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Micronucleus frequency in buccal mucosa cells of patients with neurodegenerative diseases
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-231430
- Neurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and analyzed DNA damage in the form of micronuclei in buccal mucosa samples. In addition, other parameters such as binucleated cells, karyolytic cells, and karyorrhectic cells were quantified. No relevant differences in DNA damage andNeurodegenerative diseases show an increase in prevalence and incidence, with the most prominent example being Alzheimer's disease. DNA damage has been suggested to play a role in the pathogenesis, but the exact mechanisms remain elusive. We enrolled 425 participants with and without neurodegenerative diseases and analyzed DNA damage in the form of micronuclei in buccal mucosa samples. In addition, other parameters such as binucleated cells, karyolytic cells, and karyorrhectic cells were quantified. No relevant differences in DNA damage and cytotoxicity markers were observed in patients compared to healthy participants. Furthermore, other parameters such as lifestyle factors and diseases were also investigated. Overall, this study could not identify a direct link between changes in buccal cells and neurogenerative diseases, but highlights the influence of lifestyle factors and diseases on the human buccal cytome.…
Autor(en): | Hauke Reimann, Helga Stopper, Thomas Polak, Martin Lauer, Martin J. Herrmann, Jürgen Deckert, Henning HintzscheORCiD |
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URN: | urn:nbn:de:bvb:20-opus-231430 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Scientific Reports |
Erscheinungsjahr: | 2020 |
Band / Jahrgang: | 10 |
Aufsatznummer: | 22196 |
Originalveröffentlichung / Quelle: | Scientific Reports (2020) 10:22196. https://doi.org/10.1038/s41598-020-78832-y |
DOI: | https://doi.org/10.1038/s41598-020-78832-y |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Alzheimers disease; DNA damage; assay; association; cognitive impairment; cytome biomarkers; diagnosis; life; peripheral-blood lymphocytes |
Datum der Freischaltung: | 21.04.2021 |
Open-Access-Publikationsfonds / Förderzeitraum 2020 | |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |