Refine
Year of publication
Document Type
- Journal article (801) (remove)
Language
- German (801) (remove)
Keywords
- Organische Chemie (63)
- Anorganische Chemie (53)
- Chemie (49)
- Kind (22)
- Erziehung (16)
- Psychologie (12)
- Alter Orient (11)
- Fremdsprachenlernen (10)
- Fremdsprachenunterricht (10)
- Aufsatzsammlung (9)
Institute
- Institut für Anorganische Chemie (130)
- Institut für Organische Chemie (79)
- Institut für Psychologie (bis Sept. 2007) (76)
- Neuphilologisches Institut - Moderne Fremdsprachen (55)
- Theodor-Boveri-Institut für Biowissenschaften (52)
- Institut für deutsche Philologie (34)
- Institut für Psychologie (33)
- Institut für Altertumswissenschaften (bis Sept. 2007) (28)
- Institut für Anatomie und Zellbiologie (28)
- Universitätsbibliothek (27)
Sonstige beteiligte Institutionen
No abstract available.
Zum eblaitischen Gott Kura
(1992)
No Abstract available
No abstract available
No abstract available
No abstract available
No abstract available
No abstract available.
no Abstract available
kulbābu
(1991)
No abstract available
Hethiter und Hurriter
(1991)
No Abstract available
No abstract available.
No abstract available.
No abstract available.
no Abstract available
No abstract available
No abstract available
No abstract available.
Hurritische Lexikographie
(1985)
No abstract available.
Hurritisch nari(ya) "fünf"
(1984)
no Abstract available
Ein neues Lamaštu-Amulett
(1979)
No abstract available.
Zu den Wollmaßen in Nuzi
(1988)
No abstract available.
No abstract available.
"Verhafte ihn!"
(1990)
No abstract available.
No abstract available
Zum hurritischen Lexikon I
(1972)
No abstract available
Zum hurritischen Ergativ
(1969)
No abstract available
Zum hurritischen Lexikon II
(1974)
No abstract available
No abstract available
No Abstract available
Cutaneous leishmaniasis is initiated by the bite of an infected sandfly and inoculation of Leishmania major parasites into the mammalian skin. Macrophages are known to playa central role in the course of infection because they are the prime host cells and funetion as antigen-presenting eells (APC) for induetion of the eell-mediated immune response. However, in addition to maerophages in the dermis. the skin eontains epidermal Langerhans eells (LC) which ean present antigen (Ag) to T cells. Therefore, using a murine model of cutaneous leishmaniasis, we analyzed the ability of epidermal cells to induce a T eell response to L.major. The results demonstrated that freshly isolated LC, but not cuItured LC, are highly active in presenting L.major Ag in vitro to T cells from primed mice and to a L.major-specific T cell clone. Furthermore, freshly isolated LC had the ability to retain L.major Ag in immunogenic form for at least 2 days. Their efficiency was much greater than that of irradiated spleen cells, a standard population of APC. LC stimulated both T cell proliferation and production of the Iymphokines interleukin (IL)-2 and IL-4. The response was Ag specific and could be induced by lysate of L. major parasites and by live organisms. The data suggest that epidermal LC are important APC in eutaneous leishmaniasis. They may perform a critical funetion by eapturing L.major Ag in the skin and presenting it either to quiescent T eells circulating through the draining lymph node or locally to T effector cells infiltrating the cutaneous lesion.