Experimental drillable magnesium phosphate cement is a promising alternative to conventional bone cements
Please always quote using this URN: urn:nbn:de:bvb:20-opus-236633
- Clinically used mineral bone cements lack high strength values, absorbability and drillability. Therefore, magnesium phosphate cements have recently received increasing attention as they unify a high mechanical performance with presumed degradation in vivo. To obtain a drillable cement formulation, farringtonite (Mg\(_3\)(PO\(_4\))\(_2\)) and magnesium oxide (MgO) were modified with the setting retardant phytic acid (C\(_6\)H\(_{18}\)O\(_{24}\)P\(_6\)). In a pre-testing series, 13 different compositions of magnesium phosphate cements wereClinically used mineral bone cements lack high strength values, absorbability and drillability. Therefore, magnesium phosphate cements have recently received increasing attention as they unify a high mechanical performance with presumed degradation in vivo. To obtain a drillable cement formulation, farringtonite (Mg\(_3\)(PO\(_4\))\(_2\)) and magnesium oxide (MgO) were modified with the setting retardant phytic acid (C\(_6\)H\(_{18}\)O\(_{24}\)P\(_6\)). In a pre-testing series, 13 different compositions of magnesium phosphate cements were analyzed concentrating on the clinical demands for application. Of these 13 composites, two cement formulations with different phytic acid content (22.5 wt% and 25 wt%) were identified to meet clinical demands. Both formulations were evaluated in terms of setting time, injectability, compressive strength, screw pullout tests and biomechanical tests in a clinically relevant fracture model. The cements were used as bone filler of a metaphyseal bone defect alone, and in combination with screws drilled through the cement. Both formulations achieved a setting time of 5 min 30 s and an injectability of 100%. Compressive strength was shown to be ~12–13 MPa and the overall displacement of the reduced fracture was <2 mm with and without screws. Maximum load until reduced fracture failure was ~2600 N for the cements only and ~3800 N for the combination with screws. Two new compositions of magnesium phosphate cements revealed high strength in clinically relevant biomechanical test set-ups and add clinically desired characteristics to its strength such as injectability and drillability.…
Author: | Philipp Heilig, Phoebe Sandner, Martin Cornelius Jordan, Rafael Gregor Jakubietz, Rainer Heribert Meffert, Uwe Gbureck, Stefanie Hoelscher-Doht |
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URN: | urn:nbn:de:bvb:20-opus-236633 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Unfall-, Hand-, Plastische und Wiederherstellungschirurgie (Chirurgische Klinik II) |
Medizinische Fakultät / Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde | |
Language: | English |
Parent Title (English): | Materials |
ISSN: | 1996-1944 |
Year of Completion: | 2021 |
Volume: | 14 |
Issue: | 8 |
Article Number: | 1925 |
Source: | Materials (2021) 14:8, 1925. https://doi.org/10.3390/ma14081925 |
DOI: | https://doi.org/10.3390/ma14081925 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | artificial bones; biomechanical evaluation; cyclic testing; drillable bone cement; inositol hexaphosphate; load to failure testing; magnesium phosphate cement; phytic acid; synbones; tibial head depression fracture |
Release Date: | 2022/08/08 |
Date of first Publication: | 2021/04/12 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |