Crystal structure of 5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one.
Please always quote using this URN: urn:nbn:de:bvb:20-opus-149627
- The title compound, C\(_{12}\)H\(_{9}\)N\(_{3}\)O, is an intermediate in the synthesis of the muscarinic M2 receptor antagonist AFDX-384. The seven-membered ring adopts a boat conformation and the dihedral angle between the planes of the aromatic rings is 41.51 (9)°. In the crystal, molecules are linked into [001] chains of alternating inversion dimers formed by pairs of N-H・・・O hydrogen bonds and pairs of N-H・・・N hydrogen bonds. In both cases, R\(_{2}\)\(^{2}\)(8) loops are generated.
Author: | Noura M. Riad, Darius P. Zlotos, Ulrike Holzgrabe |
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URN: | urn:nbn:de:bvb:20-opus-149627 |
Document Type: | Journal article |
Faculties: | Fakultät für Chemie und Pharmazie / Institut für Pharmazie und Lebensmittelchemie |
Language: | English |
Parent Title (English): | Acta Crystallographica Section E Crystallographic Communications |
Year of Completion: | 2015 |
Volume: | E71 |
Pagenumber: | o304-o305 |
Source: | Acta Crystallographica Section E Crystallographic Communications (2015). E71, o304-o305. DOI: 10.1107/S2056989015006817 |
DOI: | https://doi.org/10.1107/S2056989015006817 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/PMC4420050 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 548 Kristallografie |
Tag: | boat conformation; crystal structure; hydrogen bonding; pyridobenzodiazepine |
Release Date: | 2019/01/21 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |