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cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-162324
- The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling exists. Here, we suggest a possible biophysical basis for the site-specific regulation of synaptic plasticity by cAMP, a highly diffusible small molecule that transforms the physiology of synapses in a local and specific manner. By exploiting the octopaminergic system of Drosophila, which mediatesThe second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling exists. Here, we suggest a possible biophysical basis for the site-specific regulation of synaptic plasticity by cAMP, a highly diffusible small molecule that transforms the physiology of synapses in a local and specific manner. By exploiting the octopaminergic system of Drosophila, which mediates structural synaptic plasticity via a cAMP-dependent pathway, we demonstrate the existence of local cAMP signaling compartments of micrometer dimensions within single motor neurons. In addition, we provide evidence that heterogeneous octopamine receptor localization, coupled with local differences in phosphodiesterase activity, underlies the observed differences in cAMP signaling in the axon, cell body, and boutons.…
Autor(en): | Isabella Maiellaro, Martin J. Lohse, Robert J. Kitte, Davide Calebiro |
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URN: | urn:nbn:de:bvb:20-opus-162324 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
Medizinische Fakultät / Physiologisches Institut | |
Fakultät für Biologie / Rudolf-Virchow-Zentrum | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Cell Reports |
Erscheinungsjahr: | 2016 |
Band / Jahrgang: | 17 |
Heft / Ausgabe: | 5 |
Seitenangabe: | 1238-1246 |
Originalveröffentlichung / Quelle: | Cell Reports 17, 1238–1246 doi:10.1016/j.celrep.2016.09.090 |
DOI: | https://doi.org/10.1016/j.celrep.2016.09.090 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 612 Humanphysiologie |
Freie Schlagwort(e): | FRET; GPCR; PDE; active zone; cAMP; dunce; octopamine; synaptic plasticity |
Datum der Freischaltung: | 13.07.2018 |
EU-Projektnummer / Contract (GA) number: | 324612 |
OpenAIRE: | OpenAIRE |
Lizenz (Deutsch): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International |