusion (2)
- Digital Humanities (2)
- Diindenoperylen (2)
- Early Basso Continuo (2)
- Early Music (2)
- Echinococcus (2)
- Einzelhandel (2)
- Elektronentransfer (2)
- Energietransfer (2)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (2)
- Epigenetik (2)
- Evaluation (2)
- Fabry disease (2)
- Fc-receptor (2)
- Fettgewebsstammzellen (2)
- Finanzmathematik (2)
- Flugkörper (2)
- Fotoionisation (2)
- Frankreich (2)
- Fuchsbandwurm (2)
- Furcht (2)
- Gehirn-Computer-Schnittstelle (2)
- Gewebe (2)
- Gitterbaufehler (2)
- Glioblastom (2)
- Glucosetransportproteine (2)
- Hippocampus (2)
- Humangenetik (2)
- Immunsystem (2)
- Implantat (2)
- Inhibition (2)
- Inklusion (2)
- Insulin-like Growth Factor I (2)
- Intensivstation (2)
- Invasive Aspergillose (2)
- Jahresbericht (2)
- Kaliumkanal (2)
- Klimaänderung (2)
- Kognition (2)
- Konditionierung (2)
- Kondo-Effekt (2)
- Kontrollierte Wirkstofffreisetzung (2)
- Kooperativität (2)
- Koordinationspolymere (2)
- LASP-1 (2)
- LASP1 (2)
- LC-MS/MS (2)
- LMHFV (2)
- Leishmaniose (2)
- Linguistik (2)
- Löslichkeit (2)
- Magnetische Kernresonanz (2)
- Magnetresonanztomographie (2)
- Maschinelles Lernen (2)
- Medulloblastom (2)
- Medulloblastoma (2)
- Melanom (2)
- Mesenchymzelle (2)
- Metastase (2)
- Microarray (2)
- Multiples Myelom (2)
- Myatrophische Lateralsklerose (2)
- Mycobacterium (2)
- NVP-BEZ235 (2)
- Netzwerk (2)
- Nozizeptor (2)
- Optimale Kontrolle (2)
- Organische Solarzelle (2)
- Osteoarthritis (2)
- Parkinson-Krankheit (2)
- Performance practice (2)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (2)
- Perylenbisimid (2)
- Photoelektronenspektroskopie (2)
- Prognose (2)
- Pyrolyse (2)
- RIXS (2)
- RNAi (2)
- RS-Virus (2)
- Rashba-Effekt (2)
- Rastertunnelmikroskop (2)
- Ratte (2)
- Regeneration (2)
- Regionalentwicklung (2)
- Repräsentation (2)
- Rezeption (2)
- Rezeptor (2)
- Rhodopsin (2)
- Roman (2)
- Romanistik (2)
- Sahel (2)
- Schizophrenie (2)
- Schlaganfall (2)
- Schule (2)
- Sekundarstufe (2)
- Signalkette (2)
- Silicium (2)
- Siliciumcarbid (2)
- Siliciumorganische Verbindungen (2)
- Spintronik (2)
- Stammzelltransplantation (2)
- Strukturaufklärung (2)
- Supersymmetrie (2)
- Supersymmetry (2)
- Syntax (2)
- Systemisches Risiko (2)
- T lymphocytes (2)
- TAVI (2)
- TGF-beta (2)
- TRAF2 (2)
- TWEAK (2)
- Theoretische Chemie (2)
- Transiente Absorptionsspektroskopie (2)
- Transkription <Genetik> (2)
- Tuberkelbakterium (2)
- UAV (2)
- Ultraschnelle Photochemie (2)
- Ultraviolett-Photoelektronenspektroskopie (2)
- Unternehmen (2)
- Valenz <Linguistik> (2)
- Virtualisierung (2)
- Wettbewerb (2)
- Wirkstofffreisetzung (2)
- absorption (2)
- adaptive immune system (2)
- adenocarcinoma (2)
- adults (2)
- aggregation (2)
- aging (2)
- anatomy (2)
- antibiotic resistance (2)
- antileishmanial (2)
- atherosclerosis (2)
- avoidance learning (2)
- bees (2)
- biodiversity conservation (2)
- biofilm formation (2)
- biofilms (2)
- biomarker (2)
- bone disease (2)
- bumblebees (2)
- butterflies (2)
- cardiovascular (2)
- cardiovascular disease (2)
- cell membranes (2)
- cell proliferation (2)
- cell staining (2)
- chemokine receptor (2)
- chlamydia (2)
- chronic stress (2)
- competition (2)
- complement (2)
- conservation (2)
- convection volume (2)
- coordination polymers (2)
- cytokinesis (2)
- cytoskeleton (2)
- dSTORM (2)
- deficiency (2)
- degradation (2)
- demyelination (2)
- development (2)
- diabetes mellitus (2)
- disability (2)
- domain (2)
- down regulation (2)
- drug metabolism (2)
- echocardiography (2)
- ecology (2)
- electronic structure (2)
- embodied cognition (2)
- emotion (2)
- emotional facial expressions (2)
- energy transfer (2)
- enzyme-linked immunoassays (2)
- event-related potentials (2)
- excitations (2)
- experience (2)
- facial expressions (2)
- fibrosis (2)
- fluorescence (2)
- fluorescent probes (2)
- food (2)
- food security (2)
- fracture healing (2)
- gastric cancer (2)
- gender (2)
- genetics (2)
- genome sequence (2)
- genome-wide association (2)
- glaucoma surgery (2)
- glucocorticoids (2)
- géochimie (2)
- habitats (2)
- heart failure (2)
- histone H2AX (2)
- human african trypanosomiasis (2)
- human brain (2)
- immune response (2)
- immunotherapy (2)
- in vivo imaging (2)
- incidence (2)
- innate immunity (2)
- insects (2)
- insulator (2)
- insulin resistance (2)
- interband cascade lasers (2)
- interface (2)
- interval timing (2)
- intuition (2)
- invasive pulmonary aspergillosis (2)
- ion channels (2)
- ischemic stroke (2)
- kidneys (2)
- leaf-cutting ants (2)
- leishmania major (2)
- lines (2)
- lipids (2)
- localization microscopy (2)
- lymphoma (2)
- magnetic resonance imaging (2)
- malaria (2)
- mast cells (2)
- melanoma cells (2)
- messenger RNA (2)
- microarray (2)
- microenvironment (2)
- microglomeruli (2)
- micronucleus test (2)
- microscopie (2)
- microstratigraphie (2)
- minéralogie (2)
- modulation (2)
- molecular dynamics (2)
- molecular imaging (2)
- monocytes (2)
- motor proteins (2)
- mycobacterium tuberculosis (2)
- myocardial infarction (2)
- nerve fibers (2)
- neuromuscular junction (2)
- neuronal differentiation (2)
- neuropathic pain (2)
- neurotransmitter release (2)
- neurotrophic factor (2)
- next generation sequencing (2)
- oestrogen receptor signalling (2)
- oral bioavailability (2)
- organische Halbleiter (2)
- pathogenicity (2)
- pathway (2)
- pathways (2)
- phasic affective modulation (2)
- plasmodium falciparum (2)
- polarization (2)
- postnatal development (2)
- pregnancy (2)
- prevalence (2)
- processing fluency (2)
- prognostic value (2)
- protein (2)
- protein kinase (2)
- protein-coupled receptors (2)
- proton-proton-collision (2)
- proton–proton collisions (2)
- psychiatric disorders (2)
- pulmonal (2)
- radioiodine therapy (2)
- reaktive Intermediate (2)
- receptor beta (2)
- receptors (2)
- recommendations (2)
- repair (2)
- replacement (2)
- reporter gene (2)
- rolipram (2)
- semantic coherence (2)
- sensory neurons (2)
- serum (2)
- sex chromosome evolution (2)
- sizing (2)
- skin (2)
- smoking (2)
- snoRNA (2)
- spin (2)
- startle (2)
- startle reflex (2)
- structure-function relationships (2)
- subthalamic nucleus (2)
- subventricular zone (2)
- super-resolution microscopy (2)
- suppressor cells (2)
- surgery (2)
- susceptibility (2)
- synthetic aperture radar (2)
- system (2)
- taxonomy (2)
- temperature (2)
- tissue engineering (2)
- topological insulator (2)
- transcription (2)
- transcription factors (2)
- traumatic brain injury (2)
- treatment (2)
- tumor (2)
- tumor immunity (2)
- tumor-infiltrating lymphocytes (2)
- tumors (2)
- type 2 diabetes (2)
- ultrafast photochemistry (2)
- unpleasant pictures (2)
- vacancy (2)
- vaccine (2)
- vaccinia virus (2)
- validation (2)
- variants (2)
- virotherapy (2)
- "-omics" (1)
- (+)-limonene (1)
- (6,5) carbon nanotubes (1)
- (6,5)-Kohlenstoffnanoröhre (1)
- (6,5)-Kohlenstoffnanoröhren (1)
- (bi)pyridine-based ligand (1)
- 1,25-dihydroxyvitamin D\(_{3}\) (1)
- 131-I Ablation (1)
- 131-I ablation (1)
- 1550 nm (1)
- 1680 (1)
- 19F MR (1)
- 1st International Workshop (1)
- 2-APB (1)
- 2-dimensional speckle tracking (1)
- 2-pore potassium channel (1)
- 2015 (1)
- 2B (1)
- 3 Tesla (1)
- 3-D liver model (1)
- 3-dimensional structure (1)
- 3-dimensional visualization (1)
- 3D Printing (1)
- 3D printing (1)
- 3D topological insulator (1)
- 3D-Druck (1)
- 4'-hydroxylation (1)
- 4D (1)
- 4H (1)
- 5-HTT (1)
- A(2B) receptors (1)
- A-priori-Wissen (1)
- AAC (1)
- ABA receptors (1)
- AC Gradients (1)
- ACP5 (1)
- ADMA/ADMA (1)
- ADP-Rezeptor (1)
- AGB (1)
- AIDS (1)
- AIM2 (1)
- AKT1-like (1)
- AMIS (1)
- AMIS, Direct anterior approach, hip arthroplasty, stepwatch, comparison (1)
- ANOVA (1)
- ARDS (1)
- AS clavicle plate (1)
- ASAR (1)
- ASAXS (1)
- ASC (1)
- ATLAS <Teilchendetektor> (1)
- ATLAS-Detektor (1)
- AZD6244 (1)
- AZO (1)
- Abschattung (1)
- Abscisinsäure (1)
- Absorptionsspektroskopie (1)
- Abstimmbarer Laser (1)
- Abtragung (1)
- Abtreibung (1)
- Abwägung (1)
- Acromesomelic dysplasias (1)
- Acromyrmex ambiguus (1)
- Actin (1)
- Actinoide (1)
- Active pharmaceutical ingredients (1)
- Acute Kidney Injury (1)
- Acyrthosiphon pisum (1)
- Adaptives Immunsystem (1)
- Adenokarzinom (1)
- Adenosin (1)
- Adenosine receptors (1)
- Adenosinrezeptor (1)
- Adenoviren (1)
- Adipogenesis (1)
- Adipositas (1)
- Adsorption (1)
- Advanced Driver Assistance Systems (1)
- Affekt (1)
- Africa (1)
- Afrika (1)
- Agglomerationseffekt (1)
- Aggregat <Chemie> (1)
- Agrarproduktion (1)
- Akt (1)
- Aktiv (1)
- Aktiv-kontrollierten Bewegungsschiene (1)
- Aktive Sicherheit (1)
- Aktivierung <Chemie> (1)
- Akustischer Startle Reflex (1)
- Akutes Nierenversagen (1)
- Algerien (1)
- Algerienkrieg (1)
- Algorithms (1)
- Algorithmus (1)
- Alkoholabhängigkeit (1)
- Alkylidenboryl komplexe (1)
- Allgemeine Geschäftsbedingungen (1)
- Alpha Neurofeedback (1)
- Alter (1)
- Alzheimer disease (1)
- Alzheimer`s disease (1)
- Alzheimerkrankheit (1)
- American Association of Oral and Maxillofacial Surgeons (1)
- Aminosäuren (1)
- Amor-Lauden (1)
- Amphibia (1)
- Analytic Hierarchy Process (1)
- Analytik (1)
- Ancistrocladaceae (1)
- Ancistrocladus (1)
- Angabe (1)
- Angeregter Zustand (1)
- Angiogenesis (1)
- Animal studies (1)
- Annual report (1)
- Annäherung-Vermeidung (1)
- Anpassungstest (1)
- Anreizsystem (1)
- Anteriorer Cingulärer Kortex (1)
- Antibiotikatherapie (1)
- Antibiotikum (1)
- Antigen CD40 (1)
- Antikenrezeption (1)
- Antikörper (1)
- Antimykotikum (1)
- Antitumorale Wirkstoffe (1)
- Anton Ulrich, Braunschweig-Lüneburg, Herzog (1)
- Anton Ulrich, Braunschweig-Lüneburg, Herzog / Octavia (1)
- Anura (1)
- Anwenderschulung (1)
- Anxiety Disorders (1)
- Apallisches Syndrom (1)
- Apoptosis (1)
- App (1)
- Application-Aware Resource Management (1)
- Approach-Avoidance (1)
- Approach-Avoidance-Task (1)
- Arachidonsäure (1)
- Arbeit (1)
- Arbeitsgedächtnis (1)
- Arbeitsteilung (1)
- Arcipreste de Hita (1)
- Arctic (1)
- Argumentation (1)
- Artefakt <Bildgebende Diagnostik> (1)
- Arteriosklerose (1)
- Arthrodese (1)
- Arthrodesis (1)
- Arthroleptis amphibia (1)
- Arthroplastik (1)
- Arthrosis deformans (1)
- Arzneimitteldesign (1)
- Arzneimittelforschung (1)
- Arzneimittelmarkt (1)
- Arzneimittelsicherheit (1)
- Asien (1)
- Aspergillus (1)
- Assembly (1)
- Assistierte Beatmung (1)
- Assoziatives Gedächtnis (1)
- Astrozyten (1)
- Atemwegserkrankung (1)
- Athlet/in (1)
- Au/Ge(111) (1)
- Audit sampling (1)
- Augenheilkunde (1)
- Augustin (1)
- Aurora-A (1)
- Ausbreitung (1)
- Australian stingless bees (1)
- Autoimmunity (1)
- Automobilzulieferer (1)
- Autophagie (1)
- Autophagiescore (1)
- Aversive Konditionierung (1)
- Avidität (1)
- Axonal degeneration (1)
- Aδ- and C-fibers (1)
- B-Lymphocyten (1)
- B-Lymphozyt (1)
- B-MYB (1)
- B-Zelle (1)
- B-cell lymphoma (1)
- B1 Mapping (1)
- B7-H1 (1)
- BH3 domains (1)
- BMPR1B (1)
- BMS-5 (1)
- BRAF(V600E) mutation (1)
- BRICS-Staaten (1)
- BSM Higgs boson (1)
- BV-2 (1)
- BaPb\(_{1-X}\)Bi\(_{X}\)O\(_{3}\) (1)
- Bacillus-Calmette-Guerin (1)
- Banks Islands (1)
- Bariatric surgery (1)
- Barrett-Karzinom (1)
- Barrierefreiheit (1)
- Bathophenanthrolin (1)
- Bauchspeicheldrüsenkrebs (1)
- Baudelaire, Charles (1)
- Bavaria (1)
- Bcl-2 proteins (1)
- Beamtenrecht (1)
- Behandlung (1)
- Behandlungsoption (1)
- Belastung (1)
- Benin (1)
- Benn, Gottfried (1)
- Benutzerfreundlichkeit (1)
- Benutzerfreundlichkeit/ Benutzbarkeit (1)
- Benzodiazepine (1)
- Bericht (1)
- Berufskolleg (1)
- Beschichtung (1)
- Beschichtungen (1)
- Beschriftung (1)
- Beschriftung von Straßen (1)
- Besondere Ausgleichsregelung (1)
- Bessle functions (1)
- Betreuungsrecht (1)
- Beverungen (1)
- Bewusstsein (1)
- Bewusstseinsstörung (1)
- Bewusstseinsstörungen (1)
- Beyond Standard Model (1)
- Bienen <Familie> (1)
- Biholomorphe Abbildung (1)
- Bilagen-Solarzelle (1)
- Bildungspolitik (1)
- Binary Decision Diagram (1)
- Bindungsaktivierungsreaktionen (1)
- Binomialverteilung (1)
- BioID (1)
- Biochemie (1)
- Biographieforschung (1)
- Biographisches Interview (1)
- Biological Networks (1)
- Biologie / Zellbiologie (1)
- Biologischer Abbau (1)
- Biomechanik (1)
- Bioorganische Chemie (1)
- Biopsie (1)
- Biosphärenreservat (1)
- Bipolar DGKH-GAT Endophänotypen (1)
- Bliombéris (1)
- Bloch Siegert (1)
- Blockcopolymere (1)
- Blut-Nerven-Schranke (1)
- Bluthochdruck (1)
- Blutzuckerverlauf (1)
- Bodin, Jean (1)
- Bola-Amphiphil (1)
- Bone marrow stromal cell (BMSC) (1)
- Bone morphogenetic protein-2 (1)
- Boner, Hieronymus (1)
- Bor-dotiert (1)
- Borchemie (1)
- Boride (1)
- Boridkomplexe (1)
- Borirene (1)
- Borole (1)
- Borylenkomplexe (1)
- Borylentransfer (1)
- Borylgruppe (1)
- Bose-Einstein Correlations (1)
- Bose-Einstein-Kondensation (1)
- Bovis (1)
- Brain-Computer Interface (BCI) (1)
- BrdU replication banding pattern (1)
- BrdU/dT replication banding (1)
- Breitensport (1)
- Briefwechsel (1)
- Bruchpilot (1)
- Brust (1)
- Bunnell (1)
- Burkitt (1)
- C virus (1)
- C-11-methionine pet (1)
- C-6-H (1)
- C-Myc (1)
- C. elegans (1)
- CB1 receptor antagonists (1)
- CD-Spektroskopie (1)
- CD1c⁺ mDC (1)
- CD28 Superagonist (1)
- CD39 (1)
- CD4 (1)
- CD4 T cells (1)
- CD4+T cells (1)
- CD40 (1)
- CD73 (1)
- CD8 T cell (1)
- CD8 T-Zelle (1)
- CD8+T cells (1)
- CGG repeat (1)
- CHC-Theorie (1)
- CNS disease (1)
- CNS injury (1)
- CNTF (1)
- CO-releasing molecules (1)
- CP-690,550 (1)
- CPG Island (1)
- CQF (1)
- CRP/crp (1)
- CT (1)
- CT Scan (1)
- CTB 109 (1)
- CTL function (1)
- CTSE (1)
- CX3CR1 (1)
- CXCR4/SDF-1 (1)
- CYP induction (1)
- CYP inhibition (1)
- CaMKII (1)
- Ca\(^{2+}\) channels (1)
- Caenorhabditis elegans (1)
- Calciumphosphat (1)
- Carbenkomplexe (1)
- Carbon Nanotube (1)
- Cardiac surgery (1)
- Carrefour (1)
- Cathepsin E (1)
- Caylus (1)
- CePt5 (1)
- Cellular Networks (1)
- Cestoda Taeniidae (1)
- ChAT (1)
- ChIP-sequencing (1)
- ChT1 (1)
- Charakterisierung (1)
- Charcot-Marie-Syndrom (1)
- Chemische Bindung (1)
- Chemische Reinheit (1)
- China (1)
- China Resource (1)
- Chiral-sensitive Specktroskopie (1)
- Chirurgie (1)
- Chirurgisch unterstützte Gaumennahterweiterung - transpalatinaler Distraktor - Hyrax Appartur - dreidimensional - Zahnkippung (1)
- Chlamydia (1)
- Christine de Pizans (1)
- Christine, de Pisan : Le livre de la cité des dames (1)
- Chromatographie (1)
- Chromosomenaberration (1)
- Chromosomenaberrationstest (1)
- Chronische Niereninsuffizienz (1)
- Chronische Schmerzen (1)
- Chronischer Schmerz (1)
- Chronophin (1)
- Chrétien, de Troyes (1)
- Ciliary neurotrophic factor (1)
- Circadian Rhythms (1)
- Circadian clock (1)
- Circadiane Rhythmen (1)
- Claudin (1)
- Clec16a (1)
- Cloud Computing (1)
- Co-option (1)
- Cofilin (1)
- Colloquium heptaplomeres de rerum sublimium arcanis abditis (1)
- Comet Assay (1)
- Common Consolidated Corporate Tax Base (CCCTB) (1)
- Commonwealth (1)
- Comparative politics (1)
- Complex Systems (1)
- Compound eyes (1)
- Compression therapy (1)
- Computational Investigation (1)
- Computational chemistry (1)
- Computational drug-design (1)
- Computer Center University of Wuerzburg (1)
- Computerkartografie (1)
- Computersimulation (1)
- Computertomographie (1)
- Concurrent Systems (1)
- Conflict Monitoring Theorie (1)
- Congo Basin (1)
- Contemporary Philosophy (1)
- Continuous Sample Path (1)
- Controllability (1)
- Controlled release (1)
- Copula (1)
- Copula <Mathematik> (1)
- Cortex (1)
- Costa Rica (1)
- Coulomb interaction (1)
- Counterparty Risk (1)
- CpG island hypermethylation (1)
- Crab-Nebel (1)
- Credibility interval (1)
- Crohn’s disease (1)
- Crossed Andreev Refexion (1)
- Crossed Andreev Reflection (1)
- Cu(111) (1)
- CuPc (1)
- Cultural studies (1)
- Cuscuta (1)
- Cutaneous leishmaniasis (1)
- Cyclo-AMP (1)
- Cynoglossus semilaevis (1)
- Cys-loop receptor (1)
- Cystein (1)
- Cytotoxizität (1)
- Côte d’Ivoire (1)
- D-Norm (1)
- D2 receptors (1)
- D665 (1)
- DC-Gating (1)
- DC/T-Zell-Konjugate (1)
- DMRT1 (1)
- DNA (1)
- DNA Doppelstrangbrüche (1)
- DNA Mismatch repair (1)
- DNA barcoding (1)
- DNA double-strand break (1)
- DNA helicase (1)
- DNA repair defect (1)
- DNA-SWNT hybrids (1)
- DNA-SWNT-Konjugate (1)
- DNA-Sequenz (1)
- DNA-binding proteins (1)
- DNS-Doppelstrangbruch (1)
- DNS-Reparatur (1)
- DREAM (1)
- Dachmarke Rhön (1)
- Dante (1)
- Dante, Alighieri (1)
- Dante, Alighieri : Divina commedia (1)
- Darm (1)
- Darmflora (1)
- Das Konzept der Westernisierung (1)
- Data Modeling (1)
- Datenmodell (1)
- Dativ (1)
- Deeskalation (1)
- Deeskalationstherapie (1)
- Defective Democracy (1)
- Defektspektroskopie (1)
- Dehydrokupplung (1)
- Dekompressionsoperation (1)
- Delphi procedure (1)
- Demenz (1)
- Democracy Measurement (1)
- Democratic People's Republic of Korea (1)
- Demokratie (1)
- Demokratische Republik Kongo (1)
- Demyelinisierung (1)
- Demökologie (1)
- Dendritische Zellen (1)
- Dependenz (1)
- Depression (1)
- Der Spiegel <Zeitschrift> (1)
- Desertifikation (1)
- Design and Development (1)
- Desorption (1)
- Detektor (1)
- Determination of compound purity (1)
- Deutsch-Französischer Krieg <1870-1871> (1)
- Deutsches Papyruskartell (1)
- Deutschland (1)
- Diabetes mellitus (1)
- Diabetes mellitusTyp 1 (1)
- Diabetes melltius (1)
- Diabetic polyneuropathy (1)
- Diagnostik (1)
- Dialektik (1)
- Dianion (1)
- Dickdarmkrebs (1)
- Didaktik (1)
- Differentialgleichung (1)
- Differentiated thyroid carcinoma (1)
- Differentiation (1)
- Digital (1)
- Digital Elevation Model (1)
- Digitale Karte (1)
- Dihydroborane (1)
- Dimension 3 (1)
- Dimensional Crossover (1)
- Dimerisierung (1)
- Dionaea muscipula (1)
- Dipol <1,3-> (1)
- Dipolare Cycloaddition (1)
- Direct anterior approach (1)
- Dirichlet-Reihe (1)
- Diskursanalyse (1)
- Dispergierung (1)
- Dissoziative Photoionisation (1)
- Diversifikation <Biologie> (1)
- Diversity (1)
- Division of labor (1)
- Dixon (1)
- Doctorial Consortium, WI 2015 (1)
- Domänenadaption (1)
- Don Juan (1)
- Donor-Photosensibilisator-Akzeptor Triade (1)
- Dopamin Metabolism (1)
- Dopaminmetabolismus (1)
- Doppelbindung (1)
- Dosimetrie (1)
- Dotierung (1)
- Double Negative B cells (1)
- Drahtloses lokales Netz (1)
- Drainagesystem (1)
- Dreidimensionale Bildverarbeitung (1)
- Dreieck (1)
- Dreifachbindung (1)
- Dresden (1)
- Driver assistance (1)
- Driving simulation (1)
- Druckoptimum (1)
- Drude model (1)
- Drude-Modell (1)
- Drug design (1)
- Dual 3'seq (1)
- Duodenal Jejunal Bypass (1)
- Duplexsonographie (1)
- Dynamic Causal Modeling (1)
- Dynamic representations (1)
- Dynamik (1)
- Dynamische Repräsentation (1)
- Désiré Razafinjato (1)
- Düne (1)
- Dünen (1)
- Dünne Schicht (1)
- Dünnschichtsolarzelle (1)
- EAE (1)
- EDX spectra (1)
- EEG 2014 (1)
- EEG data (1)
- EEG-Umlage (1)
- EEG/ERP (1)
- ELBWI (1)
- ENVISAT ASAR WSM (1)
- EPC (1)
- EQUAL-Pilotstudie (1)
- ERK map kinease (1)
- ERN (1)
- ERPs (Event-Related Potentials) (1)
- ESC (1)
- EU (1)
- EVER1 (1)
- EVER2 (1)
- EZH2 differentiation trichostatin (1)
- Ehre (1)
- Ehre <Motiv> (1)
- Eierstockkrebs (1)
- Eierstocktumor (1)
- Eigenversorger (1)
- Einwandige Kohlenstoff-Nanoröhre (1)
- Einzelstrang-DNA (1)
- Eisen-substituierte Borirene (1)
- Eisenoxidnanopartikel (1)
- El burlador de Sevilla y convidado de piedra (1)
- Elastographie (1)
- Electrochemical energy storage (1)
- Electrospinning (1)
- Elektrochromes Element (1)
- Elektrochromie (1)
- Elektroencephalographie (1)
- Elektrolumineszenz (1)
- Elektrolyse (1)
- Elektronencephalographie (1)
- Elektronendichte (1)
- Elektronenkorrelation (1)
- Elektronenmikroskopie (1)
- Elektronenstruktur (1)
- Elektronische Eigenschaften (1)
- Elektrophysiologie (1)
- Elektrorheologie (1)
- Elemente (1)
- Elliptische Differentialgleichung (1)
- Elongation (Transkription) (1)
- Eltern (1)
- Emerging Power (1)
- Emery Kivelson line (1)
- Empfängnisverhütung (1)
- Encapsulation (1)
- Endogenes Erythropoietin und Mortalität (1)
- Endogenous erythropoietin and all-cause mortality (1)
- Endoprothetik (1)
- Endothel (1)
- Endothelpermeabilität (1)
- Energiespeicher (1)
- Energietransfer <Mikrophysik> (1)
- Englisch (1)
- Enrique Gaspar y Rimbau (1)
- Entzündungschmerz (1)
- Envisat (1)
- Enzymaktivierung (1)
- Enzyme-Linked Immunospot assay (ELISPOT) (1)
- EphA2 (1)
- Ephrin ligand (1)
- Ephrine (1)
- Epigenetic (1)
- Epimutationen (1)
- Erbkrankheit (1)
- Erbrecht (1)
- Erdalkalimetalle (1)
- Ergänzung (1)
- Erholungsplanung (1)
- Erinnerung (1)
- Erinnerungsproblematik (1)
- Erneuerbare-Energien-Gesetz (1)
- Ernährungstherapie (1)
- Erythropoietin (1)
- Escherichia coli (1)
- Escherichia coli AlkA (1)
- Estradiol (1)
- Estradiolkonjugate (1)
- Ethiopia (1)
- Ethylenglykolderivate (1)
- Europarecht (1)
- European Society (1)
- European experts (1)
- Europäische Kommission / Generaldirektion Wettbewerb (1)
- Europäische Union (1)
- Europäischer Gesetzgebungsprozess (1)
- Evans syndrome (1)
- Evaporation-Induced Self-Assembly (1)
- Evolutionärer Algorithmus (1)
- Ewing-Sarkom (1)
- Exact-controllability (1)
- Exciton (1)
- Experimental physics (1)
- Expert System (1)
- Expertensystem (1)
- Exponential smoothing (1)
- Exponential smoothing with covariates (1)
- Extrakt (1)
- Extreme Value Theory (1)
- Extremwertstatistik (1)
- Extremwerttheorie (1)
- Exzerpt (1)
- Exziton-Polariton (1)
- Exzitonen Diffusionslänge (1)
- Exzitonen Dynamik (1)
- Exzitonen Transport (1)
- Exzitonenbeweglichkeit (1)
- Exzitonendynamik (1)
- Exzitonengröße (1)
- Eyjafjallajökull 2010 (1)
- FANCA (1)
- FANCD2 (1)
- FANCO (1)
- FDG (1)
- FDG PET/CT (1)
- FDG-PET/CT (1)
- FDG-PET/MRI (1)
- FISH (1)
- FMMs (1)
- FMR1 (1)
- FMR2 (1)
- FOXM1 (1)
- FTIR spectroscopy (1)
- FTY720-P (1)
- FXR1 (1)
- FXR2 (1)
- FabI (1)
- Fabry-associated pain (1)
- Fachsprache (1)
- Fahrerassistenz (1)
- Fahrerassistenzsystem (1)
- Fahrerinformationen (1)
- Fahrsimulator (1)
- Falle (1)
- Family Investigation of Nephropathy and Diabetes (1)
- Fanconi Anämie (1)
- Fanconi anemia (1)
- Farbstoff (1)
- Fc-Rezeptor (1)
- Fear (1)
- Fear Conditioning (1)
- Fear Extinction (1)
- Fehlerverarbeitungstherorie (1)
- Feldstärkemessung (1)
- Femtochemie (1)
- Femtochemistry (1)
- Femtosecond Spectroscopy (1)
- Femtosekunden Pulsformung (1)
- Femtosekundenbereich (1)
- Femtosekundenlaser (1)
- Fest-Flüssig-Extraktion (1)
- Festphasenextraktion (1)
- Fettgewebe (1)
- Fettsucht (1)
- Fettzelle (1)
- Fibroblastenwachstumsfaktor (1)
- Fibronektin-Bindeprotein (1)
- Fieber (1)
- Figur (1)
- Figurenerkennung (1)
- Figurenrede (1)
- Financial Networks (1)
- Finanzielle Netzwerke (1)
- Finanzverfassung (1)
- Finite-Elemente-Methode (1)
- Firmwert (1)
- Flotillin (1)
- Fluoreszenz-Resonanz-Energie-Transfer (1)
- Fluoreszenzkorrelationsspektroskopie (1)
- Fluoreszenzspektroskopie (1)
- Flächenverbrauch (1)
- Foamyviren (1)
- Fokker-Planck optimality systems (1)
- Fokker-Planck-Gleichung (1)
- Folter (1)
- Force Field (1)
- Formation Flight (1)
- Formmessung (1)
- Fotochemie (1)
- Fotophysik (1)
- Foxp3 (1)
- Fractalkin (1)
- Fragestunde (1)
- Fragmentierung (1)
- Frankfurt am Main (1)
- Frankfurter Passionsspiel (1)
- Französisch (1)
- Französische Feldwespe (1)
- Französische Kulturwissenschaft (1)
- Französische Literatur (1)
- Frau (1)
- Free Energy Perturbation (1987 : Princeton, NJ) (1)
- Freedom House (1)
- Freie Enthalpie (1)
- Freisetzung (1)
- Frühe Neuzeit (1)
- Frühgeborene (1)
- Frühgeburt (1)
- Funktionelle Kernspintomografie (1)
- Funktionswerkstoff (1)
- Furchtkonditionierung (1)
- Future Internet (1)
- Fußball (1)
- Förderschwerpunkt Geistige Entwicklung (1)
- Förderung (1)
- G-Protein gekoppelte Rezeptoren (1)
- G-Protein-gekoppelte Rezeptoren (1)
- G-quadruplex motifs (1)
- GABA(A) receptor (1)
- GABA-Rezeptor (1)
- GAS2L3 (1)
- GBM (1)
- GC-MS (1)
- GDF-15 (1)
- GIS (1)
- GITR (1)
- GPS-Tracking (1)
- GRO alpha (1)
- GSTP1 (1)
- GaAs (1)
- Galabiose (1)
- Gallium (1)
- Galliumarsenid (1)
- Gamma-Konvergenz (1)
- Gammaastronomie (1)
- Gammastrahlenastronomie (1)
- Gaumennahterweiterung (1)
- Gefahrenlernen (1)
- Gefühl (1)
- Gegenwartssprache (1)
- Gehirn-Computer Schnittstelle (1)
- Geistigbehindertenpädagogik (1)
- Gelenkknorpel (1)
- Gelernte Hilflosigkeit (1)
- Gemeinsame Konsolidierte Körperschaftsteuer-Bemessungsgrundlage (GKKB) (1)
- Gen (1)
- Generalized Pareto Distribution (1)
- Generation von 27 (1)
- Generation von 98 (1)
- Genetic engineering (1)
- Genexpression (1)
- Genitiv (1)
- Genotoxizität (1)
- Gentherapie (1)
- Geobotanik (1)
- Geordnetes binäres Entscheidungsdiagramm (1)
- German Stroke Registers Study Group (1)
- Geräuschminderung (1)
- Geschichte (1)
- Geschichte 1495-1806 (1)
- Geschichte 1680 (1)
- Geschichte 1700- (1)
- Geschichte 2012-2014 (1)
- Geschichte 2014 (1)
- Geschichtsschreibung (1)
- Geschlechterforschung (1)
- Geschützte Natur (1)
- Gesellschaftsordnung (1)
- Gesetzgebungsverfahren (1)
- Gewebebindung (1)
- Gewebespende (1)
- Gewebespiegel (1)
- Gewissen <Motiv> (1)
- Gibbs Energy (1)
- Glatter Krallenfrosch (1)
- Glaukom (1)
- Gleichberechtigung (1)
- Gleichrichtung (1)
- Glucocorticoide (1)
- Glucocorticosteroide (1)
- Glucosetransport (1)
- Glucosinolat (1)
- Glycochip (1)
- Goodness-of-Fit Test (1)
- Governance (1)
- Grammatik (1)
- Graphene (1)
- Graphentheorie (1)
- Grebe dysplasia (1)
- Grenzfläche (1)
- Grotte (1)
- Growth (1)
- Growth-differentiation Factor 15 (1)
- Grundfreiheiten (1)
- Grundfrequenz (1)
- Grundschulkind (1)
- Guinean rain forest (1)
- Göttliche Komödie (1)
- H-FABP (1)
- HAK5-like (1)
- HAND (HIV assoziierte neurologische Störungen) (1)
- HCMV infection (1)
- HCV genotype 2 (1)
- HE-3 diffusion MRI (1)
- HEK cells (1)
- HERV (1)
- HES (1)
- HHblits (1)
- HIF-1α (1)
- HIV-1-infected subjects (1)
- HIV-Subtyp (1)
- HIV-infected patients (1)
- HK-2 Zellen (1)
- HKT1-like (1)
- HLA-G (1)
- HLA-G gene (1)
- HPLC (1)
- HPLC method development (1)
- HPLC-CD-Kopplung (1)
- HPLC-Methodenentwicklung (1)
- HSD3B2 (1)
- Habitat (1)
- Halbleitergrenzflächen (1)
- Halbleiterphysik (1)
- Halobacterium halobium (1)
- Hand surgery (1)
- Handchirurgie (1)
- Handelsformat (1)
- Handelsforschung (1)
- Hautbiopsie (1)
- HeLa cells (1)
- Heidegger, Martin (1)
- Heilige (1)
- Heiliges Römisches Reich <Reichskammergericht> (1)
- Hepatitis B virus reactivation (1)
- Herzchirurgie (1)
- Herzschrittmacher (1)
- Hessen (1)
- Heterocyclische Verbindungen (1)
- Heterostruktur (1)
- Heubacillus (1)
- HeuristicsMiner algorithm (1)
- Heuschrecken <Überfamilie> (1)
- Hexaarylbenzole (1)
- Hg1-xCdxTe (1)
- Higgs-Teilchen (1)
- Hilfsmittel (1)
- Hilfsverb (1)
- Hinderniserkennung (1)
- Hirninfarkt (1)
- Hirntumor (1)
- Hirschsprung disease (1)
- Histon-Demethylase Kdm6a (1)
- Hochauflösendes Verfahren (1)
- Hochmagnetfeld (1)
- Hochschulpolitik (1)
- Hodgkin-lymphoma (1)
- Holzminden (1)
- Homoarginin/homoarginine (1)
- Homoptera aphididae (1)
- Honeybee (1)
- Honigbiene (1)
- Host cell death (1)
- Hubbard-Modell (1)
- Human Factors (1)
- Human Host (1)
- Human papillomavirus (1)
- Humanismus (1)
- Hydrogel (1)
- Hydrogele (1)
- Hydrophober Effekt (1)
- Hydroxylapatit (1)
- Hydroxyäthylstärke (1)
- Hymenoptera (1)
- Hyperinsulinämie (1)
- Hypertension (1)
- Hyperthermie (1)
- Hypertonie (1)
- Hyponatriämie (1)
- Hypoxie (1)
- HÄS (1)
- Hämatopoese (1)
- Hämodialyse (1)
- Höhle (1)
- Höhle <Motiv> (1)
- Hörspiel (1)
- Hörspieltheorie (1)
- Höxter (1)
- I-tasser (1)
- ICD-10 (1)
- ICT (1)
- IFN-γ (1)
- IGF-1 (1)
- III adenylyl cyclases (1)
- III secretion (1)
- III secretion system (1)
- IKK (1)
- IL-12B (1)
- IL-12p40 (1)
- IL-15 (1)
- IL-17 (1)
- IL-2 (1)
- IL-4 (1)
- IL-5 (1)
- IL-6 Inhibition (1)
- IL12B (1)
- IL8 (1)
- IMA2.1 (1)
- ISPMF (1)
- ITO (1)
- ITS2 (1)
- IaaS (1)
- Identitätsbildung (1)
- Identitätsentwicklung (1)
- Ileal Trasposition (1)
- Illusorische Korrelation (1)
- Image Computation (1)
- Iminoborylkomplexe (1)
- Iminogruppe (1)
- Immobilisiertes Enzym (1)
- Immunaktivierung (1)
- Immune (1)
- Immunglobuline (1)
- Immunologie (1)
- Immunology (1)
- Immunrekonstitution (1)
- Immuntherapie (1)
- Impfplan (1)
- Impfung (1)
- Implantate (1)
- Impulsformung (1)
- Impulsivität (1)
- In vitro (1)
- Indian Economy (1)
- Indian Hedgehog (1)
- Indien / Government (1)
- Indien / Parliament / House of the People (1)
- Indikationsstellung (1)
- Infektionsbildgebung (1)
- Infektionsprophylaxe (1)
- Infertilität (1)
- Inflammasom (1)
- Inflammation (1)
- Information Extraction (1)
- Information Retrieval (1)
- InhA (1)
- Innere Uhr (1)
- Innovation (1)
- Instrument Control Toolbox (1)
- Insulin (1)
- Insulinresistenz (1)
- Interaction analysis (1)
- Interaktion (1)
- Interaktive Karten (1)
- Interdisziplinäre Schmerztherapie (1)
- Interessenspolitik (1)
- Intergeneration (1)
- Interkalation (1)
- Interleukin 4 (1)
- Interleukin 6 (1)
- Internationale Politik (1)
- Internationaler Wettbewerb (1)
- Intersystem Crossing (1)
- Intracellular replication (1)
- Intraorale Infektionen (1)
- Ionische Flüssigkeiten (1)
- Iridiumkomplexe (1)
- Isonitrilinsertion (1)
- Italienische Literatur (1)
- J-aggregate behavior (1)
- Jacopone da Todi (1)
- Jacopone, da Todi : Laude (1)
- Jasmonsäure (1)
- Johnstons organ (1)
- K+ channel (1)
- K-PG radiation (1)
- K279a (1)
- K2P channels (1)
- KCNK5 (1)
- KDIGO (1)
- K\(_{2P}\)5.1 (1)
- Kanaloplastik (1)
- Kapitalverflechtung (1)
- Kapitalverflechtungen (1)
- Karbonylierung (1)
- Kardiochirurgie (1)
- Karriere (1)
- Katalysatorimmobilisierung (1)
- Kaufverhalten (1)
- Kehlkopf (1)
- Keloide (1)
- Kenia (1)
- Kerinokeratosis papulosa (1)
- Kettenblume (1)
- Kiefernrindenextrakt (1)
- Killerzelle (1)
- Kind (1)
- Kind / Onkologie (1)
- Kinderchirurgie (1)
- Kinderheilkunde (1)
- Kindesalter (1)
- Kindheit (1)
- Kinetik (1)
- Klassifikation (1)
- Kleidung (1)
- Klein, Georg / Arbeit am Blasator (1)
- Klein, Georg / Chicago / Baracken (1)
- Klimavariation (1)
- Klimawandel (1)
- Klinische Symptomatik (1)
- Knieschmerzen (1)
- Knochenqualität (1)
- Knochenregeneration (1)
- Knochenzement (1)
- Knockout <Molekulargenetik> (1)
- Knowledge-based Systems Engineering (1)
- Kognitive Störung (1)
- Kohlenhydrate (1)
- Kohlenmonoxid (1)
- Kohlenstoffmonoxid (1)
- Kohlenwasserstoffe (1)
- Kollisionsschutz (1)
- Kollisionsvermeidung (1)
- Kolloidale Volumenersatztherapie (1)
- Kolonialismus (1)
- Kolonialmacht Frankreich (1)
- Kommunikation <Motiv> (1)
- Kommunikationshilfe (1)
- Komplement (1)
- Komplexes System (1)
- Komplikation (1)
- Kompression (1)
- Kompressionsbekleidung (1)
- Kompressionstherapie (1)
- Komödie (1)
- Kondo cloud (1)
- Kondo effect (1)
- Konfidenzintervall (1)
- Konfliktverarbeitungstheorie (1)
- Konforme Abbildungen (1)
- Konfrontation zweier Kulturen (1)
- Konkurrentenstreitverfahren (1)
- Konkurrenzanalyse (1)
- Konstruktionsmethoden (1)
- Konsumentenverhalten (1)
- Kontrakttheorie (1)
- Kontrastmittel (1)
- Kontrolltheorie (1)
- Konvergenz (1)
- Konzentrationssprungmethode (1)
- Kooperative Umfelderfassung (1)
- Koronarchirurgie (1)
- Korpuslinguistik (1)
- Korrelation (1)
- Korrelationsfunktion zweiter Ordnung (1)
- Korruption (1)
- Korruption von Mitarbeitern (1)
- Kosmetik (1)
- Kotzebue, August von / Die edle Lüge (1)
- Kotzebue, August von / Menschenhaß und Reue (1)
- Krach (1)
- Kraftfeld (1)
- Krebs (1)
- Kreuzkupplungsreaktion (1)
- Kriegsliteratur (1)
- Kristall (1)
- Kristalloberfläche (1)
- Kritik (1)
- Kritik an Doering-Manteuffels Zeitbögen (1)
- Kuhblume (1)
- Königlich Spanische Akademie (1)
- L-DOPA (1)
- LCP (1)
- LEED (1)
- LIMK (1)
- LINC complex (1)
- LINE-1 retrotransposition (1)
- LIS (1)
- LPP (1)
- LTR retrotransposons (1)
- LULCC (1)
- La bolsa (1)
- La historia oficial (1)
- Lactobacillus acidophilus (1)
- Ladungsdichtewelle (1)
- Laktobazillen (1)
- Land (1)
- Land Cover Classification (1)
- Land Surface Temperature (LST) (1)
- Landau level (1)
- Landouzy-Déjerine-Atrophie (1)
- Landschaftsökologie (1)
- Landwirtschaft (1)
- Langzeitnachuntersuchung (1)
- Large Hadron Collider (1)
- Laserchirurgie (1)
- Lateinamerika (1)
- Laufkäfer (1)
- Lautstärkereduktion (1)
- Lebensführung (1)
- Lebensmitteleinzelhandel (1)
- Lebensqualität (1)
- Lebenssinn (1)
- Leberepithelzelle (1)
- Lectotypus (1)
- Legionella (1)
- Lehrprojekt (1)
- Leibniz, Gottfried Wilhelm (1)
- Leipzig (1)
- Leishmania major (1)
- Leistungsbewertung (1)
- Leistungssport (1)
- Leistungssteigerung (1)
- Leonhard-Klassifikation (1)
- Lepton-Flavour-Verletzung (1)
- Lernen (1)
- Libro de buen amor (1)
- Licht (1)
- Lieferantenwahl (1)
- Ligand (1)
- Lipid Rafts (1)
- Lippen-Kiefer-Gaumenspalte (1)
- Listeria monocytogenes (1)
- Literaturwissenschaft (1)
- Livre de la cité des dames (1)
- Ljapunov-Funktion (1)
- Ljapunov-Stabilitätstheorie (1)
- Ln-MOFs (1)
- Lobbyismus (1)
- Loewner theory (1)
- Loewner-Theorie (1)
- Logging (1)
- Lokalanästhesie (1)
- Lope de Vegas (1)
- Luciana Romano (1)
- Ludwig Borchardt (1)
- Lumineszenz (1)
- Lung Imaging (1)
- Lungenbildbgebung (1)
- Lungenfunktion (1)
- Lungenperfusion (1)
- Lungprotective Ventilation (1)
- Luxation (1)
- Luxationsrichtung (1)
- Lycopersicon esculentum (1)
- Lymphom (1)
- Lysin-Oxidase (1)
- Lysyl oxidases (1)
- Lysyloxidasen (1)
- Ländlicher Raum (1)
- Lärm (1)
- Lärmbelastung (1)
- Löwenzahn <Taraxacum> (1)
- Lügner (1)
- M1/M2 macrophages (1)
- MACE (1)
- MALDI-MS (1)
- MAP-Kinase (1)
- MAPK (1)
- MAPK signaling (1)
- MARC effect (1)
- MBE (1)
- MCPH1 (1)
- MEPE (1)
- MIC ligands (1)
- MITF (1)
- MMP-9 (1)
- MNS (1)
- MODIS image (1)
- MOF (1)
- MORN-repeat (1)
- MPFL-Rekonstruktion (1)
- MRI (1)
- MRSA (1)
- MRT der Lunge (1)
- MS (1)
- MSC (1)
- MSSS (1)
- MTOR (1)
- MYCN (1)
- MYCN-amplified (1)
- Machine Learning (1)
- Mackenzie-River-Delta (1)
- Macromolecular Assembly (1)
- Macromolecular Crystallography (1)
- Magenbypass (1)
- Magerrasen (1)
- Magnetfeld-Wechselwirkung (1)
- Magnetfeldsensor (1)
- Magnetic resonance (1)
- Magnetischer Röntgenzirkulardichroismus (1)
- Magnetometrie (1)
- Magnetresonanz-Enterographie (1)
- Mahlen (1)
- Main-Post (1)
- Majorana fermions (1)
- Makrophage (1)
- Makrophagen (1)
- Malaria (1)
- Mampu (1)
- Mangan (1)
- Mangansuperoxiddismutase (1)
- Manisch-depressive Krankheit (1)
- Mannheim (1)
- Markov-Ketten-Monte-Carlo-Verfahren (1)
- Marktgebiet (1)
- Marktgebietsmodelle (1)
- Marktstruktur (1)
- Martel, Julián (1)
- Masern (1)
- Mathematikunterricht (1)
- Matrix Effekte (1)
- Matrix of Democracy (1)
- Maxwell demon (1)
- Mbankana (1)
- Medien (1)
- Medienkonsum (1)
- Medienlinguistik (1)
- Medienwandel (1)
- Medizin (1)
- Medizinethik (1)
- Medizinische Ethik (1)
- Medizinphysik (1)
- Mediävistik (1)
- Mehragentensystem (1)
- Mehrkernige Komplexe (1)
- Mehrkernprozessor (1)
- Mekong-Delta (1)
- Melanin (1)
- Melanin release (1)
- Melanomzellen (1)
- Memory B cells (1)
- Mensch-Maschine-Interaktion (1)
- Mensch-Umwelt-Interaktion (1)
- Menschmaschineinteraktion (1)
- Mercury Telluride (1)
- Merocyanine (1)
- Merocyanine dye (1)
- Mesenchymale Stammzelle (1)
- Messenger-RNP (1)
- Messenger-RNS (1)
- Metabolic Glycoengineering (1)
- Metabolismus (1)
- Metagenom (1)
- Metallcarbonyle (1)
- Metallimplantat (1)
- Metallo-Polyelektrolyte (1)
- Metalloborylenkomplexe (1)
- Metallorganische Gerüstverbindung (1)
- Metallorganische Polymere (1)
- Metallorganische Verbindungen (1)
- Metallorganisches Netzwerk (1)
- Metapher (1)
- Metaphorik (1)
- Metastasektomie (1)
- Methandiid-basierte Carbenkomplexe (1)
- Methandiide (1)
- Methylphenidat (1)
- Metro (1)
- Metropolregion Rhein-Neckar (1)
- Mexiko (1)
- Micromorphologie (1)
- Microscopy (1)
- Mikrofluidikchip (1)
- Mikroglia (1)
- Mikrokern (1)
- Mikrokernfrequenzanalyse (1)
- Mikrokerntest (1)
- Mikroporosität (1)
- Mikrostruktur (1)
- Milchsäure (1)
- Milchsäurebakterien (1)
- Minister (1)
- Miró, José (1)
- Mischbarkeit (1)
- Mismatch (1)
- Mitogen-aktivierte Proteinkinase (1)
- Mitoxantron (1)
- Mittelalterdidaktik (1)
- Miz1 (1)
- Mizelle (1)
- Mobile Telekommunikation (1)
- Modalitätsverb (1)
- Modalverb (1)
- Modefachsprache (1)
- Model Checking (1)
- Modellierung (1)
- Modellprüfung (1)
- Modesprache (1)
- Molecular Chaperone (1)
- Molecular Phenomena (1)
- Molecular Simulation (1)
- Molecular dynamics (1)
- Molecular mechanics (1)
- Molekulare Phänomene (1)
- Molekulargenetik (1)
- Molekularstrahlepitaxie (1)
- Moleküldynamik (1)
- Monitoring (1)
- Monoklonaler Antikörper (1)
- Monsun (1)
- Montaigne, Michel Eyquem de (1)
- Montaigne, Michel Eyquem de / Essais info (1)
- Monte Carlo Simulation (1)
- Monte-Carlo Methods (1)
- Monte-Carlo-Simulation (1)
- Moonlight (1)
- Mosaik (1)
- Motoneuron (1)
- Motoneuronenerkrankung (1)
- Motor nerve biopsy (1)
- Multi-agent systems (1)
- Multiple Repräsentationen (1)
- Multiple Sklerose (1)
- Multiple representations (1)
- Multiple sclerosis (1)
- Multiplex-PCR (1)
- Mumps (1)
- Museum (1)
- Museumspädagogik (1)
- Muskelin (1)
- Mutation (1)
- Myc Transcription (1)
- Mycobacterium avium (1)
- Mycobacterium tuberculosis (1)
- Myelographie (1)
- Myokarditis (1)
- Myotonische Dystrophie (1)
- Mädchen (1)
- Mémoires de l’Académie des Colporteurs (1)
- München (1)
- N-Myc (1)
- N400 (1)
- NADPH oxidase inhibitors (1)
- NAFLD (1)
- NEXAFS spectroscopy (1)
- NF-Kappa B (1)
- NF-\(\kappa\)B (1)
- NF-κB (1)
- NFAT (1)
- NFATc1 (1)
- NFKB (1)
- NFkB-Signalling (1)
- NFκB-activation (1)
- NGS (1)
- NIR-Spektroskopie (1)
- NIRS (1)
- NKG2D (1)
- NKG2D ligands (1)
- NLRP3 (1)
- NMDA receptor subunits NR2A and NR2B (1)
- NMDA-Rezeptor (1)
- NMR relaxation (1)
- NMR-Spektroskopie (1)
- NOD (1)
- NOS1VNTR (1)
- NSN-Grenzfächen (1)
- NSN-junctions (1)
- NV-Zentren (1)
- Nabelhernie (1)
- Nachhaltige Entwicklung (1)
- Nachhaltige Siedlungsentwicklung (1)
- Nachhaltigkeit (1)
- Nachuntersuchung (1)
- Nah-Infrarot-Spektroskopie (1)
- Nahinfrarotspektroskopie (1)
- Nahtmaterial (1)
- Named-Entity-Recognition (1)
- Nampt (1)
- Nanodiamant (1)
- Nanokomposit (1)
- Nanolithografie (1)
- Nanomedicine (1)
- Nanomedizin (1)
- Nanoparticles (1)
- Nanorohr-Polymer-Komplexe (1)
- Narben (1)
- Narendra Modi (1)
- Narratologie (1)
- Native Chemical Ligation (1)
- Natriumkonsum (1)
- Naturstoff (1)
- Nd:YAG 1318nm (1)
- Ne (Negativity) (1)
- Nebenläufigkeit (1)
- Nebenniereninsuffizienz (1)
- Nebennierenrindenkarzinom (1)
- Nebennierenrindenkrebs (1)
- Nekroptose (1)
- Nekrose (1)
- Nephrologie (1)
- Nephrotoxizität (1)
- Nervenfaser (1)
- Nestbau (1)
- Networks (1)
- Netzwerkmanagement (1)
- Netzwerkverwaltung (1)
- Neue Medien (1)
- Neue Physik (1)
- Neue Welt (1)
- Neuroblastom (1)
- Neuroblastoma (1)
- Neurofeedback (1)
- Neurokognitive Funktion (1)
- Neuronal plasticity (1)
- Neuronale Plastizität (1)
- Neuropathie (1)
- Neuropathy (1)
- Neuropsychologische Diagnostik (1)
- Neurotoxizität (1)
- Neurotrophic factors (1)
- New physics (1)
- Next Generation Sequencing (1)
- Nicht-kartesische Bildgebung (1)
- Nichtglatte Optimierung (1)
- Nichtlineare Funktionalgleichung (1)
- Niederdimensionales System (1)
- Niedersachsen <Süd> (1)
- Nierentransplantation (1)
- Nierenversagen (1)
- Nietzsche, Friedrich <1844-1900> (1)
- Niger (1)
- Nisthilfe (1)
- Nitroxolin (1)
- Non-Cartesian Imaging (1)
- Nonequilibrium (1)
- Nonparametric Inference (1)
- Nonsmooth optimization (1)
- Nordrhein-Westfalen. Ministerium für Schule und Weiterbildung, Wissenschaft und Forschung (1)
- Normal Distribution (1)
- Nuklearfaktor Kappa B (1)
- Nuklearmedizin (1)
- Numerical Asset Valuation (1)
- Numerische Verfahren (1)
- Nutzen (1)
- Nutzenvergleich (1)
- Nährstoffaufnahme (1)
- OAT1 (1)
- OAT3 (1)
- OBDD (1)
- ODMR-Spektroskopie (1)
- OK cells (1)
- OSC (1)
- OWL (1)
- Oberfläche (1)
- Oberflächenfunktionalisierung (1)
- Oelze, Friedrich Wilhelm (1)
- Olig2 (1)
- Oligomerisation (1)
- Oligomerization (1)
- Oligonucleotide (1)
- Onboard (1)
- Oncolytic Vaccinia Virus Therapy (1)
- Onkolyse (1)
- Onkolytische Vaccinia Virustherapie (1)
- Online-Medien (1)
- Ontologie (1)
- Oozyte (1)
- Opioide (1)
- Optical spectroscopy (1)
- Optimal control problem (1)
- Optimierung (1)
- Optimization (1)
- Optische Spektroskopie (1)
- Optischer Resonator (1)
- Oral soft tissue infections (1)
- Orale Chirurgie, (1)
- Order Statistics (1)
- Organisation (1)
- Organisationskultur (1)
- Organisationspsychologie (1)
- Organisch-anorganischer Hybridwerkstoff (1)
- Organische Halbleiter (1)
- Organische Sulfide (1)
- Organokatalyse (1)
- Orientierungsmuster (1)
- Originators (1)
- Orobanche crenata (1)
- Osnabrück (1)
- Osteogenesis (1)
- Osteoporose (1)
- Ovarian (1)
- Oxoborane (1)
- Oxoborylkomplexe (1)
- P-glycoprotein (1)
- P-glycoprotein expression (1)
- P. falciparum (1)
- PBEF (1)
- PC-1 blockade (1)
- PC61, anti-CD25-antibody (1)
- PC62, anti-CD25-Antiörper (1)
- PCR (1)
- PD-1 (1)
- PD-L1 (1)
- PDE4-inhibitor roflumilast (1)
- PDXP (1)
- PET (1)
- PFS25 (1)
- PGAS (1)
- PHMB (1)
- PI3K (1)
- PLE spectroscopy (1)
- PLE-Spektroskopie (1)
- POEM (1)
- PVP-Iod (1)
- PaaS (1)
- Palliativmedizin (1)
- Paläoklima (1)
- Paläoklimamodellierung (1)
- Pan-Raf-Inhibition (1)
- Parallelisierung (1)
- Pareto-Verteilung (1)
- Parkinson (1)
- Parkinson's disease (1)
- Parlament (1)
- Participation (1)
- Passiv (1)
- Patellaluxation (1)
- Pathogener Mikroorganismus (1)
- Patientenautonomie (1)
- Patientenkomfort (1)
- Patientenrecht (1)
- Patientenverfügung (1)
- Patientenwille (1)
- Patientenwohl (1)
- Patterns (1)
- Perfluorkarbon (1)
- Period (1)
- Permeabilität (1)
- Peroxiredoxin (1)
- Peroxiredoxin 6 (1)
- Perylenderivate (1)
- Petropedetidae (1)
- PfAMA1 (1)
- PfCCp protein (1)
- Pflanzen (1)
- Pflanzengeographie (1)
- Pflanzenhormon (1)
- Pfs230 (1)
- Phagosom (1)
- Phagosomal escape (1)
- Phagozytose (1)
- Pharmaceutical markets (1)
- Pharmazeutische Industrie (1)
- Pharmazie (1)
- Phasenumwandlung (1)
- Phasic Fear (1)
- Phenomenology (1)
- Pheromon (1)
- Pheromon Kommunikation (1)
- Pheromon communication (1)
- Philosophy of Cognitive Science (1)
- Philosophy of Mind (1)
- Phonon (1)
- Phophorylierung (1)
- Phosphorylierung (1)
- Photoanregung (1)
- Photodissoziation (1)
- Photoelektron-Photoion-Koinzidenz (1)
- Photoelektronen-Photoionen-Koinzidenz (1)
- Photoluminescence (1)
- Photolumineszenz Quenching (1)
- Photosensibilisator (1)
- Phrynobatrachus amphibia (1)
- Phthalocyanin (1)
- Physik jenseits des Standardmodells (1)
- Physikalische Schicht (1)
- Phytohormon (1)
- Phänotypen (1)
- Plasmamembran (1)
- Plasmozytom (1)
- Platin (1)
- Platinkomplexe (1)
- Plosivsequenzen (1)
- Poetologie (1)
- Pol II (1)
- PolSAR (1)
- Polarimetrie (1)
- Polarisationspulsformung (1)
- Polariton (1)
- Polariton-Kondensation (1)
- Polistes (1)
- Political Freedom (1)
- Political Science (1)
- Political system (1)
- Politik (1)
- Politische Gleichheit (1)
- Politische Sprache (1)
- Politische Ökologie (1)
- Politisches System (1)
- Polo-like kinase 1 (1)
- Polyamin (1)
- Polyethylenglykole (1)
- Polyfluorene (1)
- Polyglycidol (1)
- Polymer (1)
- Polymerase-Kettenreaktion (1)
- Polymere (1)
- Polymerisation (1)
- Polymerkomplexe (1)
- Polymilchsäure (1)
- Polymorphismus (1)
- Polypeptidketten bindende Proteine (1)
- Poorly water soluble drugs (1)
- Populationsgenetik (1)
- Porphyrine (1)
- Portugiesisch (1)
- Poröser Stoff (1)
- Posaconazol (1)
- Postaggressorisches Syndrom (1)
- Postagressionsstoffwechsel (1)
- Postoperative Komplikationen (1)
- Postoperative Phase (1)
- Postoperative health related Quality of Life (1)
- Povidon-Iod (1)
- Povidoneiodine (1)
- Prediction interval (1)
- Prefrontalt Cortex (1)
- Preisvergleich (1)
- Presse (1)
- Prevention (1)
- Primärer Hirntumor (1)
- Primärrechtsschutz (1)
- Probenaufarbeitung (1)
- Processing Fluency (1)
- Produktinnovation (1)
- Programmverifikation (1)
- Prosaroman (1)
- Prostaglandin E2 (1)
- Protease (1)
- Proteaseaktivität (1)
- Proteaseinhibitor (1)
- Proteasen (1)
- Proteasomaler Abbau (1)
- Protected Area (1)
- Protein Expression (1)
- Protein crystal (1)
- Protein-Protein-Wechselwirkung (1)
- Proteine (1)
- Proton-Proton-Streuung (1)
- Provinz Coast (1)
- Präferenz (1)
- Präfrontaler Cortex (1)
- Pränatale Entwicklung (1)
- Präpositionalphrasen (1)
- Prävention (1)
- Pseudomonas aeruginosa (1)
- Psychologie (1)
- Puenzo, Luis (1)
- Pulmonale Applikation (1)
- Pulmonary delivery (1)
- Pulsar (1)
- Punktbeschriftungen (1)
- Pycnogenol (1)
- Pädiatrische Intensivstation (1)
- QW interface profile (1)
- Quadrocopter (1)
- Quadrokopter (1)
- Quality of Democracy (1)
- Qualität (1)
- Qualitätskontrolle (1)
- Quanten-Hall-Effekt (1)
- Quantenchemie (1)
- Quanteninformation (1)
- Quantensensor (1)
- Quantenspinsystem (1)
- Quantitative Sensorische Testung (1)
- Quantum control (1)
- Queneau, Raymond : Zazie dans le métro (1)
- RAD51C (1)
- REMPI (1)
- RESTORE protocol (1)
- RIP3 (1)
- RNA (1)
- RNA binding proteins (1)
- RNA polymerase II (1)
- RNA-seq (1)
- RNS-Interferenz (1)
- RNS-Polymerase II (1)
- RQQ domain (1)
- RS1 (1)
- RS1 Peptides (1)
- RS1 derived peptides (1)
- RSK (1)
- RSV-Infektion (1)
- RT-PCR (1)
- RT-qPCT (1)
- RTS,S/AS01 malaria vaccine (1)
- Radarfernerkundung (1)
- Radial Imaging (1)
- Radiale Bildgebung (1)
- Radikale (1)
- Radioastronomie (1)
- Radiofrequenzstrahlung (1)
- Radionuklid (1)
- Radionuklidtherapie (1)
- Raf-Kinasen (1)
- Raman-Spektroskopie (1)
- Ranidae (1)
- Ranunculus puberulus (1)
- Rapsanbau (1)
- Rashba Spin-Orbit Coupling (1)
- Rashba impurity (1)
- Rastertunnelmikroskopie (1)
- Raumfahrzeug (1)
- Raumordnung (1)
- Raumwirtschaftstheorien (1)
- Reachability Analysis (1)
- Reaktionskinetik (1)
- Reaktionsmechanismus (1)
- Real Academia Española (1)
- Rechenzentrum Universität Würzburg (1)
- Rechtsdogmatik (1)
- Rechtsschutz (1)
- Rechtsvergleich (1)
- Reference pricing schemes (1)
- Reflexa Roxb (1)
- Reform (1)
- Reform des Vergaberechts (1)
- Regionalmodell (1)
- Regionalplanung (1)
- Regionalvermarktung (1)
- Regionalwirtschaft (1)
- Regulatorischer T-Lymphozyt (1)
- Rehabilitation (1)
- Reinforcement Learning Theory (1)
- Reinheitsanalytik (1)
- Reißfestigkeit (1)
- Rekanalisation Hirninfarkt (1)
- Rekombination (1)
- Rekrutierungsstrategien (1)
- Relaxation (1)
- Relaxationszeit (1)
- Relevant market (1)
- Relief <Geografie> (1)
- Remission (1)
- Repression (1)
- Repräsentation <Motiv> (1)
- Resection arthroplasty (1)
- Resektionsarthroplastik (1)
- Resilienz (1)
- Resplex (1)
- Response shift (1)
- Retail (1)
- Retrospective Motion Compensation (1)
- Retrospektive Bewegungskorrektur (1)
- Reverse Transkriptase (1)
- Reversion (1)
- Rheumatoid arthritis (1)
- Rheumatoide Arthritis (1)
- Rhizarthrose (1)
- Rhizom (1)
- Rho-GTPasen (1)
- Rho-GTPases (1)
- Rho-Proteine (1)
- Rhodopsin 7 (1)
- Ribosome (1)
- Riemann Hypothesis (1)
- Riemannsche Zetafunktion (1)
- Rimbaud, Arthur : Les illuminations (1)
- Rimbaud, Arthur : Une saison en enfer (1)
- Ringerweiterungsreaktionen (1)
- Rippenserienfraktrur (1)
- Risikomanagement (1)
- Risk-sharing schemes (1)
- Rituximab (1)
- Romanische Sprachen (1)
- Routing (1)
- Ru(0001) (1)
- Ruiz, Juan (1)
- Ruiz, Juan : Libro de buen amor (1)
- Ruthenium (1)
- Röntgenabsorptionsspektroskopie (1)
- Röntgenemission (1)
- Röntgenspektroskopie (1)
- Röteln (1)
- S-layer protein (1)
- S. aureus (1)
- S6KII RSK (1)
- SAPT (1)
- SAR (1)
- SAR imagery (1)
- SARME · dental tipping · transpalatal distractor · hyrax appliance · three-dimensional (1)
- SDMA/SDMA (1)
- SEQ (1)
- SGLT1 (1)
- SHANK3 (1)
- SLAM (1)
- SMN (1)
- SNARC (1)
- SNARC effect (1)
- SOX9 (1)
- SPECT (1)
- SQUID (1)
- STAT3 (1)
- SUN domain proteins (1)
- SWNT-Ensemble (1)
- SWNT-ensemble (1)
- SaaS (1)
- Saccharomyces cerevisiae (1)
- Saccharomyces cerevisiae telomeres (1)
- Sahara (1)
- Salmeterol (1)
- Salmonella (1)
- Salmonella enterica Typhimurium strain SL1344 (1)
- Salmonella-containing vacuole (SCV) (1)
- Salmonella/microsome assay (1)
- Salz (1)
- Salzlösung (1)
- Sandwich-Verbindungen (1)
- Sartre, Jean-Paul (1)
- Satz (1)
- Satzglied (1)
- Schande (1)
- Schande <Motiv> (1)
- Scheimpflug (1)
- Schichtsilikat (1)
- Schilddrüsenkarzinom (1)
- Schistosoma mansoni (1)
- Schmerz (1)
- Schmerztagesklinik (1)
- Schockfront (1)
- Schreckreflex (1)
- Schreibdidaktik (1)
- Schrittmacher (1)
- Schulübergang (1)
- Schutzgruppe (1)
- Schwefel-Funktionalisierung (1)
- Schwere-Fermionen-System (1)
- Screeningtest (1)
- Seide (1)
- Seiden-Fibroin (1)
- Sekundärmetabolit (1)
- Sekundärwald (1)
- Selbst (1)
- Selbstassemblierung in Wasser (1)
- Selten-Erd-Chloride (1)
- Sepsis (1)
- Sequenzierung (1)
- Serumspiegelbestimmung (1)
- Service Learning (1)
- Shaggy (1)
- Shanghai (1)
- SiC vacancy defects (1)
- SiC-Fehlstellendefekte (1)
- Siedlungsgang (1)
- Sigmadivertikulitis (1)
- Signalqualität (1)
- Signaltransduktion (1)
- Signalweg (1)
- Sila-Substitution (1)
- Sila-Wirkstoff (1)
- Silicon carbide (1)
- Silicon vacancy (1)
- Silk Fibroin (1)
- Silk-Fibroin (1)
- Simkania (1)
- Simkania negevensis (1)
- Simulation (1)
- Simvastatin (1)
- Sleeping Beauty (1)
- Small nuclear RNP (1)
- Software (1)
- Software-Modellierung (1)
- Software-Profiling (1)
- Sol (1)
- Sol-Gel-Synthese (1)
- Sol-Gel-Verfahren (1)
- Solarzellen (1)
- Sonderabgabe (1)
- Sonderpädagogik (1)
- Sonnenwind (1)
- Sorptionsstudien (1)
- South Korea (1)
- Southeast China (1)
- Soziales Netzwerk (1)
- Sozialpsychologie (1)
- Spacecrafts (1)
- Spaltöffnung (1)
- Spam Detection (1)
- Spanien (1)
- Spanisch (1)
- Spanische Literatur (1)
- Spektrale Diffusion (1)
- Spektroelektrochemie (1)
- Spektroskopie (1)
- Spektroskopische Flussmessung (1)
- Spermin (1)
- Sphingosine 1-Phosphate (1)
- Spiegelneuron (1)
- Spin defect (1)
- Spin flip (1)
- Spin systems (1)
- Spin-Gitter-Relaxation (1)
- Spinalkanalstenose (1)
- Spinchemie (1)
- Spinpolarisierte Rastertunnelmikroskopie, Temperaturabhängige Phasenübergänge (1)
- Spinsystem (1)
- Spiroergometrie (1)
- Spleißosom (1)
- Sport (1)
- Sprachentwicklung (1)
- Sprachwandel (1)
- Spray drying (1)
- Sprunggelenksfrakturen (1)
- Sprungmodell (1)
- Sprühtrocknung (1)
- Spumaviren (1)
- Spätschaden (1)
- Squalius alburnoides (1)
- Sr\(_2\)RuO\(_4\) (1)
- Stadtplanung (1)
- Standardmodell <Elementarteilchenphysik> (1)
- Standortpolitik (1)
- Standorttheorien (1)
- Starch volumetherapy nephrotoxicity HK-2 cells (1)
- Starry Sky (1)
- Startle (1)
- Statistics (1)
- Statistische Mechanik (1)
- Statistische Physik (1)
- Steady-State Sequences (1)
- Steady-State-Sequenzen (1)
- Steifigkeit (1)
- Stenotrophomonas maltophilia (1)
- Stent Retriever Schlaganfall (1)
- Step Ru surface (1)
- Sterblichkeit (1)
- Sterilität (1)
- Steroidogenese (1)
- Steuerrecht (1)
- Steuerungstechnik (1)
- Stickstoffheterocyclen (1)
- Stickstoffmonoxid (1)
- Stickstoffmonoxid-Synthase (1)
- Stilles Lesen (1)
- Stochastic Process (1)
- Stochastischer Prozess (1)
- Stomata (1)
- Stoßfreies Plasma (1)
- Stoßwelle (1)
- Strahlensensibilisator (1)
- Strahlentherapie (1)
- Strahlungsloser Übergang (1)
- Streptomyces (1)
- Structrual Model (1)
- Struktur (1)
- Strukturanalyse (1)
- Sub-saharan Africa (1)
- Subjektive Theorie (1)
- Substruktur (1)
- Suicidal behavior (1)
- Suizidalität (1)
- Sunitinib (1)
- SuperSAGE (1)
- Supercapacitor (1)
- Superkondensator (1)
- Supernovaüberrest (1)
- Supersaturation (1)
- Supraleiter (1)
- Supraleitung (1)
- Suralisneurographie (1)
- Surface Urban Heat Island (SUHI) (1)
- Sustained Fear (1)
- Symbolic Model Checking (1)
- Symmetry Reduction (1)
- Symptom (1)
- Synapse (1)
- Synapses (1)
- Synchrotronstrahlung (1)
- Syncytin (1)
- Synthese-Baustein (1)
- Synthetic Aperture Radar (1)
- Systemic Risk (1)
- Szilárd (1)
- Sánchez Ferlosio, Rafael : El Jarama (1)
- Säkularismus (1)
- Säugling (1)
- Süddeutsche Zeitung (1)
- Südwestdeutschland (1)
- T Zelle (1)
- T cell activation (1)
- T cell assay (1)
- T-Lymphozyten-Rezeptor (1)
- T-Zelle (1)
- T-cadherin (1)
- T-cells (1)
- T1-Relaxtion (1)
- T1-Wichtung (1)
- T2* (1)
- T2*-Relaxation (1)
- TAB08 (1)
- TAF (1)
- TASK2 (1)
- TEN (1)
- TH1-induced senescence (1)
- TH17 cells (1)
- TI (1)
- TKTL1 (1)
- TLR7 (1)
- TLR8 (1)
- TNF (1)
- TNG1412 (1)
- TPCA1 (1)
- TRAF1 (1)
- TRIP6 (1)
- Tabu (1)
- Tagesrhythmus (1)
- Tagging (1)
- Tagung (1)
- Tanzania (1)
- Taraxacum (1)
- Tauchbeschichtung (1)
- Taxonomie (1)
- TbMORN1 (1)
- Teaching (1)
- Technetium Tc 99m Sestamibi Rats (1)
- Technik (1)
- Teilchenbeschleunigung (1)
- Temperaturabhängigkeit (1)
- Tensid (1)
- Terms and Conditions (1)
- Terpyridin <2,2':6',2''-> (1)
- TerraSAR-X (1)
- Testament (1)
- Testamentsrecht (1)
- Testamentsstreitigkeiten (1)
- Textlinguistik (1)
- Th17 (1)
- Thalidomid (1)
- Theater <Motiv> (1)
- Theologie (1)
- Theorie des Verstärkungslernens (1)
- Therapeutical application (1)
- Therapeutisches Drug Monitoring (1)
- Therapy (1)
- Thermoelektrizität (1)
- Thermoregulation (1)
- Thiazol (1)
- Thiazole (1)
- Thiazolidindione (1)
- Thiol-Ene-Click-Chemie (1)
- Thiolate (1)
- Thoraxchirurgie (1)
- Thoraxdrainage (1)
- Thrombolysis stroke (1)
- Thrombozyt (1)
- Thrombozytenaggregationshemmung (1)
- Thymektomie (1)
- Tibet (1)
- Tieftemperatur (1)
- Tieftemperatur-Rastertunnelmikroskopie (1)
- Timeless (1)
- Timm, Uwe / Freitisch (1)
- Tirso, de Molina (1)
- Tirso, de Molina : El burlador de Sevilla y convidado de piedra (1)
- Tissue Engineering (1)
- Toll-like-Rezeptoren (1)
- Topografie (1)
- Topological Insulator (1)
- Topological edge states (1)
- Topological insulator (1)
- Topologie (1)
- Topologische Randkanäle (1)
- Toulouse point (1)
- Toxizitätstest (1)
- Trabekulektomie (1)
- Traffic Lights (1)
- Traffic psychology (1)
- Tragik (1)
- Training (1)
- Transcranial Magnetic Stimulation (1)
- Transcription (1)
- Transcription regulation (1)
- Transient Absorption Spectroscopy (1)
- Transiente Absorption (1)
- Transkriptionsfaktor (1)
- Transparent-leitendes Oxid (1)
- Transwell® system (1)
- Trapeziometacarpal osteoarthritis (1)
- Treg (1)
- Triad (1)
- Triazin (1)
- Triple Awareness Fusion (1)
- Troyes, Kristian von (1)
- Trypanosoma brucei (1)
- Tryptophan hydroxylase-2 (Tph2) (1)
- Tumor (1)
- Tumorerkrankungen (1)
- Tumorzelle (1)
- Tumour (1)
- Twilight (1)
- Typ 2 (1)
- Type 1 Diabetes (1)
- Tyrosinkinaseinhibitor (1)
- UI and Interaction Design (1)
- UTX (1)
- Ubiquitinierung (1)
- Uganda (1)
- Ulrakurze Echozeit (1)
- Ultimatum Game (1)
- Ultrakurzer Lichtimpuls (1)
- Umfrage (1)
- Unified Monitoring (1)
- United States (1)
- Unmanned Aerial Vehicle (1)
- Unternehmensbewertung (1)
- Unternehmenskooperation (1)
- Unternehmensteuerharmonisierung (1)
- Unternehmer (1)
- Untertyp (1)
- Upper Guinea (1)
- Urodela (1)
- Usability (1)
- User Participation (1)
- User Training (1)
- V-antigen (1)
- V. wallichii (1)
- VACV (1)
- VAChT (1)
- VCAM-1 (1)
- VIBE (1)
- VLBWI (1)
- VYOO VYOO-PCR (1)
- Vacuum stability (1)
- Valeriana wallichii (1)
- Vascular endothelial Growth Factor (1)
- Vega Carpio, Lope Félix de : El villano en su rincón (1)
- Vektorboson (1)
- Vektorfeldformer (1)
- Vektorfeldkontrolle (1)
- Velocity-Map-Imaging (1)
- Venenentnahmetechnik (1)
- Venusfliegenfalle (1)
- Verarbeitungsflüssigkeit (1)
- Verbindungen (1)
- Verbraucherverhalten (1)
- Verbrückte Verbindungen (1)
- Verdunstung (1)
- Vergaberecht (1)
- Vergleichende politische Wissenschaft (1)
- Verkapselung (1)
- Verkehrsteilnehmer (1)
- Verlgeich (1)
- Vermahlung (1)
- Vermarktung (1)
- Vertikalvereinbarungen (1)
- Verunreinigung (1)
- Verzerrte Kognition (1)
- Verzerrung (1)
- Vietnam (1)
- Villano en su rincón (1)
- Visualisierung (1)
- Volkssprache (1)
- Volumensubstitution (1)
- Volumentherapie (1)
- Vorläuferzelle (1)
- W Arly Pendjari WAP (1)
- WB-DW-MRI (1)
- WD40 (1)
- WF (1)
- WH2 domain (1)
- WNT5A (1)
- WSM (1)
- WUEP-KD (1)
- Wahrnehmung (1)
- Wandel (1)
- Wasini Island (1)
- Wasserlöslichkeit (1)
- Wassertransport (1)
- Waxy papulosis of childhood (1)
- Web2.0 (1)
- Wechselwirkung (1)
- Wechselwirkungen (1)
- Weighted Filter (1)
- Weisheitszahnextraktion (1)
- Weltgesundheitsorganisation. Expert Committee on Prevention Methods and Programmes for Oral Diseases (1)
- Welttheater (1)
- Wert (1)
- Wertigkeit (1)
- Wespen (1)
- Westafrika (1)
- Westfalen <Südost> (1)
- Wettbewerbsstrategie (1)
- Wettkampf (1)
- Wilms tumour (1)
- Wirbelkanalstenose (1)
- Wireless Mesh Networks (1)
- Wirtschaftsinformatik (1)
- Wirtszelle (1)
- Wissensbasiertes System (1)
- Wnt (1)
- Wnt signalling (1)
- Wnt-signalling (1)
- Word-preferences (1)
- Wort (1)
- Wort-Präferenzen (1)
- Wortart (1)
- Wundinfektion (1)
- Wundnaht (1)
- Wundspülung (1)
- Wundversorgung (1)
- Wärmeleitfähigkeit (1)
- Wärmeübertragung (1)
- X. laevis-type karyotype (1)
- X. tropicalis-type karyotype (1)
- Xenopus (1)
- Xenopus laevis (1)
- Xenopus tropicalis (1)
- Xiphophorus (1)
- Y chromosome (1)
- Y-gastric bypass (1)
- Yersinia enterocolitica (1)
- Yukawa coupling (1)
- Zahnmedizin (1)
- Zeitaufgelöste Photolumineszenz (1)
- Zeitaufgelöste Spektroskopie (1)
- Zeitauflösung (1)
- Zeitgeber (1)
- Zeitung (1)
- Zeitzeuge (1)
- Zellteilung (1)
- Zelltod (1)
- Zellzyklus (1)
- Zero-inflation (1)
- Zeta-function (1)
- Zirkulardichroismus Spektroskopie (1)
- Zonula Occludens-1 (1)
- Zorn <Motiv> (1)
- Zweiteilung des Vergaberechts (1)
- Zweitmalignom (1)
- Zweitspracherwerb (1)
- Zweittumor (1)
- \(\alpha\)-latrotoxin (1)
- \(\alpha\)-phase (1)
- \(\beta\)-phase (1)
- \(\gamma\)h2ax (1)
- \(^{11}\)C-Methionine-PET (1)
- \(^{18}\)F-FDG PET/CT (1)
- abnormalities (1)
- abundance (1)
- accelerator based radiosurgery (1)
- acceptance (1)
- accuracy motivation (1)
- achalasia (1)
- achilles (1)
- acoustic startle (1)
- acoustic surface plasmon (1)
- acquisition (1)
- acromyrmex ambiguus (1)
- actin nucleation (1)
- actinobacteria (1)
- action potentials (1)
- active antiretroviral therapy (1)
- active pharmaceutical ingredient (1)
- acts downstream (1)
- acute MK-801 (1)
- acute kidney injury (1)
- acute leukemia (1)
- acute liver failure (1)
- acute lung injury (1)
- acute management of stroke (1)
- acute myeloid leukemia (1)
- acute neurology (1)
- acute stroke (1)
- acute stroke imaging (1)
- acute stroke management (1)
- acute stroke outcome (1)
- adaptations (1)
- adaptive growth (1)
- additive manufacturing (1)
- adenosine kinase (1)
- adherence (1)
- adipocytes (1)
- adipocytokines (1)
- adjunct (1)
- adrenal (1)
- adrenocortical (1)
- adult ADHD (1)
- adult neurogenesis (1)
- advertising effects (1)
- aerobic performance (1)
- aerobic power (1)
- affect (1)
- affect misattribution procedure (1)
- affective S-R compatibility (1)
- affective consequences (1)
- age (1)
- agent-based model (1)
- aggression (1)
- aging-related disease (1)
- agreement (1)
- agricultural intensification (1)
- agricultural irrigation (1)
- agricultural landscapes (1)
- agriculture (1)
- agrobacterium tumefaciens (1)
- agroecosystems (1)
- agroforestry systems (1)
- agroinfiltration (1)
- air-liquid interface (1)
- albumins (1)
- alcohol (1)
- aldehydes (1)
- algorithm (1)
- algorithms (1)
- alignment (1)
- alkylidengruppe (1)
- allelic variant (1)
- alliance (1)
- allogene Stammzelltransplantation (1)
- allopolyploidy (1)
- allostatic load (1)
- alpha (1)
- alpha-globin (1)
- alpha-toxin (1)
- alveolar (1)
- alveolar echinococcosis (1)
- alzheimers disease (1)
- amino acid sequence (1)
- amino acids (1)
- amplification (1)
- amygdala response (1)
- anaerobic and aerobic testing (1)
- anaerobic threshold (1)
- analysis (1)
- ancestor (1)
- ancillary data (1)
- and justice for all (1)
- anemia (1)
- anesthesiologists (1)
- angeborenes Immunsystem (1)
- animal behavior (1)
- animal migration (1)
- animal model (1)
- animal sexual behavior (1)
- annual report (1)
- ansa-Komplexe/ ansa complexes (1)
- antagonist (1)
- antagonists (1)
- antennal lobe (1)
- anterior cingulate cortex (1)
- anterior insula (1)
- anti-biofilm (1)
- anti-schistosomal activity (1)
- antibacterial (1)
- antibacterial/antiviral drug (1)
- antibiotic production (1)
- antibiotic prophylaxis (1)
- antibiotics in oral surgery (1)
- antibody production (1)
- antigen (1)
- antike Wahrnehmungsmuster (1)
- antimicrobial activity (1)
- antimicrobial peptides (1)
- antisense RNA (1)
- antiseptics (1)
- anxiety disorders (1)
- anxiety sensitivity (1)
- anxiety-like behavior (1)
- anyons (1)
- apis mellifera (1)
- apixaban (1)
- apoE (1)
- apoe (1)
- apoptosis, Myc (1)
- appetitive Reaktionstendenzen (1)
- approach and avoidance (1)
- approach-avoidance behavior (1)
- aqueous medium (1)
- aqueous solution (1)
- arachidonic acid (1)
- areas (1)
- argument (1)
- arm flexion (1)
- arms (1)
- armyworm Lepidoptera (1)
- arousal (1)
- arteriosclerosis (1)
- articulation (1)
- artificial membrane-permeability (1)
- ash (1)
- assemblages (1)
- assistive device (1)
- associated production (1)
- association studies in genetics (1)
- asthmatic bronchial epithelium (1)
- astrocytes (1)
- astrocytoma (1)
- asymmetry (1)
- asymptomatic patients (1)
- asymptomatische Patienten (1)
- atherosclerosis risk (1)
- atom (1)
- atomic gases (1)
- atrial fibrillation (1)
- attention deficit/hyperactivity disorder (1)
- atypical (1)
- auditory (1)
- auditory BCI (1)
- auditory brain-computer interface (1)
- autoimmune diseases (1)
- autoimmune neuroinflammation (1)
- autologous transplantation (1)
- automated external defibrillators (1)
- automated map labeling (1)
- automatic evaluation (1)
- automatische Beschriftungsplatzierung (1)
- autonomous (1)
- autopolyploidy (1)
- auxins (1)
- avascular necrosis (1)
- avidity (1)
- awareness (1)
- axonal damage (1)
- axonal injury (1)
- axonal transport (1)
- axonaler Transport (1)
- axonally transported proteins (1)
- axons (1)
- b2b (1)
- bacillus subtilis (1)
- backpack mobile mapping (1)
- bacteria (1)
- bacterial biofilms (1)
- bacterial invasion (1)
- bacterial lipoproteins (1)
- bacterial pathogens (1)
- bacteriorhodopsin (1)
- bacterium Legionella pneumophila (1)
- bagworms Lepidoptera (1)
- balance (1)
- balance hypothesis (1)
- balanced SSFP (1)
- bale mountains national park (1)
- balloon kyphoplasty (1)
- band SAR data (1)
- bariatric surgery (1)
- bark beetles (1)
- barrier (1)
- barrier integrity (1)
- barrier properties (1)
- base excision repair (1)
- bathophenanthroline (1)
- bax (1)
- bead models (1)
- beetle horns (1)
- behavioral conditioning (1)
- beige adipocytes (1)
- benchmarking (1)
- benzodiazepines (1)
- beta cell function (1)
- beta oscillations (1)
- beta-aminopropionitrile (1)
- beta-catenin (1)
- beta-diveristy (1)
- beta-lactamase inhibition (1)
- beta-lactamases (1)
- beyond Standard Model (1)
- biased dispersal (1)
- bile duct (1)
- biliopancreatic diversion (1)
- binding protein (1)
- binding protein HFQ (1)
- binge eating (1)
- biochemical simulations (1)
- biocide polyhexamethylene biguanide (1)
- biodegradable polymer (1)
- biodegradable polymers (1)
- biodiversity hotspot (1)
- biodiversity-ecosystem functioning (1)
- bioinformatics and computational biology (1)
- biological activity (1)
- biological control (1)
- biological pest control (1)
- biologische Körperflüssigkeiten (1)
- biology (1)
- biomaterial surfaces (1)
- biopharmaceuticals (1)
- biosphere reserve (1)
- biosynthesis (1)
- bipolar disorder (1)
- bipolare Störung (1)
- birth cohort (1)
- blastocysts (1)
- blood brain barrier (1)
- blood coagulability (1)
- blood flow (1)
- blood fluke (1)
- blood lactate (1)
- blood lipids (1)
- blood lymphocytes (1)
- blood pressure (1)
- blood-glucose (1)
- boat conformation (1)
- body weight (1)
- body-size (1)
- bola-amphiphile (1)
- bone (1)
- bone cement (1)
- bone colonization (1)
- bone formation (1)
- bone marrow failure syndrome (1)
- bone regeneration (1)
- bone-disease (1)
- bood (1)
- boron-doped diamond (1)
- bortezomib (1)
- boson (1)
- boundary cap (1)
- bovine lactoferricin (1)
- bradykinesia (1)
- brain activation (1)
- brain computer interface (1)
- brain development (1)
- brain dynamics (1)
- brain metastases (1)
- brain potentials (1)
- brain reactivity (1)
- brain tumors (1)
- brain-computer interfaces (1)
- branding (1)
- breaking (1)
- breast cancer cells (1)
- breath-hold (1)
- breathing (1)
- brush cell (1)
- brushite cement (1)
- buildings (1)
- burkholderia cenocepacia (1)
- burning pain (1)
- business (1)
- cAMP (1)
- cEND (1)
- cGMP (1)
- cIAP (1)
- cabbage Brassica oleracea var. capitata (1)
- calcareous grassland (1)
- calcitonin (1)
- calcium level (1)
- calcium phosphate cements (1)
- calibration and validation (1)
- calpain (1)
- camponotus floridanus (1)
- canal surgery (1)
- canaloplasty (1)
- cancer cell lines (1)
- cancer patients (1)
- cancer surveillance (1)
- cancer-targeted IL-12 (1)
- candida genome database (1)
- canine cancer cell lines (1)
- canine cancer therapy (1)
- canine soft tissue sarcoma (CSTS) (1)
- cannons (1)
- capability (1)
- capacity (1)
- capture-mark-recapture (1)
- carbon (1)
- carbon dioxide avoidance (1)
- carbon nanotubes and fullerenes (1)
- carbonaria (1)
- carbonmonoxide (1)
- carcinoma (1)
- carcinoma cells (1)
- carcinoma metastases to pancreas (1)
- cardiac magnetic resonance imaging (1)
- cardiac neurohormonal system (1)
- cardiac surgery (1)
- cardio-pulmonary resuscitation (1)
- cardiovascular arousal (1)
- cardiovascular diseases (1)
- cardiovascular events (1)
- cardiovascular magnetic resonance (1)
- cardiovascularm disease (1)
- carpenter ant (1)
- carrier transport (1)
- carrying capacity (1)
- carvacrol (1)
- case fatality rates (1)
- caspase activation (1)
- cataract surgery (1)
- ce compounds (1)
- celiac disease (1)
- cell (1)
- cell adhesion (1)
- cell binding assay (1)
- cell culture (1)
- cell cultures (1)
- cell cycle arrest (1)
- cell fate (1)
- cell fusion (1)
- cell lung cancer (1)
- cell size (1)
- cell stretch (1)
- cellular camp (1)
- cellular physiology (1)
- cellular senescence (1)
- central asia (1)
- centrality (1)
- cepedia complex (1)
- cerebellum (1)
- cerebral aspergillosis (1)
- cerebral asymmetry (1)
- cerebral calcification (1)
- cerebral cortex (1)
- cerebral gliomas (1)
- cerebral ischemia (1)
- cerebrospinal fluid (1)
- cervical dystonia (1)
- chalcogenides (1)
- channel (1)
- channelrhodopsin-2 (1)
- charge transport (1)
- charge-separated state (1)
- charged aerosol detector (1)
- charged heavy long-lived particles (1)
- chargino (1)
- chemotherapy (1)
- chest-compression rate (1)
- chewed (1)
- childhood asthma (1)
- chip-seq (1)
- chirality-sensitive spectroscopy (1)
- chlamydia infection (1)
- chlamydia trachomatis (1)
- cholinergic (1)
- chondrodysplasia (1)
- chondrosarcoma (1)
- chordotonal organs (1)
- chromatin mobility (1)
- chromosome 11Q13 (1)
- chromosome staining (1)
- chronic cerebrovascular disease (1)
- chronic distress (1)
- chronic heart failure (CHF) (1)
- chronic hepatitis C (1)
- chronic social stress (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronic viral infection (1)
- chronical stress (1)
- chronisch-entzündliche Darmerkrankung (1)
- chronischer Stress (1)
- cigarette smokers (1)
- cigarette smoking (1)
- cinematographic analysis (1)
- circadian rhythms (1)
- circular arc polygon domain (1)
- circular dichroism spectroscopy (1)
- circulating micrornas (1)
- circumferential viscodilation (1)
- circumplex model (1)
- cirrhosis (1)
- cities (1)
- citral (1)
- citrus (1)
- classical conditioning (1)
- clavicular fracture (1)
- click chemistry (1)
- climate change impact (1)
- clinical application (1)
- clinical manifestations (1)
- clinical risk score (1)
- clinical trial (1)
- clock reproduction ecology (1)
- cloning of putative human promoter sequence (1)
- cluster dynamical mean-field theory (1)
- co-immunoprecipitation (1)
- coated vesicles (1)
- coatings (1)
- coefficient (1)
- cofactors (biochemistry) (1)
- coffin-lowry-syndrome (1)
- cognition (1)
- cognitive bias (1)
- cognitive control (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive function (1)
- cognitive remediation (1)
- coherence (1)
- coherent control (1)
- coincidence (1)
- collision avoidance (1)
- colloids (1)
- colonialism (1)
- colony morphotypes (1)
- colony-stimulating factor (1)
- color discrimination (1)
- colour flow (1)
- combination testing (1)
- combination therapy (1)
- comet assay (1)
- communication systems (1)
- communities (1)
- community (1)
- community composition (1)
- community functional-responses (1)
- comparison (1)
- compartment boundary (1)
- compatibility (1)
- competitive sports (1)
- complete genome sequence (1)
- complex chromosome rearrangements (1)
- complex networks (1)
- complex traits (1)
- components (1)
- compound eye (1)
- comprehensive psychosomatic assessment (1)
- compressive strength (1)
- computational prediction (1)
- computational systems biology (1)
- computer-assisted instruction (1)
- concomitant radiotherapy (1)
- confinement-deconfinement transition (1)
- conformal mapping (1)
- conjugated honeycomb-chained-trimer (1)
- consensus conference (1)
- consensus statement (1)
- consortium (1)
- consumers (1)
- contemporary German (1)
- context effects (1)
- contributes (1)
- control profiles (1)
- control strain (1)
- cooperation (1)
- cooperativity (1)
- coordination polymer (1)
- copy number (1)
- coronary artery bypass grafting (1)
- coronary artery disease (1)
- corporate groups (1)
- correlation (1)
- corrupt organizational culture (1)
- corruption (1)
- cortex (1)
- cortical OAT1 (1)
- cortical activation (1)
- cortical magnification factor (1)
- cortical oscillatory activity (1)
- cortical pathology (1)
- corticosteroid withdrawal (1)
- corticosteroid-free immunosuppression after renal transplantation (1)
- corticosteroids (1)
- cost-effectiveness (1)
- costs (1)
- cotransporter SGLT1 (1)
- coupling strength (1)
- crab pulsar (1)
- craving (1)
- cravings (1)
- creatinine (1)
- crop harvest (1)
- cropping systems (1)
- cross-country skiers (1)
- cross-link repair (1)
- cross-lock (1)
- cross-ownership (1)
- croûtes (1)
- cruzi (1)
- crystal (1)
- crystal scructure (1)
- ctr (1)
- cultural differences (1)
- cutaneous adverse events (1)
- cutaneous lupus erythematosus (1)
- cuticular profiles (1)
- cutting edge (1)
- cycle (1)
- cyclists (1)
- cyclodextrin formulations (1)
- cylindrical micelles (1)
- cystic fibrosis (1)
- cytoarchitectonic maps (1)
- cytochrome P450 2C9 (1)
- cytokine (1)
- cytokine expression (1)
- cytokine production (1)
- cytokine profiling (1)
- cytokine secretion kinetics (1)
- cytokines (1)
- cytokinins (1)
- cytolysis (1)
- cytomegalovirus (1)
- cytosolic pH (1)
- c‐Myc (1)
- dRNA-Seq (1)
- damage (1)
- damaged DNA (1)
- danazol (1)
- dandelion (1)
- dangerous world (1)
- darbepoetin alpha (1)
- dark matter (1)
- data (1)
- data acquisition (1)
- database (1)
- day length (1)
- death pathway sar locus (1)
- deaths (1)
- decays (1)
- decline (1)
- decompensated heart failure (1)
- deep brain stimulation (1)
- deepSuperSAGE (1)
- defects (1)
- defense and evasion strategies (1)
- defenses (1)
- deficit hyperactivity disorder (1)
- degeneration (1)
- deletion 17P (1)
- delineation (1)
- dendritic growth (1)
- dendritische Zelle (1)
- density functional theory (1)
- dentate gyrus (1)
- dependence (1)
- derivatives (1)
- dermatitis (1)
- determinants (1)
- determination locus (1)
- determining genes (1)
- detoxification (1)
- development policy (1)
- developmental plasticity (1)
- diabetes typ 1 (1)
- diabetic kidney disease (1)
- diagnostic accuracy (1)
- diagnostics (1)
- dialysis (1)
- diboson production (1)
- dicholine succinate (1)
- dichteangepasste k-Raum Abtastung (1)
- dietary sodium (1)
- difference water index (1)
- differentially expressed genes (1)
- differentiated thyroid tumor (1)
- diffraction (1)
- diffraction limit (1)
- diffusion (1)
- diffusion weighted MRI (1)
- dihydrate cement (1)
- diindenoperylene (1)
- dimensions (1)
- dimethyl fumarate (1)
- dip-coating (1)
- diphoton decay (1)
- diploidization (1)
- direct oral anticoagulants (1)
- direct thrombin inhibitor (1)
- direction selectivity (1)
- discovery (1)
- discrete-to-continuum (1)
- disease comorbidities (1)
- disease severity (1)
- disease-modifying therapy (1)
- dislocation (1)
- disorders (1)
- disorders of consciousness (1)
- dispersal (1)
- disruption project (1)
- dissection (1)
- dissociation (1)
- distance measurement (1)
- distant metastases (1)
- diversity (1)
- division of labor (1)
- dodder (1)
- dolutegravir (1)
- domain K\(^{+}\) channels (1)
- domain genes A3(2) (1)
- domain potassium channels (1)
- dominant (1)
- donor-photosensibilisator-acceptor triad (1)
- dopamine (1)
- dorsolateraler Präfrontalkortex (1)
- dorsolateraler präfrontaler Cortex (1)
- dose response (1)
- dosimetry (1)
- double-blind (1)
- downconversion (1)
- downstream (1)
- droplet epitaxy (1)
- drosophila larvae (1)
- drug delivery (1)
- drug development (1)
- drug-delivery systems (1)
- drugs (1)
- du Pan dysplasia (1)
- dual setting (1)
- dunes (1)
- duodenal jejunal bypass (1)
- dyes (1)
- dysfunction (1)
- dysphagia (1)
- dysplasia (1)
- dégradation (1)
- dünner Filme (1)
- early onset sepsis (1)
- early stage (1)
- early-stage osteonecrosis (1)
- ecological relevant model (1)
- efficacy (1)
- efficiency (1)
- elastic fibers (1)
- elastin (1)
- electrochromic device (1)
- electrolytes (1)
- electromyographic activity (1)
- electron density (1)
- electron tomography (1)
- electronic properties and materials (1)
- electrooculography (1)
- electrophysiology (1)
- electrospinning (1)
- electroweak production (1)
- elektrochemische Bandlücke (1)
- elements (1)
- elevated plus-maze (1)
- elevator EMG activity (1)
- elispot (1)
- elongation (1)
- embodiment (1)
- embryonic stem cells (1)
- emotion regulation (1)
- emotional eating (1)
- emotional empathy (1)
- emotional experience (1)
- emotional responses (1)
- emphysema (1)
- employees' corruption (1)
- emtricitabine (1)
- enal impairment (1)
- encephalitis dementia (1)
- end-stage renal disease (1)
- end-stage renal failure (1)
- endocytic multivesicular bodies (1)
- endocytosis (1)
- endoplasmic reticulum (1)
- endoprosthetics (1)
- endoprothesis (1)
- endothelin-1 (1)
- endotoxemia (1)
- endovascular recanalization stroke (1)
- endovaskuläre Therapie Hirninfarkt (1)
- energetic jet (1)
- energy transfer dynamics (1)
- entanglement (1)
- enteric pathogens (1)
- enterica serovar Typhimurium (1)
- enterica serovar thphimurium (1)
- enteroendocrine cells (1)
- entorhinal cortex (1)
- entrainment (1)
- envelopment (1)
- environment interaction (1)
- environmental enrichment (1)
- environments (1)
- enzyme assays (1)
- enzyme metabolism (1)
- enzyme replacement therapy (1)
- epidemology (1)
- epidermal growth factor (1)
- epigenetics (1)
- epigenomic landscapes (1)
- epithelial cell culture (1)
- erectile dysfunction (1)
- ereigniskorrelierte Potentiale (1)
- ergodic transformation (1)
- eruption rate (1)
- erweiterte Eichsymmetrie (1)
- erythropoiesis-stimulating agents (1)
- esophagogastric junction (1)
- esophagoscopy (1)
- essential oils (1)
- essential tremor (1)
- ether (1)
- ethers (1)
- etomidate (1)
- eucalyptus (1)
- eugenyl cinnamate (1)
- eukaryotic gene expression (1)
- european beech forests (1)
- european countries (1)
- evaluation (1)
- evapotranspiration (1)
- event-related desynchronization (1)
- event-related fMRI (1)
- events (1)
- evozierte Potenziale (1)
- ex vivo expansion (1)
- excimer formation (1)
- excitation-secretion coupling (1)
- exciton (1)
- exciton blocking layer (1)
- exciton dynamics (1)
- exciton size (1)
- exercise therapy (1)
- exhaustion (1)
- exome (1)
- expectancy (1)
- experimental visceral leishmaniasis (1)
- expertise (1)
- explosive volcanism (1)
- exposure therapy (1)
- expression analysis (1)
- expression mutants (1)
- expression signature (1)
- expressive displays (1)
- extended gauge symmetry (1)
- extinction (1)
- extra Eichbosonen (1)
- extra gauge bosons (1)
- extracellular matrix (1)
- extrapulmonary (1)
- extrazelluläre Matrix (1)
- eye tracking (1)
- eyes (1)
- fMRI (1)
- fNIRS (1)
- face perception (1)
- face processing (1)
- face recognition (1)
- facial affect (1)
- facial electromyography (1)
- facial expression (1)
- facial muscle contractions (1)
- factor B (1)
- factor Sox10 (1)
- factor XA inhibitor (1)
- factor binding profiles (1)
- factor expression (1)
- familiarity (1)
- family (1)
- fat development (1)
- fatty liver disease (1)
- fear avoidance model (1)
- features (1)
- femtosecond pulse shaping (1)
- femtosecond spectroscopy (1)
- ferritin (1)
- fetal lung (1)
- fiber reinforcement (1)
- fibrinogen (1)
- fibroblast growth factor-23 (1)
- fibromyalgia syndrome (1)
- fibronectin-binding protein (1)
- field (1)
- field flow fractionation (1)
- filaggrin mutations (1)
- financial network (1)
- finanzielles Netzwerk (1)
- finite elements (1)
- firm valuation (1)
- fish (1)
- fishes Xiphophorus (1)
- flagellar motility (1)
- flexibility (1)
- flexible microcatheter (1)
- flies (1)
- flight phobics (1)
- flood detection (1)
- flood hazard index (1)
- flow (1)
- flow cytometry (1)
- flowers (1)
- fluctuation theorem (1)
- fluid (1)
- fluorescein isothiocyanate (1)
- fluorescence-detected sedimentation (1)
- fluorescent (1)
- flux (1)
- foamy viruses (1)
- focal cerebral ischemia (1)
- foci (1)
- food addiction (1)
- food allergy (1)
- food industry (1)
- food intake (1)
- football (1)
- forests (1)
- format (1)
- formulations (1)
- fortgeschrittenes Nebennierenkarzinom (1)
- fourier transform spectroscopy (1)
- fracture (1)
- fraxe mental retardation (1)
- free breathing (1)
- free choice (1)
- freie Atmung (1)
- french literature (1)
- fruit set (1)
- frühe Neuzeit (1)
- fully hadronic (1)
- functional analysis (1)
- functional characterization (1)
- functional magnetic resonance imaging (1)
- functional modules (1)
- fungal infections (1)
- fungal pathogens (1)
- funktionelle Lungenbildgebung (1)
- funktionelle Nachbehandlung (1)
- gadoxetic acid (1)
- gain (1)
- galactomannan (1)
- gall bladder (1)
- gametes (1)
- gametocyte (1)
- gamma astronomy (1)
- gamma knife radiosurgery (1)
- gamma-H2AX (1)
- gamma-convergence (1)
- gas (1)
- gastroduodenoscopie (1)
- gastrointestinal cancer (1)
- gating (1)
- gefitinib (1)
- gender differences (1)
- gene conversion (1)
- gene expression profiling (1)
- gene locus (1)
- gene mutations (1)
- gene ontology (1)
- gene regulation (1)
- gene regulator agr (1)
- gene-by-environment interaction (1)
- gene-environment interaction (1)
- generación del 14 (1)
- generación del 27 (1)
- generación del 98 (1)
- general anaesthesia (1)
- genetic interaction networks (1)
- genetic modifiers (1)
- genetic variation (1)
- genome (1)
- genome browser (1)
- genome cells (1)
- genome instability (1)
- genome wide (1)
- genome-wide association study (1)
- genomewide association (1)
- genomic analysis (1)
- genomic islands (1)
- genus (1)
- genus Xiphophorus (1)
- geographical information system (1)
- geprägte Gene (1)
- germination (1)
- giant pulses (1)
- glaucoma (1)
- glial cells (1)
- glioblastoma (1)
- glioblastoma stem cell (1)
- glioma (1)
- gliomas (1)
- global gene expression (1)
- global outcomes (1)
- glomerular filtration rate (1)
- glucagon like peptide-1 (1)
- glucose control (1)
- glutamate receptor (1)
- glycaemic control (1)
- glycerol (1)
- glycine receptor (1)
- glycogen synthase kinase-3β (1)
- glycolipids (1)
- glycolysis (1)
- goldfish optic nerve (1)
- gonopodium (1)
- graded activity (1)
- gram-negative bacteria (1)
- grand unification (1)
- grebe (1)
- gridle muscular-dystrophy (1)
- griechische Antike (1)
- grounded cognition (1)
- group consensus statement (1)
- growth and differentiation factor 5 (1)
- growth factor (1)
- growth-associated protein (1)
- growth-factor receptor 3 (1)
- guideline adherence (1)
- guides (1)
- gut hormones (1)
- habits (1)
- hadron colliders (1)
- hadronic decays (1)
- haemodiafiltration (1)
- halstedii JM8 (1)
- haplogroups (1)
- haploinsufficiency (1)
- hay fever (1)
- haze (1)
- hcv infection (1)
- head (1)
- head and neck cancer (1)
- head-mounted display (1)
- health (1)
- health care workers (1)
- health economics (1)
- healthy volunteers (1)
- hearing (1)
- heart valve (1)
- heat waves (1)
- helical liquid (1)
- helicopters (1)
- hemodiafiltration (1)
- hemodialysis (1)
- hemoglobin (1)
- hepatitis B (1)
- hepatitis B virus (1)
- hepatitis C virus (1)
- heptaocytes (1)
- heralded entanglement (1)
- herbivores (1)
- herbivorous insects (1)
- herpes simplex virus (1)
- heterogamety (1)
- heterogeneity (1)
- heterogenity (1)
- heterologous production (1)
- heterosis (1)
- hexaarylbenzenes (1)
- high energy (1)
- high intensity training (1)
- high risk (1)
- high throughput sequencing (1)
- high transverse momentum jets (1)
- high volume (1)
- high-energy collider experiment (1)
- high-risk cytogenetics (1)
- higher order methods (1)
- hip arthroplasty (1)
- hippocampal plasticity (1)
- hippocampal stem cells (1)
- hippocampal-neurons (1)
- histidine kinases (1)
- histology (1)
- histopathology (1)
- hnRNP K (1)
- home telemonitoring (1)
- homoeologous chromosomes (1)
- homologous recombination (1)
- honey bees (1)
- hopping model (1)
- host cells (1)
- host pathogen interaction (1)
- host pathogen interactions (1)
- host-pathogen adaption (1)
- host-pathogen interaction (1)
- hotspots (1)
- hubbard-model (1)
- human (1)
- human A(3) (1)
- human atherosclerotic lesions (1)
- human cytomegalovirus (HCMV) (1)
- human dendritic cells (1)
- human hepatic cells (1)
- human heptocytes (1)
- human immune system (1)
- human immunodeficiency virus (1)
- human macrophages (1)
- human melanoma (1)
- human muscle-cells (1)
- human orbitofrontal cortex (1)
- human osteosarcoma xenografts (1)
- human pathogen (1)
- human pathogenic fungi (1)
- human-immunodeficiency-virus (1)
- humane Keimzellen (1)
- humanized bone models (1)
- humanized mice (1)
- humans (1)
- hybrid origin (1)
- hybrid systems (1)
- hybridization (1)
- hybridogenesis (1)
- hybrids (1)
- hydrochloride (1)
- hydrodynamics (1)
- hydrogen bonding (1)
- hydrogen bonding mycobacterium tuberculosis (1)
- hymenoptera (1)
- hyperekplexia (1)
- hyperoxia (1)
- hyperpolarized HE-3 (1)
- hypertension (1)
- hypertrophic cardiomyopathy (1)
- hypotonic (1)
- hypotonic solutions (1)
- hypoxia (1)
- hypoxia inducible factor 1 (1)
- hypoxia-independent (1)
- hämatopoetisches Mosaik (1)
- i-131 uptake (1)
- iNKT (1)
- iNKT-Zellen (1)
- idiopathic inflammatory myopathies (1)
- idiopathic osteonecrosis (1)
- illumina MiSeq platform (1)
- illumination microscopy (1)
- illusory correlation (1)
- image (1)
- imaginal disk (1)
- imaging mass spectrometry (1)
- imaging techniques (1)
- imitatio (1)
- immersion (1)
- immpact recommendations (1)
- immune (1)
- immune cell function (1)
- immune cells (1)
- immune escape (1)
- immune system (1)
- immune thrombocytopenia (1)
- immunization (1)
- immuno suppression (1)
- immuno-magnetic purification (1)
- immunocompromised patients (1)
- immunocytokine (1)
- immunodeficiency (1)
- immunoglobulin light chain (1)
- immunohistochemistry (1)
- immunological cross-talk (1)
- immunologische Synapse (1)
- immunoprecipitation (1)
- immunoresistance (1)
- immunostaining (1)
- immunosurveillance (1)
- impact pharmacogenetics (1)
- implantation (1)
- implementation (1)
- implicit attitude measurement (1)
- import (1)
- improvement (1)
- improves (1)
- in vitro models (1)
- in vivo formation (1)
- in vivo polycomb (1)
- in-hospital cardiac arrest (1)
- inactivation (1)
- incompatible interaction (1)
- increased risk (1)
- incremental cost-effectiveness ratio (ICER) (1)
- independence (1)
- independent marker (1)
- indicators (1)
- individual radiosensitivity (1)
- induced (1)
- induced apoptosis (1)
- induced phase transition (1)
- inducible nitric oxide synthase (1)
- induction (1)
- inertial idiothetic navigation (1)
- infection prophylaxis (1)
- inferior parietal lobule (1)
- infiltration (1)
- inflammatory diseases (1)
- inflammatory pain (1)
- influenza (1)
- influenza A virus (1)
- information (1)
- information engine (1)
- infrared (1)
- infrared detectors (1)
- infrasound (1)
- inhibit (1)
- inhibitor (1)
- initial experience (1)
- initiation (1)
- initio molecular dynamics (1)
- injection site reactions; (1)
- injury (1)
- innere Umwandlung (1)
- innovatio (1)
- inpatient rehabilitation (1)
- insect (1)
- insect populations (1)
- insect timing (1)
- instinct (1)
- insufficiency (1)
- insulators (1)
- insulin receptor (1)
- intake (1)
- integral (1)
- integrase inhibitor (1)
- integrative genomics viewer (1)
- integrins (1)
- intensive care (1)
- interactive maps (1)
- interferon-\(\beta\) (1)
- intergroupe francophone (1)
- interleukin-4 (1)
- intermediate host snail (1)
- intermixing (1)
- internalization (1)
- international union (1)
- interolog (1)
- intestinal absorption (1)
- intestinal glucose (1)
- intestine (1)
- intra-individueller Vergleich (1)
- intracellular bacteria (1)
- intracellular pH (1)
- intracellular replication (1)
- intracerebral hemorrhage (1)
- intrahelical lesion (1)
- intraoperativ (1)
- intraoperative (1)
- invariant NKT cells (1)
- invariante NKT Zellen (1)
- inverse photoemission (1)
- iodine nutrition (1)
- iohexol (1)
- ionic selectivity (1)
- iridium complex (1)
- iron homeostasis (1)
- iron pnictides (1)
- irridation (1)
- ischaemic stroke (1)
- ischemia (1)
- ischemic acute kidney injury model (1)
- isoforms (1)
- isolierte Moleküle (1)
- isotonic (1)
- isotopolog profiling (1)
- issues (1)
- italian literature (1)
- italian patients (1)
- ivory coast (1)
- janus kinase inhibitor (1)
- jet energy scale (1)
- jet production (1)
- jets (1)
- joint-action (1)
- josephson junction (1)
- judgements (1)
- judgments (1)
- jump height (1)
- juvenile idiopathic arthritis (1)
- juvenile myoclonic epilepsy (1)
- kallikrein-kinin system (1)
- kappa-B (1)
- kdm6a (1)
- keloids (1)
- key innovation (1)
- kidney function (1)
- kinase inhibitor (1)
- kinesin (1)
- kinetische Plasmaphysik (1)
- klassische Zeit (1)
- knockout mice (1)
- knowledge engineering (1)
- kognitive Beeinträchtigung (1)
- kognitive Defizite (1)
- kognitive Remediation (1)
- kognitive Semantik (1)
- konische Durchschneidung (1)
- korrupte Organisationskultur (1)
- kritisch-kranke Patienten (1)
- land use intensification (1)
- land-atmosphere interaction (1)
- land-cover classification (1)
- land-use intensity (1)
- landscape ecology (1)
- large gene lists (1)
- large-scale climate circulation (1)
- late positive potential (1)
- lateral geniculate-nucleus (1)
- lattice (1)
- lead-lead collision (1)
- learned helplessness (1)
- learning (1)
- learning-by-doing (1)
- lectotype (1)
- left lateral wall (1)
- left ventricular hypertrophy (1)
- leishmania (1)
- leishmaniasis (1)
- length (1)
- lepton flavour violation (1)
- leukemia (1)
- leukocytes (1)
- level mechanical vibrations (1)
- lexical decision task (1)
- life expectancy (1)
- life history (1)
- life span (1)
- ligand (1)
- ligand CD55 (1)
- ligand potencies (1)
- ligand-receptor complex (1)
- ligation (1)
- limited mobility (1)
- line (1)
- linear combination (1)
- linguistic markedness (1)
- linkage analysis (1)
- linkage map (1)
- lipid bilayer membranes (1)
- listeria monocytogenes (1)
- literary studies (1)
- liver microsomes (1)
- local density (1)
- local supersymmetry (1)
- localization (1)
- localized wannier functions (1)
- loci (1)
- locked-in state (1)
- long noncoding RNA (1)
- long term examination (1)
- long-distance dispersal (1)
- long-lived neutral particle (1)
- long-term potentation (1)
- long-term potentiation (1)
- loop B (1)
- loop region (1)
- low intensity (1)
- lowering lattice forces (1)
- luciferase (1)
- luminescence based detectors (1)
- luminescence crystal structure (1)
- lumineszenzbasierte Detektoren (1)
- lung (1)
- lungenprotektive Beatmung (1)
- lymphadenitis (1)
- lymphocytes (1)
- lymphokine-activated killer (1)
- lysine biosynthesis (1)
- mRNA metabolism (1)
- mRNA-Seq (1)
- magnetic field relaxation (1)
- magnetic-resonance behavior (1)
- magnitude (1)
- maintain immune homeostasis (1)
- maize (1)
- major depression (1)
- major depressive disorder (1)
- major histocompatibility complex (1)
- male-specific traits (1)
- males (1)
- males emerge (1)
- malignancies (1)
- malignant lymphoma (1)
- malignant melanoma (1)
- man-portable mapping (1)
- managed grasslands (1)
- manganese (1)
- mangrove ecosystems (1)
- mapping (1)
- marine Synechococcus strains (1)
- marrow (1)
- masked priming (1)
- mass (1)
- mass vaccination (1)
- match-mismatch (1)
- materials design (1)
- maternal care (1)
- mating success (1)
- matrix metalloproteinases (1)
- matrix protein porin (1)
- maximum oxygen uptake (1)
- maximum power (1)
- mean-field theory (1)
- mechanical properties (1)
- mechanical stiffness (1)
- mechanical thrombectomy stroke (1)
- mechanische Steifigkeit (1)
- mechanische Thrombektomie (1)
- mechanism (1)
- mechanisms retention (1)
- medial temporal lobe (1)
- medical Education (1)
- medical complications (1)
- medical hypoxia (1)
- medical physics (1)
- medical rehabilitation (1)
- medicine (1)
- medullary thyroid cancer (1)
- mekong delta (1)
- melanin (1)
- melanocytes (1)
- melanocytic nevi (1)
- melanogenesis (1)
- melanoma cancer (1)
- melanoma patients (1)
- melanomas (1)
- mellitus (1)
- membrane (1)
- membrane potential (1)
- membrane receptor signaling (1)
- membrane repair (1)
- membrane vesicles (1)
- memoria (1)
- memory B cell (1)
- memory B cells (1)
- memory cells (1)
- memory deficits (1)
- memory formation (1)
- memory immune responses (1)
- men born (1)
- mental representation (1)
- mepacrine (1)
- mercury (1)
- mere exposure (1)
- merozoite (1)
- mesoscopic physics (1)
- mesoskopische Physik (1)
- messenger-RNA (1)
- messenger-RNA transport (1)
- metabolites (1)
- metabolomics (1)
- metachronous (1)
- metacognitive prompting (1)
- metagenomic (1)
- metal carbonyl (1)
- metal surfaces (1)
- metal-insulator transition (1)
- metal-organic framework (1)
- metal-organic frameworks (1)
- metallo-polyelectrolytes (1)
- metallosupramolecular π-amphiphiles (1)
- metaphors (1)
- metastasis (1)
- metastatic melanoma (1)
- methionine pet (1)
- methotrexate (1)
- mfVEP (1)
- mfg-e8 (1)
- mhc molecules (1)
- miR-122 (1)
- miR-181 (1)
- miRNAs (1)
- mice impact (1)
- micelle (1)
- micro-photoluminescence (1)
- microRNA (1)
- microbial communities (1)
- microbial rhodopsins (1)
- microcephalin 1 (1)
- microelectrodes (1)
- microfluidic chip (1)
- microglia (1)
- microglial cells (1)
- micromorphologie (1)
- microneme (1)
- microscopy (1)
- microsphere/macrosphere (1)
- microstructure (1)
- microstructures (1)
- microvascular complications (1)
- mid-infrared (1)
- migraine (1)
- migration (1)
- mimicry (1)
- mineral metabolism (1)
- mineralization (1)
- mismatch recognition (1)
- missense (1)
- mitochondrial biogenesis (1)
- mitochondrial membrane (1)
- mitochondrial transport (1)
- mitogenic signaling (1)
- mitomycin C (1)
- mitosis (1)
- mixed fiber neuropathy (1)
- mixed mutation mechanisms (1)
- miyoshi myopathy (1)
- mobile laser scanning (1)
- mobility (1)
- mode (1)
- model Bessel function (1)
- model calculation (1)
- moderating role (1)
- moderation (1)
- modifiers (1)
- modulates virulence (1)
- mold disease (1)
- molecular analysis (1)
- molecular basis (1)
- molecular characterization (1)
- molecular cloning (1)
- molecular data (1)
- molecular docking (1)
- molecular liphophilicity potential (1)
- molecular mechanisms (1)
- molecules (1)
- monkey striate cortex (1)
- mono-temporal image (1)
- monoclonal antibodies (1)
- monoclonal antibody (1)
- monomethyl fumarate (1)
- monoubiquitination (1)
- months follow-up (1)
- mood (1)
- morphogenetic furrow progression (1)
- morphometry (1)
- morris water maze (1)
- mortality rates (1)
- mothers (1)
- moths and butterflies (1)
- motif discovery (1)
- motifs (1)
- motoneuron (1)
- motor axons (1)
- motor cortex activation (1)
- motor imagery technology (1)
- motor-impaired end-user (1)
- mott insulator (1)
- mouse (1)
- mouse brain (1)
- mouse lymphoma L5178Y (1)
- mouse testis differentiation (1)
- mrsk2 KO mouse (1)
- multi scale heterogeneity (1)
- multi-electrode-recording (1)
- multi-temporal images (1)
- multidetector computed-tomography (1)
- multilocularis (1)
- multimedia, (1)
- multiparametric flow cytometry (1)
- multiparticle collision dynamics (1)
- multiple diseases (1)
- multiple-sclerosis (1)
- multiply connected domain (1)
- multitemporal ALOS/PALSAR imagery (1)
- multivariate Entscheidungsverfahren (1)
- multiwalled carbon nanotube (1)
- murine model (1)
- musculus temporalis (1)
- mutagenicity (1)
- mutants (1)
- mutation (1)
- mutual information (1)
- myocarditis (1)
- mémoire (1)
- nanoactivity (1)
- nanodiamond (1)
- nanolithography (1)
- nanostructures (1)
- nanotube-polymer-complexes (1)
- nanowire (1)
- native bees (1)
- natriuretic peptide levels (1)
- natural enemies (1)
- natural history (1)
- natural products (1)
- natural variation (1)
- navigation (1)
- near-field monitoring (1)
- neck cancer (1)
- necrosis factor alpha (1)
- nectar (1)
- negative affect (1)
- nemo tenetur-Grundsatz (1)
- neoblast (1)
- nesting behaviour (1)
- network (1)
- network inference (1)
- networks (1)
- neural mechanisms (1)
- neural response (1)
- neural stem cell (1)
- neuregulin-1 (1)
- neurite outgrowth (1)
- neurodegeneration (1)
- neurodevelopmental disorders (1)
- neurogenesis (1)
- neuron navigator 3 (1)
- neurons (1)
- neuropathy (1)
- neuroprotection (1)
- neutralino (1)
- neutron star (1)
- neutropenic fever (1)
- new media (1)
- new physics (1)
- new species (1)
- newly-diagnosed myeloma (1)
- niche (1)
- nicht syndromale Spaltbildung (1)
- nicht-diagonale langreichweitige Ordnung (1)
- nicht-unschuldiges Ligandverhalten (1)
- nicotinamide phosphoribosyltransferase (1)
- nicotine addiction (1)
- nociceptors (1)
- nomenclature (1)
- non-VKA oral anticoagulants (1)
- non-covalent interactions (1)
- non-penetrating glaucoma surgery (1)
- nonautonomous (1)
- nonconscious mimicry (1)
- nonhuman-primates (1)
- nonneuronal acetylcholine (1)
- nontraumatic osteonecrosis of the femoral head (1)
- normal distribution (1)
- norway spruce (1)
- nosocomial infection (1)
- nosocomial pathogen (1)
- novel nepetolactone derivative (1)
- novo renal transplantation (1)
- nuclear cardiology (1)
- nuclear envelope (1)
- nuclear magnetic resonance (1)
- nuclear medicine (1)
- nuclear pore complex (1)
- nucleo-cytoplasmic (1)
- nucleotide-gated channel (1)
- nucleus (1)
- nucleus ventralis intermedius (1)
- number (1)
- numerical cognition (1)
- nutrition (1)
- nutzerzentrierter Ansatz (1)
- obesity (1)
- obstacle detection (1)
- obstructive pulmonary disease (1)
- occupational-status (1)
- ocular dominance columns (1)
- odorants (1)
- oilseed rape (1)
- olfactory bulb (1)
- oligo(phenylene ethynylene) (OPE) (1)
- oligomers (1)
- on-a-chip (1)
- oncogene amplification (1)
- oncogene-induced senescence (1)
- oncogenes (1)
- oncolysis (1)
- oncolytic virotherapy (1)
- oncolytic virus (1)
- oncolytic virus therapy (1)
- onkolytische Virustherapie (1)
- online advertising (1)
- open-access database (1)
- open-angle glaucoma (1)
- opioid receptors (1)
- opossum kidney cells (1)
- optical control (1)
- optical lattice (1)
- optical reconstruction microscopy (1)
- optical spectroscopy (1)
- optimal control (1)
- optimize performance (1)
- oragnoids (1)
- oral anticoagulant therapy (1)
- oral mucositis (1)
- orale Antikoagulationstherapie (1)
- orale Bioverfügbarkeit (1)
- organic solar cell (1)
- organic thin films (1)
- organic transistor (1)
- organisationale Korruption (1)
- organische Solarzelle (1)
- organischer Transitor (1)
- organismal evolution (1)
- organization (1)
- organizational corruption (1)
- orientation columns (1)
- orientational patterns (1)
- orthoptera (1)
- oscillations (1)
- osmia (1)
- osteoblastic cells (1)
- osteogenic differentiation (1)
- osteopontin (1)
- outer membrane proteins (1)
- ovarian cancer (1)
- ovarian carcinoma (1)
- ovariectomized rats (1)
- overdose (1)
- overexpression (1)
- oxygen (1)
- oxygen-glucose deprivation (1)
- p38 (1)
- p38 mitogen-activated protein kinase (1)
- p53 (1)
- paddy (1)
- paddy rice (1)
- pain (1)
- pain questionnaire (1)
- pain-related evoked potentials (1)
- painful (1)
- pair production (1)
- pallidal stimulation (1)
- palynolog (1)
- pancreatic cancer (1)
- panic disorder (1)
- papillary (1)
- papyrus collection Bremen (1)
- papyrus collection Gießen (1)
- paragangliomas (1)
- parasite (1)
- parasites (1)
- parasitic diseases (1)
- parasitic plants (1)
- parathyroid hormone (1)
- paravalvular regurgitation (1)
- parenting stress (1)
- parietal pleurectomy (1)
- parity (1)
- parkinsons disease (1)
- paromomycin (1)
- paroxysmal atrial fibrillation (1)
- partial differetial equations (1)
- particle (1)
- patch connectivity (1)
- pathogen (1)
- pathogen vacuole (1)
- pathogen-host interaction (PHI) (1)
- pathology (1)
- pathology section (1)
- patient survival (1)
- patientenspezifische Implantate (1)
- pattern onset VEP (1)
- pattern-pulse (1)
- pediatric surgery (1)
- peginterferon alpha-2b (1)
- penalty throw (1)
- pentacene (1)
- performance liquid chromatography (1)
- perfusion (1)
- perioperative chemotherapy (1)
- peripheral blood lymphocytes (1)
- peripheral nerve injury (1)
- peripheral nervous system (1)
- peritoneal carcinomatosis (1)
- permanent and transient middle cerebral artery occlusion (1)
- permutation (1)
- peroral endoscopic myotomy (1)
- peroxiredoxin 6 (1)
- persistence (1)
- persister cells (1)
- personal laser scanning (1)
- perylene bisimide (1)
- pest (1)
- pestis infection (1)
- ph (1)
- phacocanaloplasty (1)
- phacotrabeculectomy (1)
- phagosome maturation arrest (1)
- pharmaceutical analysis (1)
- pharmaceutical applications (1)
- pharmacokinetic (1)
- pharmacokinetic interaction (1)
- pharmacokinetics (1)
- pharmacology (1)
- phase transitions (1)
- phenolic constituents (1)
- phenology shifts (1)
- phenotypic heterogeneity (1)
- phenotypic plasticity (1)
- pheromones (1)
- phobia (1)
- phonation (1)
- phonetic symbolism (1)
- phosphatase 2A (1)
- phosphate homeostasis (1)
- phosphatidic acid (1)
- phosphatidylinositol 3-kinase/Akt (1)
- phosphodiesterase (1)
- phospholipase D (1)
- phosphorus (1)
- phosphorylated glycogen synthase kinase-3beta (pGSK-3beta) (1)
- photodynamic therapy (1)
- photoelectron spectroscopy (1)
- photoelectron-photoion coincidence (1)
- photoemission (1)
- photoemission spectroscopy (1)
- photoinduced electron transfer (1)
- photoinduzierter Elektronentransfer (1)
- photoluminescence (1)
- photonic devices (1)
- photothrombosis (1)
- physical activity (1)
- physics transition (1)
- physiological characteristics (1)
- physiological constraints (1)
- phytochemistry (1)
- phytomedicine (1)
- phytoneering (1)
- placental mammal (1)
- plant cells (1)
- plant diversity (1)
- plant immunity (1)
- plant species richness (1)
- plant-insect interactions (1)
- plant-made vaccines (1)
- plant-plant interaction (1)
- plantations (1)
- plasma clearance (1)
- plasticity (1)
- plastid targeting (1)
- platelet activation (1)
- platelet aggregation (1)
- platelets (1)
- plumes (1)
- pluripotency (1)
- plus dexamethasone (1)
- pneumonia (1)
- pneumonic plague (1)
- podophyllotoxin (1)
- poeciliid fishes (1)
- point labeling (1)
- point-of-care test (1)
- polarimetric SAR (1)
- polarimetry (1)
- polarization pulse shaping (1)
- polarized training (1)
- polisübergreifende Beziehungen (1)
- political leaders (1)
- politics (1)
- politische Entscheidungsfindung (1)
- pollen (1)
- pollination (1)
- pollination ecology (1)
- pollution (1)
- poly(A) site usage (1)
- polyacrylic acid (1)
- polyamine (1)
- polyethylenglykole (1)
- polylactid (1)
- polymer (1)
- polymerization (1)
- polymorphisms inflammation (1)
- polymyositis (1)
- polyploidization (1)
- polyploidy (1)
- pomalidomide (1)
- pooled (1)
- poorly water soluble (1)
- poorly water soluble drugs (1)
- popular sports (1)
- population (1)
- populations (1)
- populations genetics (1)
- porosity (1)
- porous (1)
- porös (1)
- posaconazole (1)
- positive emotions (1)
- positive interneurons (1)
- positron-emission-tomography (1)
- post-pandemic (1)
- posterior parietal cortex (1)
- postoperative care (1)
- postoperative complications (1)
- postsurgical adhesion (1)
- potassium channels (1)
- potent (1)
- potent inducer (1)
- potential role (1)
- potentially bleeding pathologies (1)
- power-station accident (1)
- pre-messenger RNA (1)
- predictive adaptive response hypothesis (1)
- preexisting bias (1)
- preference construction (1)
- prefrontal activity (1)
- prefrontal cortex (1)
- premalignant lesion (1)
- preproteins (1)
- presence (1)
- presence questionnaire (1)
- pressure otimum (1)
- presynaptic calcium (1)
- presynaptic differentiation (1)
- pretension (1)
- preterm birth (1)
- prevention (1)
- primary cells (1)
- primary microvascular endothelial cells (1)
- primary prophylaxis (1)
- priming (1)
- principal component analysis (1)
- process analysis (1)
- process mining (1)
- processing bias (1)
- productivity (1)
- prognosis (1)
- prognostic marker (1)
- promastigotes (1)
- promoter (1)
- promoter methylation (1)
- promoting girls (1)
- proportion of seminatural habitat (1)
- propranolol (1)
- propriozeptive Defizit (1)
- propriozeptive Training (1)
- propulsion (1)
- prospective (1)
- prospective feasibility (1)
- prospective randomized trial (1)
- prostaglandin E2 (1)
- prostaglandin e2 (1)
- prostate cancer (1)
- protandry (1)
- protease (1)
- protease activity (1)
- protein RSK2 (1)
- protein biomarkers (1)
- protein biosynthesis & quality control (1)
- protein complexes (1)
- protein coupled receptors (1)
- protein domains (1)
- protein expression (1)
- protein interaction database (1)
- protein interactions (1)
- protein-1 CDMP1 gene (1)
- protein-protein interaction (1)
- protein-protein interaction network (1)
- proteinuria (1)
- proton MRI (1)
- proton efflux (1)
- proton-lead collision (1)
- proton-proton collisions (1)
- proton-proton-collisions (1)
- proton-proton-collistion (1)
- proton-prton-collision (1)
- proximity effect (1)
- pseudomas aeruginosa (1)
- pseudomonas aeruginosa (1)
- psoriasis (1)
- psychological stress (1)
- psychophysiology (1)
- psychosocial stress (1)
- psychosozialer Stress (1)
- public speaking (1)
- pulmonary (1)
- pulmonary drug-delivery (1)
- pulmonary hypertension (1)
- pulmonary wedge resection (1)
- pulsating explosive eruptions (1)
- punishment (1)
- purification (1)
- pyramidal retrospective (1)
- pyridobenzodiazepine (1)
- pyrolysis (1)
- pädiatrische Onkologie (1)
- quadrocopter (1)
- quadrotor (1)
- qualitative Sozialforschung (1)
- quality of life (1)
- quantification (1)
- quantitative computed tomography (1)
- quantitative remote sensing (1)
- quantitative sensory testing (1)
- quantum dot (1)
- quantum dot systems (1)
- quantum gases (1)
- quantum point contact (1)
- quasi-continuum (1)
- qubits (1)
- quinacrine (1)
- radar (1)
- radiation (1)
- radiation myelitis (1)
- radiation therapy (1)
- radical prostatectomy (1)
- radio astronomy (1)
- radionuclide therapy (1)
- radiotracer (1)
- rainforest (1)
- raltegravir (1)
- ramp test (1)
- random walk (1)
- rapid BCI (1)
- rare (1)
- rare earth chlorides (1)
- rat brain microvascular endothelial cell culture (1)
- rational model (1)
- rats (1)
- re-annotation (1)
- reaction-time tasks (1)
- reactive intermediates (1)
- reactive oxygen (1)
- reactive oxygen species (1)
- real time PCR (1)
- reappraisal (1)
- rebate systems (1)
- receptor (1)
- receptor antagonist (1)
- recognition memory (1)
- recognize images (1)
- recombinant protein rVE (1)
- recombinant proteins (1)
- recombinant-human-erythropoietin (1)
- reconstructed human epidermis (1)
- reconstruction microscopy (1)
- reconstruction plates (1)
- rectal cancer (1)
- recurrence (1)
- recurrence survival (1)
- recurrent Tako-Tsubo cardiomyopathy (1)
- recurrent primary pneumothorax (1)
- red fluorescent protein (1)
- redispergierte Nanopartikel-Sole (1)
- redispersed nanoparticle sol (1)
- reference values (1)
- reflex (1)
- regeneration (1)
- regenerative medicine (1)
- regional analgesia (1)
- regional development (1)
- regional economic circulation (1)
- regional labeling (1)
- register (1)
- registries (1)
- regulation of expression (1)
- regulation strategies (1)
- regulatorische T-Zellen (1)
- regulatory networks (1)
- regulatory protein ICP27 (1)
- regurgitation (1)
- relapsing multiple sclerosis (1)
- relapsing-remitting multiple sclerosis (1)
- relaxation (physics) (1)
- relaxation time (1)
- reliability (1)
- religion (1)
- religious structures (1)
- remote (1)
- remyelination (1)
- renal function (1)
- renal replacement therapy (1)
- repeated dose (1)
- reperfusion (1)
- replacement therapy (1)
- replication (1)
- reporter gen assay (1)
- residence time (1)
- resilience (1)
- resin (1)
- resistant Staphylococcus-aureus (1)
- resistant acid phosphatase (1)
- resolution (1)
- resonances (1)
- resonant inelastic x-ray scattering (1)
- resonant photoelectron spectroscopy (1)
- resource (1)
- respiratory distress syndrome (1)
- respiratory syncytial virus (1)
- response evaluation (1)
- response inhibition (1)
- response priming (1)
- response regulator (1)
- responses (1)
- retinal differentiation (1)
- retrotransposition (1)
- revealed preference (1)
- reverse Transkription (1)
- reverse transcription (1)
- reward (1)
- rhabdomyosarcoma (1)
- rheumatoid arthritis (1)
- rhodopsin (1)
- riboflavin (1)
- ribosomal RNA (1)
- ribosomal RNA genes (1)
- ribosome (1)
- rice (1)
- rice mapping (1)
- right-oriented bias (1)
- ringsubstituierte Sandwichverbindungen/ ring-substitueted sadnwich compounds (1)
- riociguat (1)
- risk profiling (1)
- rivers (1)
- room temperature (1)
- root (1)
- runoff (1)
- rural structures (1)
- régénération (1)
- s allele (1)
- s-Channel (1)
- salt solutions (1)
- sand dynamics (1)
- scanning tunneling spectroscopy (1)
- scars (1)
- schistosoma (1)
- schistosomula (1)
- schwer wasserlöslich (1)
- sciatic nerve (1)
- search filter (1)
- second-order correlation function (1)
- secondary metabolite gene cluster (1)
- secondary metabolites (1)
- secondary prevention (1)
- secondary rainforest fragments (1)
- secretion systems (1)
- selective channel (1)
- self (1)
- self-assembly (1)
- self-diffusion (1)
- self-efficacy (1)
- self-focused attention (1)
- self-organized magnetization (1)
- self‐regulated learning (1)
- semiconductor (1)
- semiconductor interfaces (1)
- semiconductor quantum dots (1)
- senescence (1)
- sensitive amine oxidase (1)
- sensitivity (1)
- sequence alignment (1)
- sequence analysis (1)
- sequencing data (1)
- series (1)
- seroprevalence (1)
- serotonin (1)
- serotonin transporter gene (1)
- serovar Typhimurium (1)
- serum 25-hydroxyvitamin D (1)
- serum amyloid A (1)
- serum concentrations (1)
- serum creatinine (1)
- sevoflurane (1)
- sex combs (1)
- sex differentiation (1)
- sexual stage (1)
- shaping of porosity (1)
- shear stress (1)
- sheep (1)
- shootin-1 (1)
- short-term-memory (1)
- siRNA (1)
- siRNAs (1)
- sick leave (1)
- side chain properties (1)
- signal transduction (1)
- signal transduction pathway (1)
- signaling pathways (1)
- signalling (1)
- signals (1)
- signature (1)
- siliciumorganische Wirkstoffe (1)
- silk fibroin (1)
- similarity (1)
- simple receptive-fields (1)
- simulation (1)
- simultaneous (1)
- single cell (1)
- single particle tracking (1)
- single photon (1)
- single subject (1)
- single-crystalline Ru surfaces (1)
- single-nucleotide polymorphisms (1)
- single-top-quarks (1)
- single-trial EEG classification (1)
- sinorhizobium fredii NGR234 (1)
- site (1)
- situation of women (1)
- size dimorphism (1)
- size exclusion chromatography (1)
- skeletal-muscle (1)
- skin autofluorescence (1)
- skin conductance response (1)
- skin fatty acid (1)
- skin hemagioma (1)
- skin reactions (1)
- skull base (1)
- sleep EEG (1)
- sleeping sickness (1)
- small RNAs (1)
- small bowel MRI (1)
- small regulatory RNAs (1)
- small-colony variants (1)
- smoking motives (1)
- snails (1)
- social anxiety (1)
- social influence (1)
- social interaction (1)
- social network sites (1)
- social phobia (1)
- sodium channels (1)
- sofosbuvir (1)
- software (1)
- soil moisture retrieval (1)
- sol (1)
- sol gel (1)
- solid dispersion (1)
- solid state (1)
- solid tumors (1)
- somatic mosaicism (1)
- somatic mutations (1)
- somatostatin (1)
- sorption studies (1)
- sound symbolism (1)
- source parameters (1)
- sozialversicherungspflichtige Beschäftigung (1)
- space (1)
- spacer sequences (1)
- spanish literature (1)
- spatial filters movement (1)
- spatial modelling (1)
- spatial navigation (1)
- spatial numerical associations (1)
- spatial risk profiling (1)
- spatially resolved photoluminescence (1)
- specialization (1)
- species richness (1)
- specificity (1)
- spectrometry-based proteomics (1)
- spectroscopy (1)
- spectrum (1)
- speech anxiety (1)
- speed skaters (1)
- speller performance (1)
- sperm head formation (1)
- spermatogenesis (1)
- spermine (1)
- spermiogenesis (1)
- spider phobia (1)
- spillover (1)
- spin chemistry (1)
- spin structures (1)
- spin-orbit coupling (1)
- spinal cord (1)
- spinal-cord (1)
- spinco ultracentrifuge (1)
- spinpolarized scanning tunneling microscopy, temperature dependent phase transitions (1)
- spire (1)
- splicing inhibition (1)
- spondyloenchondrodysplasia (1)
- sponges (1)
- spontaneously hypertensive rat (1)
- spores (1)
- spot size (1)
- squaraine polymer (1)
- stage III (1)
- standard (1)
- standard model (1)
- standing wave formation (1)
- staphylococcus aureus (1)
- statistical disperison (1)
- statistics (1)
- steady-state visually evoked potentials (1)
- steered molecular dynamics (1)
- stem cells (1)
- stem-cells (1)
- stem/progenitor cells (1)
- stenosis (1)
- stent retriever stroke (1)
- steps (1)
- stepwatch (1)
- stimuli (1)
- stimulus (1)
- strains (1)
- strategy (1)
- street labeling (1)
- strength (1)
- streptococci (1)
- streptococcus pneumoniae (1)
- streptomyces (1)
- streptozotocin (1)
- stress (1)
- striga (1)
- stroke treatment (1)
- stroke, acute (1)
- stroke-associated pneumonia (1)
- stromal cells (1)
- stroop interference (1)
- structural basis (1)
- structural genome variations (1)
- structural model (1)
- structured illumination (1)
- sub-saharan africa (1)
- subcutaneous injection (1)
- subsequent memory (1)
- substratal idiothetic navigation (1)
- substrate quality (1)
- substrate recognition (1)
- subtalar (1)
- subthreshold IKK activation (1)
- subtilis genome (1)
- subtypes (1)
- sucrose (1)
- suicide attempt (1)
- superconductivity (1)
- superfluid (1)
- supergauge transformations (1)
- supersymmetry (1)
- supramolekulare Farbstoffchemie (1)
- surface (1)
- surface states (1)
- surface water (1)
- surfactants (1)
- surgical outcomes (1)
- surgical treatment (1)
- surprise (1)
- susceptibility loci (1)
- sustainable intensification (1)
- sustainable regional development (1)
- suture (1)
- swordtails (1)
- symbiosis (1)
- synapse (1)
- synaptic delay (1)
- synaptic transmission (1)
- synaptotagmin (1)
- syndromale Spaltbildung (1)
- synergistic reinforcement (1)
- syntaktische Funktion (1)
- syntaktische Struktur (1)
- syntax (1)
- syphilis (1)
- system bcg (1)
- systematic review (1)
- systemic candidiasis (1)
- systemic lupus erythematosus (1)
- systemic risk (1)
- systems (1)
- t-Test (1)
- tDCS (1)
- tag based (1)
- tag fusion proteins (1)
- tapers (1)
- target (1)
- targets (1)
- taste receptor cells (1)
- tau leptons (1)
- teaching hospital (1)
- team sports (1)
- team-training (1)
- tegument protein pUL36 (1)
- telemedicine (1)
- teleostei (1)
- telluride (1)
- temperature dependence (1)
- temporal bone (1)
- tendon (1)
- tenofovir disaproxil fumarate (1)
- term follow-up (1)
- theatre (1)
- theoretical chemistry (1)
- theory of event coding (1)
- therapeutic drug monitoring (1)
- therapeutic target (1)
- thermal conductivity (1)
- thermal gating (1)
- thermal treatment (1)
- thermodynamics (1)
- thermoelectrics (1)
- thermopower (1)
- thiazole (1)
- thin film (1)
- thin-film transistors (1)
- think‐aloud data (1)
- third molar surgery (1)
- threat learning (1)
- threat-related stimuli (1)
- three terminal device (1)
- threshold training (1)
- thrombin (1)
- thrombocytopenia (1)
- thromboembolic clot model (1)
- thromboembolic stroke (1)
- thromboinflammation (1)
- thrombolysis (1)
- thymectomy (1)
- thymyl cinnamate (1)
- thyroid cancer (1)
- time inhomogeneities (1)
- time trends (1)
- time-resolved photoluminescence (1)
- time-series (1)
- tolbutamide substrate (1)
- tolerance (1)
- toll-like receptor (1)
- toll-like receptor 2 (1)
- tomato (1)
- tomography (1)
- tonicity (1)
- tool (1)
- top quark (1)
- top quark mass (1)
- top quarks (1)
- top-down control (1)
- top-quark (1)
- top-quark mass (1)
- topical treatment (1)
- topographic aspect (1)
- topological (1)
- topologische Isolatoren (1)
- total energy calculations (1)
- toxicity testing (1)
- toxin (1)
- trabeculectomy (1)
- trafficking (1)
- transaction utility (1)
- transcapillary pressure gradient (1)
- transcription start site (1)
- transcriptional landscape (1)
- transcriptional regulation (1)
- transcriptional responses (1)
- transfer (1)
- transfer dynamics (1)
- transformation (1)
- transforming growth factor-beta-1 (1)
- transgenic mice (1)
- transgenic rats (1)
- transient absorption (1)
- transient ischemic attack (1)
- transition (1)
- translation (1)
- translation initiation (1)
- translational regulation (1)
- translational stroke research (1)
- translocation (1)
- transmission (1)
- transmission electron microscopy (1)
- transplant (1)
- transplantation states genes (1)
- transport (1)
- transport experiments (1)
- transport microenvironments (1)
- transport studies (1)
- transposable elements (1)
- transposition (1)
- transverse energy–energy correlation function (1)
- transverse relaxation (1)
- trap (1)
- treadmill protocol (1)
- treadmill running (1)
- treatment response (1)
- treatment-resistant depression (1)
- tree shrew (1)
- trees (1)
- triceps (1)
- tricuspid pressure gradient (1)
- triplosufficiency (1)
- trophic interactions (1)
- tsetse fly (1)
- tuberculosis (1)
- tuft cells (1)
- tumor biomarker (1)
- tumor cells (1)
- tumor microenvironment (1)
- tumor vascularization (1)
- tumorigenic properties (1)
- tunneling spectroscopy (1)
- turbulence (1)
- turnover (1)
- two-component systems (1)
- type 1 ICP27 (1)
- type I interferonopathy (1)
- type II GaIn(As)Sb/GaSb (1)
- type II quantum wells (1)
- type-1 (1)
- ubiquitin (1)
- ubiquitination (1)
- ulfobutylether-\(\beta\)-cyclodextrin (1)
- ultracold (1)
- ultrasonic autonomous aerial vehicles (1)
- ultraviolet-a (1)
- umbilical hernia (1)
- uncanny valley hypothesis (1)
- unconscious processing (1)
- unconventional superconductivity (1)
- undamaged DNA (1)
- understaffed (1)
- up-conversion (1)
- up-regulation (1)
- upcyte hepatocytes (1)
- upper gastrointestinal tract (1)
- uracil binding (1)
- urban vegetation (1)
- urine (1)
- usability (1)
- user-centred design (1)
- user-generated content (1)
- utaneous adverse events (1)
- utility (1)
- vacancies (1)
- vaccination program (1)
- vaccines (1)
- vacuoles (1)
- valence (1)
- valency (1)
- valtrates (1)
- value chain (1)
- valve replacement (1)
- variation (1)
- vascular adhesion protein-1 (1)
- vascular normalization (1)
- vascular permeability (1)
- vector-field control (1)
- vector-field shaper (1)
- velocity (1)
- verbal fluency tasc (1)
- verdunstungsinduzierter Selbstanordnung (1)
- vertical agreements (1)
- vertical transmission (1)
- vesicle-based barrier (1)
- vesicles (1)
- vesicular acetylcholine transporter (1)
- viability (1)
- viral replication (1)
- virale Mehrfachinfektion (1)
- virtual patients (1)
- virtual reality (1)
- visfatin (1)
- visfatin levels (1)
- vision (1)
- visualization (1)
- vitamin K antagonists (1)
- volcanic eruption (1)
- volcano (1)
- volume regulation (1)
- voluntary movement (1)
- von Willebrand factor (1)
- vulnerability (1)
- warfarin (1)
- warfarin polymorphisms (1)
- wave basis set (1)
- wave functions (1)
- wave superconductors (1)
- weak ferromagnetism (1)
- web server (1)
- weed dodder (1)
- weibliche Lebensführung (1)
- wheat-varieties (1)
- white (1)
- white matter (1)
- whole blood specimens (1)
- whole body MRI (1)
- whole body vibration (1)
- whole-body (1)
- whole-body vibration (1)
- wildlife consumption (1)
- wissenschaftlicher Nachwuchs (1)
- women (1)
- working memory (1)
- world championships (1)
- wound irrigation (1)
- wrath (1)
- x-ray emission (1)
- xanthomonas maltophilia (1)
- yeast telomerase (1)
- zoledonic acid (1)
- zoonotic (1)
- § 1901a BGB (1)
- § 1901b BGB (1)
- Öffentliche Aufträge (1)
- Ösophago-gastro-duodenoskopie (1)
- Ösophaguskarzinom (1)
- Österreichisches Vergaberecht (1)
- Überbrückte Verbindungen (1)
- Übergangsmetall (1)
- Übergangsmetall-Borverbindungen (1)
- Übergangsmetalldichalkogenide (1)
- Übergitter (1)
- Überleben (1)
- Übersetzung (1)
- Überwachungstechnik (1)
- Übung (1)
- α‑Tricalciumphosphat (1)
- β1 integrin (1)
- √s=8 TeV (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (98)
- Physikalisches Institut (87)
- Universität - Fakultätsübergreifend (46)
- Graduate School of Life Sciences (45)
- Neuphilologisches Institut - Moderne Fremdsprachen (36)
- Medizinische Klinik und Poliklinik I (34)
- Institut für Psychologie (32)
- Medizinische Klinik und Poliklinik II (32)
- Neurologische Klinik und Poliklinik (29)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (26)
Schriftenreihe
Sonstige beteiligte Institutionen
- ATLAS Collaboration (1)
- Adam Opel AG (1)
- Bayerische Museumsakademie (1)
- Bayerisches Zentrum für Angewandte Energieforschung e.V. (1)
- Bezirk Unterfranken (1)
- Brown University (1)
- CERN (1)
- Center for Nanosystems Chemistry (CNC), Universität Würzburg, Am Hubland, 97074 Würzburg, Germany (1)
- Deutscher Akademischer Austauschdienst (DAAD) (1)
- Deutsches Zentrum für Luft- und Raumfahrt (DLR), Institut für Raumfahrtsysteme (1)
ResearcherID
- B-1911-2015 (1)
- C-2593-2016 (1)
- D-1221-2009 (1)
- N-2030-2015 (1)
- N-3741-2015 (1)
No abstract available.
3D visualization of movements can amplify motor cortex activation during subsequent motor imagery
(2015)
A repetitive movement practice by motor imagery (MI) can influence motor cortical excitability in the electroencephalogram (EEG). This study investigated if a realistic visualization in 3D of upper and lower limb movements can amplify motor related potentials during subsequent MI. We hypothesized that a richer sensory visualization might be more effective during instrumental conditioning, resulting in a more pronounced event related desynchronization (ERD) of the upper alpha band (10–12 Hz) over the sensorimotor cortices thereby potentially improving MI based brain-computer interface (BCI) protocols for motor rehabilitation. The results show a strong increase of the characteristic patterns of ERD of the upper alpha band components for left and right limb MI present over the sensorimotor areas in both visualization conditions. Overall, significant differences were observed as a function of visualization modality (VM; 2D vs. 3D). The largest upper alpha band power decrease was obtained during MI after a 3-dimensional visualization. In total in 12 out of 20 tasks the end-user of the 3D visualization group showed an enhanced upper alpha ERD relative to 2D VM group, with statistical significance in nine tasks.With a realistic visualization of the limb movements, we tried to increase motor cortex activation during subsequent MI. The feedback and the feedback environment should be inherently motivating and relevant for the learner and should have an appeal of novelty, real-world relevance or aesthetic value (Ryan and Deci, 2000; Merrill, 2007). Realistic visual feedback, consistent with the participant’s MI, might be helpful for accomplishing successful MI and the use of such feedback may assist in making BCI a more natural interface for MI based BCI rehabilitation.
3d-Übergangsmetallphthalocyanin-Moleküle auf Metalloberflächen: Der Einfluss der d-Orbitalbesetzung
(2015)
Im Rahmen dieser Dissertation wird die Untersuchung von 3d-Übergangsmetallphthalocyanin- Molekülen (ÜMPc) – quadratisch-planaren organischen Molekülen, welche im Zentrum ein 3d-Übergangsmetallion besitzen – auf metallischen Oberflächen vorgestellt. Der Fokus dieser Arbeit liegt dabei auf dem Einfluss der d-Orbitalbesetzung auf die magnetischen, elektronischen und strukturellen Eigenschaften der adsorbierten Moleküle, die mit Hilfe der Rastertunnelmikroskopie und -spektroskopie charakterisiert wurden. Die gewonnen Ergebnisse werden zum Teil mit theoretischen Berechnungen analysiert und interpretiert.
Die erste Hälfte der experimentellen Auswertung behandelt die Untersuchung dieser Moleküle auf Ag(001) in Hinblick auf die Existenz einer magnetischen Wechselwirkung, bei der ein unkompensiertes magnetisches Moment des Moleküls durch die Substratelektronen abgeschirmt wird. Dieser Effekt wird als Kondo-Abschirmung bezeichnet und erzeugt in der Zustandsdichte des Moleküls eine Resonanz am Fermi-Niveau. Die Messungen zeigen, dass diese Resonanz ausschließlich am Zentralion von MnPc vorgefunden wird, wohingegen sie bei allen anderen 3d-Übergangsmetallphthalocyanin-Molekülen, die eine höhere d-Orbitalbesetzung besitzen, nicht vorhanden ist. Anhand theoretischer Berechnungen kann die Ursache für dieses Verhalten darauf zurückgeführt werden, dass von allen d-Orbitalen einzig das dz2-Orbital mit dem Substrat geeignet hybridisiert, um eine Kondo-Abschirmung zu erzeugen. Da ausschließlich MnPc einen unkompensierten Spin in diesem Orbital besitzt, kann die An- bzw. Abwesenheit
des Kondo-Effekts auf die unterschiedliche Besetzung des dz2-Orbitals zurückgeführt werden. Neben der eben erwähnten Kondo-Resonanz ist bei MnPc ein weiteres Merkmal am Fermi- Niveau überlagert. Durch die Analyse der räumlichen Verteilung, den Vergleich mit anderen Molekülen und der Manipulation des MnPc-Moleküls kann gezeigt werden, dass es sich bei diesem Merkmal um einen d-Orbitalzustand handelt. Die Manipulation des Moleküls durch gezieltes Entfernen von Wasserstoffatomen ermöglicht darüber hinaus die Stärke der Kondo-Abschirmung zu beeinflussen.
In der zweiten Hälfte der experimentellen Auswertung werden Moleküle auf bismutinduzierten Oberflächenlegierungen der Edelmetalle Cu(111) und Ag(111) untersucht. Diese Legierungen zeichnen sich durch einen ausgeprägten Rashba-Effekt aus, der durch eine Aufspaltung der Parabeldispersion und Aufhebung der Spin-Entartung im zweidimensionalen Elektronengas der Oberflächenlegierung charakterisiert ist. Das Wachstumsverhalten von CuPc und MnPc auf diesen Oberflächen zeigt ein sehr gegensätzliches Verhalten. Während bei MnPc die Substrat-Molekül-Wechselwirkung dominant ist, wodurch diese Moleküle immer einen festen Adsorptionsplatz auf der Oberfläche besitzen, ist diese Wechselwirkung bei CuPc schwach ausgeprägt. Aus diesem Grund wandern die CuPc-Moleküle zu den Stufenkanten und bilden Cluster. Das unterschiedliche Wachstumsverhalten der Moleküle lässt sich auf die partiell-gefüllten d-Orbitale von MnPc zurückführen, die aus der Molekülebene ragen, mit dem Substrat hybridisieren und damit das Molekül an das Substrat binden. Bei CuPc hingegen sind diese d-Orbitale gefüllt und die Hybridisierung kann nicht stattfinden.
Im letzten Abschnitt werden die elektronischen und magnetischen Eigenschaften von MnPc auf diesen Substraten behandelt, die einige Besonderheiten aufweisen. So bildet sich durch die Adsorption des Moleküls auf den Oberflächen eine Grenzschichtresonanz aus, die eine partielle Füllung erkennen lässt. Spektroskopiedaten, aufgenommen am Ort der Grenzschichtresonanz, weisen eine symmetrisch um das Fermi-Niveau aufgespaltene Resonanz auf. Die Intensität der unter- und oberhalb der Fermi-Energie befindlichen Resonanz zeigen dabei ein komplementäres Verhalten bzgl. der jeweiligen Lage auf der Grenzschichtresonanz: An den Orten, an denen die Resonanz unterhalb des Fermi-Niveaus ihre maximale Intensität besitzt, ist die Resonanz oberhalb des Fermi-Niveaus nicht vorhanden und umgekehrt. Diese experimentellen Beobachtungen werden mit einem Modellansatz erklärt, welcher die Wirkung eines effektiven Magnetfeldes und eine Spin-Filterung postuliert.
Multiple myeloma (MM) remains an essentially incurable hematologic malignancy. However, new treatment modalities and novel drugs have been introduced and thus additional tools for therapy monitoring are increasingly needed. Therefore, we evaluated the radiotracers \(^{11}\)C-Methionine (paraprotein-biosynthesis) and \(^{18}\)F-FDG (glucose-utilization) for monitoring response to anti-myeloma-therapy and outcome prediction. Influence of proteasome-inhibition on radiotracer-uptake of different MM cell-lines and patient-derived CD138\(^{+}\) plasma cells was analyzed and related to tumor-biology. Mice xenotransplanted with MM. 1S tumors underwent MET- and FDG-\(\mu\)PET. Tumor-to-background ratios before and after 24 h, 8 and 15 days treatment with bortezomib were correlated to survival. Treatment reduced both MET and FDG uptake; changes in tracer-retention correlated with a switch from high to low CD138-expression. In xenotransplanted mice, MET-uptake significantly decreased by 30-79% as early as 24 h after bortezomib injection. No significant differences were detected thus early with FDG. This finding was confirmed in patient-derived MM cells. Importantly, early reduction of MET-but not FDG-uptake correlated with improved survival and reduced tumor burden in mice. Our results suggest that MET is superior to FDG in very early assessment of response to anti-myeloma-therapy. Early changes in MET-uptake have predictive potential regarding response and survival. MET-PET holds promise to individualize therapies in MM in future.
Im Rahmen dieser Arbeit sollten die Möglichkeiten der MR Tomographie erkundet werden bakterielle Infektionen im Zeitverlauf darzustellen. Genauer gesagt sollte das Potential der MR Tomographie anhand eines durch eine Infektion induzierten lokalisierten Abszesses unter Verwendung dreier unterschiedlicher MRT Methoden untersucht werden: Mittels nativem \(T_2\) Kontrast; der Verwendung von superparamagnetischen Eisenoxid Partieln (USPIO) als \(T_2^*\) Kontrastmittel; und dem Einsatz von Perfluorkarbonen (PFC) als \(^{19}F\) MRT Marker (siehe Kapitel 3).
Wie erwartet führte die durch die Infektion hervorgerufene Entzündung zu veränderten \(T_2\)-Zeiten, welche auf \(T_2\)-gewichteten MR Bildern eine Lokalisierung des Abszessbereiches erlauben. Jedoch eigneten sich diese Daten aufgrund der graduellen Änderung der \(T_2\)-Zeiten nicht, um eine klare Grenze zwischen Abszess und umliegendem Gewebe zu ziehen.
Superparamagnetische Eisenoxidpartikel andererseit haben als MRT Kontrastmittel bereits in den letzten Jahren ihre Fähigkeit unter Beweis gestellt Entzündungen [53, 58, 64] darzustellen. Die Anreicherung dieser Partikel am Rande des Abszesses [53], wie sie auch in unseren MR Daten zu beobachten war, erlaubte eine relativ scharfe Abgrenzung gegenüber dem umgebenden Gewebe in der chronischen Phase der Infektion (Tag 9 p.i.). Hingegen genügte die nur sehr spärlichen Anreicherung von USPIO Partikeln in der akuten Phase der Infektion (Tag 3 p.i.) nicht für eine entsprechende Abgrenzung [58].
Aufgrund der sehr geringen biologischen Häufigkeit und den sehr kurzen Relaxationszeiten von endogenem Fluor eignen sich Perfluorkarbone als Markersubstanz in der MR Tomographie von biologischen Systemen. Insbesondere da PFC Emulsionen durch phagozytierende Zellen aufgenommen werden und im Bereich von Entzündungen akkumulieren [30, 59]. In dieser Arbeit konnte anhand der erhaltenen MRT Daten eine Akkumulation von Perfluorkarbonen nicht nur in der chronischen Phase, sondern auch in der akuten Phase nachgewiesen werden. Diese Daten erlauben somit zu allen untersuchten Zeitpunkten eine Abgrenzung zwischen Infektion und umliegenden Gewebe.
Aufgrund der besagten Vorteile wurden die Perfluorkarbone gewählt, um die Möglichkeiten der MR Tomographie zu testen, quantitative Informationen über die schwere der Infektion zu liefern. Als Referenz für die Bakterienbelastung wurden die Biolumineszenzbildgebung (BLI) [49, 50] und die Standardmethode zur Bestimmung der Bakterienbelastung cfu (koloniebildenden Einheiten) herangezogen. Eine Gegenüberstellung der zeitlichen Verläufe der durch die Biolumineszenzbildgebung und durch die cfu erhaltenen Daten liefert eine qualitative Übereinstimmung mit den durch die 19F MR Tomographie erhaltenen Daten. Dies trifft hierbei sowohl auf die über den gesamten Infektionsbereich hinweg summierten Signalamplituden, als auch auf das Volumen zu, in dem Fluor am Ort der Infektion akkumuliert wurde. Im Gegensatz zur Methode der cfu Bestimmung sind die MR Tomographie und die Biolumineszenzbildgebung nicht invasiv und erlauben die Verfolgung des Infektionsverlaufes an einem einzelnen Individuum. Hierzu benötigt, im Gegensatz zur MR Tomographie, die Methode der Biolumineszenzbildgebung jedoch einen speziellen Pathogenstamm. Darüber hinaus ist hervorzuheben, dass die MR Tomographie zudem die Möglichkeit bietet auch morphologische Informationen über den Infektionsbereich und seine Umgebung zu akquirieren.
Gerade weil jede dieser Methoden die mit der Infektion einhergehenden Prozesse aus einer leicht anderen Blickrichtung betrachtet, erscheint es sinnvoll diese etablierte Untersuchungsplattform bestehend aus MRT, BLI und cfu über die in dieser Arbeit bearbeitete Fragestellung hinaus näher zu untersuchen. Insbesondere der Aspekt inwieweit die drei Methoden sich gegenseitig ergänzen, könnte einen tieferen Einblick in die Wechselwirkung zwischen Pathogen und Wirt erlauben.
Auch wenn für die betrachtete Fragestellung bereits der hierdurchgeführte semiquanitative Ansatz zur Bestimmung der relativen Fluormengen am Ort der Infektion ausreichte, so ist doch im Allgemeinen wünschenswert probenbezogen die Sensitivität der Spule und damit die Güte der Spulenabstimmung zu bestimmen. Hierzu ist jedoch die Aufnahme von \(B_1\)-Karten unabdingbar und wird entsprechend im Kapitel 4 \(Bloch-Siegert B_1^+-Mapping\) näher addressiert. Der Schwerpunkt liegt hierbei, wie der Kapitelname bereits andeutet, auf der Bloch-Siegert Methode, die insbesondere in der präsentierten Implementierung in einer Turbo/ Multi Spin Echo Sequenz eine effiziente Nutzung der relativ langen \(T_\)2-Zeiten der Perfluorkarbone erlaubt. Da zudem die Bloch-Siegert-Methode eine rein phasenbasierte Methode ist, kann neben der aus den Daten erzeugten \(B_1\)-Karte zugleich ein unverfälschtes Magnitudenbild generiert werden, wodurch eine sehr effiziente Nutzung der vorhandenen Messzeit ermöglicht wird. Diese Eigenschaft ist insbesondere für \(^{19}F\) Bildgebung von besonderem Interesse, da hier für jede Messung, aufgrund der üblicherweise relativ geringen Konzentration an Fluoratomen, lange Messzeiten benötigt werden.
Zusammenfassend konnte anhand des untersuchten Tiermodells sowohl die Fähigkeit der MR Tomographie nachgewiesen werden Infektionen im Zeitverlauf darzustellen, als auch die Fähigkeit der MR Tomographie quantitative Informationen über den Verlauf der Infektion zu liefern. Desweiteren konnte eine Möglichkeit aufgezeigt werden, welche das Potential hat in vertretbarem Zeitrahmen auch in vivo B1+-Karten auf dem Fluorkanal zu erstellen und so einen zentralen Unsicherheitsfaktor, für Relaxometry und absolute Quantifizierung von \(^{19}F\) Daten in vivo, zu beseitigen.
Verstreut über den ganzen Text der Göttlichen Komödie kommen verschiedene geographische Namen vor, die sich auf Spanien beziehen. In mehreren dieser Fälle hat Dante die im wörtlichen Schriftsinn verwendeten toponymischen Zeichen als Elemente hermetisch wirkender Aussagen und damit offenbar als Indizien einer verborgenen Botschaft konzipiert. Zum Nachweis dieser These soll in den folgenden Betrachtungen erkundet werden, welche Funktion den im wissenschaftlichen Weltbild des Dichters verankerten spanischen Land- und Städtenamen in der Komposition des Epos zukommt. Damit möchte ich meinem Kollegen und Freund Gerhard Penzkofer für die vielen anregenden Gespräche danken, die wir – in den Jahren der gemeinsamen Tätigkeit in der Würzburger Romanistik – vor allem über cosas de España führen konnten. Da der vorliegende Band unter den von seiner Lehre inspirierten Leitbegriffen Kommunikation und Repräsentation steht, bietet es sich am Schluss an, die beiden Konzepte mit den vom Dichter diskutierten Termini sensus litteralis und sensus allegoricus in Beziehung zu setzen.
Background
Solitary metastases to the pancreas are rare. Therefore the value of resection in curative intention remains unclear. In the literature there are several promising reports about resection of solitary metastasis to the pancreas mainly of renal origin.
Case presentation
Here we report for the first time on the surgical therapy of a 1.5 cm solitary pancreatic metastasis of an adrenocortical carcinoma. The metastasis occurred almost 6 years after resection of the primary tumor. A partial pancreatoduodenectomy was performed and postoperatively adjuvant mitotane treatment was initiated. During the follow-up of 3 years after surgery no evidence of tumor recurrence occurred.
Conclusion
Resection of pancreatic tumors should be considered, even if the mass is suspicious for metastatic disease including recurrence of adrenocortical cancer.
Biomedical research suffers from a dramatically poor translational success. For example, in ischemic stroke, a condition with a high medical need, over a thousand experimental drug targets were unsuccessful. Here, we adopt methods from clinical research for a late-stage pre-clinical meta-analysis (MA) and randomized confirmatory trial (pRCT) approach. A profound body of literature suggests NOX\(_{2}\) to be a major therapeutic target in stroke. Systematic review and MA of all available NOX\(_{2}\)\(^{-/y}\) studies revealed a positive publication bias and lack of statistical power to detect a relevant reduction in infarct size. A fully powered multi-center pRCT rejects NOX\(_{2}\) as a target to improve neurofunctional outcomes or achieve a translationally relevant infarct size reduction. Thus stringent statistical thresholds, reporting negative data and a MA-pRCT approach can ensure biomedical data validity and overcome risks of bias.
Pulsars (in short for Pulsating Stars) are magnetized, fast rotating neutron stars. The basic picture of a pulsar describes it as a neutron star which has a rotation axis that is not aligned with its magnetic field axis. The emission is assumed to be generated near the magnetic poles of the neutron star and emitted along the open magnetic field lines. Consequently, the corresponding beam of photons is emitted along the magnetic field line axis. The non-alignment of both, the rotation and the magnetic field axis, results in the effect that the emission of the pulsar is only seen if its beam points towards the observer.
The emission from a pulsar is therefore perceived as being pulsed although its generation is not. This rather simple geometrical model is commonly referred to as Lighthouse Model and has been widely accepted. However, it does not deliver an explanation of the precise mechanisms behind the emission from pulsars (see below for more details).
Nowadays more than 2000 pulsars are known. They are observed at various wavelengths. Multiwavelength studies have shown that some pulsars are visible only at certain wavelengths while the emission from others can be observed throughout large parts of the electromagnetic spectrum. An example of the latter case is the Crab pulsar which is also the main object of interest in this thesis. Originating from a supernova explosion observed in 1054 A.D. and discovered in 1968, the Crab pulsar has been the central subject of numerous studies. Its pulsed emission is visible throughout the whole electromagnetic spectrum which makes it a key figure in understanding the possible mechanisms of multiwavelength emission from pulsars.
The Crab pulsar is also well known for its radio emission strongly varying on long as well as on short time scales. While long time scale behaviour from a pulsar is usually examined through the use of its average profile (a profile resulting from averaging of a large number of individual pulses resulting from single rotations), short time scale behaviour is examined via its single pulses. The short time scale anomalous behaviour of its radio emission is commonly referred to as Giant Pulses and represents the central topic of this thesis.
While current theoretical approaches place the origin of the radio emission from a pulsar like the Crab near its magnetic poles (Polar Cap Model) as already indicated by the Lighthouse model, its emission at higher frequencies, especially its gamma-ray emission, is assumed to originate further away in the geometrical region surrounding a pulsar which is commonly referred to as a pulsar magnetosphere (Outer Gap Model). Consequently, the respective emission regions are usually assumed not to be connected. However, past observational results from the Crab pulsar represent a contradiction to this assumption.
Radio giant pulses from the Crab pulsar have been observed to emit large amounts of energy on very short time scales implying small emission regions on the surface of the pulsar. Such energetic events might also leave a trace in the gamma-ray emission of the Crab pulsar.
The aim of this thesis is to search for this connection in the form of a correlation study between radio giant pulses and gamma-photons from the Crab pulsar.
To make such a study possible, a multiwavelength observational campaign was organized for which radio observations were independently applied for, coordinated and carried out with the Effelsberg radio telescope and the Westerbork Synthesis Radio Telescope and gamma-ray observations with the Major Atmospheric Imaging Cherenkov telescopes. The corresponding radio and gamma-ray data sets were reduced and the correlation analysis thereafter consisted of three different approaches:
1) The search for a clustering in the differences of the times of arrival of radio giant pulses and gamma-photons;
2) The search for a linear correlation between radio giant pulses and gamma-photons using the Pearson correlation approach;
3) A search for an increase of the gamma-ray flux around occurring radio giant pulses.
In the last part of the correlation study an increase of the number of gamma-photons centered on a radio giant pulse by about 17% (in contrast with the number of gamma-photons when no radio giant pulse occurs in the same time window) was discovered. This finding suggests that a new theoretical approach for the emission of young pulsars like the Crab pulsar, is necessary.
Background:
Grebe dysplasia, Hunter-Thompson dysplasia, and du Pan dysplasia constitute a spectrum of skeletal dysplasias inherited as an autosomal recessive trait characterized by short stature, severe acromesomelic shortening of the limbs, and normal axial skeleton. The majority of patients with these disorders have biallelic loss-of-function mutations of GDF5. In single instances, Grebe dysplasia and a Grebe dysplasia-like phenotype with genital anomalies have been shown to be caused by mutations in BMPR1B, encoding a GDF5 receptor.
Methods:
We clinically and radiologically characterised an acromesomelic chondrodysplasia in an adult woman born to consanguineous parents. We sequenced GDF5 and BMPR1B on DNA of the proposita. We performed 3D structural analysis and luciferase reporter assays to functionally investigate the identified BMPR1B mutation.
Results:
We extend the genotype-phenotype correlation in the acromesomelic chondrodysplasias by showing that the milder du Pan dysplasia can be caused by a hypomorphic BMPR1B mutation. We show that the homozygous c.91C>T, p.(Arg31Cys) mutation causing du Pan dysplasia leads to a significant loss of BMPR1B function, but to a lesser extent than the previously reported p.Cys53Arg mutation that results in the more severe Grebe dysplasia.
Conclusions:
The phenotypic severity gradient of the clinically and radiologically related acromesomelic chondrodysplasia spectrum of skeletal disorders may be due to the extent of functional impairment of the ligand-receptor pair GDF5-BMPR1B.
The stress hormone abscisic acid (ABA) induces expression of defence genes in many organs, modulates ion homeostasis and metabolism in guard cells, and inhibits germination and seedling growth. Concerning the latter effect, several mutants of Arabidopsis thaliana with improved capability for \(H^+\) efflux (wat1-1D, overexpression of AKT1 and ost2-1D) are less sensitive to inhibition by ABA than the wild type. This suggested that ABA could inhibit \(H^+\) efflux (\(H^+\)-ATPase) and induce cytosolic acidification as a mechanism of growth inhibition. Measurements to test this hypothesis could not be done in germinating seeds and we used roots as the most convenient system. ABA inhibited the root plasma-membrane H+-ATPase measured in vitro (ATP hydrolysis by isolated vesicles) and in vivo (\(H^+\) efflux from seedling roots). This inhibition involved the core ABA signalling elements: PYR/PYL/RCAR ABA receptors, ABA-inhibited protein phosphatases (HAB1), and ABA-activated protein kinases (SnRK2.2 and SnRK2.3). Electrophysiological measurements in root epidermal cells indicated that ABA, acting through the PYR/PYL/RCAR receptors, induced membrane hyperpolarization (due to \(K^+\) efflux through the GORK channel) and cytosolic acidification. This acidification was not observed in the wat1-1D mutant. The mechanism of inhibition of the \(H^+\)-ATPase by ABA and its effects on cytosolic pH and membrane potential in roots were different from those in guard cells. ABA did not affect the in vivo phosphorylation level of the known activating site (penultimate threonine) of (\(H^+\)-ATPase in roots, and SnRK2.2 phosphorylated in vitro the C-terminal regulatory domain of (\(H^+\)-ATPase while the guard-cell kinase SnRK2.6/OST1 did not.
In this thesis, I present a model system for carbohydrate interactions with single-crystalline Ru surfaces. Geometric and electronic properties of copper phthalocyanine (CuPc) on top of graphene on hexagonal Ru(0001), rectangular Ru(10-10) and vicinal Ru(1,1,-2,10) surfaces have been studied. First, the Fermi surfaces and band structures of the three Ru surfaces were investigated by high-resolution angle-resolved photoemission spectroscopy. The experimental data and theoretical calculations allow to derive detailed information about the momentum-resolved electronic structure. The results can be used as a reference to understand the chemical and catalytic properties of Ru surfaces. Second, graphene layers were prepared on the three different Ru surfaces. Using low-energy electron diffraction and scanning tunneling microscopy, it was found that graphene can be grown in well-ordered structures on all three surfaces, hexagonal Ru(0001), rectangular Ru(10-10) and vicinal Ru(1,1,-2,10), although they have different surface symmetries. Evidence for a strong interaction between graphene and Ru surfaces is a 1.3-1.7e V increase in the graphene pi-bands binding energy with respect to free-standing graphene sheets. This energy variation is due to the hybridization between the graphene pi bands and the Ru 4d electrons, while the lattice mismatch does not play an important role in the bonding between graphene and Ru surfaces. Finally, the geometric and electronic structures of CuPc on Ru(10-10), graphene/Ru(10-10), and graphene/Ru(0001) have been studied in detail. CuPc molecules can be grown well-ordered on Ru(10-10) but not on Ru(0001). The growth of CuPc on graphene/Ru(10-10) and Ru(0001) is dominated by the Moire pattern of graphene. CuPc molecules form well-ordered structures with rectangular unit cells on graphene/Ru(10-10) and Ru(0001). The distance of adjacent CuPc molecules is 1.5 and 1.3 nm on graphene/Ru(0001) and 1.54 and 1.37 nm on graphene/Ru(10-10). This indicates that the molecule-substrate interaction dominates over the intermolecular interaction for CuPc molecules on graphene/Ru(10-10) and graphene/Ru(0001).
Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose of this multi-laboratory study was to establish the precision and accuracy of basic data dimensions in AUC and validate previously proposed calibration techniques. Three kits of AUC cell assemblies containing radial and temperature calibration tools and a bovine serum albumin (BSA) reference sample were shared among 67 laboratories, generating 129 comprehensive data sets. These allowed for an assessment of many parameters of instrument performance, including accuracy of the reported scan time after the start of centrifugation, the accuracy of the temperature calibration, and the accuracy of the radial magnification. The range of sedimentation coefficients obtained for BSA monomer in different instruments and using different optical systems was from 3.655 S to 4.949 S, with a mean and standard deviation of (4.304\(\pm\)0.188) S (4.4%). After the combined application of correction factors derived from the external calibration references for elapsed time, scan velocity, temperature, and radial magnification, the range of s-values was reduced 7-fold with a mean of 4.325 S and a 6-fold reduced standard deviation of \(\pm\)0.030 S (0.7%). In addition, the large data set provided an opportunity to determine the instrument-to-instrument variation of the absolute radial positions reported in the scan files, the precision of photometric or refractometric signal magnitudes, and the precision of the calculated apparent molar mass of BSA monomer and the fraction of BSA dimers. These results highlight the necessity and effectiveness of independent calibration of basic AUC data dimensions for reliable quantitative studies.
Xenopus laevis (XLA) is an allotetraploid species which appears to have undergone whole-genome duplication after the interspecific hybridization of 2 diploid species closely related to Silurana/Xenopus tropicalis (XTR). Previous cDNA fluorescence in situ hybridization (FISH) experiments have identified 9 sets of homoeologous chromosomes in X. laevis, in which 8 sets correspond to chromosomes 1-8 of X. tropicalis (XTR1-XTR8), and the last set corresponds to a fusion of XTR9 and XTR10. In addition, recent X. laevis genome sequencing and BAC-FISH experiments support this physiological relationship and show no gross chromosome translocation in the X. laevis karyotype. Therefore, for the benefit of both comparative cytogenetics and genome research, we here propose a new chromosome nomenclature for X. laevis based on the phylogenetic relationship and chromosome length, i.e. XLA1L, XLA1S, XLA2L, XLA2S, and so on, in which the numbering of XLA chromosomes corresponds to that in X. tropicalis and the postfixes ‘L' and ‘S' stand for ‘long' and ‘short' chromosomes in the homoeologous pairs, which can be distinguished cytologically by their relative size. The last chromosome set is named XLA9L and XLA9S, in which XLA9 corresponds to both XTR9 and XTR10, and hence, to emphasize the phylogenetic relationship to X. tropicalis, XLA9_10L and XLA9_10S are also used as synonyms.
Taeniid cestodes (including the human parasites Echinococcus spp. and Taenia solium) have very few mobile genetic elements (MGEs) in their genome, despite lacking a canonical PIWI pathway. The MGEs of these parasites are virtually unexplored, and nothing is known about their expression and silencing. In this work, we report the discovery of a novel family of small nonautonomous long terminal repeat retrotransposons (also known as terminal-repeat retrotransposons in miniature, TRIMs) which we have named ta-TRIM (taeniid TRIM). ta-TRIMs are only the second family of TRIM elements discovered in animals, and are likely the result of convergent reductive evolution in different taxonomic groups. These elements originated at the base of the taeniid tree and have expanded during taeniid diversification, including after the divergence of closely related species such as Echinococcus multilocularis and Echinococcus granulosus. They are massively expressed in larval stages, from a small proportion of full-length copies and from isolated terminal repeats that show transcriptional read-through into downstream regions, generating novel noncoding RNAs and transcriptional fusions to coding genes. In E. multilocularis, ta-TRIMs are specifically expressed in the germinative cells (the somatic stem cells) during asexual reproduction of metacestode larvae. This would provide a developmental mechanism for insertion of ta-TRIMs into cells that will eventually generate the adult germ line. Future studies of active and inactive ta-TRIM elements could give the first clues on MGE silencing mechanisms in cestodes.
The possibility of investigating macroscopic coherent quantum states in polariton condensates and of engineering polariton landscapes in semiconductors has triggered interest in using polaritonic systems to simulate complex many-body phenomena. However, advanced experiments require superior trapping techniques that allow for the engineering of periodic and arbitrary potentials with strong on-site localization, clean condensate formation, and nearest-neighbor coupling. Here we establish a technology that meets these demands and enables strong, potentially tunable trapping without affecting the favorable polariton characteristics. The traps are based on a locally elongated microcavity which can be formed by standard lithography. We observe polariton condensation with non-resonant pumping in single traps and photonic crystal square lattice arrays. In the latter structures, we observe pronounced energy bands, complete band gaps, and spontaneous condensation at the M-point of the Brillouin zone.
Background
The prognostic value of histone γ-H2AX and 53BP1 proteins to predict the radiotherapy (RT) outcome of patients with rectal carcinoma (RC) was evaluated in a prospective study. High expression of the constitutive histone γ-H2AX is indicative of defective DNA repair pathway and/or genomic instability, whereas 53BP1 (p53-binding protein 1) is a conserved checkpoint protein with properties of a DNA double-strand breaks sensor.
Methods
Using fluorescence microscopy, we assessed spontaneous and radiation-induced foci of γ-H2AX and 53BP1 in peripheral blood mononuclear cells derived from unselected RC patients (n = 53) undergoing neoadjuvant chemo- and RT. Cells from apparently healthy donors (n = 12) served as references.
Results
The γ-H2AX assay of in vitro irradiated lymphocytes revealed significantly higher degree of DNA damage in the group of unselected RC patients with respect to the background, initial (0.5 Gy, 30 min) and residual (0.5 Gy and 2 Gy, 24 h post-radiation) damage compared to the control group. Likewise, the numbers of 53BP1 foci analyzed in the samples from 46 RC patients were significantly higher than in controls except for the background DNA damage. However, both markers were not able to predict tumor stage, gastrointestinal toxicity or tumor regression after curative RT. Interestingly, the mean baseline and induced DNA damage was found to be lower in the group of RC patients with tumor stage IV (n = 7) as compared with the stage III (n = 35). The difference, however, did not reach statistical significance, apparently, because of the limited number of patients.
Conclusions
The study shows higher expression of γ-H2AX and 53BP1 foci in rectal cancer patients compared with healthy individuals. Yet the data in vitro were not predictive in regard to the radiotherapy outcome.
A simple test setup has been developed at Institute of Aerospace Information Technology, University of Würzburg, Germany to realize basic functionalities for formation flight of quadrocopters. The test environment is planned to be utilized for developing and validating the algorithms for formation flying capability in real environment as well as for education purpose. An already existing test bed for single quadrocopter was extended with necessary inter-communication and distributed control mechanism to test the algorithms for formation flights in 2 degrees of freedom (roll / pitch). This study encompasses the domain of communication, control engineering and embedded systems programming. Bluetooth protocol has been used for inter-communication between two quadrocopters. A simple approach of PID control in combination with Kalman filter has been exploited. MATLAB Instrument Control Toolbox has been used for data display, plotting and analysis. Plots can be drawn in real-time and received information can also be stored in the form of files for later use and analysis. The test setup has been developed indigenously and at considerably low cost. Emphasis has been placed on simplicity to facilitate students learning process. Several lessons have been learnt during the course of development of this setup. Proposed setup is quite flexible that can be modified as per changing requirements.
The learned helplessness phenomenon is a specific animal behavior induced by prior exposure to uncontrollable aversive stimuli. It was first found by Seligman and Maier (1967) in dogs and then has been reported in many other species, e.g. in rats (Vollmayr and Henn, 2001), in goldfishes (Padilla, 1970), in cockroaches (Brown, 1988) and also in fruit flies (Brown, 1996; Bertolucci, 2008). However, the learned helplessness effect in fruit flies (Drosophila melanogaster) has not been studied in detail. Thus, in this doctoral study, we investigated systematically learned helplessness behavior of Drosophila for the first time.
Three groups of flies were tested in heatbox. Control group was in the chambers experiencing constant, mild temperature. Second group, master flies were punished in their chambers by being heated if they stopped walking for 0.9s. The heat pulses ended as soon as they resumed walking again. A third group, the yoked fly, was in their chambers at the same time. However, their behavior didn’t affect anything: yoked flies were heated whenever master flies did, with same timing and durations. After certain amount of heating events, yoked flies associated their own behavior with the uncontrollability of the environment. They suppressed their innate responses such as reducing their walking time and walking speed; making longer escape latencies and less turning around behavior under heat pulses. Even after the conditioning phase, yoked flies showed lower activity level than master and control flies. Interestingly, we have also observed sex dimorphisms in flies. Male flies expressed learned helplessness not like female flies. Differences between master and yoked flies were smaller in male than in female flies. Another interesting finding was that prolonged or even repetition of training phases didn’t enhance learned helplessness effect in flies.
Furthermore, we investigated serotonergic and dopaminergic nervous systems in learned helplessness. Using genetic and pharmacological manipulations, we altered the levels of serotonin and dopamine in flies’ central nervous system. Female flies with reduced serotonin concentration didn’t show helpless behavior, while the learned helplessness effect in male flies seems not to be affected by a reduction of serotonin. Flies with lower dopamine level do not display the learned helplessness effect in the test phase, suggesting that with low dopamine the motivational change in learned helplessness in Drosophila may decline faster than with a normal dopamine level.
Sex-specific markers are a prerequisite for understanding reproductive biology, genetic factors involved in sex differences, mechanisms of sex determination, and ultimately the evolution of sex chromosomes. The Western mosquitofish, Gambusia affinis, may be considered a model species for sex-chromosome evolution, as it displays female heterogamety (ZW/ZZ), and is also ecologically interesting as a worldwide invasive species. Here, de novo RNA-sequencing on the gonads of sexually mature G. affinis was used to identify contigs that were highly transcribed in females but not in males (i.e., transcripts with ovary-specific expression). Subsequently, 129 primer pairs spanning 79 contigs were tested by PCR to identify sex-specific transcripts. Of those primer pairs, one female-specific DNA marker was identified, Sanger sequenced and subsequently validated in 115 fish. Sequence analyses revealed a high similarity between the identified sex-specific marker and the 3' UTR of the aminomethyl transferase (amt) gene of the closely related platyfish (Xiphophorus maculatus). This is the first time that RNA-seq has been used to successfully characterize a sex-specific marker in a fish species in the absence of a genome map. Additionally, the identified sex-specific marker represents one of only a handful of such markers in fishes.
Background
During development in human erythrocytes, Plasmodium falciparum parasites display a remarkable number of adhesive proteins on their plasma membrane. In the invasive merozoites, these include members of the PfMSP1 and PfAMA1/RON complexes, which facilitate contact between merozoites and red blood cells. In gametocytes, sexual precursor cells mediating parasite transmission to the mosquito vector, plasma membrane-associated proteins primarily belong to the PfCCp and 6-cys families with roles in fertilization. This study describes a newly identified WD40-repeat protein unique to Plasmodium species that associates with adhesion protein complexes of both merozoites and gametocytes.
Methods
The WD40-repeat protein-like protein PfWLP1 was identified via co-immunoprecipitation assays followed by mass spectrometry and characterized using biochemical and immunohistochemistry methods. Reverse genetics were employed for functional analysis.
Results
PfWLP1 is expressed both in schizonts and gametocytes. In mature schizonts, the protein localizes underneath the merozoite micronemes and interacts with PfAMA1, while in gametocytes PfWLP1 primarily accumulates underneath the plasma membrane and associates with PfCCp1 and Pfs230. Reverse genetics failed to disrupt the pfwlp1 gene, while haemagglutinin-tagging was feasible, suggesting a crucial function for PfWLP1 during blood stage replication.
Conclusions
This is the first report on a plasmodial WD40-repeat protein associating with cell adhesion proteins. Since WD40 domains are known to mediate protein–protein contact by serving as a rigid scaffold for protein interactions, the presented data suggest that PfWLP1 supports the stability of adhesion protein complexes of the plasmodial blood stages.
Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells (DIRCs) capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1 (PD-1). Purified Abcb5\(^+\) DIRCs suppressed T cell proliferation, evaded immune rejection, homed to recipient immune tissues, and induced Tregs in vivo. In fully major-histocompatibility-complex-mismatched cardiac allotransplantation models, allogeneic DIRCs significantly prolonged allograft survival. Blockade of DIRC-expressed PD-1 reversed the inhibitory effects of DIRCs on T cell activation, inhibited DIRC-dependent Treg induction, and attenuated DIRC-induced prolongation of cardiac allograft survival, indicating that DIRC immunoregulatory function is mediated, at least in part, through PD-1. Our results identify ABCB5\(^+\) DIRCs as a distinct immunoregulatory cell population and suggest promising roles of this expandable cell subset in cellular immunotherapy.
The International Symposium on Phytochemicals in Medicine and Food (ISPMF2015), organized by the Phytochemical Society of Europe (PSE) and the Phytochemical Society of Asia (PSA), was held June 26-29, 2015, in Shanghai of China. This was the first time that a PSE meeting has been held in Asia and a PSE-PSA joint symposium provided an opportunity for communication between scientists from Europe and Asia and other continents. ISPMF2015 has been jointly sponsored by Fujian Agriculture and Forestry University, Guizhou Medical University, Shanghai Normal University, Yancheng Institute of Technology, Beijing Normal University, and Fudan University. More than 270 scientists from 48 countries attended this meeting and presented their research and opinions on phytochemistry, phytomedicine and phytoneering. The international organizing committee and scientific advisory board of ISPMF 2015 comprised of outstanding scientists from around the globe. Dr. Jianbo Xiao was the chairman of the International Organizing Committee of ISPMF2015 and moderated the open address on June 26.
The organizing committee of ISPMF2015 assembled an exciting and diverse program, featuring 16 sessions including 12 plenary lectures, 20 invited talks, 55 short oral presentations, and more than 130 posters, which were dedicated to creating a podium for exchanging the latest research results in the phytochemicals for food and human health.
Accessing topological superconductivity via a combined STM and renormalization group analysis
(2015)
The search for topological superconductors has recently become a key issue in condensed matter physics, because of their possible relevance to provide a platform for Majorana bound states, non-Abelian statistics, and quantum computing. Here we propose a new scheme which links as directly as possible the experimental search to a material-based microscopic theory for topological superconductivity. For this, the analysis of scanning tunnelling microscopy, which typically uses a phenomenological ansatz for the superconductor gap functions, is elevated to a theory, where a multi-orbital functional renormalization group analysis allows for an unbiased microscopic determination of the material-dependent pairing potentials. The combined approach is highlighted for paradigmatic hexagonal systems, such as doped graphene and water-intercalated sodium cobaltates, where lattice symmetry and electronic correlations yield a propensity for a chiral singlet topological superconductor. We demonstrate that our microscopic material-oriented procedure is necessary to uniquely resolve a topological superconductor state.
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes
(2015)
Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). Up to 60% of affected males fulfill criteria for autism spectrum disorder (ASD), making FXS the most frequent monogenetic cause of syndromic ASD. It is unknown, however, whether normal variants (independent of mutations) in the fragile X gene family (FMR1, FXR1, FXR2) and in FMR2 modulate autistic features. Here, we report an accumulation model of 8 SNPs in these genes, associated with autistic traits in a discovery sample of male patients with schizophrenia (N = 692) and three independent replicate samples: patients with schizophrenia (N = 626), patients with other psychiatric diagnoses (N = 111) and a general population sample (N = 2005). For first mechanistic insight, we contrasted microRNA expression in peripheral blood mononuclear cells of selected extreme group subjects with high-versus low-risk constellation regarding the accumulation model. Thereby, the brain-expressed miR-181 species emerged as potential "umbrella regulator", with several seed matches across the fragile X gene family and FMR2. To conclude, normal variation in these genes contributes to the continuum of autistic phenotypes.
In dorsal root ganglia (DRG) neurons TRESK channels constitute a major current component of the standing outward current IK\(_{SO}\). A prominent physiological role of TRESK has been attributed to pain sensation. During inflammation mediators of pain e.g. lysophosphatidic acid (LPA) are released and modulate nociception. We demonstrate co-expression of TRESK and LPA receptors in DRG neurons. Heterologous expression of TRESK and LPA receptors in Xenopus oocytes revealed augmentation of basal K\(^{+}\) currents upon LPA application. In DRG neurons nociception can result from TRPV\(_{1}\) activation by capsaicin or LPA. Upon co-expression in Xenopus oocytes LPA simultaneously increased both depolarising TRPV\(_{1}\) and hyperpolarising TRESK currents. Patch-clamp recordings in cultured DRG neurons from TRESK[wt] mice displayed increased IK\(_{SO}\) after application of LPA whereas under these conditions IK\(_{SO}\) in neurons from TRESK[ko] mice remained unaltered. Under current-clamp conditions LPA application differentially modulated excitability in these genotypes upon depolarising pulses. Spike frequency was attenuated in TRESK[wt] neurons and, in contrast, augmented in TRESK[ko] neurons. Accordingly, excitation of nociceptive neurons by LPA is balanced by co-activation of TRESK channels. Hence excitation of sensory neurons is strongly controlled by the activity of TRESK channels, which therefore are good candidates for the treatment of pain disorders.
The role of serum amyloid A (SAA) proteins, which are ligands for toll-like receptors, was analyzed in human bone marrow-derived mesenchymal stem cells (hMSCs) and their osteogenic offspring with a focus on senescence, differentiation andmineralization. In vitro aged hMSC developed a senescence-associated secretory phenotype (SASP), resulting in enhanced SAA1/2, TLR2/4 and proinflammatory cytokine (IL6, IL8, IL1\(\beta\), CXCL1, CXCL2) expression before entering replicative senescence. Recombinant human SAA1 (rhSAA1) induced SASP-related genes and proteins in MSC, which could be abolished by cotreatment with the TLR4-inhibitor CLI-095. The same pattern of SASP-resembling genes was stimulated upon induction of osteogenic differentiation, which is accompanied by autocrine SAA1/2 expression. In this context additional rhSAA1 enhanced the SASP-like phenotype, accelerated the proinflammatory phase of osteogenic differentiation and enhanced mineralization. Autocrine/paracrine and rhSAA1 via TLR4 stimulate a proinflammatory phenotype that is both part of the early phase of osteogenic differentiation and the development of senescence. This signaling cascade is tightly involved in bone formation and mineralization, but may also propagate pathological extraosseous calcification conditions such as calcifying inflammation and atherosclerosis.
Additive manufacturing of scaffolds with sub-micron filaments via melt electrospinning writing
(2015)
The aim of this study was to explore the lower resolution limits of an electrohydrodynamic process combined with direct writing technology of polymer melts. Termed melt electrospinning writing, filaments are deposited layer-by-layer to produce discrete three-dimensional scaffolds for in vitro research. Through optimization of the parameters (flow rate, spinneret diameter, voltage, collector distance) for poly-ϵ-caprolactone, we could direct-write coherent scaffolds with ultrafine filaments, the smallest being 817 ± 165 nm. These low diameter filaments were deposited to form box-structures with a periodicity of 100.6 ± 5.1 μm and a height of 80 μm (50 stacked filaments; 100 overlap at intersections). We also observed oriented crystalline regions within such ultrafine filaments after annealing at 55 °C. The scaffolds were printed upon NCO-sP(EO-stat-PO)-coated glass slide surfaces and withstood frequent liquid exchanges with negligible scaffold detachment for at least 10 days in vitro.
Background:
Oral anticoagulant therapy (OAT) potently prevents strokes in patients with atrial fibrillation. Vitamin K antagonists (VKA) have been the standard of care for long-term OAT for decades, but non-VKA oral anticoagulants (NOAC) have recently been approved for this indication, and raised many questions, among them their influence on medication adherence. We assessed adherence to VKA and NOAC in secondary stroke prevention.
Methods:
All patients treated from October 2011 to September 2012 for ischemic stroke or transient ischemic attack with a subsequent indication for OAT, at three academic hospitals were entered into a prospective registry, and baseline data and antithrombotic treatment at discharge were recorded. At the 1-year follow-up, we assessed the adherence to different OAT strategies and patients' adherence to their respective OAT. We noted OAT changes, reasons to change treatment, and factors that influence persistence to the prescribed OAT.
Results:
In patients discharged on OAT, we achieved a fatality corrected response rate of 73.3% (n=209). A total of 92% of these patients received OAT at the 1-year follow-up. We observed good adherence to both VKA and NOAC (VKA, 80.9%; NOAC, 74.8%; P=0.243) with a statistically nonsignificant tendency toward a weaker adherence to dabigatran. Disability at 1-year follow-up was an independent predictor of lower adherence to any OAT after multivariate analysis, whereas the choice of OAT did not have a relevant influence.
Conclusion:
One-year adherence to OAT after stroke is strong (>90%) and patients who switch therapy most commonly switch toward another OAT. The 1-year adherence rates to VKA and NOAC in secondary stroke prevention do not differ significantly between both therapeutic strategies.
Several aspects of the stability analysis of large-scale discrete-time systems are considered. An important feature is that the right-hand side does not have have to be continuous.
In particular, constructive approaches to compute Lyapunov functions are derived and applied to several system classes.
For large-scale systems, which are considered as an interconnection of smaller subsystems, we derive a new class of small-gain results, which do not require the subsystems to be robust in some sense. Moreover, we do not only study sufficiency of the conditions, but rather state an assumption under which these conditions are also necessary.
Moreover, gain construction methods are derived for several types of aggregation, quantifying how large a prescribed set of interconnection gains can be in order that a small-gain condition holds.
In today’s social online world there is a variety of interaction and participatory possibilities which enable web users to actively produce content themselves.
This user-generated content is omnipresent in the web and there is growing evidence that it is used to select or evaluate professionally created online information.
The present study investigated how this surrounding content affects online advertising by drawing from social influence theory. Specifically, it was assumed that
web users sharing an interpersonal relationship (interpersonal influence) and/or a group membership (collective influence) with authors of user-generated content
which appears next to advertising on the web page are more strongly influenced in their response to the advertising than unrelated users. These assumptions were
tested in a 2 × 2 between-subject experiment with 118 students who were exposed to four different Facebook profiles that differed in terms of interpersonal
connection to the source (existent/non-existent) and collective connection to the source (existent/non-existent). The results show a significant impact in the case
of collective influence, but not in the case of interpersonal influence. The underlying mechanisms of this effect and implications of the results for online advertising
are discussed.
Die Möglichkeiten der operativen Rekonstruktion degenerativ veränderter Hüftgelenke sind komplex und vielfältig. Bei den derzeit zur Verfügung stehenden operativen Behandlungsmassnahmen führen die Vor- und Nachteile immer wieder zur Diskussionen und Abwägung der Operationsverfahren. Hierbei stehen sich die rasche postoperative Mobilisierung sowie eine verminderte Rekonvaleszenzzeit mit den diskutierten Nachteilen einer schlechteren Übersichtlichkeit und damit verbundenen Fehlimplantationen gegenüber. Dies und die damit verbundene volkswirtschaftliche Bedeutung sind ein ständiger Ausgangspunkt für das Bemühen den optimalen Zugangsweg zu etablieren. Daher stellte das von Smith-Peterson 1949 publizierte Verfahren einen Meilenstein in der operativen Therapie dar. Hierdurch konnten zum einen die operationstechnischen Vorteile wie auch das volkswirtschaftliche Begehren nach kürzeren postoperativen Verweildauern vereint werden. Die Modifizierung dieses Zugangsweges hat sich bereits in einer großen Anzahl prospektiver Studien als zuverlässiges Rekonstruktionsverfahren etabliert und erfüllt zudem auch die Anforderungen der heutigen Medizin nach ästhetisch schönen Ergebnissen. In der vorliegenden Arbeit wurde eine prospektive Fallstudie des direkten anterioren Zugangs mit einem gesunden Vergleichskollektiv durchgeführt. Mit dem Ziel, die Aktivität ein Jahr postoperativ nach Implantation einer HTEP mit gesunden Probanden zu vergleichen. Von Januar 2009 bis Mai 2011 wurden insgesamt 77 Patienten und 59 Probanden in die Studie aufgenommen. Als Vergleichswerte wurde zum einen die klinische wie auch die radiologische Untersuchung herangezogen. In der klinischen Untersuchung zeigte sich insgesamt ein signifikanter Anstieg der untersuchten Scores im Vergleich mit den präoperativen Ergebnissen bei den Operierten. Im Vergleich zu den Probanden erzielen die Patienten ein Jahr nach HTEP teilweise noch schlechtere Werte in dem Bewegungsumfang und den Aktivitätsniveaus welche mittels der Auswertung des Stepwatches, des TWB und des Arzt-Patienten-Fragebogens erhoben wurden. Die radiologische Bewertung diente zur Feststellung der Positionierung der HTEP. Mit guten Positionierungen durch den direkten anterioren Zugang. Die Bewertung der Funktionalität zwischen den beiden Gruppen erfolgte durch den HHS, XSFMA- D und den Arzt-Patientenfragenbogen. Hierbei konnten ähnliche Ergebnisse, wie bereits oben beschrieben, verzeichnet werden mit guten Werten in der Gruppe der untersuchten Patienten, jedoch einer geringeren Funktionalität im Vergleich zu den Probanden. Die vorliegende Arbeit zeigt, dass der direkte anteriore Zugang die Wiederherstellung eines guten postoperativen Gesundheitszustandes mit erreichen eines hohen postoperativen Aktivitätslevels der Patienten ermöglicht. Ebenso erfüllt dieser Zugangsweg die Anforderungen der heutigen Medizin im Sinne einer schnellen postoperativen Mobilisation. Im Vergleich zu anderen minimal-invasiven Verfahren zeigen sich eine gute Implantierbarkeit, eine gute Positionierung und ein niedriges Komplikationsniveau. Prinzipiell hat der minimal-invasive anteriore Zugang das Potenzial sich als ein Standardverfahren in der operativen Rekonstruktion bei Hüftgelenksersatz zu etablieren, jedoch wäre ein direkter Vergleich mit dem lateralen Zugang erstrebenswert und sollte in weiteren Studien verglichen werden.
Die Möglichkeiten der operativen Rekonstruktion degenerativ veränderter Hüftgelenke sind komplex und vielfältig. Bei den derzeit zur Verfügung stehenden operativen Behandlungsmassnahmen führen die Vor- und Nachteile immer wieder zur Diskussionen und Abwägung der Operationsverfahren. Hierbei stehen sich die rasche postoperative Mobilisierung sowie eine verminderte Rekonvaleszenzzeit mit den diskutierten Nachteilen einer schlechteren Übersichtlichkeit und damit verbundenen Fehlimplantationen gegenüber. Dies und die damit verbundene volkswirtschaftliche Bedeutung sind ein ständiger Ausgangspunkt für das Bemühen den optimalen Zugangsweg zu etablieren.
Daher stellte das von Smith-Peterson 1949 publizierte Verfahren einen Meilenstein in der operativen Therapie dar. Hierdurch konnten zum einen die operationstechnischen Vorteile wie auch das volkswirtschaftliche Begehren nach kürzeren postoperativen Verweildauern vereint werden. Die Modifizierung dieses Zugangsweges hat sich bereits in einer großen Anzahl prospektiver Studien als zuverlässiges Rekonstruktionsverfahren etabliert und erfüllt zudem auch die Anforderungen der heutigen Medizin nach ästhetisch schönen Ergebnissen.
In der vorliegenden Arbeit wurde eine prospektive Fallstudie des direkten anterioren Zugangs mit einem gesunden Vergleichskollektiv durchgeführt. Mit dem Ziel, die Aktivität ein Jahr postoperativ nach Implantation einer HTEP mit gesunden Probanden zu vergleichen.
Von Januar 2009 bis Mai 2011 wurden insgesamt 77 Patienten und 59 Probanden in die Studie aufgenommen. Als Vergleichswerte wurde zum einen die klinische wie auch die radiologische Untersuchung herangezogen. In der klinischen Untersuchung zeigte sich insgesamt ein signifikanter Anstieg der untersuchten Scores im Vergleich mit den präoperativen Ergebnissen bei den Operierten. Im Vergleich zu den Probanden erzielen die Patienten ein Jahr nach HTEP teilweise noch schlechtere Werte in dem Bewegungsumfang und den Aktivitätsniveaus welche mittels der Auswertung des Stepwatches, des TWB und des Arzt-Patienten-Fragebogens erhoben wurden. Die radiologische Bewertung diente zur Feststellung der Positionierung der HTEP. Mit guten Positionierungen durch den direkten anterioren Zugang. Die Bewertung der Funktionalität zwischen den beiden Gruppen erfolgte durch den HHS, XSFMA- D und den Arzt-Patientenfragenbogen. Hierbei konnten ähnliche Ergebnisse, wie bereits oben beschrieben, verzeichnet werden mit guten Werten in der Gruppe der untersuchten Patienten, jedoch einer geringeren Funktionalität im Vergleich zu den Probanden.
Die vorliegende Arbeit zeigt, dass der direkte anteriore Zugang die Wiederherstellung eines guten postoperativen Gesundheitszustandes mit erreichen eines hohen postoperativen Aktivitätslevels der Patienten ermöglicht. Ebenso erfüllt dieser Zugangsweg die Anforderungen der heutigen Medizin im Sinne einer schnellen postoperativen Mobilisation. Im Vergleich zu anderen minimal-invasiven Verfahren zeigen sich eine gute Implantierbarkeit, eine gute Positionierung und ein niedriges Komplikationsniveau.
Prinzipiell hat der minimal-invasive anteriore Zugang das Potenzial sich als ein Standardverfahren in der operativen Rekonstruktion bei Hüftgelenksersatz zu etablieren, jedoch wäre ein direkter Vergleich mit dem lateralen Zugang erstrebenswert und sollte in weiteren Studien verglichen werden.
Fragestellung
Die Prognose eines akuten Hirninfarktes bei Verschluss einer proximalen Hirnarterie ist trotz der intravenösen Thrombolyse mit rtPA ungünstig. Kann die kombinierte pharmaco-mechanische Rekanalisation von proximalen Gefäßverschlüssen bei akutem Hirninfarkt zu einer Verbesserung des klinischen Ergebnisses führen?
Methoden
Wir analysierten retrospektiv 66 konsekutiv aufgenommene Patienten (36m, 30w; mittleres Alter 61 Jahre (23-86 Jahre), die von 2010 bis 2012 kombiniert pharmako-mechanisch intra-arteriell behandelt wurden. 32 Patienten wiesen einen kombinierten ACI-/M1-Verschluss, 23 einen M1-Verschluss und 11 eine Basilaristhrombose auf. Mittlerer NIHSS lag bei 23. 57 Patienten erhielten eine kombinierte pharmaco-mechanische Therapie, 3 Patienten wurden lediglich pharmakologisch und 6 Patienten rein mechanisch rekanalisiert. Rekanalisierung bei 35 Patienten mit einem Stent-Retriever (32 Patienten mit pREset, 3 Patienten mit SOLITAIRE) erfolgt. Bei 46 Patienten wurde rtPA und bei 32 Patienten Tirofiban als Bridging Verfahren eingesetzt. Eine Stentanlage erfolgte in 28,78% der Fälle.
Ergebnisse
Die erzielten Rekanalisationsraten lagen bei 89,4% bei einer mittleren Dauer der Intervention von 96 Minuten (53,03% unter 90 Min.). Ein günstiges klinisches Ergebnis nach mRS (mRS 0-2) wurde bei 48% der Patienten erreicht. Die Rate an symptomatischen intrazerebralen Blutungen lag bei 4,55%. Die Mortalität war 19,7%. Die multivariate Regressionsanalyse ergab als modifizierbare Prediktoren für ein günstiges Outcome die Dauer bis zur Rekanalisation und die Gabe von rtPA.
Schlussfolgerungen
Die kombinierte endovaskuläre pharmako-mechanische Therapie kann die Mortalität und Morbidität von Schlaganfallpatienten mit Verschlüssen einer proximalen Hirnarterie reduzieren.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease of the brain, which is characterized by a progressive loss of memory and spatial orientation. Only less than 5-10% of AD sufferers are familial cases due to genetic mutations in the amyloid precursor protein (APP) gene or presenilin (PS) 1 and 2 genes. The cause of sporadic AD (sAD) which covers > 95% of AD patients is still unknown. Current research found interactions between aging, diabetes and cognitive decline including dementia in general and in AD in particular. Disturbances of brain glucose uptake, glucose tolerance and utilization and impairment of the insulin/insulin receptor (IR) signaling cascade are thought to be key targets for the development of sAD.
In the brain of AD patients, neural plasticity is impaired indicated by synaptic and neuronal loss. Adult neurogenesis (AN), the generation of functional neurons in the adult brain, may be able to restore neurological function deficits through the integration of newborn neurons into existing neural networks. The dentate gyrus of the hippocampus is one out of few brain regions where life-long AN exists. However, there is a big controversy in literature regarding the involvement of AN in AD pathology. Most animal studies used transgenic mice based on the Amyloid ß (Aß) hypothesis which primarily act as models for the familial form of AD. Findings from human post mortem AN studies were also inconstistent. In this thesis, we focused on the possible involvement of AN in the pathogenesis of the sporadic form of AD. Streptozotocin intracerebroventricularily (STZ icv) treated rats, which develop an insulin-resistant brain state and learning and memory deficits preceding Aß pathology act as an appropriate animal model for sAD. We used STZ treatment for both parts of my work, for the in vivo and in vitro study.
In the first part of my thesis, my coworkers and I investigated STZ icv treatment effects on different stages of AN in an in vivo approach. Even if STZ icv treatment does not seem to considerably influence stem cell proliferation over a short-term (1 month after STZ icv treatment) as well as in a long-term (3 months after STZ icv treatment) period, it results in significantly less immature and newborn mature neurons 3 months after STZ icv treatment. This reduction detected after 3 months was specific for the septal hippocampus, discussed to be important for spatial learning. Subsequently we performed co-localization studies with antibodies detecting BrdU (applied appr. 27 days before sacrifice) and cell-type specific markers such as NeuN, and GFAP, we found that STZ treatment does not affect the differentiation fate of newly generated cells. Phenotype analysis of BrdU-positive cells in the hilus and molecular layer revealed that some of the BrdU-positive cells are newborn oligodendrocytes but not newborn microglia.
In the second part of my thesis I worked with cultured neural stem cells (NSCs) isolated from the adult rat hippocampus to reveal STZ effects on the proliferation of of NSCs, and on the survival and differentiation of their progeny. Furthermore, this in vitro approach enabled me to study cellular mechanisms underlying the observed impaired neurogenesis in the hippocampus of STZ-treated rats. In contrast to our findings of the STZ icv in vivo study we revealed that STZ supplied with the cell culture medium inhibits the proliferation of NSCs in a dose-dependent and time-dependent manner. Moreover, performing immunofluorescence studies with antibodies detecting cell-type specific markers after triggering NSCs to differentiate, we could show that STZ treatment affects the number of newly generated neurons but not of astrocytes. Analyzing newborn cells starting to differentiate and migrate I was able to demonstrate that STZ has no effect on the migration of newborn cells. Trying to reveal cellular mechanisms underlying the negative influence of STZ on hippocampal AN, we performed qRT-PCR and immunofluorescence staining and thus could show that in NSCs the expression of glucose transporter (GLUT)3 mRNA as well as IR and GLUT3 protein levels are reduced after STZ treatment. Therefore, the inhibition of the proliferation of NSCs may be (at least partially) caused by these two molecules. Interestingly, the effect of STZ on differentiating cells was shown to be different, as IR protein expression was not significantly changed but GLUT3 protein levels were decreased in consequence of STZ treatment.
In summary, this project delivered further insights into the interrelation between AN the sporadic form of sAD and thus provides a basis of new therapeutic approaches in sAD treatment through intervening AN. Discrepancies between the results of the two parts of my thesis, the in vivo and in vitro part, were certainly caused to a certain extent by the missing microenvironment in the in vitro approach with cultured NSCs. Future studies e.g. using co-culture systems could at least minimize the effect of a missing natural microenvironment of cultured NSCs, so that the use of an in vitro approach for the investigation of STZ treatment underlying cellular mechanisms can be improved.
To investigate the usefulness of pain-related evoked potentials (PREP) elicited by electrical stimulation for the identification of small fiber involvement in patients with mixed fiber neuropathy (MFN). Eleven MFN patients with clinical signs of large fiber impairment and neuropathic pain and ten healthy controls underwent clinical and electrophysiological evaluation. Small fiber function, electrical conductivity and morphology were examined by quantitative sensory testing (QST), PREP, and skin punch biopsy. MFN was diagnosed following clinical and electrophysiological examination (chronic inflammatory demyelinating neuropathy: n = 6; vasculitic neuropathy: n = 3; chronic axonal neuropathy: n = 2). The majority of patients with MFN characterized their pain by descriptors that mainly represent C-fiber-mediated pain. In QST, patients displayed elevated cold, warm, mechanical, and vibration detection thresholds and cold pain thresholds indicative of MFN. PREP amplitudes in patients correlated with cold (p < 0.05) and warm detection thresholds (p < 0.05). Burning pain and the presence of par-/dysesthesias correlated negatively with PREP amplitudes (p < 0.05). PREP amplitudes correlating with cold and warm detection thresholds, burning pain, and par-/dysesthesias support employing PREP amplitudes as an additional tool in conjunction with QST for detecting small fiber impairment in patients with MFN.
Background
To use combinatorial epitope mapping ("fingerprinting") of the antibody response to identify targets of the humoral immune response in patients with transitional cell carcinoma (TCC) of the bladder.
Methods
A combinatorial random peptide library was screened on the circulating pool of immunoglobulins purified from an index patient with a high risk TCC (pTa high grade plus carcinoma in situ) to identify corresponding target antigens. A patient cohort was investigated for antibody titers against ubiquitin.
Results
We selected, isolated, and validated an immunogenic peptide motif from ubiquitin as a dominant epitope of the humoral response. Patients with TCC had significantly higher antibody titers against ubiquitin than healthy donors (p<0.007), prostate cancer patients (p<0.0007), and all patients without TCC taken together (p<0.0001). Titers from superficial tumors were not significantly different from muscle invasive tumors (p = 0.0929). For antibody response against ubiquitin, sensitivity for detection of TCC was 0.44, specificity 0.96, positive predictive value 0.96 and negative predictive value 0.41. No significant titer changes were observed during the standard BCG induction immunotherapy.
Conclusions
This is the first report to demonstrate an anti-ubiquitin antibody response in patients with TCC. Although sensitivity of antibody production was low, a high specificity and positive predictive value make ubiquitin an interesting candidate for further diagnostic and possibly immune modulating studies.
Brain-computer interfaces (BCIs) can serve as muscle independent communication aids. Persons, who are unable to control their eye muscles (e.g., in the completely locked-in state) or have severe visual impairments for other reasons, need BCI systems that do not rely on the visual modality. For this reason, BCIs that employ auditory stimuli were suggested. In this study, a multiclass BCI spelling system was implemented that uses animal voices with directional cues to code rows and columns of a letter matrix. To reveal possible training effects with the system, 11 healthy participants performed spelling tasks on 2 consecutive days. In a second step, the system was tested by a participant with amyotrophic lateral sclerosis (ALS) in two sessions. In the first session, healthy participants spelled with an average accuracy of 76% (3.29 bits/min) that increased to 90% (4.23 bits/min) on the second day. Spelling accuracy by the participant with ALS was 20% in the first and 47% in the second session. The results indicate a strong training effect for both the healthy participants and the participant with ALS. While healthy participants reached high accuracies in the first session and second session, accuracies for the participant with ALS were not sufficient for satisfactory communication in both sessions. More training sessions might be needed to improve spelling accuracies. The study demonstrated the feasibility of the auditory BCI with healthy users and stresses the importance of training with auditory multiclass BCIs, especially for potential end-users of BCI with disease.
Introduction:
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers.
Methods:
We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals.
Results:
We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk.
Conclusions:
This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.
An Overview of the Regional Experiments for Land-atmosphere Exchanges 2012 (REFLEX 2012) Campaign
(2015)
The REFLEX 2012 campaign was initiated as part of a training course on the organization of an airborne campaign to support advancement of the understanding of land-atmosphere interaction processes. This article describes the campaign, its objectives and observations, remote as well as in situ. The observations took place at the experimental Las Tiesas farm in an agricultural area in the south of Spain. During the period of ten days, measurements were made to capture the main processes controlling the local and regional land-atmosphere exchanges. Apart from multi-temporal, multi-directional and multi-spatial space-borne and airborne observations, measurements of the local meteorology, energy fluxes, soil temperature profiles, soil moisture profiles, surface temperature, canopy structure as well as leaf-level measurements were carried out. Additional thermo-dynamical monitoring took place at selected sites. After presenting the different types of measurements, some examples are given to illustrate the potential of the observations made.
The gene encoding the LIM and SH3 domain protein (LASP1) was cloned two decades ago from a cDNA library of breast cancer metastases. As the first protein of a class comprising one N-terminal LIM and one C-terminal SH3 domain, LASP1 founded a new LIM-protein subfamily of the nebulin group. Since its discovery LASP1 proved to be an extremely versatile protein because of its exceptional structure allowing interaction with various binding partners, its ubiquitous expression in normal tissues, albeit with distinct expression patterns, and its ability to transmit signals from the cytoplasm into the nucleus. As a result, LASP1 plays key roles in cell structure, physiological processes, and cell signaling. Furthermore, LASP1 overexpression contributes to cancer aggressiveness hinting to a potential value of LASP1 as a cancer biomarker. In this review we summarize published data on structure, regulation, function, and expression pattern of LASP1, with a focus on its role in human cancer and as a biomarker protein. In addition, we provide a comprehensive transcriptome analysis of published microarrays (n=2,780) that illustrates the expression profile of LASP1 in normal tissues and its overexpression in a broad range of human cancer entities.
Für viele hämatopoetische Erkrankungen, wie Lymphome oder Leukämien, stellt die allogene Stammzelltransplantation auch heute noch die einzige Heilungschance dar. Dabei ist der Wiederaufbau des Immunsystems nach der Transplantation von essentieller Bedeutung für das Überleben der Patienten. In dieser Arbeit wurden 27 Patienten nach allogener Stammzelltransplantation an vier definierten Messzeitpunkten (Tag 30, 60, 90 und 120 nach Transplantation) auf ihre Immunrekonstitution hin untersucht und die dabei erhobenen Daten auf gemeinsame Verläufe und eine mögliche Korrelation zur Klinik der Patienten untersucht.
Die Zellen wurden dabei anhand ihrer Oberflächenmarker gefärbt und mittels Durchflusszytometrie gemessen. Um spezifische T-Zellen zu detektieren, wurden die Zellen zusätzlich vor dem Färben über Nacht mit spezifischen Peptiden stimuliert und dann ihre IFNgamma – Produktion gemessen. Zur Messung der Tregs wurde ein spezielles Kit zur Färbung des Markers Foxp3 verwendet.
Es zeigte sich dabei, dass die NK-Zellen die „erste Welle“ der Immunrekonstitution darstellen, die T-Zellen erholen sich dagegen erst später als eine Art „zweite Welle“. CD8+ zytotoxische T-Zellen sind bei den Patienten gegenüber CD4+ T – Helferzellen über den gesamten Beobachtungszeitraum hinweg dominant, genau umgekehrt zu Gesunden. Die B-Zellen stellten konstant die niedrigste und sich am langsamsten regenerierende Population dar, bei kleineren untersuchten Zellpopulationen war kein einheitlicher Verlauf erkennbar. Diese Daten zeigen, dass das angeborene Immunsystem im Zeitraum nach Transplantation den Hauptschutz für die Patienten bietet, während sich das adaptive Immunsystem in seiner Größe und Funktionsfähigkeit erst über eine sehr viel längere Zeit hinweg erholt und erst später wieder die Hauptschutzfunktion für den Organismus übernehmen kann.
Gängige Beschreibungen von T – Zellsubpopulationen, den central und effector memory T-Zellen nach Sallusto und Rezvani, die in der Literatur gleichbedeutend verwendet werden, lassen sich in einem Kollektiv mit stammzelltransplantierten Patienten nicht zur Deckung bringen.
Bei der Rekonstitution von spezifischen T-Zellen konnten im Beobachtungszeitraum von 120 Tagen keine Antworten auf die Stimulation mit tumorspezifischen Peptiden gezeigt werden, eine Reaktion auf die Stimulation mit CMV – Peptiden war bei fünf Patienten zu erkennen, wobei dies nur bei Patienten der Fall war, die einen CMV positiven Stammzellspender aufwiesen, was als Voraussetzung für eine schnelle CMV spezifische T-Zellimmunrekonstitution anzusehen ist. Deshalb sollte zukünftig noch stärker auf die Auswahl der Stammzellspender bei der allogenen Stammzelltransplantation geachtet werden, um den Empfängern möglichst optimale Voraussetzungen für eine schnelle T – Zellrekonstitution und so einen möglichenen Schutz gegen eine CMV-Reaktivierung zu bieten.
Bei der Rekonstitution der Tregs konnte in diesem Patientenkollektiv keine Korrelation zwischen ihrem Verlauf oder ihrer Anzahl und der Entwicklung einer GvHD oder Infektion gezeigt werden. Diese Tatsache deutet darauf hin, dass die bisher erhobenen Daten, die stets in Kollektiven mit engen Einschlusskriterien und oft ähnlichen Konstellationen was Spender und Empfänger angeht, nicht auf alle Stammzelltransplantationspatienten und Spender übertragbar sind. Es sollte daher zukünftig in größeren repräsentativen Kollektiven eine erneute Untersuchung der regulatorischen T-Zellen erfolgen.
Auch zukünftig wird die Immunrekonstitution nach Stammzelltransplantation Gegenstand vieler Studien bleiben, um so die Voraussetzungen für und das Outcome nach der Transplantation für die Patienten ständig zu verbessern. In der vorgelegten Arbeit konnte gezeigt werden, dass die bisher in der Literatur erhobenen Ergebnisse auf ein heterogenes Fremdspenderkollektiv ohne spezielle Einschlusskriterien, wie es also der Situation im klinischen Alltag am nächsten kommt, nicht übertragbar sind, sondern sich vielmehr wesentliche Unterschiede ergeben. Es sollte daher in zukünftigen Untersuchungen ein Augenmerk auf die Verwendung repräsentativerer Kollektive für die klinische Realität geachtet werden.
Analysis of a multi-component multi-stage malaria vaccine candidate—tackling the cocktail challenge
(2015)
Combining key antigens from the different stages of the P. falciparum life cycle in the context of a multi-stage-specific cocktail offers a promising approach towards the development of a malaria vaccine ideally capable of preventing initial infection, the clinical manifestation as well as the transmission of the disease. To investigate the potential of such an approach we combined proteins and domains (11 in total) from the pre-erythrocytic, blood and sexual stages of P. falciparum into a cocktail of four different components recombinantly produced in plants. After immunization of rabbits we determined the domain-specific antibody titers as well as component-specific antibody concentrations and correlated them with stage specific in vitro efficacy. Using purified rabbit immune IgG we observed strong inhibition in functional in vitro assays addressing the pre-erythrocytic (up to 80%), blood (up to 90%) and sexual parasite stages (100%). Based on the component-specific antibody concentrations we calculated the IC50 values for the pre-erythrocytic stage (17–25 μg/ml), the blood stage (40–60 μg/ml) and the sexual stage (1.75 μg/ml). While the results underline the feasibility of a multi-stage vaccine cocktail, the analysis of component-specific efficacy indicates significant differences in IC50 requirements for stage-specific antibody concentrations providing valuable insights into this complex scenario and will thereby improve future approaches towards malaria vaccine cocktail development regarding the selection of suitable antigens and the ratios of components, to fine tune overall and stage-specific efficacy.
Analysis of discretization schemes for Fokker-Planck equations and related optimality systems
(2015)
The Fokker-Planck (FP) equation is a fundamental model in thermodynamic kinetic theories and
statistical mechanics.
In general, the FP equation appears in a number of different fields in natural sciences, for instance in solid-state physics, quantum optics, chemical physics, theoretical biology, and circuit theory. These equations also provide a powerful mean to define
robust control strategies for random models. The FP equations are partial differential equations (PDE) describing the time evolution of the probability density function (PDF) of stochastic processes.
These equations are of different types depending on the underlying stochastic process.
In particular, they are parabolic PDEs for the PDF of Ito processes, and hyperbolic PDEs for piecewise deterministic processes (PDP).
A fundamental axiom of probability calculus requires that the integral of the PDF over all the allowable state space must be equal to one, for all time. Therefore, for the purpose of accurate numerical simulation, a discretized FP equation must guarantee conservativeness of the total probability. Furthermore, since the
solution of the FP equation represents a probability density, any numerical scheme that approximates the FP equation is required to guarantee the positivity of the solution. In addition, an approximation scheme must be accurate and stable.
For these purposes, for parabolic FP equations on bounded domains, we investigate the Chang-Cooper (CC) scheme for space discretization and first- and
second-order backward time differencing. We prove that the resulting
space-time discretization schemes are accurate, conditionally stable, conservative, and preserve positivity.
Further, we discuss a finite difference discretization for the FP system corresponding to a PDP process in a bounded domain.
Next, we discuss FP equations in unbounded domains.
In this case, finite-difference or finite-element methods cannot be applied. By employing a suitable set of basis functions, spectral methods allow to treat unbounded domains. Since FP solutions decay exponentially at infinity, we consider Hermite functions as basis functions, which are Hermite polynomials multiplied by a Gaussian.
To this end, the Hermite spectral discretization is applied
to two different FP equations; the parabolic PDE corresponding to Ito processes, and the system of hyperbolic PDEs corresponding to a PDP process. The resulting discretized schemes are analyzed. Stability and spectral accuracy of the Hermite spectral discretization of the FP problems is proved. Furthermore, we investigate the conservativity of the solutions of FP equations discretized with the Hermite spectral scheme.
In the last part of this thesis, we discuss optimal control problems governed by FP equations on the characterization of their solution by optimality systems. We then investigate the Hermite spectral discretization of FP optimality systems in unbounded domains.
Within the framework of Hermite discretization, we obtain sparse-band systems of ordinary differential equations. We analyze the accuracy of the discretization schemes by showing spectral convergence in approximating the state, the adjoint, and the control variables that appear in the FP optimality systems.
To validate our theoretical estimates, we present results of numerical experiments.
Das Ziel dieser Arbeit war die Herstellung von Diamantmaterialien, deren Oberflächen mit Alkinen, Aziden oder Aldehyden modifiziert waren. Diese funktionellen Gruppen sollten die einfache Anbindung verschiedener katalytisch aktiver Systeme mit Hilfe der 1,3-dipolaren Cycloaddition nach Huisgen bzw. Iminbildung ermgöglich.
Da in einer vorangegangenen Arbeit Hinweise darauf gefunden wurde, dass die hochgradig funktionalisierte Oberfläche von Detonationsnanodiamant dazu in der Lage ist, die Aktivität von immobilisierten Katalysatoren zu behindern. Darum wurde in dieser Arbeit verglichen, ob die Verwendung von starren Linkern auf Tolanbasis einen Vorteil gegenüber ihren flexiblen Gegenstücken liefert. Dazu wurde für jede der oben genannten Funktionalisierungsarten je ein Diamantmaterial mit flexibler sowie mindestens eines mit unbiegsamer Verbindungseinheit hergestellt und getestet. Dadurch konnte das Konzept der starren Linker für Enzyme bestätigt werden und es wurde eine signifikant höhere Aktivität erhalten, als wenn flexible Anbindungsbrücken verwendet wurden. Bei Organokatalysatoren und metallorganischen Systemen konnten jedoch keine erfolgreichen Katalysen durchgeführt werden.
This review outlines the most frequently used rodent stroke models and discusses their strengths and shortcomings. Mimicking all aspects of human stroke in one animal model is not feasible because ischemic stroke in humans is a heterogeneous disorder with a complex pathophysiology. The transient or permanent middle cerebral artery occlusion (MCAo) model is one of the models that most closely simulate human ischemic stroke. Furthermore, this model is characterized by reliable and well-reproducible infarcts. Therefore, the MCAo model has been involved in the majority of studies that address pathophysiological processes or neuroprotective agents. Another model uses thromboembolic clots and thus is more convenient for investigating thrombolytic agents and pathophysiological processes after thrombolysis. However, for many reasons, preclinical stroke research has a low translational success rate. One factor might be the choice of stroke model. Whereas the therapeutic responsiveness of permanent focal stroke in humans declines significantly within 3 hours after stroke onset, the therapeutic window in animal models with prompt reperfusion is up to 12 hours, resulting in a much longer action time of the investigated agent. Another major problem of animal stroke models is that studies are mostly conducted in young animals without any comorbidity. These models differ from human stroke, which particularly affects elderly people who have various cerebrovascular risk factors. Choosing the most appropriate stroke model and optimizing the study design of preclinical trials might increase the translational potential of animal stroke models.