Serjanic acid improves immunometabolic markers in a diet-induced obesity mouse model
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- Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A dietPlant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.…
Autor(en): | Gustavo Gutiérrez, Deisy Giraldo-Dávila, Marianny Y. Combariza, Ulrike Holzgrabe, Jorge Humberto Tabares-Guevara, José Robinson Ramírez-Pineda, Sergio Acín, Diana Lorena Muñoz, Guillermo Montoya, Norman Balcazar |
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URN: | urn:nbn:de:bvb:20-opus-203253 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Fakultät für Chemie und Pharmazie / Institut für Pharmazie und Lebensmittelchemie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Molecules |
ISSN: | 1420-3049 |
Erscheinungsjahr: | 2020 |
Band / Jahrgang: | 25 |
Heft / Ausgabe: | 7 |
Aufsatznummer: | 1486 |
Originalveröffentlichung / Quelle: | Molecules (2020) 25:7, 1486. https://doi.org/10.3390/molecules25071486 |
DOI: | https://doi.org/10.3390/molecules25071486 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 615 Pharmakologie, Therapeutik |
Freie Schlagwort(e): | Cecropia telenitida; serjanic acid; type 2 diabetes |
Datum der Freischaltung: | 19.05.2022 |
Datum der Erstveröffentlichung: | 25.03.2020 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |