Refine
Has Fulltext
- yes (42)
Is part of the Bibliography
- yes (42)
Document Type
- Journal article (36)
- Preprint (4)
- Conference Proceeding (2)
Language
- English (42)
Keywords
- Positronen-Emissions-Tomografie (13)
- PET (10)
- prostate cancer (10)
- theranostics (8)
- positron emission tomography (7)
- PSMA (6)
- RADS (5)
- prostate-specific membrane antigen (5)
- CXCR4 (4)
- PET/CT (4)
- PSMA-RADS (4)
- SPECT (4)
- molecular imaging (4)
- neuroendocrine tumor (4)
- radioligand therapy (4)
- 18F-DCFPyL (3)
- DaTscan (3)
- PRRT (3)
- Prostate Cancer (3)
- reporting and data system (3)
- somatostatin receptor (3)
- 18F-FDG (2)
- 18F-FDS (2)
- Ioflupane (2)
- MRI (2)
- PSMA-PET (2)
- Parkinson (2)
- Parkinson Disease (2)
- Parkinson-Krankheit (2)
- Positron Emission Tomography (2)
- SSTR (2)
- SSTR-RADS (2)
- Virchow Node (2)
- inflammation (2)
- kidney (2)
- medullary thyroid carcinoma (2)
- norepinephrine transporter (2)
- peptide receptor radionuclide therapy (2)
- personalized medicine (2)
- prostate-specific membrane antigen (PSMA) (2)
- somatostatin receptor (SSTR) (2)
- sympathetic nervous system (2)
- tyrosine kinase inhibitor (2)
- vandetanib (2)
- 11C-hydroxyephedrine (1)
- 123I-Ioflupane (1)
- 123I-metaiodobenzylguanidine (1)
- 18F-DCFPL (1)
- 18F-LMI1195 (1)
- 18F-flurpiridaz (1)
- 18FFBnTP (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 68Ga-DOTANOC (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATATE/-TOC (1)
- 68Ga-DOTATOC (1)
- 99mTc-DTPA (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- AI (1)
- C-X-C motif chemokine receptor 4 (1)
- CTCAE (1)
- Cardiovascular diseases (1)
- DCGAN (1)
- GAN (1)
- GCA (1)
- GI (1)
- Ganglia (1)
- Gastrointestinal (1)
- Gleason score (1)
- Glomerular filtration (1)
- HFmrEF (1)
- Heart failure (1)
- Imaging pitfalls (1)
- MI-RADS (1)
- MIBG (1)
- MPI (1)
- Magnetresonanztomografie (1)
- Medullärer Schilddrüsenkrebs (1)
- Myocardial-perfusion SPECT (1)
- NEC (1)
- NET (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- Nierenfunktionsstörung (1)
- Oncology (1)
- PMR (1)
- PROMISE (1)
- PSMA I&T (1)
- PSMA-617 (1)
- PSMA-RADS-3A (1)
- PSMA-RADS-3B (1)
- PSMA-targeted PET (1)
- Parkinsonism (1)
- Parkinson’s disease (1)
- Pentixafor (1)
- Pitfall (1)
- Positron-Emission Tomography (1)
- Positronenemissionstomografie (1)
- Prostata (1)
- RLT (1)
- Radiofluorine (1)
- Radionuclide Therapy (1)
- Radiotracer (1)
- SPECT/CT (1)
- SSTR-PET (1)
- SUV (1)
- Single-Photon-Emissions-Computertomographie (1)
- Sodium-Glucose Cotransporters (SGLTs) (1)
- Standardisierung (1)
- T-shaped π-π stacking (1)
- TKI (1)
- Tracer (1)
- [177Lu]/[90Y]PentixaTher (1)
- [177Lu]Lu-PSMA I&T (1)
- [18F]FDG PET/CT (1)
- [68Ga]DOTATOC (1)
- [68Ga]PentixaFor (1)
- [68Ga]Pentixafor (1)
- \(^{177}\)Lu (1)
- \(^{18}\)F (1)
- \(^{18}\)F-DCFPyL PET/CT (1)
- \(^{18}\)F-PSMA-1007 (1)
- \(^{68}\)Ga (1)
- ageing (1)
- artificial intelligence (1)
- biomarkers (1)
- blood flow (1)
- cardiac innervation imaging (1)
- cardiac nerve (1)
- chemokine receptor (1)
- coronary artery disease (1)
- diabetes (1)
- ejection fraction (1)
- endoradiotherapy (1)
- giant cell arteritis (1)
- glomerular filtration rate (1)
- heart failure with mid-range ejection fraction (1)
- hematotoxicity (1)
- interobserver (1)
- interreader (1)
- left-ventricular function (1)
- machine learning (1)
- magnetic resonance imaging (1)
- matched pair (1)
- meningioma (1)
- molecular medicine (1)
- myocardial perfusion imaging (1)
- nephrology (1)
- nephrotoxicity (1)
- neuroblastoma (1)
- neuroendocrine neoplasia (1)
- neuroendocrine neoplasms (NEN) (1)
- neuroendocrine tumors (NET) (1)
- nonhuman primates (1)
- overall survival (1)
- polymyalgia rheumatica (1)
- precision medicine (1)
- prediction (1)
- prostate-specific antigen (1)
- quantification (1)
- radiotracer kinetics (1)
- rats (1)
- renal (1)
- renal failure (1)
- renal function (1)
- renal imaging (1)
- reporting and data systems (1)
- single photon emission computed tomography: sympathetic nerve (1)
- solid tumors (1)
- split renal function (1)
- staging (1)
- standardization (1)
- standardized reporting (1)
- standardized reporting system (1)
- statin (1)
- stem cells (1)
- stem-cell research (1)
- stroke (1)
- unilateral ureteral obstruction (1)
- urology (1)
- vasculature (1)
- vasculitis (1)
- vestibular schwannoma (1)
Institute
- Klinik und Poliklinik für Nuklearmedizin (42)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (6)
- Medizinische Klinik und Poliklinik II (6)
- Medizinische Klinik und Poliklinik I (4)
- Urologische Klinik und Poliklinik (4)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (2)
- Pathologisches Institut (2)
- Comprehensive Cancer Center Mainfranken (1)
- Institut für Pharmazie und Lebensmittelchemie (1)
- Neurochirurgische Klinik und Poliklinik (1)
Sonstige beteiligte Institutionen
EU-Project number / Contract (GA) number
- 701983 (20)
Purpose of Review
Statins are routinely applied in patients with coronary artery disease, as they allow significantly to reduce blood cholesterol levels. Although those drugs are endorsed by current guidelines and prescribed routinely, a substantial portion of patients are still statin-intolerant and image-piloted strategies may then be helpful to identify patients that need further intensified treatment, e.g., to initiate treatment with proprotein convertase subtilisin / kexin type 9 inhibitors (PCSK9i). In addition, it has also been advocated that statins exhibit nonlipid, cardio-protective effects including improved cardiac nerve integrity, blood flow, and anti-inflammatory effects in congestive heart failure (HF) patients.
Recent Findings
In subjects after myocardial infarction treated with statins, \(^{123}\)I-metaiodobenzylguanidine (MIBG) scintigraphy has already revealed enhanced cardiac nerve function relative to patients without statins. In addition, all of those aforementioned statin-targeted pathways in HF can be visualized and monitored using dedicated cardiac radiotracers, e.g., \(^{123}\)I-MIBG or \(^{18}\)F-AF78 (for cardiac nerve function), \(^{18}\)F-flurpiridaz (to determine coronary flow) or \(^{68}\)Ga-PentixaFor (to detect inflammation).
Summary
Statins exhibit various cardio-beneficial effects, including improvement of cardiac nerve function, blood flow, and reduction of inflammation, which can all be imaged using dedicated nuclear cardiac radiotracers. This may allow for in vivo monitoring of statin-induced cardioprotection beyond lipid profiling in HF patients.
Background
Labelled with lutetium-177, the urea-based small molecules PSMA I&T and PSMA-617 are the two agents most frequently used for radioligand therapy (RLT) in patients with advanced metastatic castration-resistant and prostate-specific membrane antigen (PSMA) expressing prostate cancer (mCRPC). In this matched-pair analysis, we aimed to compare the toxicity and efficacy of both agents for PSMA-directed RLT.
Materials and methods
A total of 110 mCRPC patients from two centres were accrued, 55 individuals treated with [\(^{177}\)Lu]Lu-PSMA I&T, and a matched cohort of 55 patients treated with [\(^{177}\)Lu]Lu-PSMA-617. Matching criteria included age at the first cycle, Gleason score, prostate-specific antigen (PSA) values, and previous taxane-based chemotherapy. Using common terminology criteria for adverse events (CTCAE v. 5.0), toxicity profiles were investigated (including bone marrow and renal toxicity). Overall survival (OS) between both groups was compared.
Results
Toxicity assessment revealed grade III anaemia in a single patient (1.8%) for [\(^{177}\)Lu]Lu-PSMA I&T and five (9.1%) for [\(^{177}\)Lu]Lu-PSMA-617. In addition, one (1.9%) grade III thrombopenia for [\(^{177}\)Lu]Lu-PSMA-617 was recorded. Apart from that, no other grade III/IV toxicities were present. A median OS of 12 months for patients treated with [\(^{177}\)Lu]Lu-PSMA I&T did not differ significantly when compared to patients treated with [\(^{177}\)Lu]Lu-PSMA-617 (median OS, 13 months; P = 0.89).
Conclusion
In this matched-pair analysis of patients receiving one of the two agents most frequently applied for PSMA RLT, the rate of clinically relevant toxicities was low for both compounds. In addition, no relevant differences for OS were observed.