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Senescence and associated blood-brain barrier alterations in vitro
Please always quote using this URN: urn:nbn:de:bvb:20-opus-267435
- Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood-brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein presentProgressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood-brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within.…
Author: | Ellaine Salvador, Malgorzata Burek, Mario Löhr, Michiaki Nagai, Carsten Hagemann, Carola Y. Förster |
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URN: | urn:nbn:de:bvb:20-opus-267435 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004) | |
Language: | English |
Parent Title (English): | Histochemistry and Cell Biology |
ISSN: | 1432-119X |
Year of Completion: | 2021 |
Volume: | 156 |
Issue: | 3 |
Pagenumber: | 283-292 |
Source: | Histochemistry and Cell Biology 2021, 156(3):283-292. DOI: 10.1007/s00418-021-01992-z |
DOI: | https://doi.org/10.1007/s00418-021-01992-z |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/34043058 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | CNS diseases; aging; blood–brain barrier; in vitro model; senescence |
Release Date: | 2022/06/03 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |