Theodor-Boveri-Institut für Biowissenschaften
Refine
Year of publication
- 2024 (20)
- 2023 (62)
- 2022 (116)
- 2021 (156)
- 2020 (121)
- 2019 (83)
- 2018 (80)
- 2017 (69)
- 2016 (95)
- 2015 (85)
- 2014 (105)
- 2013 (69)
- 2012 (85)
- 2011 (76)
- 2010 (63)
- 2009 (34)
- 2008 (56)
- 2007 (45)
- 2006 (39)
- 2005 (25)
- 2004 (17)
- 2003 (27)
- 2002 (34)
- 2001 (27)
- 2000 (22)
- 1999 (11)
- 1994 (31)
- 1993 (16)
- 1992 (22)
- 1991 (24)
- 1990 (18)
- 1989 (17)
- 1988 (13)
- 1987 (12)
- 1986 (17)
- 1985 (9)
- 1984 (11)
- 1983 (7)
- 1982 (12)
- 1981 (8)
- 1980 (6)
- 1979 (10)
- 1978 (10)
- 1977 (3)
- 1976 (10)
- 1975 (10)
- 1974 (8)
- 1973 (9)
- 1972 (14)
- 1971 (6)
- 1970 (5)
- 1969 (7)
- 1968 (2)
- 1964 (1)
- 1963 (2)
- 1961 (1)
Document Type
- Journal article (1131)
- Doctoral Thesis (748)
- Conference Proceeding (17)
- Review (16)
- Preprint (12)
- Book article / Book chapter (9)
- Book (3)
- Report (3)
- Master Thesis (2)
- Other (1)
Keywords
- Biochemie (76)
- Taufliege (65)
- Drosophila (47)
- Genexpression (33)
- Biologie (30)
- Drosophila melanogaster (30)
- Maus (29)
- Biene (28)
- Molekularbiologie (25)
- biodiversity (25)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (1943)
- Graduate School of Life Sciences (90)
- Institut für Humangenetik (46)
- Institut für Virologie und Immunbiologie (27)
- Julius-von-Sachs-Institut für Biowissenschaften (25)
- Medizinische Klinik und Poliklinik II (24)
- Rudolf-Virchow-Zentrum (22)
- Center for Computational and Theoretical Biology (19)
- Institut für Pharmakologie und Toxikologie (18)
- Lehrstuhl für Tissue Engineering und Regenerative Medizin (18)
Sonstige beteiligte Institutionen
- Institut für Tierökologie und Tropenbiologie (2)
- Ökologische Station Fabrikschleichach (2)
- Albert-Ludwigs-Universität Freiburg (1)
- Boehringer Ingelheim Pharma GmbH & Co. KG (1)
- Boston Children's Hospital (1)
- Center for Computational and Theoretical Biology (CCTB), Universität Würzburg (1)
- Chemical Biology Laboratory, National Cancer Institue, Frederick (USA) (1)
- Core Unit Systemmedizin (1)
- DNA Analytics Core Facility, Biocenter, University of Wuerzburg, Wuerzburg, Germany (1)
- DNA Analytics Core Facility, Biocenter, University of Würzburg, Würzburg, Germany (1)
ResearcherID
- D-1221-2009 (1)
- J-8841-2015 (1)
- N-2030-2015 (1)
EU-Project number / Contract (GA) number
- 244090 (7)
- 311781 (5)
- 226852 (4)
- 289706 (3)
- 669830 (3)
- 686070 (3)
- 018741 (2)
- 259867 (2)
- 268985 (2)
- 305312 (2)
- 602805 (2)
- 618045 (2)
- 721016 (2)
- 765937 (2)
- 031A408B (1)
- 031A409B (1)
- 115300 (1)
- 20100317 (1)
- 201052 (1)
- 216027 (1)
- 223175 (1)
- 250194 (1)
- 250194-Carnivorom (1)
- 260986 (1)
- 261474 (1)
- 268962 (1)
- 270089 (1)
- 294823 (1)
- 306240 (1)
- 316790 (1)
- 336045 (1)
- 340602 (1)
- 506675 (1)
- 517836 (1)
- 602812 (1)
- 616346 (1)
- 633784 (1)
- 634361 (1)
- 634935 (1)
- 638536 (1)
- 638988 (1)
- 660375 (1)
- 677673 (1)
- 686271 (1)
- 695376 (1)
- 715466 (1)
- 728018 (1)
- 759139 (1)
- 834709 (1)
- 835102) (1)
- 840741 (1)
- 853546 (1)
- CoG 721016–HERPES (1)
- ERC-2018-ADG/NCI-CAD (1)
- ESF_14-BM-A55-0005_16 (1)
Hsp90 is a dimeric molecular chaperone that is essential for the folding and activation of hundreds of client proteins. Co-chaperone proteins regulate the ATP-driven Hsp90 client activation cycle. Aha-type co-chaperones are the most potent stimulators of the Hsp90 ATPase activity but the relationship between ATPase regulation and in vivo activity is poorly understood. We report here that the most strongly conserved region of Aha-type co-chaperones, the N terminal NxNNWHW motif, modulates the apparent affinity of Hsp90 for nucleotide substrates. The ability of yeast Aha-type co-chaperones to act in vivo is ablated when the N terminal NxNNWHW motif is removed. This work suggests that nucleotide exchange during the Hsp90 functional cycle may be more important than rate of catalysis.