Refine
Has Fulltext
- yes (91)
Is part of the Bibliography
- yes (91)
Year of publication
Document Type
- Journal article (77)
- Conference Proceeding (8)
- Preprint (6)
Keywords
- PET (26)
- Positronen-Emissions-Tomografie (20)
- positron emission tomography (15)
- theranostics (12)
- CXCR4 (9)
- PET/CT (9)
- PRRT (9)
- multiple myeloma (9)
- molecular imaging (8)
- neuroendocrine tumor (8)
- prostate cancer (7)
- PSMA (6)
- SPECT (6)
- SSTR (6)
- RADS (5)
- somatostatin receptor (5)
- 18F-FDG (4)
- 18F-DCFPyL (3)
- 18F-LMI1195 (3)
- DaTscan (3)
- FDG (3)
- NET (3)
- Prostate Cancer (3)
- ageing (3)
- chemokine receptor (3)
- medicine (3)
- norepinephrine transporter (3)
- peptide receptor radionuclide therapy (3)
- prostate-specific membrane antigen (3)
- radioligand therapy (3)
- sympathetic nervous system (3)
- vandetanib (3)
- 11C-HED (2)
- 18F-FDG PET/CT (2)
- 18F-FDS (2)
- 68Ga-DOTATATE (2)
- DOTATOC (2)
- ECG (2)
- Ioflupane (2)
- MAG3 (2)
- MIBG (2)
- Multiple myeloma (2)
- Neuroendocrine Tumor (2)
- PSMA-PET (2)
- PSMA-RADS (2)
- Parkinson (2)
- Parkinson Disease (2)
- Parkinson-Krankheit (2)
- Positron Emission Tomography (2)
- Positron emission tomography (2)
- SSTR-RADS (2)
- Stammzelle (2)
- TKI (2)
- Virchow Node (2)
- [177Lu]-DOTATATE/-DOTATOC (2)
- [68Ga] (2)
- antidepressant (2)
- bone disease (2)
- cardiomyocytes (2)
- diabetes (2)
- fatty acid (2)
- fibroblast activation protein (2)
- glioblastoma (2)
- glioblastoma multiforme (2)
- heart failure (2)
- hiPSC-CM (2)
- induced pluripotent stem cells (2)
- kidney (2)
- medullary thyroid carcinoma (2)
- molecular medicine (2)
- myocardial sympathetic innervation imaging (2)
- personalized medicine (2)
- personalized treatment (2)
- precision medicine (2)
- prostate-specific membrane antigen (PSMA) (2)
- radionuclide therapy (2)
- relapse (2)
- reporting and data system (2)
- sarcoidosis (2)
- stem cell therapy (2)
- survival (2)
- tracer (2)
- tumor heterogeneity (2)
- tyrosine kinase inhibitor (2)
- 11C-Hydroxyephedrine (1)
- 11C-Methionine PET/CT (1)
- 11C-hydroxyephedrine (1)
- 123I-Ioflupane (1)
- 123I-mIBG (1)
- 123I-metaiodobenzylguanidine (1)
- 177Lu (1)
- 177Lu-DOTATATE (1)
- 177Lu-DOTATOC (1)
- 18F-DCFPL (1)
- 18F-flurpiridaz (1)
- 18FDG-PET/CT (1)
- 18FFBnTP (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 53BP1 (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE/-TOC (1)
- 68Ga-DOTATOC (1)
- 68Ga-PSMA ligand PET/CT (1)
- 68Ga-Pentixafor PET/CT (1)
- 99mTc-DTPA (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- Antibodies (1)
- Antidepressants (1)
- Arginine (1)
- Atherosclerotic plaque (1)
- BRAF mutation (1)
- C-11-methionine pet (1)
- C-X-C motif chemokine receptor 4 (1)
- CD38 (1)
- CXCR4/SDF-1 (1)
- Capicua transcriptional repressor (1)
- Cardiovascular diseases (1)
- Cardiovascular risk factors (1)
- DNA double-strand breaks (1)
- DOTA-EB-TATE (1)
- Diabetes (1)
- Drug resistance (1)
- ECG-gated (1)
- EKG (1)
- Extramedullary disease (1)
- F-18-FDG PET (1)
- FDG PET/CT (1)
- FDG-PET/CT (1)
- GI (1)
- Ga-68 (1)
- Ganglia (1)
- Gastrointestinal (1)
- Glomerular filtration (1)
- HFmrEF (1)
- HMDP hydroxymethylene diphosphonate (1)
- Heart failure (1)
- Herz (1)
- Hyperkalaemia (1)
- IDH1/2 (1)
- Imaging pitfalls (1)
- Lysine (1)
- MDD (1)
- MI-RADS (1)
- MIBG scintigraphy (1)
- MOR202 (1)
- MPI (1)
- MRI (1)
- Macrophage (1)
- Medizin (1)
- Medullärer Schilddrüsenkrebs (1)
- Merkel cell carcinoma (1)
- Metaiodobenzylguanidine (1)
- Molecular imaging (1)
- Myeloma cells (1)
- Myelomas (1)
- Myocardial-perfusion SPECT (1)
- Myokarditis (1)
- NEC (1)
- Neuroendocrine (1)
- Nierenfunktionsstörung (1)
- Oncology (1)
- PROMISE (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Pancreas (1)
- Parkinson's disease (1)
- Parkinsonism (1)
- Parkinson’s disease (1)
- Pentixafor (1)
- Pitfall (1)
- Positron-Emission Tomography (1)
- Positronenemissionstomografie (1)
- Prostata (1)
- Radiofluorine (1)
- Radionuclide Therapy (1)
- Radiotracer (1)
- SOAT1 (1)
- SPECT Scanner (1)
- SPECT/CT (1)
- SSTR-PET (1)
- SUV (1)
- Single-Photon-Emissions-Computertomographie (1)
- Sodium-Glucose Cotransporters (SGLTs) (1)
- Somatostatin receptor (1)
- Somatostatin receptor expression (1)
- Standardisierung (1)
- T-shaped π-π stacking (1)
- T-shaped π–π stacking (1)
- Tracer (1)
- ZDF rats (1)
- [177Lu]/[90Y]PentixaTher (1)
- [68Ga]DOTATOC (1)
- [68Ga]PentixaFor (1)
- [68Ga]Pentixafor (1)
- [\(^{68}\)Ga] pentixafor (1)
- [\(^{68}\)Ga]Ga-FAPI (1)
- [\(^{68}\)Ga]Pentixafor (1)
- \(^{11}\)C-Methionine-PET (1)
- \(^{11}\)C-methionine (1)
- \(^{18}\)F (1)
- \(^{18}\)F-FDG (1)
- \(^{18}\)F-FDG PET/CT (1)
- \(^{18}\)F-fluorodeoxyglucose (1)
- \(^{68}\)Ga (1)
- \(^{68}\)Ga-Pentixafor (1)
- accuracy (1)
- agreement (1)
- amino acids (1)
- androgen deprivation therapy (1)
- angiogenesis (1)
- antidepressants (1)
- astrocytoma (1)
- autologous transplantation (1)
- autonomic nervous system (1)
- benzylguanidine (1)
- biokinetics (1)
- biomarker (1)
- biomarkers (1)
- biosynthesis (1)
- bone marrow cells (1)
- brain (1)
- brain tumors (1)
- cancer (1)
- cardiac (1)
- cardiac innervation imaging (1)
- cardiac neurohormonal system (1)
- cardiac sympathetic nerve system (1)
- cardiac sympathetic nervous system (1)
- cell staining (1)
- cells (1)
- cerebral gliomas (1)
- chemokine receptor-4 (1)
- clinical diagnosis (1)
- collimator (1)
- comparability (1)
- contrast agent (1)
- coronary artery disease (1)
- criteria (1)
- daratumumab (1)
- delineation (1)
- dementia (1)
- depression (1)
- detection rate (1)
- diabetic cardiomyopathy (1)
- diabetische Kardiomyopathie (1)
- diffusion weighted mri (1)
- disease (1)
- dosimetry (1)
- ejection fraction (1)
- endocrinology (1)
- endoradiotherapy (1)
- esophagogastric junction (1)
- evans blue (1)
- experience (1)
- extramedullary hematopoiesis (1)
- glioma (1)
- glomerular filtration rate (1)
- guidelines (1)
- head and neck cancer (1)
- heart (1)
- heart failure with mid-range ejection fraction (1)
- heart-to-mediastinum ratio (1)
- high risk (1)
- hydroxyephedrine (1)
- hyperkalemia (1)
- imaging (1)
- imaging techniques (1)
- immune infiltration (1)
- immunostaining (1)
- improves (1)
- in vivo imaging (1)
- inflammation (1)
- interobserver (1)
- interreader (1)
- intraindividual comparison (1)
- involvement (1)
- kidney function (1)
- left-ventricular function (1)
- lesions (1)
- linear conversion (1)
- lipid droplets (1)
- mIBG (1)
- mRNA (1)
- machine learning (1)
- macrophages (1)
- magnetic resonance imaging (1)
- major depressive disorder (1)
- malignancies (1)
- management (1)
- medium-sized animals (1)
- metabolic tumor volume (MTV) (1)
- metabolic tumour volume (MTV) (1)
- methionine (1)
- methionine pet (1)
- miRNA (1)
- microenvironment (1)
- microglial cells (1)
- mitotane (1)
- mouse (1)
- moycardial sympathetic innervation (1)
- multiple system atrophy (1)
- myocardial perfusion imaging (1)
- myocarditis (1)
- nephrology (1)
- neuroendocrine neoplasia (1)
- nonhuman primates (1)
- nuclear cardiology (1)
- nuclear medicine (1)
- ollimator (1)
- organic cation transporter (1)
- pancreas (1)
- pattern (1)
- peptide receptor (1)
- performance (1)
- peripheral nervous system (1)
- phaeochromocytoma (1)
- phenethylguanidine (1)
- pleural mesothelioma (1)
- positron emission tomography/computed tomography (1)
- positron-emission-tomography (1)
- post-reconstruction filtering (1)
- progression (1)
- quality (1)
- quantification (1)
- radiogenomics (1)
- radiotherapy (1)
- radiotracer (1)
- radiotracer kinetics (1)
- rats (1)
- recurrent prostate cancer (1)
- refractory (1)
- renal (1)
- renal failure (1)
- renal function (1)
- renal imaging (1)
- renal scintigraphy (1)
- reporting and data systems (1)
- risk (1)
- scanner (1)
- single photon emission computed tomography: sympathetic nerve (1)
- skeletal (1)
- skin biopsy (1)
- small animal SPECT (1)
- small-animal imaging (1)
- smoldering myeloma (1)
- software (1)
- solid tumors (1)
- somatostatin (1)
- somatostatin receptor (SSTR) (1)
- somatostatin receptors (1)
- spleen (1)
- split renal function (1)
- standardization (1)
- standardized reporting (1)
- stem cells (1)
- stem-cell research (1)
- stem-cell transplantation (1)
- stimulation (1)
- storage vesicle turnover (1)
- structure–activity relationships (1)
- sympathetic nerve (1)
- targeted therapy (1)
- total lesion PSMA (1)
- total lesion glycolysis (TLG) (1)
- total lesion methionine uptake (TLMU) (1)
- transcriptome (1)
- treatment response (1)
- tumor burden (1)
- tumor microenvironment (1)
- unilateral ureteral obstruction (1)
- urology (1)
- vestibular schwannoma (1)
- γ-H2AX (1)
Institute
- Klinik und Poliklinik für Nuklearmedizin (88)
- Medizinische Klinik und Poliklinik II (19)
- Medizinische Klinik und Poliklinik I (11)
- Pathologisches Institut (10)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (8)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (8)
- Urologische Klinik und Poliklinik (4)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (3)
- Comprehensive Cancer Center Mainfranken (3)
- Institut für Anatomie und Zellbiologie (3)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (16)
- Johns Hopkins University School of Medicine (5)
- Johns Hopkins School of Medicine, Baltimore, MD, U.S. (3)
- Department of Biomedical Imaging, National Cerebral and Cardiovascular Research Center, Suita, Japan (2)
- Division of Medical Technology and Science, Department of Medical Physics and Engineering, Course of Health Science, Osaka University Graduate School of Medicine, Suita Japan (2)
- Institut for Molecular Biology and CMBI, Department of Genomics, Stem Cell Biology and Regenerative Medicine, Leopold-Franzens-University Innsbruck, Innsbruck, Austria (2)
- Johns Hopkins School of Medicine, The Russell H Morgan Department of Radiology and Radiological Science, Baltimore, MD, USA (2)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (1)
- Department of Nuclear Medicine, Kanazawa University (1)
- Hospital Augsburg, Augsburg, Germany (1)
EU-Project number / Contract (GA) number
- 701983 (35)
We aimed to investigate the image quality of the U-SPECT5/CT E-Class a micro single-photon emission computed tomography (SPECT) system with two large stationary detectors for visualization of rat hearts and bones using clinically available \(^{99m}\)Tc-labelled tracers. Sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR) of the small-animal SPECT scanner were investigated in phantom studies using an ultra-high-resolution rat and mouse multi-pinhole collimator (UHR-RM). Point source, hot-rod, and uniform phantoms with \(^{99m}\)Tc-solution were scanned for high-count performance assessment and count levels equal to animal scans, respectively. Reconstruction was performed using the similarity-regulated ordered-subsets expectation maximization (SROSEM) algorithm with Gaussian smoothing. Rats were injected with similar to 100 MBq [\(^{99m}\)TcTc-MIBI or similar to 150 MBq [\(^{99m}\)Tc]Tc-HMDP and received multi-frame micro-SPECT imaging after tracer distribution. Animal scans were reconstructed for three different acquisition times and post-processed with different sized Gaussian filters. Following reconstruction, CNR was calculated and image quality evaluated by three independent readers on a five-point scale from 1="very poor" to 5="very good". Point source sensitivity was 567 cps/MBq and radioactive rods as small as 1.2 mm were resolved with the UHR-RM collimator. Collimator-dependent uniformity was 55.5%. Phantom CNR improved with increasing rod size, filter size and activity concentration. Left ventricle and bone structures were successfully visualized in rat experiments. Image quality was strongly affected by the extent of post-filtering, whereas scan time did not have substantial influence on visual assessment. Good image quality was achieved for resolution range greater than 1.8 mm in bone and 2.8 mm in heart. The recently introduced small animal SPECT system with two stationary detectors and UHR-RM collimator is capable to provide excellent image quality in heart and bone scans in a rat using standardized reconstruction parameters and appropriate post-filtering. However, there are still challenges in achieving maximum system resolution in the sub-millimeter range with in vivo settings under limited injection dose and acquisition time.