Refine
Has Fulltext
- yes (88)
Is part of the Bibliography
- yes (88) (remove)
Year of publication
- 2016 (88) (remove)
Document Type
- Journal article (88) (remove)
Keywords
- DNA methylation (3)
- Drosophila (3)
- Drosophila melanogaster (3)
- biodiversity (3)
- circadian rhythms (3)
- vision (3)
- DNA damage (2)
- Spermatogenesis (2)
- biological locomotion (2)
- breast cancer (2)
- circadian clock (2)
- cytotoxicity (2)
- database (2)
- gastric cancer (2)
- gene expression (2)
- genome (2)
- honey bees (2)
- host-pathogen interactions (2)
- insect brain (2)
- lung cancer (2)
- natural language processing (2)
- neurons (2)
- next generation sequencing (2)
- photoperiodism (2)
- phylogenetic trees (2)
- sexual selection (2)
- visualization (2)
- AP-1 (1)
- Action potentials (1)
- Acyrthosiphon pisum (1)
- Agricultural intensification (1)
- Alvis (1)
- Alzheimers disease (1)
- Amphibians (1)
- Amyotrophic-lateral-sclerosis (1)
- Angiopoietin-2 (1)
- Angiopoietin-like 4 (1)
- Annotation (1)
- Arabidopsis-thaliana (1)
- Arthropods (1)
- Autism (1)
- Autism spectrum disorders (1)
- Axon degeneration (1)
- Axonal transport (1)
- Bacterial symbionts (1)
- Bee abundance (1)
- Bone disease (1)
- Cancer genetics (1)
- Candida albicans (1)
- Cervical cancer (1)
- ChIP-sequencing (1)
- Chromosomes (1)
- Cimex lectularius (1)
- Cocalodinae (1)
- Coleoptera: Chrysomelidae (1)
- Colony growth (1)
- Context (1)
- Cytotoxic (1)
- DNA methylation dynamics (1)
- DNA-based species delimitation (1)
- Danio-rerio (1)
- Densities (1)
- Dionaea-muscipula ellis (1)
- Down syndrome (1)
- Drosha (1)
- E3 ligase (1)
- Ecologically important traits (1)
- Endothelial growth-factor (1)
- Environment (1)
- Epidermal growth-factor (1)
- Epigenetics (1)
- Epitope (1)
- Event (1)
- Exosome (1)
- FISH-CLEM (1)
- FWGE (1)
- Fetal brain development (1)
- Flow cytometry (1)
- Foragers (1)
- Frontal cortex (1)
- Gene (1)
- Gene expression profiling (1)
- Gene-expression (1)
- Genetics research (1)
- Genome (1)
- Genome assembly (1)
- Genome comparison (1)
- Genomics data sets (1)
- HKT transporter (1)
- HPV (1)
- Habitats (1)
- Horizontal transfer (1)
- Human prefrontal cortex (1)
- Hymenoptera (1)
- Insect hosts (1)
- Insects (1)
- Interactive Tree Of Life (iTOL) (1)
- Intermediate filaments (1)
- Jasmonate perception (1)
- LASP1 (1)
- Lacking neurofilaments (1)
- Lepidoptera (1)
- Locomotor activity (1)
- Locus (1)
- Lynx lynx (1)
- MDSCs (1)
- MIZ1 (1)
- MYC (1)
- MYCN (1)
- Male intromittent organ (1)
- Mechanisms (1)
- Meiosis (1)
- Mesenchymal stem cells (1)
- Mesocestoides corti (1)
- Methylome (1)
- Microorganisms (1)
- Microtubules (1)
- Missense mutation (1)
- Motoneuron disease (1)
- Mouse model (1)
- Mt. Kinabalu (1)
- Multiple myeloma (1)
- Mutations (1)
- NGS (1)
- NMD (1)
- NO (1)
- Nanda-Hamner (1)
- Nasonia courtship (1)
- Natural Language Processing (1)
- Nesting resources (1)
- Neurofilament (1)
- Nurses (1)
- Oilseed rape (1)
- Oogenesis (1)
- Opsins (1)
- Osteogenic precursor cells (1)
- PICD (1)
- Pain (1)
- Patterns (1)
- Peptidoglycan recognition (1)
- Plant utricularia-gibba (1)
- Podocarpus National Park (1)
- Poecilia reticulata (1)
- Polistine wasps (1)
- Polycistronic mRNA (1)
- Poor-prognosis (1)
- Primary endosymbiont (1)
- Programmed cell-death (1)
- Progressive motor neuronopathy (1)
- QTL analysis (1)
- RNA interference (1)
- RNA-SEQ data (1)
- RNAseq (1)
- Relapse (1)
- Reproduction (1)
- Reveals (1)
- Rhodopsins (1)
- Richness (1)
- SCD (1)
- Saccharomyces cerevisiae (1)
- Schizophrenia (1)
- Si-rhodamine (1)
- Single nucleotide change (1)
- Social entrainment (1)
- Staphylococcus aureus (1)
- Stat3 (1)
- Stathmin (1)
- Stress responses (1)
- T lymphocytes (1)
- Temperature rhythms (1)
- Text analysis (1)
- Textanalyse (1)
- Transcription (1)
- Transcriptome (1)
- Transgenic mice (1)
- Transovarial transmission (1)
- Trinidadian guppy (1)
- Trypanosoma brucei (1)
- Trypanosomes (1)
- VACV (1)
- Vaccine (1)
- WDR5 (1)
- Wallemia ichthyophaga (1)
- Williamsia sp. ARP1 (1)
- Wonderful plants (1)
- X. couchianus (1)
- X. hellerii (1)
- Xiphophorus (1)
- Xiphophorus fish (1)
- Yield (1)
- Zebrafish (1)
- achaete-scute homolog 1 (1)
- adaption (1)
- adipose (1)
- adipose tissue (1)
- adipose tissue dysfunction (1)
- adjuvant (1)
- agri-environment schemes (1)
- algorithm (1)
- anastomotic leakage (1)
- angiogenesis (1)
- angiogenic cytokines (1)
- animal behavior (1)
- animals (1)
- annotation (1)
- ant-mimicking spiders (1)
- anterior optic tubercle (1)
- anthropogenic activities (1)
- antimycotics (1)
- antioxidants (1)
- antitumor immune response (1)
- antiviral immunity (1)
- ants (1)
- apoptosis (1)
- arabidopsis (1)
- arabidopsis thaliana (1)
- army ants (1)
- artificial diet (1)
- assembly (1)
- astrocytes (1)
- attraction (1)
- autophagy (1)
- bed bug (1)
- bee community (1)
- bees (1)
- behavioral conditioning (1)
- benzoquinone (1)
- bevacizumab (1)
- biodiversity assessment (1)
- bioenergetics (1)
- biofuels (1)
- bioinformatics (1)
- biomarker (1)
- blood (1)
- body weight (1)
- brain-injury (1)
- breast-cancer (1)
- brefeldin-a (1)
- broodtranslocation (1)
- bug riptortus-pedestris (1)
- c-Fos (1)
- caenorhabditis elegans (1)
- calyx (1)
- camponotus ants (1)
- cancer biology (1)
- cancer cells (1)
- canopy spiders (1)
- capacitance (1)
- cell biology (1)
- cell compartmentation (1)
- cell cycle and cell division (1)
- cell cycle arrest (1)
- cell death (1)
- cell differentiation (1)
- cell membranes (1)
- cell motility (1)
- cell staining (1)
- cellular imaging (1)
- central complex (1)
- central nervous system (1)
- chemotherapy (1)
- chromatin (1)
- chronobiology (1)
- climate factors (1)
- cognition (1)
- cognitive functions (1)
- colony survival (1)
- color vision (1)
- colorectal cancer (1)
- community ecology (1)
- complication (1)
- computer-assisted (1)
- confocal laser microscopy (1)
- correlative light and electron microscopy (1)
- crop pollination (1)
- cytokines (1)
- cytokinins (1)
- cytosol (1)
- cytostatic (1)
- damped-oscillator-model of photoperiodic clock (1)
- data mining/methods (1)
- depreissia decipiens (1)
- deuterostomes (1)
- developmental biology (1)
- diapause (1)
- dichthadiigynes (1)
- direct stochasticoptical reconstruction microscopy (1)
- draft genome (1)
- drug-minded protein (1)
- early diagnosis (1)
- early secretory pathway (1)
- ecosystem services (1)
- ectotherms (1)
- endemism (1)
- endoplasmic-reticulum (1)
- endosomes (1)
- endosponge (1)
- enzyme regulation (1)
- epithelial cells (1)
- ethanol (1)
- excretory-secretory (1)
- exocrine glands (1)
- export (1)
- extracellular matrix (1)
- female choice (1)
- fetal brain development (1)
- field boundaries (1)
- finger protein 11 (1)
- fish model (1)
- flagella (1)
- fluorescence recovery after photobleaching (1)
- fluorescent-probes (1)
- fluorophore (1)
- food consumption (1)
- foraging (1)
- forest edges (1)
- forest fragmentation (1)
- forest hedges (1)
- forest specialists (1)
- frontal cortex (1)
- fungicide (1)
- gap junction (1)
- gastrointestinal tract (1)
- gene-expression (1)
- genetic dissection (1)
- genetics (1)
- genotype (1)
- geographic biases (1)
- geographical variation (1)
- global dataset (1)
- gut microbiota (1)
- halophilic fungus (1)
- high resolution visualisation (1)
- high-osmolarity glycerol (HOG) (1)
- histone γH2AX (1)
- honeybee (1)
- host cells (1)
- hour-glass (1)
- hourglass clock (1)
- human (1)
- human ectoparasite (1)
- humans (1)
- hyperexpression techniques (1)
- hypothalamus (1)
- hypoxia-inducible factor 3A (1)
- iNOS (1)
- image data (1)
- image processing (1)
- immune response (1)
- immunoreactive neurons (1)
- in-vitro (1)
- inflammation (1)
- inflammatory bowel disease (1)
- innate immune system (1)
- innexins (1)
- insects (1)
- insulin (1)
- insulin resistance (1)
- intensification (1)
- interaction (1)
- intracellular membranes (1)
- jumping spiders (1)
- junction proteins (1)
- land-use change (1)
- landscape compositionv (1)
- leaf beetle (1)
- learning (1)
- legionary ants (1)
- light-induced gene expression (1)
- light-trapping (1)
- lipid desaturation (1)
- lipidomics (1)
- liver metastasis (1)
- lncRNAs (1)
- localization micoscopy (1)
- locomotor activity (1)
- lungfish (1)
- lymphocytes (1)
- mRNA (1)
- macroecology (1)
- macrophages (1)
- marrow stromal cells (1)
- mathematical modeling (1)
- matrix metalloproteinases (1)
- melanoma (1)
- meliponines (1)
- membrane biophysics (1)
- membrane proteins (1)
- memory (1)
- memory formation (1)
- mesenchymal stem-cells (1)
- metabolism (1)
- miRNAs (1)
- mice (1)
- microRNA (1)
- microglomeruli (1)
- microscopy (1)
- mitogen activated protein kinase (MAPK) (1)
- modeling (1)
- molecular biology (1)
- monoclonial gammopathy (1)
- monocytes (1)
- moths (1)
- mouse (1)
- mouse models (1)
- mouse-brain (1)
- multimodal (1)
- multiple sequence alignments (1)
- mushroom body (1)
- mutation detection (1)
- neoadjuvant (1)
- nervous-system (1)
- nervous-sytem (1)
- neural circuits (1)
- neural stem-cells (1)
- neurogenic locus notch homolog (1)
- neuroimaging (1)
- neuronal plasticity (1)
- neuropeptides (1)
- neutrophils (1)
- non-crop habitats (1)
- non-invasive biomarkers (1)
- nurses (1)
- obesity (1)
- olfaction (1)
- oncolytic virus therapy (1)
- oxidative stress (1)
- parasitic cell cycles (1)
- parasitic diseases (1)
- parasitic life cycles (1)
- parasitology (1)
- peripheral-blood (1)
- phenotype (1)
- phosphorylation (1)
- photoactivation (1)
- photoperiodic time mesurement (1)
- phototransduction (1)
- phyllosphere (1)
- physiological traits (1)
- piRNA (1)
- pitcher-plant mosquito (1)
- plasticity (1)
- polarization vision (1)
- potassium (1)
- precedes multiple-myeloma (1)
- prey selection (1)
- progenitors (1)
- promoter affinity (1)
- prostate cancer (1)
- protein phosphorylation (1)
- protein-protein interaction (1)
- proteomes (1)
- proteomic analysis (1)
- protocadherin gamma cluster (1)
- protophormia terraenovae (1)
- pyramidal neurons (1)
- queens (1)
- radiation sensitivity (1)
- rainforest (1)
- reactive oxygen species (1)
- receptor tyrosine kinase (1)
- receptor tyrosine kinases (1)
- recombinat-human-erythropoietin (1)
- reconstruction (1)
- reproductive character displacement (1)
- reproductive diapause (1)
- resolution limit (1)
- resource availability (1)
- retinal dystrophies (1)
- retinoblastoma protein (1)
- rhythmic components (1)
- risk factor (1)
- salinity stress (1)
- sampling bias (1)
- sampling method (1)
- sarcopterygian fish (1)
- semi-natural habitats (1)
- sequestration (1)
- serotonin transporter (1)
- sex pheromone (1)
- signal peptides (1)
- signaling (1)
- signaling pathway (1)
- single-molecule biophysics (1)
- sky-compass orientation (1)
- sleep (1)
- small RNA-sequencing (1)
- small cell lung cancer (1)
- sodium (1)
- software (1)
- speciation (1)
- species diversification (1)
- spillover (1)
- stalking predators (1)
- structure (1)
- structured illumination microscopy (1)
- super-resolution imaging (1)
- super-resolution microscopy (1)
- survival (1)
- swimming (1)
- synaptic connections (1)
- synapticplasticity (1)
- systemic inflammatory response syndrome (1)
- targets (1)
- taxonomic biases (1)
- taxonomy (1)
- temperature (1)
- thermal adaptation (1)
- tool (1)
- trafficking (1)
- trans-splicing (1)
- transcriptional profiling (1)
- transcriptome (1)
- transcriptome analysis (1)
- transposable elements (1)
- trisomy 21 (1)
- tropical ecology (1)
- trypanosoma brucei gambiense (1)
- undetermined significance (1)
- unstructured data (1)
- unstrukturierte Daten (1)
- urbanization (1)
- vertebrates (1)
- vesicles (1)
- viscosity (1)
- wasp-mimicking (1)
- whole genome duplications (1)
- whole genome sequencing (1)
- whole-genome shotgun sequencing (1)
- wild plant pollination (1)
- wyeomyia smithii (1)
- xylem loading (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (88) (remove)
Sonstige beteiligte Institutionen
Human papilloma virus (HPV) is the primary etiological agent responsible for cervical cancer in women. Although in total 16 high-risk HPV strains have been identified so far. Currently available commercial vaccines are designed by targeting mainly HPV16 and HPV18 viral strains as these are the most common strains associated with cervical cancer. Because of the high level of antigenic specificity of HPV capsid antigens, the currently available vaccines are not suitable to provide cross-protection from all other high-risk HPV strains. Due to increasing reports of cervical cancer cases from other HPV high-risk strains other than HPV16 and 18, it is crucial to design vaccine that generate reasonable CD8+ T-cell responses for possibly all the high-risk strains. With this aim, we have developed a computational workflow to identify conserved cross-clade CD8+ T-cell HPV vaccine candidates by considering E1, E2, E6 and E7 proteins from all the high-risk HPV strains. We have identified a set of 14 immunogenic conserved peptide fragments that are supposed to provide protection against infection from any of the high-risk HPV strains across globe.
Interactive Tree Of Life (http://itol.embl.de) is a web-based tool for the display, manipulation and annotation of phylogenetic trees. It is freely available and open to everyone. The current version was completely redesigned and rewritten, utilizing current web technologies for speedy and streamlined processing. Numerous new features were introduced and several new data types are now supported. Trees with up to 100,000 leaves can now be efficiently displayed. Full interactive control over precise positioning of various annotation features and an unlimited number of datasets allow the easy creation of complex tree visualizations. iTOL 3 is the first tool which supports direct visualization of the recently proposed phylogenetic placements format. Finally, iTOL's account system has been redesigned to simplify the management of trees in user-defined workspaces and projects, as it is heavily used and currently handles already more than 500,000 trees from more than 10,000 individual users.
The bacterial endosymbiont Blochmannia floridanus of the carpenter ant Camponotus floridanus contributes to its hosts' ontogeny via nutritional upgrading during metamorphosis. This primary endosymbiosis is essential for both partners and vertical transmission of the endosymbionts is guaranteed by bacterial infestation of oocytes. Here we present a detailed analysis of the presence and localisation of B. floridanus in the ants' ovaries obtained by FISH and TEM analyses. The most apical part of the germarium harbouring germ-line stem cells (GSCs) is not infected by the bacteria. The bacteria are detectable for the first time in lower parts of the germarium when cystocytes undergo the 4th and 5th division and B. floridanus infects somatic cells lying under the basal lamina surrounding the ovarioles. With the beginning of cystocyte differentiation, the endosymbionts are exclusively transported from follicle cells into the growing oocytes. This infestation of the oocytes by bacteria very likely involves exocytosis endocytosis processes between follicle cells and the oocytes. Nurse cells were never found to harbour the endosymbionts. Furthermore we present first gene expression data in C floridanus ovaries. These data indicate a modulation of immune gene expression which may facilitate tolerance towards the endosymbionts and thus may contribute to their transovarial transmission.
Lungfish and coelacanths are the only living sarcopterygian fish. The phylogenetic relationship of lungfish to the last common ancestor of tetrapods and their close morphological similarity to their fossil ancestors make this species uniquely interesting. However their genome size, the largest among vertebrates, is hampering the generation of a whole genome sequence. To provide a partial solution to the problem, a high-coverage lungfish reference transcriptome was generated and assembled. The present findings indicate that lungfish, not coelacanths, are the closest relatives to land-adapted vertebrates. Whereas protein-coding genes evolve at a very slow rate, possibly reflecting a “living fossil” status, transposable elements appear to be active and show high diversity, suggesting a role for them in the remarkable expansion of the lungfish genome. Analyses of single genes and gene families documented changes connected to the water to land transition and demonstrated the value of the lungfish reference transcriptome for comparative studies of vertebrate evolution.
The Genome of the Trinidadian Guppy, Poecilia reticulata, and Variation in the Guanapo Population
(2016)
For over a century, the live bearing guppy, Poecilia reticulata, has been used to study sexual selection as well as local adaptation. Natural guppy populations differ in many traits that are of intuitively adaptive significance such as ornamentation, age at maturity, brood size and body shape. Water depth, light supply, food resources and predation regime shape these traits, and barrier waterfalls often separate contrasting environments in the same river. We have assembled and annotated the genome of an inbred single female from a high-predation site in the Guanapo drainage. The final assembly comprises 731.6 Mb with a scaffold N50 of 5.3 MB. Scaffolds were mapped to linkage groups, placing 95% of the genome assembly on the 22 autosomes and the X-chromosome. To investigate genetic variation in the population used for the genome assembly, we sequenced 10 wild caught male individuals. The identified 5 million SNPs correspond to an average nucleotide diversity (π) of 0.0025. The genome assembly and SNP map provide a rich resource for investigating adaptation to different predation regimes. In addition, comparisons with the genomes of other Poeciliid species, which differ greatly in mechanisms of sex determination and maternal resource allocation, as well as comparisons to other teleost genera can begin to reveal how live bearing evolved in teleost fish.
Depreissia is a little known genus comprising two hymenopteran-mimicking species, one found in Central Africa and one in the north of Borneo. The male of D. decipiens is redescribed, the female is described for the first time. The carapace is elongated, dorsally flattened and rhombus-shaped, the rear of the thorax laterally depressed and transformed, with a pair of deep pits; the pedicel is almost as long as the abdomen. The male palp is unusual, characterized by the transverse deeply split membranous tegulum separating a ventral part which bears a sclerotized tegular apophysis and a large dagger-like retrodirected median apophysis. The female epigyne consists of one pair of large adjacent spermathecae and very long copulatory ducts arising posteriorly and rising laterally alongside the spermathecae continuing in several vertical and horizontal coils over the anterior surface. Relationships within the Salticidae are discussed and an affinity with the Cocalodinae is suggested. Arguments are provided for a hypothesis that D. decipiens is not ant-mimicking as was previously believed, but is a mimic of polistinine wasps. The species was found in the canopy in the Kinabalu area only, in primary and old secondary rainforest at 200–700 m.a.s.l. Overlap of canopy-dwelling spider species with those in the understorey are discussed and examples of species richness and endemism in the canopy are highlighted. Canopy fogging is a very efficient method of collecting for most arthropods. The canopy fauna adds an extra dimension to the known biodiversity of the tropical rainforest. In southeast Asia, canopy research has been neglected, inhibiting evaluation of comparative results of this canopy project with that from other regions. More use of fogging as a collecting method would greatly improve insight into the actual species richness and species distribution in general.
Agricultural intensification often leads to fragmentation of natural habitats, such as forests, and thereby negatively affects forest specialist species. However, human introduced habitats, such as hedges, may counteract negative effects of forest fragmentation and increase dispersal, particularly of forest specialists. We studied effects of habitat type (forest edge versus hedge) and hedge isolation from forests (connected versus isolated hedge) in agricultural landscapes on abundance, species richness and community composition of mice, voles and shrews in forest edges and hedges. Simultaneously to these effects of forest edge/hedge type we analysed impacts of habitat structure, namely percentage of bare ground and forest edge/hedge width, on abundance, species richness and community composition of small mammals. Total abundance and forest specialist abundance (both driven by the most abundant species Myodes glareolus, bank vole) were higher in forest edges than in hedges, while hedge isolation had no effect. In contrast, abundance of habitat generalists was higher in isolated compared to connected hedges, with no effect of habitat type (forest edge versus hedge). Species richness as well as abundance of the most abundant habitat generalist Sorex araneus (common shrew), were not affected by habitat type or hedge isolation. Decreasing percentage of bare ground and increasing forest edge/hedge width was associated with increased abundance of forest specialists, while habitat structure was unrelated to species richness or abundance of any other group. Community composition was driven by forest specialists, which exceeded habitat generalist abundance in forest edges and connected hedges, while abundances were similar to each other in isolated hedges. Our results show that small mammal forest specialists prefer forest edges as habitats over hedges, while habitat generalists are able to use unoccupied ecological niches in isolated hedges. Consequently even isolated hedges can be marginal habitats for forest specialists and habitat generalists and thereby may increase regional farmland biodiversity.
Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae
(2016)
Memory formation is a highly complex and dynamic process. It consists of different phases, which depend on various neuronal and molecular mechanisms. In adult Drosophila it was shown that memory formation after aversive Pavlovian conditioning includes—besides other forms—a labile short-term component that consolidates within hours to a longer-lasting memory. Accordingly, memory formation requires the timely controlled action of different neuronal circuits, neurotransmitters, neuromodulators and molecules that were initially identified by classical forward genetic approaches. Compared to adult Drosophila, memory formation was only sporadically analyzed at its larval stage. Here we deconstruct the larval mnemonic organization after aversive olfactory conditioning. We show that after odor-high salt conditioning larvae form two parallel memory phases; a short lasting component that depends on cyclic adenosine 3’5’-monophosphate (cAMP) signaling and synapsin gene function. In addition, we show for the first time for Drosophila larvae an anesthesia resistant component, which relies on radish and bruchpilot gene function, protein kinase C activity, requires presynaptic output of mushroom body Kenyon cells and dopamine function. Given the numerical simplicity of the larval nervous system this work offers a unique prospect for studying memory formation of defined specifications, at full-brain scope with single-cell, and single-synapse resolution.