Refine
Has Fulltext
- yes (24)
Is part of the Bibliography
- yes (24)
Document Type
- Journal article (23)
- Doctoral Thesis (1)
Keywords
- HNSCC (5)
- artificial intelligence (5)
- head and neck cancer (5)
- caloric restriction (3)
- deep learning (3)
- machine learning (3)
- prediction (3)
- ARONJ (2)
- HGF (2)
- Met (2)
- amino acid restriction (2)
- cancer metabolism (2)
- classification (2)
- mass spectrometry (2)
- methionine (2)
- osteonecrosis of the jaw (2)
- osteoradionecrosis (2)
- 2-DG (1)
- 2-deoxy-D-glucose (1)
- AMPK (1)
- Adult (1)
- CBCT (1)
- CD44 (1)
- COPD (1)
- Cephalometry (1)
- Compound 3k (1)
- DASA-58 (1)
- Dysgnathie (1)
- FasL (1)
- Fernröntgenseitenbild (1)
- Head (1)
- Kephalometrie (1)
- Kraniometrie (1)
- L929 (1)
- LC/MS (1)
- MRONJ (1)
- NFκB (1)
- OHIP-49 (1)
- ONJ (1)
- PD-L1 (1)
- PET (1)
- PKM2 (1)
- Rhabdomyosarcoma (1)
- SCCHN (1)
- SLC-family (1)
- SWLS (1)
- Spindle cell (1)
- Surgery (1)
- TNFα (1)
- TPCA1 (1)
- TXNIP (1)
- Volumentomographie (1)
- Warburg effect (1)
- X-ray (1)
- agar diffusion test (1)
- alveolar bone loss (1)
- amino acid (1)
- amino acid transporter (1)
- ampicillin (1)
- antibiotic bone concentration (1)
- antiresorptive drug-related osteonecrosis of the jaw (1)
- apoptosis (1)
- beta-lactam (1)
- bone loss (1)
- cancer (1)
- case report (1)
- cell vitality (1)
- cisplatin (1)
- complications (1)
- computer-aided (1)
- contact inhibition (1)
- craniofacial orthodontics (1)
- design (1)
- donor-site morbidity (1)
- energy restriction (1)
- fibroblast activation protein (1)
- fibula (1)
- frailty (1)
- free skin grafts (1)
- geriatric cancer patient (1)
- gingivitis (1)
- glucose restriction (1)
- glycolysis (1)
- graft (1)
- immune therapy (1)
- inflammation (1)
- inhibitor (1)
- intraosseous (1)
- ischemia (1)
- jaw bone (1)
- lateral radiograph (1)
- length of stay (1)
- liquid chromatography/mass spectrometry (1)
- low carb (1)
- low energy metabolism (1)
- lymph node (1)
- malocclusion (1)
- mandible (1)
- mandibular (1)
- manufacturing (CAD/CAM) (1)
- maxillofacial surgery (1)
- medication-related osteonecrosis of the jaw (1)
- metabolomics (1)
- methionine restriction (1)
- model (1)
- molecular imaging (1)
- multicentric (1)
- object detection (1)
- operative planning (1)
- oral functional capacity (1)
- oral health (1)
- oral health-related quality of life (1)
- oral microbiome (1)
- oral squamous cell carcinoma (1)
- oral-health-related quality of life (1)
- oro-antral communication (1)
- oro-antral fistula (1)
- oroantral fistula (1)
- oropharyngeal carcinoma (1)
- osteocutaneous (1)
- pN1 (1)
- perfusion culture (1)
- periodontitis (1)
- physical examination (1)
- planning (1)
- platelet-rich fibrin (1)
- preoperative (1)
- progression-free survival (1)
- proliferation (1)
- prospective (1)
- prosthetic rehabilitation (1)
- pseudocarcinomatous hyperplasia (1)
- quality of life (1)
- radial forearm flap (1)
- radiographic bone loss (1)
- radiotherapy (1)
- reconstruction (1)
- recurrent/metastatic head and neck squamous cell carcinoma (1)
- resection (1)
- satisfaction with life (1)
- surgery (1)
- survival (1)
- teeth extraction (1)
- three-dimensional imaging (1)
- tooth extraction (1)
- treatment benefit (1)
Institute
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (24)
- Comprehensive Cancer Center Mainfranken (4)
- Pathologisches Institut (3)
- Poliklinik für Zahnärztliche Prothetik (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Institut für Hygiene und Mikrobiologie (2)
- Institut für Pharmazie und Lebensmittelchemie (2)
- Medizinische Klinik und Poliklinik II (2)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (1)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (1)
Sonstige beteiligte Institutionen
To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all p ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach.
Reconstruction of the donor site after radial forearm flap harvesting is a common procedure in maxillofacial plastic surgery. It is normally carried out with split-thickness or full-thickness free skin grafts. Unfortunately, free skin graft transplantation faces wound healing impairments such as necrosis, (partial) graft loss, or tendon exposure. Several studies have investigated methods to reduce these impairments and demonstrated improvements if the wound bed is optimised, for example, through negative-pressure wound therapy or vacuum-assisted closure. However, these methods are device-dependent, expansive, and time-consuming. Therefore, the application of platelet-rich fibrin (PRF) to the wound bed could be a simple, cost-effective, and device-independent method to optimise wound-bed conditions instead. In this study, PRF membranes were applied between the wound bed and skin graft. Results of this study indicate improvements in the PRF versus non-PRF group (93.44% versus 86.96% graft survival, p = 0.0292). PRF applied to the wound bed increases graft survival and reduces impairments. A possible explanation for this is the release of growth factors, which stimulate angiogenesis and fibroblast migration. Furthermore, the solid PRF membranes act as a mechanical barrier (“lubrication” layer) to protect the skin graft from tendon motion. The results of this study support the application of PRF in donor-site reconstruction with free skin grafts.
Nonlimited proliferation is one of the most striking features of neoplastic cells. The basis of cell division is the sufficient presence of mass (amino acids) and energy (ATP and NADH). A sophisticated intracellular network permanently measures the mass and energy levels. Thus, in vivo restrictions in the form of amino acid, protein, or caloric restrictions strongly affect absolute lifespan and age-associated diseases such as cancer. The induction of permanent low energy metabolism (LEM) is essential in this process. The murine cell line L929 responds to methionine restriction (MetR) for a short time period with LEM at the metabolic level defined by a characteristic fingerprint consisting of the molecules acetoacetate, creatine, spermidine, GSSG, UDP-glucose, pantothenate, and ATP. Here, we used mass spectrometry (LC/MS) to investigate the influence of proliferation and contact inhibition on the energy status of cells. Interestingly, the energy status was essentially independent of proliferation or contact inhibition. LC/MS analyses showed that in full medium, the cells maintain active and energetic metabolism for optional proliferation. In contrast, MetR induced LEM independently of proliferation or contact inhibition. These results are important for cell behaviour under MetR and for the optional application of restrictions in cancer therapy.
Background: Oro-antral communication (OAC) is a common complication following the extraction of upper molar teeth. The Archer and the Root Sinus (RS) systems can be used to classify impacted teeth in panoramic radiographs. The Archer classes B-D and the Root Sinus classes III, IV have been associated with an increased risk of OAC following tooth extraction in the upper molar region. In our previous study, we found that panoramic radiographs are not reliable for predicting OAC. This study aimed to (1) determine the feasibility of automating the classification (Archer/RS classes) of impacted teeth from panoramic radiographs, (2) determine the distribution of OAC stratified by classification system classes for the purposes of decision tree construction, and (3) determine the feasibility of automating the prediction of OAC utilizing the mentioned classification systems. Methods: We utilized multiple supervised pre-trained machine learning models (VGG16, ResNet50, Inceptionv3, EfficientNet, MobileNetV2), one custom-made convolutional neural network (CNN) model, and a Bag of Visual Words (BoVW) technique to evaluate the performance to predict the clinical classification systems RS and Archer from panoramic radiographs (Aim 1). We then used Chi-square Automatic Interaction Detectors (CHAID) to determine the distribution of OAC stratified by the Archer/RS classes to introduce a decision tree for simple use in clinics (Aim 2). Lastly, we tested the ability of a multilayer perceptron artificial neural network (MLP) and a radial basis function neural network (RBNN) to predict OAC based on the high-risk classes RS III, IV, and Archer B-D (Aim 3). Results: We achieved accuracies of up to 0.771 for EfficientNet and MobileNetV2 when examining the Archer classification. For the AUC, we obtained values of up to 0.902 for our custom-made CNN. In comparison, the detection of the RS classification achieved accuracies of up to 0.792 for the BoVW and an AUC of up to 0.716 for our custom-made CNN. Overall, the Archer classification was detected more reliably than the RS classification when considering all algorithms. CHAID predicted 77.4% correctness for the Archer classification and 81.4% for the RS classification. MLP (AUC: 0.590) and RBNN (AUC: 0.590) for the Archer classification as well as MLP 0.638) and RBNN (0.630) for the RS classification did not show sufficient predictive capability for OAC. Conclusions: The results reveal that impacted teeth can be classified using panoramic radiographs (best AUC: 0.902), and the classification systems can be stratified according to their relationship to OAC (81.4% correct for RS classification). However, the Archer and RS classes did not achieve satisfactory AUCs for predicting OAC (best AUC: 0.638). Additional research is needed to validate the results externally and to develop a reliable risk stratification tool based on the present findings.