Refine
Year of publication
Document Type
- Journal article (8314) (remove)
Language
Keywords
- Organische Chemie (122)
- Anorganische Chemie (119)
- Toxikologie (112)
- Medizin (98)
- inflammation (85)
- Biochemie (81)
- Chemie (68)
- cancer (62)
- gene expression (62)
- Psychologie (61)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (1374)
- Institut für Anorganische Chemie (383)
- Institut für Psychologie (382)
- Physikalisches Institut (362)
- Neurologische Klinik und Poliklinik (341)
- Medizinische Klinik und Poliklinik II (333)
- Medizinische Klinik und Poliklinik I (330)
- Institut für Organische Chemie (310)
- Institut für Molekulare Infektionsbiologie (297)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (251)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (229)
- Institut für Pharmakologie und Toxikologie (224)
- Institut für Virologie und Immunbiologie (224)
- Institut für Geographie und Geologie (205)
- Klinik und Poliklinik für Anästhesiologie (ab 2004) (195)
- Pathologisches Institut (194)
- Klinik und Poliklinik für Nuklearmedizin (177)
- Rudolf-Virchow-Zentrum (177)
- Institut für Anatomie und Zellbiologie (167)
- Julius-von-Sachs-Institut für Biowissenschaften (157)
- Kinderklinik und Poliklinik (155)
- Lehrstuhl für Orthopädie (155)
- Institut für Klinische Epidemiologie und Biometrie (152)
- Institut für Informatik (147)
- Neurochirurgische Klinik und Poliklinik (146)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (128)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (128)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (127)
- Institut für Humangenetik (120)
- Institut für Hygiene und Mikrobiologie (120)
- Institut für Pharmazie und Lebensmittelchemie (109)
- Institut für Psychologie (bis Sept. 2007) (106)
- Institut für Theoretische Physik und Astrophysik (106)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (106)
- Institut für Klinische Neurobiologie (104)
- Klinik und Poliklinik für Strahlentherapie (90)
- Neuphilologisches Institut - Moderne Fremdsprachen (90)
- Comprehensive Cancer Center Mainfranken (89)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (85)
- Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II) (84)
- Institut für Mathematik (74)
- Frauenklinik und Poliklinik (73)
- Klinik und Poliklinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie (72)
- Institut für Physikalische und Theoretische Chemie (70)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (68)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (66)
- Fakultät für Physik und Astronomie (63)
- Institut für Experimentelle Biomedizin (60)
- Institut für Sportwissenschaft (59)
- Lehrstuhl für Biochemie (55)
- Medizinische Fakultät (51)
- Institut Mensch - Computer - Medien (50)
- Physiologisches Institut (48)
- Urologische Klinik und Poliklinik (47)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (46)
- Augenklinik und Poliklinik (43)
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (40)
- Center for Computational and Theoretical Biology (39)
- Institut für deutsche Philologie (39)
- Institut für Altertumswissenschaften (bis Sept. 2007) (32)
- Institut für Funktionsmaterialien und Biofabrikation (32)
- Institut für Klinische Biochemie und Pathobiochemie (30)
- Lehrstuhl für Molekulare Psychiatrie (29)
- Institut für Altertumswissenschaften (28)
- Klinik und Poliklinik für Thorax-, Herz- u. Thorakale Gefäßchirurgie (27)
- Universitätsbibliothek (27)
- Institut für Medizinische Strahlenkunde und Zellforschung (25)
- Neuphilologisches Institut - Moderne Fremdsprachen (bis 2007) (24)
- Institut für Pädagogik (bis Sept. 2007) (21)
- Institut für Allgemeinmedizin (19)
- Zentrum für Sprachen (19)
- Betriebswirtschaftliches Institut (17)
- Institut für Geographie (17)
- Institut für Politikwissenschaft und Soziologie (17)
- Poliklinik für Zahnärztliche Prothetik (17)
- Institut für Psychotherapie und Medizinische Psychologie (16)
- Institut für Rechtsmedizin (16)
- Institut für Orientalische Philologie (15)
- Institut für Pädagogik (14)
- Abteilung für Parodontologie (in der Poliklinik für Zahnerhaltung und Parodontologie) (12)
- Institut für Gesellschafts-, Steuer- und Arbeitsrecht (12)
- Institut für Mineralogie und Kristallstrukturlehre (11)
- Poliklinik für Zahnerhaltung und Parodontologie (11)
- Institut für Klinische Transfusionsmedizin und Hämotherapie (10)
- Institut für Medizinische Lehre und Ausbildungsforschung (10)
- Institut für Philosophie (9)
- Institut für Sonderpädagogik (9)
- Universität Würzburg (9)
- Graduate School of Life Sciences (8)
- Institut für Systemimmunologie (8)
- Missionsärztliche Klinik (8)
- Poliklinik für Kieferorthopädie (7)
- Volkswirtschaftliches Institut (7)
- Institut für Politische Wissenschaft (6)
- Institut für Sonderpädagogik (bis Sept. 2007) (6)
- Institut für Internationales Recht, Europarecht und Europäisches Privatrecht (5)
- Institut für Kulturwissenschaften Ost- und Südasiens (5)
- Institut für Slavistik (5)
- Katholisch-Theologische Fakultät (5)
- Sportzentrum (5)
- Fakultät für Chemie und Pharmazie (4)
- Institut für Archäologie (4)
- Institut für Geschichte (4)
- Institut für klassische Philologie (4)
- Juristische Fakultät (4)
- Klinik für Anaesthesiologie (bis 2003) (4)
- Graduate School of the Humanities (3)
- Fachgruppe Didaktik der Biologie (2)
- Fakultät für Biologie (2)
- Fakultät für Mathematik und Informatik (2)
- Institut für Biblische Theologie (2)
- Institut für Evangelische Theologie und Religionspädagogik (2)
- Institut für Praktische Theologie (2)
- Institut für Strafrecht und Kriminologie (2)
- Institut für medizinische Datenwissenschaften (2)
- Institut für romanische Philologie (2)
- Martin-von-Wagner-Museum (2)
- Abteilung für Forensische Psychiatrie (1)
- Botanischer Garten (1)
- Fakultät für Humanwissenschaften (Philos., Psycho., Erziehungs- u. Gesell.-Wissensch.) (1)
- Institut für Bürgerliches Recht und Zivilprozessrecht (1)
- Institut für Geschichte der Medizin (1)
- Institut für Kulturwissenschaften Ost- und Südasiens (bis Sept. 2007) (1)
- Institut für Kunstgeschichte (1)
- Institut für Soziologie (1)
- Institut für Staats- und Verwaltungsrecht, Rechtsphilosophie (1)
- Institut für Systematische Theologie (1)
- Klinik und Polikliniken für Zahn-, Mund- und Kieferkrankheiten (1)
- Krankenhaus für Psychiatrie, Psychotherapie und Neurologie des Bezirks Unterfranken (1)
- Lehrstuhl für Silicatchemie (1)
- Philosophische Fakultät (Histor., philolog., Kultur- und geograph. Wissensch.) (1)
- Rechenzentrum (1)
- Wirtschaftswissenschaftliche Fakultät (1)
- Zentrale Einrichtungen (1)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (11)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (7)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (5)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (5)
- Bernhard-Heine-Centrum für Bewegungsforschung (4)
- Johns Hopkins University School of Medicine (4)
- Zentraleinheit Klinische Massenspektrometrie (4)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (2)
- Interdisciplinary Center for Clinical Research (2)
- Interdisziplinäres Zentrum für Klinische Forschung (IZKF) (2)
- Klinische Studienzentrale (Universitätsklinikum) (2)
- Krankenhaushygiene und Antimicrobial Stewardship (2)
- Krankenhaushygiene und Antimicrobial Stewardship (Universitätsklinikum) (2)
- Krankenhaushygiene und Antimicrobial Stewardship, Universitätsklinikum Würzburg (2)
- Lehrstuhl für Regeneration Muskuloskelettaler Gewebe (2)
- Mildred Scheel Early Career Center (2)
- Mildred-Scheel-Nachwuchszentrum (2)
- Naturalis Biodiversity Centre (2)
- Röntgen Center for Complex Material Systems (RCCM), Am Hubland, 97074 W¨urzburg, Germany (2)
- Würzburg-Dresden Cluster of Excellence ct.qmat (2)
- Zentrallabor, Universitätsklinikum Würzburg (2)
- Ökologische Station Fabrikschleichach (2)
- Agricultural Center, BASF SE, 67117 Limburgerhof, Germany (1)
- Apotheke, Universitätsklinikum Würzburg (1)
- Arizona State University, Tempe, Arizona, USA (1)
- Bavarian Center for Applied Energy Research (ZAE Bayern), 97074 Würzburg, Germany (1)
- Bavarian Center for Applied Energy Research e.V. (ZAE Bayern) (1)
- Blindeninstitut, Ohmstr. 7, 97076, Wuerzburg, Germany (1)
- Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich, Germany (1)
- Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, Göttingen (1)
- Comprehensive Cancer Center Mainfranken, University Hospital Würzburg, Würzburg, Germany (1)
- Comprehensive Hearing Center, Department of ORL, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, Würzburg, Germany (1)
- Core Unit Systemmedizin (1)
- DFG (1)
- DNA Analytics Core Facility, Biocenter, University of Wuerzburg, Wuerzburg, Germany (1)
- DNA Analytics Core Facility, Biocenter, University of Würzburg, Würzburg, Germany (1)
- Datenintegrationszentrum Würzburg (DIZ) (1)
- Deakin University, Australia (1)
- Department of Animal Ecology and Tropical Biology, University of Würzburg, Würzburg, Germany (1)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (1)
- Department of Cellular Biochemistry, University Medical Center Göttingen (1)
- Department of Cellular Biochemistry, University Medical Centre Göttingen (1)
- Department of Chemistry, Sungkyunkwan University, 440-746 Suwon, Republic of Korea (1)
- Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany (1)
- Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden (1)
- Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090 Vienna, Austria (1)
- Department of Medicine A, University Hospital of Münster, Münster, Germany (1)
- Department of Molecular Biology, University Medical Centre Göttingen (1)
- Department of Nuclear Medicine, Kanazawa University (1)
- Department of Nuclear Medicine, Philipps University Marburg, Marburg, Germany (1)
- Department of Paediatric Radiology, Institute of Diagnostic and Interventional Radiology, Josef-Schneider-Straße 2, Wuerzburg 97080, Germany (1)
- Department of Pediatrics, Pediatrics I, Innsbruck Medical University, Anichstr. 35, 6020, Innsbruck, Austria (1)
- Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria (1)
- Deutsches Zentrum für Präventionsforschung Psychische Gesundheit (DZPP) (1)
- Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Osaka University Graduate School of Medicine, Suita Japan (1)
- EMBL, Structural and Computational Biology Unit, Heidelberg, Germany (1)
- Fachbereich Physik, Universität Konstanz, D-78464 Konstanz, Germany (1)
- Forschungsstation Fabrikschleichach (1)
- Fraunhofer Institute Interfacial Engineering and Biotechnology (IGB) (1)
- Fraunhofer-Institute for Applied Optics and Precision Engineering IOF Jena, Germany (1)
- Friedrich Schiller University Jena, Germany (1)
- Genelux Corporation, San Diego Science Center, 3030 Bunker Hill Street, Suite 310, San Diego, California 92109, USA (1)
- Georg August University School of Science (1)
- Göttingen Center for Molecular Biosciences, University of Göttingen (1)
- Helmholtz Institute for RNA-based Infection Biology (HIRI), Josef-Schneider-Straße 2/D15, DE-9708 Wuerzburg, Germany (1)
- Helmholtz Institute for RNA-based Infection Biology (HIRI), Josef-Schneider-Straße 2/D15, DE-97080 Wuerzburg, Germany (1)
- IZKF (Interdisziplinäres Zentrum für Klinische Forschung), Universität Würzburg (1)
- IZKF Laboratory for Microarray Applications, University Hospital of Wuerzburg, Wuerzburg, Germany (1)
- Institut for Molecular Biology and CMBI, Department of Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria (1)
- Institut für Molekulare Infektionsbiologie (MIB) der Universität Würzburg (1)
- Institut für Optik und Atomare Physik, Technische Universität Berlin, 10623 Berlin, Germany (1)
- Institute of Cancer Research (ICR) London (1)
- Institute of Organic Chemistry and Center for Molecular Biosciences Innsbruck, CMBI, Leopold-Franzens University Innsbruck, Austria (1)
- Interdisciplinary Bank of Biological Material and Data Würzburg (IBDW) (1)
- Interdisciplinary Center for Clinical Research (IZKF), Würzburg, Germany (1)
- Interdisziplinäre Biomaterial- und Datenbank Würzburg (ibdw) (1)
- Interdisziplinäres Amyloidosezentrum Nordbayern (1)
- Interdisziplinäres Zentrum für Klinische Forschung (ZIKF), Würzburg (1)
- International Society for Nutritional Psychiatric Research (1)
- Johns Hopkins Medicine (1)
- Johns Hopkins School of Medicine, Baltimore, MD, USA (1)
- Johns Hopkins School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA (1)
- Johns Hopkins University, Baltimore, MD, U.S. (1)
- Johns Hopkis School of Medicine (1)
- Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan (1)
- Lehrstuhl für Röntgenmikroskopie (1)
- MRB Forschungszentrum für Magnet-Resonanz-Bayern e.V., Am Hubland, D-97074 Würzburg (1)
- Max Planck Institute for Biophysical Chemistry (1)
- Max Planck Institute for Biophysical Chemistry, Am Faßberg 11, DE-37077 Goetingen, Germany (1)
- Max Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen (1)
- Max Planck Institute for Biophysical Chemistry, Research Group Structure and Function of Molecular Machines, Göttingen (1)
- Max Planck School of Photonics Jena, Germany (1)
- Max-Planck Institute for Biophysical Chemistry, Department of Molecular Biology, Göttingen (1)
- Microarray Core Unit, Interdisciplinary Center for Clinical Science, University of Würzburg, Versbacher Straße, Würzburg 97080, Germany (1)
- Molecular Nutrition Research, Interdisciplinary Research Center, Justus-Liebig-University of Giessen (1)
- Muskuloskelettales Centrum Würzburg (MCW) (1)
- National Cardiovascular and Cerebral Center, Suita, Japan (1)
- National Institute for Materials Science, Tsukuba, Japan (1)
- Novartis Pharma AG, Lichtstrasse 35, CH-4056 Basel, Switzerland (1)
- Paul Scherrer Institut (1)
- Professional School of Education (1)
- Research Center for Infectious Diseases (ZINF), University of Wuerzburg, Wuerzburg, Germany, (1)
- Research Center for Infectious Diseases (ZINF), University of Würzburg, Würzburg, Germany (1)
- Research Center for Infectious Diseases, University of Wuerzburg, Wuerzburg 97080, Germany (1)
- Research Center for Magnetic-Resonance-Bavaria (MRB), Wuerzburg, Germany (1)
- Research Center of Infectious Diseases (ZINF) of the University of Wurzburg, Germany (1)
- Röntgen Research Center for Complex Material Systems, Hubland Campus Nord, Emil-Fischer-Straße 42, D-97074 Würzburg, Germany (1)
- Service Centre InterNational Transfer (Universität Würzburg) (1)
- Servicezentrum Medizin-Informatik (1)
- Servicezentrum Medizin-Informatik (Universitätsklinikum) (1)
- Technische Universität Dortmund, Fakultät für Informatik, Computer Graphics Group (1)
- University Medical Center Göttingen, Department of Cellular Biochemistry, Göttingen (1)
- University of Bari Medical School, Bari, Italy (1)
- University of Oldenburg, Germany (1)
- University of Science and Technology of China, Hefei, China (1)
- Universität Erlangen, Institut für Geschichte und Ethik der Medizin (1)
- Universität Kassel, Fachbereich Gesellschaftswissenschaften, Mittelalterliche Geschichte (1)
- Universität Salzburg, Fachbereich Germanistik (1)
- Wilhelm Conrad Röntgen-Center for Complex Material Systems, Würzburg (1)
- Wurzburg Fabry Center for Interdisciplinary Therapy (FAZIT), Wurzburg, Germany (1)
- Würzburg Fabry Center for Interdisciplinary Therapy (FAZIT), University of Würzburg, Würzburg, Germany (1)
- Zentrum für Infektionsforschung, Universität Würzburg (1)
- Zentrum für soziale Implikationen künstlicher Intelligenz (SOCAI) (1)
- Ökologische Station, Fabrikschleichach (1)
ResearcherID
- D-1221-2009 (1)
EU-Project number / Contract (GA) number
- 602805 (25)
- 701983 (24)
- 669054 (17)
- 682586 (15)
- 728018 (15)
- 787937 (12)
- 224631 (10)
- 288566 (10)
- 602133 (10)
- 646737 (10)
- 244090 (7)
- 259867 (6)
- 309962 (6)
- 643051 (6)
- 823881 (6)
- 101007642 (5)
- 241778 (5)
- 336012 (5)
- 223153 (4)
- 223175 (4)
- 226852 (4)
- 250194 (4)
- 311781 (4)
- 311932 (4)
- 336305 (4)
- 607051 (4)
- 617989 (4)
- 677819 (4)
- 766118 (4)
- 813871 (4)
- 825575 (4)
- 848261 (4)
- 01EW1902 (3)
- 223138 (3)
- 247919 (3)
- 261357 (3)
- 287320 (3)
- 289706 (3)
- 339306 (3)
- 602300 (3)
- 614623 (3)
- 633983 (3)
- 667302 (3)
- 678119 (3)
- 686070 (3)
- 733297 (3)
- 759139 (3)
- 824128 (3)
- 018741 (2)
- 201099 (2)
- 227632 (2)
- 245009 (2)
- 250320 (2)
- 262055 (2)
- 265432 (2)
- 268985 (2)
- 277775 (2)
- 281338 (2)
- 304617 (2)
- 305312 (2)
- 308377 (2)
- 312325 (2)
- 315877 (2)
- 316704 (2)
- 318798 (2)
- 327199 (2)
- 335568 (2)
- 340983 (2)
- 503474 (2)
- 618045 (2)
- 636930 (2)
- 654148 (2)
- 669830 (2)
- 680966 (2)
- 693023 (2)
- 721016 (2)
- 721394 (2)
- 722046 (2)
- 754658 (2)
- 758985 (2)
- 761307 (2)
- 764860 (2)
- 765937 (2)
- 847507 (2)
- 897276 (2)
- 946184 (2)
- 953327 (2)
- 956414 (2)
- 011937 (1)
- 018696 (1)
- 026155 (1)
- 031A408B (1)
- 031A409B (1)
- 037220 (1)
- 037602 (1)
- 0800978 (1)
- 101003595 (1)
- 10100764 (1)
- 101015930 (1)
- 101016923 (1)
- 101034412 (1)
- 101041177 (1)
- 101042738 (1)
- 101045956 (1)
- 101052587 (1)
- 101065772 (1)
- 101076402 (1)
- 101079460 (1)
- 115300 (1)
- 115525 (1)
- 18741 (1)
- 19-COP-0031 (1)
- 20-3044-2-11 (1)
- 20100317 (1)
- 20100407 (1)
- 201024 (1)
- 201052 (1)
- 2016 FGR 0053 (1)
- 201962 (1)
- 2020010013 (1)
- 202088 (1)
- 202213 (1)
- 203291 (1)
- 211078 (1)
- 212372 (1)
- 212525 (1)
- 214469 (1)
- 216027 (1)
- 216886 (1)
- 222719 (1)
- 222943 (1)
- 223044 (1)
- 224635 (1)
- 227159 (1)
- 229289 (1)
- 229294 (1)
- 229571 (1)
- 230331-PROPEREMO (1)
- 232944 (1)
- 241447 (1)
- 241592 (1)
- 241719 (1)
- 241909 (1)
- 242175 (1)
- 242175-VascuBone (1)
- 242175‐VascuBone (1)
- 242257 (1)
- 243964 (1)
- 247447 (1)
- 249177 (1)
- 249929 (1)
- 250194-Carnivorom (1)
- 253511 (1)
- 257531 (1)
- 259735 (1)
- 259753 (1)
- 260338 (1)
- 260986 (1)
- 261474 (1)
- 261492 (1)
- 26230120009 (1)
- 262773 (1)
- 266777 (1)
- 267436 (1)
- 268962 (1)
- 270089 (1)
- 270212 (1)
- 274769 (1)
- 27731 (1)
- 278864 (1)
- 278864-2 (1)
- 279062 (1)
- 286213 (1)
- 289442 (1)
- 289600 (1)
- 290605 (1)
- 291377 (1)
- 291840 (1)
- 294683 (1)
- 294823 (1)
- 296679 (1)
- 297557 (1)
- 303674 (1)
- 304961 (1)
- 305653 (1)
- 306387 (1)
- 306447 (1)
- 307701 (1)
- 307955 (1)
- 311575 (1)
- 312147 (1)
- 314911 (1)
- 316633 (1)
- 316790 (1)
- 318987 (1)
- 320377 (1)
- 320570 (1)
- 322865 (1)
- 324612 (1)
- 339728 (1)
- 340602 (1)
- 506675 (1)
- 517836 (1)
- 602102 (1)
- 602531 (1)
- 602812 (1)
- 604391 (1)
- 606950 (1)
- 609,020 (1)
- 610307 (1)
- 613931 (1)
- 615613 (1)
- 616346 (1)
- 617198 (1)
- 617891 (1)
- 633784 (1)
- 634361 (1)
- 634935 (1)
- 638536 (1)
- 638988 (1)
- 639445 (1)
- 640012 (1)
- 641458 (1)
- 641833 (1)
- 643238 (1)
- 644076 (1)
- 645993 (1)
- 647281 (1)
- 647426 (1)
- 649124 (1)
- 654000 (1)
- 658195 (1)
- 660375 (1)
- 667421 (1)
- 667787 (1)
- 668036 (1)
- 668353 (1)
- 668679 (1)
- 677302 (1)
- 679288 (1)
- 681103 (1)
- 686271 (1)
- 692185 (1)
- 694913 (1)
- 695376 (1)
- 696802 (1)
- 715923 (1)
- 716344 (1)
- 720270 (1)
- 722064 (1)
- 723770 (1)
- 725832 (1)
- 739593 (1)
- 741491 (1)
- 755523 (1)
- 759206 (1)
- 772376 (1)
- 776019 (1)
- 777215 (1)
- 810850 (1)
- 818182 (1)
- 818846 (1)
- 819800 (1)
- 834709 (1)
- 835102) (1)
- 836421 (1)
- 840741 (1)
- 848002 (1)
- 853546 (1)
- 853988 (1)
- 862665 (1)
- 871158 (1)
- 874758 (1)
- 874827 (1)
- 955910 (1)
- 955974 (1)
- 956548 (1)
- 965286 (1)
- BWF/H/52228/2012/13.10.10-1/3.4,6 (1)
- CP22/00082 (1)
- CoG 721016–HERPES (1)
- ERC-2013-StG-336305 (1)
- ERC-2016-CoG 721016-HERPES (1)
- ERC-2018-ADG/NCI-CAD (1)
- ERC335568 (1)
- ESF-ZDEX 4.0 (1)
- ESF_14-BM-A55-0005_16 (1)
- EU-1650-0006 (1)
- EU250194 (1)
- FKZ01EW1902 (1)
- FOOD‑CT‑2004‑506378 (1)
- FP7-ICT MINIMAL (1)
- FP7/2007-2013 (1)
- HEALTH-F2-2009-241778 (1)
- HEALTHF2- 2008-201099 (1)
- LIFE12 BIO/AT/000143 (1)
- LIFE20 NAT/AT/000049 (1)
- LaserLab Europe (LLC001917) (1)
- PI21/00314 (1)
- PIEF-GA-2013-623006 (1)
- PITN-GA-2012-316704 (1)
- PTQ2020-011372 (1)
- QLK1-2001-01614 (1)
- RTI2018-093747-B-10 (1)
- ZAM 5-85018031 (1)
This paper is devoted to a theoretical and numerical investigation of Nash equilibria and Nash bargaining problems governed by bilinear (input-affine) differential models. These systems with a bilinear state-control structure arise in many applications in, e.g., biology, economics, physics, where competition between different species, agents, and forces needs to be modelled. For this purpose, the concept of Nash equilibria (NE) appears appropriate, and the building blocks of the resulting differential Nash games are different control functions associated with different players that pursue different non-cooperative objectives. In this framework, existence of Nash equilibria is proved and computed with a semi-smooth Newton scheme combined with a relaxation method. Further, a related Nash bargaining (NB) problem is discussed. This aims at determining an improvement of all players’ objectives with respect to the Nash equilibria. Results of numerical experiments successfully demonstrate the effectiveness of the proposed NE and NB computational framework.
Rag1\(^{−/−}\) mice, lacking functional B and T cells, have been extensively used as an adoptive transfer model to evaluate neuroinflammation in stroke research. However, it remains unknown whether natural killer (NK) cell development and functions are altered in Rag1\(^{−/−}\) mice as well. This connection has been rarely discussed in previous studies but might have important implications for data interpretation. In contrast, the NOD-Rag1\(^{null}\)IL2rg\(^{null}\) (NRG) mouse model is devoid of NK cells and might therefore eliminate this potential shortcoming. Here, we compare immune-cell frequencies as well as phenotype and effector functions of NK cells in Rag1\(^{−/−}\) and wildtype (WT) mice using flow cytometry and functional in vitro assays. Further, we investigate the effect of Rag1\(^{−/−}\) NK cells in the transient middle cerebral artery occlusion (tMCAO) model using antibody-mediated depletion of NK cells and adoptive transfer to NRG mice in vivo. NK cells in Rag1\(^{−/−}\) were comparable in number and function to those in WT mice. Rag1\(^{−/−}\) mice treated with an anti-NK1.1 antibody developed significantly smaller infarctions and improved behavioral scores. Correspondingly, NRG mice supplemented with NK cells were more susceptible to tMCAO, developing infarctions and neurological deficits similar to Rag1−/− controls. Our results indicate that NK cells from Rag1−/− mice are fully functional and should therefore be considered in the interpretation of immune-cell transfer models in experimental stroke. Fortunately, we identified the NRG mice, as a potentially better-suited transfer model to characterize individual cell subset-mediated neuroinflammation in stroke.
Despite successful recanalization of large-vessel occlusions in acute ischemic stroke, individual patients profit to a varying degree. Dynamic susceptibility-weighted perfusion and dynamic T1-weighted contrast-enhanced blood-brain barrier permeability imaging may help to determine secondary stroke injury and predict clinical outcome. We prospectively performed perfusion and permeability imaging in 38 patients within 24 h after successful mechanical thrombectomy of an occlusion of the middle cerebral artery M1 segment. Perfusion alterations were evaluated on cerebral blood flow maps, blood-brain barrier disruption (BBBD) visually and quantitatively on ktrans maps and hemorrhagic transformation on susceptibility-weighted images. Visual BBBD within the DWI lesion corresponded to a median ktrans elevation (IQR) of 0.77 (0.41–1.4) min−1 and was found in all 7 cases of hypoperfusion (100%), in 10 of 16 cases of hyperperfusion (63%), and in only three of 13 cases with unaffected perfusion (23%). BBBD was significantly associated with hemorrhagic transformation (p < 0.001). While BBBD alone was not a predictor of clinical outcome at 3 months (positive predictive value (PPV) = 0.8 [0.56–0.94]), hypoperfusion occurred more often in patients with unfavorable clinical outcome (PPV = 0.43 [0.10–0.82]) compared to hyperperfusion (PPV = 0.93 [0.68–1.0]) or unaffected perfusion (PPV = 1.0 [0.75–1.0]). We show that combined perfusion and permeability imaging reveals distinct infarct signatures after recanalization, indicating the severity of prior ischemic damage. It assists in predicting clinical outcome and may identify patients at risk of stroke progression.
Metastatic pheochromocytoma and paraganglioma: signs and symptoms related to catecholamine secretion
(2021)
Background
The presence or future development of metastatic pheochromocytomas or paragangliomas (mPPGLs) can be difficult to diagnose or predict at initial presentation. Since production of catecholamines from mPPGLs is different from non-metastatic tumors (non-mPPGLs), this study aimed to clarify whether presenting catecholamine-related signs and symptoms (cSS) might also differ.
Methods
The study included 249 patients, 43 with mPPGL and 206 with non-mPPGL. Clinical data at the time of biochemical diagnosis (i.e. at entry into the study) were used to generate a cumulative score of cSS for each patient.
Results
Patients with mPPGL were significantly younger (43.3 ± 14 vs. 48.9 ± 16.1 years) and included a lower proportion of females (39.5% vs. 60.7%) than patients with non-mPPGLs. Frequencies of signs and symptoms did not differ between the two groups. Patients with mPPGLs had lower (P < 0.001) urinary excretion of epinephrine (3.5 (IQR, 1.9—6.5) µg/day) than those with non-mPPGLs (19.1 (IQR, 4.3—70.2) µg/day). There was no difference in urinary excretion of norepinephrine. In patients with mPPGLs a high cSS score was associated with high urinary excretion of norepinephrine and normetanephrine. In contrast, in patients with non-mPPGLs, a high cSS was associated with high urinary excretion of epinephrine and metanephrine.
Conclusion
Although presenting signs and symptoms were associated with production of norepinephrine in patients with mPPGLs and of epinephrine in patients with non-mPPGLs, there were no differences in signs and symptoms between the two groups. Therefore, consideration of signs and symptoms does not appear helpful for distinguishing patients with and without mPPGLs.
Despite the widespread application of landslide susceptibility analyses, there is hardly any information about whether or not the occurrence of recent landslide events was correctly predicted by the relevant susceptibility maps. Hence, the objective of this study is to evaluate four landslide susceptibility maps retrospectively in a landslide-prone area of the Swabian Alb (Germany). The predictive performance of each susceptibility map is evaluated based on a landslide event triggered by heavy rainfalls in the year 2013. The retrospective evaluation revealed significant variations in the predictive accuracy of the analyzed studies. Both completely erroneous as well as very precise predictions were observed. These differences are less attributed to the applied statistical method and more to the quality and comprehensiveness of the used input data. Furthermore, a literature review of 50 peer-reviewed articles showed that most landslide susceptibility analyses achieve very high validation scores. 73% of the analyzed studies achieved an area under curve (AUC) value of at least 80%. These high validation scores, however, do not reflect the high uncertainty in statistical susceptibility analysis. Thus, the quality assessment of landslide susceptibility maps should not only comprise an index-based, quantitative validation, but also an additional qualitative plausibility check considering local geomorphological characteristics and local landslide mechanisms. Finally, the proposed retrospective evaluation approach cannot only help to assess the quality of susceptibility maps and demonstrate the reliability of such statistical methods, but also identify issues that will enable the susceptibility maps to be improved in the future.
Background
Individuals’ physical and mental health, as well as their chances of returning to work after their ability to work is damaged, can be addressed by medical rehabilitation.
Aim
This study investigated the developmental trends of mental and physical health among patients in medical rehabilitation and the roles of self-efficacy and physical fitness in the development of mental and physical health.
Design
A longitudinal design that included four time-point measurements across 15 months.
Setting
A medical rehabilitation center in Germany.
Population
Participants included 201 patients who were recruited from a medical rehabilitation center.
Methods
To objectively measure physical fitness (lung functioning), oxygen reabsorption at anaerobic threshold (VO2AT) was used, along with several self-report scales.
Results
We found a nonlinear change in mental health among medical rehabilitation patients. The results underscored the importance of medical rehabilitation for patients’ mental health over time. In addition, patients’ physical health was stable over time. The initial level of physical fitness (VO2AT) positively predicted their mental health and kept the trend more stable. Self-efficacy appeared to have a positive relationship with mental health after rehabilitation treatment.
Conclusions
This study revealed a nonlinear change in mental health among medical rehabilitation patients. Self-efficacy was positively related to mental health, and the initial level of physical fitness positively predicted the level of mental health after rehabilitation treatment.
Clinical Rehabilitation
More attention could be given to physical capacity and self-efficacy for improving and maintaining rehabilitants’ mental health.
In this study, we examined the conditional indirect and direct relations of pain-related cognitions to depression. Subjective helplessness was included as presumably mediating the relations of catastrophizing and thought suppression to depression due to motivational deficits. In addition, moderating effects of dispositional action versus state orientation were analyzed, whereby state orientation indicates volitional deficits in coping with distress. The study was based on self-report data from 536 patients with chronic non-specific low back pain at the beginning of inpatient rehabilitation. Moderated mediation analyses were performed. The indirect catastrophizing- and thought suppression-depression relations were (partially) mediated by subjective helplessness; and moderated by failure-related action versus state orientation. Moreover, action versus state orientation moderated the direct relation of thought suppression to depression. Results suggest that catastrophizing, thought suppression, and subjective helplessness do not lead to depression unless associated with self-regulatory inability (i.e., state orientation). In contrast, action-oriented patients more effectively self-regulate pain-related emotions, disengage from rumination, and distract from pain and thus better avoid the debilitating effects of negative pain-related cognitions on depression. Future research and treatment may more strongly focus on the role of motivational and volitional deficits underlying learned helplessness and depression in chronic pain.
Purpose
The subclassification of adrenal cancers according to the WHO classification in ordinary, myxoid, oncocytic, and sarcomatoid as well as pediatric types is well established, but the criteria for each subtype are not sufficiently determined and the relative frequency of the different types of adrenal cancers has not been studied in large cohorts. Therefore, our large collection of surgically removed adrenal cancers should be reviewed o establish the criteria for the subtypes and to find out the frequency of the various types.
Methods
In our series of 521 adrenal cancers the scoring systems of Weiss et al., Hough et al., van Slooten et al. and the new Helsinki score system were used for the ordinary type of cancer (97% of our series) and the myxoid type (0.8%). For oncocytic carcinomas (2%), the scoring system of Bisceglia et al. was applied.
Results
Discrepancies between benign and malignant diagnoses from the first thee classical scoring systems are not rare (22% in our series) and could be resolved by the Helsinki score especially by Ki-67 index (more than 8% unequivocally malignant). Since all our cancer cases are positive in the Helsinki score, this system can replace the three elder systems. For identification of sarcomatoid cancer as rarest type in our series (0.2%), the scoring systems are not practical but additional immunostainings used for soft tissue tumors and in special cases molecular pathology are necessary to differentiate these cancers from adrenal sarcomas. According to the relative frequencies of the different subtypes of adrenal cancers the main type is the far most frequent (97%) followed by the oncocytic type (2%), the myxoid type (0.8%) and the very rare sarcomatoid type (0.2%).
Conclusions
The Helsinki score is the best for differentiating adrenal carcinomas of the main, the oncocytic, and the myxoid type in routine work. Additional scoring systems for these carcinomas are generally not any longer necessary. Signs of proliferation (mitoses and Ki-67 index) and necroses are the most important criteria for diagnosis of malignancy.
Context
Primary aldosteronism (PA) is the most frequent form of endocrine hypertension. Besides its deleterious impact on cardiovascular target organ damage, PA is considered to cause osteoporosis.
Patients and methods
We assessed bone turnover in a subset of 36 postmenopausal women with PA. 18 patients had unilateral PA and were treated by adrenalectomy, whereas 18 patients had bilateral PA and received mineralocorticoid receptor antagonist (MRA) therapy respectively. 18 age- and BMI-matched females served as controls. To estimate bone remodeling, we measured the bone turnover markers intact procollagen 1 N-terminal propeptide, bone alkaline phosphatase, osteocalcin and tartrate resistant acid phosphatase 5b in plasma by chemiluminescent immunoassays at time of diagnosis and one year after initiation of treatment.
Study design
Observational longitudinal cohort study.
Setting
Tertiary care hospital.
Results
Compared with controls, patients with PA had mildly elevated osteocalcin at baseline (p = 0.013), while the other bone markers were comparable between both groups. There were no differences between the unilateral and the bilateral PA subgroup. One year after initiation of MRA treatment with spironolactone bone resorption and bone formation markers had significantly decreased in patients with bilateral PA. In contrast, patients adrenalectomized because of unilateral PA showed no significant change of bone turnover markers.
Conclusion
This study shows that aldosterone excess in postmenopausal women with PA is not associated with a relevant increase of bone turnover markers at baseline. However, we observed a significant decrease of bone markers in patients treated with spironolactone, but not in patients treated by adrenalectomy.