616 Krankheiten
Refine
Is part of the Bibliography
- yes (389)
Year of publication
Document Type
- Doctoral Thesis (215)
- Journal article (173)
- Preprint (1)
Keywords
- Biomarker (8)
- Fabry disease (8)
- HIV (8)
- Depression (7)
- Multiples Myelom (7)
- Fabry-Krankheit (6)
- Schmerz (6)
- breast cancer (6)
- schizophrenia (6)
- Aspergillus fumigatus (5)
- Aufmerksamkeitsdefizit-Syndrom (5)
- Morbus Fabry (5)
- Nebenniere (5)
- Pulmonale Hypertonie (5)
- Schlaganfall (5)
- Tissue Engineering (5)
- quality of life (5)
- stroke (5)
- ADHS (4)
- Angststörung (4)
- Autoantikörper (4)
- Dendritische Zelle (4)
- Fabry (4)
- HIV-Infektion (4)
- Herzinsuffizienz (4)
- Kernspintomografie (4)
- Parkinson-Krankheit (4)
- Parkinson’s disease (4)
- Polyneuropathie (4)
- Prognose (4)
- dopamine (4)
- enzyme replacement therapy (4)
- follow-up (4)
- heart failure (4)
- oxidative stress (4)
- prognosis (4)
- CXCR4 (3)
- Depressivität (3)
- Evoziertes Potenzial (3)
- Genetik (3)
- Genmutation (3)
- Hyperaldosteronismus (3)
- Hypertonie (3)
- Hypophosphatasie (3)
- Hypoxie (3)
- Immunaktivierung (3)
- Inflammation (3)
- Krebs (3)
- Krebs <Medizin> (3)
- Lebensqualität (3)
- MRI (3)
- Mice (3)
- Multiple Sklerose (3)
- Neisseria meningitidis (3)
- Nephroblastom (3)
- Neuropathischer Schmerz (3)
- Niereninsuffizienz (3)
- PET/CT (3)
- Pain (3)
- Plasmozytom (3)
- Regulatorischer T-Lymphozyt (3)
- Schizophrenie (3)
- Sepsis (3)
- Spinale Muskelatrophie (3)
- T-Lymphozyt (3)
- Zellkultur (3)
- antibodies (3)
- anxiety (3)
- brain (3)
- children (3)
- chronic kidney disease (3)
- depression (3)
- disease (3)
- expression (3)
- fMRI (3)
- gene (3)
- genetics (3)
- hypertrophic cardiomyopathy (3)
- magnetic resonance imaging (3)
- mice (3)
- mortality (3)
- mouse model (3)
- survival (3)
- therapy (3)
- treatment (3)
- ADHD (2)
- AIDS (2)
- ALS (2)
- Adrenocortical Carcinoma (2)
- Akutes Nierenversagen (2)
- Aldosteron (2)
- Alzheimer’s disease (2)
- Angsterkrankungen (2)
- Aspergillose (2)
- Astrozytom (2)
- B cells (2)
- Bakterielle Infektion (2)
- Bipolare Störung (2)
- CRPS (2)
- CSF (2)
- DROSHA (2)
- Diabetes mellitus Typ 1 (2)
- Durchflusscytometrie (2)
- Durchflusszytometrie (2)
- Entzündung (2)
- Enzymersatztherapie (2)
- Fabry nephropathy (2)
- Fabry-associated pain (2)
- Fatigue (2)
- Genexpression (2)
- Guillain-Barré-Syndrom (2)
- HAND (2)
- Hyperhidrose (2)
- Hypoparathyreoidismus (2)
- IL-10 (2)
- Immunhistochemie (2)
- Immunologie (2)
- Immunsystem (2)
- Immuntherapie (2)
- Kinder und Jugendliche (2)
- Kinderheilkunde (2)
- Komplexes regionales Schmerzsyndrom (2)
- Lyso-Gb3 (2)
- Mammakarzinom (2)
- Mesenchymzelle (2)
- Metastase (2)
- Motoneuron (2)
- Mucorales (2)
- Multiple myeloma (2)
- Mutation (2)
- NIR-Spektroskopie (2)
- Nahinfrarot-Spektroskopie (2)
- Nebennierenkarzinom (2)
- Nebennierenrindenkarzinom (2)
- Nebennierenrindenkrebs (2)
- Neuralgie (2)
- Neurodegeneration (2)
- Neuroendokrines System (2)
- Neuroinflammation (2)
- P300 (2)
- PET (2)
- PFE (2)
- Panikstörung (2)
- Parkinson (2)
- Parkinson disease (2)
- Parkinson's disease (2)
- Pleuraempyem (2)
- Pleuraerguss (2)
- Pooling (2)
- Positronen-Emissions-Tomografie (2)
- Prognostische Bedeutung (2)
- Sekundärkrankheit (2)
- Small RNA (2)
- Steroidhormon (2)
- Strahlentherapie (2)
- T-Zellen (2)
- Therapiemonitoring (2)
- Therapy (2)
- Thrombozyt (2)
- Transthorakale Echokardiographie (2)
- Treg (2)
- Tumor (2)
- Wilms tumor (2)
- amyotrophic lateral sclerosis (2)
- back pain (2)
- basal ganglia (2)
- biomarker (2)
- biomarkers (2)
- bipolar disorder (2)
- cancer treatment (2)
- cardiovascular disease (2)
- cardiovascular events (2)
- cell cultures (2)
- cell cycle (2)
- coronary heart disease (2)
- cystic fibrosis (2)
- deep brain stimulation (2)
- diagnosis (2)
- epidemiology (2)
- family (2)
- fibrosis (2)
- fracture (2)
- gastric cancer (2)
- gene expression (2)
- genome-wide association (2)
- hearing loss (2)
- hemodialysis (2)
- hip (2)
- hospitalization (2)
- human immunodeficiency virus (2)
- impact (2)
- in vivo (2)
- infection (2)
- inflammation (2)
- leukemia (2)
- lung (2)
- lung cancer (2)
- magnetic resonance (2)
- major depressive disorder (2)
- mechanische Thrombektomie (2)
- melanoma (2)
- messenger RNA (2)
- metaanalysis (2)
- miRNS (2)
- microRNA (2)
- multiple myeloma (2)
- multiple sclerosis (2)
- mutation (2)
- myasthenia gravis (2)
- myocardial infarction (2)
- oncolytic viruses (2)
- osteoarthritis (2)
- osteoporosis (2)
- pain (2)
- pleural empyema (2)
- polymorphisms (2)
- population (2)
- predictors (2)
- prevalence (2)
- prostate cancer (2)
- protein (2)
- pulmonary embolism (2)
- pulmonary hypertension (2)
- randomized controlled trial (2)
- recurrence (2)
- resting tremor (2)
- risk (2)
- risk factors (2)
- sepsis (2)
- shock (2)
- surgery (2)
- susceptibility (2)
- teriparatide (2)
- trial (2)
- update (2)
- validation (2)
- validity (2)
- ventilation (2)
- walking (2)
- Ängstliche Depression (2)
- (Para-)nodale Autoantikörper (1)
- 11C-Methionin (1)
- 131-I Ablation (1)
- 131-I ablation (1)
- 18F-FDG (1)
- 19F MR (1)
- 1p13.3 (1)
- 1q21 (1)
- 1st International Workshop (1)
- 22q11 (1)
- 22q11.2- Deletionssyndrom (1)
- 2B (1)
- 3D Gewebemodelle (1)
- 3D Modell (1)
- 3D cell culture (1)
- 3D model (1)
- 3D structure (1)
- 3D tissue model (1)
- 3D-Struktur (1)
- 5-Fluorouracil (1)
- 5IA-SPECT (1)
- 7q11.2 (1)
- A delta-Faser (1)
- A53T (1)
- ABC-Transporter (1)
- ADAMTS (1)
- ADMA (1)
- APCE (1)
- Acne inversa (1)
- Acute Myocardial Infarction (1)
- Acute kidney injury (1)
- Adaptorproteine (1)
- Agalsidase (1)
- Agalsidase beta therapy (1)
- Agarose (1)
- Agoraphobie (1)
- Akute Leukämie (1)
- Alcoholism (1)
- Aldosteronism (1)
- Aldosteronismus (1)
- Aldosteronsynthase-Inhibitor (1)
- Alkalische Phosphatase (1)
- Alkoholismus (1)
- Alpha galactosidase (1)
- Alter (1)
- Alveoläre Echinokokkose (1)
- Alzheimer (1)
- Alzheimer's disease (1)
- Alzheimerkrankheit (1)
- Amino acids (1)
- Anaplastic Thyroid Carcinoma (1)
- Anaplastisches Schilddrüsenkarzinom (1)
- Anderson-Fabry Disease (1)
- Aneuploidie (1)
- Aneurysma (1)
- Angst (1)
- Angsterkrankung (1)
- Angstsyndrom (1)
- Angstverarbeitung (1)
- Animal model (1)
- Ankyrin (1)
- Anorexia nervosa (1)
- Anti-Gehirn Autoantikörper (1)
- Anti-Neurofascin-Autoantikörper-assoziierten Neuropathie (1)
- Antibiotikatherapie (1)
- Antibiotikum (1)
- Antifungal (1)
- Antigen CD44 (1)
- Antimykotika (1)
- Antworthemmung (1)
- Anxiety disorder (1)
- Anxiety disorders (1)
- Anämie (1)
- Aortenklappenersatz (1)
- Aortenklappenstenose (1)
- Aortokoronarer Bypass (1)
- Apnoe-Hypopnoe-Index (1)
- ApoE\(^{(-/-)}\) (1)
- Apolipoprotein E (1)
- Appendizitis (1)
- Arbeitsgedächtnis (1)
- Arginin (1)
- Arrhythmie (1)
- Arrhythmogene Kardiomyopathie (1)
- Arrhythmogenic cardiomyopathy (1)
- Arterial water (1)
- Arterielle Verschlusskrankheit (1)
- Arteriosklerose (1)
- Aspergillosis (1)
- Aspergillus (1)
- Assoziationen (1)
- Assoziationsuntersuchung (1)
- Astrozytäre Tumore (1)
- Atherosklerose (1)
- Attention deficit / hyperactivity disorder (1)
- Attention-deficit/hyperactivity disorder (1)
- Attentional Avoidance (1)
- Attentional Bias (1)
- Aurora-A (1)
- Autismus (1)
- Autobiographie (1)
- Autoimmun (1)
- Autoimmundermatose (1)
- Automation (1)
- Axon (1)
- B lymphocytes (1)
- B-Lymphozyt (1)
- B-Zelle (1)
- B-cell lymphoma (1)
- B1 Mapping (1)
- BCI (1)
- BK virus (1)
- BRAF mutation (1)
- BRCA1 (1)
- Bacterial infection (1)
- Bakterielle Endokarditis (1)
- Bakterienlast (1)
- Barrett-Ösophagus (1)
- Barthel-Index (1)
- Behandlungsoption (1)
- Behandlungswechsel von Agalsidase beta zu Agalsidase alfa (1)
- Behinderung (1)
- Beidbeinsprung (1)
- Beinamputation (1)
- Belastungselektrokardiogramm (1)
- Bessle functions (1)
- Beta-glucocerebrosidase (1)
- Bewegungsstörung (1)
- Bildgebung (1)
- Biofilm (1)
- Biomarkers (1)
- Bioprinting (1)
- Blasenkrebs (1)
- Bloch Siegert (1)
- Blood-brain barrier (1)
- Blut-Hirn-Schranke (1)
- Blut-Rückenmarkschranke (1)
- Blutdruckmessung (1)
- Bluthochdruck (1)
- Borderline-Persönlichkeitsstörung (1)
- Brachytherapie (1)
- Brain (1)
- Breast cancer (1)
- Breast-tumors (1)
- Bronchialasthma (1)
- Bronchialkarzinom (1)
- Brustkrebs (1)
- Bullöses Pemphigoid (1)
- C-MYC (1)
- CBF (1)
- CD137 (1)
- CD137L (1)
- CD138 (1)
- CD4 T cells (1)
- CD4+ T Lymphocyte (1)
- CD4+ T Zelle (1)
- CD44 (1)
- CD44v6 (1)
- CD8+ T Zelle (1)
- CD84 (1)
- CMV (1)
- CNO (1)
- CNV (1)
- CRISPR/Cas-Methode (1)
- CRISPR/Cas9 (1)
- CRMO (1)
- CXCR4-Rezeptorexpression (1)
- CYP11B1 (1)
- CYP11B2 (1)
- CYP24A1 (1)
- CYP7A1 (1)
- Cadherine (1)
- Calcineurin (1)
- Calcium (1)
- Campylobacter jejuni (1)
- Cancer (1)
- Capicua transcriptional repressor (1)
- Carcinom (1)
- Cardiovascular Magnetic Resonance (1)
- Cartilage (1)
- Cartilage Tissue Engineering (1)
- Caspr (1)
- Ceramid-reiche Membrandomänen (1)
- Ceramide (1)
- Ceramide-enriched membrane domains (1)
- Cerebral Oxygen Saturation (1)
- Cerebrospinal fluid (CSF) (1)
- Chagas-Kardiomyopathie (1)
- Chagas-Krankheit (1)
- Charcot–Marie–Tooth disease (1)
- Chemokine (1)
- Chemokinrezeptor (1)
- Chemotherapie (1)
- Chemotherapy (1)
- Childhood (1)
- Cholesterinstoffwechsel (1)
- Cholesterintransporter (1)
- Cholinerges System (1)
- Chromatin (1)
- Chronisch-entzündliche Darmerkrankung (1)
- Chronische Herzinsuffizienz (1)
- Chronische Rhinosinusitis (1)
- Chronophin (1)
- Clinical manifestations (1)
- Cochlear-Implantat (1)
- Coefficient (1)
- Colistin (1)
- Colitis ulcerosa (1)
- Colonkrebs (1)
- Comorbidities (1)
- Comorbidity (1)
- Comorbidity survey replication (1)
- Compressed Sensing (1)
- Computertomografie (1)
- Contactin (1)
- Corneale confocale Mikroskopie (1)
- Coxarthrose (1)
- Cyclo-AMP (1)
- Cytomegalievirus (1)
- Cytotoxic T Lymphocyte (1)
- Cytotoxic T cell (1)
- D-4F (1)
- D313Y genotype (1)
- DAT (1)
- DGCR8 (1)
- DIRA (1)
- DNA (1)
- DNA Methylation (1)
- DNA methyltransferases (1)
- DNA-Methyltransferasen (1)
- DNAse (1)
- DNMT3A (1)
- DNMT3B (1)
- DNS-Schädigung (1)
- DRD2 (1)
- DSG2 (1)
- DSM-5 (1)
- DSM-IV (1)
- DSM-IV disorders (1)
- DSMM XIV (1)
- DVO Algorithmus (1)
- Darmparasit (1)
- Darmparasiten (1)
- Deflazacort (1)
- Demyelinating peripheral neuropathy (1)
- Dendritische Zellen (1)
- Dental Phobia (1)
- Deutschland (1)
- DiGeorge-Syndrom (1)
- Diabetes mellitus (1)
- Diagnosis (1)
- Diagnostik (1)
- Died Blood Spot (1)
- Died Plasma Spots (1)
- Differentiated thyroid carcinoma (1)
- Disease (1)
- Disease progression (1)
- Disease-modifying therapies (1)
- Dissemination (1)
- Dissoziale Persönlichkeitsstörung (1)
- Distress Thermometer (1)
- Domestic violence (1)
- Dopamin (1)
- Dopamin-Transporter (1)
- Dopamine (1)
- Dopamine transporter (1)
- Draize eye test (1)
- Drug development (1)
- Drug resistance (1)
- Drug testing (1)
- Duchenne dystrphy (1)
- Duplikation (1)
- E3 ubiquitin ligase (1)
- EAU guidelines (1)
- EBV (1)
- EDS (1)
- ELISPOT (1)
- ENV (1)
- EORTC (1)
- EORTC-BN20 (1)
- EORTC-QLQ-C15-PAL (1)
- EQ-5D (1)
- ESAS (1)
- ET (1)
- EUROASPIRE survey (1)
- Early-onset (1)
- Echokardiographie (1)
- Effekte von Contactin-1-IgG-Patientenantikörpern im Zellkulturmodell (1)
- Effektivität (1)
- Ehlers-Danlos syndrome (1)
- Eisenmangel (1)
- Elektrokardiogramm (1)
- Elite Controller (1)
- Elterliche Stressbelastung (1)
- Elterntraining (1)
- Emissions-Computertomographie (1)
- Encephalitis (1)
- Endokarditis (1)
- Endokrinopathie (1)
- Endothel (1)
- Endothelbarriere (1)
- Enteroide (1)
- Entwicklungsland (1)
- Enzephalitis (1)
- Enzyme replacement therapy (1)
- Enzyme-Linked Immunospot assay (ELISPOT) (1)
- Enzyme-linked immunosorbent assay (1)
- Enzymersatztherapie bei Morbus Fabry (1)
- Ependymom (1)
- Ependymoma (1)
- Epigenetics (1)
- Epilepsy (1)
- Epithel (1)
- Epstein-Barr-virus (1)
- Erreger (1)
- Essentieller Tremor (1)
- Essenzielle Thrombozytopenie (1)
- Evoked potential (1)
- Experimental stroke (1)
- Expositionstherapie (1)
- Exposure treatment (1)
- Expression (1)
- Extracorporeal Membrane Oxygenation (1)
- Extracorporeal life support (1)
- Extrakorporale Membranoxygenierung (1)
- Extrakorporale kardiopulmonale Reanimation (1)
- Extraktionskontrolle (1)
- Extramedullary disease (1)
- F-19 MRI (1)
- FAP alpha (1)
- FDG (1)
- FDG-PET/CT (1)
- FDG-PET/MRI (1)
- FIQ (1)
- FP-CIT SPECT (1)
- FRAX (1)
- Fabry cardiomyopathy (1)
- Fabry patient (1)
- Fettleber (1)
- Fettsäurestoffwechsel (1)
- Fibroblasten (1)
- Fibroblasts (1)
- Fibromyalgie (1)
- Fibromyalgiesyndrom (1)
- Fieber (1)
- Filter (1)
- Follow-up (1)
- Fontan’s Operation (1)
- Frabin/Fgd4 (1)
- Fraktur (1)
- Frakturwahrscheinlichkeit (1)
- Frauengesundheit (1)
- Frühdiagnostik (1)
- Functional Connectivity (1)
- Funktionelle Kernspintomografie (1)
- Funktionelle Konnektivität (1)
- Funktionelle Validierung (1)
- Funktionsverlust (1)
- Furchtgeneralisierung (1)
- G-protein inwardly rectifying potassium channel (1)
- GFAP (1)
- GFAP-Antikörper (1)
- GFAP-antibodies (1)
- GIRK 2 (1)
- GLA KO mouse model (1)
- GLA protein UCMGP (1)
- GP41 cytoplasmic tail (1)
- Gait initiation (1)
- Gallium-68 PET/CT (1)
- Gebärmutterhalskrebs (1)
- Gehirnendothelzellen (1)
- Gemcitabin (1)
- Gender studies (1)
- Gene-expression (1)
- Geschlechtergeschichte (1)
- Glaukom (1)
- Glia (1)
- Gliafaserprotein (1)
- Glioblastom (1)
- Glucocorticoids (1)
- Glucocorticosteroide (1)
- Glucocorticosteroidrezeptor (1)
- Glucosestoffwechsel (1)
- Glycin (1)
- Glycintransporter 2 (GlyT2) (1)
- Gompertz-Funktion (1)
- Großgefäßverschluss (1)
- HADS-D (1)
- HAND (HIV assoziierte neurologische Störungen) (1)
- HCMV infection (1)
- HE-3 diffusion MRI (1)
- HER2 (1)
- HFmrEF (1)
- HFrEF (1)
- HIF-1α (1)
- HIV-1 (1)
- HIV-Subtyp (1)
- HIV-associated dementia (1)
- HIV-associated neurocognitive disorder (HAND) (1)
- HIV-associated neurocognitive disorders (1)
- HIV-associated neurological disorders (1)
- HIV-assoziierte neurokognitive Störung (HAND) (1)
- HIV-assoziierte neurologische Erkrankungen (1)
- Habituationstraining (1)
- Haemodialysis (1)
- Hatha-Yoga (1)
- Hautlymphom (1)
- Hautstanzbiopsie (1)
- Hautzelle (1)
- Heart failure (1)
- Heart failure with preserved ejection fraction (1)
- Heart failure with reduced ejection fraction (1)
- Heavy Light Chain Assay (1)
- Helicobacter pylori (1)
- Hepatitis C infection (1)
- Hepatozelluläres Karzinom (1)
- Hereditäre spastische Spinalparalyse (1)
- Herpes-simplex-Virus (1)
- Herzerkrankung (1)
- Herzmuskelkrankheit (1)
- Herzvorhöfe (1)
- Hidradenitis suppurativa (1)
- Hiperhidrosis (1)
- Hippocampus (1)
- Hirninfarkt (1)
- Hirnkrankheit / Ischämie (1)
- History of Psychiatry (1)
- Hitzestress (1)
- Hochdosis-Glukokortikoidtherapie (1)
- Hodgkin-lymphoma (1)
- Homoarginine (1)
- Homograft (1)
- Hormonrefraktärer Prostatakrebs (1)
- Human genetics (1)
- Humangenetik (1)
- Humanserum (1)
- Hurst Exponent (1)
- Hyaliner Knorpel (1)
- Hyaluronsäure (1)
- Hydrogel (1)
- Hyperhidrosis (1)
- Hyperletale Feintypen (1)
- Hyperthermie (1)
- Hyponatriämie (1)
- Hypophosphatasia (1)
- Häusliche Gewalt (1)
- Hüftgelenkarthrose (1)
- ICD-coding of CKD (1)
- IFN-γ (1)
- IL-2 (1)
- IL28B (1)
- IMpACT (1)
- ITP (1)
- Illumina Human Exome Bead Chip (1)
- Images (1)
- Imaging (1)
- Immun-Checkpoint (1)
- Immunadsorption (1)
- Immunassay (1)
- Immunbiologie (1)
- Immune Checkpoint Therapy (1)
- Immune Escape (1)
- Immune System (1)
- Immune activation (1)
- Immune cells (1)
- Immunglobuline (1)
- Immuninfiltration (1)
- Immunoassay (1)
- Immunoglobulins (1)
- Immunoparasitologie (1)
- Immunoseneszenz (1)
- Immunosuppressant (1)
- Immunozyt (1)
- Immunpathogenese (1)
- Immunsuppression (1)
- Immunsuppressiva (1)
- Immunthrombozytopenie (1)
- Immunzellrekrutierung (1)
- Impulsivität (1)
- In-vivo (1)
- Inasive Meningokokkenerkrankung (1)
- Induzierte pluripotente Stammzelle (1)
- Infarct Zone (1)
- Infection models (1)
- Infektion (1)
- Infektionsbildgebung (1)
- Infektiöse Endokarditis (1)
- Inflamamtion (1)
- Inflammationsmarker (1)
- Infrarotspektroskopie (1)
- Inhibition (1)
- Inhibitorische Synapse (1)
- Insulin (1)
- Insulin Degrading Enzyme (1)
- Insulin resistance (1)
- Integrative Medizin (1)
- Interaktion (1)
- Interferon <gamma-> (1)
- Interleukin 17 (1)
- Interleukin 6 (1)
- Intraepidermale Nervenfaserdichte (1)
- Intrathekale Applikation (1)
- Invasive Aspergillose (1)
- Iron Oxide Nanoparticle (1)
- Iron-oxide (1)
- Iron-uptake (1)
- Ischemic stroke (1)
- Jugend (1)
- K-ras (1)
- KCNJ6 (1)
- KRas (1)
- Kaliumkanal (1)
- Kandidatengen (1)
- Kapazität (1)
- Kardiale Dekompensation (1)
- Kardiovaskuläre Komorbiditäten (1)
- Kardiovaskuläre Krankheit (1)
- Keimzentrum (1)
- Keratinozyten (1)
- Ki-67 (1)
- Kind (1)
- Kinder (1)
- Knochenbildung (1)
- Knochendichtemessung (1)
- Knochenmetastase (1)
- Knochenmetastasen (1)
- Kognition (1)
- Komorbidität (1)
- Komprimierte Abtastung (1)
- Konfokale Mikroskopie (1)
- Konformationsänderung (1)
- Kontrastmittel (1)
- Kopienzahlvariation (1)
- Koronarchirurgie (1)
- Koronare Herzkrankheit (1)
- Koronarnahtsynostose (1)
- Kranheitswahrnehmungen (1)
- Kraniometrie (1)
- Kraniometrische Vermessung (1)
- Kraniosynostose (1)
- Krebspatientinnen (1)
- Kutane T-Zell-Lymphome (1)
- Körperliche Belastung (1)
- L-arginine (1)
- LC-ESI/MS/MS (1)
- LIMP-2 (1)
- LPHN3 (1)
- LV mass (1)
- Langzeit-Elektrokardiogramm (1)
- Langzeitergebnisse (1)
- Ldlr-Knockout (1)
- Leberzellkrebs (1)
- Leichte kognitive Beeinträchtigung (1)
- Lesions (1)
- Letalität (1)
- Leukaemia-inhibitory factor (1)
- Leukoplakie (1)
- Lewy-like pathology (1)
- Limb girdle muscular dystrophy (LGMD) (1)
- Linksventrikuläre systolische Funktion (1)
- Lipom (1)
- Liquor (1)
- Lymphknoten (1)
- Lymphknotenmetastase (1)
- Lymphogranulomatose (1)
- Lymphozyt (1)
- Lysosomale Speicherkrankheit (1)
- Längsschnittstudie (1)
- Längsschnittuntersuchung (1)
- MAX (1)
- MCPH1 (1)
- MICA (1)
- MICB (1)
- MMN (1)
- MNS (1)
- MRD (1)
- MRI reporter (1)
- MS (1)
- MSC (1)
- MTCH2 (1)
- MYCN (1)
- Mad2A und Mad2B (1)
- Magnetic-resonance (1)
- Majeed (1)
- Malaria (1)
- Mamma carcinoma (1)
- Maschinelles Lernen (1)
- Mastdarmkrebs (1)
- Matrixprothese (1)
- Maus (1)
- Mausmodell (1)
- Medizin (1)
- Medizintechnik (1)
- Melanom (1)
- Memory-B-Zellen (1)
- Meningitis (1)
- Mensch (1)
- Mental Health (1)
- Mental asylums (1)
- Merkel cell carcinoma (1)
- Merkel-Zellkarzinom (1)
- Mesenchymal stem cell (1)
- Mesenchymale Progenitorzellen (1)
- Mesenchymale Stammzelldifferenzierung (1)
- Mesenchymale Stammzellen (1)
- Mesenchymale Stromazelle (1)
- Metaanalysis (1)
- Methylene blue (1)
- Methylierung (1)
- Methylphenidat (1)
- MicroRNAs (1)
- Mikrobiologie (1)
- Mikrodeletionssyndrom (1)
- Mikroglia (1)
- Mikrokern (1)
- Mikroneurographie (1)
- Milchzahnverlust (1)
- Minimal residual disease (1)
- Minimale Resterkrankung (1)
- Minipools (1)
- Mitose (1)
- Mitotane (1)
- Miyoshi myopathy (1)
- Moderator (1)
- Molekulargenetik (1)
- Monitoring (1)
- Monozyt (1)
- Morbus Alzheimer (1)
- Morbus Crohn (1)
- Motoneuronenerkrankung (1)
- Motor Control (1)
- Motorisches Gleichgewicht (1)
- Mucormycosis (1)
- Mucormykose (1)
- Mukoviszidose (1)
- Multiple sclerosis (1)
- Mundhöhlenkarzinom (1)
- Mundhöhlenkrebs (1)
- Mundschleimhautäquivalent (1)
- Muskelatrophie (1)
- Myatrophische Lateralsklerose (1)
- Mycobacterium caprae (1)
- Mycobacterium tuberculosis complex (1)
- Myokardprotektion (1)
- N-Myc (1)
- N-Myc down regulated gene 1 (1)
- NADPH oxidase inhibitors (1)
- NADPH oxidases (NOX) (1)
- NAFLD (1)
- NCAM1 (1)
- NIRS (1)
- NMO-IGG (1)
- NOS1AP (1)
- NPU (1)
- NR3C1 (1)
- NRG1 (1)
- NSCLC (1)
- Nachsorge (1)
- Nahinfrarotspektroskopie (1)
- Naive T-Zelle (1)
- Nationalsozialismus (1)
- Natriuretisches Hormon (1)
- Natürliche Killerzellen (1)
- Nazi Germany (1)
- Near-Infrared Spectroscopy (1)
- Nebennierenerkrankung (1)
- Nebenniereninsuffizienz (1)
- Nebennierenkrise (1)
- Nebennierenrinde (1)
- Nebennierentumor (1)
- Nebennierenvenenkatheter (1)
- Nebenwirkungen (1)
- Neogenin-1 (1)
- Neoplasma (1)
- Nephrogenese (1)
- Nervenfaser (1)
- Nervensonographie (1)
- Netrin-1 (1)
- Netzwerkrekonstruktion (1)
- Netzwerksimulation (1)
- Neuroblastom (1)
- Neurofascin (1)
- Neurofascin-155-IgG4-(Para-)nodopathie (1)
- Neurofascin-155-IgM (1)
- Neurogenese (1)
- Neurohormone (1)
- Neuroimaging (1)
- Neurological complications (1)
- Neurologische Komplikationen (1)
- Neuromuskuläre Erkrankungen (1)
- Neuromuskuläre Krankheit (1)
- Neuropathie (1)
- Neuropathy (1)
- Neuropeptid Y (1)
- Neuroprotection (1)
- Neuroradiologie (1)
- Neuroradiology (1)
- Next-Generation Sequencing (1)
- Nicht-motorische Begleitsymptome (1)
- Niederfrequenzstimulation (1)
- Nierenversagen (1)
- Normal breast (1)
- OECD guideline (1)
- ON-Freezing (1)
- OPN (1)
- Oncostatin M (1)
- OncotypeDX\(^{®}\) (1)
- Onkologie (1)
- Opc (1)
- Operative Therapie (1)
- Optische Dichte (1)
- Osmr-Knockout (1)
- Ossifikation (1)
- Osteopontin (1)
- Osteoporose (1)
- Outcome survey (1)
- Ovarian (1)
- Oxidativer Stress (1)
- Oxygen partial pressure (1)
- Oxytocin (1)
- P. falciparum (1)
- PAI-1 (1)
- PAPA (1)
- PAVK (1)
- PCR (1)
- PDH (1)
- PDXP (1)
- PET-Tracer (1)
- PET/CT imaging (1)
- PHQ (1)
- PHQ-2 (1)
- PHQ-4 (1)
- PKP2 (1)
- PRR (1)
- PSMA (1)
- PSMA-Rezeptorexpression (1)
- PTH1R (1)
- Paclitaxel (1)
- Paediatrics (1)
- Palliativmedizin (1)
- Palliativonkologie (1)
- Palliativtherapie (1)
- Pan-Neurofascin-IgG3 (1)
- Pan-Raf-Inhibition (1)
- Paniksyndrom (1)
- Paranodale und nodale Autoantikörper (1)
- Parasitologie (1)
- Parkinson Disease (1)
- Parkinson's Disease (1)
- Parkinsons disease (1)
- Parodontitis (1)
- Particles (1)
- Pathogener Mikroorganismus (1)
- Pathogenese (1)
- Pattern-Recognition-Receptors (1)
- Pds5A und Pds5B (1)
- Peak Caller (1)
- Pemphigus (1)
- Perfluorkarbon (1)
- Perfusion (1)
- Periphere arterielle Verschlusskrankheit (1)
- Pharmacological management (1)
- Phobie (1)
- Phosphatase (1)
- Physical impairment (1)
- Pilocytic astrocytoma (1)
- Pilomyxoid astrocytoma (1)
- Pilomyxoides Astrozytom (1)
- Pilozytisches Astrozytom (1)
- Pilze (1)
- Platelets (1)
- Plattenepithelkarzinom (1)
- Platy (1)
- Polymerase-Kettenreaktion (1)
- Polymorphismen (1)
- Polymorphismus (1)
- Positronen-Emissions-Tomographie (1)
- Positronenemissionstomographie (1)
- Prednisolon (1)
- Preoperative radiological diagnostics (1)
- Prevalence (1)
- Primary cell lines (1)
- Primary failure of eruption (1)
- Primär kutanes Lymphom (1)
- Primäre Zahndurchbruchstörung (1)
- ProCort (1)
- Programmed Cell Death 1 (1)
- Programmed Cell Death Ligand 1 (1)
- Progranulin (1)
- Progression zu AIDS (1)
- Prospektive klinische Verlaufsstudie (1)
- Prostatakarzinom (1)
- Prostatakrebs (1)
- Protein A-Adsorber (1)
- Protein interactor (1)
- Proteins (1)
- Proteintransport (1)
- Prädiktor (1)
- Prädiktoren (1)
- Präfrontaler Cortex (1)
- Präkonditionierung (1)
- Präoperative radiologische Diagnostik (1)
- Präsynaptische Hyperekplexie (1)
- Pseudomonas aeruginosa (1)
- Psychiatrie (1)
- Psychiatriegeschichte (1)
- Psychische Störung (1)
- Psychologische Profile (1)
- Psychoneuroimmunologie (1)
- Psychopharmaka (1)
- Pulmonalarterielle Hypertonie (1)
- Pycnogenol (1)
- Pädiatrie (1)
- QST (1)
- QTc prolongation (1)
- QTc-Zeit (1)
- QTc-Zeit Verlängerung (1)
- Quality of life (1)
- Quantitativ sensorische Testung (1)
- Quantitative Echtzeit-Polymerase-Kettenreaktion (1)
- Quantitative sensorische Testung (1)
- Quantitativer sudomotorischer Axonreflextest (1)
- Quorum-Sensing (1)
- R-Roscovitine (1)
- RA-LA-Quotient (1)
- RA/LA-Quotient (1)
- RDoC (1)
- RNA interference (1)
- RNA-Sequenzierung (1)
- RRM1 (1)
- Raf-Kinasen (1)
- Raman spectroscopy (1)
- Raman-Spektroskopie (1)
- Random Forest (1)
- Randomized controlled trial (1)
- Ranvier-Schnürring (1)
- Rats (1)
- Raucherbein (1)
- Real-time PCR (1)
- Recovery (1)
- Rekanalisation Hirninfarkt (1)
- Rektumkarzinom (1)
- Relative Telomerlänge (RTLs) (1)
- Reliabilität (1)
- Resistenz (1)
- Retrosepektiv (1)
- Rezeptor (1)
- Rezidiv (1)
- Rhinosinusitis (1)
- Rhizopus arrhizus (1)
- Rho-GTPase Cdc42 (1)
- Ribonucleasen (1)
- Risikofaktoren (1)
- Rochester diabetic neuropathy (1)
- Roscovitine (1)
- Ross-Prozedur (1)
- Ross-procedure (1)
- SAH (1)
- SCD (1)
- SCF (1)
- SDMA (1)
- SHIP-TREND (1)
- SIS/MUC (1)
- SIX1 (1)
- SKP1 (1)
- SLC2A3 (1)
- SLC6A5 (1)
- SMA (1)
- SNAP-Rezeptor (1)
- SNP (1)
- SPG17 (1)
- SVR (1)
- Sagittalnahtsynostose (1)
- Salmonella-typhimurium (1)
- Salzstress (1)
- Sarcoidosis (1)
- Sarkoidose (1)
- Sarkopenie (1)
- Saure Sphingomyelinase (1)
- Scale (1)
- Schilddrüse (1)
- Schilddrüsenkarzinom (1)
- Schilddrüsenkrebs (1)
- Schimmelpilze (1)
- Schlafapnoe (1)
- Schlafbezogene Atmungsstörung (1)
- Schlussleistenkomplex (1)
- Schmerz-assoziierte evozierte Potenziale (1)
- Schmerzerfassung (1)
- Schwertkärpfling (1)
- Schädelnaht (1)
- Score (1)
- Sekundäre Hypertonie (1)
- Sekundäre Inflammation (1)
- Sekundärneoplasie (1)
- Sekundärtumor (1)
- Selbstzeugnisse (1)
- Seltene Krankheit (1)
- Sensitivität (1)
- Sensorik <Neurophysiologie> (1)
- Septal bulge (1)
- Septumwulst (1)
- Sequenzdaten (1)
- Serotonin (1)
- Short dsRNA oligonucleotides (1)
- Signaltransduktion (1)
- Signalwege (1)
- Simulation (1)
- Small Fiber Neuropathie (1)
- Small fiber Neuropathie (1)
- Small-fiber neuropathy (1)
- Snap25 (1)
- Soft-tissue infection (1)
- Specific Phobia (1)
- Spender-Chimärismus (1)
- Spezifische Phobien (1)
- Spezifität (1)
- Sphingomyelinphosphodiesterase (1)
- Spiegelneuron (1)
- Spinal muscular atrophy (DLC) (1)
- Spontan Hypertensive Ratte (1)
- Sprachentwicklung (1)
- Sprunganalyse (1)
- Sprungleistung (1)
- Stammzellen (1)
- Stammzelltransplantation (1)
- Staphylococcus aureus (1)
- Stem cells plasticity (1)
- Stent Retriever Schlaganfall (1)
- Sterblichkeit (1)
- Steroide (1)
- Stickstoffmonoxid (1)
- Stiff-Person-Syndrom (1)
- Stimmband (1)
- Stimmlippe (1)
- Strahlenbelastung (1)
- Strahlentherapie bei Morbus Hodgkin (1)
- Stress-Kardiomyopathie (1)
- Stressreaktion (1)
- Strongyloides (1)
- Strongyloides stercoralis (1)
- Störung (1)
- Störung des Sozialverhaltens (1)
- Subarachnoidalblutung (1)
- Sudden cardiac death (1)
- Sugar-transport (1)
- Superparamagnetic Iron Oxide (1)
- Surrogate endpoints (1)
- Symptommanagement (1)
- Systembiologie (1)
- Säugling (1)
- Südliches Afrika (1)
- T Helfer Zelle (1)
- T Helper Cell (1)
- T Lymphocyte (1)
- T cells (1)
- T-DM1 (1)
- T-PA (1)
- T-Zell-Lymphom (1)
- T-Zell-Rezeptor-Excision-Circle (TRECs) (1)
- T-Zelle (1)
- T-cell reactivity (1)
- TASK (1)
- TAVI (1)
- TEER-Wert (1)
- TEVC (1)
- TIC disorders (1)
- TKI (1)
- TLR4 (1)
- TNAP (1)
- TNF-α (1)
- TRESK (1)
- TTFields (1)
- Tandem-Massenspektrometrie (1)
- Tandem-Peptid (1)
- Tansania (1)
- Tanzania (1)
- Targeted Metabolomics (1)
- Targeted therapies (1)
- Taxol (1)
- Th17 Zelle (1)
- Th17 cell (1)
- Therapie (1)
- Therapiesimulation (1)
- Thrombo-inflammation (1)
- Thrombolysis stroke (1)
- Thrombozytenfunktionsanalyse (1)
- Thyroid cancer (1)
- Tiermodell (1)
- Tight junction (1)
- Tissue engineering (1)
- Tobramycin (1)
- Trabekulektomie (1)
- Tracer (1)
- Tracking (1)
- Trailmaking Test (1)
- Transkriptionsfaktor (1)
- Transposon (1)
- Treatment (1)
- Treatment switch in fabry disease (1)
- Triamcinolon (1)
- Trinkerfürsorge (1)
- Trypanosoma (1)
- Tuberkulose (1)
- Tumor Immunology (1)
- Tumor models (1)
- Tumordiagnostik (1)
- Tumormodell (1)
- Tumorstammzellen (1)
- Tumortherapiefelder (1)
- Tumorvolumen (1)
- UME6 (1)
- UNC5B (1)
- Ultra-Short Screening (1)
- Ultraschalldiagnostik (1)
- United States (1)
- Universitätspsychiatrie (1)
- V. saphena magna (1)
- VAL66MET polymorphism (1)
- VE-Cadherin (1)
- VYOO VYOO-PCR (1)
- Vagus (1)
- Vagus-somatosensorisch evozierte Potentiale (1)
- Valproat (1)
- Vascular system (1)
- Vaskulitische Polyneuropathie (1)
- Vasopressin (1)
- Vasoreagibilität (1)
- Verhalten (1)
- Verhaltensauffälligkeiten (1)
- Verhaltensstörung (1)
- Verkalkung (1)
- Vincristin (1)
- Virologie (1)
- Virulenzfaktor (1)
- Vitamin D (1)
- Vitamin D-Rezeptor (1)
- Vitamin D3 (1)
- Vitamin K-abhängige Gerinnungsfaktoren II, VII, IX, X (1)
- Volon A (1)
- Von-Willebrand-factor (1)
- Vorhersage (1)
- WB-DW-MRI (1)
- Wachstumsrate (1)
- Wilms Tumor (1)
- Wilms-Tumor (1)
- Wirkstofftestung (1)
- Women´s studies (1)
- Working memory (1)
- X-Chromosom (1)
- X-Inaktivierung (1)
- Xiphophorus (1)
- Yoga (1)
- Zahnbehandlungsphobie (1)
- Zahndurchbruch (1)
- Zelldifferenzierung (1)
- Zellzyklus (1)
- Zerebrale Gewebeoxygenierung (1)
- Zerebraler Insulinmetabolismus (1)
- Zwergfadenwurm (1)
- Zytotoxische T Zelle (1)
- ablation (1)
- accuracy (1)
- acetylsalicylic acid exacerbated respiratory disease (1)
- acid sphingomyelinase (1)
- acoustic startle (1)
- acquired immunodeficiency-syndrome (1)
- activation (1)
- acute (1)
- acute ischemic stroke (1)
- acute kidney injury (1)
- acute liver failure (1)
- acute management of stroke (1)
- acute neurology (1)
- acute stroke imaging (1)
- acute stroke management (1)
- acute stroke outcome (1)
- adalimumab (1)
- adjuvant (1)
- adrenal cortex hormones (1)
- adrenal cortex neoplasms (1)
- adrenal imaging (1)
- adrenal tumours (1)
- adult (1)
- adulte Neurogenese (1)
- adulthood (1)
- aerobic glycolysis (1)
- agalsidase-beta (1)
- age (1)
- agr (1)
- akutes Koronarsyndrom (1)
- aldosterone (1)
- aldostoreone synthase inhibitor (1)
- alendronate (1)
- alkaline phosphatase (1)
- allergic rhinitis (1)
- allogene Stammzelltransplantation (1)
- allografts (1)
- alpha galactosidase (1)
- alpha-galactosidase A (1)
- alpha-galactosidase-A (1)
- alpha-synuclein (1)
- alternatives (1)
- alveolar (1)
- animal model (1)
- animal models (1)
- anti-Amphiphysin Antikörper (1)
- anti-GFAP (1)
- anti-amphiphysin antibodies (1)
- anti-aquaporin-4 antibody (1)
- anti-brain autoantibodies (1)
- antigen (1)
- antioxidant function (1)
- antipsychotics (1)
- antirheumatic agents (1)
- anxiety disorders (1)
- aortic valve (1)
- aortic valve disease (1)
- apnoea-hypopnoea-index (1)
- apomorphine (1)
- apoptosis (1)
- aquaporin-4 autoantibodies (1)
- argeted therapy (1)
- arm (1)
- arrhythmia (1)
- arterielle Blutgasanalyse (1)
- arterielle Hypertonie (1)
- artery occlusion (1)
- arthritis (1)
- arthroplasty (1)
- articular cartilage progenitor cells (1)
- aspirin sensitivity (1)
- aspirin-induced asthma (1)
- association (1)
- asthma (1)
- asthma bronchiale (1)
- astrocytic tumor (1)
- atypical (1)
- auditory (1)
- autism (1)
- autobiographical notes (1)
- autoimmune (1)
- autoimmunity (1)
- autonomous cortisol secretion (1)
- awareness (1)
- axonopathic changes (1)
- axons (1)
- b-cell (1)
- b-lymphocyte (1)
- behaviour problems (1)
- beta oscillations (1)
- beta-TRCP (1)
- binding (1)
- binge eating (1)
- bioinformatic (1)
- bioinformatics (1)
- biopsy findings (1)
- biosynthesis (1)
- bipolar (1)
- bipolare (1)
- bladder cancer (1)
- blasenbildende Autoimmunerkrankung (1)
- blood biomarker (1)
- blood brain barrier (1)
- blood-brain barrier (1)
- blood-glucose control (1)
- bone (1)
- bone colonization (1)
- bone formation (1)
- bone marrow transplantation (1)
- bone metastases (1)
- bone-mineral density (1)
- brain cancer (1)
- brain computer interface (1)
- brain edema (1)
- brain tumours (1)
- cALL (1)
- calcium (1)
- calcium cycling (1)
- cancer (1)
- cancer patients (1)
- cancer stem cells (1)
- capillary leak (1)
- carcinomas (1)
- cardiac energy metabolism (1)
- cardiac hypertrophy (1)
- cardiac magnetic resonance imaging (1)
- cardiogenic (1)
- cardiopulmonary exercise testing (1)
- cardiovascular care (1)
- cardiovascular magnetic-resonance (1)
- cardiovascular morbidity (1)
- cardiovascular risk factors (1)
- cartilage (1)
- cell culture (1)
- cell-cycle arrest (1)
- cells (1)
- cellular proteins (1)
- central nervous system (1)
- cerebrospina (1)
- cerebrospinal fluid culture (1)
- cerebrospinal-fluid (1)
- chemical properties (1)
- chemotherapy (1)
- childhood cancer (1)
- children and adolescents (1)
- chip analyses (1)
- chondrogene Differenzierung (1)
- chronic distress (1)
- chronic heart failure (1)
- chronic immune activation (1)
- chronic kidney-disease (1)
- chronic thromboembolic pulmonary hypertension (1)
- chronic viral infection (1)
- chronisch-entzündliche Darmerkrankung (1)
- chronische Hyponatriämie (1)
- chronische Multiple Sklerose (1)
- chronophin (1)
- circuitopathies (1)
- circulating (1)
- circulating tumor cells (1)
- classification (1)
- clinical (1)
- clinical diagnosis (1)
- clinical study (1)
- clinical trials (1)
- clinical-practice (1)
- coefficient (1)
- cognitive decline (1)
- colistin (1)
- collarless (1)
- colony-stimulating factor (1)
- colorectal cancer (1)
- common SNPS (1)
- complex diseases (1)
- complex disorders (1)
- complex regional pain syndrom (1)
- complication (1)
- comprehensive management (1)
- comprehensive psychosomatic assessment (1)
- computed tomography (1)
- consortium (1)
- contrast-enhanced MRI (1)
- controlled clinical-trials (1)
- coordination (1)
- copy number variants (1)
- cornea verticillata (1)
- corneal equivalent (1)
- coronar suture (1)
- coronary artery bypass grafting surgery (1)
- coronary artery disease (1)
- coronary calcification (1)
- coronary-artery calcification (1)
- coverage (1)
- craniometric (1)
- craniosynostosis (1)
- crantiectomy (1)
- craving (1)
- creatine synthesis (1)
- critically ill (1)
- cryptogenic stroke (1)
- ctrA Gen (1)
- cue (1)
- cutaneous T-cell lymphomas (1)
- cytokine (1)
- cytokine secretion kinetics (1)
- cytokine stimulation (1)
- cytomegalovirus (1)
- damage responses (1)
- darbepoetin alpha (1)
- database (1)
- deciduous tooth loss (1)
- decompressive surgery (1)
- degeneration (1)
- dehydrogenases (1)
- dendritic cells (1)
- dendritische Zellen (1)
- dental stem cells (1)
- dentale Stammzellen (1)
- dentate gyrus (1)
- dependency (1)
- design (1)
- desmosomal mutations (1)
- developing country (1)
- dexamethasone suppression test (1)
- diabetes complications (1)
- diabetes mellitus (1)
- diabetes mellitus type 2 (1)
- diabetic mouse (1)
- diabetic nephropathy (1)
- diagnostic (1)
- dialysis (1)
- differentially expressed genes (1)
- differentiation (1)
- diffusion weighted MRI (1)
- diffusion-weighted MRI (1)
- disability (1)
- disease progression (1)
- disease-modifying therapies (1)
- disorder (1)
- dolutegravir (1)
- dopamine acetylcholine (1)
- double-blind (1)
- drug development (1)
- duchenne muscular dystrophy (1)
- duodenal levodopa infusion (1)
- dysferlinopathy (1)
- dyspnea (1)
- early diagnosis (1)
- ejection fraction (1)
- electrocardiogram (1)
- electroporation (1)
- elispot (1)
- elucidation (1)
- embolic stroke (1)
- emotional regulation (1)
- emtricitabine (1)
- encephalitis dementia (1)
- end stage renal disease (1)
- endocarditis (1)
- endocrinology (1)
- endogenous psychoses (1)
- endophenotype (1)
- endothelial barrier (1)
- endotheliopathy (1)
- endotoxemia (1)
- endovascular recanalization stroke (1)
- endovaskuläre Therapie Hirninfarkt (1)
- enteroid (1)
- entorhinal cortex (1)
- environment (1)
- enzyme-linked immunoassays (1)
- epigastric hernia (1)
- epimutation (1)
- eukaryota (1)
- euroaspire (1)
- exacebrated respiratory-disease (1)
- exercise (1)
- exhaustion (1)
- experimental (1)
- experimental autoimmune encephalomyelitis (1)
- expression pattern (1)
- extensiv transverse myelitis (1)
- extracellular matrix (1)
- extracellular matrix remodeling (1)
- extracorporeal membrane oxygenation (1)
- eye irritation testing (1)
- fMRT (1)
- fabry disease (1)
- factor expression (1)
- fatty liver disease (1)
- fear of progression (1)
- feasibility (1)
- female cancer patients (1)
- femoral revision (1)
- fetuin A (1)
- fibromyalgia (1)
- fibrosis progression (1)
- field (1)
- filtering (1)
- flow cytometry (1)
- fluid (1)
- fluorescent-probes (1)
- focal cerebral ischemia (1)
- focal semental glomerulosclerosis (1)
- folinic acid (1)
- follicular lymphoma reactive germinal centers (1)
- follikuläre Lymphome erhaltene reaktive Keimzentren (1)
- follikulärer (1)
- food addiction (1)
- fosfomycin (1)
- foxes vulpes-vulpes (1)
- fracture risk (1)
- freezing of gait (1)
- frontal cortex (1)
- functional imaging (1)
- functional neuroanatomy (1)
- functional resting-state connectivity (1)
- funktionelle Magnetresonanztomographie (1)
- funktionelle Resting-State Konnektivität (1)
- gadofluorine (1)
- gadolinium-DTPA (1)
- gait (1)
- gait analysis (1)
- gambling (1)
- gastroesophageal reflux (1)
- gastroesophageal reflux disease (1)
- gastrointestinal tumors (1)
- gastrointestinale Tumore (1)
- gemcitabine (1)
- gene ontology (1)
- gene-environment interaction (1)
- genetic heterogeneity (1)
- genetic interaction (1)
- genetic modifiers (1)
- genetic renal disease (1)
- genetic risk factor (1)
- genetic variation (1)
- genome-wide association study (GWAS) (1)
- genomic damage (1)
- germany (1)
- germinal center (1)
- giant ventral hernia (1)
- gilles (1)
- glioblastoma (1)
- glioblastoma cell-lines (1)
- glioblastoma multiforme (1)
- glomerular-filtration-rate (1)
- glucose transporter (1)
- glycine uptake (1)
- glycoprotein incorporation (1)
- granzyme B (1)
- green fluorescent protein (1)
- gridle muscular-dystrophy (1)
- group-B (1)
- growth (1)
- growth factor (1)
- guideline adherence (1)
- guideline implementation (1)
- guidelines (1)
- hENT1 (1)
- haplogroups (1)
- hcv infection (1)
- health care research (1)
- health questionnaire (1)
- health-related quality of life (1)
- heat shock protein Hsc-70 (1)
- helminths (1)
- hematopoietic (1)
- hematopoietic stem cells (1)
- hemicraniectomy (1)
- heptacellular carcinoma (1)
- hereditary motor and sensory neuropathy (1)
- hereditary spastic paraplegia (1)
- heritability (1)
- herpes virus (1)
- highly active antiretroviral treatment (1)
- hospital medical complications (1)
- host genetics (1)
- human (1)
- human brain microvascular endothelial cells (1)
- human cancer diseases (1)
- human cytomegalovirus (HCMV) (1)
- human diseases (1)
- human induced pluripotent stem cells (hiPSC) (1)
- humanized bone models (1)
- hyperhidrosis (1)
- hyperpolarized HE-3 (1)
- hypertension (1)
- hyponatremia (1)
- iPSC (1)
- imaging mass spectrometry (1)
- immune neuromelanin (1)
- immune pathogenesis (1)
- immune response (1)
- immune suppression (1)
- immune thrombocytopenia (1)
- immune-response (1)
- immunity (1)
- immunoglobulin-G (1)
- immunohistochemistry (1)
- immunology (1)
- immunology and microbiology section (1)
- immunosenescence (1)
- impaction bone grafting (1)
- impulse control disorders (1)
- impulsivity (1)
- in situ guided tissue regeneration (1)
- in vitro (1)
- incisional hernia (1)
- induced insulin-release (1)
- infant skull (1)
- infants (1)
- infectious endocarditis (1)
- infectious-disease diagnostics (1)
- infiltrate (1)
- inflammatory bowel disease (1)
- inflammatory diseases (1)
- inguinal lymph node dissection (1)
- inherited metabolic disorders (1)
- inhibitor (1)
- initial experience (1)
- insulin (1)
- insulin receptor (1)
- insulin-like growth factor 1 receptor (1)
- integrase inhibitor (1)
- intensivierte postoperative Nachsorge (1)
- interval timing (1)
- intestinal epithelial barrier (1)
- intestinal parasites (1)
- intestinale Epithelbarriere (1)
- intractable hiccup (1)
- intrathecal (1)
- intrathekal (1)
- invasive cysticerocsis (1)
- involvement (1)
- irinotecan (1)
- iron oxide nanoparticles (1)
- ischaemic stroke (1)
- ischemic stroke (1)
- ischämischer Schlaganfall (1)
- joint-action (1)
- journals (1)
- juvenile idiopathic arthritis (1)
- kardiale Hypertrophie (1)
- kidney (1)
- kidney development (1)
- kidney neoplasms (1)
- kidney-disease CKD (1)
- kidneys (1)
- kinases (1)
- kindliche Leukämie (1)
- kindliche Traumatisierung (1)
- kinematics (1)
- kinetics (1)
- knees (1)
- konservative Tumortherapie (1)
- laparostomy (1)
- late gadolinium enhancement (1)
- latency (1)
- left lateral wall (1)
- left ventricular mass (1)
- left-ventricular hypertrophy (1)
- leukoplakia (1)
- life expectancy (1)
- lipid desaturation (1)
- lipidomics (1)
- lipoxygenase (1)
- liver resection (1)
- locally advanced disease (1)
- loci (1)
- locus coeruleus (1)
- longitudinal study (1)
- loss of function (1)
- lovastatin (1)
- lung and intrathoracic tumors (1)
- lymph nodes (1)
- lymphoma (1)
- lysosomal storage disease (1)
- mTOR-inhibitor RAD-001 (1)
- magnetic resonance spectroscopy (1)
- magnetic resonsance imaging (1)
- magnetic-resonance behavior (1)
- magnetic-resonance-spectroscopy (1)
- malaria (1)
- malignant MCA infarct (1)
- malignant lymphoma (1)
- malignant melanoma (1)
- management (1)
- maritime pine bark extract (1)
- mass spectrometry (1)
- matrix metalloproteinase (1)
- measles (1)
- mechanical energy (1)
- mechanical thrombectomy stroke (1)
- mechanisms (1)
- memory (1)
- memory b cell (1)
- memory cells (1)
- memory deficits (1)
- meningococcal disease (1)
- meningococcal polysaccharides (1)
- mesenchymal progenitor cells (1)
- mesenchymal stem cell differentiation (1)
- mesenchymal stem cells (1)
- mesenchymal tissues (1)
- metabolism (1)
- metabolomics (1)
- metastasis (1)
- methylation (1)
- miRNA (1)
- micro processor complex (1)
- microRNAs (1)
- microRNA–target interaction (1)
- microangiopathy (1)
- microarray (1)
- microarrays (1)
- microcephalin 1 (1)
- microdeletion (1)
- microprocessor complex (1)
- migraineur (1)
- mineral metabolism (1)
- mineralocorticoid antagonist (1)
- minimal (1)
- missing heritability (1)
- mitochondria (1)
- modifizierter Dexamethason-Suppressions-Test (1)
- modular (1)
- modulation (1)
- molecular genetics (1)
- molecular mechanism (1)
- molecular medicine (1)
- monozygotic twins (1)
- mood disorder (1)
- morbidity (1)
- morphogenesis (1)
- morphometry (1)
- motor function (1)
- mouse models (1)
- movements (1)
- mucormycosis (1)
- multicenter (1)
- multicenter study (1)
- multigene-array (1)
- multimodal (1)
- multiple diseases (1)
- multiple system atrophy (1)
- multiple-sclerosis (1)
- multizentrische Studie (1)
- murine gammaherpesvirus 68 (1)
- muscle strength (1)
- mutant p53 (1)
- myelin (1)
- myelination (1)
- myeloid (1)
- myocardial lipid content (1)
- nab-paclitaxel (1)
- national health survey (1)
- natural-history data (1)
- near infrared spectroscopy (1)
- neoadjuvant (1)
- neoadjuvant chemotherapy (1)
- neonatales Pemphigus-Maus-Modell (1)
- neoplasm (1)
- nerve fibers (1)
- nerve ultrasonography (1)
- nervous system (1)
- network reconstruction (1)
- network simulation (1)
- neural apoptosis (1)
- neural stem cells (1)
- neuregulin-1 (1)
- neuroinflammation (1)
- neuromelanin (1)
- neuromuskuläres Assesment (1)
- neuron navigator 3 (1)
- neuroprotection (1)
- neuropsychiatric disorders (1)
- neurotrophic factor (1)
- neurotrophic factor gene (1)
- nicotinic receptors (1)
- nictric-oxide (1)
- noradrenalin (1)
- norepinephrine (1)
- nuclear antigen (1)
- nuclear magnetic resonance (1)
- nucleus (1)
- nucleus accumbens (1)
- number (1)
- obesity (1)
- observational study (1)
- oligonucleotides (1)
- opc (1)
- open abdomen (1)
- optical coherence tomography (1)
- oral anticancer drugs (1)
- orales Plattenepithelkarzinom (1)
- orales Plattenepithelkarzinomäquivalent (1)
- osteogene Differenzierung (1)
- osteogenic differentiation (1)
- outcomes (1)
- overdose (1)
- oxaliplatin (1)
- oxidativer Stress (1)
- p53-dependent apoptosis (1)
- p53-inducible regulator (1)
- paclitaxel (1)
- paediatric patients (1)
- pain questionnaire (1)
- pancreatic cancer (1)
- parental stress (1)
- parkinson disease (1)
- particles (1)
- partitioning analysis RPA (1)
- pathogen (1)
- patient (1)
- patients’ awareness (1)
- pdxp (1)
- pediatric (1)
- pediatrics (1)
- peptide vaccination (1)
- peri- und postoperative Komplikationen (1)
- perioperative and postoperative complications (1)
- peripheral neuropathy (1)
- persistence (1)
- persistent ADHD (1)
- perspectives (1)
- pet (1)
- pharmacology (1)
- pharmacotherapy (1)
- phase contrast (1)
- phenotype (1)
- phosphatase (1)
- phosphodiesterase (1)
- physicians’ awareness (1)
- pine bark extract (1)
- plasma membrane (1)
- plasmid construction (1)
- plasmodium falciparum (1)
- platelet dysfunction (1)
- pleural effusion (1)
- podocyte (1)
- point-of-care echocardiography (1)
- polymorphism (1)
- polyomavirus (1)
- polyphenols (1)
- porous-coated stems (1)
- postkapilläre pulmonale Hypertonie (1)
- postoperativ (1)
- preconditioning (1)
- predictive biomarker (1)
- predictor (1)
- prednisone (1)
- preserved ejection fraction (1)
- presynaptic hyperekplexia (1)
- prevalent fractures (1)
- primary aldosteronism (1)
- primary cutaneous lymphoma (1)
- primary focal hyperhidrosis (1)
- primäre fokale Hyperhidrose (1)
- primärer Hyperaldosteronismus (1)
- prognostic (1)
- prognostic biomarker (1)
- prognostic index (1)
- prognostischer Marker (1)
- progression (1)
- progression to AIDS (1)
- progressive multiple sclerosis (1)
- proliferation (1)
- prostatic neoplasms (1)
- prosthesis (1)
- proteasome (1)
- protein-protein interaction network (1)
- proteinuria (1)
- proteolipid protein gene (1)
- proton (1)
- prädiktiver Marker (1)
- psma (1)
- psychiatric disorders (1)
- psychoneuroimmunology (1)
- psychopathology (1)
- pulmonary arterial hypertension (1)
- pulmonary artery (1)
- pulmonary artery pressure (1)
- pulmonary circulation (1)
- pulse wave velocity (1)
- pulses (1)
- qPCR (1)
- quality indicators (1)
- quality of health care (1)
- quality-of-care (1)
- radiation oncology (1)
- radical cystectomy (1)
- radiotherapy (1)
- randomized controlled study (1)
- rankin scale (1)
- rare diseases (1)
- rat (1)
- rat kidney (1)
- recurrent Tako-Tsubo cardiomyopathy (1)
- refeeding syndrome (1)
- reflex (1)
- regenerative medicine (1)
- regional recurrence (1)
- registries (1)
- registry (1)
- regression analysis (1)
- regulator (1)
- regulatory T cell (1)
- reliability (1)
- renal cancer (1)
- renal fibrosis (1)
- renal function (1)
- renal osteodystrophy (1)
- renale Kalzifikationen (1)
- replacement (1)
- replacement therapy (1)
- residual (1)
- resistance (1)
- resource limited setting (1)
- respiratory virus (1)
- response evaluation (1)
- responsiveness (1)
- ressourcenarme Länder (1)
- restoration (1)
- resveratrol (1)
- retinal ganglion cells (1)
- retinocochleocerebral (1)
- retrospective study (1)
- revision (1)
- rheumatoid (1)
- right inferior frontalgyrus (1)
- risk factor (1)
- risk-factors (1)
- roentgenographic assessment (1)
- rolipram (1)
- sVE-Cadherin (1)
- sae (1)
- salvage radiotherapy (1)
- sar (1)
- scaffolds (1)
- scale (1)
- schlafbezogenen (1)
- sclerostin (1)
- screening for distress (1)
- search filter (1)
- secondary brain damage (1)
- secondary cancer (1)
- secondary lung tumors (1)
- self-diffusion (1)
- senescence (1)
- septal hypertrophy (1)
- septic (1)
- sequence imaging protocol (1)
- sequence variations (1)
- serogroup-Y (1)
- serotonin (1)
- serum (1)
- serum creatinine (1)
- severity (1)
- siRNA (1)
- signal transduction (1)
- signature (1)
- single-nucleotide polymorphisms (1)
- skewed (1)
- sleep-related breathing disorder (1)
- small fiber neuropathy (1)
- small interfering RNAs (1)
- small molecule (1)
- small-molecule Inhibitoren (1)
- small-molecule inhibitors (1)
- social interaction (1)
- socioeconomic (1)
- somatic mosaicism (1)
- soziodemographische Analyse (1)
- specific phobia (1)
- spectrum disorders (1)
- spezifische Phobie (1)
- spinal cord (1)
- spinal-cord (1)
- spontaneously hypertensive rats (1)
- sporadic Parkinson's disease (1)
- stage renal-disease (1)
- staib agar (1)
- standardization (1)
- startle disease (1)
- stem cell transplantation (1)
- stem cells (1)
- stent retriever stroke (1)
- steroids (1)
- streptozotocin (1)
- stroke register (1)
- stroke therapy (1)
- stroke treatment (1)
- stroke unit (1)
- stroke unit care (1)
- strongyloides infection (1)
- structural determination (1)
- structural disruption (1)
- substance dependence (1)
- substance use disorder (1)
- substantia nigra (1)
- subthalamic nucleus (1)
- sudden cardiac death (1)
- suicide attempt (1)
- superficial peroneal nerve (1)
- sural nerve (1)
- surrogate endpoints (1)
- surveillance (1)
- survival analysis (1)
- survivin (1)
- sustained fear (1)
- symptoms (1)
- synovial fluid (1)
- synovitis (1)
- synthetic mesh (1)
- systolic dysfunction (1)
- t-cells (1)
- tandem peptide (1)
- tanzania (1)
- tapered stem (1)
- targeted (1)
- task force (1)
- tenofovir disaproxil fumarate (1)
- term mortality (1)
- terminal bar (1)
- territory infaction (1)
- testicular neoplasms (1)
- therapeutic strategy (1)
- therapy simulation (1)
- thymic carcinoma (1)
- thymoma (1)
- thymus (1)
- tiefe Hirnstimulation (1)
- tinnitus (1)
- tissue engineering (1)
- tobramycin (1)
- transcranial direct current stimulation (1)
- transfection (1)
- transforming growth factor-beta 1 (1)
- translational stroke research (1)
- transplantation (1)
- transverse relaxation (1)
- treatment outcome (1)
- treatment response (1)
- treg cells (1)
- tremor (1)
- triamcinolone acetonide (1)
- tuberculous meningitis (1)
- tumor (1)
- tumor stem cells (1)
- tumor treating fields (1)
- tumor-draining lymph node (1)
- tumorigenesis (1)
- twin study (1)
- type-1 matrix (1)
- uPA (1)
- ubiquitin (1)
- umbilical hernia (1)
- univentricular heart (1)
- urinary bladder neoplasms (1)
- urinary protein excretion (1)
- urine (1)
- vaccination (1)
- vaccines (1)
- vaccinia virus (1)
- vacuum conditioning (1)
- variants (1)
- varicella (1)
- vascular calcification (1)
- vascular type (1)
- vasculitis (1)
- vasculopathy (1)
- vdr (1)
- vegetarians (1)
- velocity (1)
- ventral hernia (1)
- ventricular tachycardia (1)
- vertebral fractures (1)
- vincristine (1)
- viral replication (1)
- virions (1)
- virulence (1)
- visual (1)
- vitamin D (1)
- vitamin d (1)
- vitamin d receptor (1)
- vocal cord (1)
- volume determination (1)
- whole body MRI (1)
- whole-body (1)
- whole-brain radiotherapy (1)
- xiphophorus (1)
- zerebrale Ischämie (1)
- zervikale Lymphknotenmetastasen (1)
- zirkulierende Tumorzellen (1)
- zonal Hydrogels (1)
- Ängstlichkeit/Depressivität (1)
- Überexpression (1)
- Übergewicht (1)
- Überleben (1)
- α-galactosidase A (1)
- α-synuclein (1)
- β1 integrin (1)
- γ-H2AX (1)
Institute
- Medizinische Klinik und Poliklinik I (54)
- Neurologische Klinik und Poliklinik (48)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (36)
- Graduate School of Life Sciences (34)
- Medizinische Klinik und Poliklinik II (26)
- Theodor-Boveri-Institut für Biowissenschaften (17)
- Kinderklinik und Poliklinik (15)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (14)
- Klinik und Poliklinik für Nuklearmedizin (14)
- Pathologisches Institut (13)
Sonstige beteiligte Institutionen
- Institut für Medizinische Mikrobiologie und Hygiene der Eberhard-Karls-Universität Tübingen (1)
- Institut für Neurowissenschaften der Universität Mailand (1)
- Institut für diagnostische und interventionelle Radiologie, Klinikum Ingolstadt (1)
- Klinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie des Leopoldina Krankenhaus Schweinfurt (1)
- Lehrstuhl für Physiologische Chemie (1)
- Medizinische Hochschule Hannover, Kardiologie (1)
- Neurologische Klinik, Klinikum Ingolstadt (1)
- Sahin Lab, F.M. Kirby Neurobiology Center Boston Children’s Hospital, Department of Neurology, Harvard Medical School (1)
- Stellenbosch University - Division of Medical Virology (1)
- Tropenmedizin, Klinikum Würzburg Mitte gGmbH, Missioklinik (1)
ResearcherID
- N-2030-2015 (1)
- N-8985-2015 (1)
Introduction:
Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens.
Methods:
Protein physical interactions were screened using the yeast two-hybrid system. Co-affinity purifications and endogenous co-immunoprecipitation assays were performed to corroborate interactions. Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk.
Results:
A previously identified co-purifying protein with PALB2 was identified, MRG15 (MORF4L1 gene). Results in human, mouse and C. elegans models delineate molecular and functional relationships with BRCA2, PALB2, RAD51 and RPA1 that suggest a role for MRG15 in the repair of DNA double-strand breaks. Mrg15-deficient murine embryonic fibroblasts showed moderate sensitivity to g-irradiation relative to controls and reduced formation of Rad51 nuclear foci. Examination of mutants of MRG15 and BRCA2 C. elegans orthologs revealed phenocopy by accumulation of RPA-1 (human RPA1) nuclear foci and aberrant chromosomal compactions in meiotic cells.
However, no alterations or mutations were identified for MRG15/MORF4L1 in unclassified FA patients and BrCa familial cases. Finally, no significant associations between common MORF4L1 variants and BrCa risk for BRCA1 or BRCA2 mutation carriers were identified: rs7164529, Ptrend = 0.45 and 0.05, P2df = 0.51 and 0.14, respectively; and rs10519219, Ptrend = 0.92 and 0.72, P2df = 0.76 and 0.07, respectively.
Conclusions:
While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2
mutation carriers.
Context:
Adrenal tumors have a prevalence of around 2% in the general population. Adrenocortical carcinoma (ACC) is rare but accounts for 2–11% of incidentally discovered adrenal masses. Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology all providing unsatisfactory predictive values.
Objective:
Here we developed a novel steroid metabolomic approach, mass spectrometry-based steroid profiling followed by machine learning analysis, and examined its diagnostic value for the detection of adrenal malignancy.
Design:
Quantification of 32 distinct adrenal derived steroids was carried out by gas chromatography/mass spectrometry in 24-h urine samples from 102 ACA patients (age range 19–84 yr) and 45 ACC patients (20–80 yr). Underlying diagnosis was ascertained by histology and metastasis in ACC and by clinical follow-up [median duration 52 (range 26–201) months] without evidence of metastasis in ACA. Steroid excretion data were subjected to generalized matrix learning vector quantization (GMLVQ) to identify the most discriminative steroids.
Results:
Steroid profiling revealed a pattern of predominantly immature, early-stage steroidogenesis in ACC. GMLVQ analysis identified a subset of nine steroids that performed best in differentiating ACA from ACC. Receiver-operating characteristics analysis of GMLVQ results demonstrated sensitivity = specificity = 90% (area under the curve = 0.97) employing all 32 steroids and sensitivity = specificity = 88% (area under the curve = 0.96) when using only the nine most differentiating markers.
Conclusions:
Urine steroid metabolomics is a novel, highly sensitive, and specific biomarker tool for discriminating benign from malignant adrenal tumors, with obvious promise for the diagnostic work-up of patients with adrenal incidentalomas.
Background:
Inhibition of early platelet adhesion by blockade of glycoprotein-IB (GPIb) protects mice from ischemic stroke. To elucidate underlying mechanisms in-vivo, infarct development was followed by ultra-high field MRI at 17.6 Tesla.
Methods:
Cerebral infarction was induced by transient-middle-cerebral-artery-occlusion (tMCAO) for 1 hour in C57/BL6 control mice (N = 10) and mice treated with 100 mg Fab-fragments of the GPIb blocking antibody p0p/B 1 h after tMCAO (N = 10). To control for the effect of reperfusion, additional mice underwent permanent occlusion and received anti-GPIb treatment (N = 6; pMCAO) or remained without treatment (N = 3; pMCAO). MRI 2 h and 24 h after MCAO measured cerebral-blood-flow (CBF) by continuous arterial-spin labelling, the apparent-diffusion-coefficient (ADC), quantitative-T2 and T2-weighted imaging. All images were registered to a standard mouse brain MRI atlas and statistically analysed voxel-wise, and by cortico-subcortical ROI analysis.
Results:
Anti-GPIb treatment led to a relative increase of postischemic CBF vs. controls in the cortical territory of the MCA (2 h: 44.2 +/- 6.9 ml/100g/min versus 24 h: 60.5 +/- 8.4; p = 0.0012, F((1,18)) = 14.63) after tMCAO. Subcortical CBF 2 h after tMCAO was higher in anti-GPIb treated animals (45.3 +/- 5.9 vs. controls: 33.6 +/- 4.3; p = 0.04). In both regions, CBF findings were clearly related to a lower probability of infarction (Cortex/Subcortex of treated group: 35%/65% vs. controls: 95%/100%) and improved quantitative-T2 and ADC. After pMCAO, anti-GPIb treated mice developed similar infarcts preceded by severe irreversible hypoperfusion as controls after tMCAO indicating dependency of stroke protection on reperfusion.
Conclusion:
Blockade of platelet adhesion by anti-GPIb-Fab-fragments results in substantially improved CBF early during reperfusion. This finding was in exact spatial correspondence with the prevention of cerebral infarction and indicates in-vivo an increased patency of the microcirculation. Thus, progression of infarction during early ischemia and reperfusion can be mitigated by anti-platelet treatment.
Background:
Action myoclonus-renal failure syndrome is a hereditary form of progressive myoclonus epilepsy associated with renal failure. It is considered to be an autosomal-recessive disease related to loss-of-function mutations in SCARB2. We studied a German AMRF family, additionally showing signs of demyelinating polyneuropathy and dilated cardiomyopathy. To test the hypothesis whether isolated appearance of individual AMRF syndrome features could be related to heterozygote SCARB2 mutations, we screened for SCARB2 mutations in unrelated patients showing isolated AMRF features.
Methods:
In the AMRF family all exons of SCARB2 were analyzed by Sanger sequencing. The mutation screening of unrelated patients with isolated AMRF features affected by either epilepsy (n = 103, progressive myoclonus epilepsy or generalized epilepsy), demyelinating polyneuropathy (n = 103), renal failure (n = 192) or dilated cardiomyopathy (n = 85) was performed as high resolution melting curve analysis of the SCARB2 exons.
Results:
A novel homozygous 1 bp deletion (c.111delC) in SCARB2 was found by sequencing three affected homozygous siblings of the affected family. A heterozygous sister showed generalized seizures and reduction of nerve conduction velocity in her legs. No mutations were found in the epilepsy, renal failure or dilated cardiomyopathy samples. In the polyneuropathy sample two individuals with demyelinating disease were found to be carriers of a SCARB2 frameshift mutation (c.666delCCTTA).
Conclusions:
Our findings indicate that demyelinating polyneuropathy and dilated cardiomyopathy are part of the action myoclonus-renal failure syndrome. Moreover, they raise the possibility that in rare cases heterozygous SCARB2 mutations may be associated with PNP features.
Background:
Early-onset obsessive-compulsive disorder (OCD) is one of the more common mental illnesses of children and adolescents, with prevalence of 1% to 3%. Its manifestations often lead to severe impairment and to conflict in the family. In this review, we summarize the manifestations, comorbidity, pathophysiology, and course of this disease as well as current modes of diagnosis and treatment.
Methods:
We selectively review the relevant literature and the German-language guidelines for the diagnosis and treatment of mental illnesses in children and adolescents.
Results:
Obsessive-compulsive manifestations are of many types and cause severe impairment. Comorbid mental disturbances are present in as many as 70% of patients. The disease takes a chronic course in more than 40% of patients. Cognitive behavioral therapy is the treatment of first choice, followed by combination pharmacotherapy including selective serotonin reuptake inhibitors (SSRI) and then by SSRI alone.
Conclusion:
OCD often begins in childhood or adolescence. There are empirically based neurobiological and cognitive-behavioral models of its pathophysiology. Multiaxial diagnostic evaluation permits early diagnosis. Behavioral therapy and medications are highly effective treatments, but the disorder nonetheless takes a chronic course in a large percentage of patients.
Background:
Recent studies have shown that human ferritin can be used as a reporter of gene expression for magnetic resonance imaging (MRI). Bacteria also encode three classes of ferritin-type molecules with iron accumulation properties.
Methods and Findings:
Here, we investigated whether these bacterial ferritins can also be used as MRI reporter genes and which of the bacterial ferritins is the most suitable reporter. Bacterial ferritins were overexpressed in probiotic E. coli Nissle 1917. Cultures of these bacteria were analyzed and those generating highest MRI contrast were further investigated in tumor bearing mice. Among members of three classes of bacterial ferritin tested, bacterioferritin showed the most promise as a reporter gene. Although all three proteins accumulated similar amounts of iron when overexpressed individually, bacterioferritin showed the highest contrast change. By site-directed mutagenesis we also show that the heme iron, a unique part of the bacterioferritin molecule, is not critical for MRI contrast change. Tumor-specific induction of bacterioferritin-expression in colonized tumors resulted in contrast changes within the bacteria-colonized tumors.
Conclusions:
Our data suggest that colonization and gene expression by live vectors expressing bacterioferritin can be monitored by MRI due to contrast changes.
Background:
During the last years, (19)F-MRI and perfluorocarbon nanoemulsion (PFC) emerged as a powerful contrast agent methodology to track cells and to visualize inflammation. We applied this new modality to visualize deep tissue abscesses during acute and chronic phase of inflammation caused by Staphylococcus aureus infection.
Methodology and Principal Findings:
In this study, a murine thigh infection model was used to induce abscess formation and PFC or CLIO (cross linked ironoxides) was administered during acute or chronic phase of inflammation. 24 h after inoculation, the contrast agent accumulation was imaged at the site of infection by MRI. Measurements revealed a strong accumulation of PFC at the abscess rim at acute and chronic phase of infection. The pattern was similar to CLIO accumulation at chronic phase and formed a hollow sphere around the edema area. Histology revealed strong influx of neutrophils at the site of infection and to a smaller extend macrophages during acute phase and strong influx of macrophages at chronic phase of inflammation.
Conclusion and Significance:
We introduce (19)F-MRI in combination with PFC nanoemulsions as a new platform to visualize abscess formation in a murine thigh infection model of S. aureus. The possibility to track immune cells in vivo by this modality offers new opportunities to investigate host immune response, the efficacy of antibacterial therapies and the influence of virulence factors for pathogenesis.
Background
MicroRNAs, post-transcriptional regulators of eukaryotic gene expression, are implicated in host defense against pathogens. Viruses and bacteria have evolved strategies that suppress microRNA functions, resulting in a sustainable infection. In this work we report that Helicobacter pylori, a human stomach-colonizing bacterium responsible for severe gastric inflammatory diseases and gastric cancers, downregulates an embryonic stem cell microRNA cluster in proliferating gastric epithelial cells to achieve cell cycle arrest.
Results
Using a deep sequencing approach in the AGS cell line, a widely used cell culture model to recapitulate early events of H. pylori infection of gastric mucosa, we reveal that hsa-miR-372 is the most abundant microRNA expressed in this cell line, where, together with hsa-miR-373, it promotes cell proliferation by silencing large tumor suppressor homolog 2 (LATS2) gene expression. Shortly after H. pylori infection, miR-372 and miR-373 synthesis is highly inhibited, leading to the post-transcriptional release of LATS2 expression and thus, to a cell cycle arrest at the G1/S transition. This downregulation of a specific cell-cycle-regulating microRNA is dependent on the translocation of the bacterial effector CagA into the host cells, a mechanism highly associated with the development of severe atrophic gastritis and intestinal-type gastric carcinoma.
Conclusions
These data constitute a novel example of host-pathogen interplay involving microRNAs, and unveil the couple LATS2/miR-372 and miR-373 as an unexpected mechanism in infection-induced cell cycle arrest in proliferating gastric cells, which may be relevant in inhibition of gastric epithelium renewal, a major host defense mechanism against bacterial infections.