Refine
Has Fulltext
- yes (16) (remove)
Is part of the Bibliography
- yes (16)
Document Type
- Journal article (16) (remove)
Language
- English (16)
Keywords
- foraging (2)
- nutrition (2)
- ANTARES telescope (1)
- Alzheimer's disease (1)
- Antioxidants (1)
- Arabidopsis (1)
- Brain diseases (1)
- C virus (1)
- Dionaea muscipula (1)
- Epichloë (1)
- Epichloë spp. (1)
- Galactic Ridge (1)
- Glutathione (1)
- Lolium perenne (1)
- Metabolomics (1)
- Nanoparticles (1)
- P-glycoprotein (1)
- PER (1)
- Premna (1)
- Serine proteases (1)
- Silver (1)
- Tanzania (1)
- Uganda (1)
- Venusfliegenfalle (1)
- WIMP (1)
- Wnt signalling (1)
- adult bees (1)
- alkaloids (1)
- bee decline (1)
- betaglycan (1)
- bioinformatics (1)
- biomarker (1)
- blood (1)
- cool-season grass species (1)
- coreceptor (1)
- cytotoxic (1)
- dark matter (1)
- dark matter detectors (1)
- dark matter experiments (1)
- disease (1)
- endophyte (1)
- expression (1)
- gene (1)
- gene expression (1)
- generation (1)
- glycoprotein (1)
- grass endophytes (1)
- growth factor beta (1)
- health care workers (1)
- hepatitis B virus (1)
- hepatitis C virus (1)
- horses (1)
- human-immunodeficiency-virus (1)
- in vivo (1)
- indirect detection (1)
- infection rates (1)
- jasmonic acid biosynthesis (1)
- ligand binding (1)
- lignan (1)
- livestock (1)
- lung-cancer (1)
- maintain immune homeostasis (1)
- malignant melanoma (1)
- mesenchymal stem cells (1)
- metabolomic (1)
- miRNA (1)
- microarray (1)
- microna profiles (1)
- multiple sclerosis (1)
- mutagenesis (1)
- neutralino (1)
- neutralizing antibody (1)
- neutrino astronomy (1)
- neutrino detectors (1)
- neutrino emission (1)
- neutrino telescope (1)
- nutrients (1)
- osteoporosis (1)
- perennial ryegrass (1)
- peripheral blood (1)
- phage display (1)
- pharmacophore map (1)
- plant-insect interactions (1)
- point-of-care test (1)
- pollen (1)
- pollen quality (1)
- polymerization (1)
- proteins (1)
- receptor type III (1)
- regulatory T cells (1)
- resource use (1)
- resources (1)
- sclerostin (1)
- seroprevalence (1)
- serum (1)
- signal transduction (1)
- signature (1)
- skin (1)
- sun (1)
- superfamily (1)
- syphilis (1)
- tolerance (1)
- toxicity (1)
- transplant (1)
- transporters (1)
- vaccine (1)
Institute
- Julius-von-Sachs-Institut für Biowissenschaften (8)
- Theodor-Boveri-Institut für Biowissenschaften (4)
- Institut für Theoretische Physik und Astrophysik (3)
- Frauenklinik und Poliklinik (1)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (1)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (1)
- Medizinische Fakultät (1)
EU-Project number / Contract (GA) number
- 250194 (2)
- HEALTHF2- 2008-201099 (1)
A highly significant excess of high-energy astrophysical neutrinos has been reported by the IceCube Collaboration. Some features of the energy and declination distributions of IceCube events hint at a North/South asymmetry of the neutrino flux. This could be due to the presence of the bulk of our Galaxy in the Southern hemisphere. The ANTARES neutrino telescope, located in the Mediterranean Sea, has been taking data since 2007. It offers the best sensitivity to muon neutrinos produced by galactic cosmic ray interactions in this region of the sky. In this letter a search for an extended neutrino flux from the Galactic Ridge region is presented. Different models of neutrino production by cosmic ray propagation are tested. No excess of events is observed and upper limits for different neutrino flux spectral indices Γ are set. For Γ=2.4 the 90% confidence level flux upper limit at 100 TeV for one neutrino flavour corresponds to Φ\(^{1f}_{0}\) (100 TeV) = 2.0 · 10\(^{−17}\) GeV\(^{−1}\) cm\(^{−2}\)s\(^{−1}\)sr\(^{−1}\). Under this assumption, at most two events of the IceCube cosmic candidates can originate from the Galactic Ridge. A simple power-law extrapolation of the Fermi-LAT flux to account for IceCube High Energy Starting Events is excluded at 90% confidence level.
Preventing malnutrition through consuming nutritionally appropriate resources represents a challenge for foraging animals. This is due to often high variation in the nutritional quality of available resources. Foragers consequently need to evaluate different food sources. However, even the same food source can provide a plethora of nutritional and non‐nutritional cues, which could serve for quality assessment. We show that bumblebees, Bombus terrestris , overcome this challenge by relying on lipids as nutritional cue when selecting pollen. The bees ‘prioritised’ lipid perception in learning experiments and avoided lipid consumption in feeding experiments, which supported survival and reproduction. In contrast, survival and reproduction were severely reduced by increased lipid contents. Our study highlights the importance of fat regulation for pollen foraging bumblebees. It also reveals that nutrient perception, nutrient regulation and reproductive fitness can be linked, which represents an effective strategy enabling quick foraging decisions that prevent malnutrition and maximise fitness.
The green synthesis of silver nanoparticles (SNPs) using plant extracts is an eco-friendly method. It is a single step and offers several advantages such as time reducing, cost-effective and environmental non-toxic. Silver nanoparticles are a type of Noble metal nanoparticles and it has tremendous applications in the field of diagnostics, therapeutics, antimicrobial activity, anticancer and neurodegenerative diseases. In the present work, the aqueous extracts of aerial parts of Lampranthus coccineus and Malephora lutea F. Aizoaceae were successfully used for the synthesis of silver nanoparticles. The formation of silver nanoparticles was early detected by a color change from pale yellow to reddish-brown color and was further confirmed by transmission electron microscope (TEM), UV–visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), X-ray diffraction (XRD), and energy-dispersive X-ray diffraction (EDX). The TEM analysis of showed spherical nanoparticles with a mean size between 12.86 nm and 28.19 nm and the UV- visible spectroscopy showed λ\(_{max}\) of 417 nm, which confirms the presence of nanoparticles. The neuroprotective potential of SNPs was evaluated by assessing the antioxidant and cholinesterase inhibitory activity. Metabolomic profiling was performed on methanolic extracts of L. coccineus and M. lutea and resulted in the identification of 12 compounds, then docking was performed to investigate the possible interaction between the identified compounds and human acetylcholinesterase, butyrylcholinesterase, and glutathione transferase receptor, which are associated with the progress of Alzheimer’s disease. Overall our SNPs highlighted its promising potential in terms of anticholinesterase and antioxidant activity as plant-based anti-Alzheimer drug and against oxidative stress.
Adding amino acids to a sucrose diet is not sufficient to support longevity of adult bumble bees
(2020)
Dietary macro-nutrients (i.e., carbohydrates, protein, and fat) are important for bee larval development and, thus, colony health and fitness. To which extent different diets (varying in macro-nutrient composition) affect adult bees and whether they can thrive on nectar as the sole amino acid source has, however, been little investigated. We investigated how diets varying in protein concentration and overall nutrient composition affected consumption, longevity, and breeding behavior of the buff-tailed bumble bee, Bombus terrestris (Hymenoptera: Apidae). Queenless micro-colonies were fed either natural nutrient sources (pollen), nearly pure protein (i.e., the milk protein casein), or sucrose solutions with low and with high essential amino acid content in concentrations as can be found in nectar. We observed micro-colonies for 110 days. We found that longevity was highest for pure pollen and lowest for pure sucrose solution and sucrose solution supplemented with amino acids in concentrations as found in the nectar of several plant species. Adding higher concentrations of amino acids to sucrose solution did only slightly increase longevity compared to sucrose alone. Consequently, sucrose solution with the applied concentrations and proportions of amino acids or other protein sources (e.g., casein) alone did not meet the nutritional needs of healthy adult bumble bees. In fact, longevity was highest and reproduction only successful in micro-colonies fed pollen. These results indicate that, in addition to carbohydrates and protein, adult bumble bees, like larvae, need further nutrients (e.g., lipids and micro-nutrients) for their well-being. An appropriate nutritional composition seemed to be best provided by floral pollen, suggesting that pollen is an essential dietary component not only for larvae but also for adult bees.
Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells (DIRCs) capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1 (PD-1). Purified Abcb5\(^+\) DIRCs suppressed T cell proliferation, evaded immune rejection, homed to recipient immune tissues, and induced Tregs in vivo. In fully major-histocompatibility-complex-mismatched cardiac allotransplantation models, allogeneic DIRCs significantly prolonged allograft survival. Blockade of DIRC-expressed PD-1 reversed the inhibitory effects of DIRCs on T cell activation, inhibited DIRC-dependent Treg induction, and attenuated DIRC-induced prolongation of cardiac allograft survival, indicating that DIRC immunoregulatory function is mediated, at least in part, through PD-1. Our results identify ABCB5\(^+\) DIRCs as a distinct immunoregulatory cell population and suggest promising roles of this expandable cell subset in cellular immunotherapy.
A search for Secluded Dark Matter annihilation in the Sun using 2007-2012 data of the ANTARES neutrino telescope is presented. Three different cases are considered: a) detection of dimuons that result from the decay of the mediator, or neutrino detection from: b) mediator that decays into a dimuon and, in turn, into neutrinos, and c) mediator that decays directly into neutrinos. As no significant excess over background is observed, constraints are derived on the dark matter mass and the lifetime of the mediator.