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Nogo-A-deficient transgenic rats show deficits in higher cognitive functions, decreased anxiety, and altered circadian activity patterns
Please always quote using this URN: urn:nbn:de:bvb:20-opus-117073
- Decreased levels of Nogo-A-dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knockdown laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity, and activity patterns. Demonstrated is anDecreased levels of Nogo-A-dependent signaling have been shown to affect behavior and cognitive functions. In Nogo-A knockout and knockdown laboratory rodents, behavioral alterations were observed, possibly corresponding with human neuropsychiatric diseases of neurodevelopmental origin, particularly schizophrenia. This study offers further insight into behavioral manifestations of Nogo-A knockdown in laboratory rats, focusing on spatial and non-spatial cognition, anxiety levels, circadian rhythmicity, and activity patterns. Demonstrated is an impairment of cognitive functions and behavioral flexibility in a spatial active avoidance task, while non-spatial memory in a step-through avoidance task was spared. No signs of anhedonia, typical for schizophrenic patients, were observed in the animals. Some measures indicated lower anxiety levels in the Nogo-A-deficient group. Circadian rhythmicity in locomotor activity was preserved in the Nogo-A knockout rats and their circadian period (tau) did not differ from controls. However, daily activity patterns were slightly altered in the knockdown animals. We conclude that a reduction of Nogo-A levels induces changes in CNS development, manifested as subtle alterations in cognitive functions, emotionality, and activity patterns.…
Author: | Tomas Petrasek, Iva Prokopova, Martin Sladek, Kamila Weissova, Iveta Vojtechova, Stepan Bahnik, Anna Zemanova, Kai Schönig, Stefan Berger, Bjoern Tews, Dusan Bartsch, Martin E. Schwab, Alena Sumova, Ales Stuchlik |
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URN: | urn:nbn:de:bvb:20-opus-117073 |
Document Type: | Journal article |
Faculties: | Fakultät für Humanwissenschaften (Philos., Psycho., Erziehungs- u. Gesell.-Wissensch.) / Institut für Psychologie |
Language: | English |
Parent Title (English): | Frontiers in Behavioral Neuroscience |
Year of Completion: | 2014 |
Volume: | 8 |
Issue: | 90 |
Source: | Frontiers in Behavioral Neuroscience 8:90. doi: 10.3389/fnbeh.2014.00090 |
DOI: | https://doi.org/10.3389/fnbeh.2014.00090 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24672453 |
Dewey Decimal Classification: | 1 Philosophie und Psychologie / 15 Psychologie / 150 Psychologie |
Tag: | AAPA; Nogo-A; anhedonia; axon regeneration; carousel maze; circadian rhythmicity; down regulation; genetic deletion; messenger RNA; morris water maze; neophobia; neurite outgrowth inhibitor; passive avoidance; place avoidance task; synaptic plasticity; traumatic brain injury |
Release Date: | 2015/08/14 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |