Role of the kallikrein-kinin system in traumatic brain injury
Please always quote using this URN: urn:nbn:de:bvb:20-opus-118226
- Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite improvements in acute intensive care, there are currently no specific therapies to ameliorate the effects of TBI. Successful therapeutic strategies for TBI should target multiple pathophysiologic mechanisms that occur at different stages of brain injury. The kallikrein-kinin system is a promising therapeutic target for TBI as it mediates key pathologic events of traumatic brain damage, such as edema formation, inflammation, and thrombosis. Selective andTraumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite improvements in acute intensive care, there are currently no specific therapies to ameliorate the effects of TBI. Successful therapeutic strategies for TBI should target multiple pathophysiologic mechanisms that occur at different stages of brain injury. The kallikrein-kinin system is a promising therapeutic target for TBI as it mediates key pathologic events of traumatic brain damage, such as edema formation, inflammation, and thrombosis. Selective and specific kinin receptor antagonists and inhibitors of plasma kallikrein and coagulation factor XII have been developed, and have already shown therapeutic efficacy in animal models of stroke and TBI. However, conflicting preclinical evaluation, as well as limited and inconclusive data from clinical trials in TBI, suggests that caution should be taken before transferring observations made in animals to humans. This review summarizes current evidence on the pathologic significance of the kallikrein-kinin system during TBI in animal models and, where available, the experimental findings are compared with human data.…
Author: | Christiane Albert-Weissenberger, Stine Mencl, Sarah Hopp, Christoph Kleinschnitz, Anna-Leena Siren |
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URN: | urn:nbn:de:bvb:20-opus-118226 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
Medizinische Fakultät / Neurologische Klinik und Poliklinik | |
Language: | English |
Parent Title (English): | Frontiers in Cellular Neuroscience |
ISSN: | 1662-5102 |
Year of Completion: | 2014 |
Volume: | 8 |
Pagenumber: | 345 |
Source: | Frontiers in Cellular Neuroscience 8:345. doi: 10.3389/fncel.2014.00345 |
DOI: | https://doi.org/10.3389/fncel.2014.00345 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/25404891 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 617 Chirurgie und verwandte medizinische Fachrichtungen |
Tag: | bradykinin; factor XII; kallikrein–kinin system; kinin receptor; traumatic brain injury |
Release Date: | 2015/10/02 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |