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The adhesion GPCR Latrophilin/CIRL shapes mechanosensation

Please always quote using this URN: urn:nbn:de:bvb:20-opus-148626
  • G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class. We show that dCirl shapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principalG-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class. We show that dCirl shapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principal mechanosensors of Drosophila. dCirl sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function. Our results indicate that aGPCR may generally process and modulate the perception of mechanical signals, linking these important stimuli to the sensory canon of the GPCR superfamily.show moreshow less

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Metadaten
Author: Nicole Scholz, Jennifer Gehring, Chonglin Guan, Dmitrij Ljaschenko, Robin Fischer, Vetrivel Lakshmanan, Robert J. Kittel, Tobias Langenhan
URN:urn:nbn:de:bvb:20-opus-148626
Document Type:Journal article
Faculties:Medizinische Fakultät / Physiologisches Institut
Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften
Language:English
Parent Title (English):Cell Reports
Year of Completion:2015
Volume:11
Pagenumber:866-874
Source:Cell Reports 2015, 11, 866-874. DOI: 10.1016/j.celrep.2015.04.008
DOI:https://doi.org/10.1016/j.celrep.2015.04.008
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Johnstons organ; \(\alpha\)-latrotoxin; binding; chordotonal organs; domain; drosophila larvae; hearing; ligand CD55; protein-coupled receptors; shear stress
Release Date:2018/11/15
Licence (German):License LogoCC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International