Senescence and associated blood-brain barrier alterations in vitro
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-267435
- Progressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood-brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein presentProgressive deterioration of the central nervous system (CNS) is commonly associated with aging. An important component of the neurovasculature is the blood-brain barrier (BBB), majorly made up of endothelial cells joined together by intercellular junctions. The relationship between senescence and changes in the BBB has not yet been thoroughly explored. Moreover, the lack of in vitro models for the study of the mechanisms involved in those changes impede further and more in-depth investigations in the field. For this reason, we herein present an in vitro model of the senescent BBB and an initial attempt to identify senescence-associated alterations within.…
Autor(en): | Ellaine Salvador, Malgorzata Burek, Mario Löhr, Michiaki Nagai, Carsten Hagemann, Carola Y. Förster |
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URN: | urn:nbn:de:bvb:20-opus-267435 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004) | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Histochemistry and Cell Biology |
ISSN: | 1432-119X |
Erscheinungsjahr: | 2021 |
Band / Jahrgang: | 156 |
Heft / Ausgabe: | 3 |
Seitenangabe: | 283-292 |
Originalveröffentlichung / Quelle: | Histochemistry and Cell Biology 2021, 156(3):283-292. DOI: 10.1007/s00418-021-01992-z |
DOI: | https://doi.org/10.1007/s00418-021-01992-z |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/34043058 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | CNS diseases; aging; blood–brain barrier; in vitro model; senescence |
Datum der Freischaltung: | 03.06.2022 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |