Aplastic anemia as a roadmap for bone marrow failure: an overview and a clinical workflow
Please always quote using this URN: urn:nbn:de:bvb:20-opus-290440
- In recent years, it has become increasingly apparent that bone marrow (BM) failures and myeloid malignancy predisposition syndromes are characterized by a wide phenotypic spectrum and that these diseases must be considered in the differential diagnosis of children and adults with unexplained hematopoiesis defects. Clinically, hypocellular BM failure still represents a challenge in pathobiology-guided treatment. There are three fundamental topics that emerged from our review of the existing data. An exogenous stressor, an immune defect, and aIn recent years, it has become increasingly apparent that bone marrow (BM) failures and myeloid malignancy predisposition syndromes are characterized by a wide phenotypic spectrum and that these diseases must be considered in the differential diagnosis of children and adults with unexplained hematopoiesis defects. Clinically, hypocellular BM failure still represents a challenge in pathobiology-guided treatment. There are three fundamental topics that emerged from our review of the existing data. An exogenous stressor, an immune defect, and a constitutional genetic defect fuel a vicious cycle of hematopoietic stem cells, immune niches, and stroma compartments. A wide phenotypic spectrum exists for inherited and acquired BM failures and predispositions to myeloid malignancies. In order to effectively manage patients, it is crucial to establish the right diagnosis. New theragnostic windows can be revealed by exploring BM failure pathomechanisms.…
Author: | Antonio G. Solimando, Carmen Palumbo, Mary Victoria Pragnell, Max Bittrich, Antonella Argentiero, Markus Krebs |
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URN: | urn:nbn:de:bvb:20-opus-290440 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Urologische Klinik und Poliklinik |
Medizinische Fakultät / Medizinische Klinik und Poliklinik II | |
Medizinische Fakultät / Comprehensive Cancer Center Mainfranken | |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2022 |
Volume: | 23 |
Issue: | 19 |
Article Number: | 11765 |
Source: | International Journal of Molecular Sciences (2022) 23:19, 11765. https://doi.org/10.3390/ijms231911765 |
DOI: | https://doi.org/10.3390/ijms231911765 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | aplastic anemia; bone marrow failure; bone marrow immune-microenvironment; cytopenia; hematopoietic stem cells |
Release Date: | 2023/10/17 |
Date of first Publication: | 2022/10/04 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |