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Excretion of Ascaris lumbricoides following reduced‐intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole

Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-219608
  • Here, we present the unique case of a 51‐year‐old German patient with multiple myeloma excreting Ascaris lumbricoides in his stool five weeks after allogeneic hematopoietic stem cell transplantation. Stool analysis remained negative for the presence of eggs, and there was no eosinophilia in the peripheral blood at any time around stem cell transplantation. The patient was commenced on a three‐day treatment with mebendazole, which was well tolerated. No serious interactions with the concomitant post‐transplant medication or negative effects onHere, we present the unique case of a 51‐year‐old German patient with multiple myeloma excreting Ascaris lumbricoides in his stool five weeks after allogeneic hematopoietic stem cell transplantation. Stool analysis remained negative for the presence of eggs, and there was no eosinophilia in the peripheral blood at any time around stem cell transplantation. The patient was commenced on a three‐day treatment with mebendazole, which was well tolerated. No serious interactions with the concomitant post‐transplant medication or negative effects on the hematopoiesis were observed, and the myeloma still is in complete remission. To our knowledge, this is the first report on excretion of A lumbricoides in the context of allogeneic stem cell transplantation. The case is remarkable with view to the fact that the parasite has supposedly survived all courses of myeloma treatment including autologous and allogeneic conditioning. Parasitosis with A lumbricoides has a worldwide prevalence of about a billion and is extremely rare in northern Europe. Possibly the patient got infected during a trip to Egypt years before multiple myeloma was diagnosed.zeige mehrzeige weniger

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Autor(en): Verena Luber, Mathias LutzORCiD, Marianne Abele-Horn, Hermann EinseleORCiD, Götz Ulrich GrigoleitORCiD, Stephan MielkeORCiD
URN:urn:nbn:de:bvb:20-opus-219608
Dokumentart:Artikel / Aufsatz in einer Zeitschrift
Institute der Universität:Medizinische Fakultät / Institut für Hygiene und Mikrobiologie
Medizinische Fakultät / Medizinische Klinik und Poliklinik II
Sprache der Veröffentlichung:Englisch
Titel des übergeordneten Werkes / der Zeitschrift (Englisch):Transplant Infectious Disease
ISSN:1399-3062
Erscheinungsjahr:2019
Band / Jahrgang:22
Heft / Ausgabe:1
Aufsatznummer:e13224
Seitenangabe:1-4
Originalveröffentlichung / Quelle:Transplant Infectious Disease (2020), 22:1, e13224. doi:10.1111/tid.13224
DOI:https://doi.org/10.1111/tid.13224
Sonstige beteiligte Institutionen:Department of Laboratory Medicine and Medicine Huddinge, Karolinska Institutet and University Hospital, Stockholm, Sweden
Sonstige beteiligte Institutionen:Department of Hematology and Oncology, Sana Hospital Hof, Hof, Germany
Sonstige beteiligte Institutionen:Department of Medicine A, University Hospital of Münster, Münster, Germany
Allgemeine fachliche Zuordnung (DDC-Klassifikation):6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Freie Schlagwort(e):Ascaris lumbricoides; hematopoietic stem cell transplantation; mebendazole; multiple myeloma; mycophenolic acid; sirolimus
Datum der Freischaltung:22.12.2020
Lizenz (Deutsch):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International