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  • 2017 (2) (remove)

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  • Klinik und Poliklinik für Nuklearmedizin (2) (remove)

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Whitening and impaired glucose utilization of brown adipose tissue in a rat model of type 2 diabetes mellitus (2017)
Lapa, Constantin ; Arias-Loza, Paula ; Hayakawa, Nobuyuki ; Wakabayashi, Hiroshi ; Werner, Rudolf A. ; Chen, Xinyu ; Shinaji, Tetsuya ; Herrmann, Ken ; Pelzer, Theo ; Higuchi, Takahiro
Brown adipose tissue (BAT) is an attractive therapeutic target to combat diabetes and obesity due to its ability to increase glucose expenditure. In a genetic rat model (ZDF fa/fa) of type-2 diabetes and obesity, we aimed to investigate glucose utilization of BAT by \(^{18}\)F-FDG PET imaging. Male Zucker diabetic fatty (ZDF) and Male Zucker lean (ZL) control rats were studied at 13 weeks. Three weeks prior to imaging, ZDF rats were randomized into a no-restriction (ZDF-ND) and a mild calorie restriction (ZDF-CR) group. Dynamic \(^{18}\)F-FDG PET using a dedicated small animal PET system was performed under hyperinsulinemic-euglycemic clamp. \(^{18}\)F-FDG PET identified intense inter-scapular BAT glucose uptake in all ZL control rats, while no focally increased \(^{18}\)F-FDG uptake was detected in all ZDF-ND rats. Mild but significant improved BAT tracer uptake was identified after calorie restriction in diabetic rats (ZDF-CR). The weight of BAT tissue and fat deposits were significantly increased in ZDF-CR and ZDF-ND rats as compared to ZL controls, while UCP-1 and mitochondrial concentrations were significantly decreased. Whitening and severely impaired insulin-stimulated glucose uptake in BAT was confirmed in a rat model of type-2 diabetes. Additionally, calorie restriction partially restored the impaired BAT glucose uptake.
Intracellular behavior of the novel sympathetic nerve agent \(^{18}\)F-LMI1195 (2017)
Werner, Rudolf ; Chen, Xinyu ; Lapa, Constantin ; Robinson, Simon ; Higuchi, Takahiro
No abstract available.
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