Ileal interposition in rats with experimental type 2 like diabetes improves glycemic control independently of glucose absorption
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- Bariatric operations in obese patients with type 2 diabetes often improve diabetes before weight loss is observed. In patients mainly Roux-en-Y-gastric bypass with partial stomach resection is performed. Duodenojejunal bypass (DJB) and ileal interposition (IIP) are employed in animal experiments. Due to increased glucose exposition of L-cells located in distal ileum, all bariatric surgery procedures lead to higher secretion of antidiabetic glucagon like peptide-1 (GLP-1) after glucose gavage. After DJB also downregulation ofBariatric operations in obese patients with type 2 diabetes often improve diabetes before weight loss is observed. In patients mainly Roux-en-Y-gastric bypass with partial stomach resection is performed. Duodenojejunal bypass (DJB) and ileal interposition (IIP) are employed in animal experiments. Due to increased glucose exposition of L-cells located in distal ileum, all bariatric surgery procedures lead to higher secretion of antidiabetic glucagon like peptide-1 (GLP-1) after glucose gavage. After DJB also downregulation of Na\(^{+}\)-D-glucose cotransporter SGLT1 was observed. This suggested a direct contribution of decreased glucose absorption to the antidiabetic effect of bariatric surgery. To investigate whether glucose absorption is also decreased after IIP, we induced diabetes with decreased glucose tolerance and insulin sensitivity in male rats and investigated effects of IIP on diabetes and SGLT1. After IIP, we observed weight-independent improvement of glucose tolerance, increased insulin sensitivity, and increased plasma GLP-1 after glucose gavage. The interposed ileum was increased in diameter and showed increased length of villi, hyperplasia of the epithelial layer, and increased number of L-cells. The amount of SGLT1-mediated glucose uptake in interposed ileum was increased 2-fold reaching the same level as in jejunum. Thus, improvement of glycemic control by bariatric surgery does not require decreased glucose absorption.…
Autor(en): | Christian Ferdinand Jurowich, Christoph Otto, Prashanth Reddy Rikkala, Nicole Wagner, Ivana Vrhovac, Ivan Sabolić, Christoph-Thomas Germer, Hermann Koepsell |
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URN: | urn:nbn:de:bvb:20-opus-149166 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) |
Medizinische Fakultät / Institut für Anatomie und Zellbiologie | |
Fakultät für Biologie / Julius-von-Sachs-Institut für Biowissenschaften | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Journal of Diabetes Research |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 2015 |
Heft / Ausgabe: | 490365 |
Originalveröffentlichung / Quelle: | Journal of Diabetes Research Volume 2015, Article ID 490365 (2015). DOI: 10.1155/2015/490365 |
DOI: | https://doi.org/10.1155/2015/490365 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Y-gastric bypass; bariatric surgery; biliopancreatic diversion; body weight; cotransporter SGLT1; duodenal jejunal bypass; food intake; glucagon like peptide-1; gut hormones; intestinal glucose |
Datum der Freischaltung: | 27.11.2018 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |