540 Chemie und zugeordnete Wissenschaften
Refine
Year of publication
Document Type
- Doctoral Thesis (725)
- Journal article (620)
- Conference Proceeding (10)
- Preprint (6)
- Book article / Book chapter (5)
- Report (2)
- Review (2)
Keywords
- Organische Chemie (127)
- Anorganische Chemie (124)
- Chemie (71)
- Physiologische Chemie (45)
- Bor (25)
- Silicium (25)
- Chemische Synthese (23)
- fluorescence (19)
- Polymere (18)
- Schwertkärpfling (18)
- Supramolekulare Chemie (17)
- boron (17)
- Organische Synthese (16)
- Aminosäuren (15)
- Nanopartikel (15)
- Exziton (14)
- Pharmakokinetik (14)
- Fluoreszenz (13)
- Molekulardynamik (13)
- Sol-Gel-Verfahren (13)
- self-assembly (13)
- Dichtefunktionalformalismus (12)
- Inhibitor (12)
- Muscarinrezeptor (12)
- Naphthylisochinolinalkaloide (12)
- Raman-Spektroskopie (12)
- Selbstorganisation (12)
- Arzneimitteldesign (11)
- Bioisosterie (11)
- Farbstoff (11)
- HPLC (11)
- Quantenchemie (11)
- Wirkstoff (11)
- supramolecular chemistry (11)
- Übergangsmetallkomplexe (11)
- 1 (10)
- Arzneimittel (10)
- DFT (10)
- Fließverhalten (10)
- Hydrogel (10)
- Maus (10)
- Silaanaloga (10)
- Silicate (10)
- Siliciumorganische Verbindungen (10)
- Silicon (10)
- silicon (10)
- Computational chemistry (9)
- Metallocene (9)
- NMR-Spektroskopie (9)
- Stereoselektive Synthese (9)
- Synthese (9)
- Theoretische Chemie (9)
- 3 (8)
- Biomaterial (8)
- Biosynthese (8)
- Bioverfügbarkeit (8)
- Heterocyclische Carbene <-N> (8)
- Kapillarelektrophorese (8)
- Katalyse (8)
- Ligand <Biochemie> (8)
- Merocyanine (8)
- NHC (8)
- Nanostrukturiertes Material (8)
- Schüttgut (8)
- chemistry (8)
- synthesis (8)
- Übergangsmetall (8)
- Asymmetrische Synthese (7)
- Femtosekundenspektroskopie (7)
- Flavonoide (7)
- Hypervalentes Molekül (7)
- Ladungstransfer (7)
- Malaria (7)
- Metabolismus (7)
- Naturstoff (7)
- Perylenbisimid (7)
- Perylenderivate (7)
- Photoionisation (7)
- Proteaseinhibitor (7)
- Proteine (7)
- Replikation (7)
- Rezeptor (7)
- Ruthenium (7)
- Sekundärmetabolit (7)
- Spektroskopie (7)
- Strukturaufklärung (7)
- Totalsynthese (7)
- Wolfram (7)
- drug delivery (7)
- metabolism (7)
- perylene bisimide (7)
- radicals (7)
- Aggregation (6)
- Angeregter Zustand (6)
- Beschichtung (6)
- Biotransformation (6)
- Boron (6)
- Catalysis (6)
- Cysteinproteasen (6)
- Cytotoxizität (6)
- Elektronentransfer (6)
- Enzyminhibitor (6)
- Funktionalisierung <Chemie> (6)
- Isolierung <Chemie> (6)
- Koordinationslehre (6)
- Legionella pneumophila (6)
- Ligand (6)
- Löslichkeit (6)
- Massenspektrometrie (6)
- Molekulare Erkennung (6)
- Pharmakodynamik (6)
- Proteinbindung (6)
- Qualitätskontrolle (6)
- Quantenmechanik (6)
- Reaktivität (6)
- SARS (6)
- SERS (6)
- Stoffwechsel (6)
- Verunreinigung (6)
- Zirkulardichroismus (6)
- amino acids (6)
- antibiotics (6)
- aromaticity (6)
- luminescence (6)
- sol-gel (6)
- transient absorption (6)
- Aggregat <Chemie> (5)
- Analoga (5)
- Anthocyane (5)
- Arzneimittelforschung (5)
- Bindungsaktivierung (5)
- Borole (5)
- Borylene (5)
- Click-Chemie (5)
- Cyclodextrine (5)
- DNA (5)
- DNS (5)
- Diels-Alder reactions (5)
- Elektronendichte (5)
- Enantioselektivität (5)
- Fließregulierung (5)
- Fotoionisation (5)
- Germanium (5)
- Instrumentelle Analytik (5)
- Kohlenstoff-Nanoröhre (5)
- Kombinatorische Synthese (5)
- Kontrastmittel (5)
- Koordinationschemie (5)
- LC-MS/MS (5)
- Metallocenophane (5)
- Molekulardesign (5)
- NMR-Tomographie (5)
- Nanodiamant (5)
- Naturstoffe (5)
- Pentakoordination (5)
- Phosphane (5)
- Phosphine (5)
- Photochemie (5)
- Photodissoziation (5)
- Piperidinderivate (5)
- Platin (5)
- Polyphenole (5)
- Protonen-NMR-Spektroskopie (5)
- Pulver (5)
- REMPI (5)
- RNA (5)
- Radikal <Chemie> (5)
- Raman spectroscopy (5)
- Regulation (5)
- Rhodium (5)
- Ringöffnungspolymerisation (5)
- Sandwich-Verbindungen (5)
- Siliciumkomplexe (5)
- Siloxane (5)
- Sol-Gel (5)
- Stereochemie (5)
- Struktur-Aktivitäts-Beziehung (5)
- Synchrotronstrahlung (5)
- Synthesis (5)
- Triarylamine (5)
- Tuberkelbakterium (5)
- Validierung (5)
- bioisosterism (5)
- capillary electrophoresis (5)
- cyclodextrin (5)
- femtosecond spectroscopy (5)
- flavonoids (5)
- hydrogel (5)
- hydrogels (5)
- molecular dynamics (5)
- pharmacokinetics (5)
- quantum dynamics (5)
- zwitterionic (5)
- 3D-Druck (4)
- Alzheimerkrankheit (4)
- Antagonist (4)
- Antibiotikum (4)
- Aroma (4)
- Aziridine (4)
- Biomarker (4)
- Calciumphosphate (4)
- Candida albicans (4)
- Carbene (4)
- Chemische Bindung (4)
- Chiralität (4)
- Chiralität <Chemie> (4)
- Coronaviren (4)
- Cycloaddition (4)
- Cyclodextrin (4)
- Cyclophane (4)
- Diborane (4)
- Diboren (4)
- Drugs (4)
- Duftstoff (4)
- EPR (4)
- Eisen (4)
- Eisenkomplexe (4)
- Elektrochemie (4)
- Extrakt (4)
- Fließregulierungsmittel (4)
- GC-MS (4)
- Guanidinderivate (4)
- HPLC-MS (4)
- Halbsandwich-Verbindungen (4)
- Homogene Katalyse (4)
- Hybridpolymer (4)
- Hybridpolymere (4)
- Höherkoordination (4)
- Iridiumkomplexe (4)
- Kohlenstoff (4)
- Krebs <Medizin> (4)
- Kristallisation (4)
- Kristallstruktur (4)
- LC-MS (4)
- Lithium-Ionen-Akkumulator (4)
- Lunge (4)
- Maisstärke (4)
- Metallorganische Polymere (4)
- Molybdän (4)
- NIR-Spektroskopie (4)
- NMR spectroscopy (4)
- Natural Products (4)
- Nickel (4)
- Nickelkomplexe (4)
- Oberflächenverstärkter Raman-Effekt (4)
- Onkogen (4)
- Organischer Halbleiter (4)
- Oxidation (4)
- Permeabilität (4)
- Pharmakologie (4)
- Photoelektronenspektroskopie (4)
- Photolumineszenz (4)
- Pyrolyse (4)
- QSAR (4)
- Quantendynamik (4)
- Raman (4)
- Screening (4)
- Signaltransduktion (4)
- Silanole (4)
- Siliciumdioxid (4)
- Sintern (4)
- Squaraine (4)
- Stabilität (4)
- Stereoselektivität (4)
- Tandem-Reaktion (4)
- Targeted drug delivery (4)
- Titandioxid (4)
- Transiente Absorption (4)
- Trypanosomen (4)
- Tumor (4)
- Wirkstoffe (4)
- Wirkstofffreisetzung (4)
- Wittig-Reaktion (4)
- Wolframkomplexe (4)
- Xiphophorus (4)
- Zwitterion (4)
- biofabrication (4)
- boranes (4)
- charge transfer (4)
- circular dichroism (4)
- cytotoxicity (4)
- density functional calculations (4)
- docking (4)
- drug design (4)
- energy transfer (4)
- heterocycles (4)
- ionic liquids (4)
- malaria (4)
- molybdenum (4)
- muscarinic receptors (4)
- nanodiamond (4)
- naphthylisoquinoline alkaloids (4)
- natural products (4)
- non-covalent interactions (4)
- organic synthesis (4)
- pentacoordinate (4)
- photoelectron spectroscopy (4)
- polymers (4)
- polyphenols (4)
- protease (4)
- protease inhibitors (4)
- pyrolysis (4)
- ruthenium (4)
- secondary structure (4)
- stereogen (4)
- stereogenic (4)
- stereoselektive Synthese (4)
- structural elucidation (4)
- structure elucidation (4)
- supramolekulare Chemie (4)
- synchrotron radiation (4)
- total synthesis (4)
- transition metal (4)
- triarylamine (4)
- tungsten (4)
- validation (4)
- virtual screening (4)
- 2 (3)
- 4-0xadiazin-6-ones (3)
- Absolute Configuration (3)
- Acetylcholinesterase (3)
- Adsorption (3)
- Aktivierung <Chemie> (3)
- Amino acids (3)
- Ancistrocladaceae (3)
- Aromastoff (3)
- Asthma (3)
- Auslauftrichter (3)
- Batterie (3)
- Berechnung (3)
- Biogenese (3)
- Biokompatibilität (3)
- Biologischer Abbau (3)
- Biologisches Material (3)
- Biradikal (3)
- Blei (3)
- Blutspiegel (3)
- Borylenkomplexe (3)
- Burkholderia pseudomallei (3)
- CD-Spektroskopie (3)
- Chemometrie (3)
- Cholinesteraseinhibitor (3)
- Chromatographie (3)
- Chromophor (3)
- Circular Dichroism (3)
- Computational Chemistry (3)
- Cycloadditionen (3)
- Cycloadditions (3)
- DNA-Replikation (3)
- DNS-Schädigung (3)
- Diabetes mellitus (3)
- Diamant (3)
- Diboran(4) (3)
- Diffusion (3)
- Docking (3)
- Dünne Schicht (3)
- Eisenoxide (3)
- Elektronenspinresonanz (3)
- Elektrorheologie (3)
- Estradiol (3)
- Extrazelluläre Matrix (3)
- Formulierungsentwicklung (3)
- Gen (3)
- Genexpression (3)
- Gewebe (3)
- Glaskeramik (3)
- HIV (3)
- Heterocyclen (3)
- Hexacoordination (3)
- Hexakoordination (3)
- Hitzeschock-Proteine (3)
- In vitro (3)
- Inhibition (3)
- Insulin-like Growth Factor I (3)
- Ionic Liquids (3)
- KasA (3)
- Kiefernrindenextrakt (3)
- Kinetik (3)
- Knochenzement (3)
- Komplexe (3)
- Konjugate (3)
- Koordinationspolymere (3)
- Laserstrahlung (3)
- Lebendgebärende Zahnkarpfen (3)
- Leishmaniose (3)
- Lewis acid (3)
- Lewis-Base (3)
- Lungenperfusionsmodell (3)
- Magnetische Kernresonanz (3)
- Mangan (3)
- Maschinelles Lernen (3)
- Mehrfachbindung (3)
- Merocyanin (3)
- Metabolit (3)
- Metallkomplexe (3)
- Metalloarenophane (3)
- Metallorganische Chemie (3)
- Metallorganische Verbindungen (3)
- Mikrostruktur (3)
- Muscarinic receptor subtypes (3)
- Muscarinic receptors (3)
- Naphthylisochinoline (3)
- Nichtadiabatischer Prozess (3)
- Nichtlineare Spektroskopie (3)
- Oberfläche (3)
- Oberflächenfunktionalisierung (3)
- Optische Spektroskopie (3)
- Organic Chemistry (3)
- Ormocer (3)
- Oxidativer Stress (3)
- Paracyclophane (3)
- Pentacoordination (3)
- Peptidsynthese (3)
- Permeation (3)
- Pharmacokinetics (3)
- Pharmakotherapie (3)
- Photochemistry (3)
- Photolyse (3)
- Photolysis (3)
- Physikalische Chemie (3)
- Piperidinalkaloide (3)
- Platinkomplexe (3)
- Polycyclische Aromaten (3)
- Proliferation (3)
- Protease (3)
- Protein-Protein-Wechselwirkung (3)
- Protein-Tyrosin-Kinasen (3)
- QM/MM (3)
- Quantitative Analyse (3)
- Radikal (3)
- Raman Spektroskopie (3)
- Reinheitsanalytik (3)
- Replikationsursprung (3)
- Rheologie (3)
- Rhodiumkomplexe (3)
- Ringspannung (3)
- SMN (3)
- Scheibe-Aggregat (3)
- Schwingungsspektroskopie (3)
- Selektivität (3)
- Sensor (3)
- Solubilisation (3)
- Stereoselectivity (3)
- Stickstoffmonoxid (3)
- Strandkiefer (3)
- Struktur (3)
- Strukturbasiertes Wirkstoffdesign (3)
- Supramolecular Chemistry (3)
- TD-DFT (3)
- Theoretical Chemistry (3)
- Thioaldehyde (3)
- Titan (3)
- Toxikologie (3)
- Triphyophyllum peltatum (3)
- Trypanosomiase (3)
- Ultrafiltration (3)
- Ultrakurzzeitspektroskopie (3)
- Viskosität (3)
- Wasserlöslichkeit (3)
- Wasserstoffbrückenbindung (3)
- Wirkstoffdesign (3)
- Zinn (3)
- Zugspannung (3)
- Zwei-Sechs-Halbleiter (3)
- allosteric modulation (3)
- annulation (3)
- ansa-Komplexe (3)
- biosynthesis (3)
- biotransformation (3)
- bismuth (3)
- bond activation (3)
- borylation (3)
- carbanion (3)
- carbenes (3)
- carborane (3)
- catalysis (3)
- chiral separation (3)
- click chemistry (3)
- computational chemistry (3)
- contrast agent (3)
- dyes (3)
- exciton (3)
- flow regulation (3)
- flow regulator (3)
- fluorine (3)
- inflammation (3)
- kinetics (3)
- liquid crystals (3)
- lithium (3)
- macrocycle (3)
- mass spectrometry (3)
- metallocenophanes (3)
- microstructure (3)
- naphthalene diimide (3)
- nicht-kovalente Wechselwirkungen (3)
- optical spectroscopy (3)
- organic chemistry (3)
- organische Halbleiter (3)
- oxidation (3)
- oxidative addition (3)
- pharmacodynamics (3)
- photocatalysis (3)
- photodissociation (3)
- photoionization (3)
- photolysis (3)
- polycyclic aromatic hydrocarbons (3)
- population pharmacokinetics (3)
- protein binding (3)
- quantum chemistry (3)
- reactive intermediates (3)
- replication (3)
- rhodium (3)
- ring-opening polymerization (3)
- screening (3)
- sensor (3)
- single-crystal X-ray study (3)
- singlet oxygen (3)
- stereoselective synthesis (3)
- theranostics (3)
- thermodynamics (3)
- transient absorption spectroscopy (3)
- transition metal complexes (3)
- triarylborane (3)
- virtuelles Screening (3)
- 10-bis(dicarboximide)> (2)
- 4-0xadiazine-2-carboxylate (2)
- 4:9 (2)
- 6 (2)
- ACID (2)
- AMSOL (2)
- Ab-initio-Rechnung (2)
- Absolute Konfiguration (2)
- Absorptionsspektroskopie (2)
- Additive Fertigung (2)
- Addukt (2)
- Agonist (2)
- Alkine (2)
- Alkoxysilane (2)
- Allosterischer Effektor (2)
- Aluminiumnitrid (2)
- Alzheimer-Krankheit (2)
- Amphiphile Verbindungen (2)
- Anthracen (2)
- Anthracenderivate (2)
- Antibiotika (2)
- Arzneimittelüberwachung (2)
- Aspartatproteasen (2)
- Austauschreaktion (2)
- Authentizität (2)
- Azoalkene (2)
- BN compounds (2)
- Bacillus megaterium (2)
- Bacteria (2)
- Benzvalen (2)
- Bioaktive Verbindungen (2)
- Bioaktivität (2)
- Bioassay (2)
- Biodistribution (2)
- Biofabrication (2)
- Bioinks (2)
- Biokatalyse (2)
- Biologische Aktivität (2)
- Bioorganik (2)
- Biosynthesis (2)
- Biradikale (2)
- Bispidinderivate (2)
- Bitopische Liganden (2)
- Bleiakkumulator (2)
- Blut-Hirn-Schranke (2)
- Bond Activation (2)
- Borane (2)
- Borheterocyclen (2)
- Borirene (2)
- Borolderivate (2)
- Borylen (2)
- Borylenkomplex (2)
- Borylgruppe (2)
- Brust (2)
- Burkholderia (2)
- C-coupled naphthylisoquinoline alkaloids (2)
- C/Si-Austausch (2)
- C/Si-Bioisosteric Investigations (2)
- C/Si-Bioisostric Investigations (2)
- CARS-Spektroskopie (2)
- Capillary Electrophoresis (2)
- Carbamate (2)
- Carbazolderivate (2)
- Carbocations (2)
- Cathepsin (2)
- Chemische Analyse (2)
- Chirale Verbindungen (2)
- Chirality (2)
- Chlorinderivate (2)
- Circular-Dichroismus (2)
- Cobalt (2)
- Coordination Chemistry (2)
- Copolymerisation (2)
- Coupled Cluster (2)
- Crystal Structure (2)
- Cyclo-GMP (2)
- Cyclopentadienderivate (2)
- Cyclovoltammetrie (2)
- Cytochrom P-450 (2)
- DBH (2)
- DFT calculations (2)
- DNA replication (2)
- Derivatisierung (2)
- Diborane(4) (2)
- Difenidol (2)
- Dimere (2)
- Dimerisierung (2)
- Dioncophyllaceae (2)
- Dipolare Cycloaddition (2)
- Docking <Chemie> (2)
- Donator <Chemie> (2)
- Doppelbindung (2)
- Drug design (2)
- Durchstrahlungselektronenmikroskopie (2)
- Dünnschichttransistor (2)
- EPR spectroscopy (2)
- Elektronendichteverteilung (2)
- Elektronenspinresonanzspektroskopie (2)
- Elektronensprayionisations-Massenspektrometrie (2)
- Embryonalentwicklung (2)
- Enantiomerentrennung (2)
- Enantioselectivity (2)
- Endoribonuklease P (2)
- Endothelzelle (2)
- Energietransfer (2)
- Enol Iactones (2)
- Enoyl-ACP-Reduktase (2)
- Entropie (2)
- Entstehung (2)
- Entzündung (2)
- Enzymkinetik (2)
- Ephedrin (2)
- Epoxidation (2)
- Epoxidierung (2)
- Erdbeere (2)
- Etacrynsäure (2)
- Europäisches Arzneibuch (2)
- Exziton-Exziton-Annihilierung (2)
- Exzitonenkopplung (2)
- FRET (2)
- FabI (2)
- Ferrocen (2)
- Festkörperoberfläche (2)
- Fibroblastenwachstumsfaktor (2)
- Fingerprint-Verfahren (2)
- Fish (2)
- Fließeigenschaften (2)
- Fließfähigkeit (2)
- Fluid-Feststoff-System (2)
- Fluorescence (2)
- Fluoreszenz-Resonanz-Energie-Transfer (2)
- Foldamers (2)
- Formulation development (2)
- Formulierung (2)
- Freie-Elektronen-Laser (2)
- Fumonisine (2)
- Furaneol (2)
- G-Protein-gekoppelter Rezeptor (2)
- G-Proteine (2)
- G-quadruplexes (2)
- GPCR (2)
- GTP-bindende Proteine (2)
- Gadolinium (2)
- Gasphase (2)
- Genanalyse (2)
- Gentamicin (2)
- Glas (2)
- Globale Optimierung (2)
- Glucocorticoide (2)
- Glucocorticosteroide (2)
- Glutathion (2)
- Glycoengineering (2)
- Glykosylierung (2)
- Gold (2)
- Granulieren (2)
- Guanidiniocarbonylpyrrol (2)
- Halbleiter (2)
- Heidelbeere (2)
- Heilpflanzen (2)
- Heparin (2)
- Hepatotoxizität (2)
- Heterogene Katalyse (2)
- Hexahydro-sila-difenidol analogues (2)
- Hispidulin (2)
- Humanstoffwechsel (2)
- Hybrid Polymer (2)
- Hydrogels (2)
- Hydrolyse (2)
- Hydrophosphinierung (2)
- Hydroxycarbonsäuren (2)
- IR spectroscopy (2)
- Imatinib (2)
- Implantat (2)
- Impurity Profiling (2)
- In vivo (2)
- Infektionskrankheit (2)
- Infektionskrankheiten (2)
- Infrared and Raman spectroscopy (2)
- Infrarot (2)
- Infrarot- und Raman-Spektroskopie (2)
- Infrarot-Spektroskopie (2)
- InhA (2)
- Inhalation (2)
- Initiation (2)
- Interaktion (2)
- Interleukin 4 (2)
- Ionische Flüssigkeit (2)
- Ionische Flüssigkeiten (2)
- Iridium (2)
- Iron (2)
- Isotopenverhältnis-Massenspektrometrie (2)
- Japankärpfling (2)
- Kalorimetrie (2)
- Keimbildung (2)
- Keramik (2)
- Ketenes (2)
- Kinaseinhibitor (2)
- Knochen (2)
- Knochenersatz (2)
- Knockout <Molekulargenetik> (2)
- Kohlenstoffnanoröhre (2)
- Koordinationsverbindungen (2)
- Koordinativ ungesättigte Verbindungen (2)
- Kristallstrukturanalyse (2)
- Lanthanoide (2)
- Lead-acid batteries (2)
- Lebensmittelchemie (2)
- Leber (2)
- Lebertoxizität (2)
- Legionärskrankheit (2)
- Leishmania (2)
- Lewis acids (2)
- Lewis-Säure (2)
- Lipide (2)
- Lipoxygenase <5-> (2)
- Lithium-Ionen-Batterie (2)
- Lithiumorganische Verbindungen (2)
- Lumineszenz (2)
- MRI (2)
- Makrozyklus (2)
- Marcophage-infectivity-potentiator-Protein (2)
- Mechanismus (2)
- Mehrzähniger Ligand (2)
- Melanom (2)
- Melatonin (2)
- Membran (2)
- Messenger-RNS (2)
- Metallo-silanole (2)
- Metalloarenophanes (2)
- Metallocenophanes (2)
- Metallorganisches Netzwerk (2)
- Methodenentwicklung (2)
- Methylierung (2)
- Mikro-Raman-Spektroskopie (2)
- Mikroemulsion (2)
- Mikroorganismus (2)
- Molecular Dynamics (2)
- Molecular dynamics (2)
- Molekularbewegung (2)
- Molekulargenetik (2)
- Molekülbibliothek (2)
- Monoschicht (2)
- Multiple Myeloma (2)
- Multiples Myelom (2)
- Multipolverfeinerung (2)
- Muscarin (2)
- Muscarinic receptor antagonists (2)
- Muskarinrezeptor (2)
- N (2)
- N-heterocyclic carbene (2)
- NMR (2)
- NMR-spectroscopy (2)
- Nanodraht (2)
- Naphthylisochinolin-Alkaloide (2)
- Naturstoffchemie (2)
- Neuroprotektion (2)
- Nucleophile Substitution (2)
- ORC (2)
- Organic Synthesis (2)
- Organischer Feldeffekttransistor (2)
- Osteoarthritis (2)
- PNA (2)
- PRMT5 (2)
- PZT (2)
- Parkinson (2)
- Parkinson-Krankheit (2)
- Peptide (2)
- Pericyclische Reaktion (2)
- Perylen (2)
- Perylenbisdicarboximide <Perylen-3 (2)
- Pflanzen (2)
- Pflanzeninhaltsstoff (2)
- Pharmacokinetic (2)
- Pharmazeutische Technologie (2)
- Pharmazeutischer Hilfsstoff (2)
- Phosphan (2)
- Phosphor (2)
- Photochromie (2)
- Photolithographie (2)
- Photophysik (2)
- Photopolymerisation (2)
- Photosensibilisator (2)
- Plasmodium falciparum (2)
- Plasmozytom (2)
- Polarität (2)
- Poly(2-oxazolin)e (2)
- Poly(2-oxazoline)s (2)
- Polydimethylsiloxane (2)
- Polyethylenglykole (2)
- Polyimido Anions (2)
- Polyimidoanionen (2)
- Polyketide (2)
- Polymer (2)
- Polyoxazoline (2)
- Polysiloxan-Membranen (2)
- Polysiloxane-Membranes (2)
- Populationskinetik (2)
- Populationspharmakokinetik (2)
- Porphyrin (2)
- Porphyrine (2)
- Procyanidine (2)
- Promotor (2)
- Präparative organische Chemie (2)
- Pseudodistomin E (2)
- Pseudodistomine (2)
- Pump-Probe-Technik (2)
- Pycnogenol (2)
- Quantifizierung (2)
- Quantum Chemistry (2)
- Quantum dynamics (2)
- R factor = 0.027 (2)
- RNA-dependent RNA polymerase (2)
- RNS-Spleißen (2)
- RNase P (2)
- Random Chemistry (2)
- Ratte (2)
- Reaktionskinetik (2)
- Reaktionsmechanismus (2)
- Reaktive Zwischenstufe (2)
- Resonanz-Raman (2)
- Resonanz-Raman-Effekt (2)
- Rinde (2)
- Ruthenium complexes (2)
- Rutheniumkomplexe (2)
- Räumliche Verteilung (2)
- STEC (2)
- Schlafkrankheit (2)
- Schwefelorganische Verbindungen (2)
- Schwefelylide (2)
- Schüttgüter (2)
- Sekundärstruktur (2)
- Selbstassoziation (2)
- Selen (2)
- Serumalbumine (2)
- Silanderivate (2)
- Silanol (2)
- Siliciumcarbid (2)
- Siliciumhaltige Synthesebausteine (2)
- Silicon-containing building blocks (2)
- Silylen (2)
- Silylierung (2)
- Simulation (2)
- Singlet Oxygen (2)
- Singulettsauerstoff (2)
- Small nuclear RNP (2)
- Spartein (2)
- Spectroscopy (2)
- Spektroelektrochemie (2)
- Spin density (2)
- Spinchemie (2)
- Spiralstrahlmühle (2)
- Stability (2)
- Staphylococcus aureus (2)
- Statistische Thermodynamik (2)
- Sternpolymere (2)
- Streptomyces (2)
- Structure-based drug design (2)
- Struktur-Aktivitäts-Beziehungsstudien (2)
- Sulfur Ylides (2)
- Supramolekulare Struktur (2)
- Synthesediamant (2)
- T-Zellen (2)
- TDM (2)
- Tandem Wittig-[3+2]-Cycloaddition (2)
- Tandem-Massenspektrometrie (2)
- Tantal (2)
- Terpyridin <2,2':6',2''-> (2)
- Therapeutic Systems (2)
- Therapeutische Systeme (2)
- Therapeutisches Drug Monitoring (2)
- Thermodynamik (2)
- Tissue Engineering (2)
- Topologie (2)
- Total synthesis (2)
- Transgene Tiere (2)
- Transkriptionsfaktor (2)
- Triarylamin (2)
- Triphyophyllum (2)
- Tungsten (2)
- UV-spectroscopy (2)
- Ultraviolett-Photoelektronenspektroskopie (2)
- Umweltfaktor (2)
- Valeriana wallichii (2)
- Vanadium (2)
- Velocity-Map-Imaging (2)
- Verkapselung (2)
- Vernetzung <Chemie> (2)
- Verunreinigungsprofil (2)
- Vierwellenmischung (2)
- Virtuelles Screening (2)
- Wirbelschichtgranulation (2)
- Wirbelschichtverfahren (2)
- Wirkmechanismus (2)
- Wirkstoff-Rezeptor-Bindung (2)
- Wirkstoff-Träger-System (2)
- Wärmeleitfähigkeit (2)
- X-ray crystallography (2)
- Zeitabhängige Dichtefunktionaltheorie (2)
- Zelladhäsion (2)
- Zellzyklus (2)
- Zeolith (2)
- Zink (2)
- adduct (2)
- albumin (2)
- alignment (2)
- anisotropy (2)
- ansa-Metallocene (2)
- anthocyanins (2)
- antibacterial activity (2)
- antileishmanial (2)
- apple juice (2)
- artificial photosynthesis (2)
- asthma (2)
- at-metal-chiral rhenium complexes (2)
- authenticity (2)
- axial chirality (2)
- aziridines (2)
- azulene (2)
- baclofen (2)
- binding affinity (2)
- biocatalysis (2)
- biocompatibility (2)
- bioconjugation (2)
- biomarker (2)
- biomaterials (2)
- biophysics (2)
- biradicals (2)
- bonding (2)
- borole (2)
- borylene (2)
- bulk polarity (2)
- bulk powders (2)
- cGMP (2)
- calcium phosphate (2)
- carcinogenicity (2)
- cationic species (2)
- cell imaging (2)
- charge density (2)
- chemical crosslinking (2)
- chiral (2)
- chiral phosphines (2)
- chirale Phosphane (2)
- chirality (2)
- combinatorial chemistry (2)
- cooperativity (2)
- coordination chemistry (2)
- coordination polymer (2)
- copper (2)
- corn starch (2)
- coronavirus (2)
- covalent inhibitors (2)
- cross-coupling (2)
- crystal structure (2)
- crystal structure analysis (2)
- crystallization (2)
- cyclophanes (2)
- cysteine protease (2)
- cytotoxic activity (2)
- dehydrocoupling (2)
- diffusion (2)
- drugs (2)
- dualsteric ligands (2)
- dye (2)
- dyes/pigments (2)
- electrochemistry (2)
- electron density distribution (2)
- electron transfer (2)
- encapsulation (2)
- endothelial cell (2)
- endothelium (2)
- epoxidation (2)
- etacrynic acid (2)
- excited states (2)
- femtochemistry (2)
- flavor (2)
- flavour (2)
- flowability (2)
- fluorescent probes (2)
- fluoroarene (2)
- free electron laser (2)
- fullerenes (2)
- functionalization (2)
- furan (2)
- g-Tensor (2)
- g-tensor (2)
- gadolinium (2)
- gas phase (2)
- germanium (2)
- glidants (2)
- guanidiniocarbonyl pyrrole (2)
- helicene (2)
- hexahydro- (2)
- higher-coordinate (2)
- hispidulin (2)
- homogeneous catalysis (2)
- hydrolysis (2)
- höherkoordiniertes Silicium (2)
- impurities (2)
- in vitro (2)
- infectious disease (2)
- infectious diseases (2)
- infrared (2)
- infrared spectroscopy (2)
- inhibition (2)
- inhibitors (2)
- inorganic chemistry (2)
- interleukin-4 (2)
- isotope ratio mass spectrometry (2)
- leishmaniasis (2)
- lithium-ion battery (2)
- liver (2)
- lung (2)
- main group elements (2)
- manganese (2)
- matrix metalloproteinase (2)
- mechanism (2)
- melt electrowriting (2)
- membrane (2)
- method development (2)
- methyl 6-oxo-5-phenyl- (2)
- micelles (2)
- microscopy (2)
- migration (2)
- modelling (2)
- molecular modeling (2)
- molecular recognition (2)
- molekulardynamische Simulationen (2)
- multipole refinement (2)
- muscarinic antagonists (2)
- muscarinic receptor (2)
- muscarinic receptor subtypes (2)
- nano (2)
- nanoparticles (2)
- neuroprotection (2)
- noncovalent interactions (2)
- oral bioavailability (2)
- organic semiconductor (2)
- organic semiconductors (2)
- organic solar cells (2)
- organische Solarzelle (2)
- organosilicon (2)
- outflow funnel (2)
- peptides (2)
- permeability (2)
- permeation (2)
- pharmacokinetic (2)
- phosphatase (2)
- photoinduced electron transfer (2)
- photoionisation (2)
- photoluminescence (2)
- piperidine derivatives (2)
- plant extract (2)
- poly(2-ethyl-2-oxazoline) (2)
- poly(2-oxazine) (2)
- poly(2-oxazoline) (2)
- poly(2-oxazoline)s (2)
- polycycles (2)
- precipitated silica (2)
- preparation (2)
- prodrug (2)
- protease inhibitor (2)
- protein (2)
- präreplikativer Komplex (2)
- pseudodistomine E (2)
- pulse shaping (2)
- quantitative analysis (2)
- radical (2)
- radical anion (2)
- radical reactions (2)
- random chemistry (2)
- reactivity (2)
- receptor (2)
- receptors (2)
- redox cascade (2)
- regulation (2)
- reproductive success (2)
- resonance Raman (2)
- rhodesain (2)
- rotational unsymmetric substituents (2)
- rotationsunsymmetrische Substituenten (2)
- scaffold (2)
- silicium (2)
- silyllithium (2)
- sintering (2)
- solubility (2)
- solvatochromism (2)
- spectroscopy (2)
- spiral jet mill (2)
- staphylococcus aureus (2)
- stereoselective (2)
- strategy (2)
- structure-activity relationship (2)
- structure-activity relationships (2)
- structure-activity-relationship studies (2)
- supercritical solvents (2)
- superkritische Lösungsmittel (2)
- supramolecular (2)
- supramolekular (2)
- supraparticles (2)
- tandem Wittig-[3+2]-cycloaddition reaction (2)
- theoretical chemistry (2)
- therapy (2)
- thin film transistor (2)
- thioaldehyde complexes (2)
- thioaldehydes (2)
- time-resolved spectroscopy (2)
- tin (2)
- titania (2)
- titanium (2)
- topology (2)
- transiente Absorption (2)
- transiente Absorptionsspektroskopie (2)
- transition metal complex (2)
- trypanosomiasis (2)
- two-photon absorption (2)
- ultrafiltration (2)
- vanadium (2)
- viscisity (2)
- water purification (2)
- y-oxo- (2)
- Öl (2)
- Übergangsmetallverbindungen (2)
- Übergangszustand (2)
- π-conjugated systems (2)
- "Random Chemistry" (1)
- "steepest descent-modest ascent" (1)
- "steilsten Abstieg - schwächste Aufstieg" (1)
- 'Lacton-Konzept' (1)
- 'lactone concept' (1)
- (+)-Catechin (1)
- (6,5)-SWNT (1)
- (AB)\(_{n}\) segmented copolymers (1)
- (Acetoxymethyl)methylphenylgermane (1)
- (Acetoxymethyl)methylphenylsilane (1)
- (Hydroxymethyl)diphenyl(piperidinoalkyl)silanes (1)
- (R)- and (S)-hexahydro- / Antimuscarinic properties / Muscarinic receptor subtypes (1)
- (bi)pyridine-based ligand (1)
- (± )-dioncophyllacine A (1)
- - (1)
- 04ligand (1)
- 0]hexane (1)
- 1' -c]naphthalene (1)
- 1,2-azaborinine (1)
- 1,3,2,4-Diazadiboretidin-2-yl-Ligand (1)
- 1,4-Diborabenzene (1)
- 1,4-naphthoquinone (1)
- 1-aryl- (1)
- 1-dibromo-1a (1)
- 10 (1)
- 11-dihydro- / 1-Pyrazoline (1)
- 17beta-Estradiol (1)
- 17beta-estradiol (1)
- 2"-> (1)
- 2':6' (1)
- 2,5-diketopiperazines (1)
- 2-(Phenylsulfonylmethyl)-piperidin (1)
- 2-(Phenylsulfonylmethyl)-piperidine (1)
- 2-Bismethylenecyclobutanes (1)
- 2-Bismethylenecyclohexane (1)
- 2-Cyclopentanedione derivatives (1)
- 2-Methylallyl (1)
- 2-Norcaranols (1)
- 2-Thiazaphospholidines (1)
- 2-a:6 (1)
- 2-alkylbranched acids (1)
- 2-chloro (1)
- 2-halo (1)
- 2-imino- (1)
- 2-methylallyl (1)
- 2-α:2' (1)
- 29Si and 15N (1)
- 29Si-NMR (1)
- 3 D bioprinting (1)
- 3-(R)-Hydroxysäuren (1)
- 3-(R)-hydroxy acids (1)
- 3-Azabicyclo{3 (1)
- 3-Cyclopenrtandiyl Radikalkationen (1)
- 3-Cyclopentanediyl Radical Cations (1)
- 3-Methenonaphthalenes (1)
- 3-aryl- (1)
- 3-cyclohexadiene (1)
- 3-dipolar cycloaddition (1)
- 3-dipolare Cycloaddition (1)
- 3-n-butyl-N-phenyl- (1)
- 3D Bioprinting (1)
- 3D Printing (1)
- 3D powder printing (1)
- 3D printing (1)
- 4 (1)
- 4-Chinolonamid (1)
- 4-Pentadienylamine (1)
- 4-dimethylamino-4′-cyanodiphenylacetylene (1)
- 4-quinolone (1)
- 4-quinolone-derivatives (1)
- 4-tetrahydro- (1)
- 4</sup>.0<sup>3 (1)
- 4D-QSAR (1)
- 4]0xadiazino[4 (1)
- 4]non-7-en-6-ylpotassium (1)
- 4a (1)
- 5 (1)
- 5-Aminopiperidylessigsäuren (1)
- 5-Dimethyl-4-hydroxy-3(2H)-furanon (1)
- 5-Dimethyl-4-hydroxy-3(2H)-furanone (1)
- 5-Dimethyl-4-methoxy-3(2H)-furanon (1)
- 5-Dimethyl-4-methoxy-3(2H)-furanone (1)
- 5-a']diindol (1)
- 5-a']diindole (1)
- 5-aminopiperidylaceticacid (1)
- 5-b']diindol (1)
- 5-b']diindole (1)
- 5-b]isoquinolin-1-one derivatives (1)
- 5-dinitrobenzoates (1)
- 5</sup>]beptanes (1)
- 5H-Dibenzo[a (1)
- 5]cyclohepta[ 1 (1)
- 5]diazocino[1 (1)
- 6-Norpinanols (1)
- 6-Norpinyl 3 (1)
- 6-Thiatricyclo[3.2.1.o 2.7 ]oct-3-ene 6 (1)
- 6-aryl- (1)
- 6-dibromo-3-phenyl- (1)
- 6-dioxide (1)
- 6-phenyl (1)
- 6H-1 (1)
- 6a-Tetrahydro-2H-cyclobuta[b]pyrans (1)
- 7 (1)
- 7-Norcaranylidene carbenoid (1)
- 7-dibromo (1)
- 77-LH-28-1 (1)
- 7</sup>]heptane derivatives (1)
- 7SK RNA (1)
- 7b-tetrahydro- (1)
- 8 (1)
- 8-Oxo-2’-desoxyguanosin (1)
- 8-Tetrahydro-3H-2-benzopyrans (1)
- 8-oxo-2'-deoxyguanosine (1)
- 8a-Tetrahydro-2H-1-benzopyran (1)
- 9-Oxabispidin (1)
- 9-Oxabispidine (1)
- 9-oxabispidine (1)
- 9-oxabispidines (1)
- A-Frame-Komplex (1)
- AAZTA-based ligands (1)
- AAZTA-basierte Liganden (1)
- ABC-Transporter (1)
- ADAM-10 (1)
- ADME analysis (1)
- AF-DX 116 (1)
- AIM (1)
- AL amyloidosis (1)
- AL-Amyloidose (1)
- AOM/DSS (1)
- ATG proteins (1)
- ATG12-ATG5 conjugate (1)
- ATP-Abhängigkeit (1)
- ATP-dependent (1)
- Absolutkonfiguration (1)
- Absorption (1)
- Abstimmbarer Laser (1)
- Acene (1)
- Acetaminophen (1)
- Acetophenon (1)
- Acetylcysteinderivate (1)
- Acetylneuraminsäure <N-> (1)
- Achillea Fragrantissima (1)
- Acridiziniumsalze (1)
- Actinoide (1)
- Activation (1)
- Acylierte Quercetin-Tri-Glukoside (1)
- Acyltransferasen (1)
- Additiv (1)
- Additive Manufacturing (1)
- Adenosin (1)
- Adhäsion (1)
- Adhäsive Restauration (1)
- Adiabatische Kalorimetrie (1)
- Adipic acid (1)
- Adipose Tissue (1)
- Adrenerger Neuronenblocker (1)
- Adrenergic neurone blocking agent (1)
- Adsorptionsisotherme (1)
- Adverse outcome pathway (AOP) (1)
- Aerosil (1)
- Aerosile (1)
- Aerosol (1)
- Aescin (1)
- Affinitätsindex (1)
- African sleeping sickness (1)
- Aggregate (1)
- Agomelatin (1)
- Ah Rezeptor (1)
- Ah receptor (1)
- Airborne particles (1)
- Akarizid (1)
- Akkumulator (1)
- Akt (1)
- Akt/PKB (1)
- Aktin Zytoskelett (1)
- Aktiver Transport (1)
- Akzeptor <Chemie> (1)
- Akzeptorgruppe (1)
- Al-Cu (1)
- Al2O3 (1)
- Albumin (1)
- Aldehyde (1)
- Aldehyde Bioconjugation (1)
- Aldehydreductase (1)
- Aldose Reductase (1)
- Aldose Reduktase (1)
- Aldosteron (1)
- Alignment (1)
- Alkamiden (1)
- Alkamides (1)
- Alkene (1)
- Alkohol (1)
- Alkoxylierung (1)
- Alkoxylradikale (1)
- Alkoxylradikals (1)
- Alkyl(amino)carbene (1)
- Alkylidenboryl komplexe (1)
- Alkylpyrazine (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Alkyltrialkoxysilan (1)
- Alkyne (1)
- Allenes (1)
- Allergie (1)
- Allergy (1)
- Allostere Modulation (1)
- Allosterer Modulator (1)
- Allosteric Modulator (1)
- Allosterisch Modurator (1)
- Allyl (1)
- Allylalkohol (1)
- Allylalkohole (1)
- Allylic Amination (1)
- Allylische Aminierung (1)
- Allylradikal (1)
- Aloe <Gattung> (1)
- Aloe saponaria (1)
- Alpha-1-Rezeptor (1)
- Alpha-2-Rezeptor (1)
- Aluminium nitride (1)
- Aluminium-copper (1)
- Aluminiumlegierung (1)
- Aluminiumlegierungen (1)
- Alzheimer (1)
- Alzheimer's Disease (1)
- Alzheimer′s disease (1)
- Amazon Molly (1)
- Ambulante Behandlung (1)
- Amido (1)
- Amino Acid Extraction (1)
- Amino Acid Transport (1)
- Aminoethanolderivate (1)
- Aminoglykoside (1)
- Aminosäure (1)
- Aminosäurederivate (1)
- Aminosäurentransport (1)
- Ammoniumverbindungen (1)
- Amphetamin (1)
- Amyloid <beta-> (1)
- Amyloidose (1)
- Anacardic acid derivatives (1)
- Anacardsäurederivate (1)
- Analyse (1)
- Analytische Chemie (1)
- Anandamid (1)
- Anchimeric assistance in solvolysis (1)
- Ancistrocladinium A (1)
- Ancistrocladus (1)
- Ancistrocladus benomensis (1)
- Ancistrocladus cochinchinenesis (1)
- Ancistrocladus cochinchinensis (1)
- Ancistrocladus griffithii (1)
- Ancistrocladus tanzaniensis (1)
- Ancistrogriffin (1)
- Ancistrogriffine (1)
- Ancistrogriffithin A (1)
- Ancistrogriffithine A (1)
- Anellierung (1)
- Angeborene Immunität (1)
- Angiotensin II (1)
- Anion (1)
- Anisotropie (1)
- Anorganische Analyse (1)
- Anorganische Beschichtung (1)
- Anorganische Synthese (1)
- Anrege-Abfrage-Spektroskopie (1)
- Anthracene derivatives (1)
- Anthrachinonfarbstoff (1)
- Antiaromaticity (1)
- Antiaromatizität (1)
- Antibiotic (1)
- Antidesma (1)
- Antidesma membranaceum (1)
- Antigen (1)
- Antigen CD163 (1)
- Antiinflammatorisch (1)
- Antikörper (1)
- Antimalariamittel (1)
- Antimikrobieller Wirkstoff (1)
- Antioxidans (1)
- Antiphlogistikum (1)
- Antipsychotika (1)
- Antiseptikum (1)
- Antitrypanosomal (1)
- Antitrypanosomen (1)
- Antitumor (1)
- Antitumor-Antibiotikum (1)
- Antitumor-antibitioc (1)
- Antivira (1)
- Apfelsaft (1)
- Aplysiapyranoide (1)
- Apobec (1)
- Arabidopsis (1)
- Arabidopsis thaliana (1)
- Arabischer Kaffee (1)
- Aromaprofil (1)
- Aromaten (1)
- Arsan (1)
- Artemisia dracunculus (1)
- Arterioles (submucosal) (1)
- Arthrose (1)
- Arylamine (1)
- Arylgruppe (1)
- Arzneimittelfälschungen (1)
- Arzneimittelwechselwirkung (1)
- Arzneistoffe (1)
- Arzneistofftransporter (1)
- Aspartat-Proteasen (1)
- Aspergillose (1)
- Aspergillosis (1)
- Aspergillus niger (1)
- Astrochemie (1)
- Asymmetrie (1)
- Ataxia telangiectasia (AT) (1)
- Ataxia teleangiectatica (1)
- Atemwege (1)
- Atomic and molecular interactions with photons (1)
- Atomisierungsenergien (1)
- Atropin (1)
- Atropisomere (1)
- Atropisomerie (1)
- Aufladung (1)
- Auflösungsraten (1)
- Aufmerksamkeitsdefizit-Syndrom (1)
- Auge (1)
- Auger-Spektroskopie (1)
- Aulonocara (1)
- Aurora-A (1)
- Aurora-A-MYCN-Komplex (1)
- Aushärtung (1)
- Ausrichtung (1)
- Ausscheidungen (1)
- Ausscheidungshärtung (1)
- Autodetachment (1)
- Automatisierung (1)
- Autoradiographie (1)
- Autoradiography (1)
- Außenluftfeuchte (1)
- Axialchiralität (1)
- Axiale Chiralität (1)
- Aza-Peptide (1)
- Aza-Peptides (1)
- Azaborinin (1)
- Azaborinine (1)
- Azapeptide (1)
- Aziridin (1)
- Aziridin-2-carboxylate (1)
- Aziridines (1)
- Azofarbstoff (1)
- Azolate (1)
- Azolates (1)
- Azole (1)
- Azoles (1)
- B,N-heterocycles (1)
- B-N-Kupplung (1)
- B3LYP Clusternäherung (1)
- BB bond activation (1)
- BB/BC Bond activation (1)
- BC bond activation (1)
- BSA (1)
- BZ reaction (1)
- BZ-Reaktion (1)
- BaTiO3 (1)
- Bacillus anthracis (1)
- Baclofen (1)
- Bakterien (1)
- Bakteriochlorophyll (1)
- Baltic Sea (1)
- Barbaralane derivatives (1)
- Barbituric Acid Merocyanines (1)
- Barium (1)
- Bariumtitanat (1)
- Barriere (1)
- Base pairing (1)
- Basenpaarung (1)
- Basin-Hopping (1)
- Bassanit (1)
- Bearbeitbarkeit (1)
- Beclomethason (1)
- Beclomethasondipropionat (1)
- Belousov-Zabotinskij-Reaktion (1)
- Benchmark (1)
- Benzocycloheptene derivatives (1)
- Benzodiazepin-Rezeptor-Liganden (1)
- Benzodiazepine receptor ligands (1)
- Benzothiazolderivate (1)
- Benzvalene (1)
- Benzylradikal (1)
- Benzyne (1)
- Beschichtungen (1)
- Beta-2-Rezeptor (1)
- Betalaine (1)
- Betanin (1)
- Betanine (1)
- Bexaroten (1)
- Biaryle (1)
- Bicyclo[1.1.0]butane derivatives (1)
- Bicyclo[1.1.0]butanes (1)
- Bicyclo[1.1.0]butylcarbinyl sulfonates (1)
- Bicyclo[2.1.l]hexan-5-one (1)
- Bicyclo[3.2.0.0<sup>2 (1)
- Bicyclo[3.2.0]hept-6-ene derivatives (1)
- Bicyclo[3.2.1]oct-3-en-2-yl anions (1)
- Bicyclobutanderivate (1)
- Bicyclobutane (1)
- Bicyclobutanes (1)
- Bile (1)
- Bimolekulare Reaktion (1)
- Bindemechanismus (1)
- Bindungsaffinität (1)
- Bindungsaktivierung <Chemische Bindung> <Aktivierung, Chemie> (1)
- Bindungsanalyse (1)
- Bindungskonstante (1)
- Bindungslängenalternanz (1)
- Bindungslängenalternanz in Aromaten (1)
- Bindungspolarisation (1)
- Bindungsverhältnisse (1)
- Bioabbaubarkeit (1)
- Bioaccessibility (1)
- Bioactivity (1)
- Bioanalytik (1)
- Bioanorganik (1)
- Bioavailability (1)
- Biochemistry (1)
- Biodegradability (1)
- Bioengineering (1)
- Biofabrication of hydrogels (1)
- Biofabrikation (1)
- Biofunctionality (1)
- Biofunktionalität (1)
- Biogenesis Ancistrocladus griffithii (1)
- Biohydroxylierung (1)
- Bioink (1)
- Biokonjugate (1)
- Biokonversion (1)
- Biolabelling (1)
- Biolayerinterferometrie (1)
- Biologisches System (1)
- Biolumineszenz-Resonanzenergie-Transfer (1)
- Biomimetik (1)
- Biomineralisation (1)
- Biomolekül (1)
- Bioorganic Chemistry (1)
- Bioorganic chemistry (1)
- Bioorganische Chemie (1)
- Bioorganometallchemie (1)
- Bioorganosilicon chemistry (1)
- Bioorthogonal (1)
- Bioorthogonal Tag (1)
- Bioradicals (1)
- Bioradikale (1)
- Biosensor (1)
- Biotinten (1)
- Bipyridinediylbisboranes / Redox systems / Cyclovoltammetry (1)
- Biradicals (1)
- Bis(catecholato)diboran (1)
- Bis(diorganyldithiocarbamato)organylphosphanes (1)
- Bis(phosphanyle) (1)
- Bis(phosphanyles) (1)
- Bis(pinakolato)diboran (1)
- Bis(triethoxysilyl)ethan (1)
- Bis-Tacrine (1)
- Bis-diimidosulfinate (1)
- Bis-diimidosulfinates (1)
- Bis-triimidosulfonate (1)
- Bis-triimidosulfonates (1)
- Bis[1,2-benzendiolato(2-)][(morpholinio)alkyl]silicates (1)
- Bis[1,2-benzenediolato(2-)][2-(dimethylammonio)phenyl]silicate (1)
- Bis[2,3-naphthalenediolato(2-)][(morpholinio)alkyl]silicates (1)
- Bis[2,3-naphthalenediolato(2-)][2-(dimethylammonio)phenyl]silicate (1)
- Bisbenzo[ 4 (1)
- Bisoprolol (1)
- Bisphenol A (1)
- Bisphosphonate (1)
- Bispidin (1)
- Bitopic Ligands (1)
- Bivalente Hybridverbindungen (1)
- Blaubeere (1)
- Blei-Säure (1)
- Blei-Säure-Batterie (1)
- Blinddarm (1)
- Blockcopolymere (1)
- Blood Brain Barrier (1)
- Blut (1)
- Blutkontakt (1)
- Blutzucker (1)
- Bodenbakterien (1)
- Bola-Amphiphil (1)
- Bond cleavage (1)
- Bond length alternation in aromatics (1)
- Bone Morphogenetic Protein (1)
- Bor-Carbonylkomplexe (1)
- Bor-dotiert (1)
- Bor-Übergangsmetallverbindungen (1)
- Boracumulen (1)
- Boracumulene (1)
- Boracyclopropene (1)
- Boraheterocycles (1)
- Boranes (1)
- Borate (1)
- Borido (1)
- Boridokomplexe (1)
- Borierung (1)
- Borkomplexe (1)
- Borol (1)
- Boryl (1)
- Boryl Anion (1)
- Borylanionen (1)
- Borylation (1)
- Borylcomplexes (1)
- Borylene complexes (1)
- Borylenecomplexes (1)
- Borylentransfer (1)
- Borylenübergangsmetallkomplexe (1)
- Borylkomplex (1)
- Borylkomplexe (1)
- Brain-derived neurotrophic factor (1)
- Brechzahl (1)
- Bronchialasthma (1)
- Brushite (1)
- Brustdrüse (1)
- Brückenbildung (1)
- Burkholderia pseudomallei Mip (1)
- Butadien (1)
- Butatrien-Analogon (1)
- Butyrylcholinesterase (1)
- B−H activation (1)
- C-3-substituiert (1)
- C-3-substituted (1)
- C-C- Activation (1)
- C-C-Aktivierung (1)
- C-C-Bonding (1)
- C-C-Verknüpfung (1)
- C-F bond activation (1)
- C-F-Aktivierung (1)
- C-verknüpfte Naphthylisochinolin-Alkaloide (1)
- C/Si Bioisosterie (1)
- C/Si bioisosteric investigations (1)
- C/Si bioisosterism (1)
- C/Si-Bioisosterie (1)
- C/Si-Switch (1)
- CAAC (1)
- CAD detection (1)
- CARS (1)
- CC2 (1)
- CCL2 (MCP-1) (1)
- CCl4-induzierte Leberfibrose (1)
- CD-Spectra (1)
- CD-Spektren (1)
- CD163 (1)
- CDT1 (1)
- CE (1)
- CE Proteaes (1)
- CE-oTOF-MS (1)
- CIP2A (1)
- CLEC-2 ITAM (1)
- CLIO (1)
- CNS (1)
- CO sensing (1)
- CORM (1)
- COSMOtherm (1)
- CPP Peptide (1)
- CPP-peptide (1)
- CTGF (1)
- CVD Synthese (1)
- CXCL8 (IL-8) (1)
- CYP19 (1)
- CYP51 (1)
- CYR61 (1)
- CZE (1)
- Caco-2 (1)
- Caging (1)
- Calciumantagonist (1)
- Calciumhydroxid (1)
- Calciumphosphat (1)
- Calciumphosphatzemente (1)
- Calculation (1)
- Calix[4]aren (1)
- Calluskultur (1)
- Calmodulin (1)
- Campylobacter jejuni (1)
- Cappuccino (1)
- Carbachol-induced drinking (1)
- Carbanion (1)
- Carbazole (1)
- Carben-Komplexe (1)
- Carbene insertion (1)
- Carbenkomplexe (1)
- Carbocistein (1)
- Carbokationen (1)
- Carbolin <beta-> (1)
- Carbon Additives (1)
- Carbon Monoxide (1)
- Carbon additives (1)
- Carbon surface chemistry (1)
- Carbonsäure (1)
- Carbonsäuren (1)
- Carbonyl- (1)
- Carbonylverbindung (1)
- Carbonylverbindungen (1)
- Carboran (1)
- Carboxylat-Rezeptor (1)
- Carboxylates (1)
- Carcinogenese (1)
- Carcinogenität (1)
- Caretaker gene syndromes (1)
- Caretaker-Gen-Syndrome (1)
- Cascades (1)
- Cassins (1)
- Catechin C-glykoside (1)
- Catechin C-glykosides (1)
- Catechine (1)
- Catecholestrogene (1)
- Catecholmethyltransferase <Catechol-0-Methyltransferase> (1)
- Cell cycle (1)
- Ceramic (1)
- Ceramic polymer composite (1)
- Ceramics (1)
- Cerulenin (1)
- Chain Polymers (1)
- Charged Aerosol Detektion (1)
- Charged aerosol detection (1)
- Charged aerosol detector (CAD) (1)
- Chelat-Liganden (1)
- Chelatbildner (1)
- Chemical Synthesis (1)
- Chemical modification (1)
- Chemical modification of biopolymers (1)
- Chemical stability (1)
- Chemie Methoden (1)
- Chemieunterricht (1)
- Chemische Biologie (1)
- Chemische Reaktion (1)
- Chemometric (1)
- Chemometrics (1)
- Chewing Gum (1)
- Chinazoline (1)
- Chinazoliniumverbindungen (1)
- Chinazolinone (1)
- Chinodimethane (1)
- Chinolinderivate (1)
- Chinolizinderivate (1)
- Chinoliziniumsalze (1)
- Chinolonderivate (1)
- Chinolonderivate <2-> (1)
- Chinolone (1)
- Chinon-oxidoreduktase (1)
- Chiral secondary and teriary phosphines (1)
- Chirale Trennung (1)
- Chirale sekundäre und tertiäre Phosphane (1)
- Chlamydia trachomatis (1)
- Chloral (1)
- Chloral (Trichloracetaldehyd) (1)
- Chlorin (1)
- Chlorophyllderivate (1)
- Chloroquin (1)
- Cholinesterase (1)
- Chondrogenic differentiation (1)
- Chondrozyten (1)
- Chromophore (1)
- Circular Dichroismus (1)
- Circular dichroism spectroscopy (1)
- Cisaprid (1)
- Cisapride (1)
- Citrato(2-)-03 (1)
- Clonidin (1)
- Clopidogrel (1)
- Clostridium botulin (1)
- Clotrimazol (1)
- Clusteranalyse (1)
- Clustermodell (1)
- Coahuila (1)
- Codon (1)
- Coffea arabica (1)
- Coffein (1)
- Coherent 2D spectroscopy (1)
- Coherent Multidimensional Spectroscopy (1)
- Coherent control (1)
- Colloidal Stability (1)
- Colloidal stability (1)
- Colon-Targeting (1)
- Combinatorial Method Development (1)
- Commercial preparations (1)
- Computational drug-design (1)
- Computerchemie (1)
- Confocal Raman-Spectroscopy (1)
- Connective Tissue Growth Factor (1)
- Contaminants (1)
- Coordination (1)
- Coordination Polymer (1)
- Coordination Polymers (1)
- Cope-Umlagerung (1)
- Copper (1)
- Copper Polysulfides (1)
- Copper catalysis (1)
- Copper-Aluminum-Oxide (1)
- Copper-Chromium-Oxide (1)
- Corannulene (1)
- Corona charged aerosol detector (1)
- Coronavirus (1)
- Cortical Actin Cytoskeleton (1)
- Coupled-Cluster (1)
- Coupled-Cluster Theory (1)
- Coupled-Cluster-Theorie (1)
- Cryoelectron Microscopy (1)
- Cryoelectron microscopy (1)
- Crystal structure of MTR1 (1)
- CuAAC (1)
- Curtin / Hammett Verhalten (1)
- Curtin / Hammett-Behavior (1)
- Cyaninfarbstoff (1)
- Cyanoborate (1)
- Cyclic Allenes (1)
- Cyclische Allene (1)
- Cyclische Verbindungen (1)
- Cyclization (1)
- Cyclo-AMP (1)
- Cycload (1)
- Cycloalkene (1)
- Cycloallene dimerization (1)
- Cyclobuta[c}pyridines (1)
- Cyclobutylcarbinyl sulfonates (1)
- Cyclohept-3-en-1-ols (1)
- Cyclooctine (1)
- Cyclooctyne (1)
- Cyclooxygenase (1)
- Cyclopenta[c]pyran-3(5H)-on (1)
- Cyclopenta[c]pyran-3(7H)-on (1)
- Cyclopenta[c]pyrane (1)
- Cyclopentadienylgruppe (1)
- Cyclopentapyrane (1)
- Cyclopenten-4-yl-Kation (1)
- Cyclophan (1)
- Cyclopropanetetracarbonitrile derivatives (1)
- Cymantren (1)
- Cyperus (1)
- Cystein (1)
- Cystein-Protease (1)
- Cystein-Proteasen (1)
- Cytochrom P450 (1)
- Cytochrom-P450-Enzym (1)
- Cytochrom-P450-Enzyme, Carboxylesterasen, Glutathion-S-Transferasen (1)
- Cytochromperoxidase (1)
- Cytotoxiticity-Assay (1)
- DAF-2 (1)
- DFT and ab-initio calculations (1)
- DFT- und ab-initio-Rechnungen (1)
- DFT-Berechnungen (1)
- DHX30 (1)
- DKH (1)
- DKS-RI (1)
- DKS2-RI (1)
- DNA base excision repair (1)
- DNA catalyst (1)
- DNA fingerprinting (1)
- DNA recognition (1)
- DNA sensing (1)
- DNA-Basen (1)
- DNA-Reparatur (1)
- DNA-Replication (1)
- DNA-based nanostructures (1)
- DNA-encoded library synthesis (1)
- DNA-processing enzymes (1)
- DNA-tagged amines (1)
- DNA/RNA binding (1)
- DNA/RNA sensors (1)
- DNS-Chip (1)
- DOSY-NMR (1)
- DPP III enzyme (1)
- DPP IV (1)
- DSC (1)
- DSMA1 (1)
- DUB (1)
- Daidzein (1)
- Damage (1)
- Daptomycin (1)
- Datenauswertung (1)
- Deagglomerierung (1)
- Decarbonylierung (1)
- Dectin-1 (1)
- Deep Eutectics (1)
- Degradation (1)
- Dehydrogenative Coupling (1)
- Dehydrogenative Kupplung (1)
- Dehydrokupplung (1)
- Delafossit (1)
- Delafossite (1)
- Demethylierung (1)
- Dendrimer (1)
- Dendrimere (1)
- Dendrimers (1)
- Density functional theory (1)
- Dentaladhäsiv (1)
- Deoxyhypusinhydroxylase (1)
- Derivatization (1)
- Desorption (1)
- Deubiquitinasen (1)
- Dextrane (1)
- Di-Pi-Methan-Umlagerung (1)
- Di-pi-methane-rearrangement (1)
- Diagnostik (1)
- Dialkyldithiocarbamatodiphenylphosphanes (1)
- Diarylethen (1)
- Diarylethene (1)
- Diarylethylene (1)
- Diastereoselectivity (1)
- Diastereoselektivität (1)
- Diazabicyclononan (1)
- Diazabicyclononane (1)
- Diazabicyclononanone (1)
- Dibenzobarrelene (1)
- Diboran(4)yl-Platin-Komplex (1)
- Diboran(6)-Verbindung (1)
- Diboration (1)
- Diborierung (1)
- Diborin (1)
- Diborylalkene (1)
- Diboryne (1)
- Dicarbonyl (1)
- Dichtebestimmung in Theorie und Experiment (1)
- Dichtefunktional (1)
- Dichtefunktionalrechnungen (1)
- Dichtefunktionaltheorie (1)
- Dichtefunktionsformalismus (1)
- Dichtegewichtete Bildgebung (1)
- Dichtegradientenultrazentrifugation (1)
- Dickdarm (1)
- Dickdarmkrebs (1)
- Dictyota (1)
- Dictyotaceae (1)
- Dicyclohexylcarbodiimid (1)
- Dielektrizitätszahl (1)
- Diels-Alder reaction (1)
- Diels-Alder-Reaktion (1)
- Diels–Alder reaction (1)
- Differential Shannon Entropy (1)
- Differentielle Genexpression (1)
- Diffusionskonstante (1)
- Digital Light Processing (1)
- Digitale Signalverarbeitung (1)
- Dihydroborane (1)
- Dihydroxynaphthaline (1)
- Diketopyrrolopyrrol (1)
- Dilation (1)
- Dilatometer (1)
- Dimensionsgenauigkeit (1)
- Dimere Tacrinverbindungen (1)
- Dimermethode (1)
- Dioncophyllaceae leaves (1)
- Dioxetan (1)
- Dipeptide (1)
- Diphosphonate (1)
- Dipol <1,3-> (1)
- Dipol-Dipol-Wechselwir (1)
- Dipolmoment (1)
- Dipyridamol (1)
- Diradicals (1)
- Diradikalen (1)
- Direkttablettierung (1)
- Disilanderivate (1)
- Dissertation (1)
- Dissipatives System (1)
- Dissoziative Photoionisation (1)
- Docking protein (1)
- Dockingstudien (1)
- Doering-Moore-Skattebol-Reaction (1)
- Doering-Moore-Skattebol-Reaktion (1)
- Donor (1)
- Donor-Photosensibilisator-Akzeptor Triade (1)
- Donor-stabilisiertes Silylen (1)
- Donorgruppe (1)
- Donor−acceptor dyads (1)
- Dopaminrezeptor (1)
- Doppler-Verbreiterung (1)
- Dosimeter (1)
- Dosis (1)
- Dosislinearität (1)
- Dotierung (1)
- Dreifachbindung (1)
- Dreistoffgemisch (1)
- Dreizähniger Ligand (1)
- Druck (1)
- Drug Delivery (1)
- Drug delivery platforms (1)
- Drug form selection (1)
- Drug-Polymer Interactions (1)
- Dual setting system (1)
- Duftstoffe (1)
- Dyes/pigments (1)
- Dynamic charge acceptance (1)
- Dünnfilm (1)
- Dünnschichtchromatographie (1)
- EA.hy 926 (1)
- ECD-Spektroskopie (1)
- EDA-NOCV (1)
- EDC-NHS chemistry (1)
- EGA-FTIR (1)
- ELF (1)
- ERF (1)
- ESI-MS (1)
- Echium spp. (1)
- Effluxpumpen (1)
- Einschlusskomplex (1)
- Einschlusskomplexe (1)
- Einschlussverbindungen (1)
- Einzelmolekülspektroskopie (1)
- Einzelstrang-DNA (1)
- Eisenorganische Verbindungen (1)
- Eisenoxid-Nanopartikel (1)
- Elastizität (1)
- Elastizitätsmodul (1)
- Electrochemical and Mechanical Interplay (1)
- Electrodynamic trap (1)
- Electron Density (1)
- Electron Transfer (1)
- Electron demand in ditosylates (1)
- Electron density (1)
- Electron transfer (1)
- Electronic Circular Dichroism (1)
- Electronic spectroscopy (1)
- Elektrische Leitfähigkeit (1)
- Elektrodynamische Falle (1)
- Elektron-Transfer (1)
- Elektronendichtebestimmung (1)
- Elektronenlokalisierung (1)
- Elektronenspektroskopie (1)
- Elektronenstrahlmikrosonde (1)
- Elektronische Anregung (1)
- Elektronische Spektroskopie (1)
- Elektronischer Circulardichroismus (1)
- Elektrorotation (1)
- Elektrorotationsmessung (1)
- Elektrospinnen (1)
- Element-Element-Activation (1)
- Element-Element-Aktivierung (1)
- Elongation (1)
- Elongin-C Protein-Protein Interaktion (1)
- Elongin-C protein-protein interaction (1)
- Embedded Clustermodell (1)
- Emulsion (1)
- En-Reaktion (1)
- En-Synthese (1)
- Enantiodifferenzierung (1)
- Enantiomere (1)
- Encarbamat (1)
- Encephalitis (1)
- Endothel (1)
- Endothelial Cell-Cell Contacts (1)
- Endotheliale Zell-Zell-Kontakte (1)
- Ene Reaction (1)
- Enecarbamate (1)
- Energie-Transfer (1)
- Energiehyperfläche (1)
- Energielandschaft (1)
- Energietransfer <Mikrophysik> (1)
- Energy Transfer (1)
- Enhancer (1)
- Enolether (1)
- Enoyl-acyl-carrier-protein-Reductase (1)
- Enoyl-acyl-carrier-protein-Reductase <Enoyl-[acyl-carrier-protein]-Reductase> (1)
- Enoyl-acyl-carrier-protein-Reductase<Enoyl-[acyl-carrier-protein]-Reductase> (1)
- Entladung (1)
- Enzym (1)
- Enzym Assays (1)
- Enzym-Screening (1)
- Enzymatische Aktivität (1)
- Enzyme (1)
- Enzyme Assays (1)
- Enzymes (1)
- Eotaxin (1)
- Episulfid (1)
- Epoxide (1)
- Erdalkalimetalle (1)
- Erdbeeren (1)
- Erdmandel (1)
- Eriodictyon californicum (1)
- Erregbarkeit (1)
- Eruca sativa Mill. (1)
- Erythromycin (1)
- Esien (1)
- EspI (1)
- Ester (1)
- Esterasen (1)
- Estradiolkonjugate (1)
- Estrogens (1)
- Ethambutol (1)
- Ethyl (1)
- Ethylen- (1)
- Ethylradikal (1)
- Eukaryoten (1)
- Euphorbiaceae (1)
- European Pharmacopoeia (1)
- Europäsches Arzneibuch (1)
- Ex vivo (1)
- Ex-Chiral-Pool Synthese (1)
- Excipient selection (1)
- Excited states (1)
- Exciton (1)
- Exciton Coupling (1)
- Exciton coupling (1)
- Exciton–exciton annihilation (1)
- Experimente (1)
- Expiry date (1)
- Exziton-Exziton-Anihillierung (1)
- Exzitonen (1)
- Exzitonentransport (1)
- Exzitotoxizität (1)
- FGF (1)
- FGF-2 (1)
- FH2 (1)
- FKBP (1)
- FL spectroscopy (1)
- FLEXS (1)
- FRET-Assay (1)
- FRET-assay (1)
- FSME (1)
- FT-Raman (1)
- FT-Raman spectroscopy (1)
- FT-Raman-Spektroskopie (1)
- Fachdidaktik (1)
- FadA5 (1)
- Falle (1)
- Fanconi Anämie (FA) (1)
- Fanconi anemia (FA) (1)
- Fanconi-Anämie (1)
- Farbstoffe (1)
- Farbstoffe/Pigmente (1)
- Faser (1)
- Fasersonde (1)
- Faserverstärkung (1)
- Fatty acids (1)
- Feeding experiment (1)
- Feigenkaktus (1)
- Fel (1)
- Feldeffekttransistor (1)
- Femto-chemistry (1)
- Femtochemie (1)
- Femtosecond (1)
- Femtosekunden (1)
- Femtosekunden Spektroskopie (1)
- Femtosekunden zeitaufgelöste Spektroskopie (1)
- Femtosekunden-Spektroskopie (1)
- Fentons Reagenz (1)
- Fermentation (1)
- Ferrio-silanole (1)
- Ferrio-silanols (1)
- Ferrocenderivate (1)
- Ferrocenophane (1)
- Ferroelektrikum (1)
- Ferroelektrizität (1)
- Fertigarzneimittel (1)
- Fest-Flüssig-Extraktion (1)
- Festigkeit (1)
- Festkörper (1)
- Festkörper-NMR (1)
- Festkörper-NMR-Spektroskopie (1)
- Festphasenextraktion (1)
- Fett (1)
- Fettabbau (1)
- Fettgewebe (1)
- Fettkennzahlen (1)
- Fettsäureabbau (1)
- Fettsäurebiosynthese (1)
- Fettsäuren (1)
- Fettsäuresynthese-II (1)
- Feuchtemessung (1)
- Feuchtigkeitsmessung (1)
- Feuchtigkeitssensor (1)
- Fibrin (1)
- Fibrinogen (1)
- Field effect transistor (1)
- Finite-Elemente-Methode (1)
- Fische (1)
- Flammschutzmittel (1)
- Flavonglykoside (1)
- Flavoniden (1)
- Flavonoids (1)
- Flavonoinds (1)
- Flavor (1)
- Flexibilität (1)
- Fluidized bed granulation process (1)
- Fluor (1)
- Fluor-19 (1)
- Fluor-19-NMR-Spektroskopie (1)
- Fluorchinolone (1)
- Fluorescence Upconversion (1)
- Fluorescence and Crosslinking (1)
- Fluoreszenz Aufkonversion (1)
- Fluoreszenz-Assay (1)
- Fluoreszenzassay (1)
- Fluoreszenzkorrelationsspektroskopie (1)
- Fluoreszenzliganden (1)
- Fluoreszenzlöschung (1)
- Fluoreszenzmarkierung (1)
- Fluoreszenzmikroskopie (1)
- Fluoreszenzpolarisation (1)
- Fluoreszenzschalter (1)
- Fluoreszenzsolvatochromie (1)
- Fluoreszenzsonde (1)
- Fluoreszenzspektroskopie (1)
- Fluoreszenzverstärkung (1)
- Fluoride (1)
- Fluorides (1)
- Fluorkohlenwasserstoffe (1)
- Fluormarker (1)
- Fluorophore (1)
- Fluorosilicates (1)
- Flux (1)
- Flüssig-Flüssig-Extraktion (1)
- Flüssiger Zustand (1)
- Flüssigkristall (1)
- Flüssigphasenabscheidung (1)
- Foldamer (1)
- Foldamere (1)
- Foliengießen (1)
- Foliengießverfahren (1)
- Formaldehyd (1)
- Formin-2 (1)
- Formin-Proteinfamilie (1)
- Formulation (1)
- Fotochemie (1)
- Fotokatalyse (1)
- Fotolyse (1)
- Four-Wave Mixing (1)
- Fourier-Spektroskopie (1)
- Fragmentscreening (1)
- Fragrances (1)
- Fraktale Dimension (1)
- Free Energy Perturbation (1987 : Princeton, NJ) (1)
- Freeze drying (1)
- Freeze-etching (1)
- Freie Energierechnungen (1)
- Freisetzungskinetik (1)
- Frequenzumsetzung (1)
- Frequenzumwandlung (1)
- Fruchtreife (1)
- Fruchtsaft (1)
- Fulminsäure (1)
- Fumonisin B1 (1)
- Fumonisins (1)
- Functional hydrophilic polymers (1)
- Functional properties (1)
- Functionalisation (1)
- Fungi (1)
- Fungizid (1)
- Funktionalisierung von elektrogesponnenen Fasern (1)
- Funktionelle Monomere (1)
- Funktionelle Polymere (1)
- Funktionsgel (1)
- Furan (1)
- Furanderivate (1)
- Furanon (1)
- Furanone (1)
- Förster coupling (1)
- Förster-Kopplung (1)
- G Protein-coupled receptor (1)
- G protein-coupled receptor (1)
- G-Protein gekoppelte Rezeptor (1)
- G-Protein gekoppelte Rezeptoren (1)
- G-protein coupled receptor (1)
- G-protein-coupled receptor (1)
- GABA-Rezeptor-Agonist (1)
- GABAB (1)
- GABA\(_{B}\) (1)
- GC-MS-SCD (1)
- GRK2 (1)
- Gaborochinone A und B (1)
- Gaboroquinone A und B (1)
- Galectine (1)
- Galle (1)
- Galle <Sekret> (1)
- Gallensalze (1)
- Gallensäuren (1)
- Gallium (1)
- Ganglia (rat) (1)
- Gartenrauke (1)
- Gas chromatography (1)
- Gaschromatographie (1)
- Gasdiffusionselektrode (1)
- Gassensor (1)
- Gefriertrocknung (1)
- Gefäßentwicklung (1)
- Gefüge (1)
- Gefügeentwicklung (1)
- Gehaltsbestimmung (1)
- Gelpunkt (1)
- Geminin (1)
- Gen notch (1)
- Genetik (1)
- Genotoxizität (1)
- Genotyp (1)
- Gentransfer (1)
- Gerichtete Erstarrung (1)
- Germane (1)
- Germaniumkomplexe (1)
- Germylenes (1)
- Geschwindigkeit (1)
- Gespannte Ringe (1)
- Gespannte Verbindungen (1)
- Gesundheitsberatung (1)
- Gewebespende (1)
- Gewebespiegel (1)
- Gewinnung und Funktionale Analyse von Wirkstoffen gegen Infektionskrankheiten (1)
- Gibbs activation energy (1)
- Gitterleerstelle (1)
- Glaslot (1)
- Glass-Ceramic (1)
- Glimmer (1)
- Glucagon (1)
- Glucocorticoids (1)
- Glucosinolate (1)
- Glutamate (1)
- Glutamatrezeptoren (1)
- Glycinrezeptor (1)
- Glycosyltransferase (1)
- Glykoside (1)
- Gold Nanoparticles (1)
- Gold Nanopartikel (1)
- Gold- und Silbernanopartikel (1)
- Gold-Nanoparticles (1)
- Goldbrasse (1)
- Gradient boosted trees (GBT) (1)
- Grenzflächenreaktion (1)
- Group13 (1)
- Grundzustand (1)
- Gruppe13 (1)
- Grüner Kaffee (1)
- Grünnoten (1)
- Guanfacin (1)
- Guanidinium Cations (1)
- Guanidiniumverbindungen (1)
- Guanin (1)
- Guanylatcyclase (1)
- Guillain-Barr'e-Syndrom (1)
- Guillain-Barré Syndrom (1)
- Guillain-Barré syndrome (1)
- Guinea-pig uterus (1)
- Gyrasehemmer (1)
- Gärungsalkohole (1)
- H-Aggregate (1)
- H-bonds (1)
- HCN channel (1)
- HCN-Kanal (1)
- HDAC (1)
- HDMF (1)
- HFC-tensor (1)
- HFC245fa (1)
- HIC (1)
- HILIC (1)
- HPLC-CD (1)
- HPLC-CD coupling (1)
- HPLC-CD-Kopplung (1)
- HPLC-CD-NMR (1)
- HPLC-ECD-Kopplung (1)
- HPLC-ECD-coupling (1)
- HPLC-ESI-MS-MS-Analytik (1)
- HPLC-ESI-MS-MS-analysis (1)
- HPLC-MS/MS (1)
- HPLC-NMR coupling (1)
- HPLC-NMR-Kopplung (1)
- HPLC/UV, HPLC/fluorescence, LC/MS/MS analysis (1)
- HPLC/UV-, HPLC/Fluoreszenz-, LC/MS/MS-Analyse (1)
- HSAB principle (1)
- HSF-1 (1)
- HSP70 (1)
- HT-29 colon carcinoma cells (1)
- Halbsandwich-Komplexe (1)
- Halbsandwichkomplexe (1)
- Halfsandwich-complexes (1)
- Halfsandwich-type-complexes (1)
- Halogene (1)
- Halogenierte {CB11}-Cluster (1)
- Halonium ions (1)
- Haloperidol (1)
- Hamilton-Rezeptor (1)
- Haptik (1)
- Hartree-Fock-Methode (1)
- Hauptbindungsdeterminante (1)
- Hauptgruppen-Element-Chemie (1)
- Hausner-Faktor (1)
- Haut Baleichung (1)
- Haut Bleichung (1)
- HeLa-Zelle (1)
- Heatshock Proteins (1)
- Heck-Reaktion (1)
- Hefeartige Pilze (1)
- Helicen (1)
- Heparansulfat (1)
- Hepatitis (1)
- Hepatitis-B-Virus (1)
- Hepatitis-C-Virus (1)
- Herkunft (1)
- Herkunftsnachweis (1)
- Herz (1)
- Herzfrequenz (1)
- Hess theorem (1)
- Hess'scher Satz (1)
- Hetereoelement (1)
- Heteroaggregate (1)
- Heteroaggregates (1)
- Heteroaromaten (1)
- Heteroatomare Verbindungen (1)
- Heterochromatin Protein 1 (1)
- Heterocyclische Carbene-N (1)
- Heterocyclische Verbindungen (1)
- Heterosiloxane (1)
- Heterosiloxanes (1)
- Heterozyklisches Carbene-N (1)
- Hexaarylbenzole (1)
- Hexadehydro-Diels-Alder (1)
- Hexahydro-difenidol (1)
- Hexahydro-difenidol analogues (1)
- Hexahydro-procyclidine (1)
- Hexbutinol (1)
- High-performance liquid chromatography (1)
- High-performance liquid chromatography (HPLC) (1)
- Higher-coordinate Compounds (1)
- Higher-order Transient Absorption Spectroscopy (1)
- Highercoodination (1)
- Hirnzelle (1)
- Histon-Deacetylase (1)
- Hitzeschock Proteine (1)
- Hitzeschocktranskriptionsfaktor (1)
- Hochtemperaturbrennstoffzelle (1)
- Hohe Harmonische (1)
- Hohe Transluzenz (1)
- Hohlkapseln (1)
- Homo Diels-Alder reactions (1)
- Homoaromaticity in carbanions (1)
- Homobenzvalene (1)
- Honig (1)
- Host-Guest Interaction (1)
- Hsp70 (1)
- Human (1)
- Humangenetik (1)
- Humanserum (1)
- Hyaliner Gelenkknorpel (1)
- Hybrid-Molecules (1)
- Hybride (1)
- Hybridliganden (1)
- Hybridmaterial (1)
- Hybridwerkstoff (1)
- Hydroarylation (1)
- Hydroboration (1)
- Hydroborierung (1)
- Hydrodefluorierung (1)
- Hydrogen bond (1)
- Hydrogen-Bond (1)
- Hydroperoxide (1)
- Hydrophosphination (1)
- Hydroxycarbonsäureester (1)
- Hydroxylradikal (1)
- Hyperfeinkopplungstensor (1)
- Hyperfine coupling constants (1)
- Hyperfinekopplungskonstante (1)
- Hyperkonjugation (1)
- Hypervalenz (1)
- Hypoxanthin-Guanin-Phosphoribosyl-Transferase (1)
- Höherkoordinierte Verbdinungen (1)
- Hülsenfrüchte (1)
- I1 Imidazolin Bindungsstelle (1)
- I1 imidazoline binding site (1)
- ICD (1)
- IGF-1 (1)
- IGF-I (1)
- IGHMBP2 (1)
- II-VI Halbleiter (1)
- II-VI-Halbleiter-Nanopartikel (1)
- II-VI-semiconductor nanoparticles (1)
- IL-4 (1)
- IR (1)
- IRMS (1)
- ISRS (1)
- Ibuprofen (1)
- Ileum; Atrium (1)
- Imidates (1)
- Imido (1)
- Imido ligands (1)
- Imidoyl halides (1)
- Iminoboran (1)
- Iminoborane (1)
- Iminoborylkomplex (1)
- Iminoborylkomplexe (1)
- Iminogruppe (1)
- Immobilisierter Ligand (1)
- Immunisierung (1)
- Immunmodulation (1)
- Immunohistologie (1)
- Immunpräzipitationen (1)
- Immunreaktion (1)
- Impedanzspektroskopie (1)
- Impfung (1)
- Implantate (1)
- Implantatwerkstoff (1)
- Importance of hydrophilic block in amphiphiles (1)
- Impurity Profile (1)
- In vitro rat (1)
- In vitro testing (1)
- In-vitro-Assays (1)
- Indenyl (1)
- Indenyl-Ruthenium-Komplexe (1)
- Indenylgruppe (1)
- Indikator (1)
- Indirect and direct contributions to A<sub>iso</sub> (1)
- Indolderivate (1)
- Influence of excitation classes (1)
- Infrarotspektroskopie (1)
- Infusionslösungen (1)
- Inhalationsmittel (1)
- Inhibitoren der Acetylcholinesterase (1)
- Inhibitorpeptide (1)
- Initiation der DNA Replikation (1)
- Initiationsproteine der Maus (1)
- Inkjet (1)
- Inkjet 3D Printing (1)
- Inklusives Setting (1)
- Inorganic-organic polymer (1)
- Insertionsreaktionen (1)
- Insulin (1)
- Insulin-like Growth Factor (1)
- Insulin-like growth factor-I (1)
- Integrasen (1)
- Integrine (1)
- Interkalation (1)
- Interleukin (1)
- Interleukin 13 (1)
- Interleukin 5 (1)
- Interleukin-4 (1)
- Interleukin-5 (1)
- Intervalenzladungstransfer (1)
- Intervalenzverbindungen (1)
- Iod (1)
- Iodine (1)
- Iodmolekül (1)
- Ion Pairs (1)
- Ionenchromatographie (1)
- Ionenkanal (1)
- Ionenpaarchromatographie (1)
- Ionentauscher (1)
- Ionexchange (1)
- Ionic Liquid (1)
- Ionisationsenergie (1)
- Ipratropiumbromid (1)
- Iridium bis(phosphinite) pincer complexes (1)
- Iron Oxide Nanoparticles (1)
- Islets of Langerhans (rat) (1)
- Isochinolinalkaloide (1)
- Isocyanate (1)
- Isoenzym (1)
- Isoindoline (1)
- Isolation (1)
- Isolierung (1)
- Isomer (1)
- Isonitril- (1)
- Isoprostaglandin (1)
- Isoquinolines (1)
- Isosterie (1)
- Isotopendiskriminierung (1)
- Isotopenhäufigkeit (1)
- Isotopenmarkierung (1)
- Isotopenmassenspektroskopie (1)
- Isotopieeffekt (1)
- Isotpe ratio mass spectrometry (1)
- J-Aggregat (1)
- J-aggregate (1)
- JAK inhibitor (1)
- Janus Head Ligand (1)
- Januskopfligand (1)
- Jugend (1)
- Jugendliche (1)
- J‐aggregates (1)
- KIND (1)
- Kaiser test (1)
- Kaktusfeige (1)
- Kaliumkanal (1)
- Kaltgepresstes Öl (1)
- Kammerwasser (1)
- Kaninchen (1)
- Kannenpflanze (1)
- Kanzerogenese (1)
- Kappa (1)
- Karyotyp (1)
- Kaskaden (1)
- Kathode (1)
- Kaugummi (1)
- Keatit (1)
- Keimbildner (1)
- Keramikfaser (1)
- Kern-Schale-Partikel (1)
- Kernrezeptor (1)
- Kernspinrelaxation (1)
- Kernspintomografie (1)
- Ketene (1)
- Ketoacyl-ACP-Synthase <beta> (1)
- Ketone (1)
- Ketosulfon (1)
- Kidney (perfused (1)
- Kidneys (1)
- Kind (1)
- Kinder (1)
- Kinetic field (1)
- Kinetics (1)
- Klinische Pharmazie (1)
- Klinische Studie (1)
- Kniegelenk (1)
- Knipholon (1)
- Knipholone (1)
- Knochen-Morphogenese-Proteine (1)
- Knochenpenetration (1)
- Knochenzemente (1)
- Knock out (1)
- Knock-out Maus (1)
- Knorpel (1)
- Kobaltkomplex (1)
- Kofaktorbindung (1)
- Kohlenhydrate (1)
- Kohlenmonoxid (1)
- Kohlenstoff-14 (1)
- Kohlenstoffadditive (1)
- Kohlenwasserstoffe (1)
- Kohn-Sham Orbitale (1)
- Kohn-Sham Orbitals (1)
- Kohärente 2D Spektroskopie (1)
- Kohärente Kontrolle (1)
- Kohärente Optik (1)
- Kohäsion (1)
- Kokristallisation (1)
- Kolloid (1)
- Kombinatorische Chemie (1)
- Komplexierung (1)
- Komposit (1)
- Komposit <Zahnmedizin> (1)
- Komposite (1)
- Kompositschicht (1)
- Kondensation (1)
- Kondensiertes Ringsystem (1)
- Konfiguration (1)
- Konfiguration <Chemie> (1)
- Konfokale Mikroskopie (1)
- Konfokale Raman-Spektroskopie (1)
- Konformationsanalyse (1)
- Konformeren (1)
- Konjugiertes System (1)
- Konservierung (1)
- Kontrollierte Wirkstofffreisetzung (1)
- Kontrolltheorie (1)
- Konzentrat (1)
- Konzentrationssprungmethode (1)
- Kooperativität (1)
- Koordination (1)
- Koordinationspolymer (1)
- Koordinativ ungesättigte Verbindung (1)
- Koronarperfusion (1)
- Korrosion (1)
- Korrosionsempfindliche (1)
- Korund (1)
- Kosmochemie (1)
- Kovalente Inhibitoren (1)
- Kraftfeld (1)
- Kraftfeld-Rechnung (1)
- Kraftmikroskopie (1)
- Kreatinin (1)
- Krebsforschung (1)
- Kreuzkupplungsreaktion (1)
- Kriechen (1)
- Kriechverhalten (1)
- Kristalloberfläche (1)
- Kulturgut (1)
- Kunststoff (1)
- Kupfer (1)
- Kupfer katalyse (1)
- Kupfer- und Eisen-dotierten Glas-Systemen (1)
- Kupfer-Aluminium-Oxid (1)
- Kupfer-Chrom-Oxid (1)
- Kupffer-Sternzelle (1)
- Käfig-Rekombination (1)
- Kühlkörper (1)
- LARP4B (1)
- LARP7 (1)
- LC-CD (1)
- LC-HRESIMS (1)
- LC3 lipidation (1)
- LMICS (1)
- LPA (1)
- Lactamantibiotikum <beta-> (1)
- Lacton concept (1)
- Lacton-Konzept (1)
- Lactone (1)
- Lactone conformations (1)
- Lactose (1)
- Ladungstransport (1)
- Ladungsträgererzeugung (1)
- Lambda5-Germanate (1)
- Lambda5-organofluorosilicate (1)
- Lambda5Si-Spirosilicate (1)
- Lanthanides (1)
- Lanthanidkomplexe (1)
- Laser (1)
- Laser-Flash (1)
- Laser-Kontrolle (1)
- Laserbeugungsanalyse (1)
- Laserchemie (1)
- Laserinduzierte Fluoreszenz (1)
- Laserspektroskopie (1)
- Latex (1)
- Layer-by-Layer-Verfahren (1)
- Lead-Acid (1)
- Lebensdauer (1)
- Lebensmittel (1)
- Lebensmittelanalyse (1)
- Lebensmittelprodukte (1)
- Lebensmittelzusatzstoffe (1)
- Leberfibrose (1)
- Leerstellen (1)
- Legionella infection (1)
- Legionellen (1)
- Legionelleninfektion (1)
- Legionnaires' Disease (1)
- Legionnaires' disease (1)
- Leitfähige Polymere (1)
- Leitstrukturoptimierung (1)
- Levodopa (1)
- Lewis acidity (1)
- Lewis adduct (1)
- Lewis base (1)
- Lewis bases (1)
- Lewisaddukt (1)
- Licht-Sammel-Komplex (1)
- Lichtsammelsystem (1)
- Lichtstreuung (1)
- Lidocain (1)
- Ligand Displacement (1)
- Ligand-Rezeptor Komplex (1)
- Liganddesign (1)
- Liganden-Design (1)
- Ligandendesign (1)
- Line-shape analysis (1)
- Linezolid (1)
- Lipidmembran (1)
- Liposomen (1)
- Lipoxygenase (1)
- Lippert–Mataga plot (1)
- Lithium (1)
- Lithium-Ion Battery (1)
- Lithium-ion Battery (1)
- Lithiumalkyl (1)
- Lokalisation (1)
- Lokaltherapie (1)
- Long-range coupling constants (1)
- Loperamid (1)
- Low-income Countries (1)
- LpxC inhibitors (1)
- Luftfeuchtigkeit (1)
- Lumineszenzlöschung (1)
- Lungenentzündung (1)
- Lungengewebe (1)
- Lungenkrebs (1)
- Lungenperfusion (1)
- Lymphocytes (1)
- Lymphozyt (1)
- Lyophilisate zum Einnehmen (1)
- Löslichkeitsstudien (1)
- Löslichkeitsverbesserung (1)
- Lösungsmitte (1)
- Lösungsmittel (1)
- Lösungsmitteleffekt (1)
- Lösungsprozess (1)
- M. tuberculosis (1)
- M1 Muscarinic Receptor (1)
- M2 (1)
- M4 (1)
- M4 receptors (1)
- MAO-Hemmer (1)
- MAP-Kinase (1)
- MCM (1)
- MD simulation (1)
- MD simulations (1)
- MD-Simulationen (1)
- MDR (1)
- MEEKC (1)
- MEKC (1)
- MEPE (1)
- METTL8 (1)
- MIBG (1)
- MIP protein (1)
- MIR-Spektroskopie (1)
- MIRAS (1)
- MLLE domain (1)
- MMC (1)
- MOF (1)
- MOFs (1)
- MP-Störungstheorie (1)
- MR contrast agent (1)
- MRCI (1)
- MRSA (1)
- MS (1)
- MTUS1 (1)
- MVA (1)
- MYC (1)
- MYCN (1)
- Macrophage Infectivity Potentiator Protein (1)
- Macrophage infectivity potentiator Protein (1)
- Magnesium (1)
- Magnetfeldeffekt (1)
- Magnetische Resonanz (1)
- Magnetisches Trennverfahren (1)
- Magnetresonanztomographie (1)
- Mahlen (1)
- Maiglöckchen (1)
- Main Group-Element-Chemistry (1)
- Makroarray (1)
- Makrocyclische Verbindungen (1)
- Makrophage (1)
- Malignant melanoma (1)
- Mannich-Reaktion (1)
- Manteltiere (1)
- Map-kinase (1)
- Marine Pilze (1)
- Markierte Verbindungen (1)
- Mars Meteoriten (1)
- Mars Meteorites (1)
- Masernvirus (1)
- Mass spectrometry (1)
- Massenbilanzierung (1)
- Masspectrometry (1)
- Masterkurve (1)
- Materialentwicklung (1)
- Matrix Effekte (1)
- Matrixmetalloproteinase (1)
- Maßhaltigkeit (1)
- McN-A-343 analogs (1)
- Mechanische Eigenschaft (1)
- Mechanistische Studien (1)
- Medaka - Genetransfer - Transient expression - DNA fate - Fish developmental biology (1)
- Medizin (1)
- Megakaryocytes (1)
- Megakaryozyt (1)
- Megakaryozyten (1)
- Mehrkernige Komplexe (1)
- Mehrkomponentengemische (1)
- Mehrphotonen-Spektroskopie (1)
- Mehrphotonenprozess (1)
- Meisenheimer complex (1)
- Melanin (1)
- Melatonin-Analoga (1)
- Melatoninrezeptorliganden (1)
- Melt Electrowriting (1)
- Melt electrowriting (1)
- Membrane Carrier (1)
- Membrantransport (1)
- Merkaptursäuren (1)
- Merocyanine Dye (1)
- Merocyanine dyes (1)
- Mesenchymzelle (1)
- Mesoporous (1)
- Messprozess (1)
- Messung (1)
- Metabolisches Syndrom (1)
- Metabolism (1)
- Metabolismusstudien (1)
- Metabolom (1)
- Metabolomik (1)
- Metabonomix (1)
- Metaheuristik-Suchmethoden (1)
- Metal-Only Lewis Pairs (1)
- Metal-assisted Hydrophosphination (1)
- Metall-Ion (1)
- Metall-Luft-Batterie (1)
- Metallassistierte Hydrophosphinierung (1)
- Metallierte Verbindungen (1)
- Metallkoordination (1)
- Metallmatrix-Verbundwerkstoff (1)
- Metallo-phosphan (1)
- Metallo-silanols (1)
- Metallo-siloxane (1)
- Metalloproteinasen (1)
- Metalloradicals (1)
- Metallorganic (1)
- Metallorganische Gerüstverbindung (1)
- Metathese (1)
- Metformin (1)
- Methoctramine (1)
- Method Validation (1)
- Methodenwerkzeuge (1)
- Methyl(maleato)stibane (1)
- Methyl(phthalato)stibane (1)
- Methylanthranilat (1)
- Methylation (1)
- Methyldiethoxistibane (1)
- Methyllithium (1)
- Methyltransferase Ribozyme MTR1 (1)
- MgAl LDH (1)
- Micellare elektrokinetische Kapillarchromatographie (1)
- Michael addition (1)
- Michael-Addition (1)
- Microarray (1)
- Microbial reduction (1)
- Microcapsules (1)
- Microorganismen (1)
- Midazolam (1)
- Mie Theorie (1)
- Mie Theory (1)
- Migration (1)
- Migration <Technik> (1)
- Migratory aptitudes in carbocations (1)
- Mikrofaser (1)
- Mikrofasern (1)
- Mikrokapseln (1)
- Mikroorganismen (1)
- Mikropartikel (1)
- Mikroporosität (1)
- Mikroskopie (1)
- Mikrosphären (1)
- Mikrostrukturmodellierung (1)
- Milchdrüse (1)
- Mineralokortikoidrezeptor (1)
- Mip (1)
- Mip Inhibitoren (1)
- Mip inhibitor (1)
- Mip-Inhibitor (1)
- Mischbarkeit (1)
- Mischintensität (1)
- Mischkristallkeramik (1)
- Mitochondrial Matrix Protein (1)
- Mitochondrium (1)
- Mitsunobu (1)
- Mizellen (1)
- Mode Selectivity (1)
- Modell (1)
- Modellberechnungen (1)
- Modellbindetasche (1)
- Modellierung (1)
- Modification (1)
- Modified Nucleotides in tRNAs (1)
- Modifikation von Biokeramiken (1)
- Molecular Docking (1)
- Molecular Modelling (1)
- Molecular Recognition (1)
- Molecular Simulation (1)
- Molecular mechanics (1)
- Molecular mechanism (1)
- Molecular modelling (1)
- Molecular probes (1)
- Molekular Modeling (1)
- Molekularbiologie (1)
- Molekulardynamik-Simulationen (1)
- Molekulardynamiksimulationen (1)
- Molekularmechanik (1)
- Molekularstrahl (1)
- Molekül (1)
- Moleküldynamik (1)
- Moleküloptimierung (1)
- Molekülstruktur (1)
- Molekülzu (1)
- Moller-Plesset (1)
- Molnupiravir (1)
- Molnupiravir-Induced RNA Mutagenesis Mechanism (1)
- Molybdenum complexes (1)
- Molybdenum-Sulfur Dioxide Complexes (1)
- Molybdäncarbonyle (1)
- Mometasone furoate (1)
- Mometasonfuroat (1)
- Monoaminoxidase (1)
- Monocyten (1)
- Monodisperse PDMS (1)
- Monodisperses System (1)
- Monoklonaler Antikörper (1)
- Monomere (1)
- Monozyt (1)
- Monozyten (1)
- Monte Carlo Simulation (1)
- Monte Carlo simulation (1)
- Monte-Carlo-Simulation (1)
- Morbus Alzheimer (1)
- Morphologie (1)
- Mosaikgläser (1)
- Mucus (1)
- Mukovisdizose (1)
- Mukoviszidose (1)
- Mulliken-Hush (1)
- Mullit (1)
- Multi Reference (1)
- Multi-Photonen Prozesse (1)
- Multidimensionale Skalierung (1)
- Multifunctionalisability (1)
- Multiheteroatom-Cope-Rearrangement (1)
- Multiheteroatom-Cope-Umlagerungen (1)
- Multikernpartikel (1)
- Multiproteinkomplex (1)
- Multireferenz (1)
- Muscarin Antagonisten (1)
- Muscarinic M1 receptors (1)
- Muscarinic M1 receptors; Muscarinic M2 receptors (1)
- Muscarinic M3 receptor subtypes (1)
- Muscarinic M3selective antagonists (1)
- Muscarinic antagonist (1)
- Muscarinic receptor (1)
- Muscarinic receptor agonists (1)
- Muscarinic receptor antagonists (M 3-selective) (1)
- Muscarinic receptor antagonists (selective) (1)
- Muscarinic receptor subtype (1)
- Muscarinic receptor subtypes; Muscarinic rcceptor agonists (M 1-selective) (1)
- Muscarinie M2 receptors (1)
- Muscarinischer Rezeptor (1)
- Musearinic M4 receptors (1)
- Musearlnie M1 (1)
- Musearlnie aeetyleholine receptor agonists (1)
- Musearlnie aeetyleholine receptor antagonists (1)
- Musearlnie receptor subtypes (1)
- Muskelatrophie (1)
- Mutagenität (1)
- Mykobakterien (1)
- Mykotoxin (1)
- Mykotoxine (1)
- Myositis (1)
- N ligands (1)
- N-Acyl-Ethanolaminphosphate (1)
- N-Demethylierung (1)
- N-Liganden (1)
- N-acetyllactosamine (1)
- N-demethylation (1)
- N-functionalization (1)
- N-heterocyclic carbenes (1)
- N-heterocyclische Carbene (1)
- N-heterozyklisches Carben (1)
- N-ligands (1)
- N-methylpyridinium pyrene (1)
- N6-methyladenosine (1)
- N6-methyladenosine (m6A) (1)
- NACE (1)
- NEDMIAL (1)
- NEXAFS (1)
- NHC complexes (1)
- NHC-Komplexe (1)
- NHC-Phosphiniden Addukte (1)
- NHC-phosphinidene Komplexes (1)
- NHC-stabilisierte Alane (1)
- NHC-stabilisierte Chlorosilane (1)
- NHC-stabilisierte Eisen-Komplexe (1)
- NHC-stabilized alanes (1)
- NHC-stabilized chloro silanes (1)
- NHC-stabilized iron complexes (1)
- NH\(_{3}\) (1)
- NIR (1)
- NIR OLED (1)
- NIR-spectroscopy (1)
- NLO (1)
- NLO properties (1)
- NLO-Eigenschaften (1)
- NLO-Polymere (1)
- NMR Data (1)
- NMR Spin-Spin Coupling Real-Space Functions CED CDD ELF (1)
- NMR Spin-Spin-Kopplung Realraumfunktionen CED CDD ELF (1)
- NMR-Bildgebung (1)
- NMR-Mammographie (1)
- NO (1)
- NOX-Inhibitoren (1)
- NV-Zentren (1)
- Nahfeldoptik (1)
- Nahordnung (1)
- Nanaomaterialien (1)
- Nano (1)
- Nano-Partikel (1)
- Nano-optics (1)
- Nanodiamond (1)
- Nanogels (1)
- Nanohärte (1)
- Nanoimprint (1)
- Nanoindentation (1)
- Nanokomposit (1)
- Nanomaterialien (1)
- Nanomedizin (1)
- Nanoparticles (1)
- Nanopartikelsynthese (1)
- Nanoporöser Stoff (1)
- Nanoprägen (1)
- Nanoröhre (1)
- Nanosilicatpartikel (1)
- Nanostructure (1)
- Nanostrukturen (1)
- Nanotubular coatings (1)
- Nanotubuläre Beschichtungen (1)
- Naphthalimide (1)
- Naphthalinbisimid (1)
- Naphthalinderivate (1)
- Naphthalindiimid (1)
- Naphthaline (1)
- Naphthochinone (1)
- Naphthylisochinolin alkaloide (1)
- Naphthylisochinolin-Alkaloid (1)
- Naphthylisoquinoline alkaloid (1)
- Naphthylisoquinoline alkaloids (1)
- Naphthylisoquinolines (1)
- Naproxen (1)
- Natural product (1)
- Natural product isolation (1)
- Natural products (1)
- Naturidentischer Aromastoff (1)
- Naturstoffisolation (1)
- Neighbouring group participation (1)
- Nepenthaceae (1)
- Nepenthes (1)
- Nephrotoxicity (1)
- Nephrotoxizität (1)
- Nerve growth factor (1)
- Nervenzelle (1)
- Netzbogenlänge (1)
- Neurodevelopmental diseases (1)
- Neuromelanin (1)
- Neuronal survival (1)
- Neuroprotection (1)
- Neuroprotektivum (1)
- Neurotoxine (1)
- Nicht-Störungstheoretisch (1)
- Nicht-adiabatische Dynamik (1)
- Nichtinvasive Diagnostik (1)
- Nichtlineare Dynamik (1)
- Nichtlineare Optik (1)
- Nichtlineare Welle (1)
- Nichtlineares Phänomen (1)
- Nichtlinearität (1)
- Nichtoxidkeramik (1)
- Nichtproteinogene Aminosäuren (1)
- Nichtstarres Molekül (1)
- Nichtsteroidales Antiphlogistikum (1)
- Nickel ComplexCyclic (1)
- Niedere Wirbeltiere (1)
- Nierenfunktion (1)
- Nijmegen Breakage Syndrom (NBS) (1)
- Nijmegen breakage syndrome (NBS) (1)
- Niob (1)
- Niobverbindungen (1)
- Nipah virus (1)
- Nipha-Virus (1)
- Nitrosoaren (1)
- Nitrosoarene (1)
- Non-adiabatic Dynamics (1)
- Non-oxide ceramics (1)
- Nonadiabatic Dynamics (1)
- Nonbonded Interactions (1)
- Nonlinear Dynamics (1)
- Nonlinearity (1)
- Noradrenalin (1)
- Norcaranes (1)
- Norpinanes (1)
- Norrish-Typ-II-Yang-Cyclisierung (1)
- Norrish-Type-II-Yang-cyclization (1)
- Nuclear Receptor (1)
- Nucleinbasen (1)
- Nucleobase Surrogate Incorporation (1)
- Nucleophil (1)
- Nukleinsäure (1)
- Nukleophiles Bor (1)
- Nukleäre Rezeptoren (1)
- Numerische Verfahren (1)
- O-Heterocyclen (1)
- O-heterocycles (1)
- O157 (1)
- OEG chains (1)
- OFETs (1)
- OLED (1)
- OLEDs (1)
- ORL1 (1)
- ORMOCER (1)
- ORMOCER® (1)
- Oberflächen-verstärkte Raman Streuung (SERS) (1)
- Oberflächenbelegung (1)
- Oberflächenmodifizierung (1)
- Oberflächenplasmonresonanz (1)
- Oberflächenrauhigkeit (1)
- Oberflächenstruktur (1)
- Octavalen (1)
- Odorants (1)
- Olefinpolymerisation (1)
- Olfaktorische Analyse (1)
- Oligofructoside (1)
- Oligopeptide (1)
- Oligopyrrole (1)
- Oligopyrrols (1)
- Olivenöl (1)
- Onbead-Enzymscreening (1)
- Ophthalmik (1)
- Opiatrezeptor (1)
- Opioide (1)
- Opioids (1)
- Optical Component (1)
- Optical spectroscopy (1)
- Optimierung (1)
- Optimierungsmethoden (1)
- Optimization methods (1)
- Optische Gradientenfalle (1)
- Oral Fluid (1)
- Orale Antidiabetika (1)
- Orale Applikation (1)
- Orc2 (1)
- Organell (1)
- Organelle (1)
- Organelles (1)
- Organic Field-Effect Transistor (1)
- Organic field-effect transistor (1)
- Organic semiconductors (1)
- Organische Halbleiter (1)
- Organische Sulfide (1)
- Organischer Kationentransporter (1)
- Organisierte Medien (1)
- Organized media (1)
- Organo catalysis (1)
- Organobor (1)
- Organokatalysatoren (1)
- Organokatalyse (1)
- Organometall-Komplexe (1)
- Organometallchemie (1)
- Organometallic Chemistry (1)
- Orientation (1)
- Orientiertes Molekül (1)
- Orientierung (1)
- Origin (1)
- Origin of Recognition (1)
- Ormocer(R) (1)
- Osmium (1)
- Oszillator (1)
- Outflow funnel (1)
- Outlier Detection (1)
- Outlier-Identifizierung (1)
- Oxazolidinon (1)
- Oxazolidinone (1)
- Oxidation states (1)
- Oxidationsstufen (1)
- Oxidationszahl (1)
- Oxidative stress (1)
- Oxo ligands (1)
- Oxo-Anionen-Erkennung (1)
- Oxoboran (1)
- Oxoborane (1)
- Oxoborylkomplex (1)
- Oxoborylkomplexe (1)
- Oxofunktionalisierug (1)
- Oxygen diffusion hardening (1)
- Oxygen evolution reaction (1)
- Oxygen reduction reaction (1)
- Oxygen-Oscillator (1)
- Oxygenierung (1)
- Oxyphencyclimine (1)
- Oxytosis (1)
- P-H-Activation (1)
- P-H-Aktivierung (1)
- P-Liganden (1)
- P-TEFb (1)
- P-ligands (1)
- PA-MBO-System (1)
- PABC1 (1)
- PABP (1)
- PAH formation (1)
- PALS (1)
- PAM2 (1)
- PAM2w (1)
- PAX genes (1)
- PAX-Gene (1)
- PBP pincer palladium complexes (1)
- PCI (1)
- PCL (1)
- PCP signaling (1)
- PCP-Signalweg (1)
- PDGF (1)
- PDGFR (1)
- PDMS-Membranen (1)
- PDMS-membranes (1)
- PDZ-Domäne (1)
- PDZ-domain (1)
- PEG (1)
- PES (1)
- PFC (1)
- PFG-NMR-Spektroskopie (1)
- PI-System (1)
- PI3K/Akt/mTor pathway (1)
- PKC (1)
- PKS (1)
- PLGA (1)
- PPIase (1)
- PPIase-Aktivität (1)
- PROTAC (1)
- PSD-95 (1)
- PVD Beschichtung (1)
- PVD coatings (1)
- PVD-Verfahren (1)
- Pachyrhizus erosus (1)
- Paracetamol (1)
- Paraffin (1)
- Parallele Bildgebung (1)
- Paralleler Prozess (1)
- Parameter <Mathematik> (1)
- Parameter Quality Oil (1)
- Parent Piano-Stool Complex (1)
- Parenteral (1)
- Parkinson's disease (1)
- Partikel (1)
- Pathogenese (1)
- Pathogenität (1)
- Patulin (1)
- Pektine (1)
- Pentacen (1)
- Pentacoordinate silicon (1)
- Pentamethylcyclopentadienderivate (1)
- Pentamethylcyclopentadienylligand (1)
- Pentenol (1)
- Pentenole (1)
- Peptid-Nucleinsäuren (1)
- Peptidbibliothek (1)
- Peptidomimetikum (1)
- Perfusion (1)
- Perizyten (1)
- Peroxyl (1)
- Perugia-Kärpfling (1)
- Perylen-Farbstoffe (1)
- Perylenbisanhydrid (1)
- Perylenbisimide (1)
- Perylenbisimiden (1)
- Perylendianhydrid (1)
- Perylene Bisimide (1)
- Perylene bisimide (1)
- Pescadillo (1)
- Pflanzenextrakt (1)
- Pflanzenextrakte (1)
- Pflanzliche Zellkultur (1)
- Phachyrhizus erosus (1)
- Phaeophyceae (1)
- Pharmacology (1)
- Pharmakogenetik (1)
- Pharmakometrie (1)
- Pharmazeutika (1)
- Pharmazeutische Betreuung (1)
- Pharmazeutische Chemie (1)
- Pharmazie (1)
- Phase separation (1)
- Phase solubility (1)
- Phasenanalyse (1)
- Phenolcarbonsäuren (1)
- Phenylanthrachinone (1)
- Phenylanthrachinones (1)
- Phenylethylamine (1)
- Phenyltetra(acetato)stiborane (1)
- Phosphaneligands (1)
- Phosphanliganden (1)
- Phosphatasen (1)
- Phosphate (1)
- Phosphatentfernung (1)
- Phosphatidylinositol metabolism (1)
- Phosphenium (1)
- Phospheniumkomplexe (1)
- Phosphiniden (1)
- Phosphoantigene (1)
- Phosphoresence (1)
- Phosphorylide (1)
- Phosphorylierung (1)
- Photo-DSC (1)
- Photochemische Reaktion (1)
- Photochrome Verbindungen (1)
- Photodynamics (1)
- Photoelektron (1)
- Photoelektron-Photoion-Koinzidenz (1)
- Photoelektronen-Photoionen-Koinzidenz (1)
- Photoelektronen-Spektroskopie (1)
- Photofragmentspektroskopie (1)
- Photoleitfähigkeit (1)
- Photolithography (1)
- Photolumineszenzspektroskopie (1)
- Photonenecho (1)
- Photonischer Kristall (1)
- Photorefraktiver Effekt (1)
- Photorezeptor (1)
- Photostrukturierung (1)
- Photoswitch (1)
- Photosystem II (1)
- Photovoltaic (1)
- Photovoltaik (1)
- Phyllosilicate (1)
- Physik (1)
- Phytopathogene (1)
- Phytopathogene Pilze (1)
- Phytoöstrogen (1)
- Phytoöstrogene (1)
- Phänotyp (1)
- Pigmente (1)
- Pigmentmuster (1)
- Pigments (1)
- Pilocarpin (1)
- Pilokarpin (1)
- Pilze (1)
- Pinus maritima (1)
- Pipecolinsäurederivate (1)
- Piperedinderivate (1)
- Piperidin (1)
- Pirenzepine (1)
- Pithed rat (1)
- Pitot-Rohr (1)
- Plasmaproteinbindung (1)
- Plasmaproteine (1)
- Plasmodien (1)
- Plasmodium (1)
- Plastide (1)
- Plastiden (1)
- Platelet-derived Growth Factor (1)
- Platelets (1)
- Platinkomplex (1)
- Plazenta (1)
- Plumbylenes (1)
- Plättchen (1)
- Pnictogen reduction (1)
- Poeciliid fish (1)
- Point-of-Care-testing (1)
- Polarisationspulsformung (1)
- Polarisiertes Licht (1)
- Pollen (1)
- Poly(2-oxazine) (1)
- Poly(2-oxazolin) (1)
- Poly(2-oxazoline) (1)
- Poly(2-oxazoline)s and Poly(2-oxazine)s (1)
- Poly(A) binding protein (1)
- Poly(ethylenglykol) (1)
- Poly(glycerol) (1)
- Poly(glycidol)s (1)
- Polyamin (1)
- Polyaminstoffwechsel (1)
- Polyatomare Verbindungen (1)
- Polycaprolacton (1)
- Polycarbazole (1)
- Polychromophores System (1)
- Polydimethylsiloxan (1)
- Polyelektrolyt (1)
- Polyethylene glycol (1)
- Polyethylenglycol (1)
- Polyketides (1)
- Polylactid-co-Glycolid (1)
- Polymer Science (1)
- Polymer-Biokonjugate (1)
- Polymer-drug interaction (1)
- Polymer-peptide-conjugate (1)
- Polymerhalbleiter (1)
- Polymerkomplexe (1)
- Polymerlatex (1)
- Polymerlösung (1)
- Polymers (1)
- Polymethinfarbstoff (1)
- Polymilchsäure (1)
- Polyolefine (1)
- Polyoxazolines (1)
- Polypeptoide (1)
- Polypeptoids (1)
- Polysiloxane (1)
- Polystyrol (1)
- Poorly water soluble drugs (1)
- Poorly water-soluble drug (1)
- Porcine liver esterase (1)
- Porzellan (1)
- Poröse Medien (1)
- Poröser Stoff (1)
- Positronen-Emissions-Tomografie (1)
- Posttranslational modification (1)
- Posttranslationale Änderung (1)
- Potassium channel (1)
- Potentialinduzierte Löschung (1)
- Precision medicine (1)
- Predissociation (1)
- Prickly Pear (1)
- Primaquin (1)
- Primärphosphankomplexe (1)
- Probenaufarbeitung (1)
- Prochlorococcus marinus (1)
- Prolin (1)
- Promotor <Genetik> (1)
- Promotorpolymorphismus (1)
- Propargyl (1)
- Propinolderivate (1)
- Propolis (1)
- Prostaglandine (1)
- Prostaglandinsynthase (1)
- Protease Inhibitoren (1)
- Protease Inhibitors (1)
- Protease inhibitors (1)
- Protease-Inhibitor (1)
- Protease-sensitive release (1)
- Proteaseinhibitoren (1)
- Proteasen (1)
- Protective Group Strategy (1)
- Protein Expression (1)
- Protein corona (1)
- Protein purification (1)
- Protein-Kristallisierung (1)
- Protein-Ligand Bindung (1)
- Protein-Protein-Interaktion (1)
- Protein-Protein-Interaktionen (1)
- Proteinaddukte (1)
- Proteinadsorption (1)
- Proteindesign (1)
- Proteinglutamin-Glutamyltransferase <Proteinglutamin-gamma-glutamyltransferase> (1)
- Proteinkinase C (1)
- Proteintyrosinphosphatase (1)
- Proteolysis-Targeting-Chimera (1)
- Proteom (1)
- Proteomanalyse (1)
- Proteomics (1)
- Protic Ionic Liquids (1)
- Protoonkogen (1)
- Protozoen (1)
- Provitamin A (1)
- Präamplifizierung (1)
- Prädissoziation (1)
- Prämix (1)
- Pseudodistomin C (1)
- Pseudomonas frederiksbergensis (1)
- Pulmonale Applikation (1)
- Pulmonary delivery (1)
- Pulsformung (1)
- Pulvermethode (1)
- Pump-CARS (1)
- Pump-Probe-Spektroskopie (1)
- Pump–probe spectroscopy (1)
- Purin (1)
- Purinorezeptor (1)
- Purity Control (1)
- Purity control (1)
- Pyracen (1)
- Pyramidalisierte Alkene (1)
- Pyramidalized Alkenes (1)
- Pyranonen (1)
- Pyridin (1)
- Pyridonderivate (1)
- Pyrimidinderivate (1)
- Pyroglutaminsäure (1)
- Pyrrinol (1)
- Pyrrolderivate (1)
- Pyrrolidin (1)
- Pyrrolidinderivate (1)
- Pyrrolizidinalkaloid-N-Oxid (1)
- Pyrrolizidinalkaloide (1)
- QD's symmetry (1)
- QIVIVE (1)
- QSPR (1)
- QSPR-Modeling (1)
- QTAIM (1)
- Quality ccontrol (1)
- Quamtum chemistry (1)
- Quantenchemische Rechnungen (1)
- Quantenelektrodynamik (1)
- Quantenkontrolle (1)
- Quantenmechanisches System (1)
- Quantentheoretische Chemie (1)
- Quantitative 1H NMR (1)
- Quantitative structure-property relationship modeling (QSPR) (1)
- Quantum Chemical CD Calculations (1)
- Quantum Dot (1)
- Quantum mechanics / molecular modeling (1)
- Quantum-Jump-Ansatz (1)
- Quasi-Newton-Verfahren (1)
- Quetiapin (1)
- RAB GTPases (1)
- RNA Helicase (1)
- RNA Helikase (1)
- RNA Labelling (1)
- RNA Methyltransferase (1)
- RNA degradation (1)
- RNA helicase (1)
- RNA metabolism (1)
- RNA modification (1)
- RNA recognition (1)
- RNA-Dependent RNA Polymerase (1)
- RNA-catalyzed RNA methylation (1)
- RNS-Ligase (1)
- ROP (1)
- ROS (1)
- RT -PCR (1)
- RTK (1)
- Radical-ion pair (1)
- Radicals (1)
- Radikal-Anion (1)
- Radikale (1)
- Radikalfänger (1)
- Radikalpaar (1)
- Radioindikator (1)
- Radiopharmaka (1)
- Radiosynthese (1)
- Raman Spectroscopy (1)
- Raman microspectroscopy (1)
- Rapid Prototyping <Fertigung> (1)
- Rastertunnelmikroskopie (1)
- Rat (1)
- Rauchgasgips (1)
- Raumklima (1)
- Reaction Mechanism (1)
- Reaction kinetics and dynamics (1)
- Reaktions-Diffusions-Systeme (1)
- Reaktionsbarrieren (1)
- Reaktionspfadsuche (1)
- Reaktive Intermediate (1)
- Reaktive Sauerstoffspezies (1)
- Reaktivitätsstudien (1)
- Rearrangement of carbocations (1)
- Receptor Dynamics (1)
- Recombinant DNA ; Growth hormone gene ; PCR; Silver carp ; Fish (1)
- Recombinant DNA ; polymerase chain reaction ; metallothionein gene ; rainbow trout ; fish (1)
- Recombinant protein expression (1)
- Recovery-Aroma (1)
- Recycling (1)
- Red Fruit Oil (1)
- Redox-Kaskade (1)
- Redoxkaskade (1)
- Redoxpotential (1)
- Redoxreaktion (1)
- Reduktion (1)
- Reduktionen (1)
- Regioselektivität (1)
- Registrierende Härteprüfung (1)
- Reinheit <Motiv> (1)
- Reinheitsprüfung (1)
- Rekombinantes Protein (1)
- Relaxation (1)
- Relaxationszeit (1)
- Release system (1)
- Remdesivir (1)
- Renin-Angiotensin-Aldosteron-System (1)
- Resonance Raman (1)
- Resonanz-Raman-Spektroskopie (1)
- Retinoblastoma Protein (1)
- Rezeptor-Antagonisten (1)
- Rezeptor-Kinasen (1)
- Rezeptorregulation (1)
- Rhenium (1)
- Rheniumkomplexe (1)
- Rheologische Eigenschaft (1)
- Rhizom (1)
- Ribozym (1)
- Ribozyme (1)
- Riechstoff (1)
- Riechstoffe (1)
- Rifampicin (1)
- Ring Expansion (1)
- Ring closing metathesis (1)
- Ringerweiterung (1)
- Ringerweiterungsreaktionen (1)
- Ringschlussmetathese (1)
- Risk Assessment (1)
- Rohkaffee (1)
- Rucola (1)
- Rumpfniveauanregung (1)
- Ruthemiumkomplexe (1)
- Ruthenium-Thioaldehyd-Komplexe (1)
- Räumliche Anordnung (1)
- Röntgenabsorptionsfeinstruktur (1)
- Röntgenpulverdiffraktometrie (1)
- Röstkaffee (1)
- S-ADAPT (1)
- SAR (1)
- SARS-CoV-2 (1)
- SARS-CoV-2 polymerase (1)
- SARS-CoV2 Replication Impairment (1)
- SHB (1)
- SHG (1)
- SIPGP (1)
- SMA (1)
- SMARD1 (1)
- SOFC (1)
- SPIO (1)
- STAT (1)
- STAT3 (1)
- STIRAP (1)
- SacB (1)
- Salmeterol (1)
- Sauerstoff (1)
- Sauerstoff-Oszillatoren (1)
- Sauerstoffdiffusionshärtung (1)
- Sauerstoffradikal (1)
- Scaffold (1)
- Scaffold <Biologie> (1)
- Scaffold <Tissue Engineering> (1)
- Scaffoldmaterialien (1)
- Scanner (1)
- Schaden (1)
- Schafgarbe <Gattung> (1)
- Schellack (1)
- Scherverhalten (1)
- Schichtsilicat (1)
- Schichtsilikat (1)
- Schiff-base (1)
- Schiffbase (1)
- Schiffsche Basen (1)
- Schizophrenie (1)
- Schizophrenieerkrankung (1)
- Schizosaccharomyces pombe (1)
- Schleim (1)
- Schleuderguss (1)
- Schlickergießen (1)
- Schlickerzusammensetzung (1)
- Schnelltest (1)
- Schutzgruppe (1)
- Schutzgruppenstrategie (1)
- Schwebeteilchen (1)
- Schwefel-Funktionalisierung (1)
- Schwefelatom (1)
- Schwefeldonor (1)
- Schwefeltransfer (1)
- Schwefelverbindungen (1)
- Schwein (1)
- Schweine-Caecum-Modell (1)
- Schwertkräpfling (1)
- Schwämme (1)
- Schädigung (1)
- Scleractinia (1)
- Scoring functions (1)
- Scoring-Funktionen (1)
- Scoringfunktionen (1)
- Sechste Nebengruppe (1)
- Secondary Bonding (1)
- Seide (1)
- Seiden-Fibroin (1)
- Sekundärstrukturen (1)
- Selbstassemblierung (1)
- Self-Assembly (1)
- Self-Sortierung (1)
- Self-Trapping (1)
- Self-assembly (1)
- Semiempirical Methods (1)
- Semiempirische Methode (1)
- Semiempirische Verfahren (1)
- Senecio spp. (1)
- Sensoren (1)
- Sensors (1)
- Serogruppe (1)
- Sesquiterpene lactones (1)
- Sesquiterpenlactonen (1)
- Shear stress indicator (1)
- Shelf-life (1)
- Si-C I Solid-state NMR (1)
- Si-H- Activation (1)
- Si-H-Aktivierung (1)
- Si-functional (1)
- Si=Si-Doppelbindung (1)
- SiC (1)
- Sialic acids (1)
- Sialinsäuren (1)
- Sila-Substitution (1)
- Sila-analogues (1)
- Sila-biperiden (1)
- Sila-difenidol (1)
- Sila-drug (1)
- Sila-hepronicate (1)
- Sila-hexocyclium (1)
- Sila-niceritrol (1)
- Sila-panamesine (1)
- Sila-pridinol (1)
- Silane (1)
- Silanes (1)
- Silanols (1)
- Silibinin (1)
- Silibinin ester (1)
- Silicat (1)
- Silicat Coordination Chemistry (1)
- Silicium Komplexe (1)
- Silicium(II)-Komplexe (1)
- Silicium(IV)-Komplexe (1)
- Siliciumhaltige Wirkstoffe (1)
- Siliciumnitrid (1)
- Silicon(II) Complexes (1)
- Silicon(IV) Complexes (1)
- Silicon-containing drugs (1)
- Silk-Fibroin (1)
- Silyl-Komplexen (1)
- Silylamine (1)
- Silylamines (1)
- Silylation (1)
- Silyllithium (1)
- Sintering (1)
- Sitagliptin (1)
- Site-specific RNA labelling (1)
- Site-specific modification (1)
- Small angle X-ray scattering (1)
- Sol-Gel-Prozess (1)
- Solanum tuberosum (1)
- Solarzelle (1)
- Solvatochromie (1)
- Solvolyse (1)
- Solvolysen (1)
- Solvolyses (1)
- Somatostatin (1)
- Somatostatinrezeptor Subtyp 4 (1)
- Somatotropin (1)
- Sonde (1)
- Sonogashira reaction (1)
- Sorafenib (1)
- Sorbitolfermentierer (1)
- Spannungskontrollierter Ionenkanal (1)
- Sparus aurata (1)
- SpecDis (1)
- Spectrin (1)
- Spectrofluorimetry (1)
- Speichel (1)
- Speicher <Informatik> (1)
- Speicherprofil (1)
- Spektrin (1)
- Spermin (1)
- Sphingolipid (1)
- Sphingolipide (1)
- Sphingosin (1)
- Spin flip (1)
- Spinale Muskelatrophie (1)
- Spindichte (1)
- Spir (1)
- Spirooxazine (1)
- Spiropiperidine (1)
- Spirosilicate (1)
- Spirosilicates (1)
- Spirotetracyclo[4.1.0.0<sup>2 (1)
- Sponges (1)
- Spray drying (1)
- Springs and Parachutes (1)
- Sprungmodell (1)
- Sprühtrocknung (1)
- Spumaviren (1)
- Spurenelement (1)
- Spurenelemente (1)
- Squalen (1)
- Src family (1)
- Stacking (1)
- Stannylenes (1)
- Staphylococci (1)
- Staphylococcus (1)
- Stat6 (1)
- State Estimation (1)
- Statine (1)
- Stattic (1)
- Stenotrophomonas maltophilia (1)
- Stent (1)
- Stereochemical Memory Effect (1)
- Stereochemischer Erinnerungseffekt (1)
- Stereochemistry . Linkage Isomerism (1)
- Stereoselective Synthesis (1)
- Stereoselektiv (1)
- Sterische Hinderung (1)
- Stiban (1)
- Stickstoffmonoxid-Synthase (1)
- Stickstoffverbindungen (1)
- Stochastische Resonanz (1)
- Stochastischer Prozess (1)
- Stoffbilanz (1)
- Strahlungslose Desaktivierung (1)
- Strained Rings (1)
- Strawberry (1)
- Strength (1)
- Streptomycin (1)
- Structural elucidation (1)
- Structure (1)
- Structure Bis(diethyldithiocarbamato)phenylphosphane (1)
- Structure Elucidation (1)
- Strukturaufklärungen (1)
- Strukturierung (1)
- Strukturoptimierung (1)
- Strukturtreue (1)
- Strychnin (1)
- Strychnosalkaloide (1)
- Strömung (1)
- Strömungsverhalten (1)
- Stufenwachstums-Polymerisation (1)
- Stylissa carteri (1)
- Stöber silica (1)
- Stöber-Silica (1)
- Störungstheorie (1)
- Substituent effects (1)
- Substituenten Effekte (1)
- Substratbindung (1)
- Subtraktionsmethoden (1)
- Subtypselektivität (1)
- Suc1 (1)
- Sulfat (1)
- Sulfate (1)
- Sulfatkonjugate (1)
- Sulfit (1)
- Sulfite (1)
- Sulfonamide (1)
- Sulfonyldiazomethan (1)
- Sulfoxidation (1)
- Sulfoxide (1)
- Sulfur (1)
- Sulfur transfer (1)
- Sulfurierung (1)
- Sulphur (1)
- Superior cervical ganglia (calf) (1)
- Superparamagnetismus (1)
- Supersaturation (1)
- Support Vector Regression (1)
- Supramolecular electronics (1)
- Supraparticle (1)
- Surface enhance Raman scattering (SERS) (1)
- Surface modifiaction (1)
- Surface modification (1)
- Surface plasmons (1)
- Survival Motor Neuron (1)
- Symmetrie der Quantenpunkte (1)
- Synaptische Vesikel (1)
- Synaptophysin (1)
- Synchrotron (1)
- Synchrotron Radiation (1)
- Synthetische Polypeptide (1)
- Synthetischer Farbstoff (1)
- System-Bad-Ansatz (1)
- Sythese (1)
- Säure (1)
- Süßstoffe (1)
- Süßwasserpolypen (1)
- T = 100 K (1)
- T = 174 K (1)
- T = 199 K (1)
- T cell (1)
- T cells (1)
- T lymphocytes (1)
- T-Lymphoblastomzellen (1)
- T-Lymphozyt (1)
- T-Lymphozyten (1)
- T-Zell-Leukämie (1)
- T-cells (1)
- TCDD (1)
- TEM (1)
- TERRA RNA (1)
- TGA (1)
- TGF-β3 (1)
- TPES (1)
- TRESK (1)
- TRI (1)
- Tabletten (1)
- Tabu-Search (1)
- Tabusuche (1)
- Tacrin (1)
- Tandem Mass Spectrometry (1)
- Tandem-Wittig-1 (1)
- Tantalverbindungen (1)
- Tastwahrnehmung (1)
- Tectosilicate (1)
- Teilchen (1)
- Temperaturabhängigkeit (1)
- Temperaturbeständigkeit (1)
- Temperaturleitfähigkeit (1)
- Temperatursensor (1)
- Terpene (1)
- Terphenyl Derivate (1)
- Terphenylderivate (1)
- Terpyridin (1)
- Terpyridinderivate <2 (1)
- Terpyridinderivate <2,2':6',2''-> (1)
- Terrylenbisimid (1)
- Terrylenderivate (1)
- Terrylene bisimide (1)
- Tetrahydro-15aH-azocino[1 (1)
- Tetrahydro-b-carboline (1)
- Tetrahydro[1 (1)
- Tetrahydrochinazoline (1)
- Tetrahydrofuran (1)
- Tetrahydrofurane (1)
- Tetrakis(arylmethylene)ethane diradical (1)
- Tetrakoordinierte Verbindungen (1)
- Tetralon (1)
- Tetralone (1)
- Thalassodendron ciliatum (1)
- Thalidomid (1)
- Theoretische Charakterisierung (1)
- Theorie (1)
- Therapeutic Drug Monitoring (1)
- Therapeutikum (1)
- Therapeutisches System (1)
- Therapiekontrolle (1)
- Thermal-Shock (1)
- Thermoanalyse (1)
- Thermolyse (1)
- Thermoschock (1)
- Thermoschockverhalten (1)
- Therpeutisches Drug Monitoring (1)
- Thiiran (1)
- Thiireniumion (1)
- Thin-layer chromatography (1)
- Thioaldehyd (1)
- Thioaldehyd- (1)
- Thioaldehyd-Komplexe (1)
- Thioaldehydkomplexe (1)
- Thioether-Poly(glycidol) (1)
- Thioether-Poly(glycidol)-Beschichtung (1)
- Thiolase (1)
- Thiolat-Liganden (1)
- Thiolate (1)
- Thiopyran (1)
- Thiopyrane (1)
- Thiozimtaldehyd (1)
- Thrombozyt (1)
- Ti(Ag) Beschichtungen (1)
- Ti(Ag) coatings (1)
- Tierversuche (1)
- Time-Dependent Density Functional Theory (1)
- Time-dependent Density Functional Theory (1)
- Timolol (1)
- Tin (1)
- Tiplet emiters (1)
- Tiplett Emitter (1)
- Titaniumdioxide (1)
- Toll-like-Rezeptoren (1)
- Tongue (1)
- Toxicology (1)
- Toxikokinetik (1)
- Toxin (1)
- Transfer-RNS (1)
- Transient Absorption (1)
- Transient Grating (1)
- Transiente Absorptionsspektroskopie (1)
- Transiente Gitter (1)
- Transition Metals (1)
- Transition metals (1)
- Transkription (1)
- Translation (1)
- Transmission electron microscopy (1)
- Transparent-leitendes Oxid (1)
- Triad (1)
- Triazin (1)
- Trichlorethylen (1)
- Trichter (1)
- Tricyclo[3.3.1.0 2 (1)
- Tricyclo[4.1.0.0<sup>2.7</sup>]heptanes (1)
- Tricycloheptanderivate (1)
- Trifluorpropionsäure (1)
- Trihexyphenidyl (1)
- Trimebutin (1)
- Triphenyltelluroniumsulfide (1)
- Triphyophyllum peltaturn (1)
- Triplett (1)
- Tripyrrine (1)
- Tripyrrins (1)
- Trockenblutanalytik (1)
- Tropenkrankheit (1)
- Tropische Pflanzen (1)
- Truxenon (1)
- Trypanosoma brucei brucei (1)
- Trypanosoma cruzi (1)
- Tryptophan (1)
- Tuberkulose (1)
- Tumorsuppressor-Gen (1)
- Tumorzelle (1)
- Tungsten complexes (1)
- Tungsten-carbonyl-Complexes (1)
- Tweezer-Rezeptoren (1)
- Two-Hybrid-System (1)
- Typanosoma (1)
- Typselektivität (1)
- Tyrosinase (1)
- UHPLC (1)
- UHPLC-ESI-MS/MS (1)
- UV Schutzen (1)
- UV Schuzen (1)
- UV-Spektroskopie (1)
- UV-VIS-Spektroskopi (1)
- UV-VIS-Spektroskopie (1)
- UV/Vis spectroscopy (1)
- UV/Vis-Absorption (1)
- Ubiquitin (1)
- Uebergangsmetallkomplexe (1)
- Ugi-azide reaction (1)
- Ultrafast spectroscopy (1)
- Ultraschall (1)
- Ultraschallprüfung (1)
- Ultrastruktur (1)
- Ultraviolett-Bestrahlung (1)
- Ultraviolettlaser (1)
- Ultraviolettspektroskopie (1)
- Umbrella Sampling (1)
- Umgebungseffekte (1)
- Umgebungseinfluss (1)
- Umlagerung (1)
- Umlagerungen (1)
- Umpolung (1)
- Umwandlungsverstärkung (1)
- Ungesättigte Verbindungen (1)
- Universität Würzburg. Lehrstuhl für Pharmazeutische Technologie und Biopharmazie (1)
- Unterernährung (1)
- Unterrichtsmethode (1)
- Uranium (1)
- Urazoles (1)
- UsnRNP (1)
- V. wallichii (1)
- VAMS (1)
- VASP (1)
- VIDE (1)
- VIDED (1)
- VSD (1)
- Vaccinia-Virus (1)
- Vaccinium myrtillus <Homöopathie> (1)
- Vakuum Jet-Flash Pyrolyse (1)
- Vakzinia (1)
- Valenzgemischte Verbindungen (1)
- Van-der-Waals-Cluster (1)
- Van-der-Waals-Kraft (1)
- Vanadium(V)- und Cobalt(II)-katalysierte Oxidation (1)
- Vancomycin (1)
- Vas deferens (1)
- Vas deferens (rabbit) (1)
- Vascularization (1)
- Vektor (1)
- Velocity Map Imaging (1)
- Venlafaxin (1)
- Ventrikelseptumdefekt (1)
- Veracruz <Stadt> (1)
- Verbundwerkstoff (1)
- Verderb (1)
- Verfügbarkeit (1)
- Verfütterungsexperiment (1)
- Vergleich (1)
- Vermahlung (1)
- Verunreinigugsprofil (1)
- Verunreinigungen (1)
- Verzögerte Fluoreszenz (1)
- Vesikel (1)
- Vidcomicroscopy (1)
- Vierte Nebengruppe (1)
- Vierwellenmischen (1)
- Vinylaminoborane (1)
- Vinyliden (1)
- Vinyliden- (1)
- Vinylidene (1)
- Virtual Screening (1)
- Virusrezeptor (1)
- Volumetric absorptive microsampling (1)
- W84 (1)
- Wachstum (1)
- Wachstumshemmung (1)
- Wandmalerei (1)
- Wassereinflüsse (1)
- Wasseroxidationsreaktion (1)
- Wasserreinigung (1)
- Wasserspaltung (1)
- Wasserstoffatom (1)
- Wasserstoffbrücken (1)
- Wasserstoffionenkonzentration (1)
- Water resources (1)
- Weakly chromophore impurities (1)
- Wechselwirkung (1)
- Weitz-Scheffer Reaktion (1)
- Weitz-Scheffer reaction (1)
- Weißer Phosphor (1)
- Wellenpaket (1)
- Wellenpaketdynamik (1)
- Wertstoffrückgewinnung (1)
- Wirkstoffspeichersystem (1)
- Wirt-Gast-Wechselwirkung (1)
- Wirts-Gast-Einschlusskomplex (1)
- Wittig-reaction (1)
- Wolframcarbonyl-Komplexe (1)
- Wolframcarbonyle (1)
- Wässrige Lösung (1)
- Würzburg / Institut für Anorganische Chemie (1)
- Würzburg / Sonderforschungsbereich Erkennung (1)
- X-Ray (1)
- X-Ray Crystal Structure (1)
- X-Ray Powder Diffraction (1)
- X-ray (1)
- X-ray diffraction (1)
- X-ray diffractometry (1)
- XRD (1)
- Xanomeline (1)
- Xanthin (1)
- Xanthinoxidase (1)
- Xenobiotikum (1)
- Xenoöstrogene (1)
- YAG (1)
- YTH reader proteins (1)
- ZEKE (1)
- Zebrafisch (1)
- Zeitaufgelöste Spektroskopie (1)
- Zeitauflösung (1)
- Zelldifferenzierung (1)
- Zellkultur (1)
- Zelloberfläche (1)
- Zellträgermaterial (1)
- Zellzyklus-Kontrolle (1)
- Zentralnervensystem (1)
- Zeolites (1)
- Zeolithe (1)
- Zerkleinerungsverhalten (1)
- Zetapotential (1)
- Ziegler-Natta-Katalysator (1)
- Ziest (1)
- Zimtaldehyd (1)
- Zinc Chlorin (1)
- Zink-Luft-Akkumulator (1)
- Zinkchlorin (1)
- Zinkchlorine (1)
- Zinnverbindungen (1)
- Zirkulardichroismus Spektroskopie (1)
- Zuckerphosphat (1)
- Zugpannung (1)
- Zugspannungstester (1)
- Zunge (1)
- Zuordnung (1)
- Zusatzstoff (1)
- Zustandserkennung (1)
- Zwei-Photonen-Polymerisation (1)
- Zweiatomiges Molekül (1)
- Zweidimensionale NMR-Spektroskopie (1)
- Zweikernige Komplexe (1)
- Zwischenmolekulare Kraft (1)
- Zwitterionic (1)
- Zwitterionic [lambda]5-Spirosilicates (1)
- Zygosaccharomyces (1)
- Zygosaccharomyces rouxii (1)
- [1 (1)
- [1.1.1]Propellan (1)
- [1.1.1]propellane (1)
- [2 + 2]- and [4 + 2]- (1)
- [3H]-Hexahydro-siladifenidol (1)
- [n]helicenes (1)
- \(\pi\) interactions (1)
- \(\pi\)-Komplexe (1)
- \(^{1}\)HNMR (1)
- ab initio calculations (1)
- abiotische (1)
- absolute configuration (1)
- absorption (1)
- acaricides (1)
- acceptor (1)
- acenes (1)
- acetophenone (1)
- acetyl- (1)
- acetylcholinesterase inhibitors (1)
- acid-sensitive (1)
- acids (1)
- acridizinium salts (1)
- active agents (1)
- active pharmaceutical ingredient (1)
- active pharmaceutical ingredients (1)
- acylated quercetin-tri-glucosides (1)
- adaptive Materialien (1)
- additive manufacturing (1)
- adenine (1)
- adenosine receptors (1)
- adhesion (1)
- adolescents (1)
- adsorption (1)
- advanced drug delivery system (1)
- afatinib (1)
- affinity (1)
- aggregation (1)
- agomelatine (1)
- air humidity (1)
- aldehydes (1)
- alignment-free (1)
- alignment-frei (1)
- alkene (1)
- alkene-alkyne [2+2] photocycloaddition (1)
- alkoxysilanes (1)
- alkylidengruppe (1)
- alkylpyrazines (1)
- alkyne (1)
- all-fish genes (1)
- alleles (1)
- allergic rhinitis (1)
- allometric scaling (1)
- allostere Modulation (1)
- allosterischer Effektor (1)
- alloys (1)
- allyl (1)
- allylic alcohols (1)
- alpha (1)
- alpha Glucosidase (1)
- alpha-Effekt (1)
- alpha-Hydroxy carbon acids (1)
- alpha-Sekretase (1)
- alpha-helical structure (1)
- alpha2-KO Maus (1)
- alpha2-KO mouse (1)
- alpha2-Rezeptor (1)
- alpha2-adrenerge Rezeptoren (1)
- alpha2-adrenergic receptors (1)
- alpha2-receptor (1)
- aluminum (1)
- alzheimer's disease (1)
- amber light (1)
- amido (1)
- amino acid (1)
- amino acid sequence (1)
- amino groups (1)
- aminotroponiminates (1)
- ammonium compounds (1)
- amorph (1)
- amorphous (1)
- amorphous solid dispersion (1)
- amphiphilic dyes (1)
- amphiphilic poly(2-oxazoline)s (1)
- amphiphilic systems (1)
- amyloid beta (1)
- anandamide (1)
- ancient coloured glass (1)
- ancistrocladinium A (1)
- androgen-induced masculinization (1)
- angeregte Zustände (1)
- angeregte Zustände in Aggregaten (1)
- animal studies (1)
- anionic Complexes (1)
- anionic carbene (1)
- anionic tungsten complexes (1)
- anionische Komplexe (1)
- anionische Wolfram-Komplexe (1)
- anorganisch-organische Hybridpolymere (1)
- anorganisch-organisches Hybridpolymer (1)
- ansa (1)
- ansa complexes (1)
- ansa-Metallocenes (1)
- ansa-complexes (1)
- ansa-metallocenes (1)
- anthocyanin (1)
- anthocyans (1)
- anthracene (1)
- anti van't Hoff/Le Bel-compounds (1)
- anti-inflammatory cytokines (1)
- anti-proliferative effects (1)
- anti-van't Hoff/Le Bel Verbinfungen (1)
- antiaromaten (1)
- antiaromates (1)
- antiaromaticity (1)
- antibacterial (1)
- antibakteriell (1)
- antibiotic (1)
- antifungal (1)
- antiinflammatory (1)
- antimicrobial activities (1)
- antimuscarinics (1)
- antioxidant (1)
- antipsychotics (1)
- antiviral agents (1)
- antiviral drugs (1)
- aplysiapyranoids (1)
- aqueous (1)
- aqueous humor (1)
- aqueous processing (1)
- arching (1)
- arginine methylation (1)
- aroma profile (1)
- aromates (1)
- arsine (1)
- artificial light harvesting systems (1)
- artificial sweeteners (1)
- arylmetalate (1)
- aspartic proteases (1)
- asymmetric synthesis (1)
- asymmetrische Synthese (1)
- at-metal-chirale Rhenium-Komplexe (1)
- at-metal-chirale Rheniumkomplexe (1)
- atomic layer deposition (1)
- atomic mutagenesis (1)
- atropine (1)
- atropisomer (1)
- automated solid-phase Edman degradation (1)
- automation (1)
- autophagosome formation (1)
- availability (1)
- azaborole (1)
- azadiboretidines (1)
- aziridin (1)
- aziridine (1)
- azobenzenes (1)
- bacterial resistance (1)
- barrier (1)
- basin hopping (1)
- beclomethasone (1)
- benchmark (1)
- benzvalene (1)
- benzyl radical (1)
- beryllium (1)
- beschichtetes Elektrodenmaterial (1)
- beta substitution (1)
- beta-Carotene (1)
- beta-Carotin (1)
- beta-Oxidation (1)
- beta-Substitution (1)
- beta-lactam antibiotics (1)
- beta-oxidation (1)
- betony (1)
- bexarotene (1)
- bicyclic (1)
- bile (1)
- bimodal contrast agent (1)
- bimodale Kontrastmittel (1)
- binding (1)
- binding constant (1)
- binding mechanism (1)
- binding sites (1)
- binuclear complexes (1)
- bio-printability (1)
- bioactivities (1)
- bioassay (1)
- bioassay-guided fractionation (1)
- bioavailability (1)
- bioceramics (1)
- bioconjugate (1)
- biodegradable polymer (1)
- biodegradierbar (1)
- biofilm (1)
- biohydroxylation (1)
- bioinks (1)
- bioinorganic chemistry (1)
- biolabelling (1)
- biolayerinterferometry (1)
- biological activities (1)
- biological photoreceptors (1)
- biologically active molecules (1)
- biologics (1)
- biologisch aktiven Moleküle (1)
- biologische Aktivitäten (1)
- biologische Körperflüssigkeiten (1)
- biologische Photorezeptoren (1)
- bioluminescence resonance energy transfer (1)
- biomass (1)
- biominarlization proteins (1)
- biomineralization (1)
- bioorganic chemistry (1)
- bioorganometallic chemistry (1)
- bioorthogonal (1)
- bioorthogonal SAM analogue ProSeDMA (1)
- bioorthogonal metabolic glycoengineering; click chemistry; sialic acid (1)
- biophysical investigation (1)
- bioprinting (1)
- bioresponsive (1)
- biosynthetic investigations (1)
- bisphenol A (1)
- bisphosphonates (1)
- bispidine (1)
- bitopic hybrid ligands (1)
- bitopic ligands (1)
- bivalent hybrid compounds (1)
- blend (1)
- block copolymers (1)
- blood plasma (1)
- blood-contact (1)
- blueberry (1)
- body composition (1)
- body size (1)
- bola-amphiphile (1)
- bond Activation (1)
- bond analysis (1)
- bond formation (1)
- bond polarisation (1)
- bond theory (1)
- bonding analysis (1)
- bonding mechanisms (1)
- bondlength alternation (1)
- bone (1)
- bone morphogenetic protein (1)
- bone penetration (1)
- borafluorenes (1)
- boraselenone (1)
- borate (1)
- borates (1)
- borido (1)
- borido complexes (1)
- borirane (1)
- borirenes (1)
- boroles (1)
- boron reagents (1)
- boron tetraiodide (1)
- boron-doped diamond (1)
- boronate ester (1)
- boronate esters (1)
- boronates (1)
- boryl (1)
- boryl anions (1)
- borylene complex (1)
- borylene complexes (1)
- borylene transfer (1)
- borylene-transition metal complexes (1)
- borylenes (1)
- bourgeonal (1)
- breakage behaviour (1)
- bridge (1)
- bridging (1)
- brown seaweeds (1)
- bulk powder (1)
- bulk solid (1)
- bulky ligands (1)
- bunte Glasperlen (1)
- cAAC (1)
- cAArC (1)
- cAMP (1)
- cDNA-Array (1)
- cDNA-array (1)
- caffeic acid bornyl ester (1)
- calcium fluoride nanoparticles (1)
- calciumhydroxide (1)
- calix[4]arene (1)
- calmodulin (1)
- calorimetry (1)
- carbamate (1)
- carbene complexes (1)
- carbene ligands (1)
- carbene-stabilized nickel complexes (1)
- carbocations (1)
- carbohydrate chemistry (1)
- carbon nanomaterials (1)
- carbon nanotube (1)
- carbon nanotubes (1)
- carbonic acid (1)
- carbonyl (1)
- carbonyl complexes (1)
- carboxylate receptor (1)
- carmine (1)
- cartilage (1)
- cartilage tissue engineering (1)
- catechines (1)
- cathepsin (1)
- cathode material (1)
- cefotiam (1)
- cell (1)
- cell adhesion (1)
- cell cycle (1)
- cell cycle control (1)
- cell differentiation (1)
- cellline transfection (1)
- cellmigration (1)
- cells (1)
- centrifugally casting (1)
- ceramic polymer composite (1)
- ceramide (1)
- cerebroside (1)
- cerulenin (1)
- chain reaction (1)
- chalcogens (1)
- chalcone (1)
- charge carrier generation (1)
- charge separation (1)
- charge transport; hydrogen bonding; oligothiophene; organogel; self-assembly (1)
- charge-separated state (1)
- charged aerosol detector (1)
- charging (1)
- chemical biology (1)
- chemometrics (1)
- chemoselective (1)
- chemosensitivity (1)
- chemotaxis (1)
- chila catalysis (1)
- children (1)
- chimeric RTKs (1)
- chiral control (1)
- chiral ligands (1)
- chiral recognition (1)
- chiral resolution (1)
- chirale Erkennung (1)
- chirale Kathalyse (1)
- chirale Kontrolle (1)
- chirale Liganden (1)
- chirale Trennung (1)
- chirality and odour (1)
- chirality transfer (1)
- chloral (trichloroacetaldehyd) (1)
- chlorin (1)
- chlorophyll (1)
- cholesterol and oxy-cholesterol (1)
- cholinesterase (1)
- cholinesterase inhibitors (1)
- chromaffin granulas (1)
- chromaffine Granulas (1)
- chromophore (1)
- chronic IBD model (1)
- circular-dichroism (1)
- circularly polarized luminescence (1)
- classical and nonclassical (1)
- click CuAAC synthesis (1)
- clinical pharmacy (1)
- clonidine (1)
- clopidogrel (1)
- cluster analysis (1)
- co-delivery (1)
- co-gels (1)
- coated electrode material (1)
- coating (1)
- coatings (1)
- cobalt complexes (1)
- cocrystal (1)
- cocrystallization (1)
- cofactorbinding (1)
- coherent anti-Stokes Raman scattering (1)
- coherent anti-Stokes Raman scattering (CARS) (1)
- cohesion (1)
- cohesive bulk powder (1)
- collagen (1)
- colloidal nanostructures (1)
- colloids (1)
- colon cancer (1)
- colon-targeting (1)
- commercial preparations (1)
- complexation (1)
- complexes (1)
- composite supraparticles (1)
- composites (1)
- concentrate (1)
- condensation (1)
- configurational stability (1)
- confocal Raman microscopy (1)
- confocal Raman-spectroscopy (1)
- confocal micro-Raman spectroscopy (1)
- conformation (1)
- conformational anylysis (1)
- conformational search (1)
- conjugated molecule (1)
- conjugated systems (1)
- contaminants (1)
- continuous ultrafiltration (1)
- control theory (1)
- coordination compounds (1)
- coordination oligomer (1)
- coordination polymers (1)
- copolymerization (1)
- copper and iron doped glass systems (1)
- core level excitation (1)
- core-shell particles (1)
- correlation (1)
- corrosion sensitive (1)
- coumarin (1)
- counterfeit drugs (1)
- coupled (1)
- coupled electron-nuclear motion (1)
- coupled nuclear-electron MCTDH (1)
- coupling reactions (1)
- covalent inhibition (1)
- covalent reversible inhibition (1)
- creatinine (1)
- critical points (1)
- cryostructuring (1)
- crystal structure of (1)
- crystalline (1)
- crystallographic analyses (1)
- curcumin (1)
- cyanoborate (1)
- cyanoborates (1)
- cyclic (alkyl)(amino) carbenes (1)
- cyclic / 1-0xa-2 (1)
- cyclic alkyl(amino)carbenes (1)
- cyclic trimer (1)
- cyclic voltammetry (1)
- cyclische Trimere (1)
- cycloaddition (1)
- cycloadditions (1)
- cyclodehydrogenation (1)
- cyclodextrins (1)
- cyclopenta[c]pyran-3(5H)-one (1)
- cyclopenta[c]pyran-3(7H)-one (1)
- cyclopenta[c]pyrans (1)
- cyclopenten-4-yl cation (1)
- cyclophane (1)
- cymantrene (1)
- cystein (1)
- cystein protease inhibitor QSAR (1)
- cysteine proteases (1)
- cystic fibrosis (1)
- cystic fibrosis patients (1)
- cyto-compatibility (1)
- cytochrome P450 enzyme (1)
- cytochrome P450 enzymes, carboxylesterases, glutathione S-transferases (1)
- cytochrome p450 (1)
- cytochrome-P-450 (1)
- cytoskeleton dynamics (1)
- dG (1)
- d]cycloheptene (1)
- dachsous (1)
- daidzein (1)
- damage (1)
- damascone (1)
- data-to-parameter ratio = 14.0. (1)
- data-to-parameter ratio = 20.8 (1)
- data-to-parameter ratio = 23.6. (1)
- deagglmeration (1)
- decafluoroazobezene (1)
- decision support (1)
- degradation (1)
- degradation of fatty acids (1)
- dehydration (1)
- delayed fluorescence (1)
- demethylase enzymes FTO and ALKBH5 (1)
- dendrimer (1)
- density functional theory (1)
- density gradient ultracentrifugation (1)
- density weighted imaging (1)
- density weighting (1)
- dental adhesiv (1)
- deoxyhypusinhydroxylase (1)
- deoxyribozymes (1)
- deposition (1)
- deracemization (1)
- derivates (1)
- derivatisation (1)
- device-related infections (1)
- diabetes (1)
- dialysis (1)
- diastereomer (1)
- diazadiborinines (1)
- dibenzobarrelenes (1)
- diboran(4)yl platinum complex (1)
- diborane (1)
- diborane(4) (1)
- diboranes (1)
- diboranes(4) (1)
- diboration (1)
- diboren (1)
- dicarbonyl (1)
- dicoordinate borylene (1)
- dicyclidol (1)
- difenidol (1)
- differential Shannon entropy (1)
- differential scanning calorimetry (1)
- diffusion constant (1)
- diketopiperazines (1)
- diketopyrrolopyrrole (1)
- dimer (1)
- dimer method (1)
- dimere Liganden (1)
- dimeric ligands (1)
- dimeric strychnine ligands (1)
- dioxetane (1)
- dipolar aggregation (1)
- dipolare Addition (1)
- dipyridamole (1)
- directional solidification (1)
- discharge (1)
- discotic liquid crystals (1)
- dissipative Umgebung (1)
- dissipative environments (1)
- dissoziative Photoionisation (1)
- docking studies (1)
- donor-acceptor dyad (1)
- donor-acceptor interactions (1)
- donor-photosensibilisator-acceptor triad (1)
- donor–acceptor (1)
- doppler broadening (1)
- dose individualization (1)
- dose linearity (1)
- dosimeter (1)
- double bonds (1)
- dried bilberries (1)
- drug delivery system (1)
- drug formulation (1)
- drug impurities (1)
- drug repurposing (1)
- drug-monitoring (1)
- dry spinning (1)
- dual setting system (1)
- dualsteric (1)
- dualsteric ligand (1)
- dye adsorption (1)
- dye stains-all (1)
- dynamic (1)
- effector Treg (eTreg) (1)
- efflux pumps (1)
- elastic-plastic properties (1)
- elastischer Eindringmodul (1)
- electrochemical conversion (1)
- electrochemical fluorination (1)
- electrolytes (1)
- electron density (1)
- electron localization (1)
- electron storage (1)
- electronic and spintronic devices (1)
- electronic devices (1)
- electronic differentiation (1)
- electronic excitation (1)
- electronic structure (1)
- electron–nuclear dynamics (1)
- electrophilic (het)arene (1)
- electrophoresis (1)
- electrorheologial fluids (1)
- electrorheological fluid (1)
- electrorotation measurement (1)
- electrospun fibers (1)
- elektronische Differenzierung (1)
- elektrorheologische Flüssigkeit (1)
- elektrorheologische Flüssigkeiten (1)
- elongation (1)
- emulsion (1)
- emulsions oil-in-water (1)
- enantiodifferentiation (1)
- enantiomer (1)
- enantiomerenrein (1)
- enantiomerization (1)
- enantiomers of / Muscarinic receptors (1)
- enantiopure (1)
- enantioselective (1)
- enantioselectivity (1)
- enantioselektiv (1)
- enediyne (1)
- energy landscapes (1)
- enol ether (1)
- enoyl-ACP reductase inhibitors (1)
- enoyl-ACP-reductase (1)
- entropy (1)
- environmental effects (1)
- enyne (1)
- enzym kinetic (1)
- enzymatic (1)
- enzyme kinetics (1)
- enzyme screening (1)
- enzymes (1)
- episulfide (1)
- epoxides (1)
- ergosterol derivative (1)
- erythromycin (1)
- esculentus (1)
- essential oils (1)
- esterase (1)
- esters and alcohols (1)
- estrogens (1)
- ethamoxytriphetol (1)
- ethanolaminphosphate (1)
- ethyl (1)
- ethylene complexes (1)
- evaporation based detectors (1)
- evaporationsbasierte Detektoren (1)
- ex vivo (1)
- ex vivo Modell (1)
- ex-chiral-pool synthesis (1)
- exact conical intersection dynamics (1)
- exact wave function (1)
- exakte Wellenfunktion (1)
- excipient (1)
- excitability (1)
- excited state (1)
- excited states in aggregates (1)
- exciton coupling (1)
- exciton exciton annihilation (1)
- exciton transport (1)
- excitotoxicity (1)
- experimental and theoretical determination of electron density (1)
- expert systems (1)
- extra cellular matrix (1)
- extracellular matrix (1)
- eye (1)
- family (1)
- fat (1)
- fatty acid biosynthesis (1)
- fatty acid methyl ester (1)
- fatty acid synthesis II (1)
- fatty acids (1)
- femtosecond time-resolved spectroscopy (1)
- fenbutatinoxide (1)
- fermentation (1)
- fermentation alcohols (1)
- ferrocene (1)
- ferrocenophanes (1)
- ferroelectricity (1)
- fiber (1)
- fiber probe (1)
- fibre-reinforcement (1)
- fjx (1)
- fjx1 (1)
- flame retardants (1)
- flame test (1)
- flavonoid (1)
- flavour substances (1)
- flexibility (1)
- flow (1)
- flow properies (1)
- flow properties (1)
- flow-conditioners (1)
- fluidised bed granulation (1)
- fluorenscence (1)
- fluorescence assay (1)
- fluorescence polarization (1)
- fluorescence resonance energy transfer (1)
- fluorescence switches (1)
- fluorescent ligands (1)
- fluorescent probe (1)
- fluorimetric assay (1)
- fluorination (1)
- fluorine marker (1)
- fluorine-18 (1)
- fluoroarenes (1)
- fluoroborates (1)
- fluoroquinolones (1)
- foamy virus (1)
- folded macrocyles (1)
- folding landscapes (1)
- food additives (1)
- food safety (1)
- force field (1)
- formaldehyde (1)
- forms (1)
- formulation development (1)
- four wave mixing spectroscopy (1)
- four-jointed (1)
- fractal dimension (1)
- fractionation (1)
- fragment screening (1)
- free energy calculations (1)
- free fatty acids (1)
- free jet (1)
- free radicals (1)
- free-base porphyrins (1)
- frequency conversion (1)
- fruit juice (1)
- fumonisin B1 (1)
- functional coatings (1)
- functional dyes (1)
- functional initiators (1)
- funktionale Präpolymere (1)
- funktionelle Schichten (1)
- furanone (1)
- fused boracycles (1)
- galaxolide (1)
- galbanone (1)
- galectin-1 (1)
- gamma delta (1)
- geformte Laserfelder (1)
- gel point (1)
- gemischtvalente Verbindung (1)
- generation and rearrangement (1)
- genetic codon expansion (1)
- genetic interactions (1)
- genetics (1)
- genotoxicity (1)
- genotyping (1)
- gentamicin (1)
- gentamicin sulfate (1)
- getrocknete Heidelbeeren (1)
- glass (1)
- glass ceramic (1)
- glass transition temperature (1)
- glassceramic (1)
- glidant (1)
- global minimum (1)
- glucocorticoids (1)
- glucose lowering (1)
- glucosinolates (1)
- glutamate receptors (1)
- glutamates (1)
- glutathione (1)
- glycopeptide antibiotics (1)
- gold (1)
- gprotein (1)
- gradient HPLC–UV (1)
- green coffee beans (1)
- green notes (1)
- group 8 metals (1)
- growth hormone gene (1)
- guanine (1)
- gynogeaesls (1)
- h-dimerization (1)
- halbleitende Polymere (1)
- halichondria panicea (1)
- halides (1)
- halogens (1)
- haptic (1)
- hardness (1)
- healthy volunteers (1)
- heart (1)
- heart rate (1)
- heat sink (1)
- hemilabil (1)
- hemilabile (1)
- heparin (1)
- hepatitis (1)
- hepatotoxicity (1)
- heterochromatin protein 1 (1)
- heterocyclic tetrylenes (1)
- heteroelement (1)
- hetrocyclic tetrylene complexes (1)
- hexaarylbenzenes (1)
- hexacoordinate (1)
- hexacoordination (1)
- hexahydro-difenidol enantiomers (1)
- hexakisadducts (1)
- hexakoordinierte (1)
- hexasila-fenbutatinoxide (1)
- hey (1)
- high drug loading (1)
- high harmonic generation (1)
- high throughput screening (1)
- high-resolution tandem mass spectrometry (1)
- high-temperature chemistry (1)
- higher-coordinate germanium (1)
- higher-coordinate silicon (1)
- higher-coordination (1)
- highly substituted (1)
- histamine (1)
- hollow spheres (1)
- homodimerization (1)
- homology modeling (1)
- honey (1)
- hopping model (1)
- host-guest systems (1)
- host-guest-complexation (1)
- hplc (1)
- human breast (1)
- human metabolism (1)
- human nutrition (1)
- human plasma (1)
- human receptor kinetics (1)
- hybrid (1)
- hybrid Polymer-Schichten (1)
- hybrid ligands (1)
- hybrid polymer coatings (1)
- hybrid polymers (1)
- hydnocarpin (1)
- hydratropyl acetate (1)
- hydrazone (1)
- hydrides (1)
- hydroboration (1)
- hydrodefluorination (1)
- hydrofluorocarbons (1)
- hydrogen (1)
- hydrogen bond (1)
- hydrogen bonding (1)
- hydrogen bonds (1)
- hydrolysis kinetics (1)
- hydroperoxides (1)
- hydrophile Interaktionschromatographie (1)
- hydrophilic interaction chromatography (1)
- hydrophilic polymers (1)
- hydrophosphination (1)
- hyperconjugation (1)
- hyperfine coupling constant (1)
- hypertension (1)
- hypervalency (1)
- hypolipidemic activity (1)
- höherkoordiniertes Germanium (1)
- imaging (1)
- imidazolate (1)
- imide ligands (1)
- imidization (1)
- imido (1)
- iminoboryl complex (1)
- immunisation (1)
- immunoprecipitation (1)
- immunprecipitations (1)
- implant (1)
- improved cyle life (1)
- impurity profile (1)
- impurity profiling (1)
- impurity test (1)
- in silico models (1)
- in vitro selection (1)
- in vitro study (1)
- in vitro-in vivo correlation (1)
- in vitro/in vivo Korrelation (1)
- in vitro/in vivo correlation (1)
- in-vitro-assays (1)
- inclusion complex (1)
- indenyl (1)
- indenyl ruthenium complexes (1)
- inflammatory diseases (1)
- influences of water (1)
- information-theoretical (1)
- infusion solutions (1)
- inhibition of H+ translocation (1)
- inhibitor (1)
- initiation (1)
- initiation of DNA-replication (1)
- initiation proteins of mouse (1)
- injectability (1)
- injectable protein formulation (1)
- innate immunity (1)
- inorganic-organic hybrid polymer (1)
- interacting proteins (1)
- interaction (1)
- interagierende Proteine (1)
- interface (1)
- internal transcribed spacer 2 (1)
- interparticular forces (1)
- interpartikuläre Haftkräfte (1)
- interpretable (1)
- interpretierbar (1)
- intersystem crossing (1)
- intervalence charge transfer (1)
- intervalence charge-transfer (1)
- intestinal availability (1)
- intestinal mucus (1)
- intestinal permeability (1)
- intestinale Verfügbarkeit (1)
- intracellular transport (1)
- intramolecular Michael addition (1)
- intranasal (1)
- intranasal corticosteroids (1)
- intrinsic free space (1)
- inverse Simulation (1)
- inverse thermogels (1)
- ion pairing (1)
- ion-chromatography (1)
- ion-pair chromatography (1)
- ionic liquid (1)
- ionization energy (1)
- ionization potential (1)
- iridium (1)
- iridium complex (1)
- iridiun (1)
- iron (1)
- iron metabolism (1)
- iron oxide (1)
- iron oxide nanoparticles (1)
- irreversibel (1)
- irreversible (1)
- irreversible Inhibitoren (1)
- irreversible inhibitors (1)
- isocyanide multicomponent reactions (1)
- isoelectronic analogues (1)
- isoindolines (1)
- isolated reperfused lung (1)
- isolation (1)
- isomerization (1)
- isonitrile complexes (1)
- isoprostaglandin (1)
- isotopically labelled peptides (1)
- istotope discrimination (1)
- kasA (1)
- kinase Syk (1)
- kinase inhibitor (1)
- kinase inhibitors (1)
- kinetics of thermolysis (1)
- knowledge-based systems (1)
- kohärente anti-Stokessche Raman-Spektroskopie (CARS) (1)
- kohärente anti-Stokessche Raman-Streuung (1)
- kombinatorische Methodenentwicklung (1)
- konfokal Mikro-Raman-Spektroskopie (1)
- konfokale Raman-Mikroskopie (1)
- konfokale Raman-Spektroskopie (1)
- kontinuierliche Ultrafiltration (1)
- koordination chemistry (1)
- kristallin (1)
- kritische Punkte (1)
- künstliche Lichtsammelsysteme (1)
- lH-Cyclopropa[a]naphthalenes (1)
- lactams (1)
- ladungsgetrennte Zustände (1)
- lanthanide complexes (1)
- lanthanides (1)
- laser control (1)
- laser diffraction analysis (1)
- late transition metals (1)
- latex particles (1)
- lattice forces (1)
- layer-by-layer-process (1)
- layered oxides (1)
- layered silicate (1)
- lead optimization (1)
- lead structure optimization (1)
- lectin (1)
- levodopa (1)
- ligand design (1)
- ligand-receptor complex (1)
- light harvesting (1)
- light-induced interstrand DNA crosslinking (1)
- lilial (1)
- linear discriminant analysis (1)
- lipid bilayer (1)
- lipid deterioration (1)
- lipid deterioration markers (1)
- lipids (1)
- liposomes (1)
- lipoxygenase <5-> (1)
- liquid chromatography (1)
- liquid chromatography tandem mass spectrometry (LC-MS/MS (1)
- liquid crystal (1)
- liquid-phase deposition (1)
- lithiumalkyl (1)
- localization (1)
- low-cost spectrometer (1)
- lowering lattice forces (1)
- luminescence based detectors (1)
- lumineszenzbasierte Detektoren (1)
- lung perfusion model (1)
- lysosome (1)
- m-RNA (1)
- mRNA level (1)
- mRNA-Metabolismus (1)
- mRNA-Spiegel (1)
- machineability (1)
- macroarray (1)
- macrophage (1)
- macrophage infectivity potentiator (1)
- macrophage infectivity potentiator protein (1)
- magnetic particles (1)
- magnetic resonance imaging (1)
- magnetic resonance imaging (MRI) (1)
- magnetic separation (1)
- main binding determinant (1)
- main-group metals (1)
- male size polymorphism (1)
- mammary gland (1)
- mannich reaction (1)
- manufacturer (1)
- mao-inhibiters (1)
- marine bacteria (1)
- marine fungi (1)
- marine macroalgae (1)
- marine natural product (1)
- marine natural products (1)
- marine sponges (1)
- mass balance (1)
- measles virus (1)
- measurement of humidity (1)
- mechanical properties (1)
- mechanical reinforcement (1)
- mechanical spectroscopy (1)
- mechanische Eigenschaften (1)
- mechanistic drug-drug interactions (1)
- mechanistic studies (1)
- mechanistische Arzneistoffinteraktionen (1)
- mechanochemical degradation (1)
- melanoma (1)
- melanoma ; oncogene regulation ; esterase ; molecular marker sequences (1)
- melatonin (1)
- melatonin analogues (1)
- melatonin receptor ligands (1)
- mercapturic acids (1)
- merocyanine (1)
- merocyanine dye (1)
- merocyanine dyes/pigments (1)
- mesogens (1)
- mesoporous silica (1)
- mesoporöse Silica (1)
- meta-Iodbenzylguanidin (1)
- meta-iodobenzylguanidine (1)
- metabolic analysis (1)
- metabolic network (1)
- metabolic syndrome (1)
- metabolisches Netzwerk (1)
- metabolite (1)
- metabolomics (1)
- metabonomics (1)
- metaheuristic methods (1)
- metal coordination (1)
- metal organic (1)
- metal-ion-ligand coordination (1)
- metal-organic framework (1)
- metall-matrix-composite (1)
- metallfreie Porphyrine (1)
- metallic (1)
- metallisch (1)
- metallo-phosphines (1)
- metallo-silanols (1)
- metallo-siloxanes (1)
- metallo-supramolecular polymer (1)
- metalloarenophanes (1)
- metallocenes (1)
- metallosupramolecular π-amphiphiles (1)
- metathesis (1)
- methyl viologen (1)
- methylanthranilate (1)
- methyllithium (1)
- methyltransferase (1)
- mica (1)
- micro Raman spectroscopy (1)
- microemulsion (1)
- microorganisms (1)
- microphase separation (1)
- microprobe analysis (1)
- microspheres (1)
- mikroorganisms (1)
- mineralization (1)
- mini-exon (1)
- mixed valence compunds (1)
- mixed-valence compound (1)
- mixing conditions (1)
- mode of action (1)
- model binding site (1)
- modelling of a spiral jet mill (1)
- modified nucleosides (1)
- modulating (1)
- molecular biopharmaceutics (1)
- molecular capsules (1)
- molecular docking (1)
- molecular dynamic (1)
- molecular dynamics simulations (1)
- molecular properties (1)
- molecular switch (1)
- molecular switches (1)
- molecular systematics (1)
- molekulare Eigenschaften (1)
- molekulare Erkennung (1)
- molekulare Schalter (1)
- molekularer Schalter (1)
- molekulares Modellieren (1)
- monoamine oxidase (1)
- monocyte (1)
- monocytes (1)
- mtrogen extruston (1)
- mucin (1)
- multi-photon processes (1)
- multichromophoric arrays (1)
- multicomponent Ugi-type reaction (1)
- multicomponent drugs (1)
- multicore particles (1)
- multicycle CEP control (1)
- multifunctional nanoparticles (1)
- multilevel luminescence identification (1)
- multimodal imaging (1)
- multiphoton spectroscopy (1)
- multiple bonds (1)
- multiple linear regression (1)
- murine (1)
- muscarinic (1)
- muscarinic M1 receptor (1)
- muscarinic acetylcholine receptor (1)
- muscarinic acetylcholine receptors (1)
- mva (1)
- mycobacterium tuberculosis (1)
- mycotoxin (1)
- mycotoxins (1)
- nacreous layer formation (1)
- nano LDH (1)
- nano particle (1)
- nano rods (1)
- nano-material (1)
- nano-particle (1)
- nanocavities (1)
- nanographene (1)
- nanomateriales (1)
- nanomaterials (1)
- nanomedicine (1)
- nanoparticle aggregation (1)
- nanoparticle synthesis (1)
- nanophotonics and plasmonics (1)
- nanoporous (1)
- nanosegregation (1)
- nanotherapeutics (1)
- nanotopography (1)
- naphthalenes (1)
- naphthoquinone (1)
- naphthyl isoquinoline alkaloids (1)
- naphthylisoquinolines (1)
- napthalene diimide (1)
- napthylisoquinoline alkaloids (1)
- narrow bandwidth (1)
- native chemical ligation (1)
- natural ligands (1)
- natürliche Liganden (1)
- nephrotoxicity (1)
- network chain length (1)
- neue Inhibitorklasse (1)
- neue Verunreinigungen (1)
- neue metallorganische Komplexe (1)
- neurodegenerative diseases (1)
- neuromelanin (1)
- neuroprotective (1)
- neuroprotectivity (1)
- neurotoxine (1)
- neutral polyradical (1)
- neutrales Polyradikal (1)
- new impurities (1)
- new inhibitor class (1)
- new organometallic complexes (1)
- nicht kovalente Wechselwirkungen (1)
- nicht-adiabatische Effekte (1)
- nicht-invasiv (1)
- nicht-lineare Optik (1)
- nichtadiabatische Kopplung (1)
- nichtlineare Optik (1)
- nichtpeptidische Inhibitoren (1)
- niederdimensionale Halbleiter (1)
- niedermolekularer Inhibitor (1)
- niedervalent (1)
- niobium (1)
- nitric oxide (1)
- nitrogen ligands (1)
- nitrogen trichloride (1)
- non covalent interactions (1)
- non-fullerene acceptors (1)
- non-invasive (1)
- non-linear optics (1)
- non-peptidic inhibitors (1)
- non-racemic (1)
- nonadiabatic coupling (1)
- nonadiabatic effects (1)
- nonlinear optics (1)
- nonlinear spectroscopy (1)
- non‐classical crystallization (1)
- noradrenaline (1)
- notch (1)
- novel nepetolactone derivative (1)
- nuclear magnetic resonance spectroscopy (1)
- nucleating agents (1)
- nucleic acid (1)
- nucleobases (1)
- nucleophile (1)
- nucleophilic addition (1)
- nucleophilic aromatic substitution (1)
- nucleophilic substitution (1)
- o-Quinodimethane (1)
- o-methoxy-sila-hexocyclium (1)
- obstructive pulmonary disease (1)
- odorant (1)
- odourants (1)
- olefin polymerization (1)
- oligo(phenylene ethynylene) (OPE) (1)
- oligothiophene (1)
- olive oil (1)
- olyelectrolyte domains (1)
- onbead enzym screening (1)
- one-electron oxidation (1)
- ontologies (1)
- operando-Messung (1)
- ophthalmic (1)
- opioid ligands (1)
- opioid receptors (1)
- optical gradient trap (1)
- optical nonlinearity 2. order (1)
- optical properties (1)
- optically active (1)
- optically active hydroperoxides (1)
- optically active phase-transfer catalysts (1)
- optisch aktive Hydroperoxide (1)
- optisch aktive Phasentransferkatalysatoren (1)
- optische Eigenschaften (1)
- optische Nichtlinearität 2. Ordnung (1)
- oral lyophilisate (1)
- orale Bioverfügbarkeit (1)
- orbital diagram (1)
- organelle (1)
- organic and inorganic synthesis (1)
- organic interfaces (1)
- organic light emitting diodes (1)
- organic photodiodes (1)
- organic photovoltaics (1)
- organic sythesis (1)
- organische Chemie (1)
- organische Grenzflächen (1)
- organische Photovoltaik (1)
- organische Solarzellen (1)
- organische Synthese (1)
- organischer Feldeffekttransistor (1)
- organoboron (1)
- organocatalysis (1)
- organocatalytic (1)
- organometal complexes (1)
- oriented attachment (1)
- origin (1)
- ortho-Phthaldialdehyd (1)
- ortho-phthaldialdehyd (1)
- orthogonal self-assembly (1)
- osimertinib (1)
- osteochondral implant (1)
- oxidative Addition (1)
- oxidative Stressmarker (1)
- oxidative stress (1)
- oxidative stress marker (1)
- oxo anion recognition (1)
- oxoboryl complex (1)
- oxofunctionalization (1)
- oxygenation (1)
- p-Fluoro-hexahydro-sila-difenidol (1)
- p-Halbleiter (1)
- p-fluoro-hexahydro- (1)
- p97 (1)
- paclitaxel (1)
- palladium-catalyzed (1)
- paraffins (1)
- parallel imaging (1)
- paramagnetisch (1)
- parasitic (1)
- parasitär (1)
- parkinson (1)
- particle (1)
- particle surface (1)
- particles (1)
- pectins (1)
- pentacene (1)
- pentacoordinate silicon (1)
- pentacoordination (1)
- pentakoordinierte (1)
- pentenol (1)
- peptide conjugates (1)
- peptide stapling (1)
- peptidomimetic (1)
- peptidomimetic sequence (1)
- peptidomimetisch (1)
- peptoid (1)
- perfluoroalkyl (1)
- perfluoroarylation (1)
- perfumes (1)
- pericyclic reaction (1)
- peroxide containing copolymers (1)
- peroxyl (1)
- perylene (1)
- perylene bisimide dyes (1)
- perylene bisimide hydrogels (1)
- perylene bisimides (1)
- perylene dyes (1)
- perylene imide (1)
- pflanzliche Zellkerne (1)
- pharmaceutical analysis (1)
- pharmaceutical care (1)
- pharmaceuticals (1)
- pharmacodynamic (1)
- pharmacogenetics (1)
- pharmacology (1)
- pharmacometrics (1)
- pharmacy (1)
- pharmakologisches Profil (1)
- phase-solubility (1)
- phenazine (1)
- phenolic acids (1)
- phenotyping (1)
- phenyl-substituted (1)
- phenylboronate (1)
- phenylethylamine (1)
- phosphanes (1)
- phosphatases (1)
- phosphenium (1)
- phosphine (1)
- phosphinidene (1)
- phosphoantigens (1)
- phosphodiesterase-4 inhibitor (1)
- phosphorescence (1)
- phosphorus (1)
- phosphorylation (1)
- phosphorylation sites (1)
- phosporus ylides (1)
- photoactivation (1)
- photochemical (1)
- photochemical processes (1)
- photochemische Prozesse (1)
- photochemistry (1)
- photochromism (1)
- photoconductivity (1)
- photocontrol (1)
- photodynamic therapy (1)
- photoelectron-photoion coincidence (1)
- photoinduzierter Elektronentransfer (1)
- photonic crystal (1)
- photonic devices (1)
- photopharmacology (1)
- photorefractivity (1)
- phylogenetic tree (1)
- phylogeny (1)
- physical hydrogels (1)
- phytoestrogens (1)
- phytopathogens (1)
- pi-pi Wechselwirkungen (1)
- pi-pi interaction (1)
- pi-pi- stacking (1)
- pi-pi-Wechselwirkung (1)
- pig (1)
- pig-caecum-model (1)
- pine bark extract (1)
- pipecolic acid derivatives (1)
- piperidin alcaloids (1)
- piperidines (1)
- pitot tube (1)
- placenta (1)
- plant cell culture (1)
- plant extracts (1)
- plant nuclei (1)
- plasma protein binding (1)
- plastids (1)
- platelet receptor (1)
- platinum (1)
- platinum complex (1)
- platinum complexes (1)
- pn-Übergang (1)
- podophyllotoxin (1)
- podoplanin (1)
- pol(2-oxazoline) (1)
- polar solution (1)
- polare Lösung (1)
- polarisation pulse shaping (1)
- polarized low wavenumber Raman spectroscopy (1)
- polarizing optical microscopy (1)
- pollen (1)
- poly(2- oxazoline) (1)
- poly(2-oxazine)s (1)
- poly(dimethylsiloxane) (1)
- poly(lactic-co-glycolic acid) (1)
- polyamine (1)
- polyamine pathway (1)
- polycaprolactone (1)
- polycarbazole (1)
- polycyclic (1)
- polycyclic aromatic hydrocarbon (1)
- polyelectrolyte domains (1)
- polyethylenglykole (1)
- polyketides (1)
- polylactid (1)
- polymer (1)
- polymerase (1)
- polyoxazolines (1)
- polypeptoids (1)
- polysiloxane (1)
- poor water-soluble drugs (1)
- poorly water soluble (1)
- poorly water soluble drugs (1)
- porcellain (1)
- porous materials (1)
- porphyrin (1)
- porphyrin chemistry (1)
- positron (1)
- positron annihilation lifetime spectroscopy (1)
- positron emission tomography (1)
- postpolymerization modification (1)
- postsurgical adhesion (1)
- posttranscriptional modification (1)
- posttranskriptionale Modifikation (1)
- powder (1)
- pp6oc-src (1)
- pre-replicative complex (1)
- pre-tRNA Spleißen (1)
- pre-tRNA splicing (1)
- preRC (1)
- premix (1)
- prereplicative complex (1)
- pressure (1)
- primary phosphine complexes (1)
- principal component analysis (1)
- pro-inflammatory cytokines (1)
- probe (1)
- procambarus-clarkii (1)
- process of solution (1)
- procyanidins (1)
- profiles (1)
- proliferation (1)
- proline (1)
- promoter (1)
- promoter polymorphism (1)
- propargyl (1)
- propionate (1)
- propolis (1)
- proppins (1)
- protease-sensitive release (1)
- protecting group (1)
- protein adducts (1)
- protein adsorption (1)
- protein corona (1)
- protein crystallization (1)
- protein crystallography (1)
- protein design (1)
- protein ligand interactions (1)
- protein modification (1)
- protein nebulization (1)
- protein sensing (1)
- protein therapeutics (1)
- protein-ligand-interaction (1)
- protein-protein-interaction (1)
- protein-protein-interactions (1)
- proteins (1)
- proteome (1)
- präRC (1)
- pseudodistomine C (1)
- pulmonal (1)
- pump-CARS (1)
- pump-probe-spectroscopy (1)
- purine (1)
- purity control (1)
- push-pull stabilization (1)
- push–pull thienylthiazole (1)
- pyracene (1)
- pyrazine (1)
- pyrene (1)
- pyridine (1)
- pyrimidines (1)
- pyroglutamic acid (1)
- pyrrolidine (1)
- pyrrolizidine alkaloid N-oxide (1)
- pyrrolizidine alkaloids (1)
- qNMR (1)
- qsar (1)
- quantification (1)
- quantitativ (1)
- quantitative (1)
- quantitative NMR spectroscopy (1)
- quantum dots (1)
- quinolizinium salts (1)
- quinolones (1)
- quinone oxidoreductase (1)
- rBAM2-labeled RNA strands (1)
- racemization (1)
- radical crosslinking (1)
- radiosynthesis (1)
- radiotracers (1)
- rare earth doped nanoparticles (1)
- rat study (1)
- rat) (1)
- reabsorption (1)
- reaction mechanism (1)
- reaction mechanisms (1)
- reaction-diffusion-systems (1)
- reactive metabolites (1)
- reactivity and selectivity study (1)
- reaktive Intermediate (1)
- reaktive Metabolite (1)
- real-time NMR spectroscopy (1)
- rearrangement (1)
- receptor antagonists (1)
- receptor-regulation (1)
- recognition (1)
- recovery aroma (1)
- redox (1)
- redox chemistry (1)
- redox-active ligands (1)
- refractive index (1)
- relation (1)
- relativistic (1)
- relativistisch (1)
- relaxation (1)
- relaxivity (1)
- replica-exchange molecular dynamics (1)
- required hydrophilic–lipophilic balance (1)
- residence time (1)
- resonance Raman scattering (1)
- resources recovery (1)
- retinobalstoma protein (1)
- reversible Verkapselung (1)
- reversible encapsulation (1)
- rhenium (1)
- rheology (1)
- ribosomal RNA (1)
- ribozyme (1)
- rigidification (1)
- ring expansion (1)
- ring opening polymerization (1)
- ring opening reactions (1)
- ring strain (1)
- ring-expansion reaction (1)
- roast coffee (1)
- rocket salad (1)
- rod-to-sphere transition (1)
- rofumilast (1)
- ruthenium thioaldehyde complexes (1)
- s-block metals (1)
- sDMA (1)
- sacha inchi oil (1)
- salt metathesis (1)
- scanner (1)
- scanning probe microscopy (1)
- schizophrenia (1)
- schwach gekoppelte Regime (1)
- schwefelhaltige Aromastoffe (1)
- schwer wasserlöslich (1)
- scoring functions (1)
- seagrass (1)
- secondary metabolites (1)
- secondary structures (1)
- secreted aspartic proteases (1)
- secretion (1)
- security tags (1)
- sekretorische Aspartatproteasen (1)
- selbst organisierende Monolagen (SAM) (1)
- selbstaggregierten (1)
- selectivity (1)
- selenolysis (1)
- self-assembled monolayer (SAM) (1)
- self-sorting (1)
- self-trapping (1)
- semantic technologies (1)
- semiconducting polymers (1)
- semiconductor devices (1)
- semiconductor nanostructures (1)
- sensor supports (1)
- separation techniques (1)
- sexual selection (1)
- shape fidelity (1)
- shape-amphiphiles (1)
- shear thinning (1)
- shellac (1)
- signaltransduction (1)
- sila-analogue (1)
- sila-drugs (1)
- sila-subsitution (1)
- sila-substitution (1)
- silahexocyclium (1)
- silanes (1)
- silanol (1)
- silica supraparticles (1)
- silicate (1)
- silicates (1)
- siliciumhaltige Chelatliganden (1)
- siliciumorganisch (1)
- siliciumorganische Verbindungen (1)
- silicon complexes (1)
- silicon-containing chelate ligands (1)
- silk fibroin (1)
- silk fibroin scaffolds (1)
- siloxane (1)
- siloxanes (1)
- silver (1)
- silybin (1)
- silyl selenides (1)
- silyl sulfides (1)
- simple (1)
- simple repeat sequences (1)
- simple repetitive sequences (1)
- simulation (1)
- single crystal structure (1)
- single particle microscopy (1)
- single-molecule microscopy (1)
- single-wall carbon nanotube (1)
- single-wall carbon nanotubes (1)
- sisomicin (1)
- site-specific protein modification (1)
- six-membered (1)
- size polymorpbism (1)
- skin whitening (1)
- slurry composition (1)
- small molecule inhibitor (1)
- small-molecule activation (1)
- smart material (1)
- smart surfaces (1)
- snRNP (1)
- social self‐sorting (1)
- sodal domlnance (1)
- sol-gel chemistry (1)
- sol-gel process (1)
- solar cell (1)
- solid dispersion (1)
- solid state (1)
- solid state NMR spectroscopy (1)
- solid-state NMR (1)
- solid-state emitters (1)
- solid-state sturcture (1)
- solid‐state emission (1)
- solvolysis of (1)
- somatostatin receptor subtype 4 (1)
- sorbitol-fermenters (1)
- sortase A (1)
- sp2-sp3 (1)
- sp2-sp3 Diborane (1)
- sp2-sp3 diboranes (1)
- sparteine (1)
- spectrofluorimetry (1)
- spermine (1)
- spin chemistry (1)
- spirooxazine (1)
- spiropiperidines (1)
- spray (1)
- spray‐drying (1)
- späte Übergangsmetalle (1)
- squalene (1)
- stability (1)
- star-shaped compounds (1)
- starazine (1)
- starphene analogue (1)
- static mixer (1)
- stealth fluorophores (1)
- steered molecular dynamics (1)
- stent (1)
- step-growth polymerization (1)
- stereochemistry (1)
- stereoselective Transesterification (1)
- stereoselective interaction (1)
- stereoselective syntheses (1)
- stereoselectivity (1)
- sterisch anspruchsvolle Liganden (1)
- sterubin (1)
- stibine (1)
- stochastic resonance (1)
- stochastische Schrödingergleichung (1)
- strawberry (1)
- streptomyces (1)
- structural biology (1)
- structure (1)
- structure property relationship (1)
- structure-based drug design (1)
- structure–activity (1)
- structure–property relation (1)
- strychnine (1)
- substituent (1)
- substituted (1)
- substituted 2-oxo- dimethyl esters (1)
- substrate binding (1)
- subtractive-methods (1)
- subtype selectivity (1)
- subtypes of (1)
- sugar phosphate (1)
- sulfoxidation (1)
- sulfur containing flavour compounds (1)
- sulfur donor (1)
- sun screening (1)
- superparamagnetism (1)
- supramolecular Chemistry (1)
- supramolecular capsules (1)
- supramolekulare Kapseln (1)
- supramolekularen Elektronik (1)
- surface (1)
- surface coverage (1)
- surface functionalisation (1)
- surface functionalization (1)
- surface modification (1)
- surface modifications (1)
- surface roughness (1)
- swallow-tail (1)
- synchrotron radiatoren (1)
- syntheses (1)
- synthesis process (1)
- synthesis silicon (1)
- synthetic methods (1)
- synthetic polypeptides (1)
- tRNA Ligase (1)
- tRNA Reparatur (1)
- tRNA ligase (1)
- tRNA repair (1)
- tablets (1)
- tacrine (1)
- tandem mass spectrometry (1)
- tandem-Wittig-1 (1)
- tantalum (1)
- tape casting (1)
- teleost flsh (1)
- template catalysis (1)
- tensile strength tester (1)
- tensile strengths (1)
- terminal differentiation (1)
- terminale Differenzierung (1)
- terphenyl derivatives (1)
- tetracoordinated boron (1)
- tetrahydrofuran (1)
- tetrahydrofurans (1)
- thalidomide (1)
- theoretical characterisation (1)
- theoretical investigations (1)
- theoretische Untersuchungen (1)
- therapeutic drug monitoring (1)
- therapeutic gases (1)
- therapeutic strategy (1)
- therapeutisches Target (1)
- thermal conductivity (1)
- thermal crosslinking (1)
- thermal stability (1)
- thermodynamic (1)
- thermogelling (1)
- thermolysis (1)
- thiirane (1)
- thiirenium ion (1)
- thin film (1)
- thin films (1)
- thiocinnamaldehyde (1)
- thiolate-ligands (1)
- thiolysis (1)
- thiopyran (1)
- threshold photoelectron photoion coincidence (1)
- time-dependent density functional theory (1)
- time-resolved optical spectroscopy (1)
- timololmaleate (1)
- tissue regeneration (1)
- tofacitinib (1)
- toll-like receptors (1)
- topological analysis (1)
- topologische Analyse (1)
- toxicokinetics (1)
- toxicological properties (1)
- trace elements (1)
- trans influence (1)
- trans-Einfluss (1)
- transcription (1)
- transcriptome (1)
- transformation toughening (1)
- transgenic fish (1)
- transglutaminase (1)
- transient spectroscopy (1)
- transition metal boron complexes (1)
- transition state (1)
- translation (1)
- translationally and rotationally invariant (1)
- translations- und rotationsinvariant (1)
- transport (1)
- trap (1)
- treatment regimens (1)
- triacylglycerides (1)
- triaryalmine (1)
- triarylamines (1)
- tricalcium phosphate (1)
- trichloroethylene (1)
- trifluoropropionic acid (1)
- triparanol (1)
- triplet (1)
- triplet sensitization (1)
- tropische Infektionskrankheiten (1)
- truxenone (1)
- tuberculosis (1)
- tumor suppressor gene (1)
- tweezer receptors (1)
- two-dimensional (1)
- two-hybrid-system (1)
- two-photon excited fluorescence (1)
- tyrosinase (1)
- tyrosine-protein kinase (1)
- ultrafast Raman loss spectroscopy (1)
- underutilized legumes (1)
- ungesättigte Komplexe (1)
- unsaturated complexes (1)
- unsaturated fatty acids (1)
- unstructured proteins (1)
- upconversion (1)
- uremic toxins (1)
- vaccination (1)
- vaccinia (1)
- vacuum processable (1)
- valtrates (1)
- van der Waals Clustern (1)
- van der Waals clusters (1)
- vanadium(V)- and cobalt(II)-catalyzed oxidation (1)
- vancomycin (1)
- vasculogenesis (1)
- velocity (1)
- venlafaxine (1)
- verbesserte Zyklenfestigkeit (1)
- verbrückend (1)
- verzögerte Fluoreszenz (1)
- vesicle (1)
- vibrational spectroscopy (1)
- vier Wellen Mischen Spektroskopie (1)
- vif (1)
- vinylidene complexes (1)
- wR factor = 0.052 (1)
- wR factor = 0.068 (1)
- wR factor = 0.069 (1)
- wallpainting (1)
- warhead (1)
- water oxidation (1)
- water oxidation reation (1)
- watersolubility (1)
- weak coupling regime (1)
- weakly coordinating anions (1)
- wässrig (1)
- xanthine (1)
- xenoestrogens (1)
- xylylene (1)
- y-Oxoketenes (1)
- young’s modulus (1)
- zebrafish (1)
- zeitabhängige Dichtefunktionaltheorie (1)
- zeitaufgelöste Spektroskopie (1)
- zetapotential (1)
- zinc chlorins. (1)
- zooxanthellae (1)
- zweidimensional (1)
- zwitterionic spirosilicate (1)
- zwitterionic λ5-Spirosilicates (1)
- zwitterionische (1)
- HILIC (1)
- Ölsäure (1)
- Übergangselemente (1)
- Übergangsmetall-Komplexe (1)
- Übergangsmetallborylen, Borylentransfer, Basenstabilisiertes Borylen, Metathese (1)
- Übergangsmetalle (1)
- Übergangsmetallorganische Verbindungen (1)
- ß-Carbolinalkaloide, 7-Alkyloxycumarine, Clopidogrel, Paracetamol (1)
- ß-Carboline (1)
- ß-Lactones (1)
- ß-carboline alkaloids, 7-alkyloxycoumarins, clopidogrel, acetaminophen (1)
- ß-carbolines (1)
- ß-unsaturated (1)
- ätherische Öle (1)
- α-aminoboronates (1)
- β-Lactones (1)
- β2 - Agonisten (1)
- β2 - agonist (1)
- δ-Lactones (1)
- δ-chloro- (1)
- π aromaticity (1)
- π-Aromatizität (1)
- π-complex (1)
- π-extension (1)
Institute
- Institut für Anorganische Chemie (389)
- Institut für Organische Chemie (341)
- Institut für Pharmazie und Lebensmittelchemie (286)
- Institut für Physikalische und Theoretische Chemie (116)
- Theodor-Boveri-Institut für Biowissenschaften (85)
- Institut für Funktionsmaterialien und Biofabrikation (66)
- Lehrstuhl für Biochemie (32)
- Fakultät für Chemie und Pharmazie (28)
- Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde (24)
- Institut für Pharmakologie und Toxikologie (19)
Sonstige beteiligte Institutionen
- Fraunhofer-Institut für Silicatforschung ISC (4)
- Fraunhofer-Institut für Silicatforschung (2)
- ACC GmbH Analytical Clinical Concepts (1)
- Bayer AG, Research & Development, Pharmaceuticals, Investigational Toxicology (1)
- Bayerisches Geoinstitut, Universität Bayreuth (1)
- Center for Nanosystems Chemistry (1)
- Center for Nanosystems Chemistry (CNC), University of Würzburg (1)
- Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells, Göttingen (1)
- Department of Cellular Biochemistry, University Medical Center Göttingen (1)
- Department of Cellular Biochemistry, University Medical Centre Göttingen (1)
ResearcherID
- B-1911-2015 (1)
- N-3741-2015 (1)
Site-directed bioorthogonal conjugation techniques have substantially advanced research in numerous areas. Their exceptional value reflects in the extent of applications, that have been realized with spacial-controlled bioorthogonal reactions. Specific labeling of surfaces, proteins, and other biomolecule allows for new generations of drug delivery, tracking, and analyzing systems. With the continuous advance and refinement of available methods, this field of research will become even more relevant in the time to come. Yet, as individual as the desired purpose is, as different can be the most suitable modification strategy. In this thesis, two different bioconjugation approaches, namely CuAAC and factor XIIIa mediated ligation, are used in distinct application fields, featuring eGFP as a model protein showcasing the advantages as well as the challenges of each technique.
The introduction of a unique accessible functionality is the most critical feature of a site-specific reaction, and the first considerable hurdle to clear. While most surfaces, peptides, or small molecules might require less expenditure to modulate, equipping large biomolecules like proteins with additional traits requires careful consideration to preserve the molecule’s stability and function. Therefore, the first section of this project comprises the engineering of eGFP via rational design. Initially, wild-type eGFP was subcloned, expressed, and characterized to serve as a reference value for the designed variants. Subsequently, eGFP was mutated and expressed to display a recognition site for factor XIIIa. Additionally, a second mutant harbored a TAG-codon to enable amber codon suppression and consequently the incorporation of the alkyne bearing unnatural amino acid Plk to support a CuAAC reaction. Fluorescence spectroscopy was used to confirm that the fluorescent properties of all expressed muteins were identically equal to wild-type eGFP, which is a reliable marker for the intact barrel structure of the protein. Trypsin digestion and HPLC were deployed to confirm each protein variant's correct sequence and mass.
The second part of this work focuses on the conjugation of cargo molecules deploying the chosen approaches. Solid-phase peptide synthesis was used to create a peptide that served as a lysine donor substrate in the crosslinking mechanism of FXIIIa. Additionally, the peptide was provided with a cysteine moiety to allow for highly flexible and simple loading of desired cargo molecules via conventional thiol-Michael addition, thus establishing an adaptive labeling platform. The effective ligation was critically reviewed and confirmed by monitoring the exact mass changes by HPLC. Protocols for attaching payloads such as biotin and PEG to the linker peptide were elaborated. While the biotin construct was successfully conjugated to the model protein, the eGFP-PEG linkage was not achieved judging by SDS-PAGE analysis. Furthermore, featuring isolated peptide sequences, the properties of the FXIIIa-mediated reaction were characterized in detail. Relative substrate turnover, saturation concentrations, by-product formation, and incubation time were comprehensively analyzed through HPLC to identify optimal reaction conditions. CuAAC was successfully used to label the Plk-eGFP mutein with Azide-biotin, demonstrated by western blot imaging.
Within the last part of this study, the application of the conjugation systems was extended to different surfaces. As regular surfaces do not allow for immediate decoration, supplementary functionalization techniques like gold-thiol interaction and silanization on metal oxides were deployed. That way gold-segmented nanowires and Janus particles were loaded with enoxaparin and DNA, respectively. Nickel and cobalt nanowires were modified with silanes that served as linker molecules for subsequent small molecule attachment or PEGylation. Finally, the eGFP muteins were bound to a particle surface in a site-specific manner. Beads displaying amino groups were utilized to demonstrate the effective use of FXIIIa in surface modification. Moreover, the bead’s functional moieties were converted to azides to enable CuAAC “Click Chemistry” and direct comparison. Each modification was analyzed and confirmed through fluorescence microscopy.
The aim of the present work was to improve drug monitoring in patients with various diseases in the context of precision medicine. This was pursued through the development and validation of mass spectrometric methods for determining the drug concentrations of kinase inhibitors and their clinical application. Besides conventional approaches to determine plasma level concentrations, the focus was also on alternative sampling techniques using volumetric absorptive microsampling (VAMS).
A conventional LC-MS/MS method was developed for the determination of cabozantinib in human EDTA plasma and validated according to the guidelines of the European and United States drug authorities (EMA, FDA). The method met the required criteria for linearity, accuracy and precision, selectivity, sensitivity, and stability of the analyte. Validation was also performed for dilution integrity, matrix effect, recovery, and carry-over, with results also in accordance with the requirements. The importance of monitoring the exposure of cabozantinib was demonstrated by a clinical case report of a 34-year-old female patient with advanced adrenocortical carcinoma who also required hemodialysis due to chronic kidney failure. Expected cabozantinib plasma concentrations were simulated for this off-label use based on a population pharmacokinetic model. It was shown that the steady state trough levels were much lower than expected but could not be explained by hemodialysis. Considering the critical condition and potential drug-drug interaction with metyrapone, a substance the patient had taken among several others during the observation period, individual pharmacokinetics could consequently not be estimated without drug monitoring.
In addition, a VAMS method for simultaneous determination of ten kinase inhibitors from capillary blood was developed. This microsampling technique was mainly characterized by the collection of a defined volume of blood, which could be dried and subsequently analyzed. The guidelines for bioanalytical method validation of the EMA and FDA were also used for this evaluation. As the nature of dried blood samples differs from liquid matrices, further parameters were investigated. These include the investigation of the hematocrit effect, process efficiency, and various stability conditions, for example at increased storage temperatures. The validation showed that the developed method is suitable to analyze dried matrix samples accurate, precise, and selective for all analytes. Apart from the stability tests, all acceptance criteria were met. The decreased stability of two analytes was probably due to the reproducible but reduced recovery. In vitro studies provided results on the VAMS-to-plasma correlation to predict the analyte distribution between both matrices, at least in an exploratory manner. It revealed a heterogeneous picture of analytes with different VAMS-to-plasma distributions. Furthermore, the analysis of 24 patient samples indicated the applicability of at-home VAMS. Both should be confirmed later as part of the clinical validation.
The clinical investigation of the VAMS method pursued two objectives. On the one hand, the simultaneous collection of VAMS and serum samples should enable a conversion of the determined concentrations and, on the other hand, the feasibility of autonomous microsampling at home should be examined more closely. For the former, it could be shown that different conversion methods are suitable for converting VAMS concentrations into serum levels. The type of conversion was secondary for the prediction. However, the previously defined criteria could not be fulfilled for all five kinase inhibitors investigated. The framework conditions of the study led to increased variability, especially for analytes with short half-life. A low and varying hematocrit, caused by the underlying disease, also made prediction difficult for a specific patient collective. For the second objective, investigating the feasibility of VAMS, different aspects were considered. It could be shown that the majority of patients support home-based microsampling. The acceptance is likely to increase even further when microsampling is no longer part of a non-interventional study, but participation is accompanied by targeted monitoring and subsequent adjustment of the therapy. The fact that additional training increases understanding of the correct sampling procedure is also a source of confidence. Demonstrated stability during storage under real-life conditions underlines the practicality of this sampling technique.
Taken together, mass spectrometric methods for both plasma and VAMS could be developed and validated, and their clinical application could be successfully demonstrated. The availability of simple bioanalytical methods to determine kinase inhibitor exposure could improve access to prospective studies and thus facilitate the implementation of routine therapeutic drug monitoring.
Staphylococcus epidermidis, the common inhabitant of human skin and mucosal surfaces has emerged as an important pathogen in patients carrying surgical implants and medical devices. Entering the body via surgical sites and colonizing the medical devices through formation of multi-layered biofilms leads to refractory and persistent device-related infections (DRIs). Staphylococci organized in biofilms are more tolerant to antibiotics and immune responses, and thus are difficult-to-treat. The consequent morbidity and mortality, and economic losses in health care systems has strongly necessitated the need for development of new anti-bacterial and anti-biofilm-based therapeutics. In this study, we describe the biological activity of a marine sponge-derived Streptomyces sp. SBT348 extract in restraining staphylococcal growth and biofilm formation on polystyrene, glass, medically relevant titan metal, and silicone surfaces. A bioassay-guided fractionation was performed to isolate the active compound (SKC3) from the crude SBT348 extract. Our results demonstrated that SKC3 effectively inhibits the growth (MIC: 31.25 \(\mu\)g/ml) and biofilm formation (sub-MIC range: 1.95-<31.25 \(\mu\)g/ml) of S. epidermidis RP62A in vitro. Chemical characterization of SKC3 by heat and enzyme treatments, and mass spectrometry (HRMS) revealed its heat-stable and non-proteinaceous nature, and high molecular weight (1258.3 Da). Cytotoxicity profiling of SKC3 in vitro on mouse fibroblast (NIH/3T3) and macrophage (J774.1) cell lines, and in vivo on the greater wax moth larvae Galleria mellonella revealed its non-toxic nature at the effective dose. Transcriptome analysis of SKC3 treated S. epidermidis RP62A has further unmasked its negative effect on central metabolism such as carbon flux as well as, amino acid, lipid, and energy metabolism. Taken together, these findings suggest a potential of SKC3 as a putative drug to prevent staphylococcal DRIs.
Understanding relationships between microstructure and electrical transport is an important goal for the materials science of organic semiconductors. Combining high-resolution surface potential mapping by scanning Kelvin probe microscopy (SKPM) with systematic field effect transport measurements, we show that step edges can trap electrons on the surfaces of single crystal organic semiconductors. n-type organic semiconductor crystals exhibiting positive step edge surface potentials display threshold voltages that increase and carrier mobilities that decrease with increasing step density, characteristic of trapping, whereas crystals that do not have positive step edge surface potentials do not have strongly step density dependent transport. A device model and microelectrostatics calculations suggest that trapping can be intrinsic to step edges for crystals of molecules with polar substituents. The results provide a unique example of a specific microstructure–charge trapping relationship and highlight the utility of surface potential imaging in combination with transport measurements as a productive strategy for uncovering microscopic structure–property relationships in organic semiconductors.
Over the years, hydrogels have been developed and used for a huge variety of different applications ranging from drug delivery devices to medical products. In this thesis, a poly(2-methyl-2-oxazoline) (POx) / poly(2-n-propyl-2-oxazine) (POzi) bioink was modified and analyzed for the use in biofabrication and targeted drug delivery. In addition, the protein fibrinogen (Fbg) was genetically modified for an increased stability towards plasmin degradation for its use as wound sealant.
In Chapter 1, a thermogelling, printable POx/POzi-based hydrogel was modified with furan and maleimide moieties in the hydrophilic polymer backbone facilitating post-printing maturation of the constructs via Diels-Alder chemistry. The modification enabled long-term stability of the hydrogel scaffolds in aqueous solutions which is necessary for applications in biofabrication or tissue engineering. Furthermore, we incorporated RGD-peptides into the hydrogel which led to cell adhesion and elongated morphology of fibroblast cells seeded on top of the scaffolds. Additional printing experiments demonstrate that the presented POx/POzi system is a promising platform for the use as a bioink in biofabrication.
Chapter 2 highlights the versatility of the POx/POzi hydrogels by adapting the system to a use in targeted drug delivery. We used a bioinspired approach for a bioorthogonal conjugation of insulin-like growth factor I (IGF-I) to the polymer using an omega-chain-end dibenzocyclooctyne (DBCO) modification and a matrix metalloprotease-sensitive peptide linker. This approach enabled a bioresponsive release of IGF-I from hydrogels as well as spatial control over the protein distribution in 3D printed constructs which makes the system a candidate for the use in personalized medicine.
Chapter 3 gives a general overview over the necessity of wound sealants and the current generations of fibrin sealants on the market including advantages and challenges. Furthermore, it highlights trends and potential new strategies to tackle current problems and broadens the toolbox for future generations of fibrin sealants.
Chapter 4 applies the concepts of recombinant protein expression and molecular engineering to a novel generation of fibrin sealants. In a proof-of-concept study, we developed a new recombinant fibrinogen (rFbg) expression protocol and a Fbg mutant that is less susceptible to plasmin degradation. Targeted lysine of plasmin cleavage sites in Fbg were exchanged with alanine or histidine in different parts of the molecule. The protein was recombinantly produced and restricted plasmin digest was analyzed using high resolution mass spectrometry. In addition to that, we developed a novel time resolved screening protocol for the detection of new potential plasmin cleavage sites for further amino acid exchanges in the fibrin sealant.
Kovalente Inhibition stellt einen effektiven Weg dar, die Verweildauer des Liganden innerhalb einer Bindetasche zu erhöhen. In dieser Arbeit wurden theoretische Methoden angewendet, um die Reaktivität und den nichtkovalenten Zustand vor der Reaktion zu modellieren. Im Rahmen einer Fallstudie zu Cathepsin K wurden nichtkovalente Modelle von kovalenten Inhibitoren generiert. Für verschiedene Komplexe aus Cathepsin K und einem kovalent gebundenem Liganden wurde der Zustand vor der Reaktion modelliert und dessen Stabilität im Rahmen einer klassischen MD-Simulation überprüft. Die Stabilität des Warheads in der Bindetasche hing hauptsächlich vom gewählten Protonierungszustand der katalytischen Aminosäuren ab. Für eine Reihe von Inhibitoren der ChlaDUB1 wurde ein Protokoll aus quantenmechanischen Rechnungen genutzt, um die Reaktivität verschiedener Warheads abzuschätzen. Die erhaltenen Aktivierungsenergien korrelierten mit experimentell bestimmten Raten zur Inaktivierung des Enzyms. Im Rahmen eines Wirkstoffdesign-Projektes zur Deubiquitinase USP28 wurden von unpublizierten Kristallstrukturen ausgehend erste Docking-Experimente durchgeführt. Es konnte gezeigt werden, dass ein literaturbekannter Inhibitor von USP28 mit einem Warhead so modifiziert werden kann, dass die reaktive Einheit in direkter Nachbarschaft zu einem Cystein positioniert wird. Für diese Warheads wurden ebenfalls quantenmechanische Rechnungen zur Bestimmung der Aktivierungsenergie durchgeführt. Um besser nachvollziehen zu können, warum bei einem Photoswitch-Inhibitor der Butyrylcholin-Esterase der cis-Zustand des Moleküls besser inhibiert als der trans-Zustand, wurde eine Docking-Studie des Zustandes vor der Reaktion durchgeführt. Es konnte ein qualitatives Modell aufgestellt werden, das zeigt, dass der trans-Zustand aufgrund seiner längeren Form mit wichtigen Aminosäuren am Eingang der Bindungstasche kollidiert.
Background
Deregulated expression of MYC is a driver of colorectal carcinogenesis, suggesting that decreasing MYC expression may have significant therapeutic value. CIP2A is an oncogenic factor that regulates MYC expression. CIP2A is overexpressed in colorectal cancer (CRC), and its expression levels are an independent marker for long-term outcome of CRC. Previous studies suggested that CIP2A controls MYC protein expression on a post-transcriptional level.
Methods
To determine the mechanism by which CIP2A regulates MYC in CRC, we dissected MYC translation and stability dependent on CIP2A in CRC cell lines.
Results
Knockdown of CIP2A reduced MYC protein levels without influencing MYC stability in CRC cell lines. Interfering with proteasomal degradation of MYC by usage of FBXW7-deficient cells or treatment with the proteasome inhibitor MG132 did not rescue the effect of CIP2A depletion on MYC protein levels. Whereas CIP2A knockdown had marginal influence on global protein synthesis, we could demonstrate that, by using different reporter constructs and cells expressing MYC mRNA with or without flanking UTR, CIP2A regulates MYC translation. This interaction is mainly conducted by the MYC 5′UTR.
Conclusions
Thus, instead of targeting MYC protein stability as reported for other tissue types before, CIP2A specifically regulates MYC mRNA translation in CRC but has only slight effects on global mRNA translation. In conclusion, we propose as novel mechanism that CIP2A regulates MYC on a translational level rather than affecting MYC protein stability in CRC.
The WHO-designated neglected-disease pathogen Chlamydia trachomatis (CT) is a gram-negative bacterium responsible for the most frequently diagnosed sexually transmitted infection worldwide. CT infections can lead to infertility, blindness and reactive arthritis, among others. CT acts as an infectious agent by its ability to evade the immune response of its host, which includes the impairment of the NF-κB mediated inflammatory response and the Mcl1 pro-apoptotic pathway through its deubiquitylating, deneddylating and transacetylating enzyme ChlaDUB1 (Cdu1). Expression of Cdu1 is also connected to host cell Golgi apparatus fragmentation, a key process in CT infections.
Cdu1 may this be an attractive drug target for the treatment of CT infections. However, a lead molecule for the development of novel potent inhibitors has been unknown so far. Sequence alignments and phylogenetic searches allocate Cdu1 in the CE clan of cysteine proteases. The adenovirus protease (adenain) also belongs to this clan and shares a high degree of structural similarity with Cdu1. Taking advantage of topological similarities between the active sites of Cdu1 and adenain, a target-hopping approach on a focused set of adenain inhibitors, developed at Novartis, has been pursued. The thereby identified cyano-pyrimidines represent the first active-site directed covalent reversible inhibitors for Cdu1. High-resolution crystal structures of Cdu1 in complex with the covalently bound cyano-pyrimidines as well as with its substrate ubiquitin have been elucidated. The structural data of this thesis, combined with enzymatic assays and covalent docking studies, provide valuable insights into Cdu1s activity, substrate recognition, active site pocket flexibility and potential hotspots for ligand interaction. Structure-informed drug design permitted the optimization of this cyano-pyrimidine based scaffold towards HJR108, the first molecule of its kind specifically designed to disrupt the function of Cdu1. The structures of potentially more potent and selective Cdu1 inhibitors are herein proposed.
This thesis provides important insights towards our understanding of the structural basis of ubiquitin recognition by Cdu1, and the basis to design highly specific Cdu1 covalent inhibitors.
Natural light harvesting as well as optoelectronic and photovoltaic devices depend on efficient transport of energy following photoexcitation. Using common spectroscopic methods, however, it is challenging to discriminate one-exciton dynamics from multi-exciton interactions that arise when more than one excitation is present in the system. Here we introduce a coherent two-dimensional spectroscopic method that provides a signal only in case that the presence of one exciton influences the behavior of another one. Exemplarily, we monitor exciton diffusion by annihilation in a perylene bisimide-based J-aggregate. We determine quantitatively the exciton diffusion constant from exciton–exciton-interaction 2D spectra and reconstruct the annihilation-free dynamics for large pump powers. The latter enables for ultrafast spectroscopy at much higher intensities than conventionally possible and thus improves signal-to-noise ratios for multichromophore systems; the former recovers spatio–temporal dynamics for a broad range of phenomena in which exciton interactions are present.
We calculate differential Shannon entropies derived from time-dependent coordinate-space and momentum-space probability densities. This is performed for a prototype system of a coupled electron–nuclear motion. Two situations are considered, where one is a Born–Oppenheimer adiabatic dynamics, and the other is a diabatic motion involving strong non-adiabatic transitions. The information about coordinate- and momentum-space dynamics derived from the total and single-particle entropies is discussed and interpreted with the help of analytical models. From the entropies, we derive mutual information, which is a measure for the electron–nuclear correlation. In the adiabatic case, it is found that such correlations are manifested differently in coordinate- and momentum space. For the diabatic dynamics, we show that it is possible to decompose the entropies into state-specific contributions.