A complete compilation of matrix metalloproteinase expression in human malignant gliomas
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-123982
- Glioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases (MMPs) were found in glioblastoma (GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma (LGA) and normal brain samples, indicating a role in malignant progression. AGlioblastomas are characterized by an aggressive local growth pattern, a marked degree of invasiveness and poor prognosis. Tumor invasiveness is facilitated by the increased activity of proteolytic enzymes which are involved in destruction of the extracellular matrix of the surrounding healthy brain tissue. Elevated levels of matrix metalloproteinases (MMPs) were found in glioblastoma (GBM) cell-lines, as well as in GBM biopsies as compared with low-grade astrocytoma (LGA) and normal brain samples, indicating a role in malignant progression. A careful review of the available literature revealed that both the expression and role of several of the 23 human MMP proteins is controversely discussed and for some there are no data available at all. We therefore screened a panel of 15 LGA and 15 GBM biopsy samples for those MMPs for which there is either no, very limited or even contradictory data available. Hence, this is the first complete compilation of the expression pattern of all 23 human MMPs in astrocytic tumors. This study will support a better understanding of the specific expression patterns and interaction of proteolytic enzymes in malignant human glioma and may provide additional starting points for targeted patient therapy.…
Autor(en): | Carsten Hagemann, Jelena Anacker, Ralf-Ingo Ernestus, Giles H. Vince |
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URN: | urn:nbn:de:bvb:20-opus-123982 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Frauenklinik und Poliklinik |
Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | World Journal of Clinical Oncology |
Erscheinungsjahr: | 2012 |
Band / Jahrgang: | 3 |
Heft / Ausgabe: | 5 |
Seitenangabe: | 67-79 |
Originalveröffentlichung / Quelle: | World Journal of Clinical Oncology 2012; 3(5):67-79. doi:10.5306/wjco.v3.i5.67 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/PMC3349915 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 616 Krankheiten |
Freie Schlagwort(e): | astrocytic tumor; expression pattern; glioblastoma cell-lines; glioblastoma multiforme; matrix metalloproteinase |
Datum der Freischaltung: | 12.01.2016 |
Lizenz (Deutsch): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |