MicroRNAs and long non-coding RNAs in adrenocortical carcinoma
Please always quote using this URN: urn:nbn:de:bvb:20-opus-281795
- Non-coding RNAs (ncRNAs) are a type of genetic material that do not encode proteins but regulate the gene expression at an epigenetic level, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The role played by ncRNAs in many physiological and pathological processes has gained attention during the last few decades, as they might be useful in the diagnosis, treatment and management of several human disorders, including endocrine and oncological diseases. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine cancer, stillNon-coding RNAs (ncRNAs) are a type of genetic material that do not encode proteins but regulate the gene expression at an epigenetic level, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). The role played by ncRNAs in many physiological and pathological processes has gained attention during the last few decades, as they might be useful in the diagnosis, treatment and management of several human disorders, including endocrine and oncological diseases. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine cancer, still characterized by high mortality and morbidity due to both endocrine and oncological complications. Despite the rarity of this disease, recently, the role of ncRNA has been quite extensively evaluated in ACC. In order to better explore the role of the ncRNA in human ACC, this review summarizes the current knowledge on ncRNA dysregulation in ACC and its potential role in the diagnosis, treatment, and management of this tumor.…
Author: | Mario Detomas, Claudia Pivonello, Bianca Pellegrini, Laura-Sophie Landwehr, Silviu Sbiera, Rosario Pivonello, Cristina L. Ronchi, Annamaria Colao, Barbara Altieri, Maria Cristina De Martino |
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URN: | urn:nbn:de:bvb:20-opus-281795 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Medizinische Klinik und Poliklinik I |
Language: | English |
Parent Title (English): | Cells |
ISSN: | 2073-4409 |
Year of Completion: | 2022 |
Volume: | 11 |
Issue: | 14 |
Article Number: | 2234 |
Source: | Cells (2022) 11:14, 2234. https://doi.org/10.3390/cells11142234 |
DOI: | https://doi.org/10.3390/cells11142234 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | ACC; adrenocortical adenoma; adrenocortical tumor; lncRNA; miRNA; prognostic markers |
Release Date: | 2023/02/14 |
Date of first Publication: | 2022/07/18 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |