Refine
Has Fulltext
- yes (21)
Is part of the Bibliography
- yes (21) (remove)
Year of publication
Document Type
- Journal article (20)
- Doctoral Thesis (1)
Keywords
- Aspergillus (3)
- Candida albicans (3)
- Aspergillus fumigatus (2)
- Candida auris (2)
- Fusarium (2)
- Rhizopus (2)
- cell wall (2)
- fungal infection (2)
- Alternaria (1)
- AurisID (1)
Institute
- Institut für Hygiene und Mikrobiologie (16)
- Medizinische Klinik und Poliklinik II (10)
- Theodor-Boveri-Institut für Biowissenschaften (2)
- Augenklinik und Poliklinik (1)
- Institut für Allgemeinmedizin (1)
- Institut für Molekulare Infektionsbiologie (1)
- Institut für Virologie und Immunbiologie (1)
- Kinderklinik und Poliklinik (1)
- Medizinische Klinik und Poliklinik I (1)
EU-Project number / Contract (GA) number
- 2016 FGR 0053 (1)
- 847507 (1)
Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity
(2023)
Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal, Gram-negative or Gram-positive bacterial pathogens. We identify conserved monocyte responses to bacterial pathogens and a distinct antifungal response. These include 745 response eQTLs (reQTLs) and corresponding genes with pathogen-specific effects, which we find first in samples of male donors and subsequently confirm for selected reQTLs in females. reQTLs affect predominantly upregulated genes that regulate immune response via e.g., NOD-like, C-type lectin, Toll-like and complement receptor-signaling pathways. Hence, reQTLs provide a functional explanation for individual differences in innate response patterns. Our identified reQTLs are also associated with cancer, autoimmunity, inflammatory and infectious diseases as shown by external genome-wide association studies. Thus, reQTLs help to explain interindividual variation in immune response to infection and provide candidate genes for variants associated with a range of diseases.