Refine
Has Fulltext
- yes (798)
Year of publication
- 2022 (798) (remove)
Document Type
- Journal article (798) (remove)
Language
- English (798) (remove)
Keywords
- COVID-19 (16)
- machine learning (11)
- SARS-CoV-2 (10)
- heart failure (10)
- prostate cancer (10)
- virtual reality (9)
- 3D printing (8)
- Germany (8)
- cancer (8)
- depression (8)
- inflammation (8)
- remote sensing (8)
- total knee arthroplasty (8)
- theranostics (7)
- therapy (7)
- artificial intelligence (6)
- biodiversity (6)
- children (6)
- deep learning (6)
- glioblastoma (6)
- ischemic stroke (6)
- kinematic alignment (6)
- land use (6)
- radioligand therapy (6)
- radiotherapy (6)
- stroke (6)
- PSMA (5)
- Parkinson’s disease (5)
- Sentinel-2 (5)
- blood–brain barrier (5)
- boron (5)
- fluorescence (5)
- immunohistochemistry (5)
- melanoma (5)
- microRNA (5)
- multiple myeloma (5)
- neurodegeneration (5)
- pain (5)
- quality of life (5)
- DNA damage (4)
- GFAP (4)
- PET (4)
- anxiety (4)
- aromaticity (4)
- biomarker (4)
- breast cancer (4)
- catalysis (4)
- cell death (4)
- classification (4)
- conservation (4)
- education (4)
- embodiment (4)
- fibrosis (4)
- forest (4)
- gynecology (4)
- neuroinflammation (4)
- oxidative stress (4)
- periodontitis (4)
- pharmacokinetics (4)
- physical activity (4)
- prediction (4)
- time series (4)
- Alps (3)
- Alzheimer’s disease (3)
- Aspergillus (3)
- CXCR4 (3)
- Covid-19 (3)
- Fabry disease (3)
- Google Earth Engine (3)
- NDVI (3)
- PET/CT (3)
- T cells (3)
- active zone (3)
- additive manufacturing (3)
- adolescents (3)
- antimicrobial resistance (3)
- apoptosis (3)
- astrocytoma (3)
- biomarkers (3)
- blood-brain barrier (3)
- circadian clock (3)
- climate (3)
- climate change (3)
- cytokines (3)
- earth observation (3)
- extracellular matrix (3)
- gene expression (3)
- hippocampus (3)
- hyaluronic acid (3)
- immunotherapy (3)
- induced pluripotent stem cells (3)
- liver (3)
- long-term outcome (3)
- macrophages (3)
- magnetic resonance imaging (3)
- mass spectrometry (3)
- melt electrospinning writing (3)
- melt electrowriting (3)
- mental health (3)
- meta-analysis (3)
- metabarcoding (3)
- metabolomics (3)
- myofibroblast (3)
- nephrotoxicity (3)
- neuropathic pain (3)
- nutrition (3)
- obesity (3)
- perylene bisimide (3)
- prognosis (3)
- radial (3)
- reactive oxygen species (3)
- recombination (3)
- reoperation (3)
- singlet oxygen (3)
- stemness (3)
- stress (3)
- surgery (3)
- teaching (3)
- toxicity (3)
- vitamin D (3)
- water oxidation (3)
- ACTH (2)
- AKT (2)
- ARONJ (2)
- B-cell lymphoma (2)
- C-X-C motif chemokine receptor 4 (2)
- CADe (2)
- CRISPR/Cas9 (2)
- CT (2)
- Cushing’s syndrome (2)
- DNA (2)
- EAE (2)
- EBV (2)
- ERK1/2 (2)
- Escherichia coli (2)
- HSC (2)
- HUVEC (2)
- Landsat (2)
- MRI (2)
- NAFLD (2)
- NASH (2)
- NSSI (2)
- PSMA I&T (2)
- PSMA-RADS (2)
- Parkinson's disease (2)
- PlanetScope (2)
- RKIP (2)
- RNA sequencing (2)
- SOAT1 (2)
- STR profile (2)
- SUV (2)
- TNF (2)
- TNF-α (2)
- Trypanosoma (2)
- USP28 (2)
- X-ray (2)
- X-ray crystallography (2)
- [68Ga]PentixaFor (2)
- adolescence (2)
- adrenocortical carcinoma (2)
- adverse events (2)
- age (2)
- agriculture (2)
- altitudinal gradients (2)
- anaemia (2)
- anastomotic leakage (2)
- angiogenesis (2)
- animal model (2)
- annulation (2)
- arthropods (2)
- aspiration (2)
- asthma (2)
- autophagy (2)
- azulene (2)
- bats (2)
- bias correction (2)
- biofabrication (2)
- blood (2)
- body weight modification (2)
- body weight perception (2)
- bone marrow edema (2)
- bone marrow immune-microenvironment (2)
- bone regeneration (2)
- boronate (2)
- caloric restriction (2)
- cancer metabolism (2)
- cancer stem cells (2)
- cardiac (2)
- caries (2)
- caspase-3 (2)
- cell of origin (2)
- channelrhodopsin (2)
- chemotherapy (2)
- cholestasis (2)
- chondrogenic differentiation (2)
- cisplatin (2)
- cochlear implant (2)
- colonoscopy (2)
- comparison (2)
- computed tomography (2)
- coping (2)
- critically ill (2)
- cuticular hydrocarbons (2)
- cytokinins (2)
- decellularization (2)
- dementia (2)
- diabetes (2)
- diabetic nephropathy (2)
- diagnosis (2)
- diagnostics (2)
- double intentionality (2)
- drought (2)
- drug resistance (2)
- dual-stage crosslinking (2)
- dystonia (2)
- ecosystem function (2)
- ecosystem services (2)
- editorial (2)
- endoluminal (2)
- endoradiotherapy (2)
- endovascular (2)
- epidemiology (2)
- evaluation (2)
- evolution (2)
- fMRI (2)
- fibromyalgia syndrome (2)
- food safety (2)
- food security (2)
- foraging (2)
- forest management (2)
- fracture (2)
- functional diversity (2)
- fused deposition modeling (FDM) (2)
- genetic diagnostics (2)
- gingivitis (2)
- global change (2)
- glycoprotein VI (2)
- grassland (2)
- head and neck cancer (2)
- healthcare (2)
- heart (2)
- hepatic stellate cell (2)
- herpesvirus (2)
- hydrogels (2)
- hydrology (2)
- hypercortisolism (2)
- immersion (2)
- immune checkpoint blockade (2)
- immunosuppression (2)
- in vitro (2)
- in vivo imaging (2)
- individual differences (2)
- individual‐based model (2)
- inflammasome (2)
- influenza (2)
- insect monitoring (2)
- intensive care (2)
- intervention (2)
- ischemia (2)
- knee (2)
- landscape metrics (2)
- laterality (2)
- luminescence (2)
- lung cancer (2)
- mechanical thrombectomy (2)
- meiosis (2)
- metastasis (2)
- miRNA (2)
- mice (2)
- microbial spectrum (2)
- microclimate (2)
- microglia (2)
- middle cerebral artery occlusion (2)
- mitochondria (2)
- molecular beam epitaxy (2)
- mortality (2)
- motivated reasoning (2)
- mouse model (2)
- multiple sclerosis (2)
- mutation (2)
- myocardial infarction (2)
- nanoparticles (2)
- national park (2)
- natural disturbance (2)
- navigation (2)
- negative pressure (2)
- neuroanatomy (2)
- neuroethology (2)
- neurofilament light chain (2)
- neurofilaments (2)
- octopamine (2)
- oncology (2)
- optogenetics (2)
- organic chemistry (2)
- organoids (2)
- osteoarthritis (2)
- osteogenesis (2)
- osteonecrosis of the jaw (2)
- osteoradionecrosis (2)
- outcome (2)
- outcomes research (2)
- ovarian cancer (2)
- pancreatic cancer (2)
- paraspeckles (2)
- pediatric (2)
- pelvic examination (2)
- pelvic palpation (2)
- phenotype (2)
- phosphorescence (2)
- photocatalysis (2)
- photoelectron spectroscopy (2)
- photoinduced electron transfer (2)
- phylogeny (2)
- platelet (2)
- platelets (2)
- polycycles (2)
- polycyclic aromatic hydrocarbons (2)
- posture (2)
- precision medicine (2)
- pregnancy (2)
- preterm infants (2)
- prevalence (2)
- proteomics (2)
- psychology (2)
- quality assurance (2)
- radiomics (2)
- rectal cancer (2)
- refractory (2)
- regulatory T cells (2)
- reliability (2)
- resilience (2)
- resonant tunneling diode (2)
- reverse shoulder arthroplasty (2)
- review (2)
- revision (2)
- salvage radiotherapy (2)
- schizophrenia (2)
- scleroderma (2)
- secondary structure (2)
- seroprevalence (2)
- shear stress (2)
- simulation (2)
- social anxiety (2)
- spinal muscular atrophy (2)
- stress resilience (2)
- subarachnoid hemorrhage (2)
- sympathetic nervous system (2)
- synaptonemal complex (2)
- systematic review (2)
- systemic sclerosis (2)
- temozolomide (2)
- thermogenesis (2)
- thin films (2)
- thinking (2)
- tinnitus (2)
- tissue engineering (2)
- tomography (2)
- troponin (2)
- tumor necrosis factor (TNF) (2)
- user experience (2)
- vacuum-assisted closure (2)
- virtual environments (2)
- vision (2)
- visualization (2)
- vulnerability curve (2)
- 1,4-Diborabenzene (1)
- 177Lu (1)
- 18S (1)
- 2-DG (1)
- 2-deoxy-D-glucose (1)
- 26S proteasome (1)
- 2D-perfusion angiography (1)
- 360° videos (1)
- 3D GIS analysis (1)
- 3D analysis (1)
- 3D conformal silicone bolus (1)
- 3D ex vivo models (1)
- 3D lung tumor tissue models (1)
- 3D model generation (1)
- 3D model systems (1)
- 3D models (1)
- 3D printer (1)
- 3D scaffolds (1)
- 3D tissue model (1)
- 3D-printed tooth (1)
- 4-dimethylamino-4′-cyanodiphenylacetylene (1)
- 5-HT receptors (1)
- 5-methylcytosine (1)
- 6S RNA (1)
- A375 (1)
- A549 cell line (1)
- AAA+ ATPase p97 (1)
- ACC (1)
- ACE inhibitor (1)
- ACKR4 (1)
- AD mouse modele (1)
- AD pathogenesis (1)
- AD-AID (1)
- ADAM10 (1)
- ADP-ribosyltransferases (1)
- AI (1)
- AICDA (1)
- AID-ΔE4a (1)
- AIE (1)
- AIModules (1)
- ALS (1)
- AMADEUS (1)
- AMD (1)
- AMPK (1)
- APERIO (1)
- APERIO Hybrid (1)
- APEX2 (1)
- API (1)
- ARDS (1)
- ASC (1)
- ATF6 (1)
- ATG7 (1)
- ATM (1)
- AVA (1)
- A\(_{2A}\) adenosine receptor antagonist (1)
- Achilles (1)
- Alkekengi (1)
- Alkyl(amino)carbene (1)
- Alpelisib (1)
- Altenpflege (1)
- Alzheimer's diseas (1)
- Alzheimer’s dementia (1)
- Antiparanodal Autoantibodies (1)
- Apis dorsata (1)
- Apple Watch 7 (1)
- Arp2/3 complex (1)
- Atherosclerosis, intracranial arteries (1)
- Available soil water capacity (1)
- B cell culture (1)
- B7-H1 Antigen (1)
- BDG (1)
- BDNF (1)
- BDNF stimulation (1)
- BET Inhibitor (1)
- BN compounds (1)
- BRAF mutation (1)
- BRD4 (1)
- BTN2A1 (1)
- BTN3A1 (1)
- BT_1884 (1)
- BacT/ALERT (1)
- Background Epithelioid haemangioma (1)
- Bartak (1)
- Barth syndrome (1)
- Bayesian inverse problems (1)
- Bernstein-type inequality (1)
- Beta-blocker (1)
- Bethe–Salpeter equation (1)
- Bi-Fidelity method (1)
- Bialowieza (1)
- Big Five (1)
- Bismuth (1)
- Black Scholes equation (1)
- Bland–Altman (1)
- Bloom setting (1)
- Bodenwasser (1)
- Boranes (1)
- Boron (1)
- Braak (1)
- Brain atrophy (1)
- Brain–computer interfaces (BCI) (1)
- Brassicogethes spp. (1)
- Buche (1)
- CA19-9 (1)
- CA3 (1)
- CA4 (1)
- CAPA (1)
- CAPS (1)
- CD105 (1)
- CD133 (1)
- CD147 (1)
- CD274 (1)
- CD40 (1)
- CD40L (1)
- CD44 (1)
- CD8 T cell (1)
- CD95 (1)
- CLIP (1)
- CMR (1)
- CNS cancer (1)
- CNS disorders (1)
- CNS imaging (1)
- COPD (1)
- COVID-19 pandemic (1)
- COVID-19 testing (1)
- COVID‐19 (1)
- COVID‐19 vaccination (1)
- CPF (1)
- CRC (1)
- CRH stimulation test (1)
- CRISPR (1)
- CRPS (1)
- CRY evolution (1)
- CSVD (1)
- CTCAE (1)
- CTLA-4 (1)
- CTLA-4 Antigen (1)
- CX5461 (1)
- CXCL4 (1)
- CXCL7 (1)
- CXCR4-targeting (1)
- CYP24A1 (1)
- Ca2+ homeostasis (1)
- Ca2+ ion analysis (1)
- Ca2+ leak (1)
- Ca2+ oscillation (1)
- Ca\(^{2+}\)-Imaging (1)
- Campylobacter jejuni (1)
- Candida albicans (1)
- Candida auris (1)
- Carbon Monoxide (1)
- Carbon-11 (1)
- CardioMEMS™ HF-System (1)
- Care-Arbeit (1)
- Carleson embedding theorem (1)
- Cdc48 (1)
- Cell Index (1)
- Central Asia (1)
- Chagas disease (1)
- China (1)
- Chl (1)
- Chlamydia (1)
- Chlamydia trachomatis (1)
- CholinomiRs (1)
- Chorioamnionitis (1)
- Chromophore Assembly (1)
- Chronic heart failure (1)
- Cisplatin (1)
- ClearSight\(^®\) (1)
- Climatic water balance (1)
- Clinical Neuroradiology (1)
- Clostridioides binary toxins (1)
- Cochlear duct length (1)
- Cochlear planning software (1)
- Cognitive decline (1)
- Colombia (1)
- Compound 3k (1)
- Corannulene (1)
- Covid‐19 (1)
- CreERT2 (1)
- Crohn disease (1)
- Crohn's disease (1)
- Crohn’s disease (1)
- Cu(111) (1)
- Cushing (1)
- Cushing syndrome (1)
- Cushing's (1)
- Cushing's disease (1)
- Cx3cr1 (1)
- Cyclooxygenase-2 (1)
- Cyclophilin A (1)
- DASA-58 (1)
- DIA-MS (1)
- DNA helicase (1)
- DNA repair (1)
- DNA replication (1)
- DNA sensing (1)
- DNA storage (1)
- DNA-PK (1)
- DNA-repair (1)
- DNA/RNA binding (1)
- DNA/RNA sensors (1)
- DSA (1)
- DSB damage (1)
- DUB (1)
- Dara-KDT-P(A)CE (1)
- Dark Factor of Personality (1)
- Deep learning (1)
- Denoising (1)
- Der p 23 (1)
- Deutsche Forschungsgemeinschaft (1)
- Diabetes mellitus (1)
- Dictyota (1)
- Dictyotaceae (1)
- Dirac points (1)
- Direct care workers (1)
- Dociostaurus maroccanus (1)
- Drug Therapy, Combination (1)
- Duchenne muscular dystrophy (1)
- E-H bond activation (1)
- EANM dosage card (1)
- ECM remodeling (1)
- EEG (1)
- EEOS (1)
- EHT1864 (1)
- EMMPRIN (1)
- EMT (1)
- EO data (1)
- EPR spectroscopy (1)
- ER Ca2+ imaging (1)
- ER Ca2+ store (1)
- ER stress (1)
- EU-RHAB registry (1)
- Earth Observation (1)
- Edmund Husserl (1)
- Embolism resistance (1)
- Emotional labor (1)
- Emotionsregulation (1)
- Enterobacteriaceae (1)
- Enzymes (1)
- FADS (1)
- FCS (1)
- FDM (1)
- FGF-pathway (1)
- FGFR (1)
- FGFR-inhibitors (1)
- FGFR1 (1)
- FIB-4 (1)
- FLIMbee (1)
- FRG (1)
- FRG calculations (1)
- Fabry Disease (FD) (1)
- Fabry genotype (1)
- Fabry phenotype (1)
- FcγR receptor (1)
- Fibromyalgia (1)
- Fibromyalgia syndrome (1)
- Filial piety/xiao (1)
- Fisher Z-score transformation (1)
- Fitbit Sense (1)
- Flt3L (1)
- FluidFM technology (1)
- Fluorescence Microscopy (1)
- Fn14 (1)
- FoxO3 (1)
- Foxp3 (1)
- G-protein-coupled receptors (1)
- G3BP (1)
- GABA\(_A\) (1)
- GABA\(_{A}\) receptors (1)
- GATA-3 (1)
- GFAP-astrocytopathies (1)
- GIS-analysis (1)
- GLDN variant (1)
- GLP-1 (1)
- GPCR (1)
- GPCRs (1)
- GPVI (1)
- GPVI shedding (1)
- GapN (1)
- Garmin Fenix 6 Pro (1)
- Gb3 and lyso-Gb3 biomarkers (1)
- German Hepatitis C-Registry (1)
- German Research Foundation (1)
- German/French/Italian (1)
- Gerontologie (1)
- GibS (1)
- Gleason score (1)
- Glial fibrillary acidic protein (1)
- Glioblastoma (1)
- Glioma stem cells (1)
- Google Earth (1)
- Government research funding (1)
- Greenland (1)
- Guillain-Barré syndrome (1)
- GvHD (1)
- H7N9 influenza virus (1)
- HBMEC (1)
- HCV infection (1)
- HD (1)
- HDBSCAN (1)
- HGPS (1)
- HHV-6 (1)
- HNSCC (1)
- HPV (1)
- HPc (1)
- Hamman's syndrome (1)
- Hans algorithm (1)
- Hegyi competition index (1)
- Helicobacter pylori (1)
- HiGHmed (1)
- Himalaya Karakoram (1)
- Hippo signaling (1)
- Hodgkin lymphoma (1)
- Htr1a (1)
- Htr2a (1)
- Htr2c (1)
- Hydraulic conductivity (1)
- Hydraulic plasticity (1)
- Hydrogen-deuterium (1)
- IABP (1)
- IACS (1)
- ICD-10 (1)
- ICF (1)
- ICRS (1)
- ICU staff (1)
- IDH (1)
- IDH1/2 (1)
- IGFBP2 (1)
- III–V semiconductor devices (1)
- IL-17A-inhibition (1)
- IL-6 (1)
- IL6 (1)
- IL‐10 (1)
- INR rebound (1)
- IR (1)
- ISBI (1)
- ITS2 (1)
- IgE (1)
- IgG (1)
- Ileal conduit (1)
- Ileum-Conduit (1)
- Image Aesthetic Assessment (1)
- In vitro toxicity testing (1)
- InSAR (1)
- Inclusion Rate (1)
- Indus-Ganges-Brahmaputra-Meghna (1)
- InteractionSuitcase (1)
- Interleukin-1 (1)
- Interleukin-4 (1)
- Internet of Things (1)
- IoT (1)
- Ire1 (1)
- JAQ1 (1)
- JIA (1)
- JQ1 (1)
- Jahn–Teller effect (1)
- Jena Experiment (1)
- J‐aggregates (1)
- KRAS biomarker signatures (1)
- KWIC (1)
- Klebsiella pneumoniae (1)
- Koenigs function (1)
- Kono-S anastomosis (1)
- L929 (1)
- LAMN (1)
- LASP1 (1)
- LC/MS (1)
- LCCS11 (1)
- LC–HRESIMS (1)
- LC–MS/MS (1)
- LGMDR5 (1)
- LI-rTMS (1)
- LIF (1)
- LMX (1)
- LND (1)
- LNE (1)
- LPS (1)
- Landsat archive (1)
- Landsat-8 (1)
- Laplace approximation (1)
- Large loop excision of the transformation zone (LLETZ) (1)
- Lewis acids (1)
- Li-Fraumeni syndrome (1)
- LiDAR (1)
- Lippert–Mataga plot (1)
- LoRaWAN (1)
- Long-term care (1)
- Loop electrosurgical excision procedure (LEEP) (1)
- Lymantria dispar (1)
- Lymph2Cx assay (1)
- M2 (1)
- M30 (1)
- MAP kinase pathway (1)
- MAP1B (1)
- MAS (1)
- MATQ-seq (1)
- MCC950 (1)
- ME/CFS (1)
- MEDAS (1)
- METTL8 (1)
- MGMT (1)
- MIBG (1)
- MIZ1 (1)
- MMP-1 (1)
- MMP9 (1)
- MNV type 3 (1)
- MOC fibers (1)
- MRONJ (1)
- MRSA (1)
- MRSA - methicillin-resistant Staphylococcus aureus (1)
- MSCT (1)
- MSCs (1)
- MTB (1)
- MTH1 (1)
- MTL30 (1)
- MTX (1)
- MUST-Score (1)
- MYC (1)
- Mactel 2 (1)
- Malaise trap (1)
- Mato Grosso (1)
- Medaka fish (1)
- Mekong (1)
- Memory dysfunction (1)
- Meniere’s disease (1)
- Merocyanine (1)
- Mesoarchaean (1)
- Metalloradicals (1)
- MiMIC (1)
- MitoQ (1)
- Mitochondrial Matrix Protein (1)
- Mitteleuropa (1)
- Modified Nucleotides in tRNAs (1)
- Modifizierte Sugarbaker-Technik (1)
- Monte Carlo (1)
- Mucopolysaccharidosis IIIa (1)
- Multiple myeloma (1)
- Munigua (1)
- Mwanza (1)
- Mycobacterium marinum (1)
- Mycobacterium tuberculosis (1)
- N-heterocyclic carbene (1)
- N-methylpyridinium pyrene (1)
- NADPH (1)
- NAKO (1)
- NAP-2 (1)
- NEAT1 (1)
- NF-kappa-B (1)
- NFAT (1)
- NFATc1 (1)
- NFkappaB (1)
- NFκB (1)
- NK cell (1)
- NLPHL (1)
- NLRP3 (1)
- NOAC (1)
- NONO (1)
- NPWT (1)
- NRAS mutation (1)
- NSCLC (1)
- NSG (1)
- NaV1.8 (1)
- Naphthylisoindolinone alkaloids (1)
- National Science Foundation (1)
- Neisseria gonorrhoeae (1)
- Nestin (1)
- NfL (1)
- Nicandra (1)
- Nickel ComplexCyclic (1)
- Nile Delta (Egypt) (1)
- Nodo-parandopathy (1)
- Northern Bald Ibis (1)
- Npy (1)
- Npyr1 (1)
- Npyr2 (1)
- Nucleic Acids (1)
- Nucleobase Analogue (1)
- ODE (1)
- OHIP-49 (1)
- ONJ (1)
- Ockham (1)
- Olea (1)
- Optical Music Recognition (1)
- Orai2 (1)
- Organelles (1)
- Orthoptera (1)
- Osteopontin (1)
- Oxford knee score (1)
- PBM (1)
- PCDHGC3 (1)
- PCL retention (1)
- PCa (1)
- PD-1 (1)
- PDE (1)
- PDE4-I (1)
- PEGylation (1)
- PET imaging (1)
- PET/MR systems (1)
- PETRI-seq (1)
- PF4 (1)
- PI3K (1)
- PIK3R1 (1)
- PKA (1)
- PKM2 (1)
- PMMA (1)
- PNA (peptide nucleic acid) (1)
- PP2A (1)
- PRAME (1)
- PRRT (1)
- PSA (1)
- PSA response (1)
- PSMA PET/CT (1)
- PSMA-617 (1)
- PSMA-TV (1)
- PSMA‐617 (1)
- PTEN (1)
- PTSD (1)
- Paeonia (1)
- Parastomale Hernie (1)
- Parent Piano-Stool Complex (1)
- Parkinson (1)
- Pauli procedure (1)
- Pauli-Verfahren (1)
- Pearson correlation coefficient (1)
- Pelvisio® (1)
- Peter Singer (1)
- Pfam domain (1)
- Phaeophyceae (1)
- Physalis (1)
- Pnictogen reduction (1)
- PolSAR (1)
- Portland cement (1)
- Precipitation gradient (1)
- Professionalism (1)
- Programmed Cell Death 1 Receptor (1)
- QIVIVE (1)
- R-CHOP (1)
- R0 (1)
- RADS (1)
- RAP (1)
- RCT (1)
- RECK (1)
- REMO-iMOVE (1)
- RIM1α (1)
- RLT (1)
- RNA (1)
- RNA Methyltransferase (1)
- RNA interference (1)
- RNA secondary structure (1)
- RNA-binding proteins (1)
- RNAPOL1 (1)
- RNase III (1)
- ROI (1)
- ROS (1)
- RS-13 (1)
- RTPS1 (1)
- RTPS2 (1)
- RYGB (1)
- Rac1 (1)
- Raman micro-spectroscopy (1)
- Reciprocity (1)
- Rhizopus (1)
- Rho GTPase (1)
- Rotary EXcitation (REX) (1)
- Roux-en-Y gastric bypass (1)
- Roux-en-Y gastric bypass surgery (1)
- Ruthenium complexes (1)
- Rv3034c (1)
- S100A8/S100A9 (1)
- SAMD3 (1)
- SAR (1)
- SARS‐CoV‐2 infection (1)
- SEM (1)
- SERCA (1)
- SF-12 (1)
- SF3 helicase (1)
- SGLT2 inhibitors (1)
- SIRT1 (1)
- SKY analysis (1)
- SLA (1)
- SMLM (1)
- SMN granules (1)
- SOC content prediction (1)
- SP-fixation (1)
- SPECT (1)
- SPECT Scanner (1)
- SSI (1)
- SSTR-RADS (1)
- STBS (1)
- STEM classroom (1)
- STEM education (1)
- STEM integration (1)
- STEMI (1)
- STORM (1)
- STS (1)
- SV pool (1)
- SWLS (1)
- Scarabaeidae (1)
- Schwann cell (1)
- Schwann cell differentiation (1)
- Scotus (1)
- Sentinel-1 (1)
- Sentinel-1 (S-1) synthetic aperture radar (SAR) (1)
- Sierra Nevada (1)
- Singhbhum Craton (1)
- Skin Neoplasms (1)
- Snow Line Elevation (1)
- Sodium-Glucose Cotransporters (SGLTs) (1)
- Southeast Asia (1)
- Staphylococcus (1)
- Supramolecular Element (1)
- Switzerland (1)
- Syk (1)
- T cell plasticity (1)
- T cell receptor (1)
- T-cell epitope (1)
- T-cells (1)
- T-shaped π-π stacking (1)
- T1rho (1)
- T1ρ (1)
- TD-DFT (1)
- TGF-β (1)
- TGFβ signaling (1)
- TH1579 (1)
- TH588 (1)
- TKA (1)
- TKI (1)
- TMEM43 (1)
- TNF alpha (1)
- TNF receptor 2 (TNFR2) (1)
- TNF receptor associated factor 1 and 2 (TRAF1, TRAF2) (1)
- TNF receptor associated factor 2 (TRAF2) (1)
- TNF-related apoptosis-inducing ligand (1)
- TNFR2 (1)
- TRRAP (1)
- TTFields (1)
- TTS (1)
- TT\(_{1rho}\) mapping (1)
- TWEAK (1)
- TXNIP (1)
- T\(_{1P}\) dispersion (1)
- T\(_{1P}\) mapping (1)
- T\(_{reg}\) and Foxp3 (1)
- Taita Hills (1)
- Takotsubo cardiomyopathy (1)
- Takotsubo syndrome (1)
- Tanzania (1)
- Th17 (1)
- Th17 cells (1)
- Townes (1)
- Treg (1)
- Tregs (regulatory T cells) (1)
- Trichternetz (IPST) (1)
- Trypanosoma brucei gambiense (1)
- TspanC8 (1)
- Tumor Treating Fields (TTFields) (1)
- UAV (1)
- UMAP (1)
- Unc-13 (1)
- Uranium (1)
- Usher syndrome (1)
- V1–V9 (1)
- V4 (1)
- V7/V8 (1)
- VA-ECMO (1)
- VAC (1)
- VARS2 (1)
- VDR (1)
- VEGF (1)
- WNT (1)
- WNT signaling (1)
- Warburg effect (1)
- Western Europe (1)
- Withings ScanWatch (1)
- Wnt signaling (1)
- X-chromosomal inactivation (1)
- XAI (1)
- XBP1 (1)
- XLH (1)
- XNA (1)
- XPA (1)
- XR (1)
- XRPD (1)
- Xylem (1)
- Xylem vulnerability curve (1)
- Y chromosome degeneration (1)
- YAP (1)
- YouTube (1)
- Zagros oak forests (1)
- ZfKD (1)
- Zosterops silvanus (1)
- [11C]-Choline PET/CT (1)
- [11C]-Methionine (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]Lu-PSMA I&T (1)
- [177Lu]PentixaTher (1)
- [18F]FDG positron emission tomography (1)
- [90Y]PentixaTher (1)
- [99mTc]-Sestamibi scan (1)
- [\(^{68}\)Ga]Ga-FAPI (1)
- \(^{177}\)Lu (1)
- \(^{18}\)F-DCFPyL PET/CT (1)
- \(^{18}\)F-PSMA-1007 (1)
- \(^{1}\)H-\(^{13}\)C HETCOR (1)
- aPC (1)
- abandoned land (1)
- abdominal compartment syndrome (1)
- abdominal trauma (1)
- accelerated hyperfractionation (1)
- access (1)
- accuracy (1)
- acebutolol (1)
- acetylation (1)
- acetylsalicylic acid (1)
- acetyltransferase (1)
- achiasmatic (1)
- acid ceramidase inhibitor ceranib-2 (1)
- acid sphingomyelinase (1)
- acitretin (1)
- acoustic stream (1)
- acrylate-endcapped urethane-based polymer (AUP) (1)
- actin (1)
- action (1)
- action effects (1)
- action potential (1)
- action representation (1)
- activity (1)
- activity-dependent slowing (1)
- acute brain slices (1)
- acute hypobaric hypoxia (1)
- acute kidney injury (1)
- adalimumab (1)
- adaptation (1)
- adaptive tutoring (1)
- adhesion molecule (1)
- adipogenic differentiation (1)
- adrenal cancer (1)
- adrenal surgery (1)
- adrenalectomia (1)
- adrenocortical adenocarcinoma (1)
- adrenocortical adenoma (1)
- adrenocortical cancer (1)
- adrenocortical development (1)
- adrenocortical tumor (1)
- adrenocortical tumors (1)
- adsorption (1)
- adult learning (1)
- adult stem cells (1)
- adult-onset (1)
- advanced cutaneous squamous cell carcinoma (1)
- adverse drug reaction (1)
- adverse effects (1)
- adverse event (1)
- adverse outcome pathway (1)
- adverse outcome pathway (AOP) (1)
- aerobiology (1)
- aerodynamic drag reduction (1)
- affective appraisal (1)
- agar diffusion test (1)
- age stereotypes (1)
- age-related differentially methylated regions (ageDMRs) (1)
- age-related hearing loss (1)
- agency (1)
- aggregation (1)
- aging (1)
- agonist (1)
- agonistic antibodies (1)
- agri-environment scheme (1)
- agricultural drought (1)
- agricultural pests (1)
- agroforestry (1)
- alkyl halides (1)
- alkylideneborane (1)
- allergens (1)
- allergy (1)
- alloSCT patients (1)
- allometry (1)
- alpha diversity (1)
- alpine plants (1)
- altered fractionation (1)
- amino acid (1)
- amino acid restriction (1)
- ammonia borane (1)
- ampicillin (1)
- analgesic medication (1)
- anaphylaxis (1)
- anastomotic leak (1)
- anatomic shoulder arthroplasty (1)
- ancillary services (1)
- aneurysmal subarachnoid haemorrhage (1)
- angiogenesis inhibitors (1)
- angiography (1)
- anhedonia (1)
- animal behaviour (1)
- animal models (1)
- anion channel (1)
- anionic carbene (1)
- anions (1)
- ankle (1)
- anniversary (1)
- annotation (1)
- anorectal abscess (1)
- ant-colony optimization (1)
- anthocyanin (1)
- anthocyanins (1)
- anthropometric measurement (1)
- anthroposphere (1)
- anti-Parkinson agents (1)
- anti-bacterial agents (1)
- anti-hormonal therapy (1)
- anti-inflammatory agents (1)
- antibacterial drug resistance (1)
- antibiotic bone concentration (1)
- antibiotic elution (1)
- antibiotic prescribing quality (1)
- antibiotic resistance (1)
- antibiotics (1)
- antibodies (1)
- antibody fusion protein (1)
- antibody–drug conjugates (1)
- anticancer activity (1)
- anticoagulation (1)
- antidepressant (1)
- antigen testing (1)
- antimicrobial stewardship (1)
- antimony (1)
- antiphospholipid syndrome (1)
- antiresorptive drug-related osteonecrosis of the jaw (1)
- antitumor peptide (1)
- antiviral activity (1)
- anti‐SARS‐CoV‐2‐spike IgG (1)
- aortic dissection (1)
- apheresis technologies (1)
- apheresis-therapeutic (1)
- apis mellifera (1)
- aplastic anemia (1)
- apolipoprotein J (1)
- appearance (1)
- appendectomy (1)
- appendicitis (1)
- appendix (1)
- applied ethics (1)
- approach (1)
- approach-avoidance decisions (1)
- approach–avoidance (1)
- aquaporin (1)
- area‐concentrated search (1)
- arene-fluoroarene (1)
- aromatic amides (1)
- arrhythmogenesis (1)
- arrhythmogenic cardiomyopathy (1)
- arteriovenous extracorporeal hemadsorption technique (1)
- arteriovenous loop (1)
- arthritis (1)
- arthrography (1)
- arthrogryposis (1)
- arthropod predators (1)
- artificial base pair (1)
- artificial photosynthesis (1)
- aseptic loosening (1)
- ash dieback (1)
- aspirin (1)
- astaxanthin (1)
- astrocytes (1)
- asymptotically flat ends (1)
- at-home sampling (1)
- atherosclerosis (1)
- atmospheric circulation (1)
- atomic layer deposition (1)
- atraumatic surgery (1)
- atrial fibrillation (1)
- attention capture (1)
- attention deficit/hyperactivity disorder (ADHD) (1)
- attitude of health personnel (1)
- atypical teratoid rhabdoid tumors (1)
- auction based task assignment (1)
- audiological services (1)
- authoring platform (1)
- autoantibodies (1)
- autobiographical memory (1)
- autoimmune (1)
- autoimmune disease (1)
- autoimmunity (1)
- autoinhibition (1)
- autoinjector (1)
- autologous hematopoietic stem cell transplantation (1)
- automation (1)
- autonomic nervous system (1)
- avatar embodiment (1)
- avatars (1)
- avoidable blood loss (1)
- awake prone positioning (1)
- axial alignment (1)
- axonopathy (1)
- azaborole (1)
- azido borane (1)
- background knowledge (1)
- backward orbit (1)
- bacterial (1)
- bacterial cellulose dressing (1)
- bacterial infection model (1)
- bacterial meningitis (1)
- bacterial pathogens (1)
- band structure (1)
- bargaining behavior (1)
- bark beetle disturbance (1)
- base of support (1)
- bee abundance (1)
- bee body size (1)
- bee decline (1)
- bee pollination (1)
- bee species richness (1)
- beech forests (1)
- beetle communities (1)
- behavior perception (1)
- beta diversity (1)
- beta-lactam (1)
- beta-oxidation (1)
- beta‐d‐glucan (1)
- biased signaling (1)
- bicommutators (1)
- bilberry (1)
- bile (1)
- binaural hearing (1)
- binding pocket (1)
- bioactivities (1)
- biochemical assays (1)
- bioconjugation (1)
- biodegradable (1)
- biodiversity exploratories (1)
- biodiversity–ecosystem functioning relationship (1)
- bioinformatics (1)
- bioink (1)
- biological activities (1)
- biologics (1)
- biomass (1)
- biomimetic tissue models (1)
- biophysics (1)
- bioprinting (1)
- biosensor (1)
- biosimilar (1)
- biosonar (1)
- biosphere (1)
- birds (1)
- birth cohort (1)
- birth hospitals (1)
- bisphenol A (1)
- bisphosphonates (1)
- bisulfite pyrosequencing (1)
- black currant (1)
- bladder cancer (1)
- bleeding on probing (1)
- blood contamination (1)
- blood flow (1)
- blood nerve barrier (1)
- blood pressure (1)
- blood processing (1)
- blood purification (1)
- blood stream infections (1)
- blood vessel (1)
- blood-brain barrier (BBB) model (1)
- bloodstream infection (1)
- blood–labyrinth barrier (1)
- body awareness (1)
- body image distortion (1)
- body image disturbance (1)
- body language (1)
- body mass index (BMI; kg/m\(^2\)) (1)
- body representation (1)
- body size (1)
- bonding (1)
- bone (1)
- bone biology (1)
- bone bruise (1)
- bone cement (1)
- bone defect (1)
- bone fractures (1)
- bone loss (1)
- bone marrow failure (1)
- bone marrow homing (1)
- bone marrow lesion/edema (1)
- bone marrow mesenchymal stromal cells (BM-MSCs) (1)
- bone marrow-derived monocytes (1)
- bone metastasis (1)
- bone model (1)
- bone morphogenetic protein 2 (BMP2) (1)
- bone morphology (1)
- bone replacement material (1)
- boolean in silico models (1)
- boracycle (1)
- boranes (1)
- boric acid (1)
- boronate esters (1)
- boronic acid (1)
- borylation (1)
- brain (1)
- brain cancer (1)
- brain development (1)
- brain disorders (1)
- brain endothelial cells (1)
- brain state (1)
- brain tumor (1)
- brain-metastasis (1)
- brain–liver chip (1)
- breakthrough infection (1)
- breast cancer metastases (1)
- breast cancer predisposition genes (1)
- breast neoplasms (1)
- brown seaweeds (1)
- bruxism (1)
- bulk-fill technique (1)
- bullous pemphigoid (1)
- bumblebees (1)
- buparlisib (1)
- burden (1)
- burned area (1)
- burst abdomen (1)
- butyrophilin (1)
- c-MYC (1)
- c-Myc (1)
- c-fos (1)
- c-reactive protein (1)
- cDC2 subset (1)
- cGMP (1)
- cable-clamp implants (1)
- cad-cam (1)
- calcium-magnesium phosphate cement (1)
- calipered (1)
- calprotectin (1)
- cancer care (1)
- cancer diagnosis (1)
- cancer dissemination (1)
- cancer predisposition (1)
- cancer prevention (1)
- candidemia (1)
- canonicalization (1)
- canopy cover loss (1)
- canopy herbivory (1)
- capsule endoscopy (1)
- carbene (1)
- carbon footprint (1)
- carbon nanotubes (1)
- carbonyl (1)
- carboxylation (1)
- cardiac MRI (1)
- cardiac catheterization/ intervention (1)
- cardiac implants (1)
- cardiac innervation imaging (1)
- cardiac magnetic resonance imaging (1)
- cardiac metabolism (1)
- cardiac nerve (1)
- cardiac patch (1)
- cardiac thrombi (1)
- cardiac training group (1)
- cardioactive factor (1)
- cardiolipin (1)
- cardiomyocyte (1)
- cardiomyocytes (1)
- cardiomyopathy (1)
- cardiovascular diseases (1)
- cardiovascular drugs (1)
- cardiovascular genetics (1)
- cardiovascular magnetic resonance (CMR) (1)
- cardiovascular risk factors (1)
- career adaptability (1)
- career coping (1)
- career engagement (1)
- career satisfaction (1)
- cartilage (1)
- cartilage defect (1)
- cartilage regeneration (1)
- case report (1)
- catalyst (1)
- catalyst synthesis (1)
- catalytic mechanisms (1)
- caudate nucleus (1)
- causal networks (1)
- celecoxib (1)
- cell imaging (1)
- cell membrane model (1)
- cell rich blue nevus (1)
- cell-based therapies (1)
- cell-cell interactions (1)
- cellular inhibitor of apoptosis 1/2 (cIAP1/2) (1)
- cellular origin (1)
- cellular reprogramming (1)
- cement pastes (1)
- cemiplimab (1)
- central autonomic network (1)
- central complex (1)
- central venous catheter (1)
- centripetal technique (1)
- ceramics (1)
- ceramidase (1)
- ceramide (1)
- ceramides (1)
- cerebEND (1)
- cerebral vasospasm (1)
- cerebrospinal fluid (1)
- certifying algorithm (1)
- cervical dysplasia (1)
- chain cover (1)
- chalcidoid wasps (1)
- chalcogens (1)
- change detection (1)
- change vector analysis (1)
- channel management (1)
- characterization and analytical techniques (1)
- charge transfer (1)
- checkpoint inhibitor therapy (1)
- chemical communication (1)
- chemical identifier (1)
- chemical mimicry (1)
- cheminformatics (1)
- chemokines (1)
- chemoradiotherapy (1)
- chenodeoxycholate (1)
- childhood (1)
- childhood cancer (1)
- chirality transfer (1)
- chitinase-3-like protein 1 (1)
- choanoflagellates (1)
- cholesterol metabolism (1)
- cholinergic system (1)
- chromatin (1)
- chromosome inversion (1)
- chronic heart failure (1)
- chronic kidney disease (1)
- chronic mesenteric ischemia (1)
- chronic musculoskeletal pain (1)
- chronic stress (1)
- chrysididae (1)
- circadian clock neurons (1)
- circularly polarized luminescence (1)
- circulation type (CT) (1)
- circulatory assist devices (1)
- citalopram (1)
- class II restoration (1)
- classical Hodgkin lymphoma (1)
- claudin-1 (1)
- click chemistry (1)
- climate change mitigation (1)
- climate changes (1)
- climate models (1)
- climatic factors (1)
- climatic gradients (1)
- clinical outcomes (1)
- clinical practice guideline (1)
- clinical routine data (1)
- clinical studies/trials (1)
- clinical trial (1)
- clinical trials (1)
- clock network (1)
- clusterin transporter (1)
- co-culture (1)
- coal mining area (1)
- coastal erosion (1)
- coastline dynamics (1)
- cochlea (1)
- cochlear implantation (1)
- cochlear implants (1)
- cocoa (1)
- cocrystallization (1)
- coexistence (1)
- cognitive (1)
- cognitive basis (1)
- cognitive conflict (1)
- cognitive control (1)
- cognitive decline (1)
- cognitive impairment (1)
- coherence (1)
- coherent anti-Stokes Raman scattering (CARS) microscopy (1)
- coherent multidimensional spectroscopy (1)
- cohort studies (1)
- cold stress (1)
- cold temperature (1)
- cold-shock protein (1)
- coleoptera (1)
- collaborative research (1)
- collagen (1)
- collision (1)
- colon resection (1)
- colony stimulating factor 1 (1)
- color perception (1)
- color-coding (1)
- colorectal cancer (1)
- colorectal carcinoma (1)
- combinatorial libraries (1)
- combined retinal dystrophy (1)
- common blue nevus (1)
- community structure (1)
- comorbid diseases (1)
- comparative sequence analysis (1)
- compensation (1)
- competition (1)
- complementary currencies (1)
- complex polynomials (1)
- complex regional pain syndrome (1)
- complication (1)
- complications (1)
- composite detection (1)
- composition of functions (1)
- compressed sensing (1)
- computational biology and bioinformatics (1)
- computational docking (1)
- computational modeling (1)
- computer software (1)
- condenser capacity (1)
- conditioned place preference (1)
- conference abstracts (1)
- confidence (1)
- confixes (1)
- confounders (1)
- congruence (1)
- congruency (1)
- conjugated molecule (1)
- connectivity (1)
- consequences of ethical criticism (1)
- conservation biology (1)
- conspiracy theories (1)
- contact inhibition (1)
- context (1)
- context-dependent preferences (1)
- controller failure recovery (1)
- conventional laparoscopic appendectomy (1)
- conversational agents (1)
- convex bipartite graph (1)
- coordination oligomer (1)
- coping style (1)
- copper (1)
- coppice (1)
- coprophagous beetles (1)
- copula (1)
- coral reef ecosystem (1)
- coral reef resilience (1)
- coronary arteries (1)
- correction (1)
- correlated oxides (1)
- cortical neurons (1)
- cortisol (1)
- cost-effectiveness (1)
- covalent coupling (1)
- covalent organic framework (1)
- craniofacial orthodontics (1)
- creativity (1)
- critical illness (1)
- cross-cultural comparison (1)
- cross-sectional studies (1)
- crossing-over (1)
- crown delineation (1)
- cryo-electron microscopy (1)
- cryptic peptides (1)
- cryptochrome (1)
- cryptochrome/photolyase family (1)
- crystal engineering (1)
- crystalline (1)
- cultural and media studies (1)
- culturally aware (1)
- custom-made implant (1)
- cutaneous T-cell lymphoma and Merkel cell carcinoma (1)
- cutting events (1)
- cyanoborate (1)
- cyanoborates (1)
- cyclic (alkyl)(amino)carbenes (1)
- cycling (1)
- cyclodehydrogenation (1)
- cyclodextrin (1)
- cyclophanes (1)
- cyclosporine A (1)
- cytochrome P450 3A4 (CYP3A4) (1)
- cytokine storm (1)
- cytopenia (1)
- cytoskeleton (1)
- dSTORM (1)
- dabrafenib (1)
- data filtering (1)
- deadwood (1)
- decentralized control (1)
- decision process (1)
- decision-making (1)
- decline (1)
- decomposition (1)
- deep brain stimulation (1)
- deep brain stimulation (DBS) (1)
- deep neck infection (1)
- defective ribosomal products (1)
- defoliation severity (1)
- deforestation (1)
- dehydrocoupling (1)
- delayed rectifier potassium channel (1)
- delivery mode (1)
- deltoid muscle (1)
- dementia with Lewy bodies (1)
- dendritic cells (1)
- dental education (1)
- dental status (1)
- dentate gyrus (1)
- dentin sealing (1)
- desiccation resistance (1)
- design (1)
- design science research (1)
- design theory (1)
- desmin (1)
- detachment force quantification (1)
- developmental biology (1)
- developmental paths (1)
- dexamethasone (1)
- diabetes mellitus (1)
- diabetic retinopathy (1)
- diagnosis in Fabry disease (1)
- diagnostic blood loss (1)
- diagnostic delay (1)
- diagnostic medicine (1)
- diaphragmatic hypomotility (1)
- diary (1)
- diborene (1)
- diet (1)
- diet breadth (1)
- differential gene expression (1)
- differential nash games (1)
- differentiation (1)
- diffuse astrocytoma (1)
- diffuse large B-cell lymphoma (1)
- digital nativity (1)
- digitalisation initiative (1)
- dihydrosphingosine-1-phosphate lyase (1)
- dipole-dipole interaction (1)
- direct gaze (1)
- direct-acting antiviral (1)
- disability (1)
- disaggregation (1)
- disease severity (1)
- disembodiment (1)
- dismutations (1)
- displacement (1)
- dissolution (1)
- distal occlusion (1)
- distance compression (1)
- distance learning (1)
- distance-decay function (1)
- distance‐based specialization index (1)
- distress (1)
- disturbance extent (1)
- disturbance index (1)
- disturbance severity (1)
- diurnal (1)
- diversity (1)
- diversity gradients (1)
- diversity–disturbance relationship (1)
- donor-acceptor dyad (1)
- donor-site morbidity (1)
- donor–acceptor (1)
- donor–acceptor dyads (1)
- dopamine transporter (DAT) (1)
- dorsal clock neurons (1)
- dose escalation (1)
- drag area (1)
- drain (1)
- driving forces (1)
- drop on demand (1)
- drought impact (1)
- drug adverse reaction (1)
- drug allergy (1)
- drug discovery (1)
- drug effectiveness (1)
- drug exanthema (1)
- drug hypersensitivity (1)
- drug interaction (1)
- drug intoxication (1)
- drug monitoring (1)
- drug target (1)
- drug toxicity (1)
- drug-induced liver injury (DILI) (1)
- drug–drug interactions (DDIs) (1)
- dry spinning (1)
- dual guidance (1)
- dual-energy computed tomography (1)
- dual-room trauma suite (1)
- dung beetle (1)
- duplex structure (1)
- dyadic product BMO (1)
- dye assembly (1)
- dyes/pigments (1)
- dynamic culture (1)
- dynamic programming (1)
- dynamics (1)
- dynamics of ribosomal assembly (1)
- dynamometer (1)
- dyskinesia (1)
- dysphagia (1)
- dysplasia (1)
- dystrophin (1)
- earliest autobiographical memories (1)
- early memory (1)
- early-onset gastric cancer patients (1)
- early-onset predictors (1)
- eating and body weight disorders (1)
- eating disorders (1)
- echocardiography (1)
- ecological momentary assessment (1)
- ecosystem functioning (1)
- ectodomain cleavage (1)
- ectopic (1)
- edge detection (1)
- editorial board (1)
- effects (1)
- efficacy (1)
- efficiency (1)
- efgartigimod (1)
- egoism (1)
- ehealth (1)
- elamipretide (1)
- elbow joint (1)
- electric acoustic stimulation (EAS) (1)
- electric vehicles (1)
- electrical excitability (1)
- electroactive polymers (1)
- electrochemistry (1)
- electrohydrodynamic (1)
- electrohydrodynamics (1)
- electromyographic (1)
- electron tomography (1)
- electronic phase transitions (1)
- electronic structure (1)
- electrophilic stress (1)
- electrospinning (1)
- elevation (1)
- elevation gradient (1)
- elevational diversity patterns (1)
- embolism resistance (1)
- emergency (1)
- emergency preparedness (1)
- emotion regulation (1)
- emotions (1)
- empathy (1)
- empirical quantile mapping (1)
- encephalopathy (1)
- encryption (1)
- endemic pemphigus foliaceus (1)
- endocrine cancer (1)
- endocrine disruption (1)
- endodontics (1)
- endogenous hypercortisolism (1)
- endoglin (1)
- endoscopic (1)
- endoscopy (1)
- endothelial (1)
- endothelial cells (1)
- endotheliitis (1)
- endotoxin (1)
- endovascular therapy (1)
- endovascular treatment (1)
- enediyne (1)
- energy restriction (1)
- energy transfer (1)
- entomology (1)
- entrapment, traction (1)
- environmental factors (1)
- environmental modeling (1)
- environmental monitoring (1)
- enyne (1)
- enzyme (1)
- enzyme mechanisms (1)
- eosinophils (1)
- epicondyles (1)
- epidural anaesthesia (1)
- epigenetics (1)
- epistemic beliefs (1)
- epithelial cells (1)
- epitope prediction (1)
- epstein-barr virus (1)
- esophageal perforation (1)
- estrogens (1)
- ethics (1)
- eudaimonia (1)
- evolutionary arms race (1)
- evolutionary rescue (1)
- ex vivo (1)
- examples and counterexamples (1)
- exchange reaction (1)
- excimer (1)
- excipient (1)
- excitatory/inhibitory imbalance (1)
- exciton (1)
- exciton coupling (1)
- excitons (1)
- exercise (1)
- exosomes (1)
- expenditure paradox (1)
- experience (1)
- experiences (1)
- experiment (1)
- experimental design (1)
- experimental stroke (1)
- expert recommendation (1)
- explainable AI (1)
- explainable artificial intelligence (1)
- explainable machine learning (1)
- explanation complexity (1)
- expression (1)
- extended matching questions (1)
- extended reality (XR) (1)
- extracellular vesicles (1)
- extracorporeal hemadsorption (1)
- extracorporeal membrane oxygenation (1)
- extracorporeal membrane oxygenation (ECMO) (1)
- extracorporeal techniques in hemadsorption therapy (1)
- extracranial malignant rhabdoid tumor (1)
- eye diseases (1)
- eye gaze (1)
- eye tracking (1)
- e‐commerce (1)
- face perception (1)
- facial nerve (1)
- facilitation (1)
- fairness evaluation vs. cognitive effort (1)
- familial DCM (1)
- familial breast cancer (1)
- family caregiver (1)
- family caregivers (1)
- family relations (1)
- fascial closure (1)
- fascination with biology (1)
- fast track rehabilitation (1)
- fast-track-concepts (1)
- fatigue (1)
- faulting (1)
- fear conditioning (1)
- fear expression (1)
- fear stimuli (1)
- fears (1)
- feasibility study (1)
- feeding (1)
- female Fabry patients (1)
- female aggression (1)
- femur (1)
- fenestration (1)
- ferroptosis (1)
- fiber (1)
- fibroblast activation protein (1)
- fibromyalgia (1)
- filamin-C (1)
- financial linkages (1)
- fire (1)
- fish bone (1)
- fish oil (1)
- fistulizing Crohn’s Disease (1)
- flare phenomenon (1)
- flat silicone bolus (1)
- flexible CO2 laser (1)
- flight control (1)
- flood (1)
- floral larceny (1)
- flotillin-1 lipid rafts (1)
- flow path (1)
- flower morphology (1)
- flower visitors (1)
- flowering grassland plants (1)
- fluorescence correlation spectroscopy (1)
- fluorescence in situ hybridisation (1)
- fluorescence in situ hybridization (FISH) (1)
- fluorescence resonance energy transfer (FRET) (1)
- fluorescence-aided identification technique (1)
- fluorescent probes (1)
- fluoroquinolones (1)
- fluoxetine (1)
- fly pollination (1)
- flybow (1)
- focal radiotherapy (1)
- focused surgical approach (1)
- folding (1)
- foliation (1)
- food contact materials (1)
- food quality (1)
- food supplement (1)
- foot (1)
- forage resources (1)
- foragers (1)
- force feedback (1)
- forearm (1)
- forecast (1)
- foreign body ingestion (1)
- forensic neuropathology (1)
- forensic neurotraumatology (1)
- forest communities (1)
- forest conversion (1)
- forest degradation (1)
- forest ecology (1)
- forest fragmentaion (1)
- forest proximity (1)
- forgotten joint score (1)
- formation control (1)
- fpVCT (1)
- fractionated spacecraft (1)
- fracture sequelae (1)
- fracture sequelae shoulder (1)
- fragility fracture (1)
- fragment screening (1)
- fragmentation (1)
- framing (1)
- free skin grafts (1)
- freezing of gait (1)
- freezing of gait (FOG) (1)
- fruit (1)
- fruit temperature (1)
- fully convolutional neural networks (1)
- functional initiators (1)
- functional magnetic resonance imaging (1)
- functional renormalization group (1)
- fungal sinusitis (1)
- fungi (1)
- funnel mesh (IPST) (1)
- furan (1)
- fusion (1)
- future prediction (1)
- fuzzy classification (1)
- gait analysis (1)
- gait initiation (1)
- gait modulation (1)
- galectin-2 (1)
- gallotannins (1)
- gambling (1)
- gamification (1)
- gamma diversity (1)
- gastric bypass (1)
- gastric cancer in young patients (1)
- gastric emptying (1)
- gastroenterology (1)
- gastrointestinal perforation (1)
- gaze stability (1)
- gefitinib (1)
- gene (1)
- gene regulation (1)
- gene variant (1)
- general practice (1)
- genetic algorithm (1)
- genetic association (1)
- genetic susceptibility (1)
- genetic testing (1)
- genotype-phenotype correlation (1)
- genotype/phenotype correlation (1)
- geoarchaeology (1)
- geoelectrical monitoring (1)
- geometry (1)
- geomorphological mapping (1)
- geomorphology (1)
- geophysical prospection (1)
- geovisualization (1)
- gephyrin (1)
- geriatric (1)
- german clinical cancer registry group (1)
- germline mutation (1)
- gingival (1)
- glaucoma (1)
- glaucoma progression (1)
- glecaprevir/pibrentasvir (1)
- glenoid (1)
- glenoid bonegrafting (1)
- glial damage (1)
- glial fibrillary acidic protein (1)
- glioblastoma multiforme (1)
- glioma (1)
- gliomedin (1)
- global warming (1)
- globotriaosylceramide (1)
- globus pallidus pars interna (GPi) (1)
- glucocorticoid receptor (1)
- glucose restriction (1)
- glycogen synthase kinase-3 β (GSK-3β) (1)
- glycolysis (1)
- glycolytic flux control (1)
- glycopeptide antibiotics (1)
- glycoprotein receptor Ibα (1)
- gold (1)
- gradient boosting machine (1)
- grading system of chondral defects (1)
- graft versus host disease (1)
- granulocytes (1)
- granulophagy (1)
- granulostasis (1)
- graph algorithm (1)
- gray level co-occurrence matrix (1)
- grazing (1)
- green energy (1)
- group 8 metals (1)
- growth rate (1)
- guanine nucleotide exchange factor (GEF) (1)
- guard cell (1)
- guideline adherence (1)
- guideline usage (1)
- guild constancy (1)
- gypsy moth (1)
- hERG (1)
- habitat change (1)
- habitat types (1)
- haemostasis (1)
- halophyte (1)
- hand movements (1)
- hand pollination (1)
- handball (1)
- harmonic measure (1)
- harvests (1)
- hawkmoth (1)
- head depression fractures (1)
- health care workers (1)
- health effects (1)
- health literacy (1)
- health tracker (1)
- health-related fitness (1)
- health-related quality of life (1)
- healthcare costs (1)
- healthcare professionals (1)
- healthcare workers (1)
- hearing aid (1)
- hearing impairment (1)
- hearing loss (1)
- hearing preservation (1)
- heart failure training group (1)
- heavy rainfall (1)
- hedonia (1)
- helicase (1)
- helicene (1)
- hematopoiesis (1)
- hematopoietic stem cells (1)
- hematotoxicity (1)
- heme oxygenase-1 (1)
- hemibrain (1)
- hemolysin (1)
- hepatitis C virus (1)
- hepatocellular carcinoma (1)
- hepatotoxicity (1)
- herbivores (1)
- hereditary alpha-tryptasemia (1)
- hernia (1)
- heterochromatin (1)
- heterogeneity (1)
- heteroskedasticity (1)
- hiPSC-CM (1)
- hidden action (1)
- hidradenitis suppurativa (1)
- hierarchical drift-diffusion modeling (1)
- hierarchical modeling (1)
- high dose dexamethasone suppression test (1)
- high intelligence (1)
- high tibial valgus osteotomy (1)
- high-accuracy 3D measurements (1)
- high-dose-rate brachytherapy boost (1)
- high-flow nasal cannula (1)
- high-intensity interval training (1)
- high-pressure freezing (1)
- high-sensitivity FEES (1)
- higher education (1)
- highly porous materials (1)
- hill numbers (1)
- hippocampal mossy fiber bouton (1)
- histones (1)
- historical document analysis (1)
- holotomography (1)
- homogeneous catalysis (1)
- homology modeling (1)
- homotypic fusion and protein sorting (1)
- honeybee (1)
- honeybees (1)
- hospitalization (1)
- host discrimination (1)
- host response (1)
- host selection (1)
- hotspot analysis (1)
- house dust mite allergy (1)
- human (1)
- human brain endothelium (1)
- human breast (1)
- human disturbance (1)
- human induced pluripotent stem cells (hiPSCs) (1)
- human pressure (1)
- human-centered AI (1)
- human-robot interaction (1)
- humanized mice (1)
- humanoid (1)
- humans (1)
- hyaluronan-related enzymes (1)
- hydraulic architecture (1)
- hydraulic conductivity (1)
- hydraulic efficiency (1)
- hydraulic variability (1)
- hydrazone (1)
- hydroboration (1)
- hydrogen storage (1)
- hydrological drought (1)
- hydroxy-dabrafenib (1)
- hymenoptera (1)
- hyper-IgM syndrome type 2 (HIGM2) (1)
- hyperbolic area (1)
- hypertension (1)
- hypophosphatasia (1)
- hypoxia (1)
- i.v. thrombolysis (1)
- iTotal (1)
- iatrogenic anemia (1)
- identification (1)
- identity defense (1)
- ideomotor theory (1)
- ileocecal resection (1)
- illusion of self-motion (1)
- image analysis (1)
- image processing (1)
- imaging changes (1)
- imaging techniques (1)
- imidazolate (1)
- immune control (1)
- immune impairment (1)
- immune therapy (1)
- immune-informatics (1)
- immunity (1)
- immunization (1)
- immunocytochemistry (1)
- immunodrug delivery (1)
- immunology (1)
- immunomodulation (1)
- immunonutrition (1)
- immunophenotyping (1)
- immunosorbents (1)
- impedance spectroscopy (1)
- implant design (1)
- implant survival (1)
- implantation (1)
- implementation (1)
- implicit association test (1)
- impulsive systems (1)
- in vitro model (1)
- in vitro-in vivo correlation (1)
- in vivo (1)
- in vivo experiments (1)
- in-bed cycling (1)
- incentives (1)
- incidental lifestyle physical activity (1)
- incisors (1)
- inclusion of nature in one’s self (1)
- indicator species (1)
- indigenous (1)
- individual case review (1)
- individual mobility (1)
- individual silicone bolus (1)
- individualized surgery (1)
- indoor dust (1)
- induced matching (1)
- induced pluripotent stem cell cardiomyocytes (1)
- inducible cyclooxygenase-2 (COX-2) (1)
- induction (1)
- infarction size (1)
- infection prevention (1)
- inferior vena cava (1)
- infinite-dimensional systems (1)
- inflammation marker (1)
- inflammatory bowel disease (1)
- inflammatory cascades (1)
- inflated fruiting calyx (1)
- infliximab (1)
- informal care (1)
- informal caregiving (1)
- information storage and retrieval (1)
- information systems and information technology (1)
- inherited peripheral neuropathy (1)
- inhibition (1)
- inhibitory postsynapse (1)
- inner ear (1)
- innervation (1)
- inorganic chemistry (1)
- inpatient rehabilitation (1)
- input-to-state stability (1)
- insect (1)
- insect brain (1)
- insect communities (1)
- insect decline (1)
- insect disturbance (1)
- insect-fungus symbiosis (1)
- insecticidal knockdown (1)
- instrument (1)
- insular cortex (1)
- insulin signaling (1)
- integrated stress response (1)
- integrators (1)
- integrin α5β1 (1)
- integrin αvβ3 (1)
- intelligent system (1)
- intelligent systems (1)
- intelligent virtual agents (1)
- intensive care unit (1)
- intentional action (1)
- intentional directions (1)
- interaction networks (1)
- interactive vegetation (1)
- interaural level difference (1)
- interaural time difference (1)
- interdisciplinary moral philosophy (1)
- interelectrode-distance (1)
- interferon beta-1a (1)
- interior and exterior acts (1)
- intermediate disturbance hypothesis (1)
- intermediate host (1)
- internalized stigmatization (1)
- internet of things (1)
- internet traffic (1)
- interstage aspiration (1)
- interventional procedures (1)
- interventional radiology (1)
- inter‐tegular distance (1)
- intestinal control (1)
- intra-annual time-series (1)
- intraabdominal abscess (1)
- intracerebral haemorrhage (1)
- intracranial hemorrhage (1)
- intraepidermal nerve fiber density (1)
- intragastric balloon (1)
- intravenous immunoglobulin (1)
- intraventricular therapy (1)
- intrinsic metabolism (1)
- introgressive hybridization (1)
- invasion (1)
- invasive electric stimulation (1)
- invasive fungal infection (1)
- invasive pulmonary aspergillosis (1)
- inversion (1)
- ion channel (1)
- ion channels (1)
- ionic liquids (1)
- irradiation (1)
- ischemia/reperfusion injury (1)
- ischemic penumbra (1)
- isocenter (1)
- isolation (1)
- isosteviol sodium (STVNA) (1)
- isotopes (1)
- isotopic labelling (1)
- isturisa (1)
- jaw bone (1)
- jaw clenching (1)
- jugular paraganglioma (1)
- juvenile hormone (1)
- juvenile progressive respiratory insufficiency (1)
- keratin-18 (1)
- key event relationship (1)
- kidney function (1)
- kinematics (1)
- kinetics (1)
- kinetin (1)
- kisspeptin/galanin/spexin signalling (1)
- knee joint (1)
- knee replacement (1)
- knockout (1)
- labor demand (1)
- labor market (1)
- lactic acidosis (1)
- laminopathy (1)
- land surface temperature (LST) (1)
- land use change (1)
- land use/cover pattern (LUCP) (1)
- landmark (1)
- landmark panorama (1)
- landscape diversity (1)
- language contact (1)
- language-image pre-training (1)
- large artery vasculitis (1)
- large loop excision of the transformation zone (LLETZ) (1)
- larval and pupal development (1)
- laser spectroscopy (1)
- laser surgery (1)
- late response (1)
- late-onset (1)
- latency type (1)
- lateral trochlear undercoverage (1)
- lava (1)
- lead (1)
- leaf (1)
- learning (1)
- learning and memory (1)
- learning arbitrary mappings (1)
- learning curve (1)
- left hemicolectomy (1)
- left ventricular ejection fraction (1)
- left ventricular performance (1)
- left-ventricular assist device (1)
- legislation (1)
- lepidoptera (1)
- leptomeningeal cells (1)
- lessons learned (1)
- lewis acid/base adducts (1)
- lewis superacid (1)
- lexical innovation (1)
- life events (1)
- life story (1)
- life-history traits (1)
- light-gated proteins (1)
- light‐gated (1)
- line notations (1)
- lineage differentiation (1)
- linear scaling (1)
- linker influence (1)
- lipid droplets (1)
- lipids (1)
- liposome (1)
- liquid chromatography/mass spectrometry (1)
- liraglutide (1)
- literature review (1)
- liver fibrosis (1)
- lncRNA (1)
- local cues (1)
- localization microscopy (1)
- locked shoulder dislocation (1)
- locomotion (1)
- locust outbreak (1)
- loess plateau (1)
- logistics (1)
- loneliness (1)
- long QT syndrome (1)
- long non-coding RNA (1)
- long-chain base (1)
- long-read sequencing (1)
- longitudinal decrease (1)
- longitudinal studies (1)
- loss (1)
- low back pain (1)
- low carb (1)
- low-grade mucinous neoplasm (1)
- low-risk intra-abdominal infections (1)
- lower extremity (1)
- lower grade glioma (1)
- luciferase (1)
- lyapunov methods (1)
- lymph node dissection (1)
- lymph nodes (1)
- lymphadenectomy (1)
- lymphocytes (1)
- lymphoma (1)
- lymphotoxicity (1)
- lysosomal disruption (1)
- lysosomal dysfunction (1)
- lysosomal enzyme (1)
- lysosomal storage disease (1)
- m exercise training (1)
- mRNA (1)
- mTORC1 (1)
- macrocycle (1)
- macrocycles (1)
- macrophage (1)
- macroscopic recurrence (1)
- macular neovascularization (1)
- magnetic compass (1)
- magnetic properties and materials (1)
- magnetoactive materials (1)
- main group element halides (1)
- major bleeding (1)
- major depression (1)
- major environmental values (1)
- major histocompatibility complex (1)
- male breast cancer (1)
- malnutrition (1)
- mammalian male germline (1)
- mammalian system (1)
- mannan (1)
- mapping (1)
- marginal gap formation (1)
- marine macroalgae (1)
- maser (1)
- mass casualties (1)
- mastocytosis (1)
- matched pair (1)
- maternal (1)
- maternal critical care (1)
- matrix metallopeptidase-1 (1)
- matrix metalloproteinase (1)
- maximum likelihood difference scaling (1)
- meadow (1)
- mean annual temperature (1)
- meaning (1)
- meaning-making (1)
- measels virus (1)
- measles virus (1)
- mechanical property (1)
- mechanical ventilator weaning (1)
- mechanisms (1)
- media equation (1)
- medial pivot (1)
- mediastinitis (1)
- medical data integration center (1)
- medical education (1)
- medical informatics initiative (1)
- medical nutrition therapy (1)
- medical students (1)
- medical therapy (1)
- medical-grade poly(ε-caprolactone) (1)
- medication-related osteonecrosis of the jaw (1)
- medicine (1)
- medieval manuscripts (1)
- medium-sized animals (1)
- medullary thyroid cancer (1)
- medulloblastoma (1)
- melanocytic markers (1)
- melanoma metastases (1)
- melt electrowriting (MEW) (1)
- membrane potential (1)
- memory B cells (1)
- meningeal blood-csf barrier (1)
- menues (1)
- merocyanine (1)
- merocyanines (1)
- mesenchymal stem cells (1)
- mesenchymal stromal cells (1)
- mesenteric stenting (1)
- meta-view (1)
- metabolic flux analysis (1)
- metabolic network model (1)
- metabolism and growth (1)
- metabotropic glutamate (mGlu) receptor (1)
- metacognitive competences (1)
- metagenomics (1)
- metal matrix (1)
- metal-free (1)
- metalloproteinase (1)
- metals (1)
- metamorphic buffer layer (1)
- metapopulation (1)
- metastasis-directed therapy (1)
- meteorological drought (1)
- methionine (1)
- methionine restriction (1)
- methyl viologen (1)
- methylation (1)
- methylphenidate (1)
- metyrapone (1)
- miR-182-5p (1)
- micro-computed tomography (1)
- micro-traumatic (1)
- microSPLiT (1)
- microbiological culture (1)
- microbiology (1)
- microbiomes (1)
- microbiota (1)
- microparticles (1)
- microphysiological systems (MPS) (1)
- microtubules (1)
- microvascular complications (1)
- microvascular endothelial cells (1)
- microvasculature (1)
- mid-infrared sensing (1)
- midbrain (1)
- midfrontal theta (1)
- migraine (1)
- migration (1)
- mild cognitive impairment (1)
- mindfulness (1)
- mineral trioxide aggregate (1)
- minimally invasive surgery (1)
- mitochondria function and morphology (1)
- mitochondrial DNA polymerase γ (1)
- mitochondrial FAO (1)
- mitotane (1)
- mixed infection (1)
- mixed-cultural (1)
- mobile health (1)
- mobile streaming (1)
- model (1)
- moderate-penetrance genes (1)
- modified Sugarbaker technique (1)
- moisture balance (1)
- molecular (1)
- molecular alterations (1)
- molecular docking (1)
- molecular graphs (1)
- molecular imaging (1)
- molecular mobility (1)
- molecular modeling (1)
- molecular orbitals (1)
- molecular representation (1)
- molecule isomorphism (1)
- monocyte (1)
- moral hazard (1)
- moral reasoning (1)
- moral responsibility (1)
- morphology (1)
- motion compensation (1)
- motion tracking (1)
- motivation (1)
- motor (1)
- motor control (1)
- motor neuron degeneration (1)
- motor neuropathy (1)
- mountain ecology (1)
- mountain ecosystems (1)
- mountain pines (1)
- mountains (1)
- mouse (1)
- movable sliding gantry (1)
- movement disorders (1)
- moving rubber hand illusion (1)
- mucin (1)
- mucosal healing (MH) (1)
- multi-organ chip (1)
- multi-tyrosine kinase inhibitor (1)
- multicenter (1)
- multichromophores (1)
- multicomponent stretching (1)
- multilayered skin (1)
- multimodal data (1)
- multimodal pain management (1)
- multiple brain metastases (1)
- multiple choice questions (1)
- multiple linear regression (1)
- multiscalar holotomography (1)
- multispectral data (1)
- multivariate Gaussian distribution (1)
- multivariate data analysis (1)
- multivariate quantile delta mapping (1)
- multivariate statistical process control (SPC) (1)
- multi‑center cohort study (1)
- muscle disease (1)
- muscle injury (1)
- muscle strength (1)
- mutational targeting (1)
- mycobacterial infection (1)
- mycophenolate (1)
- mycotoxin (1)
- myelination (1)
- myocardial work (1)
- nanoarchitecture (1)
- nanocellulose (1)
- nanogels (1)
- nanomedicine (1)
- nanopore (1)
- naphthalene diimide (1)
- narrow band imaging (NBI) (1)
- natural pest control (1)
- natural product hybrids (1)
- natural products (1)
- naturalistic stimuli (1)
- nature conservation (1)
- nausea and emesis (1)
- near infrared emitter (1)
- near infrared spectroscopy (1)
- necroptosis (1)
- nectar macronutrients (1)
- need satisfaction (1)
- negative affect (1)
- neglected groups (1)
- neisseria meningitidis (1)
- neoadjuvant (1)
- neoadjuvant therapy (1)
- neophyte trees (1)
- nerve agent (1)
- nerve compression (1)
- nervous system (1)
- nest site selection (1)
- nesting (1)
- network analysis (1)
- networked predictive control (1)
- neume notation (1)
- neural coding (1)
- neural network architecture (1)
- neuraminidase (1)
- neuro-/photoreceptor degeneration (1)
- neuroblastoma – diagnosis (1)
- neuroendocrine tumor (1)
- neurology (1)
- neurolysis (1)
- neuromelanin granules (1)
- neuromuscular junction (1)
- neuron (1)
- neuronal network (1)
- neurons (1)
- neuropeptide signalling (1)
- neuropeptides (1)
- neuroplasticity (1)
- neuroprotection (1)
- neuropsychiatric disorders (1)
- neurotrophic factor (1)
- neurotrophins (1)
- neurovasculature (1)
- next generation sequencing (1)
- next generation sequencing (NGS) (1)
- next-generation sequencing (1)
- niche (1)
- nitrate (1)
- nitric oxide (1)
- nitrite (1)
- nitrogen uptake (1)
- non-Lipschitz optimization (1)
- non-canonical translation (1)
- non-interventional (1)
- non-invasive ventilation (1)
- non-native accent (1)
- non-survivors (1)
- non-visual (1)
- nonhuman primates (1)
- nonlinear inverse problems (1)
- nonlinear systems (1)
- nonsmooth optimization (1)
- nonverbal communication (1)
- noradrenaline (1)
- noradrenaline transporter (1)
- norepinephrine transporter (1)
- northern Tanzania (1)
- nosocomial transmission (1)
- nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells (NFκB) (1)
- nucleic acid motifs (1)
- nucleolus (1)
- nucleosomes (1)
- nucleotide excision repair (1)
- nucleus (1)
- numerical finance (1)
- nurse bees (1)
- nurses (1)
- nutritional counseling (1)
- nutritional medical needs (1)
- nutritional risk screening (1)
- nycthemeral intraocular pressure (1)
- object detection (1)
- object-based image analysis (1)
- observation (1)
- observational (1)
- obstacle avoidance (1)
- obstetrics (1)
- occupation (1)
- octogenerians (1)
- octopamine receptors (1)
- offspring (1)
- oil spill (1)
- oilseed rape (1)
- older employees (1)
- oligodendrocyte (1)
- oligodendrocytes (1)
- oligodendroglioma (1)
- oligorecurrence (1)
- oligothiophene (1)
- oligothiophenes (1)
- olive (1)
- omega-3 fatty acid (1)
- omega-6 fatty acid (1)
- omics (1)
- oncodermatology (1)
- oncology outpatients (1)
- oogenesis (1)
- open abdomen (1)
- open spaces (1)
- openEHR (1)
- operating platform (1)
- operative planning (1)
- optic flow (1)
- optical (1)
- optical diversity (1)
- optical materials (1)
- optical underwater 3D sensor (1)
- oral (1)
- oral health (1)
- oral microbiome (1)
- oral nutrition supplements (1)
- oral-health-related quality of life (1)
- ordinary differential equations (1)
- organic light emitting diodes (1)
- organic photodiodes (1)
- organic solar cells (1)
- organic synthesis (1)
- organocatalytic (1)
- organoid (1)
- organotypic hippocampal slice cultures (OHSC) (1)
- orientation (1)
- origin (1)
- oro-antral communication (1)
- oro-antral fistula (1)
- oroantral fistula (1)
- orofacial granulomatosis (1)
- orthopoxvirus (1)
- oscillating biomagnetic fields (1)
- osilodrostat (1)
- osmotic stress (1)
- osteogenic differentiation (1)
- osteogenic potential (1)
- osteoporosis (1)
- osteosynthesis (1)
- outbreak (1)
- outcome prediction (1)
- outer hair cell (OHC) (1)
- outreach (1)
- over-determined problem (1)
- overall survival (1)
- overfishing (1)
- overwork (1)
- oxime (1)
- oxytosis/ferroptosis (1)
- p.R245H (1)
- p.S298P (1)
- p53 (1)
- p97/VCP (1)
- pain-associated behavior (1)
- paleoecology (1)
- paleogeography (1)
- palladium (1)
- palliative care (1)
- palynology (1)
- pancreatic adenocarcinoma (PDAC) (1)
- pancreatic neoplasms (1)
- pancreatic surgery (1)
- pangolin (1)
- panorama (1)
- par-seqFISH (1)
- parastomal hernia (1)
- parathyroid adenoma (1)
- parathyroid hormone 1 receptor (1)
- parenteral nutrition (1)
- parents (1)
- parthenogenesis (1)
- partial correlation (1)
- partial deafness treatment (1)
- partial least square regression (1)
- participation in clinical trials (1)
- particulate matter (1)
- passage of time (1)
- pasture (1)
- patellofemoral relationship (1)
- paternal (1)
- paternal age effect (1)
- path analysis (1)
- path integration (1)
- pathogenesis (1)
- pathogenic TP53 germline variant (1)
- pathway analysis (1)
- patient (1)
- patient access (1)
- patient blood management (1)
- patient reported outcome measures (1)
- patient safety (1)
- patient serum (1)
- patient-reported outcomes (1)
- patient-specific (1)
- patient–physician relationship (1)
- pectoralis major transfer (1)
- pediatric adrenocortical cancer (1)
- pediatric adrenocortical carcinoma (1)
- pediatric adrenocortical tumor (1)
- pediatrics (1)
- pedunculopontine nucleus (PPN) (1)
- pegylated insulin-like growth factor 1 (1)
- pemphigus foliaceus (1)
- pemphigus vulgaris (1)
- penetrating ileitis (1)
- penicillin allergy (1)
- penicillin hypersensitivity (1)
- pension reform (1)
- pentacene (1)
- peptide backbone (1)
- peptide fragment (1)
- peptide receptor radionuclide therapy (1)
- peptide tyrosine tyrosine (PYY) (1)
- peptide tyrosine tyrosine 3-36 (PYY\(_{3-36}\)) (1)
- peptides (1)
- percussion core probing (1)
- performance (1)
- performance monitoring (1)
- perfusion culture (1)
- perianal fistulas (1)
- perinatal (1)
- periodontal disease (1)
- periodontal therapy (1)
- perioperative antibiotic prophylaxis (1)
- perioperative therapy (1)
- peripartum (1)
- peripheral nerve (1)
- peripheral nerve involvement (1)
- periphery-brain interactions (1)
- periprosthetic infection (1)
- periprosthetic joint infection (1)
- peritoneal metastasis (1)
- peritonitis (1)
- periurban (1)
- permafrost (1)
- peroxisome (1)
- personalised medicine (1)
- personalised orthopaedic implantation (1)
- personality traits (1)
- personalized medicine (1)
- perturbation (1)
- perylene dyes (1)
- perylenebisimide (1)
- petal (1)
- phage (1)
- phagocytes (1)
- phalloidin stain (1)
- pharmacotherapy (1)
- pharmacovigilance (1)
- phase I (1)
- phase II (1)
- phenomenology of acting and willing (1)
- phenotypic plasticity (1)
- phenprocoumon (1)
- pheochromocytoma/paraganglioma (1)
- pheromone trail (1)
- philanthidae (1)
- phlorizin (1)
- phosphatidyl-inositol-3-kinase p110 alpha (1)
- phosphatidylinositol (1)
- phosphatidylserine (1)
- phosphoantigen (1)
- phosphodiesterase (1)
- phosphodiesterase-4 (1)
- phosphodiesterase-inhibitors (1)
- phosphoglycolate phosphatase (1)
- phospholipase C gamma 2 (1)
- phosphorylated tau protein (1)
- phosphorylation (1)
- photo-crosslinking (1)
- photodynamic therapy (1)
- photoluminescence (1)
- photolyase (1)
- photon counting (1)
- photon‐correlation (1)
- photoplethysmography (1)
- photopolymerization (1)
- photoreflectance (1)
- photosensor (1)
- photothrombosis (1)
- phototropin (1)
- physical education (1)
- physical examination (1)
- physical fitness (1)
- physical health (1)
- physicochemical characterization (1)
- physiologically based pharmacokinetic (PBPK) modeling (1)
- physiology (1)
- phytohormones (1)
- pituitary (1)
- pityriasis rubra pilaris (1)
- placement (1)
- plan sciences (1)
- plant cuticle (1)
- plant guilds (1)
- plant richness (1)
- plant sphingolipid metabolism (1)
- plant system (1)
- plant–insect interactions (1)
- plant–pollinator interactions (1)
- plasma (1)
- plasma NMR (1)
- plasticity (1)
- plasticizers (1)
- platelet activation (1)
- platelet inhibition (1)
- platelet physiology (1)
- platelet receptors (1)
- platelet responsiveness (1)
- platelet-rich fibrin (1)
- platform economy (1)
- platinum (1)
- platinum complexes (1)
- plausibility (1)
- podocytes (1)
- point cloud (1)
- pointing gestures (1)
- pointing motives (1)
- polar ion transport (1)
- pollen (1)
- pollen nutrients (1)
- pollination (1)
- pollination network (1)
- pollination services (1)
- pollinator (1)
- pollinator decline (1)
- pollinator diversity (1)
- pollution (1)
- poly(ADP-ribose) polymerase inhibitors (1)
- poly(lactide-co-glycolide) (1)
- polycaprolactone (1)
- polycarbonates (1)
- polycationic peptides (1)
- polyethylene glycol (1)
- polygenic risk score (1)
- polymer electrolytes (1)
- polymers (1)
- polymethylmethacrylate (1)
- polymorphisms (1)
- polynomial chaos (1)
- polyp (1)
- polypeptoids (1)
- pontryagin maximum principle (1)
- population inversion (1)
- population pharmacokinetics (1)
- population-based studies (1)
- posaconazole (1)
- positive affect (1)
- positive selection (1)
- post-error slowing (1)
- post-translational modifications (1)
- postcardiotomy shock (1)
- posterior cruciate ligament (1)
- posterior tibial slope (1)
- postmortem (1)
- postnatal depression (1)
- postoperative inflammation (1)
- postoperative rehabilitation (1)
- postpolymerization modification (1)
- postural control (1)
- posturomed (1)
- post‐truth (1)
- potentiation (1)
- poxvirus (1)
- practical reasoning (1)
- pre-error speeding (1)
- preanalytical conditions (1)
- precipitation (1)
- precision horticulture (1)
- precision oncology (1)
- precision-cut lung slices (1)
- preclinical research (1)
- predation stress (1)
- predictive modeling (1)
- prefabricated granules (1)
- prehabilitation (1)
- preoperative planning (1)
- presence (1)
- prestyloid recess (1)
- presynaptic (1)
- presynaptic ER dynamics (1)
- presynaptic homeostasis (1)
- presynaptic inhibition (1)
- prevention (1)
- primary aldosteronism (1)
- primary aromatic amine (1)
- primary care (1)
- primary cutaneous follicular B-cell lymphoma (1)
- primary hyperparathyroidism (1)
- pristine forests (1)
- pro-inflammatory cytokines (1)
- probabilistic reversal learning (1)
- professional image enhancement technique (PIET) (1)
- progeria (1)
- prognostic awareness (1)
- prognostic marker (1)
- prognostic markers (1)
- programmed cell death receptor-1 (1)
- proliferation (1)
- prompt engineering (1)
- propensity score matching (1)
- prosociality (1)
- prospective (1)
- prostate adenocarcinoma (1)
- prostate-specific antigen (1)
- prostate-specific membrane antigen (1)
- prosthetic dentistry/prosthodontics (1)
- prosthetic design (1)
- protected areas (1)
- protection status (1)
- protein (1)
- protein alkylation (1)
- protein chip (1)
- protein corona (1)
- protein kinase (1)
- protein kinase pathway (1)
- protein phosphorylation (1)
- protein sensing (1)
- protein variant (1)
- proteomic (1)
- proton beam therapy (1)
- prototheca (1)
- proximal gradient method (1)
- proximal humeral fracture (1)
- proximity labeling (1)
- proximity ligation (1)
- psychiatric disorders (1)
- psycho-oncology (1)
- psychological capital (1)
- psychophysics (1)
- psychosocial (1)
- psychotropic medications (1)
- pubic symphysis (1)
- public health (1)
- public health preparedness (1)
- public speaking (1)
- pull effect (1)
- pulmonary artery pressure (1)
- punctate mechanical allodynia (1)
- purine derivatives (1)
- push–pull thienylthiazole (1)
- python (1)
- qualitative approaches (1)
- quantitative MRI (1)
- quantum dot (1)
- quartz-pebble conglomerate (1)
- questionnaire development (1)
- quinoa (1)
- quinolones (1)
- quinone (1)
- radar data (1)
- radial forearm flap (1)
- radical (1)
- radical cystectomy (1)
- radical reactions (1)
- radiochemistry (1)
- radiography (1)
- radiology (1)
- radiopharmaceuticals (1)
- radiotracer (1)
- radiotracer kinetics (1)
- random forest classification (1)
- random forest modeling (1)
- randomized controlled trial (1)
- range limits (1)
- rare diseases (1)
- rat study (1)
- rationalization (1)
- rats (1)
- re-induction (1)
- re-irradiation (1)
- real laboratory (1)
- real world data (1)
- real world evidence (1)
- real-world application (1)
- real-world data (1)
- rearranged during transfection (1)
- reasoning biases (1)
- recapitulation (1)
- receptors (1)
- recommender agent (1)
- reconstruction (1)
- recurrence (1)
- recurrent (1)
- red blood cell transfusion (1)
- red blood cells (1)
- regeneration (1)
- regenerative capacity (1)
- regenerative potential (1)
- region of interest (1)
- regional cerebral oxygenation saturation (1)
- regional climate model (RCM) (1)
- regional transient osteoporosis (1)
- registry (1)
- regulatory T-cell (Treg) (1)
- rehabilitation (1)
- reinforcement learning (1)
- reintroduction (1)
- relapse (1)
- religion (1)
- religiosity (1)
- remote care/telehealth (1)
- remote monitoring (1)
- renal function (1)
- renal inflammation (1)
- reoxygenation (1)
- repair (1)
- replication stress (1)
- reporting and data system (1)
- reproducibility (1)
- reproductive toxicity (1)
- research (1)
- resident memory T cells (1)
- resource selection (1)
- respiratory chain (1)
- respiratory failure (1)
- response durability (1)
- response modalities (1)
- response surface (1)
- response-time analysis (1)
- responsivity (1)
- restaurants (1)
- restrictive cardiomyopathy (1)
- retina (1)
- retinal angiomatous proliferation (1)
- retinitis pigmentosa (1)
- retranslational research (1)
- revision arthroplasty (1)
- reward positivity/FRN/MFN/N2 (1)
- rhabdoid differentiation (1)
- rhabdoid melanoma (1)
- rheumatoid arthritis (1)
- rhodamine–phalloidin stain (1)
- rhodopsin phosphodiesterase (RhoPDE) (1)
- ribosome (1)
- rich vehicle routing problem (1)
- right-left comparison (1)
- ring opening reactions (1)
- ring-opening polymerization (1)
- risk assessment (1)
- risk factor (1)
- risk prediction scores (1)
- risk score (1)
- risks (1)
- risperidone (1)
- rituximab (1)
- road traffic (1)
- robot (1)
- robot-supported training (1)
- robotic surgery (1)
- robotic tutor (1)
- robustness (1)
- role of mathematics in STEM (1)
- room-temperature phosphorescence (RTP) (1)
- root-canal treatment (1)
- rove beetle (1)
- rt-PA (1)
- rule retrieval (1)
- ruxolitinib (1)
- sRNA biogenesis (1)
- sSupramolecular interaction (1)
- saccotomy (1)
- sacrifice (1)
- safety (1)
- safety behavior (1)
- safety-efficiency trade-off (1)
- salicylic acid (1)
- salience theory (1)
- saliency maps (1)
- salt tolerance (1)
- salvage (1)
- saproxylic beetles (1)
- sarcoglycanopathy (1)
- sarcoma (1)
- satellite data (1)
- satellitosis (1)
- satisfaction with life (1)
- scaffold (1)
- scapula (1)
- scapula alata (1)
- scapular winging (1)
- scheduling (1)
- school (1)
- school statistics (1)
- school-based prevention (1)
- schoolchildren (1)
- science, technology and society (1)
- scoliosis (1)
- scoping review (1)
- screening (1)
- seasonal (1)
- seasonality (1)
- secondary education (1)
- secondary reconstruction (1)
- secondary wound dressing (1)
- sectoral planning (1)
- secure group communication (1)
- sedimentology (1)
- segmental centers of mass (1)
- selective mutism (1)
- selenolysis (1)
- self-deception (1)
- self-help (1)
- self-infliction (1)
- self-injury (1)
- self-organization (1)
- semantic change (1)
- semantic interoperability (1)
- semantic segmentation (1)
- semigroup of holomorphic functions (1)
- senescence‐associated secretory phenotype (1)
- sensitivity and specificity (1)
- sepsis (1)
- septic (1)
- septic shock (1)
- sequential quadratic hamiltonian method (1)
- serotonin (1)
- serotonin transporter (1)
- serratus anterior (1)
- serum concentration (1)
- serum retention (1)
- settlement growth (1)
- sex (1)
- sex chromosomes (1)
- sex differences (1)
- sex hormone (1)
- sex linked pigmentation pattern (1)
- sex pheromones (1)
- sex-determining genes. (1)
- sexual and spiritual abuse (1)
- sexual antagonistic genes (1)
- sexual development dysgenesis (1)
- sexual dimorphism (1)
- shade cover (1)
- shape (1)
- shear wave elastography (1)
- shedding (1)
- shock (systemic, cardiac or circulatory) (1)
- short-chain fatty acids (1)
- short‑term refrigeration (1)
- shoulder (1)
- shoulder arthroplasty (1)
- shoulder injuries (1)
- side-effects (1)
- signal to noise ratio (1)
- signal voids (1)
- silicon vacancy (1)
- silyl selenides (1)
- silyl sulfides (1)
- simulated digestion (1)
- simultaneous integrated boost (1)
- single photon emission (1)
- single photon emission computed tomography (SPECT) (1)
- single-cell RNA-seq (1)
- single-electron transistors (1)
- single-photon detectors (1)
- single-port appendectomy (1)
- single-sided deafness (1)
- sitting (1)
- skilled forelimb movements (1)
- skin (1)
- skin punch biopsy (1)
- skin squamous cell carcinoma (1)
- skin-to-skin contact (1)
- sleep (1)
- sleep/activity (1)
- sleeve gastrectomy (1)
- small animal (1)
- small-fiber neuropathy (1)
- smart charging (1)
- smart grid (1)
- smart speakers (1)
- smart-phone (1)
- smartwatch (1)
- snow cover area (1)
- snow cover depletion (1)
- social VR (1)
- social attention (1)
- social avoidance (1)
- social cognition (1)
- social cues (1)
- social decision-making (1)
- social distancing (1)
- social identity (1)
- social interaction (1)
- social isolation (1)
- social media (1)
- social motives (1)
- social neuroscience (1)
- social robot (1)
- social robotics (1)
- social support (1)
- socially interactive agents (1)
- sociomotor control (1)
- sodium alginate (1)
- software library (1)
- soil water content (1)
- sol-gel chemistry (1)
- solid-state NMR (1)
- solitary bees (1)
- soluble endoglin (1)
- solvatochromism (1)
- solvent effects (1)
- somatic hypermutation (1)
- somatic mutations (1)
- sound localization (1)
- sown flower field age and size (1)
- space-for-time approach (1)
- spacer (1)
- spatial analysis (1)
- spatial planning (1)
- spatial scales (1)
- spatially structured population (1)
- spatio-temporal analysis (1)
- special schools (1)
- species (1)
- species community composition (1)
- species distribution modeling (1)
- species richness (1)
- species-specific epigenetic marks (1)
- spectral diversity (1)
- spectral karyotyping (1)
- spectral mixture analysis (1)
- spectral statistics (1)
- spectral variation hypothesis (1)
- spectrophotometer (1)
- sperm DNA methylation (1)
- sphingolipid (1)
- sphingosine kinase inhibitor SKI-II (1)
- spillovers (1)
- spin lock (1)
- spin polarization (1)
- spin-lock (1)
- spinal dorsal horn (1)
- spiral ganglion neuron (1)
- spiritual communities (1)
- spontaneous network activity (1)
- spontaneous pneumomediastinum (1)
- spontaneous pneumopericardium (1)
- sport geography (1)
- sport medicine (1)
- spray‐drying (1)
- squamous tumors (1)
- stability (1)
- stable isotope breath tests (1)
- staging (1)
- stalk cell (1)
- standardized analysis method (1)
- standardized reporting system (1)
- staphylocccal infection/epidemiology (1)
- starazine (1)
- starphene analogue (1)
- statin (1)
- steatosis (1)
- stem cell niche (1)
- stenosis (1)
- stent (1)
- stent retriever (1)
- stent-retriever device (1)
- stereology (1)
- stereoselective (1)
- stereotactic irradiation (1)
- stereotypes (1)
- stibinidenes (1)
- stimulated emission (1)
- stock markets (1)
- stomatognatic system (1)
- store-operated Ca2+ entry (1)
- strain elastography (1)
- stress fibers (1)
- stress granules (1)
- stress response (1)
- striatum (1)
- stroke care (1)
- stromal hyaluronan (1)
- stromal tissues (1)
- strong coupling (1)
- structural changes (1)
- structural dynamics (1)
- structural elucidation (1)
- structure (1)
- structure activity (1)
- structure elucidation (1)
- structure prediction (1)
- structured illumination (1)
- structured physical activity (1)
- student performance (1)
- study (1)
- study design (1)
- su-schrieffer-heeger (SSH) models (1)
- sub-pixel coastline extraction (1)
- subcutaneous animal model (1)
- substantia nigra pars compacta (1)
- substituent (1)
- subthalamic nucleus (1)
- subthalamic nucleus (STN) (1)
- successive approximations strategy (1)
- summer precipitation regions (1)
- sun exposure (1)
- sunburn (1)
- super-obesity (1)
- superconducting instability (1)
- superradiance (1)
- supervisors (1)
- supine hypotensive syndrome (1)
- suppressive function (1)
- supramolecular chemistry (1)
- supraparticles (1)
- surface dose measurement (1)
- surface structure (1)
- surface urban heat island (SUHI) (1)
- surface water (1)
- surface water area (1)
- surgical drainage (1)
- surgical management (1)
- surgical management of paraganglioma (1)
- surgical manipulator (1)
- surgical site infection (1)
- surgical therapy (1)
- survey instrument (1)
- survival (1)
- sustainability teaching (1)
- sustainable energy source (1)
- sustainable lifestyles (1)
- swarming (1)
- switching (1)
- synapse (1)
- synaptic inhibition (1)
- synaptic ultrastructure (1)
- synthesis (1)
- synthetic aperture RADAR (1)
- system transparency (1)
- systemic effects (1)
- systemic reviews (1)
- systemic therapy (1)
- systems biology (1)
- t-SNE (1)
- tMCAO (1)
- target validation (1)
- targeted combination therapy (1)
- targeted sequencing (1)
- targeted therapies (1)
- targeted therapy (1)
- targeted treatment (1)
- task allocation (1)
- task switching (1)
- tautomerization (1)
- taxane (1)
- teaching materials (1)
- teaching quality (1)
- technology acceptance (1)
- technology-supported education (1)
- technology-supported learning (1)
- teeth (1)
- teeth extraction (1)
- telemedicine network (1)
- temperate forests (1)
- temperature (1)
- temperature gradient (1)
- temporal bone (1)
- temporal range (1)
- temporal statistics (1)
- tendon (1)
- ternary organic solar cells (1)
- terror attacks (1)
- testing-method consensus (1)
- testosterone (1)
- tethering (1)
- tetracoordinated boron (1)
- tetraspanin (1)
- text supervision (1)
- texture analysis (1)
- the sacred (1)
- theoretical and contrastive linguistics (1)
- theory (1)
- therapeutic application (1)
- therapeutic drug monitoring (1)
- thermal point cloud (1)
- thermal rearrangement (1)
- thermodynamics (1)
- thermoelectric characterization (1)
- thermoelectric generators (1)
- thiol-ene (1)
- thiolysis (1)
- thiosemicarbazone (1)
- thorax (1)
- threat (1)
- three-dimensional imaging (1)
- three-dimensional printing (1)
- three-point bending (1)
- threshold indicator taxa analysis (1)
- thrombo-inflammation (1)
- thrombus (1)
- thrust vector control (1)
- thulium telluride (1)
- thymocytes (1)
- thyroid gland (1)
- thyroid hormone (1)
- thyroiditis (1)
- tibial rotation (1)
- tight junctions (1)
- tight-binding (1)
- time geography (1)
- time series analysis (1)
- time-resolved impulsive stimulated raman spectroscopy (1)
- titanium trauma splint (TTS) removal (1)
- tocilizumab (1)
- toll-like receptors (1)
- tongue pressing (1)
- tooth discoloration (1)
- tooth extraction (1)
- tooth loss (1)
- topography (1)
- topological insulators (1)
- topological phase transitions (1)
- topological states (1)
- total hip arthroplasty (1)
- total knee replacement (1)
- totally implantable venous access port (1)
- trabectedin (1)
- tracheotomy (1)
- training (1)
- trait activation in two-stage ultimatum game, (1)
- trait emotional intelligence (1)
- trametinib (1)
- tranexamic acid (1)
- trans-tango (1)
- transcranial direct current stimulation (1)
- transcription factors (1)
- transcriptional control (1)
- transcriptional regulation (1)
- transcriptome (1)
- transcriptomes (1)
- transcriptomic analysis (1)
- transcriptomic response (1)
- transforming growth factor-beta 1 (1)
- transfusion (1)
- transgenic mice (1)
- transient absorption (1)
- transient bursting (1)
- transient regulatory T-cell targeting (1)
- transition metal dichalcogenide (1)
- transition metal dichalcogenides (1)
- transition metal oxides (1)
- translation (1)
- transmission (1)
- transparent matrix (1)
- transporter (1)
- transportome (1)
- trans‐Tango (1)
- trap selectivity (1)
- traumatic brain injury (1)
- treatment (1)
- treatment benefit (1)
- treatment outcome (1)
- treatment plan (1)
- treatment resistance (1)
- trends (1)
- triage (1)
- trial protocol (1)
- triangle method (1)
- triangular fibrocartilage complex (1)
- triarylborane (1)
- triazolotriazine derivatives (1)
- tricompartmental knee osteoarthritis (1)
- triglycerides (1)
- triplet (1)
- triplet sensitization (1)
- truck detection (1)
- trust (1)
- tryptophan hydroxylase-2 (Tph2) (1)
- tubular constructs (1)
- tumor (1)
- tumor microenvironment (1)
- tumor model systems (1)
- tumor necrosis factor alpha (1)
- tumor slice cultures (1)
- tumor-associated hyaluronan staining pattern (1)
- two-dimensional materials (1)
- two-dimensions (1)
- two-photon absorption (1)
- two-stage ultimatum game (1)
- two‐sided markets (1)
- two‑layer feedforward networks (1)
- tympanic paraganglioma (1)
- tympanojugular paraganglioma (1)
- tyrosine kinase (1)
- tyrosine-kinase inhibitor (1)
- ubiquitination (1)
- ultrafast Raman loss spectroscopy (1)
- ultrasound imaging (1)
- uncertain volatility (1)
- uncertainty quantification (1)
- unconventional superconductivity (1)
- under-dosing (1)
- undernourishment (1)
- undersampling (1)
- unexpressed needs (1)
- unfolded protein response (1)
- unilateral hearing loss (1)
- universal prevention (1)
- unmanned aerial vehicles (1)
- urban (1)
- urban climate (1)
- urban ecology (1)
- urban modelling (1)
- uremic toxins (1)
- urgent surgery (1)
- user acceptance (1)
- uveal melanoma (1)
- vaccination (1)
- vaccine hesitancy (1)
- vancomycin (1)
- variable regions (1)
- variant (1)
- vasa vasorum (1)
- vascular access (1)
- vascular homeostasis (1)
- vascularized scaffold (1)
- vasculogenesis (1)
- vection (1)
- vegetation indices (1)
- vegetation restoration (1)
- vemurafenib (1)
- verbal humor (1)
- vertebral artery (1)
- verteporfin (1)
- vertical stratification (1)
- vessel diameter (1)
- vessel tapering (1)
- vestibular (1)
- vestibular aqueduct (VA) (1)
- vibrational coherence (1)
- vigorous intermittent lifestyle physical activities (1)
- viral infection (1)
- viral pathology (1)
- virtual (1)
- virtual agent (1)
- virtual body ownership (1)
- virtual docking (1)
- virtual hand illusion (1)
- virtual human (1)
- virtual noncalcium imaging (1)
- virtual stimuli (1)
- virtual tunnel (1)
- virulence (1)
- virus (1)
- viruses (1)
- visual activity (1)
- visual clustering (1)
- visual pathways (1)
- visual system (1)
- visualization of technology (1)
- vitamin C (1)
- vitamin D receptor (1)
- vitamin D3 (cholecalciferol, VD3) (1)
- volcanoes (1)
- voltage-gated Na\(^+\) channel (1)
- volume (1)
- volume clamp (1)
- volume regulation (1)
- volumetric absorptive micro-sampling (VAMS) (1)
- volumetric modulated arc therapy (VMAT) (1)
- vulnerability (1)
- vulnerability paradox (1)
- vulnerance (1)
- walking (1)
- water (1)
- wax composition (1)
- weak coupling (1)
- wearable (1)
- weight bearing line (1)
- well-being (1)
- white blood cell count (1)
- white matter hyperintensities (1)
- whole genome sequencing (1)
- whole genome sequencing (WGS) (1)
- whole-exome sequencing (1)
- wild honeybees (1)
- wood anatomy (1)
- wood density (1)
- word-formation (1)
- workflow (1)
- wound (1)
- wound healing (1)
- wound infection (1)
- x-ray computed (1)
- yoga (1)
- younger employees (1)
- zebrafish (1)
- zircon geochronology (1)
- zoledronic acid (1)
- zygomorphy (1)
- α-Particle (1)
- α-synuclein-specific T cells (1)
- α‐diversity (1)
- β-actin mRNA (1)
- β-adrenergic receptors (1)
- βAR (1)
- β‐diversity (1)
- γ-H2AX (1)
- γδ T cell (1)
- γδ T cells (1)
- π-extension (1)
- “other-power” (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (106)
- Medizinische Klinik und Poliklinik I (50)
- Neurologische Klinik und Poliklinik (50)
- Medizinische Klinik und Poliklinik II (48)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (41)
- Institut für Geographie und Geologie (39)
- Institut für Informatik (35)
- Comprehensive Cancer Center Mainfranken (34)
- Klinik und Poliklinik für Nuklearmedizin (32)
- Lehrstuhl für Orthopädie (32)
Sonstige beteiligte Institutionen
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (5)
- Bernhard-Heine-Centrum für Bewegungsforschung (4)
- Zentraleinheit Klinische Massenspektrometrie (3)
- Krankenhaushygiene und Antimicrobial Stewardship (Universitätsklinikum) (2)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (2)
- Arizona State University, Tempe, Arizona, USA (1)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (1)
- Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, Göttingen (1)
- Datenintegrationszentrum Würzburg (DIZ) (1)
- Department of Cellular Biochemistry, University Medical Centre Göttingen (1)
- Department of Molecular Biology, University Medical Centre Göttingen (1)
- Fraunhofer-Institute for Applied Optics and Precision Engineering IOF Jena, Germany (1)
- Friedrich Schiller University Jena, Germany (1)
- Göttingen Center for Molecular Biosciences, University of Göttingen (1)
- Helmholtz Institute for RNA-based Infection Biology (HIRI), Josef-Schneider-Straße 2/D15, DE-9708 Wuerzburg, Germany (1)
- Interdisziplinäre Biomaterial- und Datenbank Würzburg (ibdw) (1)
- Krankenhaushygiene und Antimicrobial Stewardship (1)
- Krankenhaushygiene und Antimicrobial Stewardship, Universitätsklinikum Würzburg (1)
- Lehrstuhl für Regeneration Muskuloskelettaler Gewebe (1)
- Lehrstuhl für Röntgenmikroskopie (1)
- Max Planck School of Photonics Jena, Germany (1)
- Mildred-Scheel-Nachwuchszentrum (1)
- Muskuloskelettales Centrum Würzburg (MCW) (1)
- National Institute for Materials Science, Tsukuba, Japan (1)
- Professional School of Education (1)
- Service Centre InterNational Transfer (Universität Würzburg) (1)
- Servicezentrum Medizin-Informatik (1)
- Technische Universität Dortmund, Fakultät für Informatik, Computer Graphics Group (1)
- University of Oldenburg, Germany (1)
- University of Science and Technology of China, Hefei, China (1)
- Würzburg-Dresden Cluster of Excellence ct.qmat (1)
- Zentrallabor, Universitätsklinikum Würzburg (1)
- Zentrum für soziale Implikationen künstlicher Intelligenz (SOCAI) (1)
Cisplatin is a commonly used chemotherapeutic agent; however, its potential side effects, including gonadotoxicity and infertility, are a critical problem. Oxidative stress has been implicated in the pathogenesis of cisplatin-induced testicular dysfunction. We investigated whether kinetin use at different concentrations could alleviate gonadal injury associated with cisplatin treatment, with an exploration of the involvement of its antioxidant capacity. Kinetin was administered in different doses of 0.25, 0.5, and 1 mg/kg, alone or along with cisplatin for 10 days. Cisplatin toxicity was induced via a single IP dose of 7 mg/kg on day four. In a dose-dependent manner, concomitant administration of kinetin with cisplatin significantly restored testicular oxidative stress parameters, corrected the distorted sperm quality parameters and histopathological changes, enhanced levels of serum testosterone and testicular StAR protein expression, as well as reduced the up-regulation of testicular TNF-α, IL-1β, Il-6, and caspase-3, caused by cisplatin. It is worth noting that the testicular protective effect of the highest kinetin dose was comparable/more potent and significantly higher than the effects of vitamin C and the lowest kinetin dose, respectively. Overall, these data indicate that kinetin may offer a promising approach for alleviating cisplatin-induced reproductive toxicity and organ damage, via ameliorating oxidative stress and reducing inflammation and apoptosis.
Readers use prior knowledge to evaluate the validity of statements and detect false information without effort and strategic control. The present study expands this research by exploring whether people also non-strategically detect information that threatens their social identity. Participants (N = 77) completed a task in which they had to respond to a “True” or “False” probe after reading true, false, identity-threatening, or non-threatening sentences. Replicating previous studies, participants reacted more slowly to a positive probe (“True”) after reading false (vs. true) sentences. Notably, participants also reacted more slowly to a positive probe after reading identity-threatening (vs. non-threatening) sentences. These results provide first evidence that identity-threatening information, just as false information, is detected at a very early stage of information processing and lends support to the notion of a routine, non-strategic identity-defense mechanism.
Objectives
Handball is associated with a high risk of overuse shoulder injury. This study investigated if an injury prevention programme effectively reduces overuse injury to the throwing shoulder of handball athletes.
Methods
61 men’s and women’s handball teams (u-19 and senior athletes) were cluster-randomised into an intervention and a control group in the 2019–2020 season. Players of the intervention group regularly carried out an injury prevention programme. Both groups documented overuse shoulder injuries via an online questionnaire every second week. The primary endpoint was the prevalence of overuse injury to the throwing shoulder. Secondary endpoints were the influence of compliance on the primary endpoint and intensity of overuse shoulder symptoms measured by a shortened, handball-specific Western Ontario Shoulder Index (WOSI).
Results
31 teams (295 players) in the intervention group and 30 teams (284 players) in the control group were included for analyses. The overall questionnaire response rate was 61%. The average prevalence of overuse shoulder injury did not significantly differ between the intervention group (n=109, 38.4% (95% CI 32.9% to 44.2%)) and the control group (n=106, 35.9% (95% CI 30.7% to 41.6%), p=0.542). Compliance with the intervention programme did not significantly affect overuse shoulder injury (p=0.893). Using generalised estimating equations for WOSI, the estimated mean for the intervention group was 44.6 points (95% CI 42.0 to 47.1) and 47.6 points for the control group (95% CI 44.9 to 50.3, p=0.111).
Conclusions
A multicomponent exercise programme using rubber bands and stretching did not significantly reduce the prevalence or symptoms of overuse throwing shoulder injury in handball athletes of both sexes. Randomised controlled study; level of evidence I.
To date, no consensus exists regarding the best surgical management of isolated, micro-traumatic long thoracic nerve (LTN) paresis. Our hypothesis was that a combined decompression of the LTN at two potential locations for entrapment would be effective in the management of dynamic LTN paresis. We report on twelve patients with isolated LTN parersis, with tenderness at two entrapment sites, who underwent bifocal LTN decompression after undergoing unsuccessful conservative treatment for at least 6 months; all patients had preoperative electrodiagnostic studies that confirmed the paresis and ruled out peripheral neuritis. Clinical and electrical improvements were observed in eight patients (67%) regarding shoulder flexion, shoulder abduction, and Quick-DASH scores. Four patients (33%) did not improve after surgery. The results corroborate our hypothesis that a bifocal LTN decompression can be an effective and reliable therapeutic option in more than half of a very selective patient population suffering from serratus anterior muscle deficiency.
We quantify the contemporaneous relationships among stock markets in the euro area, the United States, and a group of emerging economies over the period from 2008 to 2017. Exploiting the heteroskedasticity in the stock market data, we identify shocks that originated in the respective domestic markets and shocks that are common to all markets. Our results underline the leading role of the United States in international equity markets, but also point to the importance of indirect spillovers for all economies. Variance decompositions show that while domestic shocks explain the bigger part of the variation in each stock market, a substantial part of the variation in the euro area and the emerging economies can be attributed to foreign shocks. A comparison with a sample covering the pre‐crisis period from 1999 to 2007 suggests a strengthening of the linkages among global stock markets in recent years. In particular, the spillovers from advanced to emerging economies have become more pronounced.
Compared to cell therapy, where cells are injected into a defect region, the treatment of heart infarction with cells seeded in a vascularized scaffold bears advantages, such as an immediate nutrient supply or a controllable and persistent localization of cells. For this purpose, decellularized native tissues are a preferable choice as they provide an in vivo-like microenvironment. However, the quality of such scaffolds strongly depends on the decellularization process. Therefore, two protocols based on sodium dodecyl sulfate or sodium deoxycholate were tailored and optimized for the decellularization of a porcine heart. The obtained scaffolds were tested for their applicability to generate vascularized cardiac patches. Decellularization with sodium dodecyl sulfate was found to be more suitable and resulted in scaffolds with a low amount of DNA, a highly preserved extracellular matrix composition, and structure shown by GAG quantification and immunohistochemistry. After seeding human endothelial cells into the vasculature, a coagulation assay demonstrated the functionality of the endothelial cells to minimize the clotting of blood. Human-induced pluripotent-stem-cell-derived cardiomyocytes in co-culture with fibroblasts and mesenchymal stem cells transferred the scaffold into a vascularized cardiac patch spontaneously contracting with a frequency of 25.61 ± 5.99 beats/min for over 16 weeks. The customized decellularization protocol based on sodium dodecyl sulfate renders a step towards a preclinical evaluation of the scaffolds.
Olea europaea L. Cv. Arbequina (OEA) (Oleaceae) is an olive variety species that has received little attention. Besides our previous work for the chemical profiling of OEA leaves using LC–HRESIMS, an additional 23 compounds are identified. An excision wound model is used to measure wound healing action. Wounds are provided with OEA (2% w/v) or MEBO\(^®\) cream (marketed treatment). The wound closure rate related to vehicle-treated wounds is significantly increased by OEA. Comparing to vehicle wound tissues, significant levels of TGF-β in OEA and MEBO\(^®\) (p < 0.05) are displayed by gene expression patterns, with the most significant levels in OEA-treated wounds. Proinflammatory TNF-α and IL-1β levels are substantially reduced in OEA-treated wounds. The capability of several lignan-related compounds to interact with MMP-1 is revealed by extensive in silico investigation of the major OEA compounds (i.e., inverse docking, molecular dynamics simulation, and ΔG calculation), and their role in the wound-healing process is also characterized. The potential of OEA as a potent MMP-1 inhibitor is shown in subsequent in vitro testing (IC\(_{50}\) = 88.0 ± 0.1 nM). In conclusion, OEA is introduced as an interesting therapeutic candidate that can effectively manage wound healing because of its anti-inflammatory and antioxidant properties.
Candida auris was first described as a yeast pathogen in 2009. Since then, the species has emerged worldwide. In contrast to most other Candida spp., C. auris frequently exhibits multi-drug resistance and is readily transmitted in hospital settings. While most detections so far are from colonised patients, C. auris does cause superficial and life-threatening invasive infections. During management of the first documented C. auris transmission in a German hospital, experts from the National Reference Centers for Invasive Fungal Infections (NRZMyk) and the National Reference Center for Surveillance of Nosocomial Infections screened available literature and integrated available knowledge on infection prevention and C. auris epidemiology and biology to enable optimal containment. Relevant recommendations developed during this process are summarised in this guidance document, intended to assist in management of C. auris transmission and potential outbreak situations. Rapid and effective measures to contain C. auris spread require a multi-disciplinary approach that includes clinical specialists of the affected unit, nursing staff, hospital hygiene, diagnostic microbiology, cleaning staff, hospital management and experts in diagnostic mycology / fungal infections. Action should be initiated in a step-wise process and relevant interventions differ between management of singular C. auris colonised / infected patients and detection of potential C. auris transmission or nosocomial outbreaks.
Prediction of tinnitus perception based on daily life mHealth data using country origin and season
(2022)
Tinnitus is an auditory phantom perception without external sound stimuli. This chronic perception can severely affect quality of life. Because tinnitus symptoms are highly heterogeneous, multimodal data analyses are increasingly used to gain new insights. MHealth data sources, with their particular focus on country- and season-specific differences, can provide a promising avenue for new insights. Therefore, we examined data from the TrackYourTinnitus (TYT) mHealth platform to create symptom profiles of TYT users. We used gradient boosting engines to classify momentary tinnitus and regress tinnitus loudness, using country of origin and season as features. At the daily assessment level, tinnitus loudness can be regressed with a mean absolute error rate of 7.9% points. In turn, momentary tinnitus can be classified with an F1 score of 93.79%. Both results indicate differences in the tinnitus of TYT users with respect to season and country of origin. The significance of the features was evaluated using statistical and explainable machine learning methods. It was further shown that tinnitus varies with temperature in certain countries. The results presented show that season and country of origin appear to be valuable features when combined with longitudinal mHealth data at the level of daily assessment.
Central European forests experience a substantial loss of open-forest organisms due to forest management and increasing nitrogen deposition. However, management strategies, removing different levels of nitrogen, have been rarely evaluated simultaneously.
We tested the additive effects of coppicing and topsoil removal on communities of dung-inhabiting beetles compared to closed forests. We sampled 57 021 beetles, using baited pitfall traps exposed on 27 plots.
Experimental treatments resulted in significantly different communities by promoting open-habitat species. While alpha diversity did not differ among treatments, gamma diversity of Geotrupidae and Scarabaeidae and beta diversity of Staphylinidae were higher in coppice than in forest. Functional diversity of rove beetles was higher in both, coppice and topsoil-removed plots, compared to control plots. This was likely driven by higher habitat heterogeneity in established forest openings. Five dung beetle species and four rove beetle species benefitted from coppicing, one red-listed dung beetle and two rove beetle species benefitted from topsoil removal.
Our results demonstrate that dung-inhabiting beetles related to open forest patches can be promoted by both, coppicing and additional topsoil removal. A mosaic of coppice and bare-soil-rich patches can hence promote landscape-level gamma diversity of dung and rove beetles within forests.
Animal models are important tools to investigate the pathogenesis and develop treatment strategies for breast cancer in humans. In this study, we developed a new three-dimensional in vivo arteriovenous loop model of human breast cancer with the aid of biodegradable materials, including fibrin, alginate, and polycaprolactone. We examined the in vivo effects of various matrices on the growth of breast cancer cells by imaging and immunohistochemistry evaluation. Our findings clearly demonstrate that vascularized breast cancer microtissues could be engineered and recapitulate the in vivo situation and tumor-stromal interaction within an isolated environment in an in vivo organism. Alginate–fibrin hybrid matrices were considered as a highly powerful material for breast tumor engineering based on its stability and biocompatibility. We propose that the novel tumor model may not only serve as an invaluable platform for analyzing and understanding the molecular mechanisms and pattern of oncologic diseases, but also be tailored for individual therapy via transplantation of breast cancer patient-derived tumors.
Background
Pancreatic adenocarcinoma (PDAC) patients with preoperative carbohydrate antigen 19-9 (CA19-9) serum levels higher than 500 U/ml are classified as biologically borderline resectable (BR-B). To date, the impact of cholestasis on preoperative CA19-9 serum levels in these patients has remained unquantified.
Methods
Data on 3079 oncologic pancreatic resections due to PDAC that were prospectively acquired by the German Study, Documentation and Quality (StuDoQ) registry were analyzed in relation to preoperative CA19-9 and bilirubin serum values. Preoperative CA19-9 values were adjusted according to the results of a multivariable linear regression analysis of pathologic parameters, bilirubin, and CA19-9 values.
Results
Of 1703 PDAC patients with tumor located in the pancreatic head, 420 (24.5 %) presented with a preoperative CA19-9 level higher than 500 U/ml. Although receiver operating characteristics (ROC) analysis failed to determine exact CA19-9 cut-off values for prognostic indicators (R and N status), the T, N, and G status; the UICC stage; and the number of simultaneous vein resections increased with the level of preoperative CA19-9, independently of concurrent cholestasis. After adjustment of preoperative CA19-9 values, 18.5 % of patients initially staged as BR-B showed CA19-9 values below 500 U/ml. However, the postoperative pathologic results for these patients did not change compared with the patients who had CA19-9 levels higher than 500 U/ml after bilirubin adjustment.
Conclusions
In this multicenter dataset of PDAC patients, elevation of preoperative CA19-9 correlated with well-defined prognostic pathologic parameters. Bilirubin adjustment of CA19-9 is feasible but does not affect the prognostic value of CA19-9 in jaundiced patients.
The Niger Delta belongs to the largest swamp and mangrove forests in the world hosting many endemic and endangered species. Therefore, its conservation should be of highest priority. However, the Niger Delta is confronted with overexploitation, deforestation and pollution to a large extent. In particular, oil spills threaten the biodiversity, ecosystem services, and local people. Remote sensing can support the detection of spills and their potential impact when accessibility on site is difficult. We tested different vegetation indices to assess the impact of oil spills on the land cover as well as to detect accumulations (hotspots) of oil spills. We further identified which species, land cover types, and protected areas could be threatened in the Niger Delta due to oil spills. The results showed that the Enhanced Vegetation Index, the Normalized Difference Vegetation Index, and the Soil Adjusted Vegetation Index were more sensitive to the effects of oil spills on different vegetation cover than other tested vegetation indices. Forest cover was the most affected land-cover type and oil spills also occurred in protected areas. Threatened species are inhabiting the Niger Delta Swamp Forest and the Central African Mangroves that were mainly affected by oil spills and, therefore, strong conservation measures are needed even though security issues hamper the monitoring and control.
We give a collection of 16 examples which show that compositions \(g\) \(\circ\) \(f\) of well-behaved functions \(f\) and \(g\) can be badly behaved. Remarkably, in 10 of the 16 examples it suffices to take as outer function \(g\) simply a power-type or characteristic function. Such a collection of examples may serve as a source of exercises for a calculus course.
Diabetes Mellitus Is a Possible Risk Factor for Nodo-paranodopathy With Antiparanodal Autoantibodies
(2022)
Background and Objectives
Nodo-paranodopathies are peripheral neuropathies with dysfunction of the node of Ranvier. Affected patients who are seropositive for antibodies against adhesion molecules like contactin-1 and neurofascin show distinct clinical features and a disruption of the paranodal complex. An axoglial dysjunction is also a characteristic finding of diabetic neuropathy. Here, we aim to investigate a possible association of antibody-mediated nodo-paranodopathy and diabetes mellitus (DM).
Methods
We retrospectively analyzed clinical data of 227 patients with chronic inflammatory demyelinating polyradiculoneuropathy and Guillain-Barré syndrome from multiple centers in Germany who had undergone diagnostic testing for antiparanodal antibodies targeting neurofascin-155, pan-neurofascin, contactin-1–associated protein 1, and contactin-1. To study possible direct pathogenic effects of antiparanodal antibodies, we performed immunofluorescence binding assays on human pancreatic tissue sections.
Results The frequency of DM was 33.3% in seropositive patients and thus higher compared with seronegative patients (14.1%, OR = 3.04, 95% CI = 1.31–6.80). The relative risk of DM in seropositive patients was 3.4-fold higher compared with the general German population. Seropositive patients with DM most frequently harbored anti–contactin-1 antibodies and had higher antibody titers than seropositive patients without DM. The diagnosis of DM preceded the onset of neuropathy in seropositive patients. No immunoreactivity of antiparanodal antibodies against pancreatic tissue was detected.
Discussion
We report an association of nodo-paranodopathy and DM. Our results suggest that DM may be a potential risk factor for predisposing to developing nodo-paranodopathy and argue against DM being induced by the autoantibodies. Our findings set the basis for further research investigating underlying immunopathogenetic connections.
Nationwide and consistent information on agricultural land use forms an important basis for sustainable land management maintaining food security, (agro)biodiversity, and soil fertility, especially as German agriculture has shown high vulnerability to climate change. Sentinel-1 and Sentinel-2 satellite data of the Copernicus program offer time series with temporal, spatial, radiometric, and spectral characteristics that have great potential for mapping and monitoring agricultural crops. This paper presents an approach which synergistically uses these multispectral and Synthetic Aperture Radar (SAR) time series for the classification of 17 crop classes at 10 m spatial resolution for Germany in the year 2018. Input data for the Random Forest (RF) classification are monthly statistics of Sentinel-1 and Sentinel-2 time series. This approach reduces the amount of input data and pre-processing steps while retaining phenological information, which is crucial for crop type discrimination. For training and validation, Land Parcel Identification System (LPIS) data were available covering 15 of the 16 German Federal States. An overall map accuracy of 75.5% was achieved, with class-specific F1-scores above 80% for winter wheat, maize, sugar beet, and rapeseed. By combining optical and SAR data, overall accuracies could be increased by 6% and 9%, respectively, compared to single sensor approaches. While no increase in overall accuracy could be achieved by stratifying the classification in natural landscape regions, the class-wise accuracies for all but the cereal classes could be improved, on average, by 7%. In comparison to census data, the crop areas could be approximated well with, on average, only 1% of deviation in class-specific acreages. Using this streamlined approach, similar accuracies for the most widespread crop types as well as for smaller permanent crop classes were reached as in other Germany-wide crop type studies, indicating its potential for repeated nationwide crop type mapping.
There is no approved drug for fibromyalgia syndrome (FMS) in Europe. In the German S3 guideline, amitriptyline, duloxetine, and pregabalin are recommended for temporary use. The aim of this study was to cross-sectionally investigate the current practice of medication in FMS patients in Germany. We systematically interviewed 156 patients with FMS, while they were participating in a larger study. The patients had been stratified into subgroups with and without a decrease in intraepidermal nerve fiber density. The drugs most commonly used to treat FMS pain were nonsteroidal anti-inflammatory drugs (NSAIDs) (41.0% of all patients), metamizole (22.4%), and amitriptyline (12.8%). The most frequent analgesic treatment regimen was “on demand” (53.9%), during pain attacks, while 35.1% of the drugs were administered daily and the remaining in other regimens. Median pain relief as self-rated by the patients on a numerical rating scale (0–10) was 2 points for NSAIDS, 2 for metamizole, and 1 for amitriptyline. Drugs that were discontinued due to lack of efficacy rather than side effects were acetaminophen, flupirtine, and selective serotonin reuptake inhibitors. Reduction in pain severity was best achieved by NSAIDs and metamizole. Our hypothesis that a decrease in intraepidermal nerve fiber density might represent a neuropathic subtype of FMS, which would be associated with better effectiveness of drugs targeting neuropathic pain, could not be confirmed in this cohort. Many FMS patients take “on-demand” medication that is not in line with current guidelines. More randomized clinical trials are needed to assess drug effects in FMS subgroups.
CNS imaging characteristics in fibromyalgia patients with and without peripheral nerve involvement
(2022)
We tested the hypothesis that reduced skin innervation in fibromyalgia syndrome is associated with specific CNS changes. This prospective case–control study included 43 women diagnosed with fibromyalgia syndrome and 40 healthy controls. We further compared the fibromyalgia subgroups with reduced (n = 21) and normal (n = 22) skin innervation. Brains were analysed for cortical volume, for white matter integrity, and for functional connectivity. Compared to controls, cortical thickness was decreased in regions of the frontal, temporal and parietal cortex in the fibromyalgia group as a whole, and decreased in the bilateral pericalcarine cortices in the fibromyalgia subgroup with reduced skin innervation. Diffusion tensor imaging revealed a significant increase in fractional anisotropy in the corona radiata, the corpus callosum, cingulum and fornix in patients with fibromyalgia compared to healthy controls and decreased FA in parts of the internal capsule and thalamic radiation in the subgroup with reduced skin innervation. Using resting-state fMRI, the fibromyalgia group as a whole showed functional hypoconnectivity between the right midfrontal gyrus and the posterior cerebellum and the right crus cerebellum, respectively. The subgroup with reduced skin innervation showed hyperconnectivity between the inferior frontal gyrus, the angular gyrus and the posterior parietal gyrus. Our results suggest that the subgroup of fibromyalgia patients with pronounced pathology in the peripheral nervous system shows alterations in morphology, structural and functional connectivity also at the level of the encephalon. We propose considering these subgroups when conducting clinical trials.
Background:
Methylphenidate (MPH) is the first-line pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD). MPH binds to the dopamine (DA) transporter (DAT), which has high density in the striatum. Assessments of the striatal dopamine transporter by single positron emission computed tomography (SPECT) in childhood and adolescent patients are rare but can provide insight on how the effects of MPH affect DAT availability. The aim of our within-subject study was to investigate the effect of MPH on DAT availability and how responsivity to MPH in DAT availability is linked to clinical symptoms and cognitive functioning.
Methods
Thirteen adolescent male patients (9–16 years) with a diagnosis of ADHD according to the DSM-IV and long-term stimulant medication (for at least 6 months) with MPH were assessed twice within 7 days using SPECT after application of I-123-β-CIT to examine DAT binding potential (DAT BP). SPECT measures took place in an on- and off-MPH status balanced for order across participants. A virtual reality continuous performance test was performed at each time point. Further clinical symptoms were assessed for baseline off-MPH.
Results
On-MPH status was associated with a highly significant change (−29.9%) of striatal DAT BP as compared to off-MPH (t = −4.12, p = 0.002). A more pronounced change in striatal DAT BP was associated with higher off-MPH attentional and externalizing symptom ratings (Pearson r = 0.68, p = 0.01). Striatal DAT BP off-MPH, but not on-MPH, was associated with higher symptom ratings (Pearson r = 0.56, p = 0.04).
Conclusion
Our findings corroborate previous reports from mainly adult samples that MPH changes striatal DAT BP availability and suggest higher off-MPH DAT BP, likely reflecting low baseline DA levels, as a marker of symptom severity.
Background
Children with different underlying malignant diseases require long-term central venous access. As for port systems in a pectoral position, peripherally implanted port systems in the forearm revealed high levels of technical and clinical success in adult cohorts.
Objective
To investigate the technical and clinical outcomes of percutaneous central venous port implantation in the forearm in adolescents.
Materials and methods
Between April 2010 and August 2020, 32 children ages 9 to 17 years with underlying malignancy received 35 totally implantable venous access ports (TIVAPs) in the forearm. All venous port systems were peripherally inserted under ultrasound guidance. Correct catheter placement was controlled by fluoroscopy. As primary endpoints, the technical success, rate of complications and catheter maintenance were analyzed. Secondary endpoints were the side of implantation, vein of catheter access, laboratory results on the day of the procedure, procedural radiation exposure, amount of contrast agent and reasons for port device removal.
Results
Percutaneous TIVAP placement under sonographic guidance was technically successful in 34 of 35 procedures (97.1%). Procedure-related complications did not occur. During the follow-up, 13,684 catheter days were analyzed, revealing 11 complications (0.8 per 1,000 catheter-duration days), Of these 11 complications, 7 were major and 10 occurred late. In seven cases, the port device had to be removed; removal-related complications did not occur.
Conclusion
Peripheral TIVAP placement in the forearms of children is a feasible, effective and safe technique with good midterm outcome. As results are comparable with standard access routes, this technique may be offered as an alternative when intermittent venous access is required.
Purpose
To evaluate the technical and clinical outcome of Sinus-XL stent placement in patients with malignant obstruction syndrome of the inferior vena cava.
Methods
Between October 2010 and January 2021, 21 patients with different malignant primary disease causing inferior vena cava obstruction were treated with Sinus-XL stent implantation. Procedural data, technical and clinical outcome parameters were retrospectively analyzed.
Results
Technical success was 100%. Analysis of available manometry data revealed a significant reduction of the mean translesional pressure gradient following the procedure (p = 0.008). Reintervention rate was 4.8% (1/21). The available follow-up imaging studies showed primary and primary-assisted stent patency rates of 93% (13/14) and 100% (14/14), respectively. Major complications did not occur. The clinical success regarding lower extremity edema was 82.4% (14/17) for the first and 85.7% (18/21) for the last follow-up. Longer lengths of IVC obstruction were associated with reduced clinical improvement after the procedure (p = 0.025). Improvement of intraprocedural manometry results and lower extremity edema revealed only minor correlation. Ascites and anasarca were not significantly positively affected by the procedure.
Conclusion
Sinus-XL stent placement in patients with malignant inferior vena cava obstruction showed high technical success and low complication rates. Regarding the clinical outcome, significant symptom improvement could be achieved in lower extremity edema, whereas ascites and anasarca lacked satisfying symptom relief. Based on our results, this procedure should be considered as a suitable therapy in a palliative care setting for patients with advanced malignant disease.
Background
To analyze the benefit of color-coded summation images in the assessment of target lumen perfusion in patients with aortic dissection and malperfusion syndrome before and after fluoroscopy-guided aortic fenestration.
Methods
Between December 2011 and April 2020 25 patients with Stanford type A (n = 13) or type B dissection (n = 12) and malperfusion syndromes were treated with fluoroscopy-guided fenestration of the dissection flap using a re-entry catheter. The procedure was technically successful in 100% of the cases and included additional iliofemoral stent implantation in four patients. Intraprocedural systolic blood pressure measurements for gradient evaluation were performed in 19 cases. Post-processed color-coded DSA images were obtained from all DSA series before and following fenestration. Differences in time to peak (dTTP) values in the compromised aortic lumen and transluminal systolic blood pressure gradients were analyzed retrospectively. Correlation analysis between dTTP and changes in blood pressure gradients was performed.
Results
Mean TTP prior to dissection flap fenestration was 6.85 ± 1.35 s. After fenestration, mean TTP decreased significantly to 4.96 ± 0.94 s (p < 0.001). Available systolic blood pressure gradients between the true and the false lumen were reduced by a median of 4.0 mmHg following fenestration (p = 0.031), with significant reductions in Stanford type B dissections (p = 0.013) and minor reductions in type A dissections (p = 0.530). A moderate correlation with no statistical significance was found between dTTP and the difference in systolic blood pressure (r = 0.226; p = 0.351).
Conclusions
Hemodynamic parameters obtained from color-coded DSA confirmed a significant reduction of TTP values in the aortic target lumen in terms of an improved perfusion in the compromised aortic region. Color-coded DSA might thus be a suitable complementary tool in the assessment of complex vascular patterns prevailing in aortic dissections, especially when blood pressure measurements are not conclusive or feasible.
High rates of land conversion due to urbanization are causing fragmented and dispersed spatial patterns in the wildland-urban interface (WUI) worldwide. The occurrence of anthropogenic fires in the WUI represents an important environmental and social issue, threatening not only vegetated areas but also periurban inhabitants, as is the case in many Latin American cities. However, research has not focused on the dynamics of the local climate in the WUI. This study analyzes whether wildfires contribute to the increase in land surface temperature (LST) in the WUI of the metropolitan area of the city of Guanajuato (MACG), a semi-arid Mexican city. We estimated the pre- and post-fire LST for 2018–2021. Spatial clusters of high LST were detected using hot spot analysis and examined using ANOVA and Tukey’s post-hoc statistical tests to assess whether LST is related to the spatial distribution of wildfires during our study period. Our results indicate that the areas where the wildfires occurred, and their surroundings, show higher LST. This has negative implications for the local ecosystem and human population, which lacks adequate infrastructure and services to cope with the effects of rising temperatures. This is the first study assessing the increase in LST caused by wildfires in a WUI zone in Mexico.
Nucleic acid motifs consist of conserved and variable nucleotide regions. For functional action, several motifs are combined to modules. The tool AIModules allows identification of such motifs including combinations of them and conservation in several nucleic acid stretches. AIModules recognizes conserved motifs and combinations of motifs (modules) allowing a number of interesting biological applications such as analysis of promoter and transcription factor binding sites (TFBS), identification of conserved modules shared between several gene families, e.g. promoter regions, but also analysis of shared and conserved other DNA motifs such as enhancers and silencers, in mRNA (motifs or regulatory elements e.g. for polyadenylation) and lncRNAs. The tool AIModules presented here is an integrated solution for motif analysis, offered as a Web service as well as downloadable software. Several nucleotide sequences are queried for TFBSs using predefined matrices from the JASPAR DB or by using one’s own matrices for diverse types of DNA or RNA motif discovery. Furthermore, AIModules can find TFBSs common to two or more sequences. Demanding high or low conservation, AIModules outperforms other solutions in speed and finds more modules (specific combinations of TFBS) than alternative available software. The application also searches RNA motifs such as polyadenylation site or RNA–protein binding motifs as well as DNA motifs such as enhancers as well as user-specified motif combinations (https://bioinfo-wuerz.de/aimodules/; alternative entry pages: https://aimodules.heinzelab.de or https://www.biozentrum.uni-wuerzburg.de/bioinfo/computing/aimodules). The application is free and open source whether used online, on-site, or locally.
A modular synthesis of both difurooxa‐ and difuroazadiborepins from a common precursor is demonstrated. Starting from 2,2′‐bifuran, after protection of the positions 5 and 5’ with bulky silyl groups, formation of the novel polycycles proceeds through opening of the furan rings to a dialkyne and subsequent re‐cyclization in the borylation step. The resulting bifuran‐fused diborepins show pronounced stability, highly planar tricyclic structures, and intense blue light emission. Deprotection and transformation into dibrominated building blocks that can be incorporated into π‐extended materials can be performed in one step. Detailed DFT calculations provide information about the aromaticity of the constituent rings of this polycycle.
Background
Regulatory CD4\(^+\)CD25\(^+\)FoxP3\(^+\) T cells (Treg) are a subgroup of T lymphocytes involved in maintaining immune balance. Disturbance of Treg number and impaired suppressive function of Treg correlate with Parkinson’s disease severity. Superagonistic anti-CD28 monoclonal antibodies (CD28SA) activate Treg and cause their expansion to create an anti-inflammatory environment.
Methods
Using the AAV1/2-A53T-α-synuclein Parkinson’s disease mouse model that overexpresses the pathogenic human A53T-α-synuclein (hαSyn) variant in dopaminergic neurons of the substantia nigra, we assessed the neuroprotective and disease-modifying efficacy of a single intraperitoneal dose of CD28SA given at an early disease stage.
Results
CD28SA led to Treg expansion 3 days after delivery in hαSyn Parkinson’s disease mice. At this timepoint, an early pro-inflammation was observed in vehicle-treated hαSyn Parkinson’s disease mice with elevated percentages of CD8\(^+\)CD69\(^+\) T cells in brain and increased levels of interleukin-2 (IL-2) in the cervical lymph nodes and spleen. These immune responses were suppressed in CD28SA-treated hαSyn Parkinson’s disease mice. Early treatment with CD28SA attenuated dopaminergic neurodegeneration in the SN of hαSyn Parkinson’s disease mice accompanied with reduced brain numbers of activated CD4\(^+\), CD8\(^+\) T cells and CD11b\(^+\) microglia observed at the late disease-stage 10 weeks after AAV injection. In contrast, a later treatment 4 weeks after AAV delivery failed to reduce dopaminergic neurodegeneration.
Conclusions
Our data indicate that immune modulation by Treg expansion at a timepoint of overt inflammation is effective for treatment of hαSyn Parkinson’s disease mice and suggest that the concept of early immune therapy could pose a disease-modifying option for Parkinson’s disease patients.
Quantifying tree defoliation by insects over large areas is a major challenge in forest management, but it is essential in ecosystem assessments of disturbance and resistance against herbivory. However, the trajectory from leaf-flush to insect defoliation to refoliation in broadleaf trees is highly variable. Its tracking requires high temporal- and spatial-resolution data, particularly in fragmented forests.
In a unique replicated field experiment manipulating gypsy moth Lymantria dispar densities in mixed-oak forests, we examined the utility of publicly accessible satellite-borne radar (Sentinel-1) to track the fine-scale temporal trajectory of defoliation. The ratio of backscatter intensity between two polarizations from radar data of the growing season constituted a canopy development index (CDI) and a normalized CDI (NCDI), which were validated by optical (Sentinel-2) and terrestrial laser scanning (TLS) data as well by intensive caterpillar sampling from canopy fogging.
The CDI and NCDI strongly correlated with optical and TLS data (Spearman's ρ = 0.79 and 0.84, respectively). The ΔNCDII\(_{Defoliation(A−C)}\) significantly explained caterpillar abundance (R\(^{2}\) = 0.52). The NCDI at critical timesteps and ΔNCDI related to defoliation and refoliation well discriminated between heavily and lightly defoliated forests.
We demonstrate that the high spatial and temporal resolution and the cloud independence of Sentinel-1 radar potentially enable spatially unrestricted measurements of the highly dynamic canopy herbivory. This can help monitor insect pests, improve the prediction of outbreaks and facilitate the monitoring of forest disturbance, one of the high priority Essential Biodiversity Variables, in the near future.
Usher syndrome, the most prevalent cause of combined hereditary vision and hearing impairment, is clinically and genetically heterogeneous. Moreover, several conditions with phenotypes overlapping Usher syndrome have been described. This makes the molecular diagnosis of hereditary deaf-blindness challenging. Here, we performed exome sequencing and analysis on 7 Mexican and 52 Iranian probands with combined retinal degeneration and hearing impairment (without intellectual disability). Clinical assessment involved ophthalmological examination and hearing loss questionnaire. Usher syndrome, most frequently due to biallelic variants in MYO7A (USH1B in 16 probands), USH2A (17 probands), and ADGRV1 (USH2C in 7 probands), was diagnosed in 44 of 59 (75%) unrelated probands. Almost half of the identified variants were novel. Nine of 59 (15%) probands displayed other genetic entities with dual sensory impairment, including Alström syndrome (3 patients), cone-rod dystrophy and hearing loss 1 (2 probands), and Heimler syndrome (1 patient). Unexpected findings included one proband each with Scheie syndrome, coenzyme Q10 deficiency, and pseudoxanthoma elasticum. In four probands, including three Usher cases, dual sensory impairment was either modified/aggravated or caused by variants in distinct genes associated with retinal degeneration and/or hearing loss. The overall diagnostic yield of whole exome analysis in our deaf-blind cohort was 92%. Two (3%) probands were partially solved and only 3 (5%) remained without any molecular diagnosis. In many cases, the molecular diagnosis is important to guide genetic counseling, to support prognostic outcomes and decisions with currently available and evolving treatment modalities.
G-protein-coupled receptors (GPCRs) are hypothesized to possess molecular mobility over a wide temporal range. Until now the temporal range has not been fully accessible due to the crucially limited temporal range of available methods. This in turn, may lead relevant dynamic constants to remain masked. Here, we expand this dynamic range by combining fluorescent techniques using a spot confocal setup. We decipher mobility constants of β\(_{2}\)-adrenergic receptor over a wide time range (nanosecond to second). Particularly, a translational mobility (10 µm\(^{2}\)/s), one order of magnitude faster than membrane associated lateral mobility that explains membrane protein turnover and suggests a wider picture of the GPCR availability on the plasma membrane. And a so far elusive rotational mobility (1-200 µs) which depicts a previously overlooked dynamic component that, despite all complexity, behaves largely as predicted by the Saffman-Delbrück model.
Defects in DNA repair pathways have been associated with an improved response to immune checkpoint inhibition (ICI). In particular, patients with the nucleotide excision repair (NER) defect disease Xeroderma pigmentosum (XP) responded impressively well to ICI treatment. Recently, in melanoma patients, pretherapeutic XP gene expression was predictive for anti-programmed cell death-1 (PD-1) ICI response. The underlying mechanisms of this finding are still to be revealed. Therefore, we used CRISPR/Cas9 to disrupt XPA in A375 melanoma cells. The resulting subclonal cell lines were investigated by Sanger sequencing. Based on their genetic sequence, candidates from XPA exon 1 and 2 were selected and further analyzed by immunoblotting, immunofluorescence, HCR and MTT assays. In XPA exon 1, we established a homozygous (c.19delG; p.A7Lfs*8) and a compound heterozygous (c.19delG/c.19_20insG; p.A7Lfs*8/p.A7Gfs*55) cell line. In XPA exon 2, we generated a compound heterozygous mutated cell line (c.206_208delTTG/c.208_209delGA; p.I69_D70delinsN/p.D70Hfs*31). The better performance of the homozygous than the heterozygous mutated exon 1 cells in DNA damage repair (HCR) and post-UV-C cell survival (MTT), was associated with the expression of a novel XPA protein variant. The results of our study serve as the fundamental basis for the investigation of the immunological consequences of XPA disruption in melanoma.
Hematopoietic stem and progenitor cell (HSPC) maintenance and the differentiation of various lineages is a highly complex but precisely regulated process. Multiple signaling pathways and an array of transcription factors influence HSPC maintenance and the differentiation of individual lineages to constitute a functional hematopoietic system. Nuclear factor of activated T cell (NFAT) family transcription factors have been studied in the context of development and function of multiple mature hematopoietic lineage cells. However, until now their contribution in HSPC physiology and HSPC differentiation to multiple hematopoietic lineages has remained poorly understood. Here, we show that NFAT proteins, specifically NFATc1, play an indispensable role in the maintenance of HSPCs. In the absence of NFATc1, very few HSPCs develop in the bone marrow, which are functionally defective. In addition to HSPC maintenance, NFATc1 also critically regulates differentiation of lymphoid, myeloid, and erythroid lineage cells from HSPCs. Deficiency of NFATc1 strongly impaired, while enhanced NFATc1 activity augmented, the differentiation of these lineages, which further attested to the vital involvement of NFATc1 in regulating hematopoiesis. Hematopoietic defects due to lack of NFATc1 activity can lead to severe pathologies such as lymphopenia, myelopenia, and a drastically reduced lifespan underlining the critical role NFATc1 plays in HSPC maintenance and in the differentaion of various lineages. Our findings suggest that NFATc1 is a critical component of the myriad signaling and transcriptional regulators that are essential to maintain normal hematopoiesis.
The transcription factors of the nuclear factor of activated T cell (NFAT) family play a crucial role in multiple aspects of T cell function. It has recently been reported that NFATs play an important role in the suppressive function of CD4\(^+\)CD25\(^+\)Foxp3\(^+\) regulatory T (T\(_{reg}\)) cells. In this study, we have investigated the role of NFATs in the thymic development of T\(_{reg}\) cells in mice. We show that NFAT factors are dispensable for the development of Foxp3\(^+\) T\(_{reg}\) cells in the thymus but are critical for the maintenance of both the phenotype and survival of T\(_{reg}\) cells in the thymus as well as in peripheral lymphoid organs. Specifically, the homeostasis of CD4\(^+\)CD25\(^+\)Foxp3\(^+\) but not the CD4\(^+\)CD25\(^-\)Foxp3\(^+\) fraction is severely perturbed when NFAT signaling is blocked, leading to a strongly reduced T\(_{reg}\) population. We underscored this intriguing effect of NFAT on CD4\(^+\)CD25\(^+\)Foxp3\(^+\) T\(_{reg}\) cells to the disruption of survival signals provided by interleukin 2 (IL-2). Accordingly, blocking T\(_{reg}\) cell death by abolishing the activity of pro-apoptotic Bcl-2 family member Bim, compensated for the survival defects induced due to a lack of NFAT-IL-2-IL-2R signaling. Inhibition of NFAT activity led to a strong reduction in the number of Foxp3\(^+\) T\(_{reg}\) cells; however, it did not influence the level of Foxp3 expression on an individual cell basis. In addition, we show a differential effect of IL-2 and IL-7 signaling on Foxp3\(^+\) T\(_{reg}\) versus CD4\(^+\)CD25\(^-\) T cell development, again underlining the dispensability of NFAT signaling in the development, but not in the maintenance of Foxp3\(^+\) T\(_{reg}\) cells.
Photo‐initiated intramolecular charge transfer (ICT) processes play a pivotal role in the excited state reaction dynamics in donor‐bridge‐acceptor systems. The efficacy of such a process can be improved by modifying the extent of π‐conjugation, relative orientation/twists of the donor/acceptor entities and polarity of the environment. Herein, 4‐dimethylamino‐4′‐cyanodiphenylacetylene (DACN‐DPA), a typical donor‐π‐bridge‐acceptor system, was chosen to unravel the role of various internal coordinates that govern the extent of photo‐initiated ICT dynamics. Transient absorption (TA) spectra of DACN‐DPA in n‐hexane exhibit a lifetime of >2 ns indicating the formation of a triplet state while, in acetonitrile, a short time‐constant of ∼2 ps indicates the formation of charge transferred species. Ultrafast Raman loss spectroscopy (URLS) measurements show distinct temporal and spectral dynamics of Raman bands associated with C≡C and C=C stretching vibrations. The appearance of a new band at ∼1492 cm\(^{−1}\) in acetonitrile clearly indicates structural modification during the ultrafast ICT process. Furthermore, these observations are supported by TD‐DFT computations.
The Indigenous tribe called the Wiwa lives retracted in the Sierra Nevada de Santa Marta, Colombia. Little is known about their health status and whether the health care system in place covers their needs. In 2017 and 2018, a permanent physician was in charge for the Wiwa. Diseases and complaints were registered, ranked, and classified with the ICD-10 coding. Datasets from the Indigenous health care provider Dusakawi, collected from local health points and health brigades travelling sporadically into the fields for short visits, were compared. Furthermore, a list of provided medication was evaluated regarding the recorded needs. The most common complaints found were respiratory, infectious and parasitic, and digestive diseases. The top ten diagnoses collected in the health points and in the health brigade datasets were similar, although with a different ranking. The available medication showed a basic coverage only, with a critical lack of treatment for many severe, chronic, and life-threatening diseases. Most of the detected diseases in the Indigenous population are avoidable by an improvement in health care access, an expansion of the provided medication, and an increase in knowledge, hygiene, and life standards.
Objectives
To assess the impact of HIIT performed at school, i.e. both in connection with physical education (intra-PE) and extracurricular sports activities (extra-PE), on the physical fitness and health of children and adolescents.
Methods
PubMed and SPORTDiscus were searched systematically utilizing the following criteria for inclusion: (1) healthy children and adolescents (5–18 years old) of normal weight; (2) HIIT performed intra- and/or extra-PE for at least 5 days at an intensity ≥ 80% of maximal heart rate (HR\(_{max}\)) or peak oxygen uptake (VO\(_{2peak}\)) or as Functional HIIT; (3) comparison with a control (HIIT versus alternative interventions); and (4) pre- and post-analysis of parameters related to physical fitness and health. The outcomes with HIIT and the control interventions were compared utilizing Hedges’ g effect size (ES) and associated 95% confidence intervals.
Results
Eleven studies involving 707 participants who performed intra-PE and 388 participants extra-PE HIIT were included. In comparison with the control interventions, intra-PE HIIT improved mean ES for neuromuscular and anaerobic performance (ES jump performance: 5.89 ± 5.67 (range 1.88–9.90); ES number of push-ups: 6.22 (range n.a.); ES number of sit-ups: 2.66 ± 2.02 (range 1.24–4.09)), as well as ES fasting glucose levels (− 2.68 (range n.a.)) more effectively, with large effect sizes. Extra-PE HIIT improved mean ES for neuromuscular and anaerobic performance (ES jump performance: 1.81 (range n.a.); ES number of sit-ups: 2.60 (range n.a.)) to an even greater extent, again with large effect sizes. Neither form of HIIT was more beneficial for parameters related to cardiorespiratory fitness than the control interventions.
Conclusion
Compared to other forms of exercise (e.g. low-to-moderate-intensity running or walking), both intra- and extra-PE HIIT result in greater improvements in neuromuscular and anaerobic performance, as well as in fasting levels of glucose in school children.
Stalk cell polar ion transport provide for bladder‐based salinity tolerance in Chenopodium quinoa
(2022)
Chenopodium quinoa uses epidermal bladder cells (EBCs) to sequester excess salt. Each EBC complex consists of a leaf epidermal cell, a stalk cell, and the bladder.
Under salt stress, sodium (Na\(^{+}\)), chloride (Cl\(^{−}\)), potassium (K\(^{+}\)) and various metabolites are shuttled from the leaf lamina to the bladders. Stalk cells operate as both a selectivity filter and a flux controller.
In line with the nature of a transfer cell, advanced transmission electron tomography, electrophysiology, and fluorescent tracer flux studies revealed the stalk cell’s polar organization and bladder‐directed solute flow.
RNA sequencing and cluster analysis revealed the gene expression profiles of the stalk cells. Among the stalk cell enriched genes, ion channels and carriers as well as sugar transporters were most pronounced. Based on their electrophysiological fingerprint and thermodynamic considerations, a model for stalk cell transcellular transport was derived.
Regular physical activity during childhood and adolescence is associated with health benefits. Consequently, numerous health promotion programs for children and adolescents emphasize the enhancement of physical activity. However, the ActivityStat hypothesis states that increases in physical activity in one domain are compensated for by decreasing physical activity in another domain. Currently, little is known about how physical activity varies in children and adolescents within intervals of one day or multiple days. This systematic review provides an overview of studies that analyzed changes in (overall) physical activity, which were assessed with objective measurements, or compensatory mechanisms caused by increases or decreases in physical activity in a specific domain in children and adolescents. A systematic search of electronic databases (PubMed, Scopus, Web of Science, SportDiscus) was performed with a priori defined inclusion criteria. Two independent researchers screened the literature and identified and rated the methodological quality of the studies. A total of 77 peer-reviewed articles were included that analyzed changes in overall physical activity with multiple methodological approaches resulting in compensation or displacement. Of 40,829 participants, 16,265 indicated compensation associated with physical activity. Subgroup analyses separated by study design, participants, measurement instrument, physical activity context, and intervention duration also showed mixed results toward an indication of compensation. Quality assessment of the included studies revealed that they were of high quality (mean = 0.866). This review provides inconclusive results about compensation in relation to physical activity. A trend toward increased compensation in interventional studies and in interventions of longer duration have been observed.
The neuropeptide pigment-dispersing factor (PDF) plays a prominent role in the circadian clock of many insects including honey bees. In the honey bee brain, PDF is expressed in about 15 clock neurons per hemisphere that lie between the central brain and the optic lobes. As in other insects, the bee PDF neurons form wide arborizations in the brain, but certain differences are evident. For example, they arborize only sparsely in the accessory medulla (AME), which serves as important communication center of the circadian clock in cockroaches and flies. Furthermore, all bee PDF neurons cluster together, which makes it impossible to distinguish individual projections. Here, we investigated the developing bee PDF network and found that the first three PDF neurons arise in the third larval instar and form a dense network of varicose fibers at the base of the developing medulla that strongly resembles the AME of hemimetabolous insects. In addition, they send faint fibers toward the lateral superior protocerebrum. In last larval instar, PDF cells with larger somata appear and send fibers toward the distal medulla and the medial protocerebrum. In the dorsal part of the medulla serpentine layer, a small PDF knot evolves from which PDF fibers extend ventrally. This knot disappears during metamorphosis and the varicose arborizations in the putative AME become fainter. Instead, a new strongly stained PDF fiber hub appears in front of the lobula. Simultaneously, the number of PDF neurons increases and the PDF neuronal network in the brain gets continuously more complex.
Echolocation behavior, a navigation strategy based on acoustic signals, allows scientists to explore neural processing of behaviorally relevant stimuli. For the purpose of orientation, bats broadcast echolocation calls and extract spatial information from the echoes. Because bats control call emission and thus the availability of spatial information, the behavioral relevance of these signals is undiscussable. While most neurophysiological studies, conducted in the past, used synthesized acoustic stimuli that mimic portions of the echolocation signals, recent progress has been made to understand how naturalistic echolocation signals are encoded in the bat brain. Here, we review how does stimulus history affect neural processing, how spatial information from multiple objects and how echolocation signals embedded in a naturalistic, noisy environment are processed in the bat brain. We end our review by discussing the huge potential that state-of-the-art recording techniques provide to gain a more complete picture on the neuroethology of echolocation behavior.
Mycobacterium tuberculosis (Mtb) inhibits host oxidative stress responses facilitating its survival in macrophages; however, the underlying molecular mechanisms are poorly understood. Here, we identified a Mtb acetyltransferase (Rv3034c) as a novel counter actor of macrophage oxidative stress responses by inducing peroxisome formation. An inducible Rv3034c deletion mutant of Mtb failed to induce peroxisome biogenesis, expression of the peroxisomal β-oxidation pathway intermediates (ACOX1, ACAA1, MFP2) in macrophages, resulting in reduced intracellular survival compared to the parental strain. This reduced virulence phenotype was rescued by repletion of Rv3034c. Peroxisome induction depended on the interaction between Rv3034c and the macrophage mannose receptor (MR). Interaction between Rv3034c and MR induced expression of the peroxisomal biogenesis proteins PEX5p, PEX13p, PEX14p, PEX11β, PEX19p, the peroxisomal membrane lipid transporter ABCD3, and catalase. Expression of PEX14p and ABCD3 was also enhanced in lungs from Mtb aerosol-infected mice. This is the first report that peroxisome-mediated control of ROS balance is essential for innate immune responses to Mtb but can be counteracted by the mycobacterial acetyltransferase Rv3034c. Thus, peroxisomes represent interesting targets for host-directed therapeutics to tuberculosis.
In ischemic stroke (IS) impairment of the blood-brain barrier (BBB) has an important role in the secondary deterioration of neurological function. BBB disruption is associated with ischemia-induced inflammation, brain edema formation, and hemorrhagic infarct transformation, but the underlying mechanisms are incompletely understood. Dysfunction of endothelial cells (EC) may play a central role in this process. Although neuronal NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome upregulation is an established trigger of inflammation in IS, the contribution of its expression in EC is unclear. We here used brain EC, exposed them to oxygen and glucose deprivation (OGD) in vitro, and analyzed their survival depending on inflammasome inhibition with the NLRP3-specific drug MCC950. During OGD, EC death could significantly be reduced when targeting NLRP3, concomitant with diminished endothelial NLRP3 expression. Furthermore, MCC950 led to reduced levels of Caspase 1 (p20) and activated Gasdermin D as markers for pyroptosis. Moreover, inflammasome inhibition reduced the secretion of pro-inflammatory chemokines, cytokines, and matrix metalloproteinase-9 (MMP9) in EC. In a translational approach, IS was induced in C57Bl/6 mice by 60 mins transient middle cerebral artery occlusion and 23 hours of reperfusion. Stroke volume, functional outcome, the BBB integrity, and-in good agreement with the in vitro results-MMP9 secretion as well as EC survival improved significantly in MCC950-treated mice. In conclusion, our results establish the NLRP3 inflammasome as a critical pathogenic effector of stroke-induced BBB disruption by activating inflammatory signaling cascades and pyroptosis in brain EC.
Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a mainstay of acute ischemic stroke treatment but is associated with bleeding complications, especially after prolonged large vessel occlusion. Recently, inhibition of the NLRP3 inflammasome led to preserved blood–brain barrier (BBB) integrity in experimental stroke in vivo. To further address the potential of NLRP3 inflammasome inhibition as adjunct stroke treatment we used immortalized brain derived endothelial cells (bEnd5) as an in vitro model of the BBB. We treated bEnd5 with rt-PA in combination with the NLRP3 specific inhibitor MCC950 or vehicle under normoxic as well as ischemic (OGD) conditions. We found that rt-PA exerted a cytotoxic effect on bEnd5 cells under OGD confirming that rt-PA is harmful to the BBB. This detrimental effect could be significantly reduced by MCC950 treatment. Moreover, under ischemic conditions, the Cell Index — a sensible indicator for a patent BBB — and the protein expression of Zonula occludens 1 stabilized after MCC950 treatment. At the same time, the extent of endothelial cell death and NLRP3 expression decreased. In conclusion, NLRP3 inhibition can protect the BBB from rt-PA-induced damage and thereby potentially increase the narrow time window for safe thrombolysis in stroke.
Chemotherapy, the standard treatment for pancreatic ductal adenocarcinoma (PDAC), has only a modest effect on the outcome of patients with late-stage disease. Investigations of the genetic features of PDAC have demonstrated a frequent occurrence of mutations in genes involved in homologous recombination (HR), especially in the breast cancer susceptibility gene 2 (BRCA2). Olaparib, a poly(ADP-ribose) polymerase (PARP) inhibitor, is approved as a maintenance treatment for patients with advanced PDAC with germline BRCA1/2 mutations following a platinum-containing first-line regimen. Limitations to the use of PARP inhibitors are represented by the relatively small proportion of patients with mutations in BRCA1/2 genes and the modest capability of these substances of inducing objective response. We have previously shown that pancreatic cancer with BRCA2 mutations exhibits a remarkably enhanced sensitivity towards tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) receptor-stimulating agents. We thus aimed to investigate the effect of combined treatment with PARP inhibitors and TRAIL receptor-stimulating agents in pancreatic cancer and its dependency on the BRCA2 gene status. The respective effects of TRAIL-targeting agents and the PARP inhibitor olaparib or of their combination were assessed in pancreatic cancer cell lines and patient-derived organoids. In addition, BRCA2-knockout and -complementation models were investigated. The effects of these agents on apoptosis, DNA damage, cell cycle, and receptor surface expression were assessed by immunofluorescence, Western blot, and flow cytometry. PARP inhibition and TRAIL synergized to cause cell death in pancreatic cancer cell lines and PDAC organoids. This effect proved independent of BRCA2 gene status in three independent models. Olaparib and TRAIL in combination caused a detectable increase in DNA damage and a concentration-dependent cell cycle arrest in the G2/M and S cell cycle phases. Olaparib also significantly increased the proportion of membrane-bound death receptor 5. Our results provide a preclinical rationale for the combination of PARP inhibitors and TRAIL receptor agonists for the treatment of pancreatic cancer and suggest that the use of PARP inhibitors could be extended to patients without BRCA2 mutations if used in combination with TRAIL agonists.
The rapid development of green and sustainable materials opens up new possibilities in the field of applied research. Such materials include nanocellulose composites that can integrate many components into composites and provide a good chassis for smart devices. In our study, we evaluate four approaches for turning a nanocellulose composite into an information storage or processing device: 1) nanocellulose can be a suitable carrier material and protect information stored in DNA. 2) Nucleotide-processing enzymes (polymerase and exonuclease) can be controlled by light after fusing them with light-gating domains; nucleotide substrate specificity can be changed by mutation or pH change (read-in and read-out of the information). 3) Semiconductors and electronic capabilities can be achieved: we show that nanocellulose is rendered electronic by iodine treatment replacing silicon including microstructures. Nanocellulose semiconductor properties are measured, and the resulting potential including single-electron transistors (SET) and their properties are modeled. Electric current can also be transported by DNA through G-quadruplex DNA molecules; these as well as classical silicon semiconductors can easily be integrated into the nanocellulose composite. 4) To elaborate upon miniaturization and integration for a smart nanocellulose chip device, we demonstrate pH-sensitive dyes in nanocellulose, nanopore creation, and kinase micropatterning on bacterial membranes as well as digital PCR micro-wells. Future application potential includes nano-3D printing and fast molecular processors (e.g., SETs) integrated with DNA storage and conventional electronics. This would also lead to environment-friendly nanocellulose chips for information processing as well as smart nanocellulose composites for biomedical applications and nano-factories.
Osmotic stress can be detrimental to plants, whose survival relies heavily on proteomic plasticity. Protein ubiquitination is a central post-translational modification in osmotic-mediated stress. In this study, we used the K-Ɛ-GG antibody enrichment method integrated with high-resolution mass spectrometry to compile a list of 719 ubiquitinated lysine (K-Ub) residues from 450 Arabidopsis root membrane proteins (58% of which are transmembrane proteins), thereby adding to the database of ubiquitinated substrates in plants. Although no ubiquitin (Ub) motifs could be identified, the presence of acidic residues close to K-Ub was revealed. Our ubiquitinome analysis pointed to a broad role of ubiquitination in the internalization and sorting of cargo proteins. Moreover, the simultaneous proteome and ubiquitinome quantification showed that ubiquitination is mostly not involved in membrane protein degradation in response to short osmotic treatment but that it is putatively involved in protein internalization, as described for the aquaporin PIP2;1. Our in silico analysis of ubiquitinated proteins shows that two E2 Ub-conjugating enzymes, UBC32 and UBC34, putatively target membrane proteins under osmotic stress. Finally, we revealed a positive role for UBC32 and UBC34 in primary root growth under osmotic stress.
In general, humans preferentially look at conspecifics in naturalistic images. However, such group-based effects might conceal systematic individual differences concerning the preference for social information. Here, we investigated to what degree fixations on social features occur consistently within observers and whether this preference generalizes to other measures of social prioritization in the laboratory as well as the real world. Participants carried out a free viewing task, a relevance taps task that required them to actively select image regions that are crucial for understanding a given scene, and they were asked to freely take photographs outside the laboratory that were later classified regarding their social content. We observed stable individual differences in the fixation and active selection of human heads and faces that were correlated across tasks and partly predicted the social content of self-taken photographs. Such relationship was not observed for human bodies indicating that different social elements need to be dissociated. These findings suggest that idiosyncrasies in the visual exploration and interpretation of social features exist and predict real-world behavior. Future studies should further characterize these preferences and elucidate how they shape perception and interpretation of social contexts in healthy participants and patients with mental disorders that affect social functioning.
Background
Research in the field of surgery is mainly driven by aiming for trauma reduction as well as for personalized treatment concepts. Beyond laparoscopy, other proposed approaches for further reduction of the therapeutic trauma have failed to achieve clinical translation, with few notable exceptions. We believe that this is mainly due to a lack of flexibility and high associated costs. We aimed at addressing these issues by developing a novel minimally invasive operating platform and a preoperative design workflow for patient-individual adaptation and cost-effective rapid manufacturing of surgical manipulators. In this article, we report on the first in-vitro cholecystectomy performed with our operating platform.
Methods
The single-port overtube (SPOT) is a snake-like surgical manipulator for minimally invasive interventions. The system layout is highly flexible and can be adapted in design and dimensions for different kinds of surgery, based on patient- and disease-specific parameters. For collecting and analyzing this data, we developed a graphical user interface, which assists clinicians during the preoperative planning phase. Other major components of our operating platform include an instrument management system and a non-sterile user interface. For the trial surgery, we used a validated phantom which was further equipped with a porcine liver including the gallbladder.
Results
Following our envisioned preoperative design workflow, a suitable geometry of the surgical manipulator was determined for our trial surgery and rapidly manufactured by means of 3D printing. With this setup, we successfully performed a first in-vitro cholecystectomy, which was completed in 78 min.
Conclusions
By conducting the trial surgery, we demonstrated the effectiveness of our PLAFOKON operating platform. While some aspects – especially regarding usability and ergonomics – can be further optimized, the overall performance of the system is highly promising, with sufficient flexibility and strength for conducting the necessary tissue manipulations.
In early 2022, the Coronavirus disease 2019 (COVID-19) remains a global challenge. COVID-19 is caused by an increasing number of variants of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we report an outbreak of SARS-CoV-2 breakthrough infections related to a student festive event with 100 mostly vaccinated guests, which took place in Northern Bavaria, Germany, in October 2021. The data were obtained by retrospective guest interviews. In total, 95 students participated in the study, with 94 being fully vaccinated and 24 reporting infection by the delta variant. Correlation analyses among 15 examined variables revealed that time spent at the event, conversation with the supposed index person, and a homologous viral vector vaccination regime were significant risk factors for infection. Non-significant observations related to higher rates of infection included time since last vaccination, shared use of drinking vessels, and number of individual person-to-person contacts at the event. Our data suggest that a high rate of breakthrough infections with the delta variant occurs if no preventive measures are practiced. To limit infection risk, high-quality testing of participants should be considered a mandatory measure at gatherings, irrespective of the participants' vaccination status.
In this study, we aimed to understand how restaurants can contribute to climate change mitigation via menu design. We investigated two types of interventions: changing the configuration of menu entries with variable side dishes so that the most climate-friendly option is set as the default and indicating the greenhouse gas emission of each dish via carbon labels. In an online simulation experiment, 265 participants were shown the menus of nine different restaurants and had to choose exactly one dish per menu. In six menus, the main dishes were presented with different default options: the side dish was associated either with the highest or with the lowest greenhouse gas emissions. The other three menus consisted of unitary dishes for which the default rules did not apply. All menus were presented either with or without carbon labels for each dish option. The results indicated that more climate-friendly dish choices resulting in lower greenhouse gas emissions were made with the low-emission than the high-emission default condition, and when carbon labels were present rather than absent. The effects of both interventions interacted, which indicates that the interventions partly overlap with regard to cognitive predecessors of choice behavior, such as attentional focus and social norms. The results suggest that the design of restaurant menus has a considerable effect on the carbon footprint of dining.
We analyze a variety of integration schemes for the momentum space functional renormalization group calculation with the goal of finding an optimized scheme. Using the square lattice t-t' Hubbard model as a testbed we define and benchmark the quality. Most notably we define an error estimate of the solution for the ordinary differential equation circumventing the issues introduced by the divergences at the end of the FRG flow. Using this measure to control for accuracy we find a threefold reduction in number of required integration steps achievable by choice of integrator. We herewith publish a set of recommended choices for the functional renormalization group, shown to decrease the computational cost for FRG calculations and representing a valuable basis for further investigations.