Refine
Has Fulltext
- yes (31) (remove)
Is part of the Bibliography
- yes (31)
Year of publication
Document Type
- Journal article (31) (remove)
Language
- English (31)
Keywords
- Medizin (3)
- liraglutide (3)
- obesity (3)
- Fn14 (2)
- MIZ1 (2)
- MYC (2)
- NFκB (2)
- Roux-en-Y gastric bypass surgery (2)
- TWEAK (2)
- agonistic antibodies (2)
Institute
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (26)
- Theodor-Boveri-Institut für Biowissenschaften (7)
- Frauenklinik und Poliklinik (5)
- Institut für Anatomie und Zellbiologie (4)
- Medizinische Klinik und Poliklinik I (4)
- Pathologisches Institut (4)
- Medizinische Klinik und Poliklinik II (3)
- Comprehensive Cancer Center Mainfranken (2)
- Institut für Klinische Epidemiologie und Biometrie (2)
- Institut für Molekulare Infektionsbiologie (2)
Sonstige beteiligte Institutionen
TNF-like weak inducer of apoptosis (TWEAK) and inhibition of protein synthesis with cycloheximide (CHX) sensitize for poly(I:C)-induced cell death. Notably, although CHX preferentially enhanced poly(I:C)-induced apoptosis, TWEAK enhanced primarily poly(I:C)-induced necroptosis. Both sensitizers of poly(I:C)-induced cell death, however, showed no major effect on proinflammatory poly(I:C) signaling. Analysis of a panel of HeLa-RIPK3 variants lacking TRADD, RIPK1, FADD, or caspase-8 expression revealed furthermore similarities and differences in the way how poly(I:C)/TWEAK, TNF, and TRAIL utilize these molecules for signaling. RIPK1 turned out to be essential for poly(I:C)/TWEAK-induced caspase-8-mediated apoptosis but was dispensable for this response in TNF and TRAIL signaling. TRADD-RIPK1-double deficiency differentially affected poly(I:C)-triggered gene induction but abrogated gene induction by TNF completely. FADD deficiency abrogated TRAIL- but not TNF- and poly(I:C)-induced necroptosis, whereas TRADD elicited protective activity against all three death inducers. A general protective activity against poly(I:C)-, TRAIL-, and TNF-induced cell death was also observed in FLIPL and FLIPS transfectrants.