Additive manufacturing of scaffolds with sub-micron filaments via melt electrospinning writing
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-254053
- The aim of this study was to explore the lower resolution limits of an electrohydrodynamic process combined with direct writing technology of polymer melts. Termed melt electrospinning writing, filaments are deposited layer-by-layer to produce discrete three-dimensional scaffolds for in vitro research. Through optimization of the parameters (flow rate, spinneret diameter, voltage, collector distance) for poly-ϵ-caprolactone, we could direct-write coherent scaffolds with ultrafine filaments, the smallest being 817 ± 165 nm. These low diameterThe aim of this study was to explore the lower resolution limits of an electrohydrodynamic process combined with direct writing technology of polymer melts. Termed melt electrospinning writing, filaments are deposited layer-by-layer to produce discrete three-dimensional scaffolds for in vitro research. Through optimization of the parameters (flow rate, spinneret diameter, voltage, collector distance) for poly-ϵ-caprolactone, we could direct-write coherent scaffolds with ultrafine filaments, the smallest being 817 ± 165 nm. These low diameter filaments were deposited to form box-structures with a periodicity of 100.6 ± 5.1 μm and a height of 80 μm (50 stacked filaments; 100 overlap at intersections). We also observed oriented crystalline regions within such ultrafine filaments after annealing at 55 °C. The scaffolds were printed upon NCO-sP(EO-stat-PO)-coated glass slide surfaces and withstood frequent liquid exchanges with negligible scaffold detachment for at least 10 days in vitro.…
Autor(en): | Gernot Hochleitner, Tomasz Jüngst, Toby D Brown, Kathrin Hahn, Claus Moseke, Franz Jakob, Paul D Dalton, Jürgen Groll |
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URN: | urn:nbn:de:bvb:20-opus-254053 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Lehrstuhl für Orthopädie |
Medizinische Fakultät / Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Biofabrication |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 7 |
Heft / Ausgabe: | 3 |
Aufsatznummer: | 035002 |
Originalveröffentlichung / Quelle: | Biofabrication 2015, 7(3):035002. DOI: 10.1088/1758-5090/7/3/035002 |
DOI: | https://doi.org/10.1088/1758-5090/7/3/035002 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | 3D printing; additive manufacturing; biodegradable polymers; microstructures; nanostructures |
Datum der Freischaltung: | 28.01.2022 |
EU-Projektnummer / Contract (GA) number: | 617989 |
OpenAIRE: | OpenAIRE |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |