Refine
Year of publication
- 2023 (1088) (remove)
Document Type
- Doctoral Thesis (481)
- Journal article (447)
- Book article / Book chapter (50)
- Complete part of issue (40)
- Working Paper (27)
- Book (10)
- Preprint (9)
- Master Thesis (6)
- Report (6)
- Conference Proceeding (5)
Language
- English (724)
- German (360)
- Spanish (3)
- Multiple languages (1)
Keywords
- Wuerzburg (41)
- Wurzburg (41)
- Würzburg (41)
- University (40)
- Universität (40)
- machine learning (15)
- cultural studies (14)
- Kulturwissenschaften (12)
- COVID-19 (11)
- deep learning (10)
- SARS-CoV-2 (9)
- Germany (8)
- Tissue Engineering (8)
- Digitalisierung (7)
- Herzinsuffizienz (7)
- Thrombozyt (7)
- anxiety (7)
- India (6)
- Neolithikum (6)
- Schlaganfall (6)
- Topologischer Isolator (6)
- cancer (6)
- inflammation (6)
- mental health (6)
- Angststörung (5)
- Biene (5)
- Brustkrebs (5)
- Chemische Synthese (5)
- Deep learning (5)
- Globalisierung (5)
- Indien (5)
- Lehrerbildung (5)
- Linienbandkeramik (5)
- Maschinelles Lernen (5)
- Parkinson's disease (5)
- Sentinel-2 (5)
- Tumor (5)
- Vulnerabilität (5)
- Zellkultur (5)
- Zellzyklus (5)
- immunotherapy (5)
- metabolism (5)
- neuroinflammation (5)
- platelets (5)
- virtual reality (5)
- Bayern (4)
- Blut-Hirn-Schranke (4)
- CRISPR/Cas9 (4)
- Candida albicans (4)
- Computertomografie (4)
- Deutschland (4)
- Fabry-Krankheit (4)
- Funktionelle Kernspintomografie (4)
- Hall, Stuart (4)
- Künstliche Intelligenz (4)
- Maus (4)
- Medienkompetenz (4)
- Melanom (4)
- Mikroskopie (4)
- Neurodegeneration (4)
- Niereninsuffizienz (4)
- Pflanzen (4)
- Plasmozytom (4)
- Sentinel-1 (4)
- Stammzelle (4)
- T-Lymphozyt (4)
- Virtuelle Realität (4)
- Williams, Raymond (4)
- animal behaviour (4)
- artificial intelligence (4)
- climate change (4)
- global warming (4)
- globalization (4)
- human behaviour (4)
- mRNA (4)
- neuroscience (4)
- prognosis (4)
- psychology (4)
- quality of life (4)
- stroke (4)
- translational research (4)
- 3D cell culture (3)
- 3D-Druck (3)
- ARPES (3)
- Atherosklerose (3)
- Automatisierung (3)
- Biomarker (3)
- Bortezomib (3)
- CRISPR/Cas-Methode (3)
- Cytokine (3)
- Digital Religions (3)
- EEG (3)
- Feminismus (3)
- Glioblastom (3)
- Glioblastoma (3)
- HIV (3)
- Habichtskraut (3)
- Herzinfarkt (3)
- Hypophosphatasie (3)
- Immunologie (3)
- Induzierte pluripotente Stammzelle (3)
- Inklusion <Soziologie> (3)
- Internationalität (3)
- Kernspintomografie (3)
- Kind (3)
- Knochenzement (3)
- Kognition (3)
- Lebensqualität (3)
- Linear Pottery (3)
- MRT (3)
- Magnesiumphosphate (3)
- Makrophage (3)
- Mediendidaktik (3)
- Mehrsprachigkeit (3)
- Modellierung (3)
- Morbus Fabry (3)
- Multiples Myelom (3)
- NK cells (3)
- NLRP3 (3)
- Nebennierenrindenkarzinom (3)
- Neolithic (3)
- Netzhaut (3)
- Organische Synthese (3)
- P4 (3)
- Parkinson’s disease (3)
- Platelet (3)
- Plattenepithelcarcinom (3)
- Regulatorischer T-Lymphozyt (3)
- Religionsunterricht (3)
- Religiöse Bildung (3)
- Rezidiv (3)
- Schistosomiasis (3)
- Simulation (3)
- Small RNA (3)
- Strahlentherapie (3)
- T cells (3)
- Tagung (3)
- Tansania (3)
- Theoretische Chemie (3)
- Ultraschall (3)
- Verhaltensstörung (3)
- Zellskelett (3)
- adrenocortical carcinoma (3)
- altitudinal gradient (3)
- apoptosis (3)
- atrial fibrillation (3)
- bee (3)
- biomarker (3)
- black holes (3)
- blood-brain barrier (3)
- bone marrow (3)
- breast cancer (3)
- cartilage (3)
- cognitive impairment (3)
- critical illness (3)
- cytokines (3)
- deep brain stimulation (3)
- depression (3)
- diagnosis (3)
- eHealth (3)
- education (3)
- fMRI (3)
- feminism (3)
- follow-up (3)
- glioblastoma (3)
- global change (3)
- heart failure (3)
- heart rate (3)
- ischemic stroke (3)
- magnetic resonance imaging (3)
- miRNA (3)
- miRNS (3)
- mortality (3)
- neuroimmunology (3)
- optogenetics (3)
- oxidative stress (3)
- prevention (3)
- remote sensing (3)
- risk stratification (3)
- sepsis (3)
- signaling (3)
- surgery (3)
- tissue engineering (3)
- toe (3)
- tomography (3)
- topological insulators (3)
- tumor microenvironment (3)
- winter wheat (3)
- Übergangsmetallkomplexe (3)
- 3D (2)
- 3D printing (2)
- 3D tissue model (2)
- 5G (2)
- ADHD (2)
- Allgemeines Gleichgewichtsmodell (2)
- Alltagskultur (2)
- Alps (2)
- Altern (2)
- Alzheimerkrankheit (2)
- Anfangsunterricht (2)
- Angiotensin II (2)
- Angst (2)
- Antibiotikum (2)
- Aortenklappenersatz (2)
- Aortenstenose (2)
- Apis mellifera (2)
- Arbeitsplatz (2)
- Archäologie (2)
- Arteriosklerose (2)
- Asteraceae (2)
- Atherosclerosis (2)
- Aufmerksamkeit (2)
- Aufmerksamkeitsprozesse (2)
- Augmented Reality (2)
- Autoantikörper (2)
- B-Zell-Lymphom (2)
- Bavaria (2)
- Behandlung (2)
- Bilderbuch (2)
- Bildverarbeitung (2)
- Bilharziose (2)
- Biofabrication (2)
- Bismut (2)
- Borane (2)
- Borheterocyclen (2)
- Borole (2)
- Borylation (2)
- Borylene (2)
- Brain-derived neurotrophic factor (2)
- CD117 (2)
- CEACAM1 (2)
- CORDEX Africa (2)
- COVID-19 pandemic (2)
- CT angiography (2)
- Calcium (2)
- Calciumphosphat (2)
- Campylobacter jejuni (2)
- Candida (2)
- Candida auris (2)
- Carbene (2)
- Cement (2)
- Chemie (2)
- Chemotherapie (2)
- China (2)
- Chronische Herzinsuffizienz (2)
- Colonkrebs (2)
- Computational Chemistry (2)
- Computertomographie (2)
- Covid-19 (2)
- Cytomegalie-Virus (2)
- Cytoskeleton (2)
- DFT (2)
- DNA (2)
- Datenfusion (2)
- Dendritische Zelle (2)
- Depression (2)
- Deutsch (2)
- Deutsch als Fremdsprache (2)
- Dickdarmkrebs (2)
- Digital Religions Education (2)
- Digital Storytelling (2)
- Dreidimensionale Rekonstruktion (2)
- Dünndarm (2)
- Early Neolithic (2)
- Echinococcus (2)
- Echokardiographie (2)
- Elektrochemie (2)
- Elektrophysiologie (2)
- Endodontie (2)
- Endothel (2)
- Endozytose (2)
- Epigenetik (2)
- Erbrechen (2)
- Ernteertrag (2)
- Erzählen (2)
- Europäische Ethnologie (2)
- Expansion Microscopy (2)
- Expositionstherapie (2)
- Extended Reality (2)
- Exziton (2)
- FcγR (2)
- Fernerkundung (2)
- Fibromyalgie (2)
- Film (2)
- Fluoreszenz (2)
- Fn14 (2)
- Fotophysik (2)
- Fotovoltaik (2)
- Franken (2)
- Fremdsprache (2)
- Furchtgeneralisierung (2)
- GPCR (2)
- Galectine (2)
- Gefühl (2)
- Gephyrin (2)
- German as a foreign language (2)
- Geschlecht (2)
- Google Earth Engine (2)
- Graft-versus-host-disease (2)
- HIV-Infektion (2)
- HNSCC (2)
- Hemibodies (2)
- Herz (2)
- Herzdekompensation (2)
- Herzfrequenz (2)
- Homosexualität (2)
- Immun-Checkpoint (2)
- Immuncytochemie (2)
- Immunhistochemie (2)
- Immunreaktion (2)
- Immunsuppression (2)
- Immunsystem (2)
- Infektion (2)
- Inhibitor (2)
- Inhibitorische Synapse (2)
- Inhibitory synapse (2)
- Inklusiver Unterricht (2)
- Interleukin 6 (2)
- Japan (2)
- Jungneolithikum (2)
- Katalyse (2)
- Keramik (2)
- Kinder (2)
- Kirschner-Draht (2)
- Klima (2)
- Knochenersatz (2)
- Knorpelregeneration (2)
- Kohlenstoff (2)
- Kollagen (2)
- Kolonkarzinom (2)
- Komplexe (2)
- Komplikationen (2)
- Kondo-Effekt (2)
- Kopf-Hals-Tumore (2)
- Korbblütler (2)
- Koronare Herzkrankheit (2)
- Krebs <Medizin> (2)
- Kulturpolitik (2)
- Kulturtheorie (2)
- Kulturwissenschaft (2)
- Körperliche Leistungsfähigkeit (2)
- Landwirtschaft / Nachhaltigkeit (2)
- Larynxkarzinom (2)
- Lehrerfortbildung (2)
- Lehrkräftebildung (2)
- Ligamentum cruciatum anterius (2)
- Linear Pottery Culture (2)
- MAP-Kinase (2)
- MMB (2)
- Machtmissbrauch (2)
- Mammakarzinom (2)
- Marxismus (2)
- Marxist theory (2)
- Massenspektrometrie (2)
- Mausmodell (2)
- Mensch-Maschine-Kommunikation (2)
- Menschenrechte (2)
- Merkel cell carcinoma (2)
- Mesenchymale Stromazellen (2)
- Mesenchymzelle (2)
- Methionin-Restriktion (2)
- Methyltransferase (2)
- Michelsberg culture (2)
- Michelsberger Kultur (2)
- Mitralinsuffizienz (2)
- Modell (2)
- Molekül (2)
- Monarchfalter (2)
- Multiple Myeloma (2)
- Mundhöhlenkrebs (2)
- Musik (2)
- N-heterozyklische Carbene (2)
- NAFLD (2)
- NFATc1 (2)
- Nachhaltigkeit (2)
- Nanometerbereich (2)
- Nanopartikel (2)
- Nationale Minderheiten (2)
- Nebenniere (2)
- Nebennierentumor (2)
- Neisseria gonorrhoeae (2)
- Neugeborenes (2)
- Neurofascin (2)
- Neuroinflammation (2)
- Neuronales Netz (2)
- Neuropathie (2)
- Neurowissenschaften (2)
- Newberyit (2)
- Non-coding RNA (2)
- Nucleinsäuren (2)
- OLED (2)
- Onlinehandel (2)
- Operation (2)
- Organische Chemie (2)
- Organische Solarzelle (2)
- Orientierung (2)
- Osteoporose (2)
- PD-L1 (2)
- PET (2)
- PET/CT (2)
- Parkinson-Krankheit (2)
- Parodontitis (2)
- Peptidsynthese (2)
- Perovskite (2)
- Perowskit (2)
- Phosphoglykolatphosphatase (2)
- Phosphorane (2)
- Photoelektronenspektroskopie (2)
- Photophysics (2)
- Photophysik (2)
- Physikalische Chemie (2)
- Platelets (2)
- Politik (2)
- Polymere (2)
- Positronen-Emissions-Tomografie (2)
- Proteasom (2)
- Pulmonale Hypertonie (2)
- Pädagogik (2)
- Quantenspinsystem (2)
- Quantum information (2)
- RNA (2)
- Radioonkologie (2)
- Rassismus (2)
- Rasterelektronenmikroskopie (2)
- Rastertunnelmikroskop (2)
- Rastertunnelmikroskopie (2)
- Rechtsmedizin (2)
- Religious Education (2)
- Renormierungsgruppe (2)
- Retina (2)
- Ribosom (2)
- Ruthenium complexes (2)
- SDN (2)
- SPECT (2)
- Schwangerschaft (2)
- Sepsis (2)
- Social VR (2)
- Social Virtual Reality (2)
- Sonderpädagogik (2)
- Sozialphilosophie (2)
- Spektroskopie (2)
- Spinale Muskelatrophie (2)
- Spivak, Gayatri Chakravorty (2)
- Sprachsensibilität (2)
- Stakeholder (2)
- Staphylococcus aureus (2)
- Struvit (2)
- Supraleitung (2)
- Supramolekulare Chemie (2)
- Synthese (2)
- Synthesis (2)
- TNF receptor superfamily (2)
- TTFields (2)
- TWEAK (2)
- Tanzania (2)
- Thrombozytenaggregation (2)
- Thrombozytenfunktion (2)
- Toxizität (2)
- Transkriptomanalyse (2)
- Transplantat-Wirt-Reaktion (2)
- Transthorakale Echokardiographie (2)
- Tumortherapiefelder (2)
- Umwelt (2)
- Verhaltensstörungen (2)
- Verkehrsweg (2)
- Vibrationstraining (2)
- Virtual Reality (2)
- Volkskunde (2)
- Vor- und Frühgeschichte (2)
- Winterweizen (2)
- Xiphophorus (2)
- Younger Neolithic (2)
- Zambia (2)
- Zellmigration (2)
- Zement (2)
- abandonment (2)
- accretion (2)
- active zone (2)
- adolescence (2)
- adrenal tumours (2)
- aging (2)
- akute Herzinsuffizienz (2)
- amino acid transporter (2)
- amygdala (2)
- anaesthesiology (2)
- angiogenesis (2)
- animal model (2)
- anxiety disorders (2)
- attention (2)
- auditory pathway (2)
- automation (2)
- autophagy (2)
- basic mental models (2)
- behavior (2)
- blood gas analysis (2)
- bone (2)
- brain (2)
- calcium signaling (2)
- cancer microenvironment (2)
- case report (2)
- cell biology (2)
- cell migration (2)
- central complex (2)
- co-culture (2)
- comorbidity (2)
- computed tomography (2)
- connected mobility applications (2)
- correlation (2)
- cosmology (2)
- crystallization (2)
- cultural politics (2)
- cultural theory (2)
- dSTORM (2)
- decision making (2)
- decision-making (2)
- decoherence (2)
- dementia (2)
- dexamethasone suppression test (2)
- digital change (2)
- discourse analysis (2)
- discriminant analysis (2)
- diseases of the nervous system (2)
- division of labor (2)
- doctoral graduates (2)
- drought stress (2)
- earth observation (2)
- edge states (2)
- editorial (2)
- education for sustainable healthcare (2)
- emergent time (2)
- emotion regulation (2)
- emotional-soziale Entwicklung (2)
- endoscopy (2)
- endurance training (2)
- exercise (2)
- exercise intensity (2)
- extracellular vesicles (2)
- fear (2)
- free electron laser (2)
- gene expression (2)
- general relativity (2)
- genetics (2)
- genomics (2)
- gephyrin (2)
- giant cell arteritis (2)
- glycine receptor (2)
- grading (2)
- guard cells (2)
- health policy (2)
- high-pressure freezing/freeze substitution (2)
- honeybee (2)
- hospitalization (2)
- iPSC-cardiomyocytes (2)
- iPSCs (2)
- imaging (2)
- immunology (2)
- infection (2)
- inflammasome (2)
- innate immunity (2)
- insulin resistance (2)
- internationalism (2)
- intestinal epithelial barrier (2)
- learning (2)
- local field potentials (2)
- magnesium phosphate cement (2)
- malignancy (2)
- management (2)
- mathematical modelling (2)
- media literacy (2)
- medical education (2)
- mesenchymal stromal cells (2)
- metastasis (2)
- methodological pluralism (2)
- migration (2)
- minorities (2)
- monitoring (2)
- motor learning (2)
- movement disorder (2)
- multipath scheduling (2)
- multiple myeloma (2)
- myocardial infarction (2)
- network calculus (2)
- neural network (2)
- neurological disorders (2)
- neurology (2)
- neuromuscular junction (2)
- new subspecies (2)
- obesity (2)
- object detection (2)
- oncology (2)
- ordinary culture (2)
- organoids (2)
- osteoarthritis (2)
- osteoporosis (2)
- pain (2)
- pancreatic cancer (2)
- parasitology (2)
- perception (2)
- performance (2)
- peripheral nervous system (2)
- permafrost (2)
- photon-counting (2)
- physical activity (2)
- platelet (2)
- platelet aggregation (2)
- point-of-care (2)
- politics of representation (2)
- polyneuropathy (2)
- polyomavirus (2)
- positron emission tomography (2)
- pottery (2)
- preclinical research (2)
- prefrontal cortex (2)
- pregnancy (2)
- preterm infants (2)
- principal component analysis (2)
- protease inhibitors (2)
- protein (2)
- protein kinase (2)
- psycho-oncology (2)
- psychoeducation (2)
- public health (2)
- qubit (2)
- racism (2)
- radioiodine (2)
- radiology (2)
- radiotherapy (2)
- radiotherapy (RT) (2)
- reconstruction (2)
- recovery (2)
- regenerative medicine (2)
- regulation (2)
- relativistic jets (2)
- renewable energy (2)
- replication crisis (2)
- review (2)
- rural (2)
- secondary structure (2)
- selenium (2)
- self-assembly (2)
- sex differences (2)
- sexuelle Gewalt (2)
- signaling pathway (2)
- simulation (2)
- single-cell RNA sequencing (2)
- social philosophy (2)
- software (2)
- sphingolipids (2)
- spinal muscular atrophy (2)
- spine (2)
- stress (2)
- survival (2)
- sustainable agriculture (2)
- tapeworm (2)
- technology (2)
- the rich (2)
- three-dimensional imaging (2)
- thrombosis (2)
- traffic route (2)
- transcription (2)
- transcriptome (2)
- transformative education (2)
- transnationalism (2)
- tremor (2)
- tumor (2)
- urban (2)
- urbanization (2)
- very-long-baseline interferometry (2)
- vitamin C (2)
- vitamin D (2)
- wind speed (2)
- zinc (2)
- (approximate) functional equation (1)
- 1,2-Azaborinine (1)
- 1,2-azaborinine (1)
- 131I (1)
- 133Ba (1)
- 17ßEstradiol (1)
- 18S rRNA (1)
- 19. Jahrhundert (1)
- 2,4 DNP (1)
- 223Ra (1)
- 224Ra (1)
- 2C-values (1)
- 2PI Formalism (1)
- 2n+3 (1)
- 2ϕ\(_0\) periodicity (1)
- 3 D bioprinting (1)
- 3 dimensional cell culture model (1)
- 3D Gewebemodelle (1)
- 3D Printing (1)
- 3D Pulverdruck (1)
- 3D Reconstruction (1)
- 3D breast cancer model (1)
- 3D image analysis (1)
- 3D in vitro model (1)
- 3D model generation (1)
- 3D organoids (1)
- 3D-Rekonstruktion (1)
- 3D-Zellkultur (1)
- 3D-konformaler Bolus (1)
- 4D-GIS (1)
- 5A-Gesprächskonzept (1)
- 5G core network (1)
- 6G (1)
- 7,8-Dihydroxyflavon (1)
- 7,8-dihydroxyflavone (1)
- 77-LH-28-1 (1)
- 9-borafluorene (1)
- A. thaliana (1)
- ABA (1)
- ABC-Transporter (1)
- AC-Stabilisierung (1)
- ACC (1)
- ACC/AHA classification (1)
- ACL construct (1)
- ADHD patients (1)
- ADSCs (1)
- AGP (1)
- AHF-Register Würzburg (1)
- AKT1 (1)
- ALMT (1)
- AMADEUS (1)
- AMPK (1)
- AOM/DSS (1)
- AQP4 (1)
- ARDS (1)
- ARMS-PCR (1)
- ATF4 (1)
- ATPase activity (1)
- ATR-FTIR (1)
- ATSSSS (1)
- Ab-initio-Rechnung (1)
- Ableitung (1)
- Academic Skills (1)
- Accessibility (1)
- Accurate crop monitoring (1)
- Acetessigester (1)
- Acetoacetat (1)
- Achilles tendinopathy (1)
- Ackerschmalwand (1)
- Acne inversa (1)
- Acromioclavicular Joint (1)
- Acromioclavicular joint dislocation (1)
- Acromioclaviculargelenkssprengung (1)
- Actin cytoskeleton-related protein (1)
- Activist Scholarship (1)
- Acylcarnitin (1)
- AdS-CFT-Korrespondenz (1)
- AdS/CFT correspondence (1)
- Add-on-Miss (1)
- Additive Fertigung (1)
- Addukt (1)
- Adenoviraler Gentransfer (1)
- Aderhaut (1)
- Adiabatic Perturbation Theory (1)
- Adipositas (1)
- Adjuvans (1)
- Adrenocortical Carcinoma (1)
- Advance Care Planning (1)
- Adverse Outcome Pathway (1)
- Affinity probe (1)
- Agalsidase (1)
- Agamospermy (1)
- Agentenbasierte Modellierung (1)
- Aggression (1)
- Agoraphobie (1)
- Agrobacterium (1)
- Akademische Medizin (1)
- Akademisierung (1)
- Akromioklavikulargelenk (1)
- Akteure (1)
- Aktivierungsenergie (1)
- Aktivist (1)
- Aktivität (1)
- Akute Ösophagusnekrose (1)
- Akzeptanz (1)
- Akzeptanz- und Commitment Therapie (1)
- Aldehyde Bioconjugation (1)
- Alkalimetall (1)
- Alkalische Phosphatase (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Allgemeinmedizin (1)
- Allogenes Knochenersatzmaterial (1)
- Allogenic hematopoietic stem cell transplantation (1)
- Allorhizobium vitis (1)
- Alternative zum Tierversuch (1)
- Altersdepression (1)
- Altersrente (1)
- Altersruhegeld (1)
- Aluminium (1)
- Aluminium(I)-Verbindungen (1)
- Alveolar-ridge-preservation (1)
- Alveolarkamm (1)
- Alzheimer's Dementia (1)
- Alzheimer's disease (1)
- AmGr1 (1)
- AmGr1, AmGr2, AmGr3 (1)
- AmGr2 (1)
- AmGr3 (1)
- American Studies (1)
- American Thyroid Association (1)
- Amerikanistik (1)
- Aminotroponiminate (1)
- Amtshaftung (1)
- Amygdala (1)
- Analogschaltung (1)
- Analytical Quality by Design (1)
- Anatomie (1)
- Anderson impurity model (1)
- Androgendeprivation (1)
- Aneurysmaoperation (1)
- Angewandte Mathematik (1)
- Angiogenese (1)
- Angst als Zustand (1)
- Angsterkrankung (1)
- Angsterkrankungen (1)
- Animal model (1)
- Anitkörpertherapie (1)
- Anode (1)
- Anrege-Abfrage-Spektroskopie (1)
- Anterior Cruciate Ligament (1)
- Anthropozän (1)
- Antibiotic stewardship (1)
- Antibiotikaresistenzen (1)
- Antiferromagnet (1)
- Antiferromagnetikum (1)
- Antiferromagnetismus (1)
- Antikörper (1)
- Antimikrobielle Resistenz (1)
- Antimikrobieller Wirkstoff (1)
- Antimykotikaresistenz (1)
- Anxiety (1)
- Anxiety disorder (1)
- Anxiety disorders (1)
- Anämie (1)
- Aortenaneurysma (1)
- Aortenklappe (1)
- Aortenklappenstenose (1)
- Aortic valve replacement (1)
- Aortic valve stenosis (1)
- Apoptosis (1)
- Appendizitis (1)
- Aquinas (1)
- Arbeitsbedingungen (1)
- Arbeitsmarkt (1)
- Arbeitsprozess (1)
- Arctic (1)
- Argentina (1)
- Armutsviertel (1)
- Arrhythmie (1)
- Arrhythmogene Kardiomyopathie (1)
- Arrhythmogenic cardiomyopathy (1)
- Arthroseentstehung (1)
- Artificial Intelligence (1)
- Arzneimitteldesign (1)
- Arzneimittelüberwachung (1)
- Arzneistoffanalytik (1)
- Asc-1 transporter (1)
- Aspergillus fumigatus (1)
- Astrochemie (1)
- Atemwege (1)
- Atemwegsschleimhaut (1)
- Atherogenese (1)
- Atmungskette (1)
- Attentional bias (1)
- Audiologie (1)
- Audiometrie (1)
- Auditory brainstem implant (1)
- Aufmerksamkeitsdefizit-Syndrom (1)
- Auger-Spektroskopie (1)
- Augmented Lagrangian methods (1)
- Aurora-A (1)
- Aurora-A-MYCN-Komplex (1)
- Ausdauerleistungsdiagnostik (1)
- Ausdauersport (1)
- Ausschreibungen (1)
- Autofluoreszenz (1)
- Autoinhibition (1)
- Automation (1)
- Automatisiertes Fahren (1)
- Autonome technische Systeme (1)
- Autonomer Roboter (1)
- Autonomes Fahrzeug (1)
- Autonomie (1)
- Autophagie (1)
- Awareness (1)
- B cell (1)
- B cell maturation (1)
- B cell receptor (1)
- B cell receptor (BCR) (1)
- B-MYB (1)
- BDNF (1)
- BDNF stimulation (1)
- BMP signaling (1)
- BOLD signal (1)
- BPM (1)
- BPMN (1)
- BRET (1)
- Bacterial infection (1)
- Bafilomycin (1)
- Baghdadit (1)
- Baghdadite (1)
- Bakterielle Infektion (1)
- Bamboo-branch songs (1)
- Bandstruktur (1)
- Bandwürmer (1)
- Bank credit (1)
- Bank-led Growth (1)
- Barbituric Acid Merocyanines (1)
- Barium-133 (1)
- Barth syndrome (1)
- Baryogenesis (1)
- Baryonenasymmetrie (1)
- Batterie (1)
- Bauchspeicheldrüse (1)
- Bauchspeicheldrüsenkrebs (1)
- Baumhöhle (1)
- Bayern (Nord) (1)
- Beamtenrecht (1)
- Beckenkammtransfer (1)
- Bed nucleus of stria terminalis (1)
- Begabtenförderung (1)
- Behandlungsdauer (1)
- Behandlungswechsel von Agalsidase beta zu Agalsidase alfa (1)
- Behinderung (1)
- Beleibtheit (1)
- Beliefs (1)
- Benutzererlebnis (1)
- Benutzerforschung (1)
- Benzimidazolderivate (1)
- Beratungsgespräch (1)
- Beratungssicherheit (1)
- Bereaved Parents (1)
- Bericht (1)
- Berichterstattung (1)
- Berufserfolg (1)
- Beryllafluorene (1)
- Beryllium (1)
- Beryllole (1)
- Beschäftigung (1)
- Bestärkendes Lernen <Künstliche Intelligenz> (1)
- Bestäubung (1)
- Beta-Hydroxybutyrat (1)
- Betreuung (1)
- Betreuungsverfügung (1)
- Betriebsformenwandel (1)
- Bewegungsförderung (1)
- Bias correction (1)
- Bias-Korrektur (1)
- Biene <Gattung> (1)
- Bienenkrankheiten (1)
- Bienenschwarm (1)
- Bikuspide Aortenklappe (1)
- Bildbetrachtung (1)
- Bilderzeugung (1)
- Bildgebendes Verfahren (1)
- Bildinterpretation (1)
- Bildung (1)
- Bimolekulare Lipidschicht (1)
- Bindegewebe (1)
- Bindungsaktivierung (1)
- Bindungsaktivierungen (1)
- Bioaktivität (1)
- Bioconjugate (1)
- Bioinformatics (1)
- Biologie (1)
- Biologische Aktivität (1)
- Biomacromolecular Sensing (1)
- Biomechanics (1)
- Biomechanik (1)
- Bioorthogonal Tag (1)
- Bioreactor (1)
- Bioresorption (1)
- Biosensor (1)
- Biosphere Reserves (1)
- Biosphärenreservat (1)
- Bioverfügbarkeit (1)
- Biozement (1)
- Biradikal (1)
- Biscarbenoide (1)
- Bisexualität (1)
- Bismuthene (1)
- Bispecific T-cell engager (1)
- Bitopische Liganden (1)
- Blei (1)
- Bleiakkumulator (1)
- BlessU2 (1)
- Blick (1)
- Blinddarmentzündung (1)
- Bloch-Floquet Theorem (1)
- Blood nerve barrier (1)
- Blood-Brain-Barrier (1)
- Bodenfeuchte (1)
- Bodenhydrologie (1)
- Bone-replacement (1)
- Bor (1)
- Borcluster (1)
- Boron (1)
- Boron Materials (1)
- Boron heterocycles (1)
- Borylanion (1)
- Borylen (1)
- Borylencarbonyle (1)
- Borylierung (1)
- Boğazkale (1)
- Boğazköy (1)
- Brassicaceae (1)
- Breastcancer (1)
- Brombeere (1)
- Brownsche Bewegung (1)
- Bruxismus (1)
- Bulk-boundary correspondence (1)
- Burkholderia pseudomallei Mip (1)
- Burkitt lymphoma (1)
- Burkitt lymphoma (BL) (1)
- Burley (1)
- Butyrate <Buttersäuresalze> (1)
- Bypass (1)
- C-C coupling (1)
- C1q/TNF related protein (CTRP) (1)
- C5a (1)
- C5aR1 (1)
- CA3 (1)
- CACO-2 (1)
- CAD-CAM (1)
- CAR T cell (1)
- CAR-T cells (1)
- CCR2 (1)
- CCR4 (1)
- CD19 (1)
- CD28 Superagonist (1)
- CDI (1)
- CDL (1)
- CEA (1)
- CED (1)
- CHAC1 (1)
- CHI Conference (1)
- CI (1)
- CIDP (1)
- CIED malfunction; pacemaker (PM) (1)
- CIPK23 (1)
- CK5 (1)
- CMV (1)
- CMV-Reaktivierung (1)
- CNS disorders (1)
- CNS integrity (1)
- CNTF Sehnerv Retina Degeneration (1)
- CNTF optic nerve retina degeneration (1)
- CNV (1)
- COVID-19-ARDS (1)
- COVID‐19 (1)
- CPFE (1)
- CRISPR Cas9 (1)
- CSF-1-Rezeptor-Inhibitor (1)
- CT (1)
- CT-scan (1)
- CVD (1)
- CVD-Verfahren (1)
- CVT (1)
- CXCL10 (1)
- CXCR4 (1)
- CXorf44 (1)
- CYP24A1 (1)
- CYP7A1 (1)
- Ca2+ signal (1)
- CaCo-2 (1)
- Caco2 cells (1)
- Cadherine (1)
- Calcium Phosphate (1)
- Calciumhydroxid (1)
- Calciummagnesiumphosphat (1)
- Calciummagnesiumphosphat-Keramik (1)
- Calciumtransport (1)
- Calu-3 (1)
- Cambrian (1)
- Cancer (1)
- Carben-Boran-Addukte (1)
- Carbenoide (1)
- Carbocistein (1)
- Carbon additives (1)
- Carbon surface chemistry (1)
- Cas9 (1)
- Catalysis (1)
- Causality (1)
- Cayley graph (1)
- Cefotaxim (1)
- Cell adhesion (1)
- Cell cycle (1)
- Cephalosporine (1)
- Ch'i-kung (1)
- Change Vector Analysis (1)
- Characterization (1)
- Charcot-Marie-Syndrom (1)
- Charcot-Marie-Tooth (1)
- Charged Aerosol Detection (1)
- Charged aerosol detection (1)
- Checkpoint-Inhibitor (1)
- Chemical Synthesis (1)
- Chemical modification (1)
- Chemische Bindung (1)
- Chemische Reinheit (1)
- Chemokin CXCL12 (1)
- Children (1)
- Chimäre DNS (1)
- Chimärismusdiagnostik (1)
- Chinese Population Policy (1)
- Chinese state media (1)
- Chinolon <2-> (1)
- Chinolonamide (1)
- Chiralität <Chemie> (1)
- Chirurgie (1)
- Chlorit (1)
- Chloroquin (1)
- Cholesterinstoffwechsel (1)
- Choroidea (1)
- Christentum (1)
- Chromatin (1)
- Chromatographie (1)
- Chronische Niereninsuffizienz (1)
- Chronophin (1)
- Circadian (1)
- Circumpolar (1)
- Cisplatin (1)
- Click-Chemie (1)
- Climate change (1)
- Clitics (1)
- Clostridium difficile (1)
- Clostridium-difficile-Infektion (1)
- Cloud Computing (1)
- Cluster C Persönlichkeitsstörungen (1)
- Cluster C personality disorders (1)
- Cochlea (1)
- Cochlear-Implantat (1)
- Cochrane Review (1)
- Cognitive Remediation (1)
- Cognitive control (1)
- Coherent Multidimensional Spectroscopy (1)
- Coherent perfect absorption (1)
- Coisotropic reduction (1)
- Colorectal Cancer (1)
- Combustion (1)
- Comorbidity (1)
- Composite optimization problems (1)
- Compressed Sensing (1)
- Computed Tomography (1)
- Computer Vision (1)
- Concealed Information Test (CIT) (1)
- Conformal field theory (1)
- Conical Intersections (1)
- Contactin-1 (1)
- Containerization (1)
- Contributors (1)
- Corpus amygdaloideum (1)
- Correlated Fermions (1)
- Correlation Effects (1)
- Correlative microscopy (1)
- Covalent Organic Framework (1)
- Covid-19 Pandemie (1)
- Covid-19 pandemic (1)
- Cox proportional regression analysis (1)
- Coxarthrose (1)
- Coxiella burnetii (1)
- Critical Care (1)
- Crohn-Krankheit (1)
- Crop Growth Models (1)
- Crop YIelds (1)
- Crop growth models (CGMs) (1)
- Crop yield estimations (1)
- Crosslinker (1)
- Crosstalk (1)
- CuMnSb (1)
- Cuneiform text (1)
- Cyaninfarbstoff (1)
- Cyclische Verbindungen (1)
- Cyclisches Nucleotid Phosphodiesterase <3,5-> (1)
- Cyclopenten-4-yl-Kationen (1)
- Cyclotrimerization (1)
- Cyclotriphosphiran (1)
- Cytotoxic T cell (1)
- Cytotoxicity (1)
- Cytotoxizität (1)
- DAS28 (1)
- DASH (1)
- DBS biomarkers (1)
- DBS programming (1)
- DEUQUA (1)
- DHX30 (1)
- DInSAR (1)
- DMARD (1)
- DNA damage repair (1)
- DNA methylation (1)
- DNA recognition (1)
- DNA repair (1)
- DNA storage (1)
- DNA-Sensor (1)
- DNA-based nanostructures (1)
- DNA-processing enzymes (1)
- DNP (1)
- DNS-Reparatur (1)
- DNS-Schädigung (1)
- DRD1 (1)
- DSG2 (1)
- Daily life (1)
- Danaus plexippus (1)
- Darmepithel (1)
- Darmparasit (1)
- Darmparasiten (1)
- Data Fusion (1)
- Datenanalyse (1)
- Dauerfrostboden (1)
- Decision Support Systems (1)
- Deep Learning (1)
- Deep-sequencing (1)
- Deformationsquantisierung (1)
- Degradation (1)
- Demethylase (1)
- Demethylierung (1)
- Dendritische Zellen (1)
- Density of states (1)
- Dental Practice (1)
- Dephosphorylierung (1)
- Depressivität (1)
- Design-Based-Research (1)
- Desinformation (1)
- Detektion (1)
- Deutsche Burschenschaft (1)
- Deutsche Gesellschaft für Hochschulkunde (1)
- Deutsche Studentenschaft (1)
- Development (1)
- Diabetic painful neuropathy (1)
- Diagnostik (1)
- Diamant (1)
- Diastolic Dysfunction (1)
- Diastolische Dysfunktion (1)
- Diazoniumsalze (1)
- Diazoniumverbindungen (1)
- Dibenzoberyllole (1)
- Diboramakrocyclus (1)
- Diboret (1)
- Diboryne (1)
- Dichtefunktionalformalismus (1)
- Dienstrecht (1)
- Differentialgeometrie (1)
- Differentialgleichung (1)
- Diffusion coefficient (1)
- Digital Humanities (1)
- Digital Religions-Unterricht (1)
- Digitale Computertomographie (1)
- Digitale Signalverarbeitung (1)
- Digitale Transformation (1)
- Digitaler Wandel (1)
- Digitalnarrative (1)
- Diine (1)
- Dijkstra’s algorithm (1)
- Diktatur (1)
- Dinitrophenol <2,4-> (1)
- Dinitrophenole (1)
- Diorganobismut-Spezies (1)
- Dirac Halbmetalle (1)
- Dirac semimetals (1)
- Directional emission (1)
- Diskriminierung (1)
- Diskursanalyse (1)
- Distickstoff (1)
- Distickstoff Aktivierung (1)
- Distickstoff Spaltung (1)
- Distress (1)
- Dodecaborane (1)
- Domänenspezifische Sprache (1)
- Doppel-Ganzkörper-CT-Schockraum (1)
- Doppelfiltrationsplasmapherese (1)
- Dorsal root ganglion (1)
- Drahtloses vermaschtes Netzwerk (1)
- Dreiecksgitter (1)
- Drift-Diffusion (1)
- Drosophila melanogaster (1)
- Drug Targeting (1)
- Dual-setting (1)
- Dunkle Persönlichkeitsmerkmale (1)
- Dye (1)
- Dynamic charge acceptance (1)
- Dynamics of ribosome assembly (1)
- Dynamische Molekularfeldtheorie (1)
- Dystonie (1)
- Dünnschichtsolarzelle (1)
- E-Commerce (1)
- E-Food (1)
- E-Government (1)
- E-Grocery (1)
- E-Test (1)
- E-cadherin (1)
- E/T ratio (1)
- E2F2 (1)
- ECMO (1)
- ECMO indication (1)
- ECMO therapy (1)
- ECMO-Therapie (1)
- EGFR (1)
- EHT (1)
- EORTC (1)
- ER dynamics in axon terminals (1)
- ERK1/2-Autophosphorylierung (1)
- ESC Score (1)
- ESIN (1)
- EUROASPIRE (1)
- Earliest LBK (1)
- Earth observation (1)
- Eberhard Karls Universität Tübingen <Motiv> (1)
- Echtes WRF (1)
- Echtzeit (1)
- Ecological Momentary Assessment (1)
- Economic development (1)
- Economic growth (1)
- Edge-MEC-Cloud (1)
- Editorial Principles (1)
- Eeriness (1)
- Effektivität (1)
- Eigenstate Thermalization Hypothesis (1)
- Einflussfaktoren (1)
- Einfühlung (1)
- Einfühlung <Motiv> (1)
- Einsamkeit (1)
- Einzelhandel (1)
- Einzelmolekülmikroskopie (1)
- Einzelzellanalyse (1)
- Eisenmangel (1)
- Electric auditory brainstem response (1)
- Electronic spectroscopy (1)
- Elektromyographie (1)
- Elektronenkorrelation (1)
- Elektronenmikroskopie (1)
- Elektronische Spektroskopie (1)
- Elementarteilchenphysik (1)
- Elementbestimmung (1)
- Elite Controller (1)
- Elternbefragung (1)
- Embryonalentwicklung (1)
- Emission Policy (1)
- Emissions-Computertomographie (1)
- Emmanuel Levinas (1)
- Emotion (1)
- Emotion inference (1)
- Emotionserkennung (1)
- Emotionsinterpretation (1)
- Emotionsregulation (1)
- Empathy (1)
- Empirische Kulturwissenschaft (1)
- Enantioselektivität (1)
- Encephalopathia hepatica (1)
- Endocrinology (1)
- Endocytose (1)
- Endocytosis (1)
- Endokrinologie (1)
- Endophänotypen (1)
- Endoplasmatisches Retikulum (1)
- Endosomes (1)
- Endothelium (1)
- Endotoxämie (1)
- Energieauflösung (1)
- Enhanced Vegetation Index (1)
- Enterobacteriaceae (1)
- Enterococcus faecalis (1)
- Enterococcus faecium (1)
- Entkoppler (1)
- Entscheidungskompetenz (1)
- Entscheidungsunterstützungssystem (1)
- Entwicklung (1)
- Entzündung (1)
- Entzündungsmodell (1)
- Environmental (1)
- Enzym (1)
- Enzymersatztherapie (1)
- Enzymersatztherapie bei Morbus Fabry (1)
- Enzyminhibitor (1)
- Ephedrin (1)
- Epiphyseodese (1)
- Epistemic Network Analysis (1)
- Epistemische Überzeugungen (1)
- Epithelial-mesenchymale Transition (1)
- Epitranskriptom (1)
- Erdbeobachtung (1)
- Erde (1)
- Erdwerk (1)
- Ereignisdatenanalyse (1)
- Erfahrung (1)
- Ermessen (1)
- Ermessensreduktion (1)
- Erneuerbare Energien (1)
- Erosion (1)
- Erratum (1)
- Erregbarkeit (1)
- Erwerbsminderungsrente (1)
- Erziehungswissenschaften (1)
- Erzählung (1)
- Euler equations (1)
- Euler-Lagrange-Gleichung (1)
- Europa (1)
- Europarecht (1)
- European orchard bee (Osmia cornuta) (1)
- Exact Diagonalization (1)
- Excitation-Transcription-Coupling (1)
- Excitatory/inhibitory imbalance (1)
- Exciton–exciton annihilation (1)
- Exosom <Vesikel> (1)
- Experimentelle Psychologie (1)
- Explainable Artificial Intelligence (1)
- Exposure treatment (1)
- Expression (1)
- Extinktion (1)
- Extrazellulärmatrix (1)
- Exzitatorische Synapse (1)
- Exziton-Exziton-Annihilierung (1)
- FAM104A (1)
- FAM104B (1)
- FAT10ylation (1)
- FFPE (1)
- FGF signaling (1)
- FIFO caching strategies (1)
- FLJ14775 (1)
- FLJ20434 (1)
- FOXP2 (1)
- FRET (1)
- FTIR spectroscopy (1)
- Fabaceae (1)
- Fabry (1)
- Fabry disease (1)
- Fabry-Nephropathie (1)
- Fahrfremde Tätigkeit (1)
- Fahrrad (1)
- Fahrradunfall (1)
- Fake News (1)
- Falschmeldung (1)
- Farbstoff (1)
- Fear (1)
- Fear generalization (1)
- Feelings of agency (1)
- Felddetektion (1)
- Feminist (1)
- Femoralarterienplaque (1)
- Femoralplaque (1)
- Feng Menglong (1)
- Fermionensystem (1)
- Fernunterricht (1)
- Festphasensynthese (1)
- Fettleber (1)
- Fettleibigkeit (1)
- Fettsucht (1)
- Fettsäurestoffwechsel (1)
- Fibromyalgia syndrome (1)
- Fibromyalgiesyndrom (1)
- Finance (1)
- Finance-growth nexus (1)
- Finite-Differenzen-Methode (1)
- Flavonoids (1)
- Flight muscle (1)
- Floquet-Theorie (1)
- Flow-Erlebnis (1)
- Flugzeitmassenspektrometrie (1)
- FluidFM (1)
- Fluor(perfluoralkyl)phosphorane (1)
- Fluorescence Microscopy (1)
- Fluorescence and Crosslinking (1)
- Fluorescence microscopy (1)
- Fluorescent probes (1)
- Fluoreszenz-Resonanz-Energie-Transfer (1)
- Fluoreszenzmikroskopie (1)
- Fluoreszenzpolarisation (1)
- Fluoreszenzsonde (1)
- Fluoreszierender Stoff (1)
- Fluorierung (1)
- Fluoro(perfluoroalkyl)phosphoranes (1)
- Follikuläres Lymphom (1)
- Food Retailing (1)
- Forearm fracture (1)
- Forkhead Transcription Factors (1)
- Forkhead-Box-Proteine (1)
- Formulierungsentwicklung (1)
- Fotographie (1)
- FoxO transcription factors (1)
- Fragebogen (1)
- Frailty (1)
- Fraktionierungsmembran (1)
- Franconia (1)
- Frau (1)
- Free Electron Laser (1)
- Freies Molekül (1)
- Friedreich’s ataxia (1)
- Fructosebisphosphat-Aldolase (1)
- Frustrated Lewis Pairs (1)
- Frustrierte Lewis-Paare (1)
- Frühe Gene (1)
- Frühe Neuzeit (1)
- Frühneolithikum (1)
- Frühneolithikum, , , (1)
- Frühstudium (1)
- Fuchsbandwurm (1)
- Fulminsäure (1)
- Functional Renormalization Group (1)
- Functional properties (1)
- Funknetz (1)
- Funktionalisierung <Chemie> (1)
- Funktionswerkstoff (1)
- Furcht (1)
- Furchtentwicklung (1)
- Furchtkonditionierung (1)
- Further Education (1)
- Fusobacterium nucleatum (1)
- Förster Resonance Energy Transfer (1)
- Förster Resonanz Energie Transfer (1)
- Fürsorgepflicht (1)
- G-Protein gekoppelter Rezeptor (1)
- G2/M genes (1)
- GAD1 (1)
- GC1 cells (1)
- GDF-5 (1)
- GDNF (1)
- GEDI (1)
- GEP-NET (1)
- GFAP-Antikörper (1)
- GFAP-antibodies (1)
- GIS (1)
- GLA KO mouse model (1)
- GM-CSF (1)
- GPR54 (1)
- GPVI (1)
- GRAPPA (1)
- GRM8 (1)
- GSH (1)
- GSK3 (1)
- GTP-bindende Proteine (1)
- GaSb/AlAsSb (1)
- Galectin 1 (1)
- Galle (1)
- Gallengangsstenose (1)
- Ganzkörperbestrahlung (1)
- Ganzkörpervibrationstraining (1)
- Ganztag (1)
- Ganztagsbetreuung (1)
- Gas chromatography (1)
- Gaschromatographie (1)
- Gattungstheorie (1)
- Gaussia princeps luciferase (GpL) (1)
- Gebrechlichkeit (1)
- Geburtshilfe (1)
- Geflüchtete (1)
- Gefäßverschluss (1)
- Gehirn (1)
- Gehörmessung (1)
- Geisteswissenschaften (1)
- Geistige Behinderung (1)
- Geld (1)
- Geldpolitik (1)
- Gemeinde (1)
- Gemeinschaftsunterkunft (1)
- Gemüsesaft (1)
- Gender (1)
- Genetic etiology (1)
- Genexpression (1)
- Genomics (1)
- Genotyping (1)
- Genregulation (1)
- Geoinformationssystem (1)
- Geometric constraints (1)
- Geospatial (1)
- Gerichtete Abstrahlung (1)
- German population (1)
- Germinative Zellen (1)
- Geräteentwicklung (1)
- Gesetzliche Krankenversicherung (1)
- Gesprochene Sprache (1)
- Gewalt / Frau (1)
- Gewebekleber (1)
- Gewebemodell (1)
- Gewebemodelle (1)
- Gilroy, Paul: The Black Atlantic (1)
- Gingivitis (1)
- Glasfaserstift (1)
- Global Ecosystem Dynamics Investigation (1)
- Glucocorticoids (1)
- Glucose (1)
- Glukose-Restriktion (1)
- Glut1DS (1)
- Glycocalyx (1)
- Glykane (1)
- Glykobiologie (1)
- Glykokalyx (1)
- Glykosylierung (1)
- Gonorrhoe (1)
- Grad-seq (1)
- Graft versus Leukemia (1)
- Graft-versus-host disease (GvHD) (1)
- Graft-versus-leukemia (1)
- Gram points (1)
- Gram-positive (1)
- Gram’s law (1)
- Granulozyten (1)
- Graphen (1)
- Graptolithoidea (1)
- Graßmannians (1)
- Großtiermodell (1)
- Grubenöfen (1)
- Grundriss (1)
- Grundschule (1)
- Grundschullehrer (1)
- Grundschullehrkräfte (1)
- Grundvorstellung (1)
- Grünland (1)
- Grünlandnutzung (1)
- Guanine nucleotide exchange factor (GEF) (1)
- Guided Endodontics (1)
- GvL (1)
- Gvhd (1)
- Gynäkologie (1)
- H2A histone family member X (H2AX) (1)
- HAND (1)
- HAQ (1)
- HASH (1)
- HBMVEC (1)
- HBMVEC Zellkultur (1)
- HCMV (1)
- HCT-116 (1)
- HCW (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-Rezeptor (1)
- HER2-low (1)
- HIF-1α (1)
- HIIT (High intensity interval training) (1)
- HIPEC (1)
- HIV-associated neurological disorders (1)
- HIV-assoziierte neurologische Erkrankungen (1)
- HIVDR (1)
- HPLC (1)
- HPLC-MS (1)
- HPβCD (1)
- HRT (1)
- HRV (1)
- HT-29 (1)
- Habituationstraining (1)
- Haemophilus haemolyticus (1)
- Haemophilus influenzae (1)
- Hals-Nasen-Ohren-Heilkunde (1)
- Hals-Nasen-Ohren-Tumor (1)
- Hand (1)
- Handdeformität (1)
- Handelsbetrieb / Betriebsform (1)
- Handelsforschung (1)
- Handgelenk (1)
- Handlung (1)
- Handlungserleben (1)
- Handlungsorientierung (1)
- Handlungsregulation (1)
- Handlungssteuerung (1)
- Harnableitung (1)
- Harnwegsinfekt (1)
- Harnwegsinfektion (1)
- Hausgrundrisse (1)
- Hautleitfähigkeit (1)
- Hautmodell (1)
- HeLa-Zelle (1)
- Healing-Response Technik (1)
- Heart failure (1)
- Hecke L-functions (1)
- Hecke eigenforms (1)
- Heisenberg-Modell (1)
- Helicene diimide (1)
- Helicobacter pylori (1)
- Hemibody (1)
- Hepatische Enzephalopathie (1)
- Herpes (1)
- Herzfrequenzvariabilität (1)
- Herzfunktion (1)
- Herzhypertrophie (1)
- Herzmuskel (1)
- Herzmuskelkrankheit (1)
- Heterocyclische Verbindungen (1)
- Heterogenität von Mikroorganismen (1)
- Hethiter (1)
- Heusler (1)
- Heuslersche Legierung (1)
- Hfq (1)
- Hidradenitis suppurativa (1)
- Hieracium (1)
- Hieracium maculatum (1)
- High Resolution (1)
- High-performance liquid chromatography (1)
- Higher-order Transient Absorption Spectroscopy (1)
- Highly automated driving (1)
- Hiperhidrosis (1)
- Hippocampus (1)
- Hirnmetastasen (1)
- Hirntumor (1)
- Hispanoamerikanisch (1)
- Histopathologie (1)
- History (1)
- History of Science (1)
- Hittites (1)
- Hitzeschock-Proteine (1)
- Hochautomatisiertes Fahren (1)
- Hochbegabung (1)
- Hochschulkunde (1)
- Homing (1)
- Honeybee (1)
- Hospitalismus <Hygiene> (1)
- Hubbard model (1)
- Huh6 (1)
- Human Computer Interaction (1)
- Human-centered computing / Access (1)
- Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Mixed / augmented reality (1)
- Human-centered computing / Human computer interaction (HCI) / Interaction paradigms / Virtual reality (1)
- Human-centered computing / Human computer interaction (HCI) / Interactiondevices (1)
- Human-centered computing / Human computerinteraction (HCI) / Interaction techniques (1)
- Humane Afrikanische Trypanosomiasis (1)
- Humanoider Roboter (1)
- Humanparasitologie (1)
- Humanserum (1)
- Hurter (1)
- Hurwitz zeta function (1)
- Hyaliner Knorpel (1)
- Hyaluronsäure (1)
- Hybrid-Molecules (1)
- Hybridliganden (1)
- Hydroarylation (1)
- Hydroxybutyrat <3-> (1)
- Hyperactivity (1)
- Hyperbolische Differentialgleichung (1)
- Hyperhidrose (1)
- Hyperhidrosis (1)
- Hyperkapnie (1)
- Hypernephrom (1)
- Hypertherme Chemotherapie (1)
- Hyperthermie (1)
- Hyperämie (1)
- Hypocrates and Paracelsus (1)
- Hypokrates und Paracelsus (1)
- Hypoparathyreoidismus (1)
- Hypopharynxkarzinom (1)
- Hypophosphatemia (1)
- Hypothalamus (1)
- Hypoxie-induzierbarer Faktor (1)
- Hämodynamik (1)
- Hören (1)
- Hörprothese (1)
- Hörrehabilitation (1)
- Hörscreening (1)
- Hörstörung (1)
- Hüftgelenkarthrose (1)
- Hülsenfrüchte (1)
- ICM cells (1)
- IE3 (1)
- IFNG (1)
- IL-2 (1)
- IL-3 (1)
- IL-4 antagonists (1)
- IL-6 (1)
- ILEX (1)
- IMAZA (1)
- IP3 signaling (1)
- IP6 (1)
- IPOS (1)
- IR spectroscopy (1)
- IR/UV Ion Dip Spectroscopy (1)
- IST (1)
- IT security (1)
- IVIG (1)
- Ibrutinib (1)
- IgD (1)
- IgG4 (1)
- IgM (1)
- Image Quality (1)
- Imipenem (1)
- Imkerei (1)
- Immunadsorption (1)
- Immunantwort (1)
- Immuncheckpointinhibition (1)
- Immune Checkpoint Therapy (1)
- Immune System (1)
- Immune cell assays (1)
- Immunkardiologie (1)
- Immunocardiology (1)
- Immunogenität (1)
- Immunology (1)
- Immunotherapy (1)
- Immuntherapie (1)
- Immunzellassays (1)
- Impfausbildung (1)
- Impfung (1)
- Implantat (1)
- Impulsivität (1)
- Impurity Profiling (1)
- In vitro (1)
- In vivo (1)
- In-vitro-Kultur (1)
- InSAR (1)
- Income (1)
- Index-Hospitalisierung (1)
- Indium (1)
- Induced pluripotent stem cells (1)
- Industrial Policy (1)
- Industrie (1)
- Industrie-Roboter (1)
- Industriepolitik (1)
- Infection models (1)
- Infectious diseases (1)
- Infektiologie (1)
- Infektionen (1)
- Infektionsmodell (1)
- Infektionsprozesse (1)
- Infektionsstudien (1)
- Infrarotspektroskopie (1)
- Inhibition (1)
- Inhibitory-postsynapse (1)
- Injectability (1)
- Inklusion (1)
- Innenbebauung (1)
- Innenohrkrankheit (1)
- Inositoltrisphosphat (1)
- Input-Output-Analyse (1)
- Insekten (1)
- Insektensterben (1)
- Institut für Deutsche Studentengeschichte Würzburg (1)
- Institut für Hochschulkunde Würzburg (1)
- Instrumentelle Analytik (1)
- Integrationshilfe (1)
- Integrationskräfte (1)
- Integrin (1)
- Intensivmedizin (1)
- Interaktion (1)
- Interferon <alpha-2a-> (1)
- Interkulturalität (1)
- Interkulturelle Kompetenz (1)
- Interkulturelles Lernen (1)
- Interleukin 17 (1)
- Interleukin 17-Inhibitor (1)
- Interleukin 2 (1)
- Interleukin 4 (1)
- Interleukin-4 (IL-4) (1)
- Intermolecular Interactions (1)
- Intermolekulare Wechselwirkungen (1)
- Internalisierende Störung (1)
- Internationales Recht (1)
- Internet of Things (1)
- Internet of Things devices (1)
- Intersexualität (1)
- Intervall (1)
- Interventionsradiologie (1)
- Intraoperative Strahlentherapie (1)
- Intravenöse Applikation (1)
- IoT (1)
- IoT-driven processes (1)
- Ischaemic Stroke (1)
- Ischämischer Schlaganfall (1)
- Isolation and Characterization (1)
- Isosteviol-Natrium (1)
- JAK inhibitor (1)
- JCAS (1)
- JOL reactivity (1)
- Jahresbericht (1)
- Jameson, Frederic (1)
- Janus fibers (1)
- Joseph d'Outrepont (1)
- Josephson junctions (1)
- Journal of Nuclear Cardiology (1)
- Judgements of agency (1)
- Judith Butler (1)
- Julius-Maximilians-Universität Würzburg (1)
- Justiz (1)
- Juvenile chronische Arthritis (1)
- K band ranging (KBR) (1)
- K+ channels (1)
- K-Ras (1)
- K-wire (1)
- KEA (1)
- KHK (1)
- KISS1 receptor (1)
- KISS1-54 (1)
- KIT (1)
- KOOS (1)
- Kabellose Netzwerke (1)
- Kakao (1)
- Kantenzustand (1)
- Kanurennsport (1)
- Kapillare (1)
- Kapillarwand-assoziierte Zellen (1)
- Kapselshift (1)
- Kardinalität (1)
- Kardinalzahl (1)
- Kardio-CT (1)
- Kardio-MRT (1)
- Kardiologie (1)
- Kardiovaskuläre Erkrankungen (1)
- Kardiovaskuläre Krankheit (1)
- Kardiovaskuläre Risikofaktoren (1)
- Karikatur (1)
- Karotisarterienplaque (1)
- Karotisplaque (1)
- Karpus (1)
- Karriere (1)
- Kaste (1)
- Kathará (1)
- Katholische Kirche (1)
- Katholische Kirche <Motiv> (1)
- Kehlkopf (1)
- Keilschrifttext (1)
- Keratinozyt (1)
- Kernspinresonanz (1)
- Kernspintomographie (1)
- Ketamin (1)
- Ketonkörper (1)
- KhpB protein (1)
- Ki67 (1)
- Kiefernrindenextrakt (1)
- Kimchi (1)
- Kinaseinhibitor (1)
- Kinder- und Jugendpsychiatrie (1)
- Kinderpsychiatrie (1)
- Kindesalter (1)
- Kinetics (1)
- Kinetik (1)
- Kinetische Gleichung (1)
- Klebstoff (1)
- Kleinhirn (1)
- Klimamodell (1)
- Klinische Studie (1)
- Klinisches Experiment (1)
- Klise (1)
- Klitikon (1)
- Klitisierung (1)
- Kniegelenkarthrose (1)
- Knochenbildung (1)
- Knochenersatzmaterial (1)
- Knocheninfiltration (1)
- Knochenkleber (1)
- Knochenmark (1)
- Knochenmarktransplantation (1)
- Knochenmetastase (1)
- Knochenmetastasen (1)
- Knorpel (1)
- Knorpelintegration (1)
- Knowledge Acquisition (1)
- Knowledge attitudes practices survey (1)
- Kodifikation (1)
- Kodifizierung (1)
- Kognition bei mHE (1)
- Kognitionspsychologie (1)
- Kognitive Psychologie (1)
- Kohlenhydrate (1)
- Kohlenmonoxid (1)
- Kohlenstoffmonoxid (1)
- Kohärente perfekte Absorption (1)
- Kollageninhibition (1)
- Kolloid (1)
- Kolorektales Karzinom (1)
- Kombinationstherapie (1)
- Komfortlaut (1)
- Kommunikationstraining (1)
- Komorbidität (1)
- Komplement <Immunologie> (1)
- Komplementsystem (1)
- Komplikation (1)
- Konjugation (1)
- Konsum (1)
- Kontrastmittel (1)
- Koordinationschemie (1)
- Koordinationslehre (1)
- Koordinationsverbindungen (1)
- Koordinativ ungesättigte Verbindungen (1)
- Koronarangiographie (1)
- Koronararterie (1)
- Koronarnahtsynostose (1)
- Koronarographie (1)
- Korrektur (1)
- Korrelative Mikroskopie (1)
- Kosmochemie (1)
- Krafttraining (1)
- Kraniometrie (1)
- Kraniometrische Vermessung (1)
- Kranioplastik (1)
- Kraniosynostose (1)
- Krankenhaus (1)
- Kreatinin (1)
- Kreatives Schreiben (1)
- Krebsforschung (1)
- Kreuzband (1)
- Kreuzbandersatz (1)
- Kreuzreaktion (1)
- Kristallzüchtung (1)
- Kryoelektronenmikroskopie (1)
- Kultur (1)
- Kulturgut (1)
- Kulturpflanzen (1)
- Kupfer (1)
- Kurdyka--{\L}ojasiewicz property (1)
- Kurzpsychotherapie (1)
- Kutikula (1)
- Körperachsen (1)
- Körperarbeit (1)
- Körperpsychotherapie (1)
- Körpertherapie (1)
- Künstliche Ingelligenz (1)
- LC-Oszillator (1)
- LCA (1)
- LCB (1)
- LCNEC (1)
- LFU (1)
- LPS (1)
- LRU (1)
- LUMEN (1)
- Laborgerät (1)
- Land Use/Land Cover (1)
- Land use diversity (1)
- Landoberfläche-Atmosphäre Interaktion (1)
- Landsat 8 (1)
- Landschaftspflege (1)
- Laryngeale Vorläuferläsionen (1)
- Larynx (1)
- Lasiocarpin (1)
- Lateinamerika (1)
- Ldlr-Knockout (1)
- Lead Time (1)
- Lead-acid batteries (1)
- Lead-free double perovskite (1)
- Lebensmittelchemie (1)
- Lebensmitteleinzelhandel (1)
- Lebensmittelhandel (1)
- Lebensmittelprodukte (1)
- Lebensqualität bei mHE (1)
- Lehramtsstudierende (1)
- Lehrer:innenstimme (1)
- Lehrmodell (1)
- LeishBASEedit (1)
- Leishmania (1)
- Leistung (1)
- Leistungsbewertung (1)
- Leistungsdiagnostik (1)
- Leistungsentwicklung (1)
- Leistungsfähigkeit (1)
- Leitliniengerechte Therapie (1)
- Lepidoptera (1)
- Leptogenesis (1)
- Lerch zeta function (1)
- Lerneffekt (1)
- Lernen (1)
- Lernerfolg (1)
- Lernkurve (1)
- Lerntechnik (1)
- Lernwirksamkeit (1)
- Lessing, Gotthold Ephraim / Minna von Barnhelm, oder das Soldatenglück (1)
- Leukaemia-inhibitory factor (1)
- Lewis acidity (1)
- Lewis-Azidität (1)
- Lewis-Säure (1)
- Library of Phytochemicals (1)
- Library of plant species (1)
- Lidschlag (1)
- Lie group actions (1)
- Lie groups (1)
- Lie n-algebroids (1)
- Lieferzeit (1)
- Lifetime Imaging (1)
- Liganden (1)
- Light use efficiency (LUE) model (1)
- Line of Perpendicularity (1)
- Lineare Optimierung (1)
- Linguistik (1)
- Linux (1)
- Lipoprotein (1)
- Lipoprotein Lp (a) (1)
- Liquordiagnostik (1)
- Literary and Cultural Studies (1)
- Literatur (1)
- Literaturwissenschaft (1)
- Lithium-Ionen-Akkumulator (1)
- Lithium-Ionen-Batterie (1)
- Lithium-ion Battery (1)
- Local (1)
- Local Gazetteer (1)
- Local Lipschitz continuity (1)
- Locomotor activity (1)
- Logistikzentren (1)
- Lokales Wissen (1)
- Low-density-Lipoproteine (1)
- Lower Bavaria (1)
- Lungenembolie (1)
- Lungenkrebs (1)
- Luttinger Materialien (1)
- Luttinger materials (1)
- Lymphknotenmetastase (1)
- Lymphogranulomatose (1)
- Lyso-Gb3 (1)
- Lysosom (1)
- Lysosomale Speicherkrankheit (1)
- Lysosome (1)
- Löslichkeit (1)
- M2 (1)
- M4 (1)
- MACC1 (1)
- MALDI-MS (1)
- MALDI-TOF-MS (1)
- MAPK-Inhibitoren (1)
- MASLD (1)
- MATQ-seq (1)
- MCC950 (1)
- MCMV (1)
- MEK5/ERK5 cascade (1)
- MGL (1)
- MHD equations (1)
- MOD13Q1 (1)
- MODIS (1)
- MP-DCCP (1)
- MRSA (1)
- MS und soziale Medien (1)
- MSC (1)
- MSC 11M35 (1)
- MSC: 14M15 (1)
- MSC: 49M37 (1)
- MSC: 53C22 (1)
- MSC: 53C35 (1)
- MSC: 65K05 (1)
- MSC: 90C30 (1)
- MSC: 90C40 (1)
- MSCT (1)
- MUTYH1 (1)
- MYC (1)
- MYCN (1)
- MYCNv (1)
- Machine Learning (1)
- Macrophages (1)
- Madelung (1)
- Madelung deformity (1)
- Madelung's deformity (1)
- Madelung, Otto Wilhelm (1)
- Madelung-Deformität (1)
- Magnesiumoxid (1)
- Magnetfeldeffekt (1)
- Magnetische Anregung (1)
- Magnetische Störstelle (1)
- Magnetismus (1)
- Magnetohydrodynamische Gleichung (1)
- Magnetpartikelspektroskopie (1)
- Magnetresonanztomographie (1)
- Magnetteilchen (1)
- Majorana-Nullmoden (1)
- Makrocyclische Verbindungen (1)
- Makuladegeneration (1)
- Malat1 (1)
- Malawi (1)
- Malignant melanoma (1)
- Mamestra brassicae (1)
- Mammacarzinom (1)
- Mantle cell lymphoma (1)
- Manuelle visuelle Bildinterpretation (1)
- Maschinelles Sehen (1)
- Massenmedien + Wirkung (1)
- Masspectrometry (1)
- Material Science (1)
- Materialanalytik (1)
- Materialuntersuchung (1)
- Materielle Kultur (1)
- Mathematical Optimization (1)
- Mathematikdidaktik (1)
- Mathematikunterricht (1)
- Mathematische Fähigkeit (1)
- Mathematische Modellierung (1)
- Maximalnetzplan (1)
- Mc4r (1)
- Mechanotransduktion (1)
- Media Literacy (1)
- Medical Education (1)
- Medical Image Analysis (1)
- Medien (1)
- Medien + Psychologie (1)
- Medienpädagogik (1)
- Medienwirkungsforschung (1)
- Medizindidaktik (1)
- Medizinhistoriker (1)
- Medizinische Lehre (1)
- Medizinkritik (1)
- Medizinstudium (1)
- Medizinunterricht (1)
- Megakaryozyt (1)
- Mehrfachbindung (1)
- Mehta, Deepa (1)
- Meige syndrome (1)
- Melodiestruktur (1)
- Melt electrowriting (1)
- Meningeom (1)
- Meniskus (1)
- Meniskuschirurgie (1)
- Meniskusläsion (1)
- Meniskusresektion (1)
- Menière-Krankheit (1)
- Mensch-Maschine-Interaktion (1)
- Mensch-Tier (1)
- Menschenwürde (1)
- Mental Representations (1)
- Mesenchymal Stem Cell (1)
- Mesenchymale Stammzellen (1)
- Mesenchymale Stromazelle (1)
- Metabolic Glycoengineering (1)
- Metabolom (1)
- Metabolome (1)
- Metabolomics (1)
- Metabolomik (1)
- Metallosupramolecular chemistry (1)
- Metallosupramolekulare Chemie (1)
- Metamaterial (1)
- Metastase (1)
- Metaverse (1)
- Meteorologische Muster (1)
- Methionin (1)
- Methode (1)
- Methylierung (1)
- Microbubbles (1)
- Microscopy (1)
- Microwave Assisted Extraction (1)
- Mig1 (1)
- Migration (1)
- Mikrodilutionstest (1)
- Mikroelektronik (1)
- Mikroglia (1)
- Mikrotubuli (1)
- Mikrotubuli-assoziiertes Protein (MAP) (1)
- Milchzahnverlust (1)
- Milieu (1)
- Ming dynasty (1)
- Mingdynastie (1)
- Minipig (1)
- Minoxidil (1)
- Mip (1)
- Mip Inhibitoren (1)
- Mip inhibitor (1)
- Mitochondrialer Uniporter (MCU) (1)
- Mitochondrialer Uniporter Knock out (MCU-KO) (1)
- Mitochondrium (1)
- Mitose (1)
- Mitralklappenfehler (1)
- Mitralklappeninsuffizienz (1)
- Mitralklappenvitium (1)
- Mobbing (1)
- Mobbingstudie (1)
- Modellentwicklung (1)
- Moderator (1)
- Modification (1)
- ModulationTregs (1)
- Molekularbiologie (1)
- Molekulardesign (1)
- Molekulare Bildgebung (1)
- Molekularstrahlepitaxie (1)
- Money (1)
- Monitoring (1)
- Monoklonale Gammopathie (1)
- Monoklonaler bispezifischer Antikörper (1)
- Monolage (1)
- Monolayer (1)
- Monoschicht (1)
- Monte-Carlo (1)
- Morbus Menière (1)
- Mortalität (1)
- Motoneuron (1)
- Motoneuron-Krankheit (1)
- Motorische Fertigkeiten (1)
- Motorische Fähigkeit (1)
- Motorisches Lernen (1)
- Mott-Übergang (1)
- Mulitspezies Studien (1)
- Multi-Loop (1)
- Multi-Unit Aufnahmen (1)
- Multibracket-Apparatur (1)
- Multidrug-Resistenz (1)
- Multidrugresistant (1)
- Multilayered skin tissue model (1)
- Multimorbidität (1)
- Multisensory integration (1)
- Multispecies Studies (1)
- Mundhöhlenkarzinom (1)
- Muscarinrezeptor (1)
- Muscle (1)
- Musikerziehung (1)
- Musikintervall (1)
- Musikunterricht (1)
- Muskarinrezeptor (1)
- Muskelatrophie (1)
- Mutation (1)
- Mutation FKS Hot Spot 1/ERG11 (1)
- Myc (1)
- Mycoplasma pneumoniae (1)
- Myeloid-derived suppressor cells (1)
- Myocardial infarction (1)
- Myokardiale Deformation (1)
- Myokardiale T1ρ-Quantifizierung (1)
- Myokardinfarkt (1)
- Myosin IIA (1)
- Mähen (1)
- México (1)
- Münchshöfen, earthwork (1)
- Münchshöfener Kultur (1)
- N ligands (1)
- N-Glykosylierungsmotive (1)
- N-Heterocyclic Carbenes (1)
- N-functionalization (1)
- N-glycosylation sites (1)
- N-heterocyclic carbenes (1)
- NA (1)
- NAS (1)
- NDVI (1)
- NEDMIAL (1)
- NF-κB (1)
- NF2-related schwannomatosis (NF2) (1)
- NFAT (1)
- NFATc3 (1)
- NFκB (1)
- NGS (1)
- NHX1 (1)
- NIPPV (1)
- NIR chromophore (1)
- NMDAR (1)
- NMJ–neuromuscular junction (1)
- NMOSD (1)
- NMR (1)
- NMR-Spektroskopie (1)
- NOTCH (1)
- NRF2 (1)
- NSG (1)
- NSG-SGM3 (1)
- NSSI (1)
- NaCl transport (1)
- NaV1.9 (1)
- Na\(_V\)1.8 (1)
- Nachbefragung (1)
- Nahrung (1)
- Nano-CT (1)
- Nanodiamant (1)
- Nanooptik (1)
- Nanophotonik (1)
- Naphthacenderivate (1)
- Narrative (1)
- Narrativität (1)
- Narrow escape problem (1)
- Nationale Traditionen (1)
- Nationalsozialistischer Deutscher Studentenbund (1)
- Natriumkanal (1)
- Nature Conservation (1)
- Nature-Insipired Synthesis (1)
- NaturenKulturen (1)
- Naturschutz (1)
- Naturstoff (1)
- Nausea (1)
- Nebenniereninsuffizienz (1)
- Nebennierenrindenkrebs (1)
- Nebenniererindenkarzinom (1)
- Nekrose (1)
- Nephrotoxizität (1)
- Nervenstimulation (1)
- Network Emulator (1)
- Netzplantechnik (1)
- Neuen Geistlichen Gemeinschaften (1)
- Neugeborene (1)
- Neurodevelopmental diseases (1)
- Neuroendokriner Tumor (1)
- Neuroepigenomics (1)
- Neurofibromatose (1)
- Neurofibromatose Typ 2 (1)
- Neurogenese (1)
- Neuroimmunologie (1)
- Neuromodulation (1)
- Neuropathic pain (1)
- Neuropathologie (1)
- Neuroprotection (1)
- Neuroscience (1)
- Neurotrophe Faktoren (1)
- Neutral rate of interest (1)
- Neutrino (1)
- Neutrophils (1)
- Neuzeit (1)
- Nicht-Fulleren Akzeptor (1)
- Nicht-kleinzelliges Bronchialkarzinom (NSCLC) (1)
- Nichtlineare Spektroskopie (1)
- Nickel-Complexes (1)
- Niederbayern (1)
- Niedergelassene Kardiologen (1)
- Niedervalente (1)
- Niedervalente Spezies (1)
- Niedervalente Verbindungen (1)
- Niedervalentes Bor (1)
- Nierenfunktion (1)
- Nierenkrebs (1)
- Nierenzellkarzinom (1)
- Nigeria (1)
- Nikotinentwöhnungsberatung (1)
- Nineteenth Century (1)
- Nisthöhle (1)
- Nociceptor (1)
- Non-Fullerene Acceptor (1)
- Non-Hermitian skin effect (1)
- Non-Hodgkin-Lymphom (1)
- Noonan-Syndrom (1)
- Norbert Groeben (1)
- Northern Bavaria (1)
- Nosokomiale Infektion (1)
- Notfallmedizin (1)
- Nrf 2 (1)
- Nucleobase Surrogate Incorporation (1)
- Nucleoside (1)
- Nucleus Cochlearis (1)
- Nucleus cochlearis anterior (1)
- Nucleus cochlearis posterior (1)
- Nutztierhaltung (1)
- O6-alkylguanine-DNA alkyltransferase (1)
- OLC (1)
- OLFM4 (1)
- OST1 (1)
- Oberes Sprunggelenk (1)
- Oberflächenanalytik (1)
- Oberflächenphysik (1)
- Oberflächenzustand (1)
- Obesity (1)
- Object Detection (1)
- Ockham (1)
- Octopamin (1)
- Octopamine (1)
- Octopaminergic signaling (1)
- Off-Label-Use (1)
- Offset (1)
- Oldenburg burnout inventory (1)
- Olfaktorik (1)
- Oligonucleotide (1)
- Omega-3-Fettsäuren (1)
- Onchocerca volvulus (1)
- Onchozerkose (1)
- Oncogenes (1)
- Oncostatin M (1)
- Onkologie (1)
- Online Food Retailing (1)
- Online-Lebensmitteleinzelhandel (1)
- Open Access (1)
- Open Quantum System (1)
- Operative Therapie (1)
- Optical antenna (1)
- Optische Antenne (1)
- Optogenetics (1)
- Optogenetik (1)
- Orales Plattenepithelkarzinom (1)
- Orbital (1)
- Organischer Halbleiter (1)
- Organoid (1)
- Orphans (1)
- Orthese (1)
- Orthopädie (1)
- Osmolarität (1)
- Osmr-Knockout (1)
- Ossifikation (1)
- Osteoarthritis (1)
- Osteoklast (1)
- Osteolyse (1)
- Osteoporosis (1)
- Oxidative Phosphorylierung (1)
- Oxidativer Stress (1)
- Oxytocin (1)
- Ozon (1)
- P4-INT (1)
- PAG (1)
- PAH formation (1)
- PAP-Abstrich (1)
- PAR-CLIP (1)
- PCD (1)
- PCL (1)
- PCLS (1)
- PCR (1)
- PD-1 (1)
- PD-1/PD-L1 (1)
- PDXP (1)
- PEDOT (1)
- PEFB (1)
- PEG (1)
- PER (1)
- PFA in ethanol (1)
- PGE2 (1)
- PHQ-4 (1)
- PHQ-9 (1)
- PKP2 (1)
- PLGA (1)
- PMMA (1)
- PONV (1)
- PPIase (1)
- PRO (1)
- PROLOG <Programmiersprache> (1)
- PROM (1)
- PROM’s (1)
- PROTAC (1)
- PSMC2 (1)
- PSP (1)
- PT-Transformation (1)
- PTH1R (1)
- Paclitaxel (1)
- Palisade (1)
- Palliativbedarf (1)
- Palliativmedizin (1)
- Palliativpflege (1)
- Pandemie (1)
- Panikstörung (1)
- Pankreas (1)
- Pap-Test (1)
- Papaverin (1)
- Paranodopathie (1)
- Parasitology (1)
- Parodontalerkrankungen (1)
- Parodontalschienung (1)
- Pathogenese (1)
- Pathogenesis (1)
- Pathogenität (1)
- Pathologie (1)
- Pathophysiologie (1)
- Patient Reported Outcome (1)
- Patientenbewusstsein (1)
- Patientenverfügung (1)
- PbSnSe (1)
- Pentafluorethylierung (1)
- Peptide (1)
- Perceived Usefulness (1)
- Perceived Wealth (1)
- Perception (1)
- Perceptions, Attitudes, and Values (1)
- Perfluoralkylierung (1)
- Peripheral eosinophils (1)
- Periphere Stammzellentransplantation (1)
- Peripheres Nervensystem (1)
- Periprothetische Zyste (1)
- Periprothetischer Lysesaum (1)
- Peritonealkarzinose (1)
- Perizyt (1)
- Perlen (1)
- Permafrost (1)
- Persönlichkeitsstörung (1)
- Perturbative (1)
- Perylenbisdicarboximide <Perylen-3,4:9,10-bis(dicarboximide)> (1)
- Pest (1)
- Pesticide (1)
- Peyersche Plaques (1)
- Pflegeheim (1)
- Pflegeheimbewohnende (1)
- Pflegeheimbewohner (1)
- Pflegeheimbewohnerin (1)
- Pflegeroboter (1)
- Pfriemengras (1)
- Pharmaceutical Analysis (1)
- Pharmakokinetik (1)
- Pharmakometrie (1)
- Pharmazeutischer Hilfsstoff (1)
- Phase diagrams (1)
- Phospha-Wittig-Reagenz (1)
- Phosphatase (1)
- Phosphodiesterase 10A (1)
- Phospholipide (1)
- Phosphor (1)
- Phosphoramidite (1)
- Phosphoserin (1)
- Photochemie (1)
- Photodissoziation (1)
- Photoluminescence (1)
- Photoresponsive DNA Crosslinker (1)
- Photoviltaics (1)
- Photovoltaik (1)
- Phylogenie (1)
- Phylogeny (1)
- Physics beyond the Standard Model (1)
- Physikalische Konsistenz (1)
- Physiolyse (1)
- Pilocarpin (1)
- Pilokarpin (1)
- Pilosella macranthela (1)
- Pilosella ottonis (1)
- Pilz (1)
- Place (1)
- Planetary Health (1)
- Planetary Health Education (1)
- Plant extracts (1)
- Plants (1)
- Plaque (1)
- Plasmapherese (1)
- Plasmonik (1)
- Plastin 3 (1)
- Plattenepithelkarzinom (1)
- Platy (1)
- Poisson algebras (1)
- PolSAR (1)
- Policy Implementation in China (1)
- Politische Ethik (1)
- Polycaprolacton (1)
- Polycyclic Aromatic Hydrocarbons (1)
- Polycyclic aromatic hydrocarbons (1)
- Polycyclische Aromaten (1)
- Polycyclische aromatische Kohlenwasserstoffe (1)
- Polyethylenglykol (1)
- Polyethylenglykole (1)
- Polyglycerol (1)
- Polyine (1)
- Polylactid-co-Glycolid (1)
- Polymers (1)
- Polymethylmethacrylate (1)
- Polyneuropathie (1)
- Polyphenole (1)
- Polysaccharide (1)
- Polytrauma (1)
- Populism (1)
- Populismus (1)
- Porosität (1)
- Porous Materials (1)
- Postmarxismus (1)
- Postmortale Liquordiagnostik (1)
- Postoperatives Offset (1)
- Praxis (1)
- Pre-service Teachers (1)
- Predicting (1)
- Pregnancy (1)
- Prevalence (1)
- Primarstufe (1)
- Private Krankenversicherung (1)
- Produktionsplanung (1)
- Prognose (1)
- Programmed Cell Death 1 (1)
- Programmed Cell Death Ligand 1 (1)
- Progressionsrisiko (1)
- Projektseminar (1)
- Proliferation (1)
- Promotion (1)
- Promotor (1)
- Promotorpolymorphismus (1)
- Prosodie (1)
- Prosoziales Verhalten (1)
- Prospektive klinische Verlaufsstudie (1)
- Prostaglandin E2 (1)
- Prostatakrebs (1)
- Prostataspezifisches Membranantigen (1)
- Proteasome (1)
- Proteasomhemmung (1)
- Proteasomsystem (1)
- Protein A-Adsorber (1)
- Protein p53 (1)
- Protein-Protein-Wechselwirkung (1)
- Proteinbindung (1)
- Proteine (1)
- Proteintyrosinphosphatase (1)
- Proteolysis-Targeting-Chimera (1)
- Prothetik (1)
- Protozoa (1)
- Protozoen (1)
- Pruno-Rubion sprengelii (1)
- Präparative organische Chemie (1)
- Prävalenz (1)
- Prävention (1)
- Präventionsmotivation (1)
- Pseudo-Fermions (1)
- Pseudo-WRF (1)
- Pseudouridin (1)
- Psychische Störung (1)
- Psychologie (1)
- Psychoneuroimmunologie (1)
- Psychotherapie (1)
- Publikationsbias (1)
- Pump-Probe-Technik (1)
- Pump–probe spectroscopy (1)
- Punktwolke (1)
- Pyridoxal phosphate phosphatase (1)
- Pyridoxalphosphat (1)
- Pyridoxalphosphat Phosphatase (1)
- Pyrochlore (1)
- Pyrrolizidinalkaloide (1)
- QM (1)
- QM/MM (1)
- Qi Gong (1)
- QoL (1)
- Qualitative Inhaltsanalyse (1)
- Quality Management (1)
- Qualitätsmanagement (1)
- Quanten-Hall-Effekt (1)
- Quantenfeldtheorie (1)
- Quanteninformation (1)
- Quantenthermodynamik (1)
- Quantenzustand (1)
- QuantiFERON\(^®\)-TB Gold Plus (1)
- Quantum Magnetism (1)
- Quantum many-body systems (1)
- Quantum spin lattices (1)
- Queer (1)
- Quercetin (1)
- Quinolone Amides (1)
- R-type currents (1)
- R57A (1)
- RA-LA-Quotient (1)
- RAKI (1)
- RAMP (1)
- RCA (1)
- RCC (1)
- RCK domain (1)
- RCT (1)
- RIL-seq (1)
- RIM1α (1)
- RNA Labelling (1)
- RNA helicase (1)
- RNA labeling (1)
- RNA metabolism (1)
- RNA modifications (1)
- RNA recognition (1)
- RNA splicing (1)
- RNA transport (1)
- RNA-Protein Interaktom (1)
- RNA-RNA interactions (1)
- RNA-Sequenzierung (1)
- RNA-bindendes Protein (1)
- RNA-binding proteins (1)
- RNA-protein interactome (1)
- RNS-Bindungsproteine (1)
- RNS-Viren (1)
- RPE (1)
- RT-qPCR (1)
- RYGB (1)
- Radfahrerunfall (1)
- Radiation Oncology (1)
- Radikal <Chemie> (1)
- Radikalpaar (1)
- Radiokarbondatierung (1)
- Radiuskorrekturosteotomie (1)
- Radsport (1)
- Random Forest (1)
- Random Matrix Theory (1)
- Random forest (RF) model (1)
- Random-phase-Approximation (1)
- Random-walk simulations (1)
- Ranvier-Schnürring (1)
- Rapamycin (1)
- Rapid Prototyping <Fertigung> (1)
- Raucherberatung (1)
- Raucherentwöhnung (1)
- Rbm8a (1)
- ReNEUAL (1)
- Reaktive Sauerstoffspezies (1)
- Reaktivität (1)
- Real time quantitative PCR (1)
- Realismus (1)
- Receptor Dynamics (1)
- Redoxverhalten (1)
- Reduced density matrix (1)
- Referenzperzentile (1)
- Referenzrahmen (1)
- Reflexionsgeometrie (1)
- Reform der deutschen Krankenversicherung (1)
- Regeneration (1)
- Regenerative Medizin (1)
- Regierung (1)
- Regionale Klimamodelle (1)
- Regionalökonomie (1)
- Regression (1)
- Regulation (1)
- Regulatory T Cells (1)
- Regulierung (1)
- Rehabilitation (1)
- Reichsstudentenführung (1)
- Rekonsolidierung (1)
- Religion (1)
- Religious Practice (1)
- Reläsion (1)
- Remote sensing (RS) (1)
- Renal Cell Carcinoma (1)
- Renormierung (1)
- Rentenreform (1)
- Representation (1)
- Reproducibility challenges (1)
- Reprogrammming (1)
- Repräsentation (1)
- Research Station (1)
- Resektion (1)
- Resilienz (1)
- Resistance mechanism C. auris (1)
- Resistance training (1)
- Resistenz (1)
- Resonance Stabilized Radicals (1)
- Reticular Chemistry (1)
- Retinales Pigmentepithel (1)
- Revenge (1)
- Rezeption (1)
- Rezeptionsforschung (1)
- Rezeptor (1)
- Rezeptor-Tyrosinkinasen (1)
- Rezeptorkonversion (1)
- Rhamno-Prunetea (1)
- Rheology (1)
- Rheumatoid Arthritis (1)
- Rho GTPasw (1)
- Rho-Kinasen (1)
- RhoA (1)
- Ribozym (1)
- Ribozyme (1)
- Riddelliin (1)
- Ringerweiterungsreaktionen (1)
- Risiko (1)
- Risikofaktoren (1)
- Risikostratifizierung (1)
- Robotics (1)
- Robotik (1)
- Rodents (1)
- Rohmaterialanalyse (1)
- Roman (1)
- Rosen-Methode (1)
- Rotary Excitation (1)
- Routing (1)
- Roux-en-Y Gastric Bypass (1)
- Ruthenium Komplexe (1)
- Röntgendetektor (1)
- Röntgenmikroskopie (1)
- Röntgenquelle (1)
- Röntgenquellen (1)
- Röntgenspektroskopie (1)
- Rückenorthese (1)
- S.aureus (1)
- SAH (1)
- SARS-CoV2 (1)
- SCCHN (1)
- SELEX (1)
- SET7 (1)
- SF-36 (1)
- SIB (1)
- SL-Band (1)
- SLAC1 (1)
- SLC-family (1)
- SLC7A11 (1)
- SNF1 (1)
- SOX9 (1)
- SPECT/CT (1)
- SPICT (1)
- STAAB study (1)
- STAAB-Studie (1)
- STAT3 (1)
- STM (1)
- SUMOylation (1)
- SUSTAIN CSX (1)
- SWOT (1)
- Saccharomyces cerevisiae (1)
- Saccotomie (1)
- Saccotomy (1)
- Sachkultur (1)
- Salmonella (1)
- Salmonella Typhimurium (1)
- Salmonella enterica (1)
- Salt Overly Sensitive pathway (1)
- Sarcopenia (1)
- Sarkopenie (1)
- Satellit (1)
- Satellite Earth Observation (1)
- Satellite Remote Sensing (1)
- Satellite glial cell (1)
- Scanning tunneling microscopy (1)
- Schaf (1)
- Schafe (1)
- Scherstress (1)
- Schienung (1)
- Schlaf (1)
- Schlafapnoe (1)
- Schlafbezogene Atmungsstörungen (1)
- Schleimhaut (1)
- Schleimhaut-Ulzera (1)
- Schloss (1)
- Schlussleistenkomplex (1)
- Schlüssel (1)
- Schmerz (1)
- Schmerzforschung (1)
- Schmetterlinge (1)
- Schmuck (1)
- Schockraumbehandlung (1)
- Schockraummanagement (1)
- Schreilaut (1)
- Schroedinger equation (1)
- Schulassistenz (1)
- Schulbegleiter (1)
- Schulbegleitung (1)
- Schulerfolg (1)
- Schulische Inklusion (1)
- Schulische Integration (1)
- Schultereckgelenk (1)
- Schultereckgelenkssprengung (1)
- Schulterinstabilität (1)
- Schusstodesfälle (1)
- Schusswaffe (1)
- Schusswaffenhomizid (1)
- Schusswaffensuizid (1)
- Schutzgebiete (1)
- Schwach koordinierende Anionen (1)
- Schweiz (1)
- Schwelle (1)
- Schwertkärpfling (1)
- Schwindel (1)
- Schädel-Hirn-Trauma (1)
- Schädelchirurgie (1)
- Schädelnaht (1)
- Schädlingsbekämpfung (1)
- Schüler:innen-Befragung (1)
- Score (1)
- Scotogenic Model (1)
- Sechs-Minuten-Gehstrecke (1)
- Second coordination sphere engineering (1)
- Sehen (1)
- Sehnerv (1)
- Sekundärkrankheit (1)
- Selbstkalibrierung (1)
- Selbstmord (1)
- Selbstmordgefährdung (1)
- Selbstorganisation (1)
- Selektivität (1)
- Self-calibration (1)
- Semiconductor (1)
- Senile Makuladegeneration (1)
- Sense of agency (1)
- Sensing-aaS (1)
- Sequence-Structure (1)
- Sequenzdaten (1)
- Serie (1)
- Serotonin (1)
- Serpentinit (1)
- Serumbiomarker (1)
- Setting Control (1)
- Seuchengeschichte (1)
- Sexualität (1)
- Shannon entropy (1)
- Shared Decision Making (1)
- Shear Stress (1)
- Siedlung (1)
- Signaltransduktion (1)
- Silber (1)
- Silica precursor (1)
- Siliciumcarbid (1)
- Siliciumdioxid (1)
- Silicon carbide (1)
- Siliziumcarbid (1)
- Siliziumkarbid (1)
- Single-cell RNA Sequencing (1)
- Single-cell RNA-sequencing (1)
- Single-molecule microscopy (1)
- Singlett Oxygen (1)
- Singulettsauerstoff (1)
- Sinusthrombose (1)
- Sirolimus (1)
- Site-specific RNA labelling (1)
- Skin Tissue Engineering (1)
- Sleep (1)
- Slice Culture (1)
- Slum (1)
- Social Buffering (1)
- Social Circle (1)
- Social Distancing (1)
- Socrates (1)
- Soil-transmitted helminths (1)
- Sol-gel (1)
- Solar cell (1)
- Solar-Cell (1)
- Solid-phase peptide synthesis (1)
- Solubilisation (1)
- Solubility (1)
- South Indian Ocean (1)
- South Korea (1)
- Southern Bavaria (1)
- Soziale Robotik (1)
- Sozialer Ausschluss (1)
- Sozialer Kontakt (1)
- Soziales Umfeld (1)
- Spatiotemporal fusion (1)
- Spechte (1)
- Specialized pro resolving mediators (1)
- Speckle Tracking (1)
- Speiseröhre (1)
- Sphingolipidanaloga (1)
- Sphingolipidderivate (1)
- Sphingolipide (1)
- Sphingolipids (1)
- Sphingolipidstoffwechsel (1)
- Spielkompetenz (1)
- Spin-Bahn-Wechselwirkung (1)
- Spin-Lock (1)
- Spin-Orbit interaction (1)
- Spinal Muscular Atrophy (1)
- Spinal Orthosis (1)
- Spinalganglion (1)
- Spinchemie (1)
- Spinflüssigkeit (1)
- Spo0A (1)
- Sporenbildung (1)
- Sporttraumatologie (1)
- Sportverletzungen (1)
- Sporulation (1)
- Sprachentwicklung (1)
- Spracherwerb (1)
- Sprachgebrauch (1)
- Sprecherwechsel (1)
- Spred-Proteine (1)
- Sprunggelenk (1)
- Spunggelenkendoprothetik (1)
- Squaraine (1)
- Staat (1)
- Stability Maintenance (1)
- Stabilitätsstudien (1)
- Stadtgeographie (1)
- Stammzellen (1)
- Stammzelltransplantation (1)
- Standort (1)
- Standortbedingungen (1)
- Standortfaktor (1)
- Stanfieldit (1)
- Staphylococcus aureus immune response (1)
- Starke Kopplung (1)
- State Estimation (1)
- Stathmin (1)
- Statine (1)
- Status Threat (1)
- Steinartefakte (1)
- Stent (1)
- Sterblichkeit (1)
- Steroide (1)
- Steroidhormon (1)
- Steuerentstrickung (1)
- Steuervermeidung (1)
- Stevia rebaudiana (1)
- Sticker, Georg (1)
- Stickstofffixierung (1)
- Stickstoffmonoxid (1)
- Stimme (1)
- Stimmgesundheit (1)
- Stimmprävention (1)
- Stimulationsversuche (1)
- Stochastische Matrix (1)
- Stomata (1)
- Strahlentherapie bei Morbus Hodgkin (1)
- Straining (1)
- Strategic Emerging Industries (1)
- Street children (1)
- Streptozocin (1)
- Streptozotocin (1)
- Stroke Unit (1)
- Strongyloides (1)
- Strongyloides stercoralis (1)
- Structure-from-Motion (1)
- Struktur (1)
- Struktur-Aktivitäts-Beziehung (1)
- Strukturen (1)
- Strukturierung (1)
- Strumpellin (1)
- Studentengeschichte (1)
- Studentenverbindung (1)
- Students History (1)
- Su-Schrieffer-Heeger chain (1)
- Su-Schrieffer-Heeger-Kette (1)
- Subarachnoidalblutung (1)
- Subjektivität (1)
- Substanzverlust (1)
- Suizidalität (1)
- Sulfatkonjugate (1)
- Sulforaphan (1)
- Super-Resolution Microscopy (1)
- Supercap (1)
- Superkondensator (1)
- Supply Chain Design (1)
- Supply Chain Management (1)
- Support Vector Regression (1)
- Survival (1)
- Sustainable Agriculture (1)
- Sustainable Development (1)
- Symplektische Geometrie (1)
- Synaptische Transmission (1)
- Synaptische Vesikel (1)
- Synthetic Aperture RADAR (1)
- Synthetic RS data (1)
- Synthetische Apertur (1)
- Syphilis (1)
- Syrien (1)
- Systematik (1)
- Systematische Übersichtsarbeit (1)
- Säugling (1)
- Südalpiner Feuerstein (1)
- Südbayern (1)
- Südkorea (1)
- T Helper Cell (1)
- T Lymphocyte (1)
- T and NK development (1)
- T antigen (1)
- T cell (1)
- T-Lymphozyten (1)
- T-Track\(^®\) TB (1)
- T-Zell-Plastizität (1)
- T-Zellmigration (1)
- T-cell engager (1)
- T-cell lymphoma (1)
- T-shaped π–π stacking (1)
- T1rho (1)
- T1ρ (1)
- TAC (1)
- TB (1)
- TDM (1)
- TETC (1)
- TFCC (1)
- TKA (1)
- TLR3 (1)
- TMEM119 (1)
- TNAP (1)
- TNF (1)
- TNFR1 (1)
- TNFR2 (1)
- TNFα (1)
- TPACK (1)
- TRAF2 (1)
- TRRAP (1)
- TTL validation of data consistency (1)
- Tagesrhythmus (1)
- Takeover request (1)
- Talententwicklung (1)
- Talentförderung (1)
- Tamoxifen (1)
- Tandem-Peptid (1)
- Taraxacum cimae-gallinae spec. nov. (1)
- Taraxacum sect. Borealia (1)
- Targeted drug delivery (1)
- Targeted therapy (1)
- Taxol (1)
- Teaching model (1)
- Temporal binding (1)
- Temporal predictability (1)
- Temporäre Hemiepiphyseodese (1)
- Testinstrument (1)
- Tetracenderivate (1)
- Tetracene derivatives (1)
- Text analysis (1)
- Textanalyse (1)
- Th17-Zelle (1)
- Theologie (1)
- Theoretical Chemistry (1)
- Theorie (1)
- Theory of Mind (1)
- Therapeutisches Drug Monitoring (1)
- Therapie (1)
- Therapieresistenz (1)
- Therapieziel (1)
- Thermal equilibrium (1)
- Thermalisierung (1)
- Thermogenesis (1)
- Thesen (1)
- Thigmotaxis (1)
- Thrombose (1)
- Thrombosis (1)
- Thrombozyten (1)
- Thrombozytenaktivierung (1)
- Thyreoidektomie (1)
- Ti plasmids (1)
- Tian Rucheng (1)
- Tiermodell (1)
- Tierversuch (1)
- Tierversuche (1)
- Tissue staining (1)
- Titan (1)
- Titration (1)
- Tjap1 (1)
- Tolane-Modified Fluorescent Nucleosides (1)
- Toll-like receptor signaling (1)
- Tomografie (1)
- Topolectrics (1)
- Topological Pumping (1)
- Topological metamaterial (1)
- Topological semimetals (1)
- Topological superconductivity (1)
- Topologische Halbmetalle (1)
- Topologische Phase (1)
- Topologische Supraleitung (1)
- Tourismus (1)
- Training Intensity Distribution (1)
- Trainingsintensität (1)
- Trainingsteuerung (1)
- Transfer (1)
- Transkription <Genetik> (1)
- Transkriptionelle Regulierung (1)
- Transkriptionsfaktor (1)
- Transnationalismus (1)
- Transplantatabstoßung (1)
- Transposon (1)
- Transsexualität (1)
- Trauma (1)
- Traumatic neuropathy (1)
- Traumatologie (1)
- Traveling culture (1)
- Treatment Time (1)
- Treatment switch in fabry disease (1)
- Treg (1)
- Trem2 (1)
- Trepanation (1)
- Triangular lattice (1)
- Triangulärer fibrokartilaginärer Komplex (1)
- Triarylborane (1)
- Tricalciumphosphatkeramik (1)
- Tripper (1)
- TrkB (1)
- TruD (1)
- Trypanosoma (1)
- Trypanosoma brucei (1)
- Trypanosomiase (1)
- Trypanosomiasis (1)
- Tumor Treating Fields (1)
- Tumor Treating Fields (TTFields) (1)
- Tumor-Treating Fields (TTFields) (1)
- Tumorimmunumgebung (1)
- Twitter (1)
- Tür (1)
- UBA6 (1)
- UBE2Z (1)
- UNESCO designations (1)
- Ubiquitylation (1)
- Ultrafast spectroscopy (1)
- Ultrakurzzeitspektroskopie (1)
- Ultraschallkardiografie (1)
- Ultraschallprüfung (1)
- Umweltanthropologie (1)
- Umweltpolitik / Kompensation (1)
- Uncanny Valley of Mind (1)
- Unconventional/Topological superconductivity (1)
- Underwater Mapping (1)
- Underwater Scanning (1)
- Unfall (1)
- United States (1)
- Universal Two-Child Policy (1)
- Universitätsgeschichte (1)
- Unterarmbruch (1)
- Unterarmfraktur (1)
- Unterart (1)
- Unterbrechungen (1)
- Unterernährung (1)
- Unterricht (1)
- Unterrichtsvorschläge (1)
- Ureaplasma parvum (1)
- Ureterimplantation (1)
- VAS (1)
- VE-Cadherin (1)
- VE-PTP (1)
- VLA-1 (1)
- Vaccine education (1)
- Vaccinia (1)
- Vaccinia-virus (1)
- Validierungsstudie (1)
- Vapreda (1)
- Vascular closure devices (1)
- Vaskularisation (1)
- Vasopressin (1)
- Velocity-Map-Imaging (1)
- Vena cava inferior (1)
- Venezuela (1)
- Venus (1)
- Verband Alter Corpsstudenten (1)
- Vereinigte Staaten (1)
- Verletzbarkeit (1)
- Vernacular poety (1)
- Vernacular story (1)
- Vernetzung <Chemie> (1)
- Vero E6 (1)
- Verordnungsverhalten (1)
- Verschwörungstheorie (1)
- Versorgungsplanung (1)
- Versorgungswünsche (1)
- Verwaltung (1)
- Verwaltungsakt (1)
- Verwaltungsautomation (1)
- Verwaltungsautomatisierung (1)
- Verwaltungsrecht (1)
- Verwaltungsverfahren (1)
- Verwaltungsverfahrensrecht (1)
- Verwundbarkeit (1)
- Verwundbarkeit der Menschenrechte (1)
- Veröffentlichung (1)
- Vestibulärer-Aquädukt-Score (1)
- Viabilität (1)
- Vicia faba (L.) (1)
- Vickers-Band (1)
- Vincristin (1)
- Virostatikum (1)
- Virus infection (1)
- Visualized Kathará (1)
- Visuelle Orientierung (1)
- Visuelle Wahrnehmung (1)
- Vitamin D (1)
- Vitamin D-Rezeptor (1)
- Vitamin D3 (1)
- Vitamin K-abhängige Gerinnungsfaktoren II, VII, IX, X (1)
- Vitis vinifera (1)
- Vokalisationen (1)
- Vokant (1)
- Volatile Organic Compound (VOC) (1)
- Volumentomografie (1)
- Vomiting (1)
- Vorderes Kreuzband (1)
- Vorherbestimmung (1)
- Vorhersage (1)
- Vorklinikausbildung (1)
- Vorsorgevollmacht (1)
- Vulneranz (1)
- WASH complex (1)
- WaSiM-ETH (1)
- Wahrgenommener Reichtum (1)
- Wahrnehmung (1)
- Waiting Impulsivity (1)
- Wald (1)
- Wallace, Michele (1)
- Wandgräbchenbau (1)
- Wasseroxidation (1)
- Water Oxidation (1)
- Weakly Coordinating Anions (1)
- Weakly chromophore impurities (1)
- Web services (1)
- Wechsler intelligence scale (WISC-IV) (1)
- Weiblicher Nachwuchsfußball (1)
- Weimarer Republik (1)
- Weiterbildung (1)
- Wertfreiheit (1)
- Werturteilsfreiheit (1)
- West African refugee crisis (1)
- West Gondwana (1)
- West Lake (1)
- Western Europe (1)
- Westjordanland (1)
- Weyl Halbmetalle (1)
- Weyl semimetals (1)
- WhatsApp (1)
- Whole Body Vibration (1)
- Widerstand (1)
- Wilde Honigbienen (1)
- Wildpflanzen (1)
- Wilhelm Raabe (1)
- Wiliams, Raymond (1)
- Willams, Raymond (1)
- Winter wheat (1)
- Wirkstoff (1)
- Wirkstoffdesign (1)
- Wirkstoffentwicklung (1)
- Wirkungsanalyse (1)
- Wirtschaftsentwicklung (1)
- Wirtschaftswachstum (1)
- Wissenschaft (1)
- Wissenschaftliche Beobachtung (1)
- Wissenschaftsgeschichte (1)
- Wissenserwerb (1)
- Wissensstand (1)
- Wnt (1)
- Wnt-Signalweg (1)
- Wnt-pathway (1)
- Wohnformen der Armut (1)
- Wolle (1)
- Wundheilung (1)
- Wundsekret (1)
- Wurzelkanalrevision (1)
- X-Chromosom (1)
- X-Inaktivierung (1)
- X-Ray (1)
- X-ray computed (1)
- XAI (1)
- XAI and explainable artificial intelligence (1)
- XLH (1)
- XMCD (1)
- Xanomeline (1)
- Xinjiang (1)
- YAP (1)
- YAP5SA (1)
- YouTube (1)
- Ypk1 (1)
- Yu-Shiba-Rusinov-Zustände (1)
- ZIP (1)
- Zahnarztpraxis (1)
- Zahnfleischentzündung (1)
- Zahnmedizin (1)
- Zangenbiopsie (1)
- Zebrafish (1)
- Zeitreihe (1)
- Zelldifferenzierung (1)
- Zellkern (1)
- Zelllinie (1)
- Zellteilung (Zytokinese) (1)
- Zellvermehrung (1)
- Zhang Dai (1)
- Zielorientierung (1)
- Zinc phthalocyanine (1)
- Zinkphthalocyanin (1)
- Zins (1)
- Zustandsdichte (1)
- Zustandserkennung (1)
- Zweidimensionale konforme Feldtheorie (1)
- Zweidimensionales Material (1)
- Zwergfadenwurm (1)
- Zytotoxizität (1)
- [\(^{68}\)]KISS1-54 (1)
- \(^1\)H-NMR spectroscopy (1)
- \(^{11}\)C-Methionin (1)
- \(^{18}\)F-Fluordesoxyglucose (1)
- abdominal imaging (1)
- abiotic stress (1)
- academia (1)
- academic domains (1)
- acceptance-based strategies (1)
- access site complications (1)
- accuracy (1)
- acid value (1)
- action control (1)
- action prepotency (1)
- activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL) (1)
- activating transcription factor 4 (ATF4) (1)
- active TB (1)
- active galactic nuclei (1)
- actors (1)
- acute brain slices (1)
- acute esophageal necrosis (1)
- acute kidney injury (1)
- adaptive intervention competence (1)
- addiction (1)
- additive manufacturing (1)
- adipocytes (1)
- adiponectin (1)
- adipose tissue (1)
- adipose-derived stromal cells (1)
- adjoint and coadjoint representations (1)
- adjustment (1)
- adjuvant therapy (1)
- administración digital (1)
- adrenal cancer (1)
- adrenal imaging (1)
- adrenal incidentaloma (1)
- adrenocortical adenoma (1)
- adrenocortical carcinoma (ACC) (1)
- adsorption (1)
- adverse drug reaction (1)
- adverse effects (1)
- aesthetic results (1)
- affinity (1)
- affluence (1)
- age (1)
- age and gender analysis (1)
- age determination by skeleton (1)
- age distribution (1)
- ageing (1)
- aggression (1)
- agonism (1)
- agonistic antibodies (1)
- agricultural landscape (1)
- airway management (1)
- akademische Domänen (1)
- akute Niereninsuffizienz (1)
- algebraic degree (1)
- algorithms (1)
- alkene-alkyne [2+2] photocycloaddition (1)
- alkylation damage (1)
- allogeneic stem cell transplantation (1)
- allogenic stem cell transplantation (1)
- allografts (1)
- alpha-IIb beta-3 (1)
- alpine Taraxaca (1)
- alternating management (1)
- alternative pig farming (1)
- alveolar bone loss (1)
- alveoläre Hypoventilation (1)
- amber light (1)
- amino acid restriction (1)
- anaemia (1)
- anaerobe (1)
- anatomy (1)
- anchoring (1)
- ancistrocladinium A (1)
- anesthesia (1)
- anesthesiology (1)
- aneurysmatisch (1)
- angle-resolved photoelectron spectroscopy (1)
- animal models (1)
- animal physiology (1)
- animal studies (1)
- anion channels (1)
- anisotropy (1)
- ankle (1)
- annotation (1)
- annual report (1)
- antegrade puncture (1)
- antenna phase center calibration (1)
- anterior insula (1)
- anthropomorphism (1)
- anti-GFAP (1)
- anti-inflammatory cytokines (1)
- anti-thrombotic therapies (1)
- anti-tumor agents (1)
- antibakteriell (1)
- antibody (1)
- anticoagulation (1)
- antidepressants (1)
- antifungal drug (1)
- antigen-presenting cells (1)
- antiinflammatorisch (1)
- antimicrobial immunity (1)
- antimicrobial resistance (1)
- antimicrobial responses (1)
- antioxidant (1)
- antivirale Substanzen (1)
- antivirals (1)
- anxious depression (1)
- aorta (1)
- aortic valve stenosis (1)
- apexification (1)
- appendicitis (1)
- approach versus withdrawal (1)
- aquaporins (1)
- aqueous humor outflow (1)
- arabidopsis thaliana (1)
- aromaticity (1)
- arousal inhibition (1)
- arrhythmia (1)
- arthrography (1)
- arthroscopic simulator training (1)
- artifical inteligence (1)
- artificial human skin (1)
- artificial photosynthesis (1)
- assembloid (1)
- asymptotic preserving (1)
- ataxia teleagiectasia mutated (ATM) (1)
- atopic diseases (1)
- attention deficit (1)
- attentional processes (1)
- auctions (1)
- autoantibodies (1)
- autobiographical memory (1)
- autoimmune nodopathy (1)
- autoimmune skin blistering disease (1)
- autonomic (1)
- autonomous cortisol secretion (1)
- autonomy (1)
- autophosphorylation of ERK1/2 (1)
- availability (1)
- axial vascularization (1)
- axons (1)
- azapeptide nitriles (1)
- azido-ceramides (1)
- azobenzenes (1)
- background knowledge (1)
- bacterial community (1)
- bacterial migration (1)
- bacterial virulence (1)
- balance (1)
- bariatric surgery (1)
- basal ganglia (1)
- baseline detection (1)
- battery depletion (1)
- beads (1)
- bedingte elektrische Stimulation (1)
- bee diseases (1)
- bee-lining (1)
- beech (1)
- bees (1)
- behaviometric (1)
- behavioral conditioning (1)
- bent pointing (1)
- benzimidazole (1)
- beta cell (1)
- beta power (1)
- beta-Catenin (1)
- beta-catenin (1)
- bilateral motor network (1)
- biliäre Stenose (1)
- biliäre Striktur (1)
- bioceramic (1)
- biocompatible materials (1)
- biodiversity conservation (1)
- biodosimetry (1)
- bioelectronics (1)
- biofabrication (1)
- bioink (1)
- bioinorganic (1)
- biological scaffold (1)
- biology (1)
- biomedical engineering (1)
- bioorthogonal SAM analogue ProSeDMA (1)
- bioorthogonale Markierung (1)
- biophysics (1)
- biostratigraphy (1)
- biosynthetic glycosylation (1)
- bipartite metabolism (1)
- bipolar disorder (1)
- bit (1)
- bitopic hybrid ligands (1)
- bitopic ligands (1)
- bitter taste (1)
- blended learning (1)
- blockchain anchoring (1)
- blockchain in healthcare (1)
- blockchain in the pharmaceutical industry (1)
- blockchain interoperability (1)
- blood CSF barrier (1)
- blood brain barrier (1)
- blood platelets (1)
- blood vessel (1)
- body axis (1)
- body size (1)
- bond activation (1)
- bond theory (1)
- bone adhesive (1)
- bone cement (1)
- bone conduction implant (1)
- bone glue (1)
- bone imaging (1)
- bone metabolism (1)
- bone metastases (1)
- bone morphogenetic protein 9 (BMP9) (1)
- bone morphogenetic proteins (1)
- bone regeneration (1)
- bone remineralization (1)
- bone replacement material (1)
- boraselenone (1)
- borirane (1)
- botulinum neurotoxin (1)
- boundary spanning (1)
- brain endothelium (1)
- brain signal complexity (1)
- brain-computer interfaces (BCI) (1)
- branched-chain amino acids (1)
- breast cancer imaging (1)
- breed predisposition (1)
- bridging (1)
- building with foundations trenches (1)
- built environment (1)
- bullous pemphigoid (1)
- bullying (1)
- burnout (1)
- business process anagement (1)
- butyrate (1)
- bycicle accident (1)
- c-kit (1)
- cAAC (1)
- cAMP (1)
- cadaver multiorgan preservation (1)
- calcium activity (1)
- calcium channels (1)
- calcium cycling (1)
- calcium phosphate (1)
- calibration (1)
- caloric restriction (1)
- calorimetry (1)
- calprotectin (1)
- camera orientation (1)
- cancellous bone (1)
- cancer imaging (1)
- cancer immune cell therapy (1)
- cancer immunotherapy (1)
- candidate gene (1)
- canine (1)
- canola (1)
- canopy height (1)
- capillary electrophoresis (1)
- carbon dioxide (CO2) (1)
- carbon emissions (1)
- carborane (1)
- carcinoma (1)
- cardiac arrest (1)
- cardiac hypertrophy (1)
- cardiac implantable electronic devices (CIED) (1)
- cardiac resynchronization therapy (CRT) (1)
- cardiac surgery (1)
- cardinality (1)
- cardiology (1)
- cardioprotective potential (1)
- cardiovascular MRI (1)
- cardiovascular diseases (1)
- cardiovascular events (1)
- cardiovascular risk factors (1)
- caregiver (1)
- caregiver burden (1)
- cartilage regeneration (1)
- cartilage surgery (1)
- caste system (1)
- catalase (1)
- catholicism (1)
- causality (1)
- cell (1)
- cell cycle (1)
- cell death (1)
- cell differentiation patterns (1)
- cell line specificity pyridyl indole carboxylates (1)
- cell line-specificity (1)
- cell sate variability (1)
- cell velocimetry (1)
- cell vitality (1)
- cellmigration (1)
- cellular physiology (1)
- cellular signalling networks (1)
- cellular stress response (1)
- central bank information (1)
- cephalometry (1)
- ceramides (1)
- cerebEND (1)
- cerebEND Zellkultur (1)
- cerebellum (1)
- cerebral inflammation (1)
- cerebraler Blutfluss (1)
- cerebrospinal fluid (1)
- cerebrovascular disorders (1)
- cervical dystonia (1)
- change vector analysis (1)
- charge transfer (1)
- charged aerosol detector (1)
- chemical bonding (1)
- chemical ecology (1)
- chemical glycosylation (1)
- chemical libraries (1)
- chemokine receptor (1)
- chiasma antebrachii (1)
- child and adolescent psychiatry (1)
- child development (1)
- children (1)
- chiral (1)
- chlorantraniliprole (1)
- chlorite (1)
- chondral defect (1)
- chondrogene Differenzierung (1)
- chondrogenesis (1)
- chondrogenic hypertrophy (1)
- chromatin (1)
- chromatin accessibility (1)
- chronic IBD model (1)
- chronic heart failure (1)
- chronic kidney disease (1)
- cine loop (1)
- circadian rhythm (1)
- circular dichroism (1)
- circulating (1)
- circulation types (1)
- circum-Arctic (1)
- cisplatin (1)
- classification (1)
- claudin 1 (1)
- climate (1)
- climate model (1)
- climate policy (1)
- climate resilience (1)
- climate‐smart pest management (1)
- clinical decision support (1)
- clinical measurement in health technology (1)
- clinical outcome (1)
- clinical skills (1)
- clinical study (1)
- clinical systems (1)
- closing of chromatin (1)
- closo-Borane (1)
- cluster analysis (1)
- coastal erosion (1)
- cochlear duct length (1)
- cochlear nucleus (1)
- cocoa mapping (1)
- cognitive ability (1)
- cognitive bias (1)
- cognitive decline (1)
- cognitive deficits (1)
- cognitive load (1)
- cognitive neuroscience (1)
- cognitive profile (1)
- cognitive remediation (1)
- coherence (1)
- collagen (1)
- colllagen (1)
- collybistin (1)
- color (1)
- colorectal cancer (1)
- combination (1)
- commensal bacteria (1)
- communication models (1)
- communication networks (1)
- communication skills (1)
- comparability (1)
- comparison exercise (1)
- complementary medicine (1)
- complex‐valued machine learning (1)
- complications (1)
- computational chemistry (1)
- computational neural networks (1)
- computed tomography angiography (CTA) (1)
- computer modelling (1)
- computer navigation (1)
- computer performance evaluation (1)
- computer vision (1)
- computer-aided (1)
- conditionality (1)
- cone-beam computed tomography (1)
- confocal Raman imaging (1)
- conformational activation (1)
- consentimiento electrónico (1)
- conservation biology (1)
- contactin (1)
- content-based image retrieval (1)
- contingent electrical stimulation (1)
- continuous extracorporeal femoral perfusion model (1)
- contrast effect (1)
- control group (1)
- controllability (1)
- conventional imaging (1)
- convolution kernel (1)
- cooperation (1)
- coordination chemistry (1)
- coping (1)
- cord blood (1)
- coronar suture (1)
- coronary angiography (1)
- coronary artery disease (1)
- coronary heart disease (1)
- coronavirus (1)
- coronavirus disease 2019 (1)
- cortico-striatal synapse (1)
- corticoid (1)
- covalent inhibitors (1)
- covariance and correlation (1)
- covert retrieval (1)
- craniometric (1)
- cranioplasty (1)
- craniosynostosis (1)
- creativity (1)
- critical care (1)
- crop modeling (1)
- crop models (1)
- crop rotation (1)
- cross-sectional imaging (1)
- cryo-EM (1)
- cryo-ET (1)
- crystal growth (1)
- crystallographic analyses (1)
- cue availability (1)
- cue exposure therapy (1)
- cue reactivity (1)
- cultivated plants (1)
- cultural diversity (1)
- cultural heritage (1)
- curriculum development (1)
- cut and sew technique (1)
- cutaneous lymphomas (1)
- cuticular hydrocarbon (1)
- cutting (1)
- cyclic alkyl(amino)carbenes (1)
- cyclization reactions (1)
- cyclodextrins (1)
- cyclosporin A (1)
- cytochrome P450s (1)
- cytosine base editor (CBE) toolbox (1)
- cytoskeleton (1)
- cytosolic pH (1)
- cytotopes (1)
- cytotoxic T cells (1)
- cytotoxicity (1)
- dSPN (1)
- damage control orthopedics (1)
- data analysis (1)
- data augmentation (1)
- data display (1)
- data storage (1)
- data warehouse (1)
- dataset (1)
- ddPCR (1)
- de Casteljau Algorithm (1)
- de novo sequenced genomes (1)
- deafness (1)
- decafluoroazobezene (1)
- decay (1)
- deciduous tooth loss (1)
- decision support system (1)
- defensive states (1)
- definite clause grammars (1)
- degradation (1)
- delay constrained (1)
- delay of therapy (1)
- deliberation (1)
- dendritic cells (1)
- dens invaginatus (1)
- density functional calculations (1)
- density gradient centrifugation (1)
- dental education (1)
- depressive disorder (1)
- derivative (1)
- dermal fibroblasts (1)
- desiccation (1)
- design (1)
- design of experiments (1)
- desmosomal mutations (1)
- determination key (1)
- developmental biology (1)
- developmental differentiation (1)
- dexamethasone (1)
- diabetes mellitus (1)
- diagnostic accuracy (1)
- diagnostic correctness (1)
- diagnostic markers (1)
- diagnostics (1)
- dialysis adequacy (1)
- dicarboximide (1)
- dicoordinate borylene (1)
- diet (1)
- difference-in-differences (1)
- differential RNA-seq (1)
- differential Shannon entropy (1)
- differential centrifugation (1)
- differential expression (1)
- differential graded modules (1)
- differentiated thyroid cancer (1)
- digit (1)
- digital Health (1)
- digital age (1)
- digital medicine (1)
- digital subtraction angiography (DSA) (1)
- digital tools (1)
- digital twin (1)
- digitalization (1)
- dimethyl fumarate (1)
- direct pathway (1)
- disability (1)
- discourses of gender and ethnicity (1)
- disease score (1)
- disease severity (1)
- diseases (1)
- disengagement (1)
- dishonest responding (1)
- dishonesty (1)
- disjoint multi-paths (1)
- disorder of immunity (1)
- distance learning (1)
- distress (1)
- distribution (1)
- dog (1)
- door (1)
- dopaminergic cells (1)
- dormancy (1)
- dosimetry (1)
- drift-diffusion model (1)
- drift-diffusion modeling (1)
- drillability (1)
- driving pressure (1)
- drought stress indicators (1)
- drug delivery (1)
- drug repurposing (1)
- drug resistance (1)
- drug safety (1)
- dual action benefits (1)
- dual targeting (1)
- dual tasking (1)
- dual-energy CT (1)
- dual-source CT (1)
- dualsteric ligands (1)
- dust microbiomes (1)
- dynamic protein-protein interactions (1)
- dynamics (1)
- dystonia (1)
- e-Government (1)
- e-Learning (1)
- eGFR (1)
- early breast cancer (1)
- early detection (1)
- echinococcosis (1)
- echinocytes (1)
- echocardiography (1)
- eco health (1)
- ecology (1)
- ecosystem function (1)
- effector Treg (eTreg) (1)
- effector cells (1)
- elections (1)
- electrical and electronic engineering (1)
- electrocution (1)
- electroencephalography (EEG) (1)
- electromyography (1)
- electron tomography (1)
- electronic health records (1)
- electronic properties and materials (1)
- electron–nuclear dynamics (1)
- electrophysiology (1)
- electroporation (1)
- elektrochemische Fluorierung (1)
- elite athlete (1)
- elite sport (1)
- embryonale Stammzelle (1)
- emergency information (1)
- emotion (1)
- emotion measurement (1)
- emotional shifts (1)
- emotions (1)
- emphysema (1)
- emulation (1)
- enantiomers (1)
- end-stage kidney disease (1)
- endoglin (1)
- endoradiotherapy (1)
- endoscopic instruments (1)
- endoscopic intervention (1)
- endosomal trafficking (1)
- endovaskuläre Therapie (1)
- endpoint geodesics (1)
- endurance (1)
- energy efficiency (1)
- enhancers (1)
- enteroids (1)
- entomology (1)
- environmental health (1)
- environmental impact (1)
- ephedrine (1)
- epidemic history (1)
- epidemiological analysis (1)
- epidemiology (1)
- epigenetic modification (1)
- epigenetics (1)
- episodic binding (1)
- epitaxial structures (1)
- epithelial barrier (1)
- epitope mapping (1)
- equilibrium real interest rate (1)
- equivocation (1)
- error (1)
- error processing (1)
- error-transfer (1)
- ester value (1)
- eudaimonia (1)
- euglena (1)
- euglenids (1)
- europäisches Verwaltungsrecht (1)
- evidence synthesis (1)
- evidence-based policy (1)
- evidence-based practice (1)
- evolutionary developmental biology (1)
- evolutionary genetics (1)
- exchange rate dynamics (1)
- exciton (1)
- excitonic chirality (1)
- exemplarity (1)
- exercise science (1)
- exhaustion (1)
- experience (1)
- experimental models of disease (1)
- experimental stroke (1)
- explainability of machine learning (1)
- exponent pairs (1)
- exponential growth (1)
- exposure therapy (1)
- expression (1)
- extended cognition (1)
- extended reality (1)
- extinction (1)
- extracellular (1)
- extracellular domain (1)
- extracellular matrix (1)
- extracorporeal membrane oxygenation (1)
- eye contact (1)
- eye movement disorders (1)
- fMRI time series (1)
- fNIRS (1)
- fabry disease (1)
- fatigue (1)
- fatty acids (1)
- fear generalization (1)
- feasibility (1)
- feather grass (1)
- feature analysis (1)
- feature matching (1)
- feature selection (1)
- feature tracking (1)
- fecal short-chain fatty acids (1)
- federated learning (1)
- feeding (1)
- femoral access (1)
- femoral arteries (1)
- femoral fracture (1)
- feral bees (1)
- fiber intake (1)
- fibrin (1)
- fibrosis (1)
- fibula (1)
- filamentous Salmonella Typhimurium (1)
- film analysis (1)
- finger-tapping task (FTT) (1)
- firearm homicides (1)
- firearm suicides (1)
- fitness trackers (1)
- fixation (1)
- flexor digitorum superficialis (1)
- flexor tendon (1)
- flowering plants (1)
- flowers (1)
- fluorescence (1)
- fluorescence lifetime imaging microscopy (1)
- fluorescence polarization (1)
- fluorescence resonance energy transfer (1)
- fluorescence resonance energy transfer (FRET) (1)
- fluorescent probe (1)
- fluoroscopy (1)
- fmri activity (1)
- focus of infection (1)
- fog computing (1)
- folded macrocyles (1)
- follicular lymphoma (1)
- food cultures (1)
- foot and ankle procedures (1)
- forager (1)
- force (1)
- fordisc (1)
- forensic anthropology (1)
- forest (1)
- forest ecology (1)
- forest hydrology (1)
- forest landscape (1)
- forest structure Germany (1)
- formalin (1)
- formulation development (1)
- fostamatinib (1)
- foxtapeworm (1)
- fpVCT (1)
- fracture (1)
- fracture incidence (1)
- fragility fractures (1)
- frailty (1)
- free jet (1)
- free light chains (1)
- frontal bone (1)
- fully convolutional neural networks (1)
- functional connectivity (1)
- functional electrical stimulation (1)
- functional neuroimaging (1)
- functional resting-state connectivity (1)
- funktionelle Kernspintomographie (1)
- funktionelle MRT (1)
- funktionelle Magnetresonanztomographie (1)
- funktionelle Resting-State Konnektivität (1)
- fused boracycles (1)
- fused deposition modeling (1)
- fusion (1)
- future energy grid exploration (1)
- gadoliniumhaltiges Kontrastmittel (1)
- gait-phase prediction (1)
- game layers (1)
- gammadelta T cells (1)
- gastroenterology (1)
- gastrointestinal (1)
- gender (1)
- gene (1)
- gene ADGRL3 (1)
- gene editing (1)
- gene expression heterogeneity (1)
- gene expression noise (1)
- general circulation model (1)
- general cognitive ability (1)
- general practice (1)
- genetic engineering (1)
- genetic modification (1)
- genetic screen (1)
- genotoxicity (1)
- genotypes (1)
- geographically weighted regression (1)
- geometric morphometrics (1)
- geriatric cancer patient (1)
- germanium (1)
- glial fibrillary acidic protein (1)
- global (action-inherent) (1)
- global IPX network (1)
- global longitudinal strain (1)
- globus pallidus (1)
- glutathione peroxidase (1)
- glycine uptake (1)
- glycoengineering (1)
- glycogen synthase kinase 3 (1)
- glycosylation (1)
- good clinical practice (1)
- gp130 (1)
- graft (1)
- gram-negative bacteria (1)
- grasshopper (1)
- gravity (1)
- grazing (1)
- ground plans (1)
- ground-plan (1)
- group 10 element (1)
- group-based communication (1)
- growth cone (1)
- growth models (1)
- guanylyl cyclase (1)
- guideline-directed medical therapy (1)
- gustatory receptors (Grs) (1)
- gut barrier (1)
- haircoat (1)
- half-Heusler (1)
- haloacid dehalogenase phosphatase (1)
- halogenation (1)
- hand dominance (1)
- hardware-in-the-loop simulation (1)
- hardware-in-the-loop streaming system (1)
- hausärztlich (1)
- head and neck cancer (1)
- health care (1)
- health sciences (1)
- health-care workers (1)
- health-related quality of life (1)
- healthcare assistants (1)
- hearing aids (1)
- heart (1)
- heart rate variability (1)
- heart valve bypass (1)
- heat transfer (1)
- helical edge states (1)
- hematoma (1)
- hematopoietic stem cells (1)
- hemodialysis (1)
- hemoglobin jet (1)
- hemolymph lipids (1)
- heparin binding sites (1)
- herpes virus (1)
- heuristics (1)
- high contrast (1)
- high throughput screening (1)
- high tibial osteotomy (1)
- high-frequency identification (1)
- higher plants (1)
- histopathology (1)
- historical document analysis (1)
- historical images (1)
- historical psychology (1)
- history of psychology (1)
- hit ratio analysis and simulation (1)
- hochauflösende Fluoreszenzmikroskopie (1)
- home isolation (1)
- homeostasis (1)
- homogeneous catalysis (1)
- honey bee density (1)
- honeybee taste perception (1)
- honeycomb lattice (1)
- hospital (1)
- hospital data (1)
- host-guest chemistry (1)
- human (1)
- human African trypanosomiasis (1)
- human brain microvascular endothelial cells (HBMVEC) (1)
- human cells (1)
- human cytomegalovirus (HCMV) (1)
- human factors (1)
- human induced pluripotent stem cells (1)
- human induced pluripotent stem cells (hiPSC) (1)
- human learning (1)
- human nutrition (1)
- human startle disease (1)
- human tumor cell lines (1)
- humanized hemato-lymphoid mice (1)
- humanized mice (1)
- human–computer interaction (1)
- hyaluronic acid (1)
- hybrid ligands (1)
- hybrid materials (1)
- hydrides (1)
- hydrogel (1)
- hymenoptera (1)
- hyperbolic partial differential equations (1)
- hyperpolarization (1)
- hypertension (1)
- hypoxia (1)
- hämatopoetische Stammzelltransplantation (1)
- iPSC (induced pluripotent stem cells) (1)
- iliac crest transfer (1)
- illness experience (1)
- immature tooth (1)
- immaturity (1)
- immediate early genes (1)
- immune cell infiltration (1)
- immune evasion (1)
- immune infiltration (1)
- immune response (1)
- immunofluorescence (1)
- immunogenetics (1)
- immunoglobulin rearrangement (1)
- immunoglobulin repertoire (1)
- immunomodulation (1)
- immunosurveillance (1)
- implantable cardioverter defibrillator (ICD) (1)
- implementation framework (1)
- implications of wealth (1)
- imposition (1)
- impression formation (1)
- in silico analysis (1)
- in vitro (1)
- in vitro and in vivo thrombus formation (1)
- in vitro culture (1)
- in vitro dissolution methods (1)
- in vitro dissolution testing (1)
- in vitro study (1)
- in vitro/in vivo Korrelation (1)
- in vitro/in vivo correlation (1)
- in vivo dissolution (1)
- inappropriate medication (1)
- inbound medical tourism (1)
- inclusive education (1)
- income wealth threshold estimations (1)
- individual drug responses (1)
- individual mind state (1)
- individueller Bolus (1)
- indoxacarb (1)
- induced pluripotent stem cells (1)
- inebilizumab (1)
- inertial measurement units (1)
- infant skull (1)
- infection detection (1)
- inferior frontal gyrus (1)
- inflammatory cell model (1)
- inflammatory disease (1)
- inflammatory neuropathy (1)
- inflammatory pain (1)
- influenza A virus (1)
- influenza vaccination (1)
- infodemic (1)
- informal education (1)
- information extraction (1)
- information strategies (1)
- information theory entropy (1)
- inherent chirality (1)
- inhibition failures (1)
- inhibitor (1)
- inhibitory postsynapse (1)
- innate immunity training (1)
- insect conservation (1)
- insecticide (1)
- instrument design (1)
- insulin receptor (1)
- integral graph (1)
- integrated stress response (1)
- intellectual disability (1)
- intellektuelle Beeinträchtigung (1)
- intelligence (1)
- intelligent voice assistant (1)
- intensity analysis (1)
- intensity distribution (1)
- intensity of attention (1)
- interactivity (1)
- intercultural pedagogy (1)
- interference pattern (1)
- interferometry (1)
- interior structure (1)
- internal globus pallidus (1)
- internal medicine (1)
- international trade (1)
- intervention strategies (1)
- interview study (1)
- intestinal barrier (1)
- intestinal enteroids (1)
- intestinal inflammation (1)
- intestinal organoids (1)
- intestinal parasites (1)
- intestinal permeability (1)
- intramuscular hemorrhage (1)
- intraoperative Boostbestrahlung (1)
- intratumoral microbiota (1)
- intravascular ultrasound (IVUS) (1)
- intravenös (1)
- intubation (1)
- iodine value (1)
- ipsilateral motor evoked potential (1)
- ipsilateral motor network (1)
- irony (1)
- ischemia (1)
- ischemic heart failure (1)
- ischämische Herzinsuffizienz (1)
- ischämischer Schlaganfall (1)
- isentropic Euler equations (1)
- isoliert (1)
- job satisfaction (1)
- judgement (1)
- judgments of learning (1)
- junior studies (1)
- justice (1)
- juvenile hormone (1)
- kardiovaskuläre Risikoevaluation (1)
- kardiovaskulärer Surrogat (1)
- katholische Kirche (1)
- ketamine (1)
- ketogenic dietary therapy (KDT) (1)
- key (1)
- key-insight extraction (1)
- kidney cancer (1)
- kimchi (1)
- kinase (1)
- kinase inhibitor (1)
- kinase signaling (1)
- kinetic equations (1)
- kirchliche Lehre (1)
- kisspeptin (1)
- klinische Studie (1)
- knee (1)
- knee arthroplasty (1)
- knee replacement (1)
- knowledge representation (1)
- kolorektales Karzinom (1)
- kovalent-reversible Hemmung (1)
- kovalent-reversible Inhibitoren (1)
- kovalente und nicht-kovalente Enzym-Inhibitor-Komplexe (1)
- kreuzreaktive T-Zellen (1)
- künstliche Intelligenz (1)
- label-free quantification (1)
- laboratory and online studies (1)
- lactation (1)
- land surface temperature (1)
- land surface-atmosphere interaction (1)
- land-use intensification (1)
- landsat (1)
- landscape complexity (1)
- landscape management (1)
- landwirtschaftlicher Betrieb (1)
- large T antigen (1)
- large animal models (1)
- large‐scale atmospheric circulation modes (1)
- laryngoscopy (1)
- late Na\(^+\) current (I\(_{NaL}\)) (1)
- late enhancement (1)
- late gadolinium-enhancement (1)
- lateral neck abscesses (1)
- law (1)
- layered dissection (1)
- layout recognition (1)
- leaf response (1)
- learning and memory (1)
- learning curve (1)
- learning effect (1)
- learning success (1)
- least cost (1)
- left atrial appendage occlusion (1)
- left ventricular ejection fraction (1)
- length of stay (1)
- level of evidence III (1)
- lidar (1)
- lifestyle habits (1)
- ligands (1)
- light sheet fluorescence microscopy (1)
- light-driven metabolism (1)
- light-induced interstrand DNA crosslinking (1)
- linear regression (1)
- lipidomics (1)
- liquid chromatography–tandem mass spectrometry (LC–MS/MS) (1)
- lithic artefacts (1)
- live-cell imaging (1)
- livestock-associated staphylococci (1)
- local (transient) (1)
- local cell neighborhood (1)
- local culture of knowledge (1)
- local energy system (1)
- local farm management (1)
- local self‐governance (1)
- lock (1)
- locomotor activity (1)
- locomotor adaptation (1)
- locus coeruleus (1)
- logic programming (1)
- long-term analysis (1)
- long-term survivors (1)
- longitudinally extensive transverse myelitis (1)
- low back pain (1)
- low energy metabolism (1)
- low-molecular heparin (1)
- lower extremity (1)
- lower extremity amputation (1)
- luciferase assay (1)
- lung fibrosis (1)
- lying (1)
- lying behavior (1)
- lymph node (1)
- lymph nodes (1)
- lymphatic metastasis (1)
- lymphocyte differentiation (1)
- lysosomal storage disorders (1)
- lysosomaler Overload (1)
- lytic infection (1)
- mHealth (1)
- mRNA expression (1)
- macrophages (1)
- magnesium stearate (1)
- magnetic (1)
- magnetic nanoparticles (1)
- magnetic topological insulator (1)
- main group elements (1)
- major amputation (1)
- major depressive disorder (MDD) (1)
- maligne untere Einflussstauung (1)
- malnourishment (1)
- mandibular (1)
- manufacturing (CAD/CAM) (1)
- marker (1)
- mass spectrometry (1)
- mathematical ability (1)
- mathematical modeling (1)
- mathematics classrooms (1)
- mathematics teaching (1)
- mating strategies (1)
- matrimonio (1)
- maturation strategies (1)
- maxillofacial surgery (1)
- meadow (1)
- mean first passage time (1)
- mechanical alignment (1)
- mechanical power (1)
- mechanical thrombectomy (1)
- mechanism of action (1)
- mechanisms of disease (1)
- media analysis (1)
- medical device training (1)
- medical devices (1)
- medical historian (1)
- medical imaging (1)
- medical nutrition therapy (1)
- medical records (1)
- medical teaching (1)
- medication therapy failure (1)
- medium cut-off dialyzer (1)
- megakaryocyte (1)
- melanoma (1)
- membrane biophysics (1)
- membrane protein (1)
- membrane transporters (1)
- memory formation (1)
- meningioma (1)
- menschliche Gewaltsamkeit (1)
- mental disorders (1)
- mental impairment (1)
- mesenchymal stem cells (1)
- mesenchymal stromal cell (1)
- mesodermal organoid (1)
- mesophyll cells (1)
- meta-data (1)
- metaanalysis (1)
- metabolic disease (1)
- metabolically unhealthy obesity (1)
- metabolite repair (1)
- metabolomics (1)
- metacomprehension (1)
- metagenomics (1)
- metaphor (1)
- metastasis associated in colorectal cancer 1 (MACC1) (1)
- meteorological patterns (1)
- methionine (1)
- methodology (1)
- methylprednisolone (1)
- miR (1)
- miR-126 (1)
- miR-21 (1)
- miR-221 (1)
- miR-26 (1)
- miRNA target (1)
- miRNAs (1)
- micro-CT (1)
- micro-computed-tomography (1)
- microRNA (1)
- microbial diversity (1)
- microbial ecology (1)
- microbiology (1)
- microbiome (1)
- microbiota-derived metabolites (1)
- microglia (1)
- micrometre level microwave ranging (1)
- micronuclei (1)
- micronutrients (1)
- microscopy (1)
- microstates (1)
- mid-infrared wavelength applications (1)
- middle cerebral artery occlusion (1)
- midfrontal theta (MFT) (1)
- migraine (1)
- mild cognitive impairment (1)
- mild hypothermia (1)
- mind-body-intervention (1)
- mindfulness (1)
- mind–body intervention (1)
- miniature schnauzer (1)
- minimally invasive surgery (1)
- minor amputation (1)
- misconceptions (1)
- mitochondrial calcium uniporter (1)
- mitochondrial cardiomyopathy (1)
- mitochondrialer Ryanodin-Rezeptor (mRyR1) (1)
- mitophagy (1)
- mitotic disturbance (1)
- mittlerer transvalvulärer Druckgradient (1)
- mixed methods (1)
- mobile instant messaging (1)
- mobile messaging application (1)
- mobility (1)
- model development (1)
- model output statistics (1)
- model reduction (1)
- modelling (1)
- modified inflation (1)
- moisture convergence (1)
- molecular biology (1)
- molecular capsules (1)
- molecular diagnostics (1)
- molecular evolution (1)
- molecular mechanism (1)
- molecular modeling (1)
- molecular modelling (1)
- molecular movie (1)
- molecular neuroscience (1)
- molekulares Modellieren (1)
- molekulargenetische Charakterisierung (1)
- monarch butterfly (1)
- monetary policy rules (1)
- monocyte subsets (1)
- monocyte-derived dendritic cells (1)
- monocytes (1)
- monolithic grating (1)
- monovalent cation:proton antiporter-2 (CPA2) family (1)
- monozytenderivierte dendritische Zellen (1)
- moral elitism (1)
- morality (1)
- morbidity (1)
- morphology (1)
- mossy fiber synapse (1)
- motion detector (1)
- motivation (1)
- motivational level (1)
- motoneuron (MN) (1)
- motor neurons (1)
- mountain (1)
- mountain biodiversity (1)
- mouse blastocysts (1)
- mouse embryonic stem cells (1)
- mouse xenografts (1)
- mucosal ulcers (1)
- multi-centre (1)
- multi-pinhole collimation (1)
- multi-unit recording (1)
- multicentric (1)
- multidisciplinary (1)
- multilayer perceptron model (1)
- multilingualism (1)
- multimodal intervention (1)
- multipath (1)
- multipath packet scheduling (1)
- multiple action control (1)
- multiscale encoder (1)
- multisensory navigation (1)
- multivariate data analysis (1)
- multi‐model ensemble (1)
- municipality (1)
- murine cytomegalovirus (MCMV) (1)
- muscarinic (1)
- muscarinic acetylcholine receptors (1)
- muscarinic receptors (1)
- muscle (1)
- musculoskeletal system (1)
- museum practice (1)
- mushroom body (1)
- music performance anxiety (1)
- mutation (1)
- mycoplasma (1)
- myelin biology and repair (1)
- myelination (1)
- myeloablation (1)
- myeloid-derived suppressor cells (MDSC) (1)
- myeloma (1)
- myocardial deformation (1)
- myofibroblasts (1)
- nano-CT (1)
- nanofibers (1)
- nanographene (1)
- nanoparticles (1)
- nanoporous (1)
- nanotopography (1)
- nanotopology (1)
- naphthylisoquinoline alkaloids (1)
- narrative effects (1)
- narrative persuasion (1)
- national traditions (1)
- natural processing (1)
- navigation (1)
- near infrared chirality (1)
- near-surface geophysics (1)
- necrobiome (1)
- necroptosis (1)
- neighborhood movement (1)
- neoadjuvant therapies (1)
- neonatal immunology (1)
- neonatal meningitis (1)
- neonate (1)
- network analysis (1)
- network simulation (1)
- neural crest (1)
- neural networks (1)
- neural organoid (1)
- neural stem cell potential (1)
- neuroblastoma cell (1)
- neurodegeneration (1)
- neuroendocrine tumor (1)
- neurofascin (1)
- neurofeedback training (1)
- neurofibromatosis type 1 (1)
- neurofilament light chain (1)
- neurogenesis (1)
- neurologic disease (1)
- neurologin-2 (1)
- neuronal and synaptic plasticity (1)
- neuronal excitability (1)
- neuronal silencing (1)
- neuronavigation (1)
- neuropaticher Schmerz (1)
- neurosphere (1)
- neutrophils (1)
- new media (1)
- news media reporting (1)
- ngEHT (1)
- niedervalente Borverbindungen (1)
- nifedipine (1)
- nodal structures (1)
- node of ranvier (1)
- non-SBI fungicide (1)
- non-aureus staphylococci (1)
- non-cancer controls (1)
- non-fullerene acceptor (1)
- non-fullerene acceptors (1)
- non-muscle myosin (1)
- non-small cell lung cancer (NSCLC) (1)
- non-small-cell lung (1)
- non-suicidal self-injury (1)
- non-terrestrial networks (1)
- non-verbal communication (1)
- nonadiabatic Dynamics (1)
- noncontact monitoring (1)
- nonradiative Relaxation (1)
- non‐fullerene acceptors (1)
- noradrenaline (1)
- norepinephrine transporter (1)
- normal distribution transform (1)
- normal values (1)
- novel human cadaveric perfusion model (1)
- nuclear import (1)
- nuclear localization (1)
- nurse bee (1)
- nursing home residents (1)
- nutrition support (1)
- nystagmus (1)
- o-carborane (1)
- obesity surgery (1)
- object reconstruction (1)
- occupational destinations (1)
- ocular anterior segment perfusion culture (1)
- oculomotor (1)
- off-chain data (1)
- oil seed rape (1)
- oil-seed rape (1)
- oilseed rape (1)
- olfaction (1)
- olfactomedin 4 (1)
- oncobiome (1)
- oncogenic YAP (1)
- oncologist (1)
- oncolytic virus (1)
- one-electron oxidation (1)
- one-health approach (1)
- ontology (1)
- opendsu (1)
- opening of chromatin (1)
- ophthalmic artery (1)
- opsins (1)
- optic nerve (1)
- optic neuritis (1)
- optical clearing (1)
- optimale Herzkatheterprojektionen (1)
- optional angiographic views (1)
- optogenetic (1)
- oral bioavailability (1)
- oral drug absorption (1)
- oral functional capacity (1)
- oral health-related quality of life (1)
- oral squamous cell carcinoma (1)
- oraler Entzündungsstatus (1)
- orales Plattenepithelkarzinom (1)
- orbit (1)
- orbital tomography (1)
- orchestration (1)
- order of growth (1)
- organellar mapping (1)
- organic (1)
- organic farming (1)
- organic light emitting diodes (1)
- organic photovoltaics (1)
- organic solar cell (1)
- organic solar cells (1)
- organoid (1)
- organophosphates (1)
- orientation (1)
- orienting response (1)
- ornaments (1)
- oropharyngeal carcinoma (1)
- orthodontics (1)
- orthognathic surgery (1)
- orthopaedic surgery (1)
- orthopedic surgery (1)
- orthopedics (1)
- oscillation (1)
- osmotic effects (1)
- osteochondral lesion (1)
- osteocutaneous (1)
- osteotomy (1)
- ostial segments (1)
- ovarian cancer (1)
- ovarian tumor (1)
- oxygen/glucose deprivation (1)
- ozone (O3) (1)
- p38 MAPK (1)
- p53 (1)
- p97 VCP Cdc48 (1)
- pH (1)
- pN1 (1)
- packet reception method (1)
- paclitaxel (1)
- paediatric patients (1)
- pain regulation (1)
- pain sensation (1)
- palisade (1)
- pancreas (1)
- pancreatic differentiation (1)
- pandemic (1)
- panel-sequencing (1)
- papillary thyroid carcinoma (PTC) (1)
- parallel imaging (1)
- parasitoid (1)
- parental investment theory (1)
- parotid gland (1)
- partial knee arthroplasty (1)
- particle correlations (1)
- particle picking (1)
- passive transfer (1)
- pasture (1)
- path indistinguishability (1)
- pathogenesis (1)
- patient data (1)
- patient reported outcome measures (1)
- patient safety (1)
- patient-specific implant (1)
- patient-specific instruments (1)
- patients' experience (1)
- pbmc (1)
- pedagogical content knowledge (1)
- pedicle screws (1)
- people with disabilities (1)
- peptide receptor radionuclide therapy (PRRT) (1)
- peptide stapling (1)
- peptidomimetic sequence (1)
- peptidomimetics (1)
- perception and action (1)
- perfluoroarylation (1)
- performance evaluation (1)
- performance monitoring (1)
- performance testing (1)
- perfusion (1)
- perfusion culture (1)
- perfusion map (1)
- pericytes (1)
- periglacial (1)
- perineurium (1)
- periodontal splinting (1)
- peripartum (1)
- periprosthetic osteolysis (1)
- periprothetische Infektion (1)
- permanent employment (1)
- peroxisome purification (1)
- peroxisomes (1)
- personalisierte Medizin (1)
- personality (1)
- personalized medicine (1)
- perylene bisimide (1)
- perylene bisimide dyes (1)
- pesticide mixture (1)
- pharmacology (1)
- pharmacometrics (1)
- pharmacotherapy (1)
- pharmacovigilance (1)
- pharmaledger (1)
- phase space (1)
- phase transition (1)
- phenomenology (1)
- phenotype (1)
- phosphatidylcholines (1)
- phosphoglycolate phosphatase (1)
- phosphoglycolatephosphatase (1)
- phospholipidosis (1)
- phosphoproteome (1)
- photoacoustic (1)
- photocatalysis (1)
- photocontrol (1)
- photon-counting CT (1)
- photon-counting computed tomography (CT) (1)
- photon-counting-detector CT (1)
- photovoltaic (1)
- phthalazinone pyrazole (1)
- phylogenetics (1)
- physical activity promotion (1)
- physical consistency (1)
- physical therapy (1)
- physiological dataset (1)
- physiology (1)
- physiolysis (1)
- physische Morphologie (1)
- phytic acid (1)
- pig (1)
- pig farming methods (1)
- piquetero movement (1)
- pit kilns (1)
- plague (1)
- planetary health (1)
- planetary health education (1)
- planning (1)
- plant development (1)
- plant molecular biology (1)
- plant physiology (1)
- plant signalling (1)
- plant-herbivore interactions (1)
- plant-insect interactions (1)
- plantaris tendinopathy (1)
- plant–herbivore interactions (1)
- platelet activation (1)
- platelet-derived growth factor (1)
- platelet-rich plasma (1)
- pneumoniae (1)
- point-of-care-testing (1)
- pointing interpretation (1)
- policy cycle (1)
- policy evaluation (1)
- policy lab (1)
- policy pilot (1)
- political regime (1)
- political theory (1)
- politische Institution (1)
- politisches Vakuum (1)
- pollen beetle (1)
- pollen tubes (1)
- pollinator (1)
- pollinators (1)
- pollution (1)
- poly(2-ethyl-2-oxazoline) (1)
- poly(2-oxazoline) (1)
- poly(lactic-co-glycolic acid) (1)
- polycaprolactone (1)
- polycyclic aromatic hydrocarbons (1)
- polymers (1)
- polymyalgia rheumatica (1)
- polypharmacy (1)
- polysorbate 80 (1)
- population-based (1)
- pore (1)
- pose tracking (1)
- positive nodal status (1)
- post Marxism (1)
- post-mortem heart recovery (1)
- post-neoadjuvant therapies (1)
- post-transcriptional regulation (1)
- postdoctoral careers (1)
- postoperative Komplikationen (1)
- postoperative Nausea (1)
- postoperative bleeding (1)
- postoperative Übelkeit (1)
- postsynaptic potentials (1)
- posttranscriptional regulation (1)
- posture (1)
- potassium (1)
- potassium channel (1)
- potassium homeostasis (1)
- potenzielles therapeutisches Target (1)
- pre- and post-outbreak comparison (1)
- precision agriculture (1)
- precision medicine (1)
- precision-cut tumor slices (1)
- preclinical education (1)
- preclinical model (1)
- prediction (1)
- prediction error (1)
- predictive modeling (1)
- predictive process analytics (1)
- predictive process monitoring (1)
- preface (1)
- prekäre Arbeit (1)
- prenatal paternal depression (1)
- preoperative (1)
- prescribing omission (1)
- presynaptic (1)
- preterm birth (1)
- prevalence (1)
- preventive medicine (1)
- primary care (1)
- principal (1)
- private chat groups (1)
- pro-inflammatory cytokines (1)
- proboscis extension response (PER) (1)
- process mining (1)
- professional success (1)
- prognostic marker (1)
- programmed cell death (1)
- progression-free survival (1)
- progressive muscle relaxation (1)
- project management (1)
- promoter polymorphism (1)
- proosseointegrativ (1)
- propeller flap (1)
- propofol (1)
- prospective (1)
- prospective study (1)
- prosthetic rehabilitation (1)
- proteasome inhibitor resistance (1)
- proteasome inhibitors (1)
- proteasome subunit beta type-5 (PSMB5) (1)
- proteasome system (1)
- protective behavior (1)
- protective factors (1)
- protein analysis (1)
- protein binding (1)
- protein folding (1)
- protein localization (1)
- proteomics (1)
- protocol (1)
- proxy VAR (1)
- psychiatric rehabilitation (1)
- psychische Belastung (1)
- psychological burden (1)
- psychometrics (1)
- psychopathology (1)
- psychotropic drugs (1)
- psychotropic medication (1)
- puberty (1)
- publication bias (1)
- pulmonale Hypertonie (1)
- pulmonary cancer (1)
- pulmonary embolism (1)
- pulmonary hypertension (1)
- pulse therapy (1)
- punishment (1)
- push-pull stabilization (1)
- pyrene (1)
- pyrrolizidine alkaloids (1)
- qualitative methods (1)
- qualitative research (1)
- quality control (1)
- quality of care (1)
- quantitative 1H NMR (1)
- quantitative SPECT/CT (1)
- quantitative methods (1)
- quantum optics (1)
- quantum spin hall insulator (1)
- quantum wave functions (1)
- quaterrylene bisimide (1)
- qubit interaction (1)
- quiescence (1)
- rBAM2-labeled RNA strands (1)
- rRNA depletion (1)
- radiation dosage (1)
- radiation dose (1)
- radiation dose reduction (1)
- radical (1)
- radical reactions (1)
- radio astronomy (1)
- radiocarbon dating (1)
- radiographic bone loss (1)
- radiomics (1)
- rainfall (1)
- random forest (1)
- random forest regression (1)
- randomized controlled trial (1)
- randomized trial (1)
- range shifts (1)
- ransomware (1)
- rapid prototyping (1)
- raumzeitliche Dynamik (1)
- raw material analysis (1)
- reactivity and selectivity study (1)
- real-time (1)
- real-time PCR (1)
- real-time imaging (1)
- real-world (1)
- reasoning (1)
- reciprocity (1)
- recognition (1)
- recurrence (1)
- recurrent/metastatic head and neck squamous cell carcinoma (1)
- red fruit oil (1)
- reference data (1)
- reflections (1)
- regenerative cooling (1)
- regenerative therapies (1)
- regional climate model (1)
- regional climate models (1)
- registry trial (1)
- regulatory RNA (1)
- regulatory T cells (1)
- rehabilitation (1)
- reinforcement learning (1)
- relationship duration (1)
- reliability (1)
- religion (1)
- remitted/acute phase (1)
- renewable energy policy (1)
- reperfusion injury (1)
- replica (1)
- reporter screen (1)
- representations up to homotopy (1)
- reproducibility of results (1)
- reproductive disorders (1)
- research infrastructure (1)
- research integrity (1)
- resection (1)
- reserpinized rat model (1)
- resilience (1)
- resolution (1)
- resourcebased learning strategies (1)
- respiratory signs and symptoms (1)
- response fractionation (1)
- responsiveness (1)
- ressourcenbezogene Lernstrategien (1)
- resting state (1)
- resting-state (1)
- restrained statehood (1)
- retina (1)
- retinal pigment epithelium (1)
- retrogressive thaw slump (1)
- reversible oxidation (1)
- revitalization (1)
- rezeptorvermittelte Endozytose (1)
- rheumatoid arthritis (1)
- ribosome biogenesis (1)
- right prefrontal cortex (PFC) (1)
- rigidification (1)
- ring strain (1)
- risk SNP rs1397547 (1)
- risk pregnancy (1)
- robotic (1)
- robotic process automation (1)
- rock glaciers (1)
- rocket engine (1)
- rodent model (1)
- rotating magnetic field (1)
- rotations (1)
- räumliche Verteilung (1)
- sRNA (1)
- sacubitril-valsartan (1)
- safety and tolerability (1)
- salivary gland neoplasia (1)
- salivary gland tumor (1)
- salt consumption (1)
- salt metathesis (1)
- salt stress (1)
- salt-and-pepper pattern (1)
- salt-intake-related behavior (1)
- salvage therapy (1)
- saponification Value (1)
- satellite (1)
- satellite communication (1)
- saturation transfer difference NMR (1)
- scaffold-free (1)
- scalability (1)
- scalability evaluation (1)
- scalable functional genomic screening (1)
- school (1)
- science–policy interface (1)
- scurvy (1)
- seasonal dynamics (1)
- second line antibiotics (1)
- secondary infarct growth (1)
- secondary prevention (1)
- seed yield (1)
- self-efficacy (1)
- self-governance (1)
- self-serving dishonesty (1)
- self-sovereign identities (1)
- self-targeting CRISPR-Cas (1)
- selfcompassion (1)
- self‐organisation (1)
- selpercatinib (1)
- senescence (1)
- sensory cues (1)
- sensory ganglia (1)
- sensory neuron (1)
- sentiment analysis (1)
- sentinel (1)
- sentinel-2 (1)
- sequencing (1)
- serielle Rasterelektronenmikroskopie (1)
- seronegative (1)
- serpentinite (1)
- serum (1)
- service-curve estimation (1)
- settlement (1)
- severe acute respiratory syndrome coronavirus 2 (1)
- shape (1)
- shedding (1)
- shortest path routing (1)
- sigma factor (1)
- sigma-1 receptor-directed molecular imaging (1)
- signal transduction (1)
- signaling network (1)
- signaling traffic (1)
- signalling pathways (1)
- signification (1)
- silver (1)
- singe crystal (1)
- single cell analysis (1)
- single particle tracking (1)
- single-cell RNA-seq (1)
- single-molecule biophysics (1)
- single-molecule localization microscopy (1)
- singlet fission (1)
- site mapping (1)
- situation awareness (1)
- situational awareness (1)
- skeletal muscle (1)
- skewed (1)
- skin equivalent (1)
- skinned fiber (1)
- sky kinases (1)
- sleep-disordered breathing disorder (1)
- slice culture (1)
- slow cortical potentials (SCP) (1)
- small RNA (1)
- small RNA expression (1)
- small fiber neuropathy (1)
- small pixel effect (1)
- small-animal SPECT (1)
- small-cell lung (1)
- smart journaling (1)
- smart meter data utilization (1)
- smart speaker (1)
- smoking (1)
- smoking counselling (1)
- social comparisons (1)
- social context (1)
- social inclusion (1)
- social interaction (1)
- social media (1)
- social movements (1)
- social psychology (1)
- social relationship (1)
- social role (1)
- social self‐organization (1)
- social understanding (1)
- sodium (1)
- sodium-glucose co-transporter-2 inhibitors (1)
- software performance (1)
- soil hydrology (1)
- soil moisture (1)
- solid surrogate source (1)
- solid-state emitter (1)
- solid‐state emission (1)
- somatic symptom burden (1)
- southern Alpine flint (1)
- spatial error assessment (1)
- spatial proteomics (1)
- spatio-thematic coverage (1)
- spatiotemporal slump development (1)
- species range shifts (1)
- specific phobia (1)
- speckle tracking (1)
- spectral CT (1)
- spectral imaging (1)
- spectral shaping (1)
- speech motor impairment (1)
- speech recognition (1)
- spezifische Phobie (1)
- spheroids (1)
- spider (1)
- spider phobia (1)
- spin physics (1)
- spin-resolved ARPES (1)
- spinning (1)
- spiral trajectory (1)
- spontane Lautäußerungen (1)
- spontaneous blinks (1)
- sports medicine (1)
- sports therapy (1)
- ssVEP (1)
- standard schnauzer (1)
- staphylococcal abscess (1)
- star products (1)
- state (1)
- state management (1)
- state–society relations (1)
- stationary preserving (1)
- statistical data (1)
- statistics and numerical data (1)
- steatotic liver disease (1)
- stem cell differentiation (1)
- stem cells (1)
- stem weevil (1)
- stereochemistry (1)
- steroid measurement (1)
- strain (1)
- strain rate (1)
- strategy advice (1)
- strategy selection (1)
- stress factors (1)
- stress reduction (1)
- stress response (1)
- strong electronic correlations (1)
- strongyloides infection (1)
- structure (1)
- structured illumination microscopy (1)
- structured light illumination (1)
- structures (1)
- structure–activity relationships (1)
- students with disabilities (1)
- subcutaneous animal model (1)
- subjective perception of wealth (1)
- subjective wealth cues (1)
- subjectivity (1)
- sublethal effect (1)
- sublethal effects (1)
- substance use disorders (1)
- subthalamic nucleus (1)
- subtropical Indian Ocean dipole (1)
- subversiveness (1)
- succession (1)
- suffering (1)
- sugar perception (fructose, sucrose) (1)
- sugar receptor (1)
- sugar responsiveness (1)
- sugars (1)
- suggestions for teaching-arrangements (1)
- suicidality (1)
- super-resolution microscopy (1)
- supportive care intervention (1)
- suppression of women (1)
- suppressive capacity (1)
- suppressor (1)
- supramolecular chemistry (1)
- surface model (1)
- surface scanner (1)
- surgical correction (1)
- surgical treatment (1)
- surrogate model (1)
- sustainability (1)
- sustainable development (1)
- swarming (1)
- sympathetic nervous system (1)
- symptom burden (1)
- symptom control (1)
- symptoms (1)
- synaptic plasticity (1)
- synaptic transmission (1)
- synaptic vesicles (1)
- synergistic effect (1)
- synthesis (1)
- synthetic aperture RADAR (1)
- synthetic biology (1)
- syphilis (1)
- systematic review (1)
- systemic inflammation (1)
- systems biology (1)
- t(14;18)-negative follicular lymphoma (1)
- t(14;18)-negative follikuläre Lymphome (1)
- tDCS (1)
- table extraction (1)
- table understanding (1)
- talent development (1)
- tandem peptide (1)
- tanzania (1)
- task control (1)
- task coordination (1)
- task-order control (1)
- tax avoidance (1)
- taxanes (1)
- teacher education (1)
- technology use (1)
- telehealth (1)
- telemedicine (1)
- telescopes (1)
- temperature (1)
- temporal binding (1)
- temporal processing (1)
- temporary employment (1)
- temporo-parietal junction (1)
- tendon tissue engineering (1)
- tenogenic differentiation (1)
- terminal bar (1)
- test instrument (1)
- testosterone (1)
- tetany (1)
- text line detection (1)
- theory (1)
- theory of science (1)
- theranostics (1)
- therapy (1)
- therapy response (1)
- thinking style (1)
- threat (1)
- three-coordinate borane (1)
- threshold (1)
- thrombin (1)
- thrombo-inflammation (1)
- thromboembolism (1)
- thrombopoiesis (1)
- thyroid carcinoma (TC) (1)
- tierversuchsfrei (1)
- tight junctions (1)
- time frequency analyses (1)
- time series (1)
- time-correlated single photon counting (TCSPC) (1)
- time-dependent Schrodinger equation (1)
- time-resolved (1)
- timestamping method (1)
- tin (1)
- tin prefiltration (1)
- tissue preparation (1)
- tobacco cessation (1)
- tofacitinib (1)
- tools overview (1)
- tooth (1)
- tooth extraction (1)
- topic modeling (1)
- total ankle arthroplasty (1)
- total ankle replacement (1)
- total recall (1)
- toxicity (1)
- trARPES (1)
- trabecular meshwork (1)
- trace elements (1)
- traditional almond orchard (1)
- traditional land use (1)
- trafficking (1)
- training (1)
- training intensity distribution (1)
- transcranial ultrasound neuromodulation/stimulation (TUS) (1)
- transcription factor (1)
- transcriptional regulation (1)
- transcriptional termination site (1)
- transcriptomics (1)
- transference (1)
- transgenic mouse (1)
- transient middle cerebral artery occlusion model (1)
- transkranielle Gleichstromstimulation (tDCS) (1)
- translocation experiment (1)
- transportation (1)
- transthoracic echocardiography (1)
- trastuzumab (1)
- trastuzumab deruxtecan (1)
- traumatic brain injury (1)
- traumatisch (1)
- treatment regimens (1)
- tree cavity (1)
- triarylborane (1)
- triple-negative breast cancer (1)
- triplet excitons (1)
- triptan (1)
- trispecific (1)
- truth (1)
- tuber (1)
- tuberculosis (1)
- tumor microenvironment (TME) (1)
- tumor treating fields (1)
- tumormicroenvironment (1)
- tumors (1)
- tumour (1)
- tumour immunology (1)
- two-dimensional topological insulator (1)
- ubiquitin proteasome system (1)
- ultra-low-dose CT (1)
- ultrafiltration (1)
- ultrahigh resolution (1)
- ultrahigh-field MRI (1)
- uncooperative space rendezvous (1)
- underutilized legumes (1)
- underwater 3D scanning (1)
- unethical behaviour (1)
- unicompartmental knee arthroplasty (1)
- universal prevention (1)
- unklarer Signifikanz (1)
- upper limb (1)
- upslope shift (1)
- urbane Lebensmittellieferant:innen (1)
- urbane Strukturanalyse (1)
- urinary calculi (1)
- urinary tract infections (1)
- usability (1)
- user identification (1)
- user-centered design (1)
- user-centred design (1)
- vDEUQUA2021 (1)
- vacuolar calcium sensor (1)
- vacuum processable (1)
- vagal threshold (1)
- valence framing (1)
- validation study (1)
- vascular structure (1)
- vasculature (1)
- vasp (1)
- vdr (1)
- ve-cadherin (1)
- vegetation (1)
- venous infiltration (1)
- ventilation (1)
- verbal n-back (1)
- vertebral pedicles (1)
- very long baseline interferometry (1)
- vestibular aqueduct (1)
- vestibular schwannoma (1)
- vestibulärer Aquädukt (1)
- video games (1)
- video object detection (1)
- video-assisted laryngoscopy (1)
- videooculography (1)
- vincristine (1)
- vineyard terrace (1)
- viral genome packaging (1)
- viral infection (1)
- viral miRNAs (1)
- virology (1)
- virtual non-contrast (1)
- virtual reality exposure therapy (1)
- virusspezifische T-Zellen (1)
- vision (1)
- visual cue (1)
- visual memory (1)
- visual perception (1)
- visual processes (1)
- visual proteomics (1)
- vitamin d (1)
- vitamin d receptor (1)
- vitamins (1)
- voltage gating (1)
- volumetric modulated arc therapy (1)
- voluntary movement (1)
- waggle dance decoding (1)
- walkability (1)
- walking (1)
- warhead (1)
- wax (1)
- weak statehood (1)
- wealth estimation (1)
- weight-bearing (1)
- well-balanced scheme (1)
- white blood cells (1)
- white matter disease (1)
- whole-body imaging (1)
- wild honey bees (1)
- wild plants (1)
- wild-living honey bees (1)
- wildlife-friendly farming (1)
- women (1)
- workshop (1)
- wrong labelling (1)
- x-ray spectroscopy (1)
- xiphophorus (1)
- yam (1)
- zentrale Spindel und Mittelkörper (1)
- zerebelläre Gleichstromstimulation (1)
- zervikale Lymphknotenmetastasen (1)
- zinc oxide (1)
- zonulin (1)
- zoology (1)
- zweigeteilte trivalente T-Zell-aktivierende Antikörperderivate (1)
- Älteste Linearbandkeramik (1)
- Ängstlichkeit/Depressivität (1)
- Äquivalenzprinzip (1)
- Ätiologie (1)
- Übelkeit (1)
- Überexpression (1)
- Übergangsmetall (1)
- Übergangsmetalldichalkogenide (1)
- Überleben (1)
- Übernahmeaufforderung (1)
- Überzeugungen (1)
- ästhetische Ergebnisse (1)
- öffentlicher Dienst (1)
Institute
- Graduate School of Life Sciences (131)
- Theodor-Boveri-Institut für Biowissenschaften (87)
- Institut für Informatik (47)
- Medizinische Klinik und Poliklinik I (47)
- Institut für Psychologie (46)
- Medizinische Klinik und Poliklinik II (45)
- Neurologische Klinik und Poliklinik (41)
- Universität - Fakultätsübergreifend (40)
- Lehrstuhl für Orthopädie (35)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (33)
Schriftenreihe
Sonstige beteiligte Institutionen
- Helmholtz Institute for RNA-based Infection Research (HIRI) (2)
- Interdisziplinäres Zentrum für Klinische Forschung (IZKF) (2)
- Klinische Studienzentrale (Universitätsklinikum) (2)
- Naturalis Biodiversity Centre (2)
- Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg (2)
- Akademie der Wissenschaften und der Literatur, Mainz (1)
- Anthropology Department University of Tennessee, Knoxville (1)
- Bungando Medical Centre, Mwanza, Tanzania (1)
- CHC Würzburg (Comprehensive Hearing Center) (1)
- CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg (1)
Now that mechanical thrombectomy has substantially improved outcomes after large-vessel occlusion stroke in up to every second patient, futile reperfusion wherein successful recanalization is not followed by a favorable outcome is moving into focus. Unfortunately, blood-based biomarkers, which identify critical stages of hemodynamically compromised yet reperfused tissue, are lacking. We recently reported that hypoxia induces the expression of endoglin, a TGF-β co-receptor, in human brain endothelium in vitro. Subsequent reoxygenation resulted in shedding. Our cell model suggests that soluble endoglin compromises the brain endothelial barrier function. To evaluate soluble endoglin as a potential biomarker of reperfusion (-injury) we analyzed its concentration in 148 blood samples of patients with acute stroke due to large-vessel occlusion. In line with our in vitro data, systemic soluble endoglin concentrations were significantly higher in patients with successful recanalization, whereas hypoxia alone did not induce local endoglin shedding, as analyzed by intra-arterial samples from hypoxic vasculature. In patients with reperfusion, higher concentrations of soluble endoglin additionally indicated larger infarct volumes at admission. In summary, we give translational evidence that the sequence of hypoxia and subsequent reoxygenation triggers the release of vasoactive soluble endoglin in large-vessel occlusion stroke and can serve as a biomarker for severe ischemia with ensuing recanalization/reperfusion.
Variability of gene expression due to stochasticity of transcription or variation of extrinsic signals, termed biological noise, is a potential driving force of cellular differentiation. Utilizing single-cell RNA-sequencing, we develop VarID2 for the quantification of biological noise at single-cell resolution. VarID2 reveals enhanced nuclear versus cytoplasmic noise, and distinct regulatory modes stratified by correlation between noise, expression, and chromatin accessibility. Noise levels are minimal in murine hematopoietic stem cells (HSCs) and increase during differentiation and ageing. Differential noise identifies myeloid-biased Dlk1+ long-term HSCs in aged mice with enhanced quiescence and self-renewal capacity. VarID2 reveals noise dynamics invisible to conventional single-cell transcriptome analysis.
Psychotropic drugs are frequently prescribed ‘off-label’ to children and adolescents and carry the risk of serious adverse drug reactions (sADR). We examined the frequency of sADRs of psychotropic drugs in pediatric inpatients and explored their potential preventability through following the recommendations of a web-based pediatric drug information system (PDIS). The potential socio-economic impacts of using this online system is also addressed. Routine clinical data from all inpatients treated in a child and adolescent psychiatry department between January 2017 and December 2018 were retrospectively examined for the occurrence of sADRs as defined by the European Medicines Agency. The preventability of the sADRs was assessed based on the information of the PDIS. Furthermore, the expected prolongation of the hospital stay due to sADRs was calculated as well as the associated treatment costs. The study was supported by the Innovation Fund of the Joint Federal Committee, grant number 01NVF16021. In total, 1036 patients were screened of whom 658 (63.5%) received psychopharmacological treatment. In 53 (8.1%) of these patients 54 sADRs were documented, of which 37 sADRs were identified as potentially preventable through PDIS. Mitigating sADR through PDIS would likely have prevented prolonged hospital stays and conferred considerable savings for health insurance companies. PDIS provides systematic and evidence-based information about pediatric psychopharmacotherapy and helps to prevent prescribing errors. Therefore, PDIS is a useful tool to increase drug therapy safety in child and adolescent psychiatry. Further prospective studies are needed to confirm the results.
Valence framing effects refer to inconsistent choice preferences in response to positive versus negative formulation of mathematically equivalent outcomes. Here, we manipulate valence framing in a two-alternative forced choice dictator game using gains and losses as frames to investigate the cognitive mechanisms underlying valence framing. We applied a Drift-Diffusion Model (DDM) to examine whether gain (i.e., “take” money) and loss (i.e., “give” money) frames evoke a cognitive bias as previous research did not consistently reveal framing effects using reaction times and response frequency as dependent variables. DDMs allow decomposing the decision process into separate cognitive mechanisms, whereby a cognitive bias was repeatedly associated with a shift in the starting point of the model. Conducting both a laboratory (N = 62) and an online study (N = 109), female participants allocated money between themselves and another person in a prosocial or selfish way. In each study, one group was instructed to give money (give frame), the other to take money (take frame). Consistent with previous studies, no differences were found in response times and response frequencies. However, in both studies, substantial bias towards the selfish option was found in the take frame groups, captured by the starting point of the DDM. Thus, our results suggest that valence framing induces a cognitive bias in decision processing in women, even when no behavioral differences are present.
This paper presents a prototypical implementation of the In-band Network Telemetry (INT) specification in P4 and demonstrates a use case, where a Tofino Switch is used to measure device and network performance in a lab setting. This work is based on research activities in the area of P4 data plane programming conducted at the network lab of HTW Berlin.
Background: Due to the importance of radiologic examinations, such as X-rays or computed tomography scans, for many clinical diagnoses, the optimal use of the radiology department is 1 of the primary goals of many hospitals.
Objective: This study aims to calculate the key metrics of this use by creating a radiology data warehouse solution, where data from radiology information systems (RISs) can be imported and then queried using a query language as well as a graphical user interface (GUI).
Methods: Using a simple configuration file, the developed system allowed for the processing of radiology data exported from any kind of RIS into a Microsoft Excel, comma-separated value (CSV), or JavaScript Object Notation (JSON) file. These data were then imported into a clinical data warehouse. Additional values based on the radiology data were calculated during this import process by implementing 1 of several provided interfaces. Afterward, the query language and GUI of the data warehouse were used to configure and calculate reports on these data. For the most common types of requested reports, a web interface was created to view their numbers as graphics.
Results: The tool was successfully tested with the data of 4 different German hospitals from 2018 to 2021, with a total of 1,436,111 examinations. The user feedback was good, since all their queries could be answered if the available data were sufficient. The initial processing of the radiology data for using them with the clinical data warehouse took (depending on the amount of data provided by each hospital) between 7 minutes and 1 hour 11 minutes. Calculating 3 reports of different complexities on the data of each hospital was possible in 1-3 seconds for reports with up to 200 individual calculations and in up to 1.5 minutes for reports with up to 8200 individual calculations.
Conclusions: A system was developed with the main advantage of being generic concerning the export of different RISs as well as concerning the configuration of queries for various reports. The queries could be configured easily using the GUI of the data warehouse, and their results could be exported into the standard formats Excel and CSV for further processing.
Usability of a mHealth solution using speech recognition for point-of-care diagnostic management
(2023)
The administrative burden for physicians in the hospital can affect the quality of patient care. The Service Center Medical Informatics (SMI) of the University Hospital Würzburg developed and implemented the smartphone-based mobile application (MA) ukw.mobile1 that uses speech recognition for the point-of-care ordering of radiological examinations. The aim of this study was to examine the usability of the MA workflow for the point-of-care ordering of radiological examinations. All physicians at the Department of Trauma and Plastic Surgery at the University Hospital Würzburg, Germany, were asked to participate in a survey including the short version of the User Experience Questionnaire (UEQ-S) and the Unified Theory of Acceptance and Use of Technology (UTAUT). For the analysis of the different domains of user experience (overall attractiveness, pragmatic quality and hedonic quality), we used a two-sided dependent sample t-test. For the determinants of the acceptance model, we employed regression analysis. Twenty-one of 30 physicians (mean age 34 ± 8 years, 62% male) completed the questionnaire. Compared to the conventional desktop application (DA) workflow, the new MA workflow showed superior overall attractiveness (mean difference 2.15 ± 1.33), pragmatic quality (mean difference 1.90 ± 1.16), and hedonic quality (mean difference 2.41 ± 1.62; all p < .001). The user acceptance measured by the UTAUT (mean 4.49 ± 0.41; min. 1, max. 5) was also high. Performance expectancy (beta = 0.57, p = .02) and effort expectancy (beta = 0.36, p = .04) were identified as predictors of acceptance, the full predictive model explained 65.4% of its variance. Point-of-care mHealth solutions using innovative technology such as speech-recognition seem to address the users’ needs and to offer higher usability in comparison to conventional technology. Implementation of user-centered mHealth innovations might therefore help to facilitate physicians’ daily work.
Ureaplasma species (spp.) are considered commensals of the adult genitourinary tract, but have been associated with chorioamnionitis, preterm birth, and invasive infections in neonates, including meningitis. Data on mechanisms involved in Ureaplasma-driven neuroinflammation are scarce. The present study addressed brain inflammatory responses in preterm lambs exposed to Ureaplasma parvum (UP) in utero. 7 days after intra-amniotic injection of UP (n = 10) or saline (n = 11), lambs were surgically delivered at gestational day 128–129. Expression of inflammatory markers was assessed in different brain regions using qRT-PCR and in cerebrospinal fluid (CSF) by multiplex immunoassay. CSF was analyzed for UP presence using ureB-based real-time PCR, and MRI scans documented cerebral white matter area and cortical folding. Cerebral tissue levels of atypical chemokine receptor (ACKR) 3, caspases 1-like, 2, 7, and C–X–C chemokine receptor (CXCR) 4 mRNA, as well as CSF interleukin-8 protein concentrations were significantly increased in UP-exposed lambs. UP presence in CSF was confirmed in one animal. Cortical folding and white matter area did not differ among groups. The present study confirms a role of caspases and the transmembrane receptors ACKR3 and CXCR4 in Ureaplasma-driven neuroinflammation. Enhanced caspase 1-like, 2, and 7 expression may reflect cell death. Increased ACKR3 and CXCR4 expression has been associated with inflammatory central nervous system (CNS) diseases and impaired blood–brain barrier function. According to these data and previous in vitro findings from our group, we speculate that Ureaplasma-induced caspase and receptor responses affect CNS barrier properties and thus facilitate neuroinflammation.
Bei Patienten mit Erkrankungen des blutbildenden Systems ist die hämatopoetische Stammzelltransplantation (HSZT) eine häufig eingesetzte kurative Therapie. Im Rahmen dieser Transplantation werden nicht nur vom Spender gewonnene hämatopoetische Stammzellen auf den Empfänger übertragen, sondern immer auch im peripheren Blut vorhandene T-Zellen. Dies kann zum einen einen positiven Effekt zum anderen aber auch negative Folgen für den transplantierten Patienten mit sich bringen. Eine negative Auswirkung wäre die sogenannte Graft-vesus-Host Disease (GvHD), bei der die T-Zellen des Spenders Zellen des Empfängers als fremd erkennen und angreifen. Klinisch manifestiert sich dies vor allem an Leber, Haut und Darm mit Ikterus, Dermatitiden und Diarrhoen. Einen gewünschten Effekt, den die übertragenen T-Zellen vor allem bei Patienten mit akuter myeloischer Leukämie (AML) mit sich bringen können, ist der sogenannte Graft-versus-Leukemia (GvL) Effekt. Dabei richten sich vom Spender stammende Immunzellen gegen die Tumorzellen des Empfängers und senken damit das Rezidivrisiko der Leukämie.
In verschiedenen Studien konnte eine positive Korrelation von CMV-Reaktivierung nach HSZT und einem niedrigerem Rezidivrisiko der hämatopoetischen Grunderkrankung gezeigt werden. Diese Doktorarbeit widmet sich auf Grundlage dessen der Frage, ob Cytomegalievirus (CMV)-spezifische cytotoxische T-Zellen (CTL) direkt durch Kreuzreaktivität zum GvL-Effekt beitragen.
Zunächst wurden periphere mononukleäre Zellen (PBMC) aus dem Blut neun gesunder Spender isoliert, die als CMV-seropositiv ausgetestet wurden. Diese wurden mit dem CMVpp65-(NLVPMVATV)-Einzelpeptid stimuliert und in Kultur angereichert. Zusätzlich wurden die expandierten CMV-spezifischen CTL durch eine spezifische Selektion über den Aktivierungsmarker CD137 weiter angereichert. Nach Expansion und Anreicherung zeigten jeweils 75% (Spender 1), 67% (Spender 2), 74% (Spender 3), 86% (Spender 4), 81% (Spender5), 80% (Spender 6), 84% (Spender 7), 51% (Spender 8) und 69% (Spender 9) der CD3+/CD8+-T-Zellen eine IFN-γ-Produktion und CD107a-Expression nach Stimulation mit dem CMVpp65-Einzelpeptid. IFN-γ als Effektormolekül der zytotoxischen Granula der CTL und CD107a als Degranulationsmarker beweisen die spezifische Zytotoxizität. Somit konnte die erfolgreiche Anreicherung funktionsfähiger CMVpp65-spezifischer CTL gezeigt werden. Um zu untersuchen, ob diese nun kreuzreaktiv tumorassoziierte Antigene (TAA) erkennen, wurden sie ebenfalls mit folgenden TAA stimuliert: WT1, Proteinase 3, PRAME, NY-ESO, Muc1 und Bcl-2. Die Stimulation erfolgte entweder über die direkte Zugabe von Einzelpeptiden bzw. Peptidpools oder über die Beladung und Präsentation dieser Peptide bzw. Peptidpools über dendritische Zellen (DC). Die DC wurden aus Monozyten des jeweiligen Spenders generiert. Im Falle von drei Spendern zeigt sich ebenfalls eine deutliche zytotoxische Funktion nach Stimulation mit dem WT1-(DFKDCERRF)-Einzelpeptid durch IFN-γ-Produktion und CD107a-Expression bei 75% (Spender 1), 35% (Spender 4) und 33% (Spender 7) der CD3+/CD8+-T-Zellen. Wie zuvor erwähnt lag der Anteil der CD3+/CD8+-T-Zellen mit spezifischer Zytotoxizität nach Stimulation mit dem CMVpp65-(NLVPMVATV)-Einzelpeptid bei diesen drei besagten Spendern bei 74% (Spender1), 86% (Spender 4) und 84% (Spender7). So ergab sich für diese drei Spender eine gemeinsame Schnittmenge von 48,92% (Spender 1), 21,07% (Spender 4) und 17,45% (Spender 7) derjenigen Zellen, die sowohl nach Stimulation mit CMVpp65-(NLVPMVATV)-Einzelpeptid und WT-(DFKDCERRF)-Einzelpeptid eine zytotoxische Funktion zeigten, sodass von einer kreuzreaktiven Erkennung dieser beiden Peptide in diesen drei Spendern ausgegangen werden muss. Die für diese Spender gezeigte kreuzreaktive Erkennung könnte zum GvL-Effekt bei Leukämie/Myelom-Patienten nach HSZT beitragen.
Ein Schlüsselereignis, welches dem prognosebestimmenden Organversagen bei systemi-schen Entzündungsprozessen und Sepsis vorangeht, ist die Entwicklung einer mikrovas-kulären endothelialen Schrankenstörung. Das vaskuläre endotheliale (VE-) Cadherin als mechanischer Stabilisator der Endothelbarriere spielt dabei eine wichtige Rolle. In der Inflammation werden Spaltprodukte von VE-Cadherin (sVE-Cadherin) gebildet. Ge-genstand der vorliegenden Arbeit war die Untersuchung der Hypothese ob diese Spalt-produkte selbst an der Störung der endothelialen Barrierefunktion beteiligt sind.
Es wurde hierfür humanes sVE-Cadherin bestehend aus den extrazellulären Domänen EC1-5 (sVE-CadherinEC1-5) generiert. In Messungen des transendothelialen elektrischen Widerstands (TER), mit Immunfluoreszenzfärbungen und Western Blot Analysen wird gezeigt, dass sVE-Cadherin dosisabhängig die Barriere Integrität in primären humanen dermalen Endothelzellen stört. Dies führt zu einer Reduktion von VE-Cadherin und den assoziierten Proteinen α-, γ- und δ-Catenin und ZO-1, die nach der Applikation von sVE-Cadherin an den Zellgrenzen reduziert sind. Die Interaktion zwischen VE-PTP und VE-Cadherin wird durch sVE-CadherinEC1-5 reduziert. Durch pharmakologische Hem-mung der Phosphataseaktivität von VE-PTP mittels AKB9778 wird der durch sVE-CadherinEC1-5-induzierte Verlust der Endothelbarriere aufgehoben. Dagegen zeigt die direkte Aktivierung von Tie-2 mittels Angiopoetin-1 keinen protektiven Effekt auf die durch sVE-CadherinEC1-5 gestörte Endothelbarriere. Weitere Analysen zeigen eine erhöh-te Expression von GEF-H1 durch sVE-CadherinEC1-5. Diese ist ebenfalls durch AKB9778 hemmbar.
Zusätzlich zu diesen Untersuchungen wurden die Konstrukte EC1-4 und EC3-5 in ver-schiedene Vektoren kloniert, um zu bestimmen, ob die extrazelluläre Domäne 5 von VE-Cadherin die dominante Rolle bei den sVE-Cadherin-vermittelten Effekten spielt.
Zusammenfassend zeigen diese Untersuchungen zum ersten Mal, dass sVE-CadherinEC1-5 unabhängig von proinflammatorischen Auslösern über die Aktivierung des VE-PTP/RhoA-Signalweges den Zusammenbruch der Endothelbarriere mitversursacht. Dies stellt einen neuen pathophysiologischer Mechanismus dar, der zum Gesamtverständnis der entzündungsinduzierten Barriereveränderungen des Endothels beiträgt.
In der vorliegenden Dissertation wurde das Zusammenspiel von enterischen Gliazellen (EGC) und Darmepithelzellen (Caco-2) thematisiert, wobei der Fokus auf der Bedeu-tung des neurotrophen Faktors GDNF für die Interaktion zwischen den beiden genann-ten Zelltypen lag. Weiterhin wurde evaluiert, ob die Tyrosinkinase RET auch in Darme-pithelzellen für die GDNF-Signaltransduktion unter Ruhebedingungen und bei Entzün-dungen verantwortlich ist.
Als Grundlage diente ein Ko-Kultur-Modell mit Caco-2 und EGC. Durch Permeabili-täts- und Widerstandsmessungen wurden die Auswirkungen von GDNF auf Zell-Monolayer ermittelt. Effekte auf die Barrieredifferenzierung wurden anhand subkon-fluenter Zell-Monolayer charakterisiert, wohingegen die Auswirkungen auf Entzün-dungsstimuli an konfluenten Zellen untersucht wurden. Veränderungen von Junktions-proteinen wurden mit Immunfluoreszenzfärbungen und Western-Blot-Analysen aufge-zeigt. Abschließend erfolgte eine Analyse humaner Gewebeproben von Patienten mit und ohne chronisch-entzündlichen Darmerkrankungen (CED) in Bezug auf deren GDNF-Expression.
Die verwendeten intestinalen Epithelzellen exprimieren die GDNF-Rezeptoren GFRα1, GFRα2, GFRα3 und RET. Nach Etablierung des Kultursystems zeigten Permeabilitäts-messungen, Messungen des Epithelwiderstandes sowie Immunfluoreszenz-Färbungen, dass die Differenzierung der Darmepithelzellen in der Ko-Kultur mit EGC durch GDNF vermittelt wird. Zudem war eine GDNF-abhängige, barrierestabilisierende Wirkung in einem Inflammationsmodell zu beobachten. Weiterhin wurde nachgewiesen, dass GDNF-Effekte auf Enterozyten auch im Darmepithel über die RET-Tyrosinkinase mit nachfolgender Hemmung des p38-MAPK-Signalwegs bedingt werden. Eine Stimulation der EGC mit Zytokinen bestätigte eine Hochregulation der GDNF-Expression und Sek-retion. In humanen Proben war intestinales GDNF bei schwerer Entzündung reduziert.
Zusammenfassend wurde erstmalig der Nachweis erbracht, dass von EGC sezerniertes GDNF die Differenzierung der Barriere in Darmepithelzellen induziert und diese gegen einen Zytokin-vermittelten Zusammenbruch schützt. Dies wird über eine RET-abhängige Regulation der p38-MAPK vermittelt. Die Reduktion der GDNF-Konzentration in transmuralen Gewebeproben von Patienten mit CED trägt möglicher-weise zur Pathogenese der CED bei.
Tumore von Kopf und Hals gehen weiterhin mit einer schlechten Prognose einher. Im Rahmen einer operativen Therapie tritt Wundsekret (WS) aus, welches der Wundheilung dient. Dieses kann in Kontakt mit Tumorzellen bzw. Resttumor in der Wunde kommen.
Im Rahmen der vorliegenden Arbeit wurde die Frage nach dem Einfluss von Wundsekret auf Zellvermehrung, Chemoresistenzentwicklung, den Zellzyklus und die Induktion einer Epithelial-mesenchymalen Transition (EMT) in Tumorzellen von Kopf und Hals gestellt.
Hierfür wurde das WS von Tag1 und das WS von Tag 2 im Dotblot auf seine Zytokinzusammensetzung analysiert. Zwei Tumorzelllinien von Kopf und Hals, FaDu und HlaC78, wurden mit WSTag1 und WSTag2 behandelt und untersucht, welche Effekte das WS auf die Zellen hat.
Verwendet wurden ein Proliferationsassay, eine Zellzyklusuntersuchung und Apoptosetestung mittels FACS, eine PCR, ein Spheroidmodell und die Lichtmikroskopie.
Im WS wurden erhöhte Konzentrationen verschiedener Zytokine, insbesondere von IL-6, nachgewiesen. Gezeigt werden konnte eine gesteigerte Proliferationsrate der Tumorzellen unter WS-Behandlung, jedoch keine veränderte Verteilung der Zellzyklusphasen. In HlaC78-Zellen konnte eine vermehrte Vitalität nach Cisplatinbehandlung nachgewiesen werden. In beiden Tumorzelllinien fand sich eine vermehrte Exprimierung von Snail 1, Snail 2 und Vimentin. E-Cadherin wurde vermindert exprimiert. Twist und N-Cadherin wiesen keine Veränderungen auf. Es zeigte sich eine vermehrte Migration der Tumorzellen in die Umgebung. Die Zellen wiesen nach Behandlung mit WS vermehrt mesenchymale Zeichen auf. Es konnte kein Unterschied der Auswirkungen einer Behandlung mit WSTag1 im Vergleich zu einer Behandlung mit WSTag2 festgestellt werden.
Insgesamt scheint WS in Tumorzellen von Kopf und Hals einen EMT-artigen Prozess in Gang zu setzen, also eine partial EMT (pEMT).
Als mögliche Auslöser dieser Veränderungen kommen die im WS nachgewiesenen Zytokine und v. a. IL-6 in Frage.
In der vorliegenden Arbeit wurde das Vorkommen neu erworbener N-Glykosylierungsmotive in t(14;18)-positiven und -negativen FL der lokalisierten (FL I/II) und fortgeschrittenen Stadien (FL III/IV), sowie zum Zeitpunkt der Primärdiagnose und des Rezidivs untersucht. Dabei wurde der jeweilige Haupttumorklon mit Hilfe von „Next Generation Sequencing“ und unter Verwendung des „LymphoTrack® Assays“ in einer Serie von 68 kryoasservierten FL identifiziert 36 t(14;18)-negative und 32 t(14;18)-positive FL. Die Frequenz neu erworbener N-Glykosylierungsmotive unterschied sich signifikant zwischen t(14;18)-positiven und -negativen PD/R-FL III/IV, während man zwischen t(14;18)-positiven und -negativen PD/R-FL I/II keinen Unterschied beobachten konnte. Des Weiteren zeigten t(14;18)-negative PD/R-FL I-IV im Vergleich zu t(14;18)-positiven PD/R-FL I-IV signifikant häufiger einen Zugewinn neuer N-Glykosylierungsmotive in der FR3 Region des BCL2 Gens, sowie eine vermehrte Nutzung des IGHV4-34 Keimbahngens. Interessanterweise beschränkte sich die Nutzung des IGHV4-34 Gens auf PD-FL und konnte in R-FL nicht nachgewiesen werden. Da sowohl das Vorkommen neu erworbener N-Glykosylierungsmotive in FR3 als auch die Nutzung von IGHV4-34 im Zusammenhang mit Autoimmunerkrankungen beschrieben wurden, deuten unsere Ergebnisse darauf hin, dass die Subgruppe der t(14;18)-negativen FL im pathologischen Prozess der Onkogenese mehr auf die Stimulation durch (Auto)-Antigene als durch die Stimulation des B-Zell Rezeptors mit Lektinen (DC-SIGN) angewiesen sein könnte.
PONV ist eine häufige und für Patient*innen belastende Nebenwirkung nach einer Allgemeinanästhesie. Trotz der Vielzahl an Studien zu den zahlreichen antiemetischen Medikamenten gibt es bisher keinen Überblick über die Effizienz und Sicherheit all dieser Medikamente. Im Rahmen des Cochrane-Reviews „Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis“ wurden RCTs zur Prävention von PONV nach Allgemeinanästhesie bei Erwachsenen gesucht. Zu den primären Endpunkten gehörten Erbrechen 0-24 Stunden, schwere unerwünschte Ereignisse und unerwünschte Ereignisse, zu den sekundären Endpunkten Substanz-spezifische Nebenwirkungen, frühes und spätes postoperatives Erbrechen, Übelkeit und vollständiger Behandlungserfolg. In dieser Dissertation wurden die Vergleiche mit mindestens zehn Studien auf das Vorliegen eines Publikationsbias überprüft. Die Beurteilung des Publikationsbias erfolgte unter Anwendung verschiedener Tests (Funnel Plots, contour-enhanced Funnel Plot, Arcsine Test, Trim-and-Fill-Methode). Bei sieben von den 64 analysierten Vergleichen wurde der Verdacht auf einen Publikationsbias gestellt. Für den primären Endpunkt Erbrechen 0-24 Stunden wurde bei zwei Vergleichen (Droperidol vs. Placebo und Metoclopramid vs. Ondansetron) ein Publikationsbias vermutet, für die sekundären Endpunkte Übelkeit bei drei Vergleichen (Tropisetron vs. Placebo, Dexamethason-Ondansetron vs. Dexamethason, Dexamethason-Ondansetron vs. Ondansetron) und für den vollständigen Behandlungserfolg bei zwei Vergleichen (Droperidol vs. Placebo, Ondansetron vs. Placebo). Die Effektschätzer der restlichen 54 Vergleiche sind hinsichtlich der klinischen Relevanz robust und eine Verzerrung durch einen Publikationsbias wurde nicht vermutet.
Die Auswirkungen der chirurgischen und konservativen Adipositastherapie auf das Metabolom sind bisher nicht eindeutig geklärt. Der Veränderung bestimmter Metaboliten, darunter den verzweigtkettigen Aminosäuren (BCAA) und den langkettigen Phosphatidylcholinen (PC) bzw. Lecithinen, wird eine tragende Rolle im Zucker- und Fettstoffwechsel zugesprochen. Eine Erhebung von metabolomischen Profilen und deren funktionelle Aufteilung in Aminosäuren- und Lipidprofile bietet eine neue Möglichkeit zur Charakterisierung des Stoffwechsels. Im Vergleich zu der konservativen Therapie wurde nach der RYGB Operation ein signifikanter Anstieg der Lecithine sowie ein signifikanter Abfall der BCAA festgestellt, welche als mögliche Biomarker des Zucker- und Fettstoffwechsels gezeigt wurden. In Zusammenschau der Ergebnisse kann angenommen werden, dass die chirurgische Therapie der konservativen Therapie, wie sie in der WAS durchgeführt wurde, im Hinblick auf den Gewichtsverlust und die Verbesserung des Zucker- und Fettstoffwechsels überlegen ist. Die Erhebung des Metaboloms bietet eine neue Möglichkeit Unterschiede im Stoffwechsel nach Adipositastherapie abzubilden und Metaboliten zu identifizieren, welche mit dem Zucker- und Fettstoffwechsel assoziiert sind.
Die ERK2Thr188-Autophosphoylierung stellt einen regulatorischen Signalweg dar, der infolge einer hypertrophen Stimulation die kardiale Hypertrophie begünstigt. Eine Hemmung dieser Phosphorylierung in Kardiomyozyten verhindert die Ausbildung der kardialen Hypertrophie ohne Beeinflussung der kardioprotektiven Funktionen von ERK1/2. Demgegenüber führt die dauerhafte Simulation zu einem gain-of-function-Phänotypen mit ausgeprägter Hypertophie, Fibrose und einer reduzierten Herzfunktion. In dieser Arbeit wurde die dauerhafte Simulation ERK2Thr188-Phosphorylierung (T188D) in einem Mausmodell mit ubiquitärer Expression dieser Mutation untersucht. Dabei konnte gezeigt werden, dass sich nach Stimulation durch TAC in diesen Tieren ein etwas stärkerer hypertropher Phänotyp mit vergrößerten Kardiomyozyten, gesteigerter interstitieller Fibrosierung und reduzierter Herzfunktion ausbildet als in Mäusen mit kardiomyozyten-spezifischer Überexpression diese Mutante. In Fibroblasten- und VSMC-Zelllinien wurde eine gesteigerte Proliferation der T188D-überexprimierenden Zellen im Vergleich zu Kontrollen festgestellt. Somit scheint die ERK2Thr188-Phosphorylierung auch in kardialen Nicht-Myozyten einen maladaptiven Einfluss auf das Herz auszuüben.
Zusammenfassung
Hintergrund: Das saure Gliafaserprotein (GFAP) kommt im ZNS vor allem in Astrozyten vor und spielt eine Rolle bei der Astrozytose, die wiederum ist ein pathogenetisches Merkmal von HIV-assoziierten neurologischen Erkrankungen (HAND). In dieser Arbeit wird das Vorkommen von GFAP-Autoantikörpern bei PLWH und deren Bedeutung bei der Entstehung von HAND untersucht. Außerdem wird eruiert, ob GFAP-Autoantikörper als Marker eines neurokognitiven Defizites bei HAND in Frage kommen.
Methoden: Homogenisiert Gewebeschnitte von verschiedenen Gehirnareale wurden mittels SDS-Gelelektrophorese und Western Blot auf Membranen übertragen. Diese Membranen wurden mit Blutproben aus der HAND-1 Studie inkubiert. Der Nachweis von GFAP-Antikörpern erfolgte indirekt mittels eines IgG-Antikörpers. Die Anti-GFAP Signalintensitäten wurden semiquantitativ ausgewertet und mit den Daten der neurokognitiven Test der HAND-1 Studie korreliert.
Egebnisse: Die GFAP-Autoantikörper Signalintensität unterscheidet sich je nach Gehirnareal (p < 0,0001). Insbesondere die DM-Signale sind signifikant stärker als die der anderen Areale (p < 0,01). Es lässt sich insgesamt kein signifikanter Unterschied in der Signalstärke zwischen Menschen mit HIV und Kontrollen feststellen (p = 0,1742). Bei der HIV-Gruppe zeigt das Gesamtergebnis des MMS einen signifikanten, negativen und starken Zusammenhang mit der GFAP- Antikörpersignalintensität der Areale DM (p = 0,004), ST (p = 0,011), MC (p = 0,007) und FC (p = 0,002). Es konnten keine signifikanten Korrelationen zwischen den CD4-Zellzahlen und den Anti-GFAP Signalintensitäten festgestellt werden. Bei der Kontrollgruppe fanden sich lediglich vereinzelt signifikante Korrelationen.
Diskussion: Diese Promotion ist die bis dato erste Veröffentlichung, in der GFAP-Autoantikörper bei Menschen mit HIV gemessen wurden. Dass kein Unterschied im Vorkommen von GFAP-Ak bei PLWH und der Kontrollgruppe gefunden wurde, könnte an der geringen Teilnehmendenzahl oder am Mangel von Teilnehmenden mit HAD liegen. Andererseits könnte es auch dafür sprechen, dass anti-GFAP nicht obligat pathogen ist, sondern erst nach Übertritt über die Blut-Hirn-Schranke pathologische Folgen hat. Für diese Hypothese spricht die Erkenntnis, dass eine höhere Menge von GFAP-Ak mit einem schlechteren Abschneiden bei neurokognitiven Tests korreliert. Demnach könnten sich GFAP-Autoantikörper als diagnostische und möglicherweise prognostische Marker eines neurokognitiven Defizites bei HAND eignen.
In der vorliegenden Arbeit wurden retrospektiv Daten von 321 Fällen eines fortgeschrit-
tenen Mammakarzinoms ausgewertet. Beobachtungsdaten lagen bis einschließlich Juli
1998 vor. Ein Fokus dieser Arbeit lag auf der Trichotomie der HER2-Ausprägung und
deren prognostischen Wert im Verlauf einer metastasierten Brustkrebserkrankung. In
einer neueren Entwicklung wurde HER2-low als Nomenklatur einer Subgruppe etabliert
für jene Mammakarzinome, die als IHC 1+ oder IHC 2+ gelten und ein negatives ISH-
Ergebnis aufweisen. Neue Studien-Ergebnisse zeigten einen signifikanten klinischen
Vorteil der Therapie mit HER2-basierten Antikörper-Wirkstoff-Konjugaten für HER2-low
Patientinnen (91).
Der Anteil der HER2-low Mammakarzinome nahm im Laufe einer fortgeschrittenen
Brustkrebserkrankung kontinuierlich zu und lag bei 39,3 % im Primärtumor, bei 47,7 %
im ersten Rezidiv und bei 47,8 % in einer zweiten Fernmetastase. Parallel vergrößerte
sich die HER2-positive Subgruppe, wobei sich die HER2-negative Kohorte folglich ver-
kleinerte. Es konnte entsprechend der aktuellen Literatur (117,156) eine Assoziation (p
< 0.001) des HER2-low Subtypen und HR-positiven Mammakarzinomen gezeigt werden.
HER2-low nahm in HR-positiven/Her2-negativen Mammakarzinomen im Laufe der Me-
tastasierung zu (56,7 % - 64,1 % - 75,6 %). Der Anteil der HER2-low-Expression im
Triple-negativen Subtypen initial bei 14,6 % und vergrößerte sich konstant (48,2 % - 50
%). Ein Verlust der HER2-Ausprägung im Krankheitsverlauf korrelierte statistisch signi-
fikant mit einem besseren OS (Hazards Ratio 0,533, 95%-KI[0,316, 0,898], p = .018).
Die Gruppe mit einer HER2-Konversion zu einer schwächeren Ausprägung wies im di-
rekten Vergleich zur Gruppe mit einer Her2-Konversion zu einer stärkeren Ausprägung
ein 21,0 Monate längeres Überleben auf (p = 0.177). Die Entwicklung eines HER2-posi-
tiven Primärtumor zu einer HER2-low Metastase (Hazards Ratio 0,385, 95%-KI[0,17,
0.874], p = .023), eine Veränderung von einem HER2-0 Primärtumor zu einer HER2-low
Metastase (Hazards Ratio 0,124, 95%-KI[0,023, 0,655], p = .014) sowie die ausblei-
bende Veränderung eines HER2-low Primärtumor zu einer Fernmetastase (Hazards Ra-
tio 0,169, 95%-KI[0,035, 0,813], p = .027) wurden in dieser Analyse als weitere protektive
Faktoren nachgewiesen. Kein klinisch-pathologischer oder therapeutischer Faktor
konnte als signifikanter Einflussfaktor auf eine Konversion im HER2-Rezeptor identifi-
ziert werden. Die Ergebnisse dieser Arbeit lassen keine klare Aussage darüber treffen,
ob die Anpassung der tumorspezifischen Therapie nach einer Rezeptorkonversion das
OS verbessert.
PA sind natürliche Pflanzeninhaltsstoffe, die wegen ihres genotoxischen Potentials bekannt sind. Nach Applikation mikromolarer Konzentrationen können bei in vitro Untersuchungen von Leberzellen chromosomale Schäden detektiert werden. PA stehen im Verdacht nach Aufnahme bei Menschen hepatotoxische und kanzerogene Wirkungen nach sich zu ziehen. In dieser Studie wurden Lasiocarpin und Riddelliin an der humanen Leberkarzinomzelllinie Huh6 auf Genotoxizität getestet. Die ausgewählten Methoden waren der MK-Test, der alkalische und der FPG Comet Assay und die γ-H2AX-Färbung. In den Vorversuchen mit BaP und CPA wurde gezeigt, dass die Zellen durch Prodrugs genotoxisch geschädigt werden. Zusammenfassend kann gesagt werden, dass Riddelliin und Lasiocarpin im MK-Test eine dosisabhängige, genotoxische Wirkung auf die Huh6 Zellen haben. Der Einfluss von Lasiocarpin war im MK-Test im Vergleich zum Einfluss von Riddelliin bei geringerer Konzentration detektierbar. Nach einer simultanen Behandlung der Huh6 Zellen mit verschiedenen PA kann konkludiert werden, dass keine signifikante Erhöhung an DNA-Schäden im Vergleich zu Behandlungen mit den Einzelsubstanzen festgestellt werden konnte, was möglicherweise auf eine Erschöpfung der metabolischen Kapazität der Zellen zurückzuführen ist. Insgesamt ist es den Ergebnissen zufolge wahrscheinlich, dass die Entstehung von Crosslinks durch Lasiocarpin und Riddelliin eher eine Rolle in der Genotoxizitätsinduktion auf Huh6 Zellen spielen als oxidativer Stress. Doppelstrangbrüche konnten nicht als sicherer Induktor von Genotoxizität identifiziert werden. Die Besonderheiten der Stoffwechselwege einzelner PA und die Spezifizierung einzelner, für die Metabolisierung relevanter Enzyme sollte in Zukunft Gegenstand der Forschung sein, um die kumulativen Wirkungen von PA besser nachzuvollziehen und die für den Menschen entstehenden Risiken durch die Aufnahme von PA konkretisieren zu können.
Bei der Atherosklerose handelt es sich um eine chronische inflammatorische Erkrankung, die sich an der arteriellen Gefäßinnenwand abspielt. Ihre Haupt-Manifestationsformen Schlaganfall und Herzinfarkt zählen zu den häufigsten Todesursachen weltweit. Eine chronische Endothelbelastung und -funktionsstörung, beeinflusst durch Risikofaktoren wie Diabetes, arterieller Bluthochdruck, Rauchen und Entzündungszustände, führen zur Permeabilitätserhöhung des Endothels, zur Zelleinwanderung, subendothelialen Lipidanreicherung, Migration glatter Muskelzellen und der Ausbildung atherosklerotischer Läsionen. Es kommt zu Aktivierung des Immunsystems und fortschreitender Entzündungsreaktion, schließlich zur Ausbildung eines nekrotischen Kerns und zunehmender Vulnerabilität des Plaques.
Epigenetische Veränderungen betreffen klassischerweise das Chromatingerüst. Durch DNA-Methylierung und -Demethylierung sowie verschiedene Modifikationen der Histon-Proteine kann die DNA in ihrer Zugänglichkeit verändert werden. So kann die Transkription eines bestimmten Genes direkt und potenziell längerfristig beeinflusst werden, ohne dass Alterationen der DNA-Basenfolge selbst stattfinden. Das Enzym SET7 nimmt hierbei eine Sonderrolle ein, da es neben einer Methylierung von Histon 3 auch verschiedene zelluläre Zielstrukturen posttranslational direkt methylieren kann.
Epigenetische Veränderungen im Kontext der Atherosklerose sind bereits vereinzelt beschrieben. Auch sind sie relevant in der Reaktion auf Umwelteinflüsse und bei inflammatorischen Vorgängen. Der Frage, ob epigenetische Mechanismen im atherosklerotischen Geschehen eine Rolle spielen, sollte in dieser Arbeit nachgegangen werden. Dazu wurde in Zellkulturversuchen für Makrophagen und glatte Muskelzellen geprüft, ob die einzelnen pro-atherosklerotischen Stimuli oxLDL, IL-1β, TNFα und LPS bereits zu relevanten Veränderungen epigenetischer Enzyme führen. Dies erfolgte über Vergleich der entsprechenden mRNA mittels qPCR. Zur Untersuchung der genaueren Dynamik wurde für die Enzyme SET7 und DNMT1 der zeitliche Ablauf dieser Reaktion auf TNFα-Stimulation in Makrophagen genauer betrachtet. Unter gleichen Versuchsbedingungen wurde außerdem die Änderung der mRNA-Expression einiger Matrixmetalloproteasen, TIMP-Enzyme, Zytokine und Transkriptionsfaktoren analysiert,um zukünftig kausale Zusammenhänge weiter aufdecken zu können. Auch die Frage nach Veränderungen epigenetischer Enzyme in der Ldlr-/--Maus nach fettreicher Diät im Vergleich zu Ldlr-/--Mäusen ohne Diät sollte hier beantwortet werden. Dazu wurde die mRNA der Zellsuspensionen aus Milz, Aortenwurzel und gesamter Aorta der Tiere mithilfe der qPCR verglichen. Schließlich sollte ein effizienter Weg für einen individuellen und flexiblen SET7 knock-out etabliert werden, um weitere Studien dieses Enzyms zu ermöglichen. Hierzu wurde die Methode des CRISPR/Cas9 Systems gewählt und abschließend die Funktionalität des Systems überprüft.
Trotz langjähriger klinischer Erfahrung, vielen Untersuchungen und Studien, ist die korrekte Diagnosestellung eines Morbus Menière immer noch schwierig. Diagnostische Mittel sind vor allem eine ausführliche Anamnese, die ECOG, Tonaudiogramm und der Ausschluss anderer Innenohrerkrankungen. Betroffene erleiden häufig Schwindelanfälle, Tinnitus, Ohrdruck und verlieren an Hörvermögen. Der progressive Verlauf dieser Erkrankung lässt sich meist nur verlangsamen. Häufig startet die Therapie funktionserhaltend-medikamentös mit Betahistin und Antiemetika, im weiteren Verlauf sind meist operative Eingriffe wie die Saccotomie nötig. Dabei wird der Saccus endolymphaticus aufgesucht, geschlitzt und mittels Silikondreieck offengehalten, um damit eine Entlastung des endolymphatischen Systems zu schaffen. Zeigt sich nur wenig Besserung kann destruierend fortgefahren werden. Hierbei sind vor allem die Gentamycin-Therapie und die Neurektomie oder Labyrinthektomie Mittel der Wahl.
Diese Untersuchung hatte das Ziel eine weitere diagnostische Methode zu finden, um die MM-Diagnose zu sichern und eine Prognose in Bezug auf die Therapie mittels Saccotomie zu liefern. Im Fokus stand hierbei der vestibuläre Aquädukt, welcher bereits in vielen Arbeiten auffällig in Form und Lage bei MM-Patienten gewesen war. Vor allem der Bezug des Aquäduktes zu den Bogengängen und dessen Länge wurden in der vorliegenden Studie genauer betrachtet. Dies geschah durch Messungen anhand von CT-Bildern. Der Winkel zwischen den Bogengängen und dem VA und die Länge des VA wurde gemessen und ausgewertet. Dies wurde zur Bestätigung der Methode, sowohl an menschlichen Felsenbeinpräparaten mit qualitativ unterschiedlichen CT-Aufnahmen als auch an Patienten durchgeführt. Dabei konnte man keine signifikanten Unterschiede innerhalb der verschiedenen CT-Aufnahmen der Felsenbeinpräparate feststellen.
Mit Bestätigung der Reliabilität dieser Methode wurden dann Patienten untersucht. Dabei wurden zwei Gruppen gebildet, Nicht-MM- und MM-Patienten. Die Nicht-MM bestanden aus Patienten mit einem Akustikusneurinom der Gegenseite oder einem Cochlea-Implantat, welche keinen MM aufwiesen. Die MM-Patienten wurden alle mit einer Saccotomie behandelt und hatten damit einen gesicherten MM. Die Auswertung der Messergebnisse stellte dar, dass bei MM-Betroffenen die Länge mit durchschnittlich 7,9 mm im Vergleich mit Nicht-Betroffenen-VA (9,5 mm), signifikant reduziert war. Auch die Ergebnisse der Winkelmessung zeigte bei allen Bogengängen signifikante Unterschiede.
Um die Ergebnisse der Winkelmessung besser zu kategorisieren, wurde der VA-Score erstellt. Dieser vereinigt die Ergebnisse der drei Bogengänge zu einem Wert von 1 bis 8. Auch hier erwiesen sich die MM-Patienten als auffällig, da sich diese im VA-Score 2 mit 44% häuften. Im Gegensatz dazu waren die Ergebnisse der nicht Erkrankten breiter verteilt.
Zur weiteren Auswertung zählten außerdem die anamnestischen Daten und der Verlauf der Saccotomie. Dadurch konnte der Erfolg der Behandlung bestimmt und diese mit den Untersuchungen des VA des jeweiligen Patienten korreliert werden. Dabei stellte sich heraus, dass vor allem bei VA mit hohen Winkeln und sehr kurzen VA die Erfolgsquote geringer war.
Damit könnte also ein Zusammenhang zwischen Form und Lage des VA und Therapie bestehen. Um dies sicher zu bestätigen, braucht es noch mehr Patienten und eine klinisch zugelassene Software, die diese Messungen durchführen kann. Hierbei ist vor allem eine gute Bildgebung des Innenohrs wichtig, um den VA optimal messen zu können. Um die Messungen schnell und zuverlässig durchführen zu können, wäre eine Software, welche die Messungen automatisch durchführen kann, ein möglicher Ansatz. Die ausführliche Voruntersuchung wird jedoch weiterhin notwendig sein, um MM sicher zu diagnostizieren.
Die vorliegende Arbeit nimmt das sprachliche Phänomen Unterbrechung in Gesprächssituationen und seine Realisation in authentischen Gesprächen der drei Gesprächssorten Polittalk, Tischgespräch und Studienberatungsgespräch in den Blick. Unterbrechungen werden dabei in Auseinandersetzung mit der Forschungsliteratur als eine spezifische Form des Sprecherwechsels in Gesprächen von anderen Sprecherwechselformen abgegrenzt. Die Analyse kann 22 Typen von Unterbrechungen strukturell und quantitativ differenzieren und in einem Schema voneinander abgrenzen. Diese Typen werden mit Korpusbeispielen belegt. Es kann gezeigt werden, dass die Verteilung der unterschiedlichen Typen von Unterbrechungen in unterschiedlichen Gesprächssorten variiert. Dieser Befund lässt Rückschüsse auf unterschiedliche Faktoren und Funktionen der einzelnen Typen zu.
Wo etwas Verborgenes, das vom öffentlichen Diskurs ausgeschlossen wurde, plötzlich sichtbar wird, ereignen sich Offenbarungen. Wenn es dabei um Menschenrechte geht, so entsteht ein prekärer Augenblick, der große Chancen und zugleich unübersehbare Risiken birgt. Verworfenes Leben kann sich Bahn brechen; oder es wird durch schmerzliche Vulneranz erneut verfemt und zerstört. In Verwundungen, die an der Schwelle des UnSichtbaren geschehen, tritt die Vulnerabilität der Menschenrechte hervor.
Das vorliegende Buch erscheint 2023 und damit 75 Jahre nach der "Allgemeinen Erklärung der Menschenrechte" der Vereinten Nationen. Menschenrechte sind eine gegen viele Widerstände und mit großen Opfern durchgesetzte Errungenschaft der Menschheit. Heute werden sie erneut zu einem verletzten und verletzbaren Gut.
Daher analysiert das Buch die ambivalente Macht der Vulnerabilität an signifi kanten Diskursorten der Gegenwart; es legt die Vulneranz der katholischen Kirche bezüglich Missbrauch, Vertuschung und Gendertrouble frei; und es fragt nach der offenbarenden Kraft an jener Schwelle, wo die Menschenrechte in Gefahr sind.
Mit Beiträgen von Prof. Dr. Stephan Lessenich, Dr. Sabine Bauer-Amin, Florian Pistrol, Steven Höfner, Prof. Dr. Ute Leimgruber, Prof. Dr. Hildegund Keul, Dr. Andreas Heek, Prof. Dr. Peter G. Kirchschläger, Dr. Jutta Czapski, Prof. Dr. Ansgar Kreutzer.
Universal prevention for non-suicidal self-injury in adolescents is scarce - A systematic review
(2023)
Non-suicidal self-injury (NSSI) during adolescence is a high-risk marker for the development and persistence of mental health problems and has been recognized as a significant public health problem. Whereas targeted prevention has indeed shown to be effective in reducing NSSI and improve mental health problems, access to such programs is limited. By face validity, universal prevention of NSSI seems an ideal starting point for a stepped-care model to circumvent a lack of resources in the medical care system. However, it is yet unclear how effective such approaches are. Here, we provide a summary of existing work on universal prevention of NSSI in adolescents younger than 21 years based on a systematic literature search. We found that only seven studies are available. None of the programs evaluated was found to be effective in reducing the incidence or frequency of NSSI. After providing a comprehensive summary of the existing work, we evaluate the fact that existing work primarily focusses on selected/targeted prevention and on psychoeducational methods. We derive implications for future directions in the field of universal prevention of NSSI.
There is great interest in affordable, precise and reliable metrology underwater:
Archaeologists want to document artifacts in situ with high detail.
In marine research, biologists require the tools to monitor coral growth and geologists need recordings to model sediment transport.
Furthermore, for offshore construction projects, maintenance and inspection millimeter-accurate measurements of defects and offshore structures are essential.
While the process of digitizing individual objects and complete sites on land is well understood and standard methods, such as Structure from Motion or terrestrial laser scanning, are regularly applied, precise underwater surveying with high resolution is still a complex and difficult task.
Applying optical scanning techniques in water is challenging due to reduced visibility caused by turbidity and light absorption.
However, optical underwater scanners provide significant advantages in terms of achievable resolution and accuracy compared to acoustic systems.
This thesis proposes an underwater laser scanning system and the algorithms for creating dense and accurate 3D scans in water.
It is based on laser triangulation and the main optical components are an underwater camera and a cross-line laser projector.
The prototype is configured with a motorized yaw axis for capturing scans from a tripod.
Alternatively, it is mounted to a moving platform for mobile mapping.
The main focus lies on the refractive calibration of the underwater camera and laser projector, the image processing and 3D reconstruction.
For highest accuracy, the refraction at the individual media interfaces must be taken into account.
This is addressed by an optimization-based calibration framework using a physical-geometric camera model derived from an analytical formulation of a ray-tracing projection model.
In addition to scanning underwater structures, this work presents the 3D acquisition of semi-submerged structures and the correction of refraction effects.
As in-situ calibration in water is complex and time-consuming, the challenge of transferring an in-air scanner calibration to water without re-calibration is investigated, as well as self-calibration techniques for structured light.
The system was successfully deployed in various configurations for both static scanning and mobile mapping.
An evaluation of the calibration and 3D reconstruction using reference objects and a comparison of free-form surfaces in clear water demonstrate the high accuracy potential in the range of one millimeter to less than one centimeter, depending on the measurement distance.
Mobile underwater mapping and motion compensation based on visual-inertial odometry is demonstrated using a new optical underwater scanner based on fringe projection.
Continuous registration of individual scans allows the acquisition of 3D models from an underwater vehicle.
RGB images captured in parallel are used to create 3D point clouds of underwater scenes in full color.
3D maps are useful to the operator during the remote control of underwater vehicles and provide the building blocks to enable offshore inspection and surveying tasks.
The advancing automation of the measurement technology will allow non-experts to use it, significantly reduce acquisition time and increase accuracy, making underwater metrology more cost-effective.
Three-dimensional capturing of underwater archeological sites or sunken shipwrecks can support important documentation purposes. In this study, a novel 3D scanning system based on structured illumination is introduced, which supports cultural heritage documentation and measurement tasks in underwater environments. The newly developed system consists of two monochrome measurement cameras, a projection unit that produces aperiodic sinusoidal fringe patterns, two flashlights, a color camera, an inertial measurement unit (IMU), and an electronic control box. The opportunities and limitations of the measurement principles of the 3D scanning system are discussed and compared to other 3D recording methods such as laser scanning, ultrasound, and photogrammetry, in the context of underwater applications. Some possible operational scenarios concerning cultural heritage documentation are introduced and discussed. A report on application activities in water basins and offshore environments including measurement examples and results of the accuracy measurements is given. The study shows that the new 3D scanning system can be used for both the topographic documentation of underwater sites and to generate detailed true-scale 3D models including the texture and color information of objects that must remain under water.
Aggression and deficient cognitive control problems are widespread in psychiatric disorders, including major depressive disorder (MDD). These abnormalities are known to contribute significantly to the accompanying functional impairment and the global burden of disease. Progress in the development of targeted treatments of excessive aggression and accompanying symptoms has been limited, and there exists a major unmet need to develop more efficacious treatments for depressed patients. Due to the complex nature and the clinical heterogeneity of MDD and the lack of precise knowledge regarding its pathophysiology, effective management is challenging. Nonetheless, the aetiology and pathophysiology of MDD has been the subject of extensive research and there is a vast body of the latest literature that points to new mechanisms for this disorder. Here, we overview the key mechanisms, which include neuroinflammation, oxidative stress, insulin receptor signalling and abnormal myelination. We discuss the hypotheses that have been proposed to unify these processes, as many of these pathways are integrated for the neurobiology of MDD. We also describe the current translational approaches in modelling depression, including the recent advances in stress models of MDD, and emerging novel therapies, including novel approaches to management of excessive aggression, such as anti-diabetic drugs, antioxidant treatment and herbal compositions.
Understanding the Performance of Different Packet Reception and Timestamping Methods in Linux
(2023)
This document briefly presents some renowned packet reception techniques for network packets in Linux systems. Further, it compares their performance when measuring packet timestamps with respect to throughput and accuracy. Both software and hardware timestamps are compared, and various parameters are examined, including frame size, link speed, network interface card, and CPU load. The results indicate that hardware timestamping offers significantly better accuracy with no downsides, and that packet reception techniques that avoid system calls offer superior measurement throughput.
Humans spontaneously blink several times a minute. These blinks are strongly modulated during various cognitive task. However, the precise function of blinking and the reason for their modulation has not been fully understood. In the present work, I investigated the function of spontaneous blinks through various perceptual and cognitive tasks. Previous research has revealed that blinks rates decrease during some tasks but increase during others. When trying to understand these seemingly contradictory results, I observed that blink reduction occurs when one engages with an external input. For instance, a decrease has been observed due to the onset of a stimulus, sensory input processing and attention towards sensory input. However, for activities that do not involve such an engagement, e.g. imagination, daydreaming or creativity, the blink rate has been shown to increase. To follow up on the proposed hypothesis, I distinguished tasks that involve the processing of an external stimulus and tasks that involve disengagement.
In the first part of the project, I explored blinking during stimulus engagement. If the probability of blinking is low when engaging with the stimulus, then one should find a reduction in blinks specifically during the time period of processing but not during sensory input per se. To this end, in study 1, I tested the influence of task-relevant information duration on blink timing and additionally manipulated the overall sensory input using a visual and an auditory temporal simultaneity judgement task. The results showed that blinks were suppressed longer for longer periods of relevant information or in other words, blinks occurred at the end of relevant information processing for both the visual and the auditory modality. Since relevance is mediated through top-down processes, I argue that the reduction in blinks is a top-down driven suppression. In studies 2 and 3, I again investigated stimulus processing, but in this case, processing was triggered internally and not based on specific changes in the external input. To this end, I used bistable stimuli, in which the actual physical stimulus remains constant but their perception switches between different interpretations. Studies on the involvement of attention in such bistable perceptual changes indicate that the sensory input is reprocessed before the perceptual switch. The results revealed a reduction in eye blink rates before the report of perceptual switches. Importantly, I was able to decipher that the decrease was not caused by the perceptual switch or the behavioral response but likely started before the internal switch. Additionally, periods between a blink and a switch were longer than interblink intervals, indicating that blinks were followed by a period of stable percept. To conclude, the first part of the project revealed that there is a top-down driven blink suppression during the processing of an external stimulus.
In the second part of the project, I extended the idea of blinks marking the disengagement from external processing and tested if blinking is associated with better performance during internally directed processes. Specifically, I investigated divergent thinking, an aspect of creativity, and the link between performance and blink rates as well as the effect of motor restriction. While I could show that motor restriction was the main factor influencing divergent thinking, the relationship between eye blink rates and creative output also depended on restriction. Results showed that higher blink rates were associated with better performance during free movement, but only between subjects. In other words, subjects who had overall higher blink rates scored better in the task, but when they were allowed to sit or walk freely. Within a single subject, trial with higher blink rates were not associated with better performance. Therefore, possibly, people who are able to disengage easily, as indicated by an overall high blink rate, perform better in divergent thinking tasks. However, the link between blink rate and internal tasks is not clear at this point. Indeed, a more complex measurement of blink behavior might be necessary to understand the relationship.
In the final part of the project, I aimed to further understand the function of blinks through their neural correlates. I extracted the blink-related neural activity in the primary visual cortex (V1) of existing recordings of three rhesus monkeys during different sensory processing states. I analyzed spike related multi-unit responses, frequency dependent power changes, local field potentials and laminar distribution of activity while the animal watched a movie compared to when it was shown a blank screen. The results showed a difference in blink-related neural activity dependent on the processing state. This difference suggests a state dependent function of blinks.
Taken altogether, the work presented in this thesis suggests that eye blinks have an important function during cognitive and perceptual processes. Blinks seem to facilitate a disengagement from the external world and are therefore suppressed during intended processing of external stimuli.
Ubiquitylation is a protein post translational modification, in which ubiquitin is covalently attached to target protein substrates resulting in diverse cellular outcomes. Besides ubiquitin, various ubiquitin-like proteins including FAT10 exist, which are also conjugated to target proteins. The underlying modification mechanisms are conserved. In the initial step, ubiquitin or a ubiquitin-like protein is thioester-linked to a catalytic cysteine in the E1activating enzyme in an ATP-dependent manner. The respective protein modifier is then transferred to an E2 conjugating enzyme in a transthioesterification reaction. Finally, an E3 ubiquitin ligase E3 catalyzes the covalent attachment of the protein modifier to a substrate. In the case of ubiquitin, multiple ubiquitin molecules can be attached to a substrate in the form of either linear or branched polyubiquitin chains but also as single ubiquitin modifications. Depending on the nature of the ubiquitin chain, the substrates are destined to various cellular processes such as their targeted destruction by the proteasome but also non-degradative outcomes may occur.
As stated above FAT10 is a ubiquitin-like protein modifier which typically targets proteins for proteasomal degradation. It consists of two ubiquitin-like domains and is mainly expressed in cells of the human immune system. The reported involvement of FAT10 modifications in cancers and other diseases has caught the attention of the scientific community as an inhibition of the FAT10ylation process may provide avenues for novel therapeutic approaches. UBA6 is the E1 activating enzyme that resides at the apex of the FAT10 proteasomal degradation pathway. UBA6 not only recognizes FAT10 but can also activate ubiquitin as efficiently as the ubiquitin specific E1 UBA1. The dual specificity of UBA6 may complicate the inhibition FAT10ylation since targeting the active site of UBA6 will also inhibit the UBA6-catalyzed ubiquitin activation. Therefore, it is important to understand the underlying principles for the dual specificity of UBA6 prior to the development of compounds interfering with FAT10ylation.
In this thesis important novel insights into the structure and function of UBA6 were derived by X-ray crystallography and biochemical methods. The first crystal structure of UBA6 reveals the multidomain architecture of this enzyme in atomic detail. The enzyme is composed of a rigid core including its active and inactive adenylation domains as well as a 4 helix bundle. Overall, the molecule adopts a “Y” shape architecture with the core at the base and the first and second catalytic half domains forming one arm of the “Y” and the ubiquitin fold domain constituting the other arm. While UBA6 shares the same domain architecture as UBA1, substantial differences were revealed by the crystal structure. In particular, the first catalytic half domain undergoes a significant shift to a position more distal from the core. This rigid body movement is assumed to generate room to accommodate the second ubiquitin-like domain of FAT10. Differences are also observed in a hydrophobic platform between the core and the first catalytic half domain and the adenylation active site in the core, which together from the binding sites for ubiquitin and FAT10. Site directed mutagenesis of key residues in these areas altered the UBA6-catalyzed activation of ubiquitin and FAT10. UBA6 variants were generated with the goal of trying to block the activation of FAT10 while still maintaining that of ubiquitin activation, in order to fully explain the dual specificity of UBA6. However, none of these mutations could block the activation of FAT10, while some of these UBA6 variants blocked ubiquitin activation. Preliminary inhibition assays with a group of E1 inhibitors belonging to the adenosyl sulfamate family demonstrated potent inhibition of FAT10ylation for two compounds. The dual specificity of UBA6 hence needs to be further examined by biochemical and structural methods. In particular, the structure of a complex between UBA6 and ubiquitin or FAT10 would provide key insights for further biochemical studies, ultimately allowing the targeted inhibition of the FAT10ylation machinery.
In this study, the impact of reconstruction sharpness on the visualization of the appendicular skeleton in ultrahigh-resolution (UHR) photon-counting detector (PCD) CT was investigated. Sixteen cadaveric extremities (eight fractured) were examined with a standardized 120 kVp scan protocol (CTDI\(_{vol}\) 10 mGy). Images were reconstructed with the sharpest non-UHR kernel (Br76) and all available UHR kernels (Br80 to Br96). Seven radiologists evaluated image quality and fracture assessability. Interrater agreement was assessed with the intraclass correlation coefficient. For quantitative comparisons, signal-to-noise-ratios (SNRs) were calculated. Subjective image quality was best for Br84 (median 1, interquartile range 1–3; p ≤ 0.003). Regarding fracture assessability, no significant difference was ascertained between Br76, Br80 and Br84 (p > 0.999), with inferior ratings for all sharper kernels (p < 0.001). Interrater agreement for image quality (0.795, 0.732–0.848; p < 0.001) and fracture assessability (0.880; 0.842–0.911; p < 0.001) was good. SNR was highest for Br76 (3.4, 3.0–3.9) with no significant difference to Br80 and Br84 (p > 0.999). Br76 and Br80 produced higher SNRs than all kernels sharper than Br84 (p ≤ 0.026). In conclusion, PCD-CT reconstructions with a moderate UHR kernel offer superior image quality for visualizing the appendicular skeleton. Fracture assessability benefits from sharp non-UHR and moderate UHR kernels, while ultra-sharp reconstructions incur augmented image noise.
Ultra-high-resolution photon-counting detector CT arthrography of the ankle: a feasibility study
(2023)
This study was designed to investigate the image quality of ultra-high-resolution ankle arthrography employing a photon-counting detector CT. Bilateral arthrograms were acquired in four cadaveric specimens with full-dose (10 mGy) and low-dose (3 mGy) scan protocols. Three convolution kernels with different spatial frequencies were utilized for image reconstruction (ρ\(_{50}\); Br98: 39.0, Br84: 22.6, Br76: 16.5 lp/cm). Seven radiologists subjectively assessed the image quality regarding the depiction of bone, hyaline cartilage, and ligaments. An additional quantitative assessment comprised the measurement of noise and the computation of contrast-to-noise ratios (CNR). While an optimal depiction of bone tissue was achieved with the ultra-sharp Br98 kernel (S ≤ 0.043), the visualization of cartilage improved with lower modulation transfer functions at each dose level (p ≤ 0.014). The interrater reliability ranged from good to excellent for all assessed tissues (intraclass correlation coefficient ≥ 0.805). The noise levels in subcutaneous fat decreased with reduced spatial frequency (p < 0.001). Notably, the low-dose Br76 matched the CNR of the full-dose Br84 (p 0.999) and superseded Br98 (p < 0.001) in all tissues. Based on the reported results, a photon-counting detector CT arthrography of the ankle with an ultra-high-resolution collimation offers stellar image quality and tissue assessability, improving the evaluation of miniscule anatomical structures. While bone depiction was superior in combination with an ultra-sharp convolution kernel, soft tissue evaluation benefited from employing a lower spatial frequency.
Ultra-high field cardiac MRI in large animals and humans for translational cardiovascular research
(2023)
A key step in translational cardiovascular research is the use of large animal models to better understand normal and abnormal physiology, to test drugs or interventions, or to perform studies which would be considered unethical in human subjects. Ultrahigh field magnetic resonance imaging (UHF-MRI) at 7 T field strength is becoming increasingly available for imaging of the heart and, when compared to clinically established field strengths, promises better image quality and image information content, more precise functional analysis, potentially new image contrasts, and as all in-vivo imaging techniques, a reduction of the number of animals per study because of the possibility to scan every animal repeatedly. We present here a solution to the dual use problem of whole-body UHF-MRI systems, which are typically installed in clinical environments, to both UHF-MRI in large animals and humans. Moreover, we provide evidence that in such a research infrastructure UHF-MRI, and ideally combined with a standard small-bore UHF-MRI system, can contribute to a variety of spatial scales in translational cardiovascular research: from cardiac organoids, Zebra fish and rodent hearts to large animal models such as pigs and humans. We present pilot data from serial CINE, late gadolinium enhancement, and susceptibility weighted UHF-MRI in a myocardial infarction model over eight weeks. In 14 pigs which were delivered from a breeding facility in a national SARS-CoV-2 hotspot, we found no infection in the incoming pigs. Human scanning using CINE and phase contrast flow measurements provided good image quality of the left and right ventricle. Agreement of functional analysis between CINE and phase contrast MRI was excellent. MRI in arrested hearts or excised vascular tissue for MRI-based histologic imaging, structural imaging of myofiber and vascular smooth muscle cell architecture using high-resolution diffusion tensor imaging, and UHF-MRI for monitoring free radicals as a surrogate for MRI of reactive oxygen species in studies of oxidative stress are demonstrated. We conclude that UHF-MRI has the potential to become an important precision imaging modality in translational cardiovascular research.
Explaining the baryon asymmetry of the Universe has been a long-standing problem of particle physics, with the consensus being that new physics is required as the Standard Model (SM) cannot resolve this issue. Beyond the Standard Model (BSM) scenarios would need to incorporate new sources of \(CP\) violation and either introduce new departures from thermal equilibrium or modify the existing electroweak phase transition. In this thesis, we explore two approaches to baryogenesis, i.e. the generation of this asymmetry.
In the first approach, we study the two-particle irreducible (2PI) formalism as a means to investigate non-equilibrium phenomena. After arriving at the renormalised equations of motions (EOMs) to describe the dynamics of a phase transition, we discuss the techniques required to obtain the various counterterms in an on-shell scheme. To this end, we consider three truncations up to two-loop order of the 2PI effective action: the Hartree approximation, the scalar sunset approximation and the fermionic sunset approximation. We then reconsider the renormalisation procedure in an \(\overline{\text{MS}}\) scheme to evaluate the 2PI effective potential for the aforementioned truncations. In the Hartree and the scalar sunset approximations, we obtain analytic expressions for the various counterterms and subsequently calculate the effective potential by piecing together the finite contributions. For the fermionic sunset approximation, we obtain similar equations for the counterterms in terms of divergent parts of loop integrals. However, these integrals cannot be expressed in an analytic form, making it impossible to evaluate the 2PI effective potential with the fermionic contribution. Our main results are thus related to the renormalisation programme in the 2PI formalism: \( (i) \)the procedure to obtain the renormalised EOMs, now including fermions, which serve as the starting point for the transport equations for electroweak baryogenesis and \( (ii) \) the method to obtain the 2PI effective potential in a transparent manner.
In the second approach, we study baryogenesis via leptogenesis. Here, an asymmetry in the lepton sector is generated, which is then converted into the baryon asymmetry via the sphaleron process in the SM. We proceed to consider an extension of the SM along the lines of a scotogenic framework. The newly introduced particles are charged odd under a \(\mathbb{Z}_2\) symmetry, and masses for the SM neutrinos are generated radiatively. The \(\mathbb{Z}_2\) symmetry results in the lightest BSM particle being stable, allowing for a suitable dark matter (DM) candidate. Furthermore, the newly introduced heavy Majorana fermionic singlets provide the necessary sources of \(CP\) violation through their Yukawa interactions and their out-of-equilibrium decays produce a lepton asymmetry. This model is constrained from a wide range of observables, such as consistency with neutrino oscillation data, limits on branching ratios of charged lepton flavour violating decays, electroweak observables and obtaining the observed DM relic density. We study leptogenesis in this model in light of the results of a Markov chain Monte Carlo scan, implemented in consideration of the aforementioned constraints. Successful leptogenesis in this model, to account for the baryon asymmetry, then severely constrains the available parameter space.
The chirality of the interlocked bay-arylated perylene motif is investigated upon its material prospect and the enhancement of its chiroptical response to the NIR spectral region. A considerable molecular library of inherently chiral perylene bisimides (PBIs) was utilized as acceptors in organic solar cells to provide decent device performances and insights into the structure-property relationship of PBI materials within a polymer blend. For the first time in the family of core-twisted PBIs, the effects of enantiopurity on the device performance was thoroughly investigated. The extraordinary structural sensitivity of CD spectroscopy served as crucial analytical tool to bridge the highly challenging gap between molecular properties and device analytics by proving the excitonic chirality of a helical PBI dimer. The chirality of this perylene motif could be further enhanced on a molecular level by both the expansion and the enhanced twisting of the π-scaffold to achieve a desirable strong chiroptical NIR response introducing a new family of twisted QBI-based nanoribbons. These achievements could be substantially further developed by expanding this molecular concept to a supramolecular level. The geometrically demanding supramolecular arrangement necessary for the efficient excitonic coupling was carefully encoded into the molecular design. Accordingly, the QBIs could form the first J-type aggregate constituting a fourfold-stranded superhelix of a rylene bisimide with strong excitonic chirality. Therefore, this thesis has highlighted the mutual corroboration of experimental and theoretical data from the molecular to the supramolecular level. It has demonstrated that for rylene bisimide dyes, the excitonic contribution to the overall chiroptical response can be designed and rationalized. This can help to pave the way for new organic functional materials to be used for
chiral sensing or chiral organic light-emitting devices.
Immune checkpoint blockade therapy is beneficial and even curative for some cancer patients. However, the majority don’t respond to immune therapy. Across different tumor types, pre-existing T cell infiltrates predict response to checkpoint-based immunotherapy. Based on in vitro pharmacological studies, mouse models and analyses of human melanoma patients, we show that the cytokine GDF-15 impairs LFA-1/β2-integrin-mediated adhesion of T cells to activated endothelial cells, which is a pre-requisite of T cell extravasation. In melanoma patients, GDF-15 serum levels strongly correlate with failure of PD-1-based immune checkpoint blockade therapy. Neutralization of GDF-15 improves both T cell trafficking and therapy efficiency in murine tumor models. Thus GDF-15, beside its known role in cancer-related anorexia and cachexia, emerges as a regulator of T cell extravasation into the tumor microenvironment, which provides an even stronger rationale for therapeutic anti-GDF-15 antibody development.
Non-small cell lung cancer, ovarian cancer, and pancreatic cancer all present with high morbidity and mortality. Systemic chemotherapies have historically been the cornerstone of standard of care (SOC) regimens for many cancers, but are associated with systemic toxicity. Multimodal treatment combinations can help improve patient outcomes; however, implementation is limited by additive toxicities and potential drug–drug interactions. As such, there is a high unmet need to develop additional therapies to enhance the efficacy of SOC treatments without increasing toxicity. Tumor Treating Fields (TTFields) are electric fields that exert physical forces to disrupt cellular processes critical for cancer cell viability and tumor progression. The therapy is locoregional and is delivered noninvasively to the tumor site via a portable medical device that consists of field generator and arrays that are placed on the patient’s skin. As a noninvasive treatment modality, TTFields therapy-related adverse events mainly consist of localized skin reactions, which are manageable with effective acute and prophylactic treatments. TTFields selectively target cancer cells through a multi-mechanistic approach without affecting healthy cells and tissues. Therefore, the application of TTFields therapy concomitant with other cancer treatments may lead to enhanced efficacy, with low risk of further systemic toxicity. In this review, we explore TTFields therapy concomitant with taxanes in both preclinical and clinical settings. The summarized data suggest that TTFields therapy concomitant with taxanes may be beneficial in the treatment of certain cancers.
In a recent study, we showed in an in vitro murine cerebellar microvascular endothelial cell (cerebEND) model as well as in vivo in rats that Tumor-Treating Fields (TTFields) reversibly open the blood–brain barrier (BBB). This process is facilitated by delocalizing tight junction proteins such as claudin-5 from the membrane to the cytoplasm. In investigating the possibility that the same effects could be observed in human-derived cells, a 3D co-culture model of the BBB was established consisting of primary microvascular brain endothelial cells (HBMVEC) and immortalized pericytes, both of human origin. The TTFields at a frequency of 100 kHz administered for 72 h increased the permeability of our human-derived BBB model. The integrity of the BBB had already recovered 48 h post-TTFields, which is earlier than that observed in cerebEND. The data presented herein validate the previously observed effects of TTFields in murine models. Moreover, due to the fact that human cell-based in vitro models more closely resemble patient-derived entities, our findings are highly relevant for pre-clinical studies.
Im Rahmen dieser Arbeit wurde die Reaktivität des Phosphorans (C2F5)3PF2 gegenüber Lewis-Basen (N-heterozyklische Carbene und Phosphane) und gegenüber verschiedenen Übergangsmetall-Fluoridokomplexen untersucht. Im ersten Teil werden die Lewis-Säure/Base-Addukte zwischen (C2F5)3PF2 und verschiedenen
N-heterozyklischen Carbenen (NHCs) beschrieben. Der Fokus des zweiten Teils der Arbeit liegt auf der Darstellung kationischer Komplexe ausgehend von neutralen d-Block-Metallfluoriden, welche durch Fluorid-Transfer auf das Lewis-acide (C2F5)3PF2 erfolgt. Hierbei wurden Komplexe verschiedener Übergangsmetalle (Ti, Ni, Cu) verwendet, wodurch der Fluorid-Transfer auf das Phosphoran quer über die 3d-Reihe untersucht wurde. Im letzten Kapitel dieser Arbeit wurden die Synthese und die Anwendung von Kationen des Typs [(NHC)Cu]+ eingehender untersucht. Dazu wurde zunächst die Synthese der Ausgangsverbindungen [(NHC)Cu(F)] modifiziert. Anschließend wurden diese Fluorido-Komplexe auf deren Reaktivität gegenüber (C2F5)3PF2 untersucht. Nachfolgend wurden die Reaktivität von [(Dipp2Im)Cu(C6Me6)]FAP in Ligandenaustauschreaktionen bzw. die Synthese von Komplexen [(Dipp2Im)Cu(LB)]FAP (LB = Lewis-Base) eingehender untersucht.
The great progress in organic photovoltaics (OPV) over the past few years has been largely achieved by the development of non‐fullerene acceptors (NFAs), with power conversion efficiencies now approaching 20%. To further improve device performance, loss mechanisms must be identified and minimized. Triplet states are known to adversely affect device performance, since they can form energetically trapped excitons on low‐lying states that are responsible for non‐radiative losses or even device degradation. Halogenation of OPV materials has long been employed to tailor energy levels and to enhance open circuit voltage. Yet, the influence on recombination to triplet excitons has been largely unexplored. Using the complementary spin‐sensitive methods of photoluminescence detected magnetic resonance and transient electron paramagnetic resonance corroborated by transient absorption and quantum‐chemical calculations, exciton pathways in OPV blends are unravelled employing the polymer donors PBDB‐T, PM6, and PM7 together with NFAs Y6 and Y7. All blends reveal triplet excitons on the NFA populated via non‐geminate hole back transfer and, in blends with halogenated donors, also by spin‐orbit coupling driven intersystem crossing. Identifying these triplet formation pathways in all tested solar cell absorber films highlights the untapped potential for improved charge generation to further increase plateauing OPV efficiencies.
Alignment strategies for primary total knee arthroplasty (TKA) have changed significantly over time with a shift towards a more individualized alignment goal. At the same time, computer-assisted surgery (CAS) has gained interest for intraoperative control and accuracy in implant positioning and limb alignment. Despite the often discussed benefits and drawbacks of robotics and navigation for TKA, the routine use of these new devices on a day-to-day basis remains obscure. Therefore, nationwide hospital billing data based on the Operation Procedure Classification System (OPS) were retrieved from the Federal Statistical Office of Germany for the period from 2010 to 2021. OPS codes for primary total knee arthroplasty (OPS code: 5-822*) were further analyzed regarding the usage of computer navigation (additional OPS code: 5-988) or robotic devices (additional OPS code: 5-987). Gender and age at the time of surgery were also assessed. The results show a total of 2,226,559 primary TKAs were implanted between 2010 and 2021, of which 2,044,914 were performed conventionally (91.84% of all TKAs). A total of 170,276 TKAs were performed using navigation technique (7.65% of all TKAs) and another 11,369 TKAs were performed using robotics (0.51% of all TKAs). For the period from 2018 to 2021, a substantial increase in robot-assisted TKA (R-TKA) was observed, with an average increase rate of 84.74% per year, while the number of navigated TKAs declined (−3.67% per year). Computer-assisted surgery, and particularly robotics for TKA, are seeing growing popularity and stepwise translation into routine clinical use in Germany, with a steep increase rate of more than 80% per year since 2018. Nevertheless, the majority of TKAs are still performed using manual instrumentation, rendering conventional TKA the currently unchanged gold standard.
Treating seronegative neuromyelitis optica spectrum disorder with inebilizumab: a case report
(2023)
Background
Neuromyelitis optica spectrum disorder (NMOSD) is a devastating inflammatory disease of the central nervous system that is often severely disabling from the outset. The lack of pathognomonic aquaporin 4 (AQP4) antibodies in seronegative NMOSD not only hinders early diagnosis, but also limits therapeutic options, in contrast to AQP4 antibody-positive NMOSD, where the therapeutic landscape has recently evolved massively.
Case presentation
We report a 56-year-old woman with bilateral optic neuritis and longitudinally extensive myelitis as the index events of a seronegative NMOSD, who was successfully treated with inebilizumab.
Conclusion
Treatment with inebilizumab may be considered in aggressive seronegative NMOSD. Whether broader CD19-directed B cell depletion is more effective than treatment with rituximab remains elusive.
The fact that photovoltaics is a key technology for climate-neutral energy production can be taken as a given. The question to what extent perovskite will be used for photovoltaic technologies has not yet been fully answered. From a photophysical point of view, however, it has the potential to make a useful contribution to the energy sector. However, it remains to be seen whether perovskite-based modules will be able to compete with established technologies in terms of durability and cost efficiency. The additional aspect of ionic migration poses an additional challenge. In the present work, primarily the interaction between ionic redistribution, capacitive properties and recombination dynamics was investigated. This was done using impedance spectroscopy, OCVD and IV characteristics as well as extensive numerical drift-diffusion simulations. The combination of experimental and numerical methods proved to be very fruitful. A suitable model for the description of solar cells with respect to mobile ions was introduced in chapter 4.4. The formal mathematical description of the model was transferred by a non-dimensionalization and suitable numerically solvable form. The implementation took place in the Julia language. By intelligent use of structural properties of the sparse systems of equations, automatic differentiation and the use of efficient integration methods, the simulation tool is not only remarkably fast in finding the solution, but also scales quasi-linearly with the grid resolution. The software package was released under an open source license. In conventional semiconductor diodes, capacitance measurements are often used to determine the space charge density. In the first experimental chapter 5, it is shown that although this is also possible for the ionic migration present in perovskites, it cannot be directly understood as doping related, since the space charge distribution strongly depends on the preconditions and can be manipulated by an externally applied voltage. The exact form of this behavior depends on the perovskite composition. This shows, among other things, that experimental results can only be interpreted within the framework of conventional semiconductors to a very limited extent. Nevertheless, the built-in 99 potential of the solar cell can be determined if the experiments are carried out properly. A statement concerning the type and charge of the mobile ions is not possible without further effort, while their number can be determined. The simulations were applied to experimental data in chapter 6. Thus, it could be shown that mobile ions make a significant contribution to the OCVD of perovskite solar cells. j-V characteristics and OCVD transients measured as a function of temperature and illumination intensities could be quantitatively modeled simultaneously using a single global set of parameters. By the simulations it was further possible to derive a simple experimental procedure to determine the concentration and the diffusivity of the mobile ions. The possibility of describing different experiments in a uniform temperaturedependent manner strongly supports the model of mobile ions in perovskites. In summary, this work has made an important contribution to the elucidation of ionic contributions to the (photo)electrical properties of perovskite solar cells. Established experimental techniques for conventional semiconductors have been reinterpreted with respect to ionic mass transport and new methods have been proposed to draw conclusions on the properties for ionic transport. As a result, the published simulation tools can be used for a number of further studies.
Objectives: Positron emission tomography (PET) is currently considered the non-invasive reference standard for lymph node (N-)staging in lung cancer. However, not all patients can undergo this diagnostic procedure due to high costs, limited availability, and additional radiation exposure. The purpose of this study was to predict the PET result from traditional contrast-enhanced computed tomography (CT) and to test different feature extraction strategies. Methods: In this study, 100 lung cancer patients underwent a contrast-enhanced \(^{18}\)F-fluorodeoxyglucose (FDG) PET/CT scan between August 2012 and December 2019. We trained machine learning models to predict FDG uptake in the subsequent PET scan. Model inputs were composed of (i) traditional “hand-crafted” radiomics features from the segmented lymph nodes, (ii) deep features derived from a pretrained EfficientNet-CNN, and (iii) a hybrid approach combining (i) and (ii). Results: In total, 2734 lymph nodes [555 (20.3%) PET-positive] from 100 patients [49% female; mean age 65, SD: 14] with lung cancer (60% adenocarcinoma, 21% plate epithelial carcinoma, 8% small-cell lung cancer) were included in this study. The area under the receiver operating characteristic curve (AUC) ranged from 0.79 to 0.87, and the scaled Brier score (SBS) ranged from 16 to 36%. The random forest model (iii) yielded the best results [AUC 0.871 (0.865–0.878), SBS 35.8 (34.2–37.2)] and had significantly higher model performance than both approaches alone (AUC: p < 0.001, z = 8.8 and z = 22.4; SBS: p < 0.001, z = 11.4 and z = 26.6, against (i) and (ii), respectively). Conclusion: Both traditional radiomics features and transfer-learning deep radiomics features provide relevant and complementary information for non-invasive N-staging in lung cancer.
The Fifth Generation (5G) communication technology, its infrastructure and architecture, though already deployed in campus and small scale networks, is still undergoing continuous changes and research. Especially, in the light of future large scale deployments and industrial use cases, a detailed analysis of the performance and utilization with regard to latency and service times constraints is crucial. To this end, a fine granular investigation of the Network Function (NF) based core system and the duration for all the tasks performed by these services is necessary. This work presents the first steps towards analyzing the signaling traffic in 5G core networks, and introduces a tool to automatically extract sequence diagrams and service times for NF tasks from traffic traces.
In this paper, we work to understand the global IPX network from the perspective of an MVNO. In order to do this, we provide a brief description of the global architecture of mobile carriers. We provide initial results with respect to mapping the vast and complex interconnection network enabling global roaming from the point of view of a single MVNO. Finally, we provide preliminary results regarding the quality of service observed under global roaming conditions.
Automated analysis of the inner ear anatomy in radiological data instead of time-consuming manual assessment is a worthwhile goal that could facilitate preoperative planning and clinical research. We propose a framework encompassing joint semantic segmentation of the inner ear and anatomical landmark detection of helicotrema, oval and round window. A fully automated pipeline with a single, dual-headed volumetric 3D U-Net was implemented, trained and evaluated using manually labeled in-house datasets from cadaveric specimen (N = 43) and clinical practice (N = 9). The model robustness was further evaluated on three independent open-source datasets (N = 23 + 7 + 17 scans) consisting of cadaveric specimen scans. For the in-house datasets, Dice scores of 0.97 and 0.94, intersection-over-union scores of 0.94 and 0.89 and average Hausdorf distances of 0.065 and 0.14 voxel units were achieved. The landmark localization task was performed automatically with an average localization error of 3.3 and 5.2 voxel units. A robust, albeit reduced performance could be
attained for the catalogue of three open-source datasets. Results of the ablation studies with 43 mono-parametric variations of the basal architecture and training protocol provided task-optimal parameters for both categories. Ablation studies against single-task variants of the basal architecture showed a clear performance beneft of coupling landmark localization with segmentation and a dataset-dependent performance impact on segmentation ability.
In this thesis, the usage of onion-like carbon (OLC) for energy storage applications was researched regarding sustainability, performance and processability. This work targets to increase the scientific understanding regarding the role of OLC in electrodes and to facilitate a large-scale production, which is the foundation for commercial application. Research was devoted to increase the knowledge in the particular field, to yield synergistic approaches and a shared value regarding sustainability and performance.
Given the growing interest of corporate stakeholders in Metaverse applications, there is a need to understand accessibility of these technologies for marginalized populations such as people living with dementia to ensure inclusive design of Metaverse applications. We assessed the accessibility of extended reality technology for people living with mild cognitive impairment and dementia to develop accessibility guidelines for these technologies. We used four strategies to synthesize evidence for barriers and facilitators of accessibility: (1) Findings from a non-systematic literature review, (2) guidelines from well-researched technology, (3) exploration of selected mixed reality technologies, and (4) observations from four sessions and video data of people living with dementia using mixed reality technologies. We utilized template analysis to develop codes and themes towards accessibility guidelines. Future work can validate our preliminary findings by applying them on video recordings or testing them in experiments.