Increase in CTGF mRNA expression by respiratory syncytial virus infection is abrogated by caffeine in lung epithelial cells
Please always quote using this URN: urn:nbn:de:bvb:20-opus-230909
- Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV-infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV-mediated increase in CTGF mRNA. RSV may be involvedRespiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infection in early childhood. Underlying pathomechanisms of elevated pulmonary morbidity in later infancy are largely unknown. We found that RSV-infected H441 cells showed increased mRNA expression of connective tissue growth factor (CTGF), a key factor in airway remodeling. Additional dexamethasone treatment led to further elevated mRNA levels, indicating additive effects. Caffeine treatment prevented RSV-mediated increase in CTGF mRNA. RSV may be involved in airway remodeling processes by increasing CTGF mRNA expression. Caffeine might abrogate these negative effects and thereby help to restore lung homeostasis.…
Author: | Steffen Kunzmann, Christine Krempl, Silvia Seidenspinner, Kirsten Glaser, Christian P. Speer, Markus Fehrholz |
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URN: | urn:nbn:de:bvb:20-opus-230909 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Kinderklinik und Poliklinik |
Medizinische Fakultät / Institut für Virologie und Immunbiologie | |
Language: | English |
Parent Title (English): | Influenza and Other Respiratory Viruses |
Year of Completion: | 2018 |
Volume: | 12 |
Pagenumber: | 662-666 |
Source: | Influenza and Other Respiratory Viruses (2018) 12:662-666. https://doi.org/10.1111/irv.12561 |
DOI: | https://doi.org/10.1111/irv.12561 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | CCN2; caffeine; dexamethasone; lung remodeling; poly(I:C) |
Release Date: | 2024/09/04 |
Licence (German): | ![]() |