Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
Please always quote using this URN: urn:nbn:de:bvb:20-opus-312295
- Increasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of fiveIncreasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole‐susceptible and fluconazole‐resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.…
Author: | Martina Raschig, Bernardo Ramírez‐Zavala, Johannes Wiest, Marco Saedtler, Marcus Gutmann, Ulrike Holzgrabe, Joachim Morschhäuser, Lorenz Meinel |
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URN: | urn:nbn:de:bvb:20-opus-312295 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
Fakultät für Chemie und Pharmazie / Institut für Pharmazie und Lebensmittelchemie | |
Language: | English |
Parent Title (English): | Archiv der Pharmazie |
Year of Completion: | 2023 |
Volume: | 356 |
Issue: | 2 |
Article Number: | e2200463 |
Source: | Archiv der Pharmazie 2023, 356(2):e2200463. DOI: 10.1002/ardp.202200463 |
DOI: | https://doi.org/10.1002/ardp.202200463 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 615 Pharmakologie, Therapeutik |
Tag: | Candida albicans; Candida auris; antifungal drug; azobenzenes |
Release Date: | 2023/06/16 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |