Refine
Has Fulltext
- yes (42)
Is part of the Bibliography
- yes (42)
Year of publication
Document Type
- Journal article (38)
- Doctoral Thesis (2)
- Other (2)
Keywords
- CVID (2)
- Inzisionalhernie (2)
- Robotik (2)
- Umbilikalhernie (2)
- disease (2)
- incisional hernia (2)
- linea alba (2)
- minimally invasive (2)
- periodontitis (2)
- primär ventrale Hernie (2)
Author
- Baur, Johannes (12)
- Wiegering, Armin (9)
- Dietz, Ulrich A. (8)
- Dörfer, Jörg (8)
- Eisner, Lukas (8)
- Keller, Nicola (8)
- Ramser, Michaela (8)
- Germer, Christoph-Thomas (4)
- Steger, Ulrich (4)
- Vogel, Ulrich (4)
- Elias, Johannes (3)
- Forster, Johannes (3)
- Frosch, Matthias (3)
- Garcia-Ureña, Miguel (3)
- Klein, Ingo (3)
- Kudsi, O. Yusef (3)
- Liese, Johannes G. (3)
- Maksimovic, Sladjana (3)
- Muysoms, Filip (3)
- Nöth, Ulrich (3)
- Rudert, Maximilian (3)
- Wahn, Ulrich (3)
- Fasshauer, Maria (2)
- Fassnacht, Martin (2)
- Glatz, Johannes (2)
- Harks, Inga (2)
- Hauck, Fabian (2)
- Heuschmann, Peter U. (2)
- Hewig, Johannes (2)
- Karger, Gabriele (2)
- Keil, Thomas (2)
- Kiwus, Ulrich (2)
- Knoglinger, Ernst (2)
- Kukleta, Jan F. (2)
- Kunzmann, Volker (2)
- Lau, Susanne (2)
- Meng, Karin (2)
- Mussel, Patrick (2)
- Niehues, Tim (2)
- Otto, Christoph (2)
- Rackwitz, Lars (2)
- Reichert, Johannes C. (2)
- Schlagenhauf, Ulrich (2)
- Schuster, Antje (2)
- Wagener, Johannes (2)
- Warnatz, Klaus (2)
- Westphal, Ronja (2)
- Wittke, Kirsten (2)
- Zepp, Fred (2)
- Abhari, Behnaz Ahangarian (1)
- Aktas, Orhan (1)
- Albert, Michael H. (1)
- Albus, Christian (1)
- Allen, John J. B. (1)
- Altmann, Bettina (1)
- Amin, Najaf (1)
- Ankermann, Tobias (1)
- Atschekzei, Faranaz (1)
- Aulchenko, Yurii S. (1)
- Avila, Anne (1)
- Avots, Andris (1)
- Bader, Peter (1)
- Bakhtiar, Shahrzad (1)
- Baldus, Claudia D. (1)
- Bassermann, Florian (1)
- Bauer, Carl-Peter (1)
- Bauer, Carl‐Peter (1)
- Baulmann, Johannes (1)
- Baumann, Ulrich (1)
- Baumann, Ulrich H. (1)
- Behrends, Uta (1)
- Beider, Renata (1)
- Bellenguez, Céline (1)
- Belohradsky, Bernd H. (1)
- Benzer, Werner (1)
- Berdel, Wolfgang E. (1)
- Bergen, Arthur A. B. (1)
- Bergh, Florian Then (1)
- Bergmann, Karl E. (1)
- Bergmann, Renate L. (1)
- Bernbeck, Benedikt (1)
- Bernuth, Horst von (1)
- Berthele, Achim (1)
- Biegner, Anika-Kerstin (1)
- Bielack, Stefan (1)
- Bismarck, Philipp von (1)
- Bjarnason-Wehrens, Birna (1)
- Bode, Sebastian (1)
- Boehm, Hartmut (1)
- Boesecke, Christoph (1)
- Boettcher, Tobias (1)
- Bornhäuser, Martin (1)
- Borrow, Ray (1)
- Borte, Michael (1)
- Borte, Stephan (1)
- Boztug, Kaan (1)
- Brettschneider, Johannes (1)
- Brummel, Bastian (1)
- Brunner, Andrä (1)
- Brzoska, Patrick (1)
- Brümmendorf, Tim H. (1)
- Buhr-Schinner, Heike (1)
- Burchert, Andreas (1)
- Burkhard‐Meier, Ulrike (1)
- Bönner, Gerd (1)
- Büntemeyer, Tjark-Ole (1)
- Büttner, Thomas (1)
- Carbonaro, Francis (1)
- Carlo, Gustavo (1)
- Charrier, Albrecht (1)
- Classen, Carl F. (1)
- Claus, Heike (1)
- Cordes, Carsten (1)
- Corteville, Carolin (1)
- Crysandt, Martina (1)
- Czudowska, Monika A. (1)
- Damm, Oliver (1)
- Despriet, Dominiek D. G. (1)
- Deutschbein, Timo (1)
- Deutz, Peter (1)
- Di Pietro, Antonio (1)
- Dichtl, Karl (1)
- Dietz, Ulrich (1)
- Dietzel, Joanna (1)
- Dilloo, Dagmar (1)
- Dirks, Johannes (1)
- Dischinger, Ulrich (1)
- Dramburg, Stephanie (1)
- Dörr, Gesine (1)
- Dückers, Gregor (1)
- Eckardt, Jan-Niklas (1)
- Eckardt, Kai‐Uwe (1)
- Eckhardt, Frithjof (1)
- Eden, Lars (1)
- Ehl, Stephan R. (1)
- Ehmke, Benjamin (1)
- Ehninger, Gerhard (1)
- Eichinger, Anna (1)
- Eichler, Sarah (1)
- Eichner, Martin (1)
- Eickholz, Peter (1)
- Eigenthaler, Martin (1)
- Eilts, Janna (1)
- Einsele, Hermann (1)
- El-Helou, Sabine M. (1)
- Endres, Matthias (1)
- Engel, Katharina (1)
- Ernst, Diana (1)
- Ettrich, Barbara (1)
- Exner, Anne-Kathrin (1)
- Eyrich, Matthias (1)
- Faiss, Jürgen H. (1)
- Faller, Hermann (1)
- Fernández-Sáiz, Vanesa (1)
- Fickl, Stefan (1)
- Filser, Paula (1)
- Findlow, Jamie (1)
- Fischer, Felix (1)
- Foell, Dirk (1)
- Forchert, Leandra (1)
- Foster, Paul J. (1)
- Frickhofen, Norbert (1)
- Fromm, Bernd (1)
- Fulda, Simone (1)
- Geberzahn, Linda (1)
- Geis, Christian (1)
- Gerschmann, Stev (1)
- Ghosh, Sujal (1)
- Gielen, Stephan (1)
- Gierlich, Philipp (1)
- Gilbert, Fabian (1)
- Girschick, Hermann (1)
- Glennie, Anne (1)
- Gloeckner, Christian Johannes (1)
- Glunz, Amelie (1)
- Goettler, David (1)
- Gohlke, Helmut (1)
- Grabenhenrich, Linus (1)
- Grabenhenrich, Linus B. (1)
- Graf, Dagmar (1)
- Graf, Norbert (1)
- Gramer, Eugen (1)
- Gravemeier, Martina (1)
- Greil, Johann (1)
- Greiner, Wolfgang (1)
- Grigoleit, Götz Ulrich (1)
- Grilli, Maurizio (1)
- Grimbacher, Bodo (1)
- Groß-Wieltsch, Ute (1)
- Guthke, Kersten (1)
- Gysan, Detlef (1)
- Götz, Ralph (1)
- Haase, Gabriele (1)
- Habermehl, Pirmin (1)
- Haenicke, Henriette (1)
- Haerlein, Miriam (1)
- Haeusler, Karl Georg (1)
- Hahmann, Harry (1)
- Hamann, Gerhard F. (1)
- Hammond, Christopher J. (1)
- Handgretinger, Rupert (1)
- Hanitsch, Leif (1)
- Hanitsch, Leif G. (1)
- Hankir, Mohamed (1)
- Hartung, Hans P. (1)
- Hasinger, Julia (1)
- Haubitz, Imme (1)
- Hauenherm, Anja (1)
- Hausmann, Johannes (1)
- Hayrettin, Christoph A. (1)
- Hedrich, Christian M. (1)
- Heeg, Maximilian (1)
- Heine, Sabine (1)
- Hellige, Antje (1)
- Hellwig, Kerstin (1)
- Hemmer, Bernhard (1)
- Henes, Jörg (1)
- Herbst, Regina (1)
- Herrmann, Friedrich (1)
- Herrmann-Lingen, Christoph (1)
- Hewitt, Alex W. (1)
- Heß, Ursula (1)
- Hochhaus, Andreas (1)
- Hoffman, Ute (1)
- Hoffmann, Frank (1)
- Hofman, Albert (1)
- Hofstadt-van Oy, Ulrich (1)
- Holzer, Ursula (1)
- Horneff, Gerd (1)
- Horns, Heidi (1)
- Hosseini, S. Mohsen (1)
- Huppertz, Hans-Iko (1)
- Hys, Pirro G. (1)
- Hänel, Mathias (1)
- Härtel, Ursula (1)
- Hönig, Manfred (1)
- Hülsmann, Brigitte (1)
- Icke, Katja (1)
- Ikram, M. Kamran (1)
- Jablonka, Alexandra (1)
- Jacobs, Laura (1)
- Jakob, Franz (1)
- Jakoby, Donate (1)
- Jansonius, Nomdo M. (1)
- Janssen, Sarah F. (1)
- Jarius, Sven (1)
- Jensen, Katrin (1)
- Jockel-Schneider, Yvonne (1)
- Jost, Philipp J. (1)
- Kaiser, Ulrich (1)
- Kaiser-Labusch, Petra (1)
- Kamitz, Dirk (1)
- Kamugisha, Erasmus (1)
- Kaner, Doğan (1)
- Kanz, Lothar (1)
- Karoff, Marthin (1)
- Kataraihya, Johannes B. (1)
- Kaufmann, Martin (1)
- Keijzers, Wendy C. (1)
- Keller, Ulrich (1)
- Kellner, Nils (1)
- Kern, Peter (1)
- Keupp, Anne (1)
- Kickuth, Ralph (1)
- Kim, Ti‐Sun (1)
- Kindle, Gerhard (1)
- Kirchhof, Paulus (1)
- Klapper, Wolfram (1)
- Klasen, Jessica (1)
- Klaus, Schwarz (1)
- Klaver, Caroline C. W. (1)
- Klein, Ariane (1)
- Klein, Christoph (1)
- Klein-Hessling, Stefan (1)
- Kleinschnitz, Christoph (1)
- Kleiter, Ingo (1)
- Klemann, Christian (1)
- Klock, Gerd (1)
- Knuf, Markus (1)
- Kobbe, Robin (1)
- Koch, Raphael (1)
- Kocher, Thomas (1)
- Kochmann, Thomas F. (1)
- Kolb-Mäurer, Annette (1)
- Kramer, Michael (1)
- Kramer, Rogier (1)
- Kramm, Christof (1)
- Kranz, Julius (1)
- Krause, Stefan W. (1)
- Krempl, Christine (1)
- Kroiss, Matthias (1)
- Kroschinsky, Frank (1)
- Krusch, Christian-Wolfgang (1)
- Krämer, Alwin (1)
- Krämer, Michael (1)
- Krüger, Hagen (1)
- Krüger, Renate (1)
- Kuempfel, Tania (1)
- Kullmann, Silke (1)
- Kulozik, Andreas E. (1)
- Kunze, Claudia (1)
- Kurutz, Julia (1)
- Königsrainer, Malina (1)
- Kühnle, Ingrid (1)
- Lamers, Beate (1)
- Langel, Stefan (1)
- Langemeyer, Vanessa (1)
- Langheim, Eike (1)
- Lara-Villacanas, Eusebia (1)
- Lassy, Lisa (1)
- Lauda, Florian (1)
- Laufs, Ulrich (1)
- Laws, Hans-Juergen (1)
- Lee, Jae-Yun (1)
- Lehmann, Lisa (1)
- Lehmberg, Kai (1)
- Lemij, Hans G. (1)
- Lex, Veronika (1)
- Liebetrau, Martin (1)
- Liese, Johannes (1)
- Linker, Ralf A. (1)
- Loeb, Stefan (1)
- Loewecke, Felicia (1)
- Lorenz, Katrin (1)
- Lupinek, Christian (1)
- Lyamuya, Eligius F. (1)
- Maccari, Maria E. (1)
- Macgregor, Stuart (1)
- Mackey, David A. (1)
- Maier, Sebastian (1)
- Mann, Johannes (1)
- Marcu, Ana (1)
- Mardin, Christian Y. (1)
- Martin, Diana R. (1)
- Marziniak, Martin (1)
- Masjosthusmann, Katja (1)
- Matern, Johannes (1)
- Matricardi, Paolo Maria (1)
- Max, Regina (1)
- Mayer, Jiří (1)
- McGuffin, Peter (1)
- Megerle, Felix (1)
- Melms, Arthur (1)
- Metz, Imke (1)
- Metz, Matthes (1)
- Metzendorf, Maria-Inti (1)
- Metzler, Markus (1)
- Meyer, Oliver (1)
- Meyle, Jörg (1)
- Middeke, Jan Moritz (1)
- Mielke, Gudrun (1)
- Mitchell, Paul (1)
- Mohr, Michael (1)
- Montgomery, Grant W. (1)
- Morbach, Henner (1)
- Moremi, Nyambura (1)
- Morper, Lorenz (1)
- Mshana, Stephen E. (1)
- Muhammad, Khalid (1)
- Murti, Krisna (1)
- Musekamp, Gunda (1)
- Müglich, Carmen (1)
- Müller, Anna H. (1)
- Müller, Christiane (1)
- Müller, Ingo (1)
- Müller, Nora (1)
- Müller, Rainer (1)
- Müller, Thomas G. (1)
- Müller-Tidow, Carsten (1)
- Müllges, Wolfgang (1)
- Münch, Christoph (1)
- Münstermann, Esther (1)
- Nabavi, Darius G. (1)
- Naumann, Ralph (1)
- Naumann-Bartsch, Nora (1)
- Nawroth, Peter (1)
- Nebel, Roland (1)
- Neubauer, Andreas (1)
- Neubert, Jennifer (1)
- Neuhaus, Oliver (1)
- Niebauer, Josef (1)
- Niehaus, Sabine (1)
- Noppeney, Richard (1)
- Olma, Manuel C. (1)
- Oommen, Prasad T. (1)
- Oostra, Ben A. (1)
- Ormanns, Steffen (1)
- Osinsky, Roman (1)
- Oster, Philipp (1)
- Pachlopnik‐Schmid, Jana (1)
- Panetta, Valentina (1)
- Panzer, Sabine (1)
- Pasutto, Francesca (1)
- Paterson, Andrew D. (1)
- Paul, Friedemann (1)
- Peitz, Joachim (1)
- Pellkofer, Hannah (1)
- Perna, Serena (1)
- Peschel, Christian (1)
- Petersmann, Astrid (1)
- Pfeiffer‐Kascha, Dorothea (1)
- Pfeilschifter, Waltraud (1)
- Pfreundschuh, Michael (1)
- Platzbecker, Uwe (1)
- Posa, Daniela (1)
- Potapova, Ekaterina (1)
- Prager, Patrick (1)
- Predel, Hans-Georg (1)
- Preßler, Axel (1)
- Prifert, Christiane (1)
- Pullig, Oliver (1)
- Pusch, Tobias (1)
- Quent, Verena M. C. (1)
- Quinkler, Marcus (1)
- Rachor, Johannes (1)
- Rack-Hoch, Anita (1)
- Ramdas, Wishal D. (1)
- Rathakrishnan, Abirami (1)
- Rauch, Bernhard (1)
- Razum, Oliver (1)
- Reich, Andreas (1)
- Reichert, Johannes (1)
- Reis, Andre (1)
- Reiss, Nils (1)
- Renz, Tim (1)
- Reppenhagen, Stephan (1)
- Resch‐Marat, Yvonne (1)
- Reuss, Reinhard (1)
- Rieber, Nikolaus (1)
- Riedmiller, Hubertus (1)
- Riegel, Johannes (1)
- Ringelstein, Marius (1)
- Ritter, Christian O. (1)
- Ritterbusch, Henrike (1)
- Rivadeneira, Fernando (1)
- Rockstroh, Jürgen K. (1)
- Rodrigues, Johannes (1)
- Roesler, Joachim (1)
- Rohrbach, Alexander (1)
- Rommer, Paulus S. (1)
- Rose, Markus A. (1)
- Rosenwald, Andreas (1)
- Roth, Franz (1)
- Rudelius, Martina (1)
- Ruprecht, Klemens (1)
- Rusch, Stephan (1)
- Rácil, Zdenek (1)
- Röllig, Christoph (1)
- Rösen-Wolff, Angela (1)
- Röther, Joachim (1)
- Salzwedel, Annett (1)
- Sauer, Markus (1)
- Sauer, Sascha (1)
- Saure, Daniel (1)
- Schaberg, Tom (1)
- Schaich, Markus (1)
- Schauer, Uwe (1)
- Scheibenbogen, Carmen M. (1)
- Scheible, Raphael (1)
- Schetelig, Johannes (1)
- Schippling, Sven (1)
- Schlegel, Paul G. (1)
- Schliemann, Christoph (1)
- Schmalzing, Marc T. (1)
- Schmalzl, Jonas (1)
- Schmid, Jean-Paul (1)
- Schmidt, Nadine (1)
- Schmidt, Reinhold E. (1)
- Schmitt, Corinna (1)
- Schneider, Dominik T. (1)
- Scholl, Sebastian (1)
- Schouls, Leo M. (1)
- Schreiber, Stefan (1)
- Schubert, Ralf (1)
- Schubmann, Rainer (1)
- Schultz, Konrad (1)
- Schulz, Ansgar (1)
- Schulz, Claudia (1)
- Schurig, Johannes (1)
- Schwaab, Bernhard (1)
- Schwaneck, Eva C. (1)
- Schwarze-Zander, Carolynne (1)
- Schwehm, Markus (1)
- Schweigerer, Lothar (1)
- Schäfer-Eckart, Kerstin (1)
- Schönberger, Stefan (1)
- Schürmann, Gesine (1)
- Schütt, Morten (1)
- Seekatz, Bettina (1)
- Sennholz, Hanno (1)
- Serfling, Edgar (1)
- Serve, Hubert (1)
- Seybold, Ulrich (1)
- Seyfried, Florian Johannes David (1)
- Shai, Sonu (1)
- Sieb, Jörn P. (1)
- Skoda, Eva-Maria (1)
- Slawska, Jolanta (1)
- Sobik, Bettina (1)
- Soetedjo, Veronika (1)
- Sogkas, Georgios (1)
- Sollinger, Franz M. (1)
- Specker, Christof (1)
- Speckmann, Carsten (1)
- Spitzweg, Christine (1)
- Stangel, Martin (1)
- Stasik, Sebastian (1)
- Steffen, Björn (1)
- Steinert, Andre F. (1)
- Steinmann, Sandra (1)
- Steube, Diethard (1)
- Stiefel, Martina (1)
- Streibelt, Marco (1)
- Streng, Andrea (1)
- Struchalin, Maksim (1)
- Stölzel, Friedrich (1)
- Stüttgen, Martin (1)
- Stüttgen, Michaela (1)
- Suerbaum, Sebastian (1)
- Tappe, Dennis (1)
- Targosz, Bianca-Sabrina (1)
- Technau, Antje (1)
- Tenbrock, Klaus (1)
- Terpitz, Ulrich (1)
- Teufel, Martin (1)
- Thiede, Christian (1)
- Thomalla, Götz (1)
- Tietsch, Nadine (1)
- Tony, Hans-Peter (1)
- Topouzis, Fotis (1)
- Trebst, Corinna (1)
- Tremmel, Angelika (1)
- Trinks, Nora (1)
- Trümper, Lorenz (1)
- Tschanz, Hansueli (1)
- Tuan, Rocky S. (1)
- Tumani, Hayrettin (1)
- Turrà, David (1)
- Tütüncü, Serdar (1)
- Ueffing, Marius (1)
- Uitterlinden, Andre G. (1)
- Ulrich, Jakob Johannes (1)
- Ulrich, Johannes (1)
- Ulrich, Kristina (1)
- Ulrich, Natalie (1)
- Ulrich, Nathalie (1)
- Valenta, Rudolf (1)
- Veauthier, Christian (1)
- Veltkamp, Roland (1)
- Viemann, Dorothee (1)
- Vingerling, Johannes R. (1)
- Vinnemeier-Laubenthal, Elisabeth (1)
- Viswanathan, Ananth C. (1)
- Vogel, Heiner (1)
- Vrtala, Susanne (1)
- Völler, Heinz (1)
- Wagner, Johanna (1)
- Wagner, Norbert (1)
- Walles, Heike (1)
- Walles, Thorsten (1)
- Wandinger, Klaus P. (1)
- Wang, Jie Jin (1)
- Wasmuth, Jan-Christian (1)
- Wehr, Claudia (1)
- Weisschuh, Nicole (1)
- Weisser, Christoph (1)
- Weiß, Michael (1)
- Weißbrich, Benedikt (1)
- Welge-Lüssen, Ulrich (1)
- Westkemper, Marco (1)
- Wildemann, Brigitte (1)
- Wilke, Christian (1)
- Willemse-Assink, Jacqueline J. M. (1)
- Winkelmann, Alexander (1)
- Wismer, Rhoda (1)
- Wittkowski, Helmut (1)
- Wolfs, Roger C. W. (1)
- Wong, Tien Y. (1)
- Wunder, Christian (1)
- Wutzler, Peter (1)
- Wölfl, Matthias (1)
- Wölke, Sandra (1)
- Young, Terri L. (1)
- Zenkel, Matthias (1)
- Zentner, Christian (1)
- Zettl, Uwe K (1)
- Zeuner, Rainald (1)
- Zielen, Stefan (1)
- Ziemann, Ulf (1)
- Zimmermann, Antje (1)
- de Jong, Paulus T. V. M. (1)
- ten Brink, Jacoline B. (1)
- van Duijn, Cornelia M. (1)
- van Koolwijk, Leonieke M. E. (1)
- van de Pol, Ingrid (1)
- van der Ende, Arie (1)
- von Bernuth, Horst (1)
- von Rottkay, Eberhard (1)
- von Schacky, Clemens (1)
- Ülzen, Anett (1)
Institute
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (12)
- Institut für Hygiene und Mikrobiologie (7)
- Kinderklinik und Poliklinik (6)
- Institut für Klinische Epidemiologie und Biometrie (4)
- Medizinische Klinik und Poliklinik II (4)
- Lehrstuhl für Orthopädie (3)
- Abteilung für Molekulare Innere Medizin (in der Medizinischen Klinik und Poliklinik II) (2)
- Abteilung für Parodontologie (in der Poliklinik für Zahnerhaltung und Parodontologie) (2)
- Institut für Psychologie (2)
- Institut für Psychotherapie und Medizinische Psychologie (2)
Hanitsch, Leif ; Baumann, Ulrich ; Boztug, Kaan ; Burkhard‐Meier, Ulrike ; Fasshauer, Maria ; Habermehl, Pirmin ; Hauck, Fabian ; Klock, Gerd ; Liese, Johannes ; Meyer, Oliver ; Müller, Rainer ; Pachlopnik‐Schmid, Jana ; Pfeiffer‐Kascha, Dorothea ; Warnatz, Klaus ; Wehr, Claudia ; Wittke, Kirsten ; Niehues, Tim ; von Bernuth, Horst
This evidence‐based clinical guideline provides consensus‐recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. Recommendations were based on results of a systematic literature search, data extraction, and evaluation of methodology and study quality in combination with the clinical expertise of the respective representatives. Consensus‐based recommendations were determined via nominal group technique. PADs are the largest clinically relevant group of primary immunodeficiencies. Most patients with PADs present with increased susceptibility to infections, however immune dysregulation, autoimmunity, and cancer affect a significant number of patients and may precede infections. This guideline therefore covers interdisciplinary clinical and therapeutic aspects of infectious (e.g., antibiotic prophylaxis, management of bronchiectasis) and non‐infectious manifestations (e.g., management of granulomatous disease, immune cytopenia). PADs are grouped into disease entities with definitive, probable, possible, or unlikely benefit of IgG‐replacement therapy. Summary and consensus‐recommendations are provided for treatment indication, dosing, routes of administration, and adverse events of IgG‐replacement therapy. Special aspects of concomitant impaired T‐cell function are highlighted as well as clinical data on selected monogenetic inborn errors of immunity formerly classified into PADs (APDS, CTLA‐4‐, and LRBA‐deficiency).
Baur, Johannes ; Otto, Christoph ; Steger, Ulrich ; Klein-Hessling, Stefan ; Muhammad, Khalid ; Pusch, Tobias ; Murti, Krisna ; Wismer, Rhoda ; Germer, Christoph-Thomas ; Klein, Ingo ; Müller, Nora ; Serfling, Edgar ; Avots, Andris
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor-mediated activation of lymphocytes. Downstream targets of CN in lymphocytes are the nuclear factors of activated T cells (NFATs). We show here that the activity of NFATc1, the most prominent NFAT factor in activated lymphocytes supports the acute rejection of heterotopic heart allografts. While ablation of NFATc1 in T cells prevented graft rejection, ectopic expression of inducible NFATc1/αA isoform led to rejection of heart allografts in recipient mice. Acceptance of transplanted hearts in mice bearing NFATc1-deficient T cells was accompanied by a reduction in number and cytotoxicity of graft infiltrating cells. In CD8\(^+\) T cells, NFATc1 controls numerous intracellular signaling pathways that lead to the metabolic switch to aerobic glycolysis and the expression of numerous lymphokines, chemokines, and their receptors, including Cxcr3 that supports the rejection of allogeneic heart transplants. These findings favors NFATc1 as a molecular target for the development of new strategies to control the cytotoxicity of T cells upon organ transplantation.