Simultaneous structuring and mineralization of silk fibroin scaffolds
Please always quote using this URN: urn:nbn:de:bvb:20-opus-226427
- Silk fibroin is commonly used as scaffold material for tissue engineering applications. In combination with a mineralization with different calcium phosphate phases, it can also be applied as material for bone regeneration. Here, we present a study which was performed to produce mineralized silk fibroin scaffolds with controlled macroporosity. In contrast to former studies, our approach focused on a simultaneous gelation and mineralization of silk fibroin by immersion of frozen silk fibroin monoliths in acidic calcium phosphate solutions. ThisSilk fibroin is commonly used as scaffold material for tissue engineering applications. In combination with a mineralization with different calcium phosphate phases, it can also be applied as material for bone regeneration. Here, we present a study which was performed to produce mineralized silk fibroin scaffolds with controlled macroporosity. In contrast to former studies, our approach focused on a simultaneous gelation and mineralization of silk fibroin by immersion of frozen silk fibroin monoliths in acidic calcium phosphate solutions. This was achieved by thawing frozen silk fibroin monoliths in acidic calcium phosphate solution, leading to the precipitation of monocalcium phosphate within the silk fibroin matrix. In the second approach, a conversion of incorporated -tricalcium phosphate particles into brushite was successfully achieved. Furthermore, a controlled cryostructuring process of silk fibroin scaffolds was carried out leading to the formation of parallel-oriented pores with diameters of 30-50 mu m.…
Author: | Michaela Rödel, Katrin Baumann, Jürgen Groll, Uwe Gbureck |
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URN: | urn:nbn:de:bvb:20-opus-226427 |
Document Type: | Journal article |
Faculties: | Fakultät für Chemie und Pharmazie / Institut für Funktionsmaterialien und Biofabrikation |
Language: | English |
Parent Title (English): | Journal of Tissue Engineering |
Year of Completion: | 2018 |
Volume: | 9 |
Pagenumber: | 1-16 |
Source: | Journal of Tissue Engineering. 2018;9. |
DOI: | https://doi.org/10.1177/2041731418788509 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Tag: | Brushite; calcium phosphate; cryostructuring; hydrogel; mineralization; silk fibroin scaffolds |
Release Date: | 2023/02/08 |
Licence (German): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell 4.0 International |