Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch
Please always quote using this URN: urn:nbn:de:bvb:20-opus-312480
- The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site‐specifically conjugated to cysteines in a helical peptide by perfluoroarylation chemistry. In response to the photoisomerization (trans→cis) of the conjugated azobenzene with amber light, the secondary structure of the peptide was modulated from a disorganized into an amphiphilic helical structure.