Refine
Has Fulltext
- yes (23)
Is part of the Bibliography
- yes (23)
Year of publication
Document Type
- Journal article (23)
Language
- English (23)
Keywords
- atherosclerosis (3)
- magnetic resonance imaging (3)
- mouse (3)
- pulse wave velocity (3)
- 4D flow (2)
- CMR (2)
- MRI (2)
- WSS (2)
- ablation (2)
- age (2)
- aortic arch (2)
- inflammation (2)
- myocardial infarction (2)
- radial (2)
- wall shear stress (2)
- 4D flow MRI (1)
- 6-percent hydroxyethyl starch (1)
- AYAs (1)
- Aorta (1)
- Aortic arch (1)
- ApoE\(^{(-/-)}\) (1)
- Atherosclerosis (1)
- BMP antagonist (1)
- BRCA1 (1)
- Central venous-pressure (1)
- Critically-ill patients (1)
- DNA-repair (1)
- DNA-repair genes (1)
- Der p 23 (1)
- EP Procedures (1)
- Elective cesarean-section (1)
- Fontan’s Operation (1)
- GVHD (1)
- Hypertonic saline 7.5-percent (1)
- IgE (1)
- Internet of Things (1)
- Lactated ringers solution (1)
- MR guidance (1)
- Magnetic resonance imaging (1)
- Major abdominal surgery (1)
- Measurement (1)
- Medizin (1)
- Mouse (1)
- Mouse models (1)
- NMR spectroscopy (1)
- OSI (1)
- PWV (1)
- Predict fluid responsiveness (1)
- Puls-pressure variation (1)
- Randomized controlled-trial (1)
- Self-navigation (1)
- Stiffness (1)
- Systole (1)
- TGF-β superfamily (1)
- Time measurement (1)
- age at onset (1)
- aorta (1)
- arterial elasticity (1)
- association (1)
- asthma (1)
- birth cohort (1)
- blood (1)
- body weight (1)
- bone morphogenetic proteins (1)
- breast cancer (1)
- cancer patients (1)
- cardiac ventricles (1)
- catheter tip (1)
- childhood (1)
- comparative genomics (1)
- contact force (1)
- disease (1)
- early-life (1)
- encryption (1)
- extracellular matrix remodeling (1)
- extreme phenotypes (1)
- flow (1)
- flow dynamics (1)
- heart rate (1)
- hereditary breast and ovarian cancer (1)
- house dust mite allergy (1)
- illness (1)
- lesion size (1)
- lipoxygenase (1)
- magnetic resonance (1)
- magnetic resonsance imaging (1)
- mapping (1)
- mapping susceptibility genes (1)
- mice (1)
- microscopy (1)
- model (1)
- models (1)
- molecular neuroscience (1)
- mood disorders (1)
- morality (1)
- mouse models (1)
- next-generation-sequencing (1)
- non-triggered (1)
- observer agreement (1)
- onset (1)
- panel sequencing (1)
- phase contrast (1)
- phase-contrast CMR (1)
- physical functioning (1)
- plaque (1)
- plaque characteristics (1)
- preschool children (1)
- prophylactic lithium (1)
- protein-protein recognition (1)
- pulse-wave velocity (1)
- quantification (1)
- radiofrequency ablation (1)
- reliability (1)
- retrospective (1)
- risk (1)
- safety (1)
- sample (1)
- secure group communication (1)
- self-gating (1)
- self-navigation (1)
- surgical and invasive medical procedures (1)
- symptoms (1)
- temperature (1)
- tissue (1)
- univentricular heart (1)
- vascular surgery (1)
- ventricular tachycardia (1)
- von Willebrand type C domain (1)
- wheeze (1)
- wires (1)
- young children (1)
Institute
- Medizinische Klinik und Poliklinik I (12)
- Physikalisches Institut (10)
- Institut für Experimentelle Biomedizin (3)
- Deutsches Zentrum für Herzinsuffizienz (DZHI) (2)
- Institut für Klinische Epidemiologie und Biometrie (2)
- Institut für diagnostische und interventionelle Neuroradiologie (ehem. Abteilung für Neuroradiologie) (2)
- Institut für Humangenetik (1)
- Institut für Informatik (1)
- Institut für Psychologie (1)
- Institut für diagnostische und interventionelle Radiologie (Institut für Röntgendiagnostik) (1)
Background
The psychometric properties of an instrument, the Activity Scale for Kids-performance (ASKp), were assessed which was proposed to capture physical functioning after allogeneic hematopoietic stem cell transplantation (HSCT). Additionally, this multicenter observational prospective study investigated the influence of clinical correlates focusing on chronic graft-versus-host disease (cGVHD).
Methods
Patient-reported ASKp, clinician-reported Karnofsky/Lansky status (KPS/PSS), patient characteristics and cGVHD details were assessed of 55 patients with a median age of 12 years at baseline after day +100 post-HSCT and every 3 months during the next 18 months. The psychometric properties were evaluated and ASKp and KPS/PSS status was compared using ANOVAS and multiple regression models.
Results
The German version of the ASKp showed good psychometric properties except for ceiling effects. Discrimination ability of the ASKp was good regarding the need for devices but failed to predict cGVHD patients. Both the ASKp and the KPS/PSS were associated with patients after adoptive cell therapy being in need for devices, suffering from overlap cGVHD and from steroid side effects but not with patients’ age and gender. In contrast to the KPS/PSS the ASKp only showed significant differences after merging moderate and severe cGHVD patients when comparing them to No-cGVHD (F = 4.050; p = 0.049), being outperformed by the KPS/PSS (F = 20.082; p < 0.001).
Conclusion
The ASKp showed no clear advantages compared to KPS/PSS even though economical and patients’ effort was higher. Further application range may be limited through ceiling effects. Both should be taken into consideration. Therefore, the results may not support the usage of ASKp after HSCT and rather suggest KPS/PSS, both patient and clinician reported.
Background
The Dermatophagoides pteronyssinus molecule Der p 23 is a major allergen whose clinical relevance has been shown in cross‐sectional studies. We longitudinally analysed the trajectory of Der p 23‐specific IgE antibody (sIgE) levels throughout childhood and youth, their early‐life determinants and their clinical relevance for allergic rhinitis and asthma.
Methods
We obtained sera and clinical data of 191 participants of the German Multicentre Allergy Study, a prospective birth cohort. Serum samples from birth to 20 years of age with sIgE reactivity to Der p 23 in a customised semiquantitative microarray were newly analysed with a singleplex quantitative assay. Early mite exposure was assessed by measuring the average content of Der p 1 in house dust at 6 and 18 months.
Results
Der p 23‐sIgE levels were detected at least once in 97/191 participants (51%). Prevalence of Der p 23 sensitisation and mean sIgE levels increased until age 10 years, plateaued until age 13 years and were lowest at age 20 years. Asthma, allergic rhinitis (AR) and atopic dermatitis (AD) were more prevalent in Der p 23‐sensitised children, including those with monomolecular but persistent sensitisation (11/97, 11%). A higher exposure to mites in infancy and occurrence of AD before 5 years of age preceded the onset of Der p 23 sensitisation, which in turn preceded a higher incidence of asthma.
Conclusions
Der p 23 sensitisation peaks in late childhood and then decreases. It is preceded by early mite exposure and AD. Asthma and AR can occur in patients persistently sensitised to Der p 23 as the only mite allergen, suggesting the inclusion of molecular testing of Der p 23‐sIgE for subjects with clinical suspicion of HDM allergy but without sIgE to other major D.pt. allergens.
A key feature for Internet of Things (IoT) is to control what content is available to each user. To handle this access management, encryption schemes can be used. Due to the diverse usage of encryption schemes, there are various realizations of 1-to-1, 1-to-n, and n-to-n schemes in the literature. This multitude of encryption methods with a wide variety of properties presents developers with the challenge of selecting the optimal method for a particular use case, which is further complicated by the fact that there is no overview of existing encryption schemes. To fill this gap, we envision a cryptography encyclopedia providing such an overview of existing encryption schemes. In this survey paper, we take a first step towards such an encyclopedia by creating a sub-encyclopedia for secure group communication (SGC) schemes, which belong to the n-to-n category. We extensively surveyed the state-of-the-art and classified 47 different schemes. More precisely, we provide (i) a comprehensive overview of the relevant security features, (ii) a set of relevant performance metrics, (iii) a classification for secure group communication schemes, and (iv) workflow descriptions of the 47 schemes. Moreover, we perform a detailed performance and security evaluation of the 47 secure group communication schemes. Based on this evaluation, we create a guideline for the selection of secure group communication schemes.