Refine
Has Fulltext
- yes (24)
Is part of the Bibliography
- yes (24)
Document Type
- Journal article (23)
- Doctoral Thesis (1)
Keywords
- HNSCC (5)
- artificial intelligence (5)
- head and neck cancer (5)
- caloric restriction (3)
- deep learning (3)
- machine learning (3)
- prediction (3)
- ARONJ (2)
- HGF (2)
- Met (2)
- amino acid restriction (2)
- cancer metabolism (2)
- classification (2)
- mass spectrometry (2)
- methionine (2)
- osteonecrosis of the jaw (2)
- osteoradionecrosis (2)
- 2-DG (1)
- 2-deoxy-D-glucose (1)
- AMPK (1)
- Adult (1)
- CBCT (1)
- CD44 (1)
- COPD (1)
- Cephalometry (1)
- Compound 3k (1)
- DASA-58 (1)
- Dysgnathie (1)
- FasL (1)
- Fernröntgenseitenbild (1)
- Head (1)
- Kephalometrie (1)
- Kraniometrie (1)
- L929 (1)
- LC/MS (1)
- MRONJ (1)
- NFκB (1)
- OHIP-49 (1)
- ONJ (1)
- PD-L1 (1)
- PET (1)
- PKM2 (1)
- Rhabdomyosarcoma (1)
- SCCHN (1)
- SLC-family (1)
- SWLS (1)
- Spindle cell (1)
- Surgery (1)
- TNFα (1)
- TPCA1 (1)
- TXNIP (1)
- Volumentomographie (1)
- Warburg effect (1)
- X-ray (1)
- agar diffusion test (1)
- alveolar bone loss (1)
- amino acid (1)
- amino acid transporter (1)
- ampicillin (1)
- antibiotic bone concentration (1)
- antiresorptive drug-related osteonecrosis of the jaw (1)
- apoptosis (1)
- beta-lactam (1)
- bone loss (1)
- cancer (1)
- case report (1)
- cell vitality (1)
- cisplatin (1)
- complications (1)
- computer-aided (1)
- contact inhibition (1)
- craniofacial orthodontics (1)
- design (1)
- donor-site morbidity (1)
- energy restriction (1)
- fibroblast activation protein (1)
- fibula (1)
- frailty (1)
- free skin grafts (1)
- geriatric cancer patient (1)
- gingivitis (1)
- glucose restriction (1)
- glycolysis (1)
- graft (1)
- immune therapy (1)
- inflammation (1)
- inhibitor (1)
- intraosseous (1)
- ischemia (1)
- jaw bone (1)
- lateral radiograph (1)
- length of stay (1)
- liquid chromatography/mass spectrometry (1)
- low carb (1)
- low energy metabolism (1)
- lymph node (1)
- malocclusion (1)
- mandible (1)
- mandibular (1)
- manufacturing (CAD/CAM) (1)
- maxillofacial surgery (1)
- medication-related osteonecrosis of the jaw (1)
- metabolomics (1)
- methionine restriction (1)
- model (1)
- molecular imaging (1)
- multicentric (1)
- object detection (1)
- operative planning (1)
- oral functional capacity (1)
- oral health (1)
- oral health-related quality of life (1)
- oral microbiome (1)
- oral squamous cell carcinoma (1)
- oral-health-related quality of life (1)
- oro-antral communication (1)
- oro-antral fistula (1)
- oroantral fistula (1)
- oropharyngeal carcinoma (1)
- osteocutaneous (1)
- pN1 (1)
- perfusion culture (1)
- periodontitis (1)
- physical examination (1)
- planning (1)
- platelet-rich fibrin (1)
- preoperative (1)
- progression-free survival (1)
- proliferation (1)
- prospective (1)
- prosthetic rehabilitation (1)
- pseudocarcinomatous hyperplasia (1)
- quality of life (1)
- radial forearm flap (1)
- radiographic bone loss (1)
- radiotherapy (1)
- reconstruction (1)
- recurrent/metastatic head and neck squamous cell carcinoma (1)
- resection (1)
- satisfaction with life (1)
- surgery (1)
- survival (1)
- teeth extraction (1)
- three-dimensional imaging (1)
- tooth extraction (1)
- treatment benefit (1)
Institute
- Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie (24)
- Comprehensive Cancer Center Mainfranken (4)
- Pathologisches Institut (3)
- Poliklinik für Zahnärztliche Prothetik (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Institut für Hygiene und Mikrobiologie (2)
- Institut für Pharmazie und Lebensmittelchemie (2)
- Medizinische Klinik und Poliklinik II (2)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (1)
- Klinik und Poliklinik für Hals-, Nasen- und Ohrenkrankheiten, plastische und ästhetische Operationen (1)
Sonstige beteiligte Institutionen
In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 new cases diagnosed annually worldwide. With a 5-year survival rate of approximately 55%, the poor prognosis has not improved despite extensive research and new adjuvant therapies. Therefore, for the first time, we analysed the potential of methionine restriction (MetR) in selected HNSCC cell lines. We investigated the influence of MetR on cell proliferation and vitality, the compensation for MetR by homocysteine, the gene regulation of different amino acid transporters, and the influence of cisplatin on cell proliferation in different HNSCC cell lines.