Prevention of bone destruction by mechanical loading is not enhanced by the Bruton's tyrosine kinase inhibitor CC-292 in myeloma bone disease
Please always quote using this URN: urn:nbn:de:bvb:20-opus-284943
- Limiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton's tyrosine kinase inhibitor CC-292 (spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.LucLimiting bone resorption and regenerating bone tissue are treatment goals in myeloma bone disease (MMBD). Physical stimuli such as mechanical loading prevent bone destruction and enhance bone mass in the MOPC315.BM.Luc model of MMBD. It is unknown whether treatment with the Bruton's tyrosine kinase inhibitor CC-292 (spebrutinib), which regulates osteoclast differentiation and function, augments the anabolic effect of mechanical loading. CC-292 was administered alone and in combination with axial compressive tibial loading in the MOPC315.BM.Luc model for three weeks. However, neither CC-292 alone nor its use in combination with mechanical loading was more effective in reducing osteolytic bone disease or rescuing bone mass than mechanical stimuli alone, as evidenced by microcomputed tomography (microCT) and histomorphometric analysis. Further studies are needed to investigate novel anti-myeloma and anti-resorptive strategies in combination with physical stimuli to improve treatment of MMBD.…
Author: | Fani Ziouti, Maximilian Rummler, Beatrice Steyn, Tobias Thiele, Anne Seliger, Georg N. Duda, Bjarne Bogen, Bettina M. Willie, Franziska Jundt |
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URN: | urn:nbn:de:bvb:20-opus-284943 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Medizinische Klinik und Poliklinik II |
Medizinische Fakultät / Comprehensive Cancer Center Mainfranken | |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2021 |
Volume: | 22 |
Issue: | 8 |
Article Number: | 3840 |
Source: | International Journal of Molecular Sciences (2021) 22:8, 3840. https://doi.org/10.3390/ijms22083840 |
DOI: | https://doi.org/10.3390/ijms22083840 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Bruton's tyrosine kinase inhibitor CC-292; bone adaptation; cancer-induced bone disease; mechanical loading; multiple myeloma; skeletal mechanobiology |
Release Date: | 2023/06/23 |
Date of first Publication: | 2021/04/07 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |