Refine
Has Fulltext
- yes (18)
Is part of the Bibliography
- yes (18)
Document Type
- Journal article (18)
Language
- English (18)
Keywords
- melanoma (5)
- BRAF (2)
- PD-1 (2)
- angiogenesis (2)
- immunohistochemistry (2)
- machine learning (2)
- B7-H1 Antigen (1)
- BARF-mutated melanoma (1)
- BRAF mutation (1)
- COVID-19 (1)
Institute
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (18)
- Urologische Klinik und Poliklinik (4)
- Medizinische Klinik und Poliklinik II (3)
- Pathologisches Institut (3)
- Theodor-Boveri-Institut für Biowissenschaften (3)
- Center for Computational and Theoretical Biology (2)
- Medizinische Klinik und Poliklinik I (2)
- Comprehensive Cancer Center Mainfranken (1)
- Institut für Pharmazie und Lebensmittelchemie (1)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (1)
Sonstige beteiligte Institutionen
Programmed cell death‐ligand 1 (PD‐L1) is an important predictive biomarker. The detection of PD‐L1 can be crucial for patients with advanced cancer where the use of immunotherapy is considered. Here, we demonstrate the use of immuno‐SERS microscopy (iSERS) for localizing PD‐L1 on single cancer SkBr‐3 cells. A central advantage of iSERS is that the disturbing autofluorescence from cells and tissues can be efficiently minimized by red to near‐infrared laser excitation. In this study we employed Au/Au core/satellite nanoparticles as SERS nanotags because of their remarkable signal brightness and colloidal stability upon red laser excitation. False‐color iSERS images of the positive and negative controls clearly reveal the specific localization of PD‐L1 with SERS nanotag‐labeled antibodies.