Functional lung MRI for regional monitoring of patients with cystic fibrosis
Please always quote using this URN: urn:nbn:de:bvb:20-opus-172457
- Purpose To test quantitative functional lung MRI techniques in young adults with cystic fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a single inhalation of hypertonic saline in comparison to clinical routine pulmonary function tests. Materials and methods Sixteen clinically stable CF patients and 12 healthy volunteers prospectively underwent two functional lung MRI scans and pulmonary function tests before and 2h after a single treatment of inhaled hypertonic saline or without any treatment.Purpose To test quantitative functional lung MRI techniques in young adults with cystic fibrosis (CF) compared to healthy volunteers and to monitor immediate treatment effects of a single inhalation of hypertonic saline in comparison to clinical routine pulmonary function tests. Materials and methods Sixteen clinically stable CF patients and 12 healthy volunteers prospectively underwent two functional lung MRI scans and pulmonary function tests before and 2h after a single treatment of inhaled hypertonic saline or without any treatment. MRI-derived oxygen enhanced T1 relaxation measurements, fractional ventilation, first-pass perfusion parameters and a morpho-functional CF-MRI score were acquired. Results Compared to healthy controls functional lung MRI detected and quantified significantly increased ventilation heterogeneity in CF patients. Regional functional lung MRI measures of ventilation and perfusion as well as the CF-MRI score and pulmonary function tests could not detect a significant treatment effect two hours after a single treatment with hypertonic saline in young adults with CF (p>0.05). Conclusion This study shows the feasibility of functional lung MRI as a non-invasive, radiation-free tool for monitoring patients with CF.…
Author: | Till F. Kaireit, Sajoscha A. Sorrentino, Julius Renne, Christian Schoenfeld, Andreas Voskrebenzev, Marcel Gutberlet, Angela Schulz, Peter M. Jakob, Gesine Hansen, Frank Wacker, Tobias Welte, Burkhard Tümmler, Jens Vogel-Claussen |
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URN: | urn:nbn:de:bvb:20-opus-172457 |
Document Type: | Journal article |
Faculties: | Fakultät für Physik und Astronomie / Physikalisches Institut |
Language: | English |
Parent Title (English): | PLoS ONE |
Year of Completion: | 2017 |
Volume: | 12 |
Issue: | 12 |
Article Number: | e0187483 |
Source: | PLoS ONE (2017) 12(12):e0187483. https://doi.org/10.1371/journal.pone.0187483 |
DOI: | https://doi.org/10.1371/journal.pone.0187483 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/29216201 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
Tag: | Cystic fibrosis; Functional magnetic resonance imaging; Hypertonic; Magnetic resonance imaging; Oxygen; Physics; Pulmonary function; Pulmonary imaging; Quantum chronodynamics |
Release Date: | 2021/03/17 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |