The adhesion GPCR Latrophilin/CIRL shapes mechanosensation
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-148626
- G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class. We show that dCirl shapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principalG-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes the Drosophila aGPCR Latrophilin/dCirl, a prototype member of this enigmatic receptor class. We show that dCirl shapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principal mechanosensors of Drosophila. dCirl sensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function. Our results indicate that aGPCR may generally process and modulate the perception of mechanical signals, linking these important stimuli to the sensory canon of the GPCR superfamily.…
Autor(en): | Nicole Scholz, Jennifer Gehring, Chonglin Guan, Dmitrij Ljaschenko, Robin Fischer, Vetrivel Lakshmanan, Robert J. Kittel, Tobias Langenhan |
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URN: | urn:nbn:de:bvb:20-opus-148626 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Physiologisches Institut |
Fakultät für Biologie / Theodor-Boveri-Institut für Biowissenschaften | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Cell Reports |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 11 |
Seitenangabe: | 866-874 |
Originalveröffentlichung / Quelle: | Cell Reports 2015, 11, 866-874. DOI: 10.1016/j.celrep.2015.04.008 |
DOI: | https://doi.org/10.1016/j.celrep.2015.04.008 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Johnstons organ; \(\alpha\)-latrotoxin; binding; chordotonal organs; domain; drosophila larvae; hearing; ligand CD55; protein-coupled receptors; shear stress |
Datum der Freischaltung: | 15.11.2018 |
Lizenz (Deutsch): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International |