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Jura non in singulas personas, sed generaliter constituuntur. Doch es ist zu ergänzen: Urteile sind im Einzelfall zu treffen. Nicht ganz unähnlich wäre auch der wissenschaftlich diagnostizierende Psychologe zu mahnen. Psychologische Diagnostik zielt auf den Einzelfall ab, obwohl die Entscheidungen über ihn auf der Basis von allgemeingültigen Gesetzen der empirisch-psychologischen Wissenschaft herbeizuführen sind (Tack, 1982). Im folgenden wird dazu zuerst der Sonderstatus der Forensischen Diagnostik herausgestellt, wobei zur Untermauerung die besonderen Leitziele der forensisch-psychologischen Diagnostik angeführt werden. Die folgenden Abschnitte widmen sich dann einerseits dem Nutzen der psychometrischen Integration von Kriterien, andererseits geht es um die psychometrische Gewinnung von Befunden über Einzelkriterien, wozu auf mehrere Beispiele verwiesen wird.
As part of the Clash of Realities International Conference on the Technology and Theory of Digital Games, the Game Technology Summit is a premium venue to bring together experts from academia and industry to disseminate state-of-the-art research on trending technology topics in digital games. In this first iteration of the Game Technology Summit, we specifically paid attention on how the successes in AI in Natural User Interfaces have been impacting the games industry (industry track) and which scientific, state-of-the-art ideas and approaches are currently pursued (scientific track).
Introduction: The prognosis of medullary thyroid carcinoma (MTC) is poor using common chemotherapeutic approaches. However, during the last years encouraging results of recently introduced tyrosine kinase inhibitors (TKI) such as vandetanib have been published. In this study we aimed to correlate the results of \(^{18}\)F-fluorodeoxyglucose ([\(^{18}\)F]FDG) positron emission tomography (PET) imaging with treatment outcome.
Methods: Eighteen patients after thyroidectomy with recurrent/advanced MTC lesions receiving vandetanib (300 mg orally/day) could be analysed. A baseline \(^{18}\)F-FDG PET prior to and a follow-up \(^{18}\)F-FDG PET 3 months after TKI initiation were performed. During follow-up, tumor progression was assessed every 3 months including computed tomography according to RECIST. Progression-free survival (PFS) was correlated with the maximum standardized uptake value of \(^{18}\)F-FDG in lymph nodes (SUV(LN)max) or visceral metastases (SUV(MTS)max) as well as with clinical parameters using ROC analysis.
Results: Within median 3.6 years of follow-up, 9 patients showed disease progression at median 8.5 months after TKI initiation. An elevated glucose consumption assessed by baseline \(^{18}\)F-FDG PET (SUV(LN)max > 7.25) could predict a shorter PFS (2 y) with an accuracy of 76.5% (SUV(LN)max <7.25, 4.3 y; p=0.03). Accordingly, preserved tumor metabolism in the follow-up PET (SUV(MTS)max >2.7) also demonstrated an unfavorable prognosis (accuracy, 85.7%). On the other hand, none of the clinical parameters reached significance in response prediction.
Conclusions: In patients with advanced and progressive MTC, tumors with higher metabolic activity at baseline are more aggressive and more prone to progression as reflected by a shorter PFS; they should be monitored more closely. Preserved glucose consumption 3 months after treatment initiation was also related to poorer prognosis.
Pour faire la lumiere as lais? Mittelalterliche Handbücher des Glaubenswissens und ihr Publikum.
(1987)
No abstract available
Natural walking in virtual reality games is constrained by the physical boundaries defined by the size of the player’s tracking space. Impossible spaces, a redirected walking technique, enlarge the virtual environment by creating overlapping architecture and letting multiple locations occupy the same physical space. Within certain thresholds, this is subtle to the player. In this paper, we present our approach to implement such impossible spaces and describe how we handled challenges like objects with simulated physics or precomputed global illumination.
On the existence of arrested transcriptional machinery in late stages of avian erythropoiesis
(1976)
No abstract available
No abstract available
Non-Formal Education
(1989)