Refine
Year of publication
- 2024 (23)
- 2023 (440)
- 2022 (810)
- 2021 (893)
- 2020 (613)
- 2019 (430)
- 2018 (358)
- 2017 (368)
- 2016 (547)
- 2015 (427)
- 2014 (435)
- 2013 (383)
- 2012 (364)
- 2011 (211)
- 2010 (89)
- 2009 (8)
- 2008 (8)
- 2007 (6)
- 2006 (4)
- 2005 (2)
- 2004 (1)
- 2003 (1)
- 2002 (1)
- 2000 (1)
- 1995 (1)
- 1994 (123)
- 1993 (131)
- 1992 (103)
- 1991 (104)
- 1990 (78)
- 1989 (80)
- 1988 (69)
- 1987 (56)
- 1986 (57)
- 1985 (34)
- 1984 (33)
- 1983 (21)
- 1982 (27)
- 1981 (15)
- 1980 (12)
- 1979 (18)
- 1978 (15)
- 1977 (13)
- 1976 (8)
- 1975 (11)
- 1974 (8)
- 1973 (10)
- 1972 (14)
- 1971 (7)
- 1970 (6)
- 1969 (5)
- 1968 (1)
Document Type
- Journal article (7493) (remove)
Language
- English (7493) (remove)
Keywords
- Toxikologie (110)
- Medizin (94)
- inflammation (85)
- Biochemie (81)
- Anorganische Chemie (66)
- cancer (62)
- gene expression (62)
- Organische Chemie (59)
- Infektionsbiologie (57)
- apoptosis (53)
- expression (53)
- COVID-19 (51)
- Biologie (50)
- Psychologie (49)
- machine learning (49)
- Physiologische Chemie (46)
- Hadron-Hadron scattering (experiments) (45)
- breast cancer (45)
- depression (45)
- multiple myeloma (44)
- children (43)
- therapy (40)
- Neurobiologie (39)
- virtual reality (37)
- infection (36)
- anxiety (35)
- ischemic stroke (35)
- mice (35)
- T cells (34)
- Virologie (34)
- boron (34)
- stroke (33)
- cytokines (32)
- remote sensing (32)
- melanoma (31)
- SARS-CoV-2 (30)
- biomarker (30)
- brain (30)
- multiple sclerosis (30)
- oxidative stress (30)
- prostate cancer (30)
- Germany (29)
- metabolism (29)
- biodiversity (28)
- gene (28)
- heart failure (28)
- magnetic resonance imaging (28)
- DNA damage (27)
- evolution (27)
- Chirurgie (26)
- PET (26)
- climate change (26)
- deep learning (26)
- in vitro (26)
- macrophages (26)
- High energy physics (25)
- Parton Distributions (25)
- genetics (25)
- phosphorylation (25)
- protein (25)
- DNA methylation (24)
- MRI (24)
- diagnosis (24)
- medicine (24)
- survival (24)
- B cells (23)
- Escherichia coli (23)
- Fabry disease (23)
- identification (23)
- mortality (23)
- Parkinson’s disease (22)
- autophagy (22)
- disease (22)
- immunotherapy (22)
- positron emission tomography (22)
- Candida albicans (21)
- Immunologie (21)
- blood (21)
- chronic kidney disease (21)
- neuroinflammation (21)
- obesity (21)
- physics (21)
- 3D printing (20)
- ADHD (20)
- ATLAS detector (20)
- activation (20)
- mouse (20)
- physical activity (20)
- quality of life (20)
- radiotherapy (20)
- surgery (20)
- tissue engineering (20)
- Chemie (19)
- DNA (19)
- behavior (19)
- classification (19)
- endothelial cells (19)
- immunohistochemistry (19)
- management (19)
- mouse model (19)
- prognosis (19)
- Parkinson's disease (18)
- binding (18)
- dendritic cells (18)
- fluorescence (18)
- mouse models (18)
- pain (18)
- platelets (18)
- regulatory T cells (18)
- stem cells (18)
- theranostics (18)
- time series (18)
- CXCR4 (17)
- EEG (17)
- Expression (17)
- HIV (17)
- RNA (17)
- aging (17)
- antibodies (17)
- biology (17)
- colorectal cancer (17)
- deep brain stimulation (17)
- differentiation (17)
- epidemiology (17)
- metastasis (17)
- mitochondria (17)
- perception (17)
- psychology (17)
- toxicity (17)
- validation (17)
- Staphylococcus aureus (16)
- artificial intelligence (16)
- biomarkers (16)
- blood pressure (16)
- blood-brain barrier (16)
- cells (16)
- cytotoxicity (16)
- epithelial cells (16)
- messenger RNA (16)
- model (16)
- myocardial infarction (16)
- prevalence (16)
- resistance (16)
- transcriptome (16)
- Decay (15)
- Positronen-Emissions-Tomografie (15)
- chemotherapy (15)
- cytoskeleton (15)
- escherichia coli (15)
- hadron-hadron scattering (15)
- mental health (15)
- mutation (15)
- neurons (15)
- osteoporosis (15)
- proton-proton collision (15)
- signal transduction (15)
- Cytologie (14)
- Drosophila melanogaster (14)
- Extension (14)
- Higgs boson (14)
- P300 (14)
- Sentinel-2 (14)
- adrenocortical carcinoma (14)
- angiogenesis (14)
- attention (14)
- bone (14)
- cell death (14)
- foraging (14)
- guidelines (14)
- heart (14)
- imaging (14)
- immune response (14)
- in vivo (14)
- in-vivo (14)
- learning (14)
- luminescence (14)
- mechanisms (14)
- neuropathic pain (14)
- neuroprotection (14)
- prediction (14)
- proteins (14)
- rat (14)
- schizophrenia (14)
- sepsis (14)
- topological insulators (14)
- virulence (14)
- vision (14)
- Apis mellifera (13)
- LHC (13)
- Medicine (13)
- Neisseria meningitidis (13)
- Physics (13)
- association (13)
- bacteria (13)
- bees (13)
- case report (13)
- cell staining (13)
- chemistry (13)
- crystal structure (13)
- echocardiography (13)
- extracellular matrix (13)
- flow cytometry (13)
- honey bees (13)
- human (13)
- land use (13)
- metaanalysis (13)
- molecular docking (13)
- monocytes (13)
- ovarian cancer (13)
- recurrence (13)
- risk factors (13)
- stress (13)
- transcription (13)
- transcription factors (13)
- tumor (13)
- Activation (12)
- Drosophila (12)
- MODIS (12)
- Merkel cell carcinoma (12)
- PET/CT (12)
- blood–brain barrier (12)
- circadian clock (12)
- dopamine (12)
- epigenetics (12)
- gene regulation (12)
- genome (12)
- humans (12)
- in-vitro (12)
- inorganic chemistry (12)
- mRNA (12)
- metabolomics (12)
- microRNA (12)
- neurodegeneration (12)
- nutrition (12)
- proliferation (12)
- structure elucidation (12)
- treatment (12)
- ++ (11)
- Aspergillus (11)
- Aspergillus fumigatus (11)
- BDNF (11)
- DNA repair (11)
- PRRT (11)
- Squark (11)
- Tanzania (11)
- additive manufacturing (11)
- atherosclerosis (11)
- cancer treatment (11)
- conservation (11)
- diet (11)
- emotion (11)
- event-related potentials (11)
- exercise (11)
- fMRI (11)
- fibrosis (11)
- follow-up (11)
- fracture (11)
- fungi (11)
- glioblastoma (11)
- glioblastoma multiforme (11)
- hippocampus (11)
- honeybee (11)
- inhibition (11)
- lung cancer (11)
- lymphoma (11)
- mass spectrometry (11)
- measles virus (11)
- membrane proteins (11)
- memory (11)
- miRNA (11)
- migration (11)
- nervous system (11)
- neurology (11)
- optogenetics (11)
- osteoarthritis (11)
- proteomics (11)
- randomized controlled trial (11)
- reliability (11)
- simulation (11)
- tight junctions (11)
- total knee arthroplasty (11)
- traumatic brain injury (11)
- tumor microenvironment (11)
- vitamin D (11)
- Alzheimer’s disease (10)
- PSMA (10)
- Trypanosoma brucei (10)
- adolescents (10)
- animal model (10)
- antimicrobial resistance (10)
- atrial fibrillation (10)
- cardiomyopathy (10)
- complex (10)
- diabetes (10)
- electronic properties and materials (10)
- emotions (10)
- fear (10)
- genome-wide association (10)
- global change (10)
- growth (10)
- insects (10)
- lymph nodes (10)
- lymphocytes (10)
- melt electrowriting (10)
- metagenomics (10)
- microbiome (10)
- microglia (10)
- mushroom body (10)
- neuroendocrine tumor (10)
- neutrophils (10)
- performance (10)
- polymers (10)
- pregnancy (10)
- receptor (10)
- relapse (10)
- review (10)
- risk (10)
- safety (10)
- self-assembly (10)
- serotonin (10)
- sphingolipids (10)
- transplantation (10)
- Boron (9)
- Cancer (9)
- Depression (9)
- Google Earth Engine (9)
- Krebs <Medizin> (9)
- RNA-seq (9)
- Schwertkärpfling (9)
- Sentinel-1 (9)
- T-cells (9)
- active zone (9)
- age (9)
- amygdala (9)
- ants (9)
- asthma (9)
- autoimmunity (9)
- bipolar disorder (9)
- boranes (9)
- central nervous system (9)
- cerebrospinal fluid (9)
- clinical trial (9)
- database (9)
- density functional calculations (9)
- diversity (9)
- dosimetry (9)
- dynamics (9)
- ecology (9)
- ecosystem services (9)
- energy (9)
- enzyme replacement therapy (9)
- fear conditioning (9)
- forest (9)
- hemodialysis (9)
- hypoxia (9)
- immunology (9)
- ischemia (9)
- mutations (9)
- nanoparticles (9)
- neural networks (9)
- olfaction (9)
- outcome (9)
- pancreatic cancer (9)
- pathogens (9)
- phenotype (9)
- plasticity (9)
- pollination (9)
- polymorphism (9)
- prefrontal cortex (9)
- preterm infants (9)
- rats (9)
- reveals (9)
- synaptic plasticity (9)
- systematic review (9)
- systematic uncertainty (9)
- temperature (9)
- translation (9)
- tumors (9)
- type 2 diabetes (9)
- ubiquitin (9)
- walking (9)
- Adenosine receptors (8)
- Alps (8)
- Apoptosis (8)
- Beyond Standard Model (8)
- Cross-Section (8)
- EAE (8)
- HNSCC (8)
- LASP1 (8)
- Landsat (8)
- MS (8)
- MYC (8)
- Mass (8)
- Mice (8)
- Model (8)
- NK cells (8)
- Parton distributions (8)
- TNF (8)
- Therapy (8)
- West Africa (8)
- Xiphophorus (8)
- actin (8)
- acute kidney injury (8)
- adolescence (8)
- amyotrophic lateral sclerosis (8)
- analysis of variance (8)
- animal models (8)
- antibiotics (8)
- aromaticity (8)
- biofabrication (8)
- body size (8)
- borylation (8)
- calcium (8)
- cardiovascular disease (8)
- cartilage (8)
- cell biology (8)
- cell cycle (8)
- chromatin (8)
- cortisol (8)
- cytotoxic T cells (8)
- decay (8)
- decision making (8)
- development (8)
- earth observation (8)
- education (8)
- electroencephalography (8)
- emotion regulation (8)
- fatigue (8)
- fluorescence microscopy (8)
- forest management (8)
- head and neck cancer (8)
- heart rate (8)
- high energy physics (8)
- hypertension (8)
- impact (8)
- in vivo imaging (8)
- induced pluripotent stem cells (8)
- jet energy scale (8)
- kidney (8)
- kinematic alignment (8)
- kinetics (8)
- mHealth (8)
- major depression (8)
- mechanism (8)
- mesenchymal stem cells (8)
- microscopy (8)
- molecular biology (8)
- molecular imaging (8)
- navigation (8)
- neuroscience (8)
- next generation sequencing (8)
- nitric oxide (8)
- oncology (8)
- oncolytic virus (8)
- organoids (8)
- pathway (8)
- periodontitis (8)
- platelet (8)
- platelet activation (8)
- pollen (8)
- polycyclic aromatic hydrocarbons (8)
- prevention (8)
- progression (8)
- quality assurance (8)
- radioligand therapy (8)
- reactive oxygen species (8)
- reconstruction (8)
- regulation (8)
- rehabilitation (8)
- replication (8)
- rheumatoid arthritis (8)
- serum (8)
- signaling (8)
- subthalamic nucleus (8)
- super-resolution microscopy (8)
- technology (8)
- tinnitus (8)
- transcriptomics (8)
- transmission (8)
- water oxidation (8)
- ALS (7)
- ATLAS (7)
- Arabidopsis thaliana (7)
- Gehirn (7)
- NDVI (7)
- Neisseria gonorrhoeae (7)
- Pain (7)
- Physik (7)
- SAR (7)
- SPECT (7)
- Supersymmetry (7)
- Survival (7)
- Transcription (7)
- Trypanosoma (7)
- United States (7)
- X-ray crystallography (7)
- acute ischemic stroke (7)
- agriculture (7)
- animal behavior (7)
- antibacterial activity (7)
- astrocytes (7)
- autoantibodies (7)
- bioprinting (7)
- biosynthesis (7)
- blood flow (7)
- body mass index (7)
- cell membranes (7)
- central complex (7)
- chemokine receptor (7)
- chronic heart failure (7)
- circadian rhythms (7)
- coherence (7)
- comparative genomics (7)
- dSTORM (7)
- decision-making (7)
- developmental biology (7)
- diabetes mellitus (7)
- diborenes (7)
- domain (7)
- drought (7)
- efficacy (7)
- embodiment (7)
- endurance (7)
- experimental autoimmune encephalomyelitis (7)
- extracellular vesicles (7)
- fibromyalgia syndrome (7)
- fluorescent probes (7)
- gastric cancer (7)
- genes (7)
- genomics (7)
- glycine receptor (7)
- histology (7)
- human behaviour (7)
- hydrogels (7)
- hypophosphatasia (7)
- immersion (7)
- immune evasion (7)
- immunofluorescence (7)
- immunomodulation (7)
- immunoprecipitation (7)
- inhibitor (7)
- insect (7)
- luciferase (7)
- mechanotransduction (7)
- meiosis (7)
- melt electrospinning writing (7)
- microenvironment (7)
- multicenter (7)
- optimization (7)
- panic disorder (7)
- peripheral nervous system (7)
- permafrost (7)
- photocatalysis (7)
- platelet aggregation (7)
- population (7)
- psychiatric disorders (7)
- public health (7)
- random forest (7)
- recognition (7)
- responses (7)
- semiconductors (7)
- senescence (7)
- sex differences (7)
- species richness (7)
- spectroscopy (7)
- spinal muscular atrophy (7)
- symbiosis (7)
- synthesis (7)
- telomeres (7)
- thrombosis (7)
- trial (7)
- water (7)
- wearable (7)
- zebrafish (7)
- Alzheimer's disease (6)
- Chrysomelidae (6)
- Covid-19 (6)
- DNA binding (6)
- ELISPOT (6)
- Earth observation (6)
- Echinococcus (6)
- Ernährung (6)
- Europe (6)
- Evolution (6)
- Gluino Production (6)
- Hadron colliders (6)
- HeLa cells (6)
- Higgs physics (6)
- Inflammation (6)
- Large Hadron Collider (6)
- MASS (6)
- Mechanisms (6)
- Monte-Carlo (6)
- N-heterocyclic carbenes (6)
- NAFLD (6)
- NLO Computations (6)
- PD-L1 (6)
- Prevalence (6)
- Schizophrenie (6)
- South Africa (6)
- TRAIL (6)
- UAV (6)
- absorption (6)
- adhesion (6)
- adults (6)
- aggregation (6)
- algorithm (6)
- animal behaviour (6)
- antibiotic resistance (6)
- antidepressant (6)
- arabidopsis thaliana (6)
- astrocytoma (6)
- bacterial pathogens (6)
- basal ganglia (6)
- behavioral conditioning (6)
- bioinformatics (6)
- bone marrow (6)
- boronate esters (6)
- brain development (6)
- brain-computer interface (6)
- cancer therapy (6)
- carcinoma (6)
- cardiac surgery (6)
- cardiovascular diseases (6)
- catalysis (6)
- cell proliferation (6)
- ceramide (6)
- cerebellum (6)
- change detection (6)
- chemokines (6)
- circular dichroism (6)
- cognitive impairment (6)
- communication (6)
- computed tomography (6)
- copper (6)
- coronary artery disease (6)
- cytokinins (6)
- deadwood (6)
- dementia (6)
- design (6)
- down regulation (6)
- drosophila melanogaster (6)
- drug (6)
- drug delivery (6)
- dystonia (6)
- eHealth (6)
- evaluation (6)
- exposure (6)
- extinction (6)
- eye movements (6)
- eyes (6)
- factor XII (6)
- family (6)
- gephyrin (6)
- glaucoma (6)
- glioma (6)
- glucocorticoid receptor (6)
- homogeneous catalysis (6)
- hyaluronic acid (6)
- hymenoptera (6)
- hyperexpression techniques (6)
- ideomotor theory (6)
- immunity (6)
- immunosuppression (6)
- influenza (6)
- injury (6)
- innate immunity (6)
- insulin (6)
- kidneys (6)
- lesions (6)
- leukemia (6)
- liver (6)
- locomotion (6)
- lung (6)
- malaria (6)
- mechanical thrombectomy (6)
- membrane potential (6)
- meningococcal disease (6)
- meta-analysis (6)
- metapopulation (6)
- methylation (6)
- microbiology (6)
- molecular dynamics (6)
- monitoring (6)
- motivation (6)
- mushroom bodies (6)
- myelin (6)
- near-infrared spectroscopy (6)
- neuromuscular junction (6)
- organic chemistry (6)
- outcomes (6)
- p53 (6)
- pathogenesis (6)
- pediatric (6)
- pediatrics (6)
- personalized medicine (6)
- pharmacokinetics (6)
- phylogenetic trees (6)
- plasmodium falciparum (6)
- precision medicine (6)
- presence (6)
- primary care (6)
- psoriasis (6)
- quantum dots (6)
- radiation (6)
- radicals (6)
- receptors (6)
- recombination (6)
- repair (6)
- sRNA (6)
- secondary prevention (6)
- secretion (6)
- segmentation (6)
- sequence alignment (6)
- sleep (6)
- small interfering RNAs (6)
- smoking (6)
- social cognition (6)
- social interaction (6)
- software (6)
- staphylococcus aureus (6)
- states (6)
- susceptibility (6)
- target (6)
- therapeutic drug monitoring (6)
- thermodynamics (6)
- tool (6)
- translational research (6)
- vaccinia virus (6)
- variability (6)
- 53BP1 (5)
- Akt (5)
- BRCA1 (5)
- Biology (5)
- Breaking (5)
- Burkina Faso (5)
- CD95 (5)
- CML (5)
- CMV (5)
- CSF (5)
- CT (5)
- Chlamydia trachomatis (5)
- Durchblutung (5)
- Energy (5)
- Enzyme replacement therapy (5)
- Gene-expression (5)
- Genotoxicity (5)
- Heart failure (5)
- Higgs bosons (5)
- IL-10 (5)
- Immunotherapy (5)
- In-vivo (5)
- MRSA (5)
- MSC (5)
- Magnetic resonance imaging (5)
- Metapopulation (5)
- Multiple myeloma (5)
- Multiple sclerosis (5)
- NF-KAPPA-B (5)
- NFATc1 (5)
- NFκB (5)
- NLO computations (5)
- NLRP3 (5)
- NMR (5)
- NRF2 (5)
- PCR (5)
- PD-1 (5)
- Quality of life (5)
- RNA sequencing (5)
- RNA-binding proteins (5)
- Radiotherapy (5)
- Rat (5)
- T cell (5)
- T lymphocytes (5)
- TNF-α (5)
- TNFR2 (5)
- TerraSAR-X (5)
- Top physics (5)
- Top quark (5)
- VEGF (5)
- actinomycetes (5)
- acute myeloid leukemia (5)
- adaptation (5)
- allergy (5)
- allogeneic stem cell transplantation (5)
- altitudinal gradient (5)
- anatomy (5)
- annotation (5)
- antennal lobe (5)
- antibody (5)
- antigen (5)
- antimicrobial stewardship (5)
- antimicrobials (5)
- aorta (5)
- balance (5)
- bariatric surgery (5)
- biocompatibility (5)
- biological locomotion (5)
- blood brain barrier (5)
- body weight (5)
- bone mineral density (5)
- bone regeneration (5)
- brain tumor (5)
- bronchopulmonary dysplasia (5)
- caloric restriction (5)
- carbenes (5)
- cardiovascular events (5)
- cell cultures (5)
- cell cycle and cell division (5)
- cell differentiation (5)
- cell wall (5)
- ceramides (5)
- cerebral ischemia (5)
- circadian rhythm (5)
- co-culture (5)
- coagulation (5)
- cognition (5)
- cognitive decline (5)
- collagens (5)
- comparison (5)
- competition (5)
- complexes (5)
- condensed matter physics (5)
- coping (5)
- critical illness (5)
- cuticular hydrocarbons (5)
- damage (5)
- density functional theory (5)
- dental education (5)
- detoxification (5)
- diagnostics (5)
- drug design (5)
- drug discovery (5)
- dyes (5)
- ecological momentary assessment (5)
- electron microscopy (5)
- electronic structure (5)
- emission (5)
- endocytosis (5)
- enzyme-linked immunoassays (5)
- experimental design (5)
- eye tracking (5)
- facial expression (5)
- fluorine (5)
- food-cues (5)
- forensic neuropathology (5)
- fungal infection (5)
- gait (5)
- galactomannan (5)
- gastrointestinal tract (5)
- gender (5)
- gene-expression (5)
- generation (5)
- genotoxicity (5)
- glaucoma surgery (5)
- global warming (5)
- glycoprotein VI (5)
- grazing (5)
- guideline adherence (5)
- health-related quality of life (5)
- hearing loss (5)
- heterochromatin (5)
- heterocycles (5)
- human-computer interaction (5)
- immune cells (5)
- implementation (5)
- incidence (5)
- inflammasome (5)
- inflammatory bowel disease (5)
- iron (5)
- larvae (5)
- leaf-cutting ants (5)
- lipids (5)
- localization (5)
- long-term outcome (5)
- mapping (5)
- masked priming (5)
- mast cells (5)
- membrane (5)
- meningitis (5)
- mental disorders (5)
- methionine (5)
- middle cerebral artery occlusion (5)
- migrants (5)
- mineralization (5)
- models (5)
- molecular medicine (5)
- motor control (5)
- movement disorders (5)
- movement ecology (5)
- mutualism (5)
- neuroanatomy (5)
- neurogenesis (5)
- neuronal differentiation (5)
- neuropathy (5)
- norepinephrine (5)
- nuclear envelope (5)
- object detection (5)
- octopamine (5)
- oilseed rape (5)
- oncolysis (5)
- optical spectroscopy (5)
- organization (5)
- paraganglioma (5)
- parasitic diseases (5)
- perception and action (5)
- permeability (5)
- phenology (5)
- pheochromocytoma (5)
- plant-insect interactions (5)
- plants (5)
- polyomavirus (5)
- preclinical research (5)
- protein domains (5)
- protein kinase (5)
- pulmonary hypertension (5)
- quantification (5)
- radial (5)
- recombinant proteins (5)
- recovery (5)
- recruitment (5)
- refractory (5)
- regenerative medicine (5)
- regression analysis (5)
- replacement (5)
- reward (5)
- salt stress (5)
- scale (5)
- secondary structure (5)
- selection (5)
- sequence (5)
- signaling pathway (5)
- single-crystal X-ray study (5)
- skeletal muscle (5)
- small RNA (5)
- social anxiety (5)
- solar cells (5)
- somatic mutations (5)
- spinal cord (5)
- stem-cell transplantation (5)
- structural biology (5)
- structure (5)
- superconductivity (5)
- supramolecular chemistry (5)
- survey (5)
- sympathetic nervous system (5)
- synaptic vesicles (5)
- system (5)
- systems biology (5)
- taxonomy (5)
- thrombo-inflammation (5)
- tomography (5)
- trabeculectomy (5)
- training (5)
- transcriptional regulation (5)
- transverse momentum (5)
- tremor (5)
- vaccination (5)
- vaccine (5)
- valence (5)
- vancomycin (5)
- variants (5)
- vestibular schwannoma (5)
- winter wheat (5)
- working memory (5)
- 3D tissue model (4)
- AI (4)
- AdS-CFT Correspondence (4)
- Adenylate cyclase (4)
- Adult (4)
- Alzheimers disease (4)
- Anaphylaxis (4)
- Anura (4)
- Asthma (4)
- Atlas detector (4)
- B cell (4)
- B-cell lymphoma (4)
- BRAF (4)
- Bordetella pertussis (4)
- Boson (4)
- Botanik (4)
- Brain (4)
- C-MYC (4)
- C-reactive protein (4)
- CNS (4)
- CRISPR/Cas9 (4)
- CT angiography (4)
- Cancer genetics (4)
- Candida auris (4)
- Children (4)
- China (4)
- Cushing’s syndrome (4)
- DNA transcription (4)
- DNA-binding proteins (4)
- Dendritische Zelle (4)
- Diagnosis (4)
- Distributions (4)
- EGFR (4)
- EMG (4)
- ERP (4)
- Earth Observation (4)
- Electroweak interaction (4)
- FDG (4)
- FGFR (4)
- Fn14 (4)
- G proteins (4)
- GABA (4)
- GFAP (4)
- GVHD (4)
- Gene (4)
- Geschichte (4)
- Glioblastoma (4)
- Hierarchy (4)
- Hypothalamus (4)
- IL-2 (4)
- IL-4 (4)
- ITS2 (4)
- Immunobiologie (4)
- InSAR (4)
- IoT (4)
- Krebs (4)
- LPS (4)
- Lepidoptera (4)
- Models (4)
- NASH (4)
- NET (4)
- NGS (4)
- NPY (4)
- NSCLC (4)
- Neurons (4)
- Neurospora crassa (4)
- Parkinson disease (4)
- Pathway (4)
- Pflanzenfressende Insekten (4)
- Pharmakologie (4)
- Protein (4)
- Quantitative anatomy (4)
- RCT (4)
- RNA interference (4)
- ROS (4)
- RapidEye (4)
- Rituximab (4)
- Roux-en-Y gastric bypass surgery (4)
- SSTR (4)
- Salmonella (4)
- Surgery (4)
- TLR4 (4)
- TNF receptor superfamily (4)
- TWEAK (4)
- Th17 (4)
- Transport (4)
- Treatment (4)
- UV/Vis spectroscopy (4)
- Ureaplasma parvum (4)
- Zoologie (4)
- accumulation (4)
- accuracy (4)
- acid sphingomyelinase (4)
- action (4)
- adalimumab (4)
- adenosine (4)
- adipose tissue (4)
- adsorption (4)
- age-related macular degeneration (4)
- agency (4)
- aggression (4)
- algorithms (4)
- alignment (4)
- alkaloids (4)
- amyotrophic-lateral-sclerosis (4)
- animals (4)
- anorexia nervosa (4)
- antagonists (4)
- anticoagulation (4)
- antidepressants (4)
- antifungals (4)
- antiretroviral therapy (4)
- antisense RNA (4)
- anxiety disorders (4)
- apis mellifera (4)
- arousal (4)
- arrhythmia (4)
- arthritis (4)
- aspergillosis (4)
- aspergillus fumigatus (4)
- athletes (4)
- atopic dermatitis (4)
- attention-deficit/hyperactivity disorder (ADHD) (4)
- augmented reality (4)
- automation (4)
- autonomic nervous system (4)
- bevacizumab (4)
- binding analysis (4)
- biodiversity conservation (4)
- biofilms (4)
- bioink (4)
- biokinetics (4)
- biomass (4)
- biomaterials (4)
- biophysics (4)
- bismuth (4)
- blood plasma (4)
- body composition (4)
- bone-mineral density (4)
- brain computer interface (4)
- burden (4)
- cGMP (4)
- calcium phosphate (4)
- cancer metabolism (4)
- cancer patients (4)
- cancer stem cells (4)
- capsaicin (4)
- carcinomas (4)
- cardiac hypertrophy (4)
- cardiorespiratory fitness (4)
- cardiovascular genetics (4)
- cardiovascular risk factors (4)
- care (4)
- catecholamines (4)
- cell-cycle arrest (4)
- cervical dystonia (4)
- chirality (4)
- chlamydia (4)
- chondrocytes (4)
- chondrogenic differentiation (4)
- ciliary neurotrophic factor (4)
- cisplatin (4)
- classical conditioning (4)
- climate (4)
- clinical trials (4)
- cochlear implant (4)
- cognitive control (4)
- colony-stimulating factor (4)
- consortium (4)
- coronary heart disease (4)
- critical care (4)
- cross-coupling (4)
- crowdsensing (4)
- cystic fibrosis (4)
- cytokine (4)
- cytokinesis (4)
- deficiency (4)
- degradation (4)
- dehydrocoupling (4)
- democracy (4)
- demyelination (4)
- dentate gyrus (4)
- dermatology (4)
- dexamethasone (4)
- diagnostic markers (4)
- dialysis (4)
- diborynes (4)
- diffusion (4)
- disability (4)
- disease severity (4)
- dispersal (4)
- eating disorders (4)
- economic growth (4)
- ecosystem function (4)
- editorial (4)
- ejection fraction (4)
- elderly (4)
- electrospinning (4)
- empathy (4)
- endoscopy (4)
- endurance training (4)
- energy metabolism (4)
- enzyme (4)
- enzymes (4)
- epithelial-mesenchymal transition (4)
- ethanol (4)
- excitons (4)
- experience (4)
- experimental stroke (4)
- fNIRS (4)
- facial expressions (4)
- fatty acids (4)
- ferroptosis (4)
- fluorescence imaging (4)
- fluorescence resonance energy transfer (4)
- fluoroarene (4)
- follow up (4)
- food security (4)
- forensic neurotraumatology (4)
- fullerenes (4)
- functional characterization (4)
- functional diversity (4)
- functional magnetic resonance imaging (4)
- fungal structure (4)
- genetic loci (4)
- genome annotation (4)
- genotype (4)
- geography (4)
- geomorphology (4)
- giant cell arteritis (4)
- glucocorticoids (4)
- glucose transporter (4)
- glycolysis (4)
- gynecology (4)
- habitats (4)
- head (4)
- healthy volunteers (4)
- hematology (4)
- hematopoietic stem cells (4)
- hepatitis C virus (4)
- homeostasis (4)
- homologous recombination (4)
- honeybees (4)
- hospitalization (4)
- host cells (4)
- host-pathogen interaction (4)
- hybrid materials (4)
- hydroboration (4)
- hydrogen bonding (4)
- hypercortisolism (4)
- hyperekplexia (4)
- image processing (4)
- imaging techniques (4)
- immune checkpoint blockade (4)
- immune system (4)
- immunization (4)
- immunohistochemistry techniques (4)
- impulsivity (4)
- in vitro selection (4)
- individual-based model (4)
- induction (4)
- infectious diseases (4)
- inpatient rehabilitation (4)
- insect brain (4)
- insulin resistance (4)
- integrins (4)
- interaction (4)
- intervention (4)
- invasion (4)
- invasive aspergillosis (4)
- iron oxide nanoparticles (4)
- jet energy resolution (4)
- juvenile idiopathic arthritis (4)
- knee (4)
- knockout (4)
- knockout mice (4)
- land cover (4)
- latency (4)
- learning and memory (4)
- lines (4)
- linkage (4)
- lipid bilayer (4)
- living cells (4)
- locus coeruleus (4)
- lysosome (4)
- magnesium phosphate cement (4)
- man-computer interface (4)
- marine sponges (4)
- matrix metalloproteinases (4)
- medaka (4)
- medical education (4)
- medical research (4)
- megakaryocytes (4)
- melatonin (4)
- meningioma (4)
- metabarcoding (4)
- methylphenidate (4)
- microRNAs (4)
- microarray (4)
- microglomeruli (4)
- micronuclei (4)
- mindfulness (4)
- minimally invasive surgery (4)
- mitosis (4)
- mobility (4)
- modulation (4)
- molecular modelling (4)
- molecular neuroscience (4)
- monoclonal antibodies (4)
- multisensory processing (4)
- mycotoxin (4)
- myelination (4)
- nanostructures (4)
- natural disturbance (4)
- natural products (4)
- neisseria meningitidis (4)
- neural stem cells (4)
- neuroimaging (4)
- neuroimmunology (4)
- neuropeptides (4)
- neuropsychiatric disorders (4)
- neurotrophins (4)
- nickel (4)
- norepinephrine transporter (4)
- nutrients (4)
- oligodendrocytes (4)
- oncogenes (4)
- opioids (4)
- organoid (4)
- oxidation (4)
- pathogenicity (4)
- pathways (4)
- patient (4)
- patient blood management (4)
- perioperative management (4)
- periprosthetic infection (4)
- persistence (4)
- personality (4)
- perylene bisimide (4)
- phosphorescence (4)
- photoelectron spectroscopy (4)
- phylogeny (4)
- physiology (4)
- phytic acid (4)
- plasma cells (4)
- plasma membrane (4)
- polarization (4)
- polycaprolactone (4)
- polygenic risk score (4)
- polymerase chain reaction (4)
- polyneuropathy (4)
- post-traumatic stress disorder (4)
- principal component analysis (4)
- prognostic marker (4)
- prospective (4)
- protein binding (4)
- protein expression (4)
- protein synthesis (4)
- psychiatry (4)
- quantum dot (4)
- radar (4)
- radical (4)
- radioiodine therapy (4)
- reaction time (4)
- rectal cancer (4)
- regeneration (4)
- renal function (4)
- resilience (4)
- resolution (4)
- response inhibition (4)
- revision (4)
- risk assessment (4)
- risk factor (4)
- saccades (4)
- saproxylic beetles (4)
- sarcopenia (4)
- scaffold (4)
- screening (4)
- seasonality (4)
- sequence motif analysis (4)
- serotonin transporter (4)
- sex (4)
- sex chromosomes (4)
- shear stress (4)
- silver (4)
- singlet oxygen (4)
- skin (4)
- skin punch biopsy (4)
- small fiber neuropathy (4)
- smartwatch (4)
- social systems (4)
- sodium (4)
- solubility (4)
- somatostatin receptor (4)
- spacer (4)
- sphingomyelinase (4)
- sponges (4)
- stability (4)
- startle reflex (4)
- stem cell transplantation (4)
- streptomyces (4)
- stromal cells (4)
- subarachnoid hemorrhage (4)
- substantia nigra (4)
- sulfur (4)
- supersymmetry (4)
- surface water (4)
- surfactants (4)
- surgical and invasive medical procedures (4)
- surgical oncology (4)
- surveillance (4)
- systemic sclerosis (4)
- systems (4)
- targeted therapy (4)
- teeth (4)
- thrombin (4)
- tight junction (4)
- time series analysis (4)
- titanium (4)
- toe (4)
- tolerance (4)
- top quark mass (4)
- total knee replacement (4)
- transient ischemic attack (4)
- translocation (4)
- transport (4)
- transposable elements (4)
- triarylborane (4)
- tryptophan (4)
- two-dimensional materials (4)
- ubiquitination (4)
- uveal melanoma (4)
- viral infection (4)
- viruses (4)
- visual system (4)
- visualization (4)
- vitamin C (4)
- zinc oxide nanoparticles (4)
- γ-H2AX (4)
- 1 (3)
- 18F-FDG (3)
- 18F-FDG PET/CT (3)
- 3D reconstruction (3)
- 5-HT1A (3)
- 5-HT2C (3)
- 5-Methylcytosine (3)
- ACTH (3)
- AIDS (3)
- ARIA (3)
- AVHRR (3)
- Acyrthosiphon pisum (3)
- Alzheimer disease (3)
- Ameisen (3)
- Amphibian oocytes (3)
- Antarctica (3)
- Anxiety (3)
- Autonomous UAV (3)
- B-cells (3)
- B7-H1 (3)
- BCI (3)
- BRAF mutation (3)
- Barth syndrome (3)
- Bevacizumab (3)
- Biomarker (3)
- Biomarkers (3)
- Biomedical engineering (3)
- Bipolar disorder (3)
- Bosons (3)
- C5aR1 (3)
- CD4(+) (3)
- CD40 (3)
- CMR (3)
- COPD (3)
- COVID-19 pandemic (3)
- COVID‐19 (3)
- CRMO (3)
- Caenorhabditis elegans (3)
- Carcinogenesis (3)
- Carcinogenicity (3)
- Central nervous system (3)
- Cerebellar cortex (3)
- Chemotherapy (3)
- Chlamydia (3)
- Coexpression (3)
- Coleoptera (3)
- Cystic fibrosis (3)
- DNA double-strand breaks (3)
- DNA replication (3)
- Deep learning (3)
- Design (3)
- Diabetes mellitus (3)
- EBV (3)
- ERK1/2 (3)
- ESS (3)
- Ecology (3)
- Electron microscopy (3)
- Enterobacteriaceae (3)
- Enzyme induction (3)
- Enzymes (3)
- Epichloë (3)
- Events (3)
- FMRI (3)
- Fabry-associated pain (3)
- Fitness (3)
- Fluorescence (3)
- Formicidae (3)
- GPCR (3)
- GWAS (3)
- Gauge-gravity correspondence (3)
- Gaussian approximation (3)
- Genetik (3)
- Genome (3)
- Gibbs free energy of binding (3)
- HBMEC (3)
- HUWE1 (3)
- Hadron Colliders (3)
- Helicobacter pylori (3)
- Hfq (3)
- Hirschsprung disease (3)
- Hodgkin lymphoma (3)
- Humans (3)
- Hymenoptera (3)
- IGRT (3)
- IgE (3)
- In-vitro (3)
- Insulin (3)
- Kenyon cells (3)
- Käfer (3)
- LC-HRESIMS (3)
- LC/MS (3)
- Langerhans cells (3)
- Legionella pneumophila (3)
- Leishmania (3)
- Lewis acids (3)
- LiDAR (3)
- Listeria monocytogenes (3)
- Lolium perenne (3)
- Lung cancer (3)
- Lymphozyt (3)
- MC simulation (3)
- MDD (3)
- MIZ1 (3)
- MSCs (3)
- MYCN (3)
- Macaranga (3)
- Macrophage (3)
- Mathematik (3)
- Maus (3)
- Measuring Masses (3)
- Meningitis (3)
- Methylation (3)
- Micronuclei (3)
- Mortality (3)
- Muscarinic receptor subtypes (3)
- Muscarinic receptors (3)
- Mycobacterium tuberculosis (3)
- Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) (3)
- N170 (3)
- NMR spectroscopy (3)
- NSG (3)
- NSSI (3)
- Neurodegeneration (3)
- Neuromyelitis optica spectrum disorders (NMOSD) (3)
- Neurotrophic factors (3)
- Nrf2 (3)
- Nude-mice (3)
- Oncology (3)
- Onkogen (3)
- Optic neuritis (3)
- Osteoarthritis (3)
- Outcome survey (3)
- Oxygen (3)
- P-glycoprotein (3)
- PER (3)
- PTEN (3)
- Pair Production (3)
- Parkinsons disease (3)
- Particle data analysis (3)
- Physical activity (3)
- Plants (3)
- PolSAR (3)
- Polymerase chain reaction (3)
- Promoter (3)
- Prostaglandine (3)
- Protein-Tyrosin-Kinasen (3)
- Proton-Proton Collisions (3)
- Psychiatrie (3)
- QCD (3)
- Quadrocopter (3)
- Quadrotor (3)
- RADS (3)
- RNA modification (3)
- RNA polymerase II (3)
- RNA splicing (3)
- RNA structure (3)
- RNA-SEQ (3)
- RNA-Seq (3)
- RNA-sequencing (3)
- RNAseq (3)
- RNS (3)
- Radarsat-2 (3)
- Radiosurgery (3)
- Regulatory T cells (3)
- Relapse (3)
- SGLT1 (3)
- SM background (3)
- SOAT1 (3)
- SWOT (3)
- Saccharomyces cerevisiae (3)
- Salmonella enterica (3)
- Salmonella typhimurium (3)
- Scattering (3)
- Schizophrenia (3)
- Schlaganfall (3)
- Search (3)
- Serotonin (3)
- Skin (3)
- Stem cells (3)
- Strahlentherapie (3)
- Streptomyces (3)
- Stroke (3)
- Supersymmetric models (3)
- Symmetry (3)
- T cell receptor (3)
- T cell receptors (3)
- T-lymphocytes (3)
- TEM (3)
- TGF-beta (3)
- TNF-alpha (3)
- TNFR1 (3)
- TRAF2 (3)
- TRH (3)
- Tourette syndrome (3)
- Tumor-necrosis-factor (3)
- USP28 (3)
- Ureaplasma urealyticum (3)
- VMAT (3)
- Vaccination (3)
- W boson (3)
- Weak (3)
- Wilms tumor (3)
- Wilms' tumor (3)
- X-ray (3)
- Z boson (3)
- Zebrafish (3)
- ab initio calculations (3)
- abandonment (3)
- abnormalities (3)
- absolute configuration (3)
- accelerometer (3)
- acetylcholine (3)
- acrophobia (3)
- actins (3)
- active galactic nuclei (3)
- acute respiratory distress syndrome (3)
- adaption (3)
- adaptive immunity (3)
- adenocarcinoma of the lung (3)
- adipose-derived stromal cells (3)
- adrenal insufficiency (3)
- adrenocortical cancer (3)
- adverse events (3)
- aerobic fitness (3)
- african trypanosomes (3)
- age groups (3)
- ageing (3)
- alcohol (3)
- aldosterone (3)
- alkaline phosphatase (3)
- alternative splicing (3)
- altitudinal gradients (3)
- amino acid (3)
- amyloidosis (3)
- anaemia (3)
- anastomotic leakage (3)
- anemia (3)
- aneurysm (3)
- angiography (3)
- animal sociality (3)
- ankle (3)
- antagonist (3)
- anticipation (3)
- anticoagulants (3)
- antigen testing (3)
- antigenic variation (3)
- antimicrobial (3)
- antimicrobial peptides (3)
- applied physics (3)
- approach (3)
- architecture (3)
- arctic (3)
- arrhythmogenic cardiomyopathy (3)
- arthrography (3)
- arthropods (3)
- artificial photosynthesis (3)
- assistive technology (3)
- attention deficit/hyperactivity disorder (3)
- auditory (3)
- auditory pathway (3)
- autism (3)
- autoantibody (3)
- autoimmune disease (3)
- auxin (3)
- avatars (3)
- axons (3)
- azobenzenes (3)
- bacillus subtilis (3)
- back pain (3)
- bacterial infection (3)
- bacterial meningitis (3)
- bee (3)
- bee decline (3)
- beta-D-glucan (3)
- binding protein (3)
- bioactivity (3)
- biogenic amines (3)
- biological models (3)
- biomedical engineering (3)
- biomedical materials (3)
- bioreactor (3)
- biosensors (3)
- birds (3)
- birth cohort (3)
- black holes (3)
- bladder cancer (3)
- blood vessel (3)
- bone cement (3)
- bone disease (3)
- bone morphogenetic proteins (3)
- bone-marrow (3)
- boronate (3)
- brain cancer (3)
- breast-tumors (3)
- bumblebees (3)
- butterflies (3)
- c-Fos (3)
- c-Myc (3)
- cAMP (3)
- calcification (3)
- calcium phosphate cement (3)
- cancer cells (3)
- canine cancer therapy (3)
- canola (3)
- carbene ligands (3)
- carbohydrates (3)
- cardiac (3)
- cardiac magnetic resonance imaging (3)
- cardiolipin (3)
- cardiomyocytes (3)
- cardiovascular magnetic resonance (3)
- cartilage regeneration (3)
- caspase-3 (3)
- cationic species (3)
- cations (3)
- cell binding (3)
- cell fusion (3)
- cell imaging (3)
- cell migration (3)
- central-nervous-system (3)
- cerebellar tDCS (3)
- cerebrovascular disorders (3)
- charge transfer (3)
- chlamydia infection (3)
- chlamydia trachomatis (3)
- chondrogenesis (3)
- chromophore (3)
- chronic pain (3)
- chronic stress (3)
- citrus (3)
- click chemistry (3)
- clinical practice (3)
- clinical study (3)
- cloning (3)
- closed head injury (3)
- cochlea (3)
- cochlear implantation (3)
- cohort studies (3)
- collagen (3)
- colonoscopy (3)
- combination therapy (3)
- comet assay (3)
- community (3)
- complications (3)
- computational chemistry (3)
- conditioned response (3)
- consciousness (3)
- conversion (3)
- convolutional neural networks (3)
- copy number variation (3)
- coronavirus (3)
- corticosteroids (3)
- count time series (3)
- criteria (3)
- critically ill (3)
- crosstalk (3)
- cryptochrome (3)
- culture (3)
- cysteine protease (3)
- cytosol (3)
- data acquisition (3)
- deadwood enrichment (3)
- deafness (3)
- death receptors (3)
- decellularization (3)
- defects (3)
- deficient mice (3)
- definition (3)
- degeneration (3)
- density (3)
- derivatives (3)
- desmin (3)
- desmosomes (3)
- detrended fluctuation analysis (3)
- diabetic nephropathy (3)
- diagnostic medicine (3)
- diazepam (3)
- diborane (3)
- dilated cardiomyopathy (3)
- dimerization (3)
- disease progression (3)
- disorder (3)
- diversity gradients (3)
- division of labor (3)
- docking (3)
- dogs (3)
- double-blind (3)
- drug adverse reaction (3)
- drug allergy (3)
- drug hypersensitivity (3)
- drug metabolism (3)
- drug repurposing (3)
- drug resistance (3)
- drug therapy (3)
- drugs (3)
- dyes/pigments (3)
- ecological intensification (3)
- electrical and electronic engineering (3)
- electrocardiography (3)
- electrohydrodynamic (3)
- electrohydrodynamics (3)
- electron (3)
- electron tomography (3)
- electrophysiology (3)
- elevated plus-maze (3)
- embodied cognition (3)
- embryos (3)
- emotional regulation (3)
- emphysema (3)
- end-stage renal disease (3)
- endoradiotherapy (3)
- endothelium (3)
- endovascular (3)
- endurance exercise (3)
- energy transfer (3)
- entropy production (3)
- environment (3)
- environmental health (3)
- epidermis (3)
- essential tremor (3)
- estrogens (3)
- evidence-based medicine (3)
- exciton coupling (3)
- exercise intensity (3)
- exome sequencing (3)
- exosomes (3)
- extracorporeal membrane oxygenation (3)
- face (3)
- face perception (3)
- fatty liver disease (3)
- feeding (3)
- female (3)
- fibrin (3)
- fish (3)
- flowers (3)
- fluorescence spectroscopy (3)
- force (3)
- forest ecology (3)
- formicidae (3)
- frailty (3)
- frontotemporal dementia (3)
- fully convolutional neural networks (3)
- functional training (3)
- fungal pathogens (3)
- fungal rhodopsins (3)
- fusion (3)
- gait initiation (3)
- games (3)
- gametogenesis (3)
- gastroenterology (3)
- gefitinib (3)
- gender differences (3)
- gene therapy (3)
- genetic modifiers (3)
- genetic variation (3)
- genome integrity (3)
- genome sequence (3)
- geoarchaeology (3)
- germinal center (3)
- gingivitis (3)
- glial fibrillary acidic protein (3)
- glomerular filtration rate (3)
- glucose (3)
- glutamate (3)
- growth cone (3)
- guard cell (3)
- hands (3)
- healing (3)
- healthcare (3)
- heat transfer (3)
- hemoglobin (3)
- hemolysin (3)
- hepatitis B virus (3)
- herbivores (3)
- herpesvirus (3)
- high-intensity interval training (3)
- hip (3)
- histone H2AX (3)
- histones (3)
- historical document analysis (3)
- honey bee (3)
- host-pathogen interactions (3)
- human brain (3)
- human immunodeficiency virus (3)
- human learning (3)
- humanized mice (3)
- humidity (3)
- hydrodynamics (3)
- hydrology (3)
- hypertrophic cardiomyopathy (3)
- hypofractionation (3)
- image segmentation (3)
- immunoreactive neurons (3)
- immunosenescence (3)
- impedance spectroscopy (3)
- in vitro model (3)
- incisional hernia (3)
- indication for surgery (3)
- individual differences (3)
- infections (3)
- inflammatory diseases (3)
- information (3)
- innovation (3)
- instrument (3)
- insulin receptor (3)
- integration (3)
- intelligence (3)
- intensity distribution (3)
- intensive care (3)
- intentional binding (3)
- interactome (3)
- interface (3)
- interferon (3)
- interleukin-6 (3)
- interleukins (3)
- interoception (3)
- interview (3)
- intestinal epithelial barrier (3)
- intestine (3)
- invasive pulmonary aspergillosis (3)
- investigators (3)
- involvement (3)
- ion channels (3)
- ionic liquids (3)
- iron deficiency (3)
- irradiation (3)
- jet energy scale uncertainty (3)
- ketogenic diet (3)
- kidney function (3)
- kinase (3)
- kinematics (3)
- knee arthroplasty (3)
- land-use change (3)
- laparoscopic ventral hernia repair (3)
- learning curve (3)
- leaves (3)
- left ventricular hypertrophy (3)
- leishmania major (3)
- leishmaniasis (3)
- lenalidomide (3)
- length of stenosis (3)
- leukemic cells (3)
- leukocytes (3)
- library screening (3)
- life history (3)
- ligand binding (3)
- ligands (3)
- light quark jet (3)
- lipidomics (3)
- liquid crystals (3)
- liraglutide (3)
- lithium (3)
- liver metastasis (3)
- local field potentials (3)
- localization microscopy (3)
- locomotor activity (3)
- loneliness (3)
- low back pain (3)
- lung and intrathoracic tumors (3)
- lung fibrosis (3)
- lung injury (3)
- macrocycles (3)
- macrophage (3)
- magnetic properties and materials (3)
- main group elements (3)
- major depressive disorder (3)
- major histocompatibility complex (3)
- malignancy (3)
- malignant melanoma (3)
- malignant tumors (3)
- marine natural products (3)
- marine sponge (3)
- mastocytosis (3)
- mathematical modelling (3)
- mathematics (3)
- measles (3)
- mechanics (3)
- medical rehabilitation (3)
- melanogaster (3)
- melt electrowriting (MEW) (3)
- memory B cells (3)
- memory formation (3)
- mesencephalic locomotor region (3)
- mesenchymal stromal cells (3)
- mesoscopics (3)
- messenger-RNA (3)
- metabolic adaptation (3)
- metabolic modeling (3)
- methionine restriction (3)
- miRNAs (3)
- microarrays (3)
- microbial rhodopsins (3)
- microbiota (3)
- microvascular endothelial cells (3)
- migraine (3)
- minimally invasive (3)
- mitotane (3)
- mixed methods (3)
- mobile health (3)
- monoclonal antibody (3)
- morbidity (3)
- morphology (3)
- morphometry (3)
- mothers (3)
- motoneurons (3)
- multijet background (3)
- multilocularis (3)
- multiple linear regression (3)
- multiple system atrophy (3)
- multisensory integration (3)
- muscarinic receptor subtypes (3)
- muscle (3)
- muscle strength (3)
- music (3)
- myocarditis (3)
- myofibroblast (3)
- natural history (3)
- natural variation (3)
- nature conservation (3)
- necroptosis (3)
- necrosis-factor-alpha (3)
- negative affect (3)
- nephroblastoma (3)
- nephrotoxicity (3)
- nerve fibers (3)
- network (3)
- network analysis (3)
- networks (3)
- neuroblastoma (3)
- neurodevelopment (3)
- neurofilament light chain (3)
- neurological disorders (3)
- neuromelanin (3)
- neuropathology (3)
- neurotrophic factor (3)
- niche (3)
- non-prompt lepton (3)
- non-verbal communication (3)
- nonsmooth optimization (3)
- noradrenaline (3)
- nucleolus (3)
- nucleotide excision repair (3)
- nucleus (3)
- numerical cognition (3)
- obstructive pulmonary disease (3)
- oncolytic viruses (3)
- ontology (3)
- open abdomen (3)
- opioid receptors (3)
- optimal control (3)
- oral anticancer drugs (3)
- organic light emitting diodes (3)
- organic photodiodes (3)
- organic semiconductors (3)
- oscillation (3)
- osteoblasts (3)
- osteogenesis (3)
- osteogenic differentiation (3)
- outbreak (3)
- output elasticities (3)
- oxygenation (3)
- parasite (3)
- parasitology (3)
- pasture (3)
- patch-clamp (3)
- pathophysiology (3)
- pemphigus (3)
- pemphigus vulgaris (3)
- peptide (3)
- peptide receptor radionuclide therapy (3)
- performance monitoring (3)
- perfusion (3)
- phagocytosis (3)
- pharmacogenetics (3)
- pharmacology (3)
- pharmacotherapy (3)
- phenomenology (3)
- phenotypic plasticity (3)
- phosphoantigen (3)
- photodynamic therapy (3)
- photoinduced electron transfer (3)
- photoluminescence (3)
- photoperiodism (3)
- photophysics (3)
- photothrombotic stroke (3)
- phylogenetic analysis (3)
- phylogenetics (3)
- physical fitness (3)
- plasma (3)
- platinum (3)
- pluripotency (3)
- polarized training (3)
- pollinator (3)
- pollution (3)
- poly(2-oxazine) (3)
- polycycles (3)
- polymerization (3)
- polyphenols (3)
- poor prognosis (3)
- population pharmacokinetics (3)
- positron-emission-tomography (3)
- posture (3)
- potassium (3)
- predictors (3)
- preschool children (3)
- preterm (3)
- preterm birth (3)
- pro-inflammatory cytokines (3)
- process mining (3)
- prognostic value (3)
- prospective study (3)
- prostate-specific membrane antigen (3)
- prostate-specific membrane antigen (PSMA) (3)
- protease inhibitors (3)
- protected areas (3)
- protein kinases (3)
- protein structure (3)
- protein-protein interaction (3)
- psycho-oncology (3)
- psychometrics (3)
- pulmonary embolism (3)
- pulse wave velocity (3)
- punishment (3)
- purification (3)
- quality (3)
- quality control (3)
- quality indicators (3)
- quality of democracy (3)
- quantum mechanics (3)
- quantum optics (3)
- quantum physics (3)
- questionnaire (3)
- radiation therapy (3)
- radical reactions (3)
- radiology (3)
- radiomics (3)
- radionuclide therapy (3)
- radiosensitivity (3)
- randomized controlled-trial (3)
- real-time (3)
- real-time PCR (3)
- receptor tyrosine kinases (3)
- recommendations (3)
- red blood cells (3)
- regulator genes (3)
- renal cell carcinoma (3)
- reoperation (3)
- reporter gene (3)
- research (3)
- response regulator (3)
- retinal pigment epithelium (3)
- rhinitis (3)
- rhodesain (3)
- rhodopsin (3)
- ribosomal RNA (3)
- ribosome (3)
- risk stratification (3)
- robustness (3)
- rotator cuff (3)
- ruthenium (3)
- salvage radiotherapy (3)
- sample (3)
- satellite data (3)
- scanning electron microscopy (3)
- schistosomiasis (3)
- school (3)
- scleroderma (3)
- secondary lung tumors (3)
- self-efficacy (3)
- self-organization (3)
- semantic segmentation (3)
- sense of agency (3)
- sensitivity (3)
- sensory cues (3)
- sensory neurons (3)
- sentinel (3)
- sequence databases (3)
- sequestration (3)
- seroprevalence (3)
- serotonin transporter gene (3)
- sexual selection (3)
- shape (3)
- shock (3)
- signal peptides (3)
- single top quark (3)
- single-molecule biophysics (3)
- sleeping sickness (3)
- social attention (3)
- social media (3)
- specialization (3)
- specificity (3)
- sperm (3)
- spiders (3)
- spillover (3)
- spintronics (3)
- spleen (3)
- startle disease (3)
- statistical data (3)
- stemness (3)
- stenosis (3)
- stereotactic body radiotherapy (3)
- stereotactic irradiation (3)
- stimulation (3)
- stomach (3)
- stomata (3)
- strains (3)
- strategies (3)
- strategy (3)
- substituent (3)
- subtypes (3)
- subunit (3)
- subventricular zone (3)
- sucrose (3)
- sucrose responsiveness (3)
- sudden cardiac death (3)
- super-resolution (3)
- superresolution (3)
- surface (3)
- surgical site infection (3)
- susceptibility loci (3)
- swine (3)
- symptoms (3)
- synapse (3)
- synapses (3)
- synaptic inhibition (3)
- synaptic transmission (3)
- synchrotron radiation (3)
- tMCAO (3)
- teaching (3)
- team sport (3)
- telemedicine (3)
- temozolomide (3)
- temporal binding (3)
- temporal bone (3)
- testosterone (3)
- text comprehension (3)
- thermogenesis (3)
- thermoregulation (3)
- threat (3)
- three-dimensional imaging (3)
- thromboembolism (3)
- thymus (3)
- tissue (3)
- top quark pair (3)
- topography (3)
- total hip arthroplasty (3)
- toxins (3)
- trafficking (3)
- tranexamic acid (3)
- transcranial direct current stimulation (3)
- transcription factor (3)
- transgenic mice (3)
- transient absorption (3)
- transmission electron microscopy (3)
- treatment outcome (3)
- treatment response (3)
- triglycerides (3)
- troponin (3)
- trypanosoma (3)
- tsetse fly (3)
- tumor heterogeneity (3)
- tumor necrosis factor (3)
- tundra (3)
- tyrosine kinase (3)
- ultimatum game (3)
- ultrasound (3)
- ultrastructure (3)
- unconscious processing (3)
- urbanization (3)
- uremic toxins (3)
- urinary tract infections (3)
- user experience (3)
- user-centered design (3)
- validity (3)
- vasculitis (3)
- velocity (3)
- ventilation (3)
- vesicles (3)
- viral load (3)
- viral replication (3)
- virotherapy (3)
- virtual environments (3)
- virus (3)
- visual orientation (3)
- visual perception (3)
- wall shear stress (3)
- weight gain (3)
- weight loss (3)
- well-being (3)
- wild bees (3)
- women (3)
- zinc (3)
- zinc oxide (3)
- "-omics" (2)
- 123I-mIBG (2)
- 123I-metaiodobenzylguanidine (2)
- 177Lu (2)
- 18F-FDS (2)
- 18F-LMI1195 (2)
- 2B (2)
- 3D fluoroscopy (2)
- 3D model generation (2)
- 3D models (2)
- 3D scaffolds (2)
- 4D flow (2)
- 5-Azacytidine (2)
- 5-Fluorouracil (2)
- 5-HT transporter (2)
- 5-HT1A receptor (2)
- 5-HTTLPR (2)
- 5-fluorouracil (2)
- A1 adenosine receptors (2)
- AAA (2)
- ABCG2 (2)
- AKT (2)
- ALCL (2)
- AMADEUS (2)
- AMD (2)
- AML (2)
- AMPK (2)
- ARDS (2)
- ARONJ (2)
- ARPES (2)
- ASC (2)
- ATF4 (2)
- Abwehr (2)
- Achilles (2)
- Acromyrmex fracticornis (2)
- Acute lymphocytic leukaemia (2)
- Acute myeloid leukemia (2)
- Africa (2)
- African Trypanosomes (2)
- Agalsidase beta (2)
- Agent (2)
- Albino rats (2)
- Algorithm (2)
- Allogeneic stem cell transplantation (2)
- Alter Orient (2)
- Ames test (2)
- Amino acids (2)
- Amplification (2)
- Analysis (2)
- Animal models (2)
- Annotation (2)
- Antarctic ice sheet (2)
- Anthropocene (2)
- Anti-k Jet (2)
- Antibody (2)
- Antisense RNA (2)
- Ants (2)
- Arabidopsis (2)
- Araneae (2)
- Association (2)
- Assyriologie (2)
- Atomic and molecular interactions with photons (2)
- Ausbreitung (2)
- Autism spectrum disorders (2)
- Autoantibodies (2)
- Autoimmunity (2)
- Autologous hematopoietic stem cell transplantation (2)
- Autoradiography (2)
- Axon degeneration (2)
- Axonal degeneration (2)
- B cell receptors (2)
- B chromosomes (2)
- B lymphocytes (2)
- BBCH (2)
- BCG (2)
- BCL6 (2)
- BDG (2)
- BGK approximation (2)
- BMP (2)
- BMP-2 (2)
- BN compounds (2)
- BRCA2 (2)
- BRENDA (2)
- BTN3 (2)
- Bacillus (2)
- Bacterial pathogens (2)
- Bavaria (2)
- Bees (2)
- Biene (2)
- Big Five (2)
- Bioinformatik (2)
- Biokinetics (2)
- Blattkäfer (2)
- Blood-brain barrier (2)
- Body weight (2)
- Bone marrow (2)
- Bone marrow transplantation (2)
- Bone morphogenetic protein-2 (2)
- Bone-marrow-transplantation (2)
- Bor (2)
- Brassica napus (2)
- Breast-cancer (2)
- Breast-tumors (2)
- Bruchpilot (2)
- C-X-C motif chemokine receptor 4 (2)
- C. elegans (2)
- C57BL/6 mice (2)
- C5a (2)
- CA19-9 (2)
- CADe (2)
- CAR T cell (2)
- CAR T cells (2)
- CCL4 (2)
- CCR2 (2)
- CD117 (2)
- CD274 (2)
- CD28 (2)
- CD30 (2)
- CD39 (2)
- CD4(+) T-cells (2)
- CD40L (2)
- CD73 (2)
- CD8 (2)
- CD9 (2)
- CNN (2)
- CNO (2)
- CNS cancer (2)
- CNS disease (2)
- CNS disorders (2)
- CNV (2)
- COMT (2)
- CORDEX Africa (2)
- CRC (2)
- CSVD (2)
- CTLA-4 (2)
- CYP2W1 (2)
- Ca\(^{2+}\) signalling (2)
- Caco2 cells (2)
- Calibration (2)
- Cambrian (2)
- Camponotus floridanus (2)
- Campylobacter jejuni (2)
- Cancer treatment (2)
- Carcinogen (2)
- Carcinogens (2)
- Cardiovascular disease (2)
- Cardiovascular diseases (2)
- Cardiovascular risk factors (2)
- Cell therapy (2)
- Cells (2)
- Central Asia (2)
- Cerebellum (2)
- Cerebrospinal fluid (2)
- Chagas disease (2)
- Charcot-Marie-Tooth (2)
- Childhood (2)
- Childhood medulloblastoma (2)
- Chili RNA Aptamer (2)
- Chromatin structure (2)
- Chronic heart failure (2)
- Chronic kidney disease (2)
- Circular dichroism (2)
- Cisplatin (2)
- Cl Lowe limit (2)
- Climate change (2)
- Clinical Neuroradiology (2)
- Clinical trial (2)
- Colombia (2)
- Colonization (2)
- Combination (2)
- Computersimulation (2)
- Concealed Information Test (2)
- Conservation (2)
- Consistent partial least squares (2)
- Constraints (2)
- Costa Rica (2)
- Crohn's disease (2)
- Crohn’s disease (2)
- Cross-section (2)
- Cryo-EM (2)
- Cu(111) (2)
- CubeSat (2)
- Cushing’s disease (2)
- Cyanobacteria (2)
- Cys-loop receptor (2)
- Cytokines (2)
- DAPI staining (2)
- DFT (2)
- DHAP (2)
- DIRA (2)
- DLBCL (2)
- DM-domain gene (2)
- DNA Methylation (2)
- DNA antibodies (2)
- DNA barcoding (2)
- DNA helicase (2)
- DNA storage (2)
- DNA-PK (2)
- DNA-repair (2)
- DNA/RNA sensors (2)
- DNS-Schädigung (2)
- DOTATOC (2)
- DSG2 (2)
- DUB (2)
- DYT1 (2)
- Dark-Matter (2)
- Dendritic cells (2)
- Deoxyribozymes (2)
- Deutschland (2)
- Diagnose (2)
- Diagnostic medicine (2)
- Diethylstilbestrol (2)
- Difenidol (2)
- Differential effects of stressors (2)
- Dionaea muscipula (2)
- Disease (2)
- Diseases (2)
- Dopamine (2)
- Dose response (2)
- Dose-response relationship (2)
- Down syndrome (2)
- Drug development (2)
- Drug resistance (2)
- Duchenne muscular dystrophy (2)
- Dyes (2)
- Dynamics (2)
- E. coli serotype 06 (2)
- ECM (2)
- EDA-NOCV (2)
- EF-1A (2)
- EMT (2)
- EPR spectroscopy (2)
- ERK (2)
- EUROASPIRE (2)
- EW (2)
- EZH2 (2)
- Early-onset (2)
- Echinococcosis (2)
- Egypt (2)
- Eiablage (2)
- Eiparasitismus (2)
- Elderly (2)
- Electropermeabilization (2)
- Emotion regulation (2)
- Emotional processing (2)
- Endosymbiont (2)
- Endothelium (2)
- Entanglement (2)
- Environment (2)
- Epidemiology (2)
- Epitope (2)
- Epitranscriptomics (2)
- Estrogen (2)
- European beech (2)
- Evaluation (2)
- Event-related potential (2)
- Event-related potentials (2)
- Exercise capacity (2)
- Exercise testing (2)
- Expansion microscopy (2)
- Extensions of gauge sector (2)
- F-actin (2)
- F8 fimbriae (2)
- FAAH (2)
- FDG PET/CT (2)
- FDG-PET/CT (2)
- FGF-pathway (2)
- FGFR1 (2)
- FIB-4 (2)
- FISH (2)
- FKBP5 (2)
- FSHD (2)
- FTIR spectroscopy (2)
- Fabry (2)
- Fabry genotype (2)
- Fabry nephropathy (2)
- Fabry phenotype (2)
- Factor receptor (2)
- Fagus sylvatica (2)
- FcγR (2)
- Female (2)
- Festkörperphysik (2)
- Fibroblasts (2)
- Fibromyalgia syndrome (2)
- Fish (2)
- Flow cytometry (2)
- Fluorescence spectroscopy (2)
- Fokker–Planck equation (2)
- Foxp3 (2)
- Frosch (2)
- Fusarium (2)
- Fusion proteins (2)
- G protein-coupled receptors (2)
- G-protein (2)
- G-quadruplexes (2)
- GABAA receptors (2)
- GIS (2)
- GLUT2 (2)
- GLUT3 (2)
- GLV-1H68 (2)
- GM-CSF (2)
- GPVI (2)
- Galeruca tanaceti (2)
- Gamma (2)
- Gedächtnisleistung (2)
- Gen (2)
- Gene cloning (2)
- Gene regulation (2)
- Genes (2)
- Genetics research (2)
- Geographie (2)
- Geologie (2)
- German Hepatitis C-Registry (2)
- German people (2)
- Glatiramer acetate (2)
- Gluino production (2)
- Glutathione (2)
- Golgi (2)
- Grad-seq (2)
- Gram-positive bacteria (2)
- Group B Streptococcus (2)
- Growth (2)
- Grundvorstellung (2)
- Guidelines (2)
- Guillain-Barre-Syndrome (2)
- Guinea-pig uterus (2)
- GvHD (2)
- H-1-NMR spectroscopy (2)
- HBV (2)
- HFQ (2)
- HFpEF (2)
- HGF (2)
- HIV-1 (2)
- HKT transporter (2)
- HPA axis (2)
- HPP (2)
- HPV (2)
- HSC (2)
- HUVEC (2)
- Habichtskraut (2)
- Habitat fragmentation (2)
- Haemophilus influenzae (2)
- Halcyon (2)
- Hamburg (2)
- Healthy subjects (2)
- Heart (2)
- Hemolysin (2)
- Heterocycles (2)
- Hexahydro-sila-difenidol analogues (2)
- Hieracium (2)
- Higgs (2)
- Hill numbers (2)
- Hippo signaling (2)
- Holothuria spinifera (2)
- Hormone (2)
- Hospitalization (2)
- Host-parasite interaction (2)
- Host-parasite interactions (2)
- Hsp90 (2)
- Human behaviour (2)
- Human brain (2)
- Human papillomavirus (2)
- Hypothetical gauge bosons (2)
- I-tasser (2)
- IAPS (2)
- IFN-γ (2)
- IL-17 (2)
- IL-6 (2)
- ILEX (2)
- IMAT (2)
- IMRT (2)
- IN-VIVO (2)
- IR (2)
- IR spectroscopy (2)
- Identification (2)
- IgG (2)
- Image-guidance (2)
- Imaging techniques (2)
- Imatinib (2)
- Immunbiologie (2)
- Immunosuppression (2)
- Impact (2)
- In vitro (2)
- Induced apoptosis (2)
- Infections (2)
- Infectious disease (2)
- Inhibitor (2)
- Insects (2)
- Insekten (2)
- Interleukin-4 (2)
- Interleukin-6 (2)
- Internet of Things (2)
- Invasion (2)
- Iran (2)
- JES uncertainty (2)
- JNK (2)
- Japankärpfling (2)
- Jena Experiment (2)
- Jets (2)
- Josephson junctions (2)
- J‐aggregates (2)
- KDIGO (2)
- KEAP1 (2)
- KIT (2)
- Kaposi sarcoma (2)
- Kenya (2)
- Ketogenic diet (2)
- Ki67 (2)
- Kidney function (2)
- Kilombero (2)
- Kultur (2)
- L-arginine (2)
- L929 (2)
- LC-MS/MS (2)
- LINC complex (2)
- LMHFV (2)
- LPP (2)
- LST (2)
- Lampbrush chromosomes (2)
- Landsat time series (2)
- Langerhans-Inseln (2)
- Larvae (2)
- Latin America (2)
- Lebendgebärende Zahnkarpfen (2)
- Lewis acidity (2)
- Lichtheimia (2)
- Ligand (2)
- Lipofuscin (2)
- Longitudinally extensive transverse myelitis (LETM) (2)
- Lung-cancer (2)
- MAG3 (2)
- MAPK signaling cascades (2)
- MASK (2)
- MATQ-seq (2)
- MC event generator (2)
- MCC950 (2)
- MCPH1 (2)
- MDSC (2)
- ME/CFS (2)
- MEG (2)
- MIBG (2)
- MPFL (2)
- MPI (2)
- MPS1 (2)
- MRI criteria (2)
- Machine learning (2)
- Malaysia (2)
- Malignant hyperthermia (2)
- Malignant melanoma (2)
- Masernvirus (2)
- Matlab (2)
- Mc4r (2)
- Measurement (2)
- Mekong (2)
- Melanom (2)
- Melanoma (2)
- Merkel cell polyomavirus (2)
- Mesenchymal stem cells (2)
- Mesenchymal stem/stromal cells (2)
- Mesenteric circulation (2)
- Met (2)
- Metabolic pathways (2)
- Metabolism (2)
- Metabolomics (2)
- Metastatic breast cancer (2)
- Methotrexate (2)
- Microarray (2)
- Microcirculation (2)
- Microglia (2)
- Microtubules (2)
- Mitochondria (2)
- Molecular biology (2)
- Molecular neuroscience (2)
- Molecules (2)
- Monte Carlo (2)
- Mouse (2)
- Mouse model (2)
- Mouse-brain (2)
- Multiple Myeloma (2)
- Multiple bonds (2)
- Multivariate analysis (2)
- Muscarinic receptor antagonists (2)
- Mushroom bodies (2)
- Mutations (2)
- Mycobacterium (2)
- Myeloma (2)
- N ligands (2)
- N-Myc (2)
- N-formyl peptides (2)
- N-heterocyclic carbene (2)
- NEUROWIND (2)
- NF-Kappa-B (2)
- NF-kappa-B (2)
- NF-κB (2)
- NFAT (2)
- NFkB (2)
- NHC (2)
- NMDAR (2)
- NMOSD (2)
- NOAC (2)
- NONO (2)
- NOTCH (2)
- NRPS (2)
- NVP-BEZ235 (2)
- Nanoparticles (2)
- Nervenzelle (2)
- Netzwerk (2)
- Neural circuits (2)
- Neuronal ceroid lipofuscinosis (2)
- Neuropathy (2)
- Neurophysiologie (2)
- Neuroprotection (2)
- Neutrino Telescope (2)
- New Zealand (2)
- Nfatc1 (2)
- Niger (2)
- Non-coding RNAs (2)
- Nucleolus (2)
- OCD (2)
- Olea (2)
- Omega-3-Fettsäuren (2)
- Oocytes (2)
- Oomyzus galerucivorus (2)
- Optical spectroscopy (2)
- Orthoptera (2)
- Oxidative stress (2)
- P53 (2)
- PALM (2)
- PAPA (2)
- PARK2 (2)
- PDE (2)
- PI3K (2)
- PIP2 (2)
- PML (2)
- PMMA (2)
- PPGL (2)
- PROM (2)
- PSA (2)
- PSMA I&T (2)
- PSMA-RADS (2)
- PTCL (2)
- PTSD (2)
- Paediatric (2)
- Pair production (2)
- Pakistan (2)
- Parasit (2)
- Parkinson (2)
- Parkinsonism (2)
- Pathogens (2)
- Patron Distributions (2)
- Patterns (2)
- Pharmazie (2)
- Phase-II (2)
- Phonologische Bewusstheit (2)
- Phosphorylation (2)
- Photochemistry (2)
- Physiologie (2)
- Placebo (2)
- PlanetScope (2)
- Plasma-membrane (2)
- Plus plus (2)
- Pollen (2)
- Positron emission tomography (2)
- Pp Collision (2)
- Prognose (2)
- Program (2)
- Proliferation (2)
- Prostate Cancer (2)
- Pseudomonas aeruginosa (2)
- Psychiatric disorders (2)
- Pulmonary imaging (2)
- Purkinje cells (2)
- Pädiatrie (2)
- R factor = 0.027 (2)
- RCC (2)
- RFID (2)
- RHO (2)
- RKIP (2)
- RNA extraction (2)
- RNA secondary structure (2)
- RNA synthesis (2)
- RNA-SEQ data (2)
- RNA-dependent RNA polymerase (2)
- RNA-polymerase-II (2)
- RSK (2)
- RT-PCR (2)
- RT-qPCR (2)
- Radiative-corrections (2)
- Radioligand binding (2)
- Radionuclide Therapy (2)
- Raf kinases (2)
- Randomized controlled trial (2)
- Randomized controlled-trial (2)
- Rashba effect (2)
- Rats (2)
- Ratte (2)
- Reaction kinetics and dynamics (2)
- Rectal cancer (2)
- Reduction (2)
- Regression (2)
- Rehabilitation (2)
- Renal cell carcinoma (2)
- Repair (2)
- Reproductive toxicity (2)
- Rezension (2)
- Rhabdomyosarcoma (2)
- Rheumatologie (2)
- Rhizopus (2)
- Rhodobacter sphaeroides (2)
- Risk (2)
- Risk factors (2)
- Ruthenium (2)
- Ruthenium complexes (2)
- Ruxolitinib (2)
- S-ADAPT (2)
- S. aureus (2)
- SAH (2)
- SARS‐CoV‐2 (2)
- SEM (2)
- SEQ (2)
- SF-36 (2)
- SGLT2 inhibitor (2)
- SGLT2 inhibitors (2)
- SHRSP (2)
- SLC2A3 (2)
- SLX4 (2)
- SMAD signaling (2)
- SMN (2)
- SNP (2)
- SOX9 (2)
- SPECT/CT (2)
- STR profile (2)
- SUV (2)
- Salmonella Typhimurium (2)
- Salmonella-containing vacuole (SCV) (2)
- Salmonella/microsome assay (2)
- Salmonellosis (2)
- Scale (2)
- Scarabaeidae (2)
- Schwann cells (2)
- Selective attention (2)
- Sensitivity (2)
- Signal transduction (2)
- Silicones (2)
- Simulation (2)
- Skorpion (2)
- SnRK1 (2)
- Solution-state NMR (2)
- Sonic hedgehog (2)
- Spermatogenesis (2)
- Squalius alburnoides (2)
- Staphylococcus (2)
- Stem cell (2)
- Stereology (2)
- Stereoselectivity (2)
- Stereotactic body radiotherapy (2)
- Stimuli (2)
- Strains (2)
- Streptomyces axinellae (2)
- Stress (2)
- Structural Biology (2)
- Struktur (2)
- Subarachnoid hemorrhage (2)
- Succinylcholine (2)
- Surveillance (2)
- Swine (2)
- Symmetry-breaking (2)
- System (2)
- Systematic review (2)
- Systemic sclerosis (2)
- Systems (2)
- T = 100 K (2)
- T cell activation (2)
- T cell receptor excision circles (2)
- T-cadherin (2)
- T-cell (2)
- T-cell lymphoma (2)
- TAVI (2)
- TB (2)
- TCR signaling cascade (2)
- TGF-BETA (2)
- TGFβ signaling (2)
- TGN1412 (2)
- TIMELINE (2)
- TKA (2)
- TKI (2)
- TLR2 (2)
- TNAP (2)
- TNF superfamily (2)
- TNFα (2)
- TP53 (2)
- TanDEM-X (2)
- Tell Karrana (2)
- Temozolomide (2)
- Theoretische Ökologie (2)
- Thyroid cancer (2)
- Tian Shan (2)
- Time-course (2)
- Tissue (2)
- Tissue engineering (2)
- Top-Quark (2)
- Tranquillizer (2)
- Transcriptome (2)
- Transgenic mice (2)
- Translational research (2)
- Transporter (2)
- Trees (2)
- Tregs (2)
- Tregs (regulatory T cells) (2)
- TrkB (2)
- Tuberculosis (2)
- Tumor Treating Fields (TTFields) (2)
- Uganda (2)
- Ulcerative colitis (2)
- Uzbekistan (2)
- VACV (2)
- VAL66MET polymorphism (2)
- VSOP (2)
- Vaccine (2)
- Vaccinia virus (2)
- Validation (2)
- Variability (2)
- Variants (2)
- Vasodilatator-stimuliertes Phosphoprotein (2)
- Vesicles (2)
- WH2 domain (2)
- WNT (2)
- WSS (2)
- WZ (2)
- West Gondwana (2)
- Western Cape (2)
- Western Europe (2)
- Western diet (2)
- Wilms tumour (2)
- Wirt (2)
- Wnt (2)
- Wnt signalling (2)
- X-ray computed (2)
- XAI (2)
- XR (2)
- Xenopus oocytes (2)
- Y chromosome (2)
- YAP (2)
- Yoga (2)
- YouTube (2)
- Zambia (2)
- Zelldifferenzierung (2)
- [68Ga]PentixaFor (2)
- ablation (2)
- abscisic acid (2)
- abscisic acid (ABA) (2)
- absorption spectra (2)
- abundance (2)
- acceptance (2)
- acceptance time efficiency (2)
- accretion (2)
- acetylsalicylic acid (2)
- acid ceramidase inhibitor ceranib-2 (2)
- acoustic signals (2)
- acoustic startle (2)
- actin cytoskeleton (2)
- action control (2)
- action effects (2)
- action planning (2)
- action potential (2)
- action potentials (2)
- activity (2)
- activity rhythm (2)
- acupuncture (2)
- acute graft-versus-host disease (2)
- acute heart failure (2)
- acute lymphoblastic leukemia (2)
- acute myeloid leukaemia (2)
- adaptive immune system (2)
- addiction (2)
- adenocarcinoma (2)
- adenomas (2)
- adenosine receptors (2)
- adenovirus (2)
- adenylate cyclase toxin (2)
- adhesion molecules (2)
- adipocytes (2)
- adjustment (2)
- adjuvant treatment (2)
- adolescent (2)
- adoptive transfer (2)
- adrenal (2)
- adrenal cancer (2)
- adrenal crisis (2)
- adrenal tumours (2)
- adrenocortical tumors (2)
- adult (2)
- adult-onset (2)
- adulthood (2)
- adverse drug reaction (2)
- adverse effects (2)
- adversity (2)
- affect (2)
- affinity (2)
- age-related hearing loss (2)
- aged 80 and over (2)
- agonist (2)
- agonistic antibodies (2)
- agreement (2)
- agrobacterium tumefaciens (2)
- agroecology (2)
- agroecosystems (2)
- airway management (2)
- albumin (2)
- alleles (2)
- allelic replacement (2)
- allergic rhinitis (2)
- alliance (2)
- allogeneic hematopoietic stem cell transplantation (2)
- allometric scaling (2)
- alloreactive T cells (2)
- allostatic load (2)
- alpaca (2)
- alpha (2)
- alpha-synuclein (2)
- altruism (2)
- altruistic compensation (2)
- alveolar bone loss (2)
- alveolar echinococcosis (2)
- amino acid restriction (2)
- amino acid sequence (2)
- amino acid transporter (2)
- amino acids (2)
- aminotroponiminates (2)
- ampicillin (2)
- amplicon sequencing (2)
- amyotrophic lateral sclerosis (ALS) (2)
- anaesthesiology (2)
- anaesthetics (2)
- analgesia (2)
- anaphylaxis (2)
- anaplastic large cell lymphoma (2)
- anchoring (2)
- androgen deprivation therapy (2)
- anesthetics (2)
- angle-resolved photoemission spectroscopy (2)
- anhedonia (2)
- anion channel (2)
- anions (2)
- annulation (2)
- anomaly detection (2)
- ant (2)
- ant brain (2)
- antenna (2)
- anterior cingulate cortex (2)
- anterior insula (2)
- anthocyanins (2)
- anti-k jet (2)
- anti-parasitic (2)
- anti-trypanosomal (2)
- anti-tumor agents (2)
- antibacterial (2)
- antibiotic (2)
- antibody fusion proteins (2)
- anticancer activity (2)
- antigen presentation (2)
- antigens (2)
- antimicrobial activities (2)
- antimicrobial activity (2)
- antimony (2)
- antioxidant (2)
- antioxidants (2)
- antirheumatic agents (2)
- antisense RNAs (2)
- antiviral treatment (2)
- anxiety-like behavior (2)
- aortic arch (2)
- aphasia (2)
- app (2)
- approach-avoidance (2)
- arabidopsis (2)
- archaea (2)
- areas (2)
- artemisinin (2)
- arteriovenous loop (2)
- ascites (2)
- aspiration (2)
- assay (2)
- assistive devices (2)
- associative learning (2)
- asymmetry (2)
- atmospheric chemistry (2)
- atmospheric circulation (2)
- atomic-force microscopy (2)
- attention capture (2)
- attentional bias (2)
- auditory cortex (2)
- autobiographical memory (2)
- autoimmune (2)
- autoinhibition (2)
- autologous stem cell transplantation (2)
- autologous transplantation (2)
- autonomous (2)
- auxins (2)
- avatar embodiment (2)
- avoidance (2)
- avoidance learning (2)
- awareness (2)
- axonal degeneration (2)
- axonal transport (2)
- azulene (2)
- bZIP (2)
- background knowledge (2)
- bacterial genetics (2)
- bacterial genomics (2)
- bacteriology (2)
- baghdadite (2)
- barbiturates (2)
- bark beetles (2)
- barrier (2)
- base of support (2)
- basic mental models (2)
- bats (2)
- beech forests (2)
- behavioral plasticity (2)
- beta diversity (2)
- beta oscillations (2)
- beta-catenin (2)
- beta-oxidation (2)
- bias correction (2)
- biased signaling (2)
- big five (2)
- bile (2)
- bioconjugation (2)
- biodosimetry (2)
- bioengineering (2)
- biofeedback (2)
- biofilm (2)
- biofilm formation (2)
- biogenesis (2)
- biological sciences (2)
- biological techniques (2)
- biologics (2)
- bioluminescence imaging (2)
- biomechanics (2)
- biomedicine, general (2)
- biopsy (2)
- biosensor (2)
- biradicals (2)
- bisphosphonates (2)
- bisulfite pyrosequencing (2)
- blastocysts (2)
- blazars (2)
- bleeding (2)
- blood coagulation (2)
- blood gas analysis (2)
- blood platelets (2)
- blood-brain barrier (BBB) model (2)
- blood-nerve barrier (2)
- blood-stream forms (2)
- blood–labyrinth barrier (2)
- body ownership (2)
- body representation (2)
- body weight modification (2)
- body weight perception (2)
- bonding (2)
- bone formation (2)
- bone fractures (2)
- bone imaging (2)
- bone loss (2)
- bone marrow edema (2)
- bone marrow immune-microenvironment (2)
- bone marrow stromal cells (2)
- bone metastasis (2)
- bone remodeling (2)
- bone replacement material (2)
- boronateesters (2)
- boronic acid (2)
- bortezomib (2)
- borylene (2)
- borylenes (2)
- brain disorders (2)
- brain edema (2)
- brain endothelial cells (2)
- brain metastases (2)
- brain pathology (2)
- brain potentials (2)
- brain stem (2)
- brain-computer interface (BCI) (2)
- brain-computer interfaces (2)
- breed predisposition (2)
- bridging (2)
- brucei (2)
- bullous pemphigoid (2)
- butyrophilin (2)
- butyrophilin 3 (2)
- butyrylcholinesterase (2)
- c-MYC (2)
- c-myc (2)
- c-reactive protein (2)
- cAArC (2)
- cEND (2)
- caenorhabditis elegans (2)
- caffeine (2)
- cage compounds (2)
- calcium signaling (2)
- calibration (2)
- calipered (2)
- calorie content (2)
- calorimeter (2)
- calprotectin (2)
- cancer detection and diagnosis (2)
- cancer diagnosis (2)
- cancer immunotherapy (2)
- cancer microenvironment (2)
- cancer risk (2)
- cancer risk factors (2)
- cancers and neoplasms (2)
- candidate gene (2)
- candidemia (2)
- canine (2)
- canine cancer cell lines (2)
- canine soft tissue sarcoma (CSTS) (2)
- capacitance (2)
- capillary electrophoresis (2)
- carabid beetles (2)
- carbon (2)
- carbon dioxide (2)
- carbon nanotubes (2)
- carborane (2)
- carboxylation (2)
- carcinogenesis (2)
- cardiac MRI (2)
- cardiac innervation imaging (2)
- cardiac magnetic resonance (2)
- cardiac metabolism (2)
- cardiac nerve (2)
- cardiac output (2)
- cardiac rehabilitation (2)
- cardinality constraints (2)
- cardiology (2)
- cardiovascular (2)
- cardiovascular arousal (2)
- cardiovascular morbidity (2)
- caregiver burden (2)
- caries (2)
- carotid atherosclerosis (2)
- carotid stenosis (2)
- carotid ultrasound (2)
- carpenter ant (2)
- cartilage repair (2)
- caspase-8 (2)
- catalytic (2)
- cathepsin (2)
- causality (2)
- cell adhesion (2)
- cell binding assay (2)
- cell culture (2)
- cell cycle arrest (2)
- cell division (2)
- cell fate (2)
- cell labeling (2)
- cell metabolism (2)
- cell of origin (2)
- cell signalling (2)
- cell surface (2)
- cellular physiology (2)
- cellular signalling networks (2)
- cement (2)
- ceramics (2)
- cerebEND (2)
- cerebral autoregulation (2)
- cerebral blood flow (2)
- cerebrosides (2)
- chalcogens (2)
- change vector analysis (2)
- channel (2)
- channelrhodopsin (2)
- chaperone (2)
- characterization (2)
- checkpoint inhibitors (2)
- chemical bonding (2)
- chemical communication (2)
- chemical ecology (2)
- chemical mimicry (2)
- chemokine (2)
- chemotaxis (2)
- child (2)
- child development (2)
- childhood (2)
- childhood asthma (2)
- childhood cancer (2)
- childhood maltreatment (2)
- chimeric antigen receptor (2)
- chirality transfer (2)
- chloroquine (2)
- cholestasis (2)
- cholesterol (2)
- cholinergic system (2)
- chromatin structure (2)
- chromosomes (2)
- chronic cerebrovascular disease (2)
- chronic hepatitis C (2)
- chronic kidney-disease (2)
- chronic myelogenous leukemia (2)
- chronic myeloid leukemia (2)
- chronic non-bacterial osteomyelitis (2)
- chronic nonbacterial osteomyelitis (2)
- chronic recurrent multifocal osteomyelitis (2)
- chronic thromboembolic pulmonary hypertension (2)
- chronobiology (2)
- chronophin (2)
- chronotype (2)
- cigarette smoking (2)
- circulation patterns (2)
- circulation type (2)
- cirrhosis (2)
- claudin-1 (2)
- clinical (2)
- clinical diagnosis (2)
- clinical outcome (2)
- clinical-practice (2)
- clothing (2)
- cluster analysis (2)
- coastal erosion (2)
- coated vesicles (2)
- coatings (2)
- cochlear nucleus (2)
- coexistence (2)
- cognitive conflict (2)
- cognitive function (2)
- cognitive neuroscience (2)
- cognitive psychology (2)
- cohort study (2)
- cold stress (2)
- colloids (2)
- colon (2)
- colon cancer (2)
- colonization (2)
- colorectal carcinoma (2)
- combined therapy (2)
- common variants (2)
- communities (2)
- community structure (2)
- comorbidity (2)
- comparability (2)
- comparative genomic hybridization (2)
- complement (2)
- complement system (2)
- complementary alternative medicine (2)
- complementary medicine (2)
- complex regional pain syndrome (2)
- complexity (2)
- complication (2)
- components (2)
- compound eye (2)
- compressive strength (2)
- computational biology and bioinformatics (2)
- computational physics (2)
- computer software (2)
- cone beam CT (2)
- conjugation (2)
- connective tissue (2)
- consensus (2)
- conservation biology (2)
- consolidation (2)
- contact-kinin system (2)
- context (2)
- contextual fear conditioning (2)
- contrast (2)
- convection volume (2)
- conversational agents (2)
- convolutional neural network (2)
- cooperation (2)
- coordination polymers (2)
- copeptin (2)
- corannulene (2)
- cord blood (2)
- coronavirus disease 2019 (2)
- correction (2)
- correlates (2)
- correlation (2)
- cortex (2)
- cortical activation (2)
- cortical neurons (2)
- cost-effectiveness (2)
- costs (2)
- coupling strength (2)
- covalent inhibitors (2)
- craving (2)
- creatine kinase (2)
- creatinine (2)
- creativity (2)
- cropping systems (2)
- cross-cultural comparison (2)
- cross-link repair (2)
- cross-sectional studies (2)
- crowdsourcing (2)
- crystal engineering (2)
- crystal-structure (2)
- cultivation (2)
- cultures (2)
- curcumin (2)
- cyanoborate (2)
- cyanoborates (2)
- cybersickness (2)
- cycle (2)
- cyclic (alkyl)(amino)carbenes (2)
- cycling (2)
- cycloaddition (2)
- cyclodextrin (2)
- cyclophanes (2)
- cystic fibrosis patients (2)
- cytochrome P450 3A4 (CYP3A4) (2)
- cytokine production (2)
- cytokine release (2)
- cytokine secretion (2)
- cytosolic pH (2)
- cytotoxic (2)
- cytotoxic activity (2)
- dRNA-Seq (2)
- daratumumab (2)
- dark matter (2)
- data analysis (2)
- data fusion (2)
- data mining (2)
- data visualization (2)
- data warehouse (2)
- ddPCR (2)
- death (2)
- death rates (2)
- decline (2)
- decomposition (2)
- deficit hyperactivity disorder (2)
- deformation (2)
- degree of stenosis (2)
- delineation (2)
- demography (2)
- dendritic cell (2)
- dendrobates pumilio (2)
- dental trauma (2)
- dependent protein-kinase (2)
- dereplication (2)
- derivation (2)
- dermatitis (2)
- desirable difficulties (2)
- desk-based (2)
- desmosome (2)
- developmental dyslexia (2)
- developmental plasticity (2)
- diabetic retinopathy (2)
- dialysis adequacy (2)
- diapause (2)
- diazadiborinines (2)
- diboration (2)
- dictator game (2)
- dieting success (2)
- differential diagnosis (2)
- differential expression (2)
- differentiation potential (2)
- diffuse large B-cell lymphoma (2)
- diffusion tensor imaging (2)
- digital health (2)
- dimensions (2)
- dimethyl fumarate (2)
- diode (2)
- direct anterior approach (2)
- direct gaze (2)
- direct-acting antivirals (2)
- discovery (2)
- discriminant analysis (2)
- discussion report (2)
- diseases (2)
- diseases of the nervous system (2)
- disembodiment (2)
- disorders (2)
- dispersal ability (2)
- dispersal rate (2)
- distance measurement (2)
- distress (2)
- distributed control (2)
- distribution (2)
- dog (2)
- dopaminergics (2)
- dorsal root ganglion (2)
- dorsolateral prefrontal cortex (2)
- double intentionality (2)
- doxorubicin (2)
- drug–drug interactions (DDIs) (2)
- dual function (2)
- dual polarimetry (2)
- dual-energy CT (2)
- dual-stage crosslinking (2)
- duchenne muscular dystrophy (2)
- dunce (2)
- dynamic covalent chemistry (2)
- dynamic programming (2)
- dysfunction (2)
- dysphagia (2)
- dysplasia (2)
- dyspnea (2)
- early diagnosis (2)
- early intervention (2)
- early recognition (2)
- echinococcus multilocularis (2)
- ecosystem service (2)
- edema (2)
- edge states (2)
- editorial board (2)
- education for sustainable healthcare (2)
- effectiveness (2)
- effects (2)
- efficiency (2)
- elbow joint (2)
- electroactive (2)
- electrocatalysis (2)
- electrochemistry (2)
- electroencephalogram (2)
- electroencephalography (EEG) (2)
- electrolytes (2)
- electromyography (2)
- electronic health records (2)
- electrophilic substitution (2)
- electroporation (2)
- element (2)
- elements (2)
- elevation (2)
- elevation gradient (2)
- elongation (2)
- embryo (2)
- embryonic stem cells (2)
- emissions (2)
- emotion recognition (2)
- emotional experience (2)
- emotional facial expressions (2)
- emotional pictures (2)
- empagliflozin (2)
- emulsions (2)
- enantiomers (2)
- encephalitis (2)
- endocannabinoid (2)
- endochondral ossification (2)
- endoglin (2)
- endoluminal (2)
- endophenotype (2)
- endophyte (2)
- endoplasmic reticulum (2)
- endosomes (2)
- endothelial cell (2)
- endothelin-1 (2)
- endotoxemia (2)
- endovascular therapy (2)
- endovascular treatment (2)
- energy homeostasis (2)
- engineering (2)
- enteric nervous system (2)
- enteric pathogens (2)
- enterica serovar typhimurium (2)
- entomology (2)
- entropy (2)
- envelopment (2)
- environmental exposure (2)
- environmental impact (2)
- environmental justice (2)
- environments (2)
- enzyme activation (2)
- enzyme inhibitors (2)
- epidemology (2)
- epidermal growth factor (2)
- epithelium (2)
- epitope mapping (2)
- establishment (2)
- estimation error (2)
- ethics (2)
- etymology (2)
- eudaimonia (2)
- eugenol (2)
- evapotranspiration (2)
- evolutionary biology (2)
- evolutionary genetics (2)
- exact matching (2)
- excimer formation (2)
- excitations (2)
- excited states (2)
- exciton (2)
- exercise intervention (2)
- exhaustion (2)
- expansion microscopy (2)
- experiment (2)
- experimental models of disease (2)
- expertise (2)
- exposure therapy (2)
- expression signature (2)
- extinction risk (2)
- extracellular domain (2)
- extramedullary disease (2)
- face processing (2)
- facial electromyography (2)
- factor H (2)
- factor XI (2)
- factor-I (2)
- failure (2)
- fake lepton (2)
- familial DCM (2)
- families (2)
- fatty liver (2)
- fear generalization (2)
- fear-potentiated startle (2)
- feasibility (2)
- feature selection (2)
- features (2)
- femur (2)
- fermions (2)
- ferromagnetism (2)
- fertility (2)
- fetal programming (2)
- fibers (2)
- fibrinogen (2)
- fibroblast activation protein (2)
- fibromyalgia (2)
- field (2)
- films (2)
- fire (2)
- fish model (2)
- fission yeast (2)
- fitness (2)
- fixation (2)
- flagellar pocket (2)
- flagellum (2)
- flood (2)
- flow (2)
- flowering plants (2)
- fluid (2)
- fluorescence correlation spectroscopy (2)
- fluorescent dyes (2)
- fluorescent probe (2)
- fluorescent protein (2)
- fluorescent proteins (2)
- fluorescent-probes (2)
- fluoroscopy (2)
- flupyradifurone (2)
- flux (2)
- flux balance analysis (2)
- foamy virus (2)
- foamy viruses (2)
- focal cerebral-ischemia (2)
- follicular lymphoma (2)
- food allergy (2)
- food consumption (2)
- food safety (2)
- foot (2)
- forecast (2)
- forest degradation (2)
- forest health (2)
- forests (2)
- formation control (2)
- fpVCT (2)
- fracture healing (2)
- framework (2)
- free choice (2)
- free energy (2)
- frontal cortex (2)
- fruit set (2)
- functional analysis (2)
- functional traits (2)
- functionalization (2)
- fungal infections (2)
- fused deposition modeling (FDM) (2)
- future directions (2)
- gain (2)
- gait analysis (2)
- gambling (2)
- gametocyte (2)
- gamma (2)
- gamma rays (2)
- gas (2)
- gastric bypass (2)
- gastrointestinal infections (2)
- gels (2)
- gemcitabine (2)
- gene cloning (2)
- gene conversion (2)
- gene expression profiling (2)
- gene mutations (2)
- gene targeting (2)
- gene-environment interaction (2)
- general anaesthesia (2)
- general practice (2)
- general relativity (2)
- generalization (2)
- generalized anxiety disorder (2)
- generalized cerebral edema (2)
- generation effect (2)
- genetic diagnostics (2)
- genetic engineering (2)
- genetic polymorphisms (2)
- genetic susceptibility (2)
- genetic testing (2)
- genetic variants (2)
- genetically modified plants (2)
- genome analysis (2)
- genome assembly (2)
- genome sequencing (2)
- genome wide (2)
- genome-wide association study (2)
- genomic analysis (2)
- genomic databases (2)
- genomic imprinting (2)
- genomic libraries (2)
- genotyping (2)
- geometry (2)
- germline mutation (2)
- gestational diabetes mellitus (2)
- giant ventral hernia (2)
- glaciers (2)
- glial fate modulation (2)
- glioblastoma multiforme (GBM) (2)
- globotriaosylceramide (2)
- glucose metabolism (2)
- glutathione (2)
- glycemic control (2)
- glycine (2)
- glycopeptide antibiotics (2)
- glycoprotein Ib (2)
- glycoprotein receptor Ib (2)
- go/no-go task (2)
- gold nanoparticles (2)
- grading (2)
- graft (2)
- graft versus host disease (2)
- gram-negative bacteria (2)
- granules (2)
- granulocytes (2)
- grassland (2)
- grasslands (2)
- green fluorescent protein (2)
- gridle muscular-dystrophy (2)
- growth factor (2)
- growth factor beta (2)
- growth hormone deficiency (2)
- guanylyl cyclase (2)
- guard cells (2)
- guided bone regeneration (2)
- gut bacteria (2)
- gut barrier (2)
- gynogenesis (2)
- gyroscope (2)
- habits (2)
- haemophilus influenzae (2)
- haemostasis (2)
- halogenation (2)
- hand (2)
- haploinsufficiency (2)
- harmonization (2)
- head and neck squamous cell carcinoma (2)
- head-mounted display (2)
- health (2)
- health care (2)
- health care workers (2)
- health economics (2)
- health monitoring (2)
- health policy (2)
- hearing (2)
- hearing impairment (2)
- hearing preservation (2)
- heart failure with mid-range ejection fraction (2)
- heart rate variability (2)
- heat shock response (2)
- heat stress (2)
- helicase (2)
- helicene (2)
- helicenes (2)
- helminths (2)
- hematologic malignancies (2)
- hematopoietic (2)
- hematopoietic stem cell transplantation (2)
- heme oxygenase-1 (2)
- hemicraniectomy (2)
- hemodiafiltration (2)
- hepatic stellate cell (2)
- hepatocellular carcinoma (2)
- herbivore (2)
- herbivory (2)
- hereditary breast and ovarian cancer (2)
- hereditary motor and sensory neuropathy (2)
- heritability (2)
- herpes simplex virus (2)
- herpes virus (2)
- heterogeneity (2)
- heterogeneous catalysis (2)
- heterosis (2)
- hiPSC (2)
- hiPSC-CM (2)
- hierarchy (2)
- high contrast (2)
- high performance liquid chromatography (2)
- high risk (2)
- high-risk prostate cancer (2)
- high-throughput screening (2)
- hip fracture (2)
- hippocampal neurogenesis (2)
- histamine (2)
- histopathology (2)
- history (2)
- holography and condensed matter physics (AdS/CMT) (2)
- homogenous catalysis (2)
- homologous chromosomes (2)
- homology modeling (2)
- hormones (2)
- hospitalizations (2)
- human adipose-derived stromal cells (2)
- human african trypanosomiasis (2)
- human breast (2)
- human cells (2)
- human cytomegalovirus (HCMV) (2)
- human exposure (2)
- human genetics (2)
- human interleukin-4 (2)
- human macrophages (2)
- human pathogenic fungi (2)
- human rights (2)
- human-centered design (2)
- hybridogenesis (2)
- hybridomas (2)
- hydrocortisone (2)
- hydrogel (2)
- hydrogen (2)
- hyperactivity (2)
- hyperalgesia (2)
- hypercholesterolemia (2)
- hyperoxia (2)
- hypersensitivity (2)
- hyphae (2)
- hypogammaglobulinemia (2)
- hypothalamus (2)
- hypotonic (2)
- iPSC-cardiomyocytes (2)
- idiopathic inflammatory myopathies (2)
- ileocecal resection (2)
- illness (2)
- image analysis (2)
- image-guided radiation therapy (2)
- imaging the immune system (2)
- imidazolate (2)
- immediate early genes (2)
- immersive technologies (2)
- immune cell infiltration (2)
- immune escape (2)
- immune reconstitution (2)
- immune suppression (2)
- immune therapy (2)
- immunoassay (2)
- immunoblotting (2)
- immunodeficiency (2)
- immunoglobulin superfamily (2)
- immunostaining (2)
- immunosurveillance (2)
- implant (2)
- implant positioning (2)
- implantation (2)
- implants (2)
- in silico analysis (2)
- in situ hybridization (2)
- in vitro models (2)
- inactivation (2)
- incentives (2)
- individual‐based model (2)
- inebilizumab (2)
- infarction (2)
- infection control (2)
- inferior vena cava (2)
- inflammatory cytokines (2)
- inflammatory neuropathy (2)
- inflammatory response (2)
- influenza A virus (2)
- informal caregiving (2)
- information extraction (2)
- infrared spectroscopy (2)
- inhibitors (2)
- inhibitory neurotransmission (2)
- injury prevention (2)
- innate immune response (2)
- innate immune system (2)
- inner ear (2)
- insect decline (2)
- insect flight (2)
- insect monitoring (2)
- insect vision (2)
- insecticide (2)
- insecticides (2)
- insights (2)
- insulin signaling (2)
- integral (2)
- integrated stress response (2)
- intellectual disability (2)
- intensity zones (2)
- interaction networks (2)
- interacts (2)
- interband cascade lasers (2)
- interferometry (2)
- interleukin 6 (2)
- interleukin-8 (2)
- internal medicine (2)
- internalization (2)
- internet of things (2)
- interpolation (2)
- interval timing (2)
- interval training (2)
- intracellular bacterial pathogens (2)
- intracellular membranes (2)
- intracellular pathogens (2)
- intraoperative imaging (2)
- introgressive hybridization (2)
- intuition (2)
- invasive fungal infection (2)
- invasive fungal infections (2)
- inventory (2)
- ion channel (2)
- ipilimumab (2)
- irrigation (2)
- ischaemic stroke (2)
- ischemia-reperfusion injury (2)
- ischemia/reperfusion injury (2)
- ischemic penumbra (2)
- islet transplantation (2)
- islets of Langerhans (2)
- isocenter (2)
- isolation (2)
- isomerization (2)
- isothermal titration calorimetry (2)
- isotonic (2)
- isotopes (2)
- jet channel (2)
- jet reconstruction efficiency (2)
- jet transverse momentum (2)
- jets (2)
- joint aspiration (2)
- joint instability (2)
- judgements (2)
- juvenile hormone (2)
- keratinocytes (2)
- kidney cancer (2)
- kidney disease (2)
- kinase inhibitors (2)
- kinesin (2)
- kinetic model (2)
- knee osteoarthritis (2)
- knee replacement (2)
- laboratory techniques and procedures (2)
- lactate dehydrogenase (2)
- lactation (2)
- land surface (2)
- land surface temperature (2)
- land use intensification (2)
- land-use intensity (2)
- landsat (2)
- landscape heterogeneity (2)
- landscape metrics (2)
- language (2)
- language acquisition (2)
- laparostomy (2)
- large T antigen (2)
- large vessel occlusion (2)
- laser spectroscopy (2)
- late positive potential (2)
- late-onset (2)
- laterality (2)
- left ventricular ejection fraction (2)
- left ventricular mass (2)
- left-ventricular function (2)
- length of stay (2)
- lepidoptera (2)
- lessons learned (2)
- life (2)
- life cycle (2)
- life events (2)
- lifestyle (2)
- ligand (2)
- light pulses (2)
- lineage (2)
- linear regression analysis (2)
- linguistic morphology (2)
- lipid bilayer membrane (2)
- lipid metabolism (2)
- liquid biopsy (2)
- liquid chromatography/mass spectrometry (2)
- literature review (2)
- liver resection (2)
- lncRNAs (2)
- load management (2)
- locked-in state (2)
- locked-in syndrome (2)
- locomotor adaptation (2)
- locust outbreak (2)
- long non-coding RNA (2)
- long-term potentiation (2)
- long-term survivors (2)
- longitudinal studies (2)
- loss (2)
- low-grade glioma (2)
- lower body (2)
- lower extremity (2)
- lung-cancer (2)
- lying (2)
- lymph node dissection (2)
- lymphocyte differentiation (2)
- lyso-Gb3 (2)
- lysosomal storage disease (2)
- mRNA expression (2)
- mTOR (2)
- macrophage polarization (2)
- magic (2)
- magnesium (2)
- magnetic compass (2)
- magnetic resonance (2)
- main group element halides (2)
- maize (2)
- malignant hyperthermia (2)
- mammalian cells (2)
- mammalian genomics (2)
- maps (2)
- marcophages (2)
- marine bacteria (2)
- marine natural product (2)
- markers (2)
- mass (2)
- mass casualties (2)
- match load (2)
- materials for optics (2)
- maternal exposure (2)
- mathematical modeling (2)
- mating success (2)
- matrix metalloproteinase (2)
- matrix protein porin (2)
- maturation (2)
- meadow (2)
- mean-field theory (2)
- measels virus (2)
- measurement (2)
- measures (2)
- mechanisms of disease (2)
- media equation (2)
- mediated apoptosis (2)
- medical nutrition therapy (2)
- medical students (2)
- medieval manuscripts (2)
- medullary thyroid cancer (2)
- medullary thyroid carcinoma (2)
- medulloblastoma (2)
- megavoltage computed-tomography (2)
- melanomas (2)
- membrane biophysics (2)
- membrane receptor signaling (2)
- membrane skeleton (2)
- membrane vesicles (2)
- men (2)
- men who have sex with men (2)
- mentalizing (2)
- merocyanines (2)
- mesenchymal stem cell (2)
- mesenchymal stromal cell (2)
- metabolic disease (2)
- metabolic flux (2)
- metabolic flux analysis (2)
- metabolic syndrome (2)
- metabolomic profiling (2)
- metacognitive prompting (2)
- metacomprehension (2)
- metallic trace elements (2)
- metals (2)
- metamorphic buffer layer (2)
- metaproteomics (2)
- metastasis-directed therapy (2)
- metastatic (2)
- methodological pluralism (2)
- methods (2)
- methylprednisolone (2)
- miR (2)
- miR-182-5p (2)
- miR-21 (2)
- micelles (2)
- microbial ecology (2)
- microbial spectrum (2)
- microcephaly (2)
- microclimate (2)
- micronutrients (2)
- microparticles (2)
- microswimmer (2)
- microtubules (2)
- microvascular complications (2)
- microvasculature (2)
- midazolam (2)
- mimicry (2)
- mind–body intervention (2)
- mineral metabolism (2)
- minimal invasive surgery (2)
- mismatch (2)
- mitochondrial DNA (2)
- mixed hearing loss (2)
- mobile apps (2)
- mobile laser scanning (2)
- modeling (2)
- moderate (2)
- modifiers (2)
- modulation spectroscopy (2)
- molecular alterations (2)
- molecular beam epitaxy (2)
- molecular characterization (2)
- molecular cloning (2)
- molecular diagnostics (2)
- molecular epidemiology (2)
- molecular evolution (2)
- molecular mass (2)
- molecular mechanisms (2)
- molecular modeling (2)
- molecular phylogeny (2)
- molecular structure (2)
- molecular subtypes (2)
- monocyte (2)
- mood (2)
- morality (2)
- morphogenesis (2)
- morphogenetic protein (2)
- morris water maze (2)
- mosquito (2)
- motility (2)
- motivated reasoning (2)
- motoneuron (2)
- motor learning (2)
- motor proteins (2)
- mouse-brain (2)
- movement (2)
- movement disorder (2)
- mtDNA (2)
- mucoepidermoid carcinoma (2)
- multi-fluid mixture (2)
- multi-jet background (2)
- multi-sensor (2)
- multidrug resistance (2)
- multidrug-resistant bacteria (2)
- multimodal (2)
- multiparticle collision dynamics (2)
- multiple bonds (2)
- multiple-sclerosis (2)
- multivariate data analysis (2)
- muon channel (2)
- murine model (2)
- muscarinic receptors (2)
- muscle degeneration (2)
- muscle disease (2)
- musculoskeletal system (2)
- mutants (2)
- myasthenia gravis (2)
- mycotoxins (2)
- myeloid (2)
- myeloma (2)
- myocardial sympathetic innervation imaging (2)
- myocardial work (2)
- myocardial-infarction (2)
- myocardium (2)
- myofibrillar myopathy (2)
- myopathy (2)
- nab-paclitaxel (2)
- naloxone (2)
- nano rods (2)
- nanographene (2)
- nanomedicine (2)
- nanophotonics and plasmonics (2)
- nanotechnology (2)
- naphthylisoquinoline alkaloids (2)
- national park (2)
- national parks (2)
- natriuretic peptide (2)
- natural enemies (2)
- natural killer cells (2)
- natural language processing (2)
- natural pest control (2)
- necrobiome (2)
- necrotic cell death (2)
- negative pressure (2)
- neisseria gonorrhoeae (2)
- neoadjuvant (2)
- neonate (2)
- neonates (2)
- neovascularization, physiologic (2)
- nervous-system (2)
- nesting habits (2)
- networking (2)
- neume notation (2)
- neural circuits (2)
- neural crest (2)
- neural network (2)
- neural stem cell (2)
- neurite outgrowth (2)
- neuroendocrine tumor (NET) (2)
- neuroethology (2)
- neurofascin (2)
- neurofilaments (2)
- neuromodulation (2)
- neuronal dendrites (2)
- neuronal network (2)
- neuronal plasticity (2)
- neuroplasticity (2)
- neuropsychology (2)
- neurosphere (2)
- neurosurgery (2)
- neurotoxicity (2)
- neurotransmitter release (2)
- neurotrophic factors (2)
- neutral sphingomyelinase-2 (2)
- neutralino (2)
- neutrino astronomy (2)
- neutrino emission (2)
- neutrino telescope (2)
- neutrophil (2)
- next generation sequencing (NGS) (2)
- next-generation sequencing (2)
- nicotine addiction (2)
- nicotinic receptors (2)
- nilotinib (2)
- nivolumab (2)
- non-invasive ventilation (2)
- non-penetrating glaucoma surgery (2)
- non-small cell lung cancer (2)
- noncoding RNA (2)
- noncoding RNAs (2)
- noncovalent interactions (2)
- normal distribution (2)
- nuclear import (2)
- nuclear magnetic resonance (2)
- nuclear magnetic resonance spectroscopy (2)
- nuclear medicine (2)
- nuclear organization (2)
- nucleophilic addition (2)
- nucleosomes (2)
- nucleotide excision-repair (2)
- nucleotide sequence (2)
- nude-mice (2)
- numerical analysis (2)
- nurses (2)
- o-methoxy-sila-hexocyclium (2)
- object-based classification (2)
- object-based image analysis (2)
- occupational medicine/industrial medicine (2)
- oculomotor control (2)
- oestrogen receptor signalling (2)
- office-workers (2)
- olfactory memory (2)
- oligodendrocyte (2)
- oligorecurrence (2)
- olive (2)
- omega-3 fatty acids (2)
- oncogene-induced senescence (2)
- oncolytic virotherapy (2)
- one-electron oxidation (2)
- onset (2)
- open spaces (2)
- opioid peptides (2)
- optic neuritis (2)
- optical (2)
- optical coherence tomography (2)
- optical remote sensing (2)
- optics and photonics (2)
- optimal control theory (2)
- oral mucositis (2)
- organ-on-a-chip (2)
- organic electronics (2)
- organic solar cells (2)
- orientation (2)
- orthopedic surgery (2)
- oscillations (2)
- osteoclasts (2)
- osteonecrosis of the jaw (2)
- osteopontin (2)
- osteoradionecrosis (2)
- otitis media (2)
- outcomes research (2)
- outer membrane protein (2)
- outer membrane proteins (2)
- outer-membrane proteins (2)
- outpatients (2)
- oxaliplatin (2)
- oxidative addition (2)
- oxygen uptake (2)
- oxygen/glucose deprivation (2)
- oxytocin (2)
- pCa (2)
- paediatrics (2)
- pain sensation (2)
- paleogeography (2)
- palladium (2)
- palliative care (2)
- pandemic (2)
- panel sequencing (2)
- parallel evolution (2)
- parasitic cell cycles (2)
- paraspeckles (2)
- parastomal hernia (2)
- parasympatholytics (2)
- parietal hypoactivation (2)
- parotid gland (2)
- parthenogenesis (2)
- partial agonists (2)
- partial decay width (2)
- particles (2)
- passive transfer (2)
- pathogen (2)
- pathogenic bacteria (2)
- pathology (2)
- pathway analysis (2)
- patient education (2)
- patient reported outcome measures (2)
- patient safety (2)
- patient survival (2)
- patient-specific (2)
- peak oxygen uptake (2)
- pedagogical content knowledge (2)
- pediatric adrenocortical cancer (2)
- pediatric adrenocortical tumor (2)
- pediatric patients (2)
- peer review (2)
- pelvic examination (2)
- pelvic palpation (2)
- pembrolizumab (2)
- pemphigus foliaceus (2)
- penicillin allergy (2)
- penicillin hypersensitivity (2)
- pentacene (2)
- people (2)
- peptide tyrosine tyrosine (PYY) (2)
- peptide vaccination (2)
- peptides (2)
- perfusion culture (2)
- pericytes (2)
- periodization (2)
- perioperative care (2)
- peripartum (2)
- peripheral nerve (2)
- peripheral neuropathy (2)
- periprosthetic joint infection (2)
- peritoneal carcinomatosis (2)
- peroxisomes (2)
- personalised medicine (2)
- personalized treatment (2)
- perspective taking (2)
- perspectives (2)
- perylene bisimides (2)
- phage (2)
- pharmaceutical applications (2)
- pharmacology/toxicology (2)
- pharmacovigilance (2)
- phase transitions and critical phenomena (2)
- phasic affective modulation (2)
- phenprocoumon (2)
- pheromones (2)
- phosphatidylserine (2)
- phosphodiesterase (2)
- phosphorus (2)
- photoemission (2)
- photoemission spectroscopy (2)
- photolysis (2)
- photon statistics (2)
- photon-counting (2)
- photonic devices (2)
- photoreceptor (2)
- photoswitchable organic fluorophores (2)
- photosynthesis (2)
- photothrombosis (2)
- phototransduction (2)
- physical health (2)
- physical performance (2)
- physical properties (2)
- physiologically based pharmacokinetic (PBPK) modeling (2)
- phytochemicals (2)
- phytohormones (2)
- piRNA (2)
- piperacillin/tazobactam (2)
- piperidines (2)
- placebo-controlled trial (2)
- planning (2)
- plant cuticle (2)
- plant defence (2)
- plant defenses (2)
- plant diversity (2)
- plant–insect interactions (2)
- plaque (2)
- plasma proteins (2)
- plasminogen (2)
- plasmonics (2)
- platelet physiology (2)
- platelet receptors (2)
- platyhelminthes (2)
- plausibility (2)
- pleomorphic adenoma (2)
- pneumolysin (2)
- pneumonia (2)
- point of care testing (2)
- pointing gestures (2)
- policy (2)
- pollen tube (2)
- pollination network (2)
- pollinator decline (2)
- poly(2- oxazoline) (2)
- poly(2-ethyl-2-oxazoline) (2)
- polycationic peptides (2)
- polymavirus (2)
- polymer processing (2)
- polymorphisms (2)
- polymyalgia rheumatica (2)
- polyploidy (2)
- pomalidomide (2)
- population genetics (2)
- population-based (2)
- populations (2)
- pore formation (2)
- porin (2)
- positive selection (2)
- positron emission tomography/computed tomography (2)
- posterior parietal cortex (2)
- postmenopausal women (2)
- postnatal development (2)
- postoperative bleeding (2)
- postoperative care (2)
- postoperative nausea and vomiting (2)
- posttranslational modifications (2)
- postural control (2)
- potassium channel (2)
- power training (2)
- pp Collisions (2)
- pp collisions (2)
- pre-messenger RNA (2)
- precision agriculture (2)
- predation risk (2)
- predictive factors (2)
- predictive marker (2)
- predictive modeling (2)
- predictive performance (2)
- predictive value (2)
- preexisting bias (2)
- prenatal exposure (2)
- presynaptic inhibition (2)
- preterm infant (2)
- primary cells (2)
- primary healthcare (2)
- primary prevention (2)
- primary ventral hernia (2)
- primary vertex (2)
- priming (2)
- printability (2)
- printed tooth (2)
- probability (2)
- probes (2)
- proboscis extension response (PER) (2)
- processing fluency (2)
- prodrug (2)
- productivity (2)
- progenitor cells (2)
- progenitors (2)
- prognostic factors (2)
- projection neurons (2)
- promoter (2)
- promoter methylation (2)
- propensity score matching (2)
- propulsion (2)
- prosocial behavior (2)
- prospective studies (2)
- prostate-cancer (2)
- prostatic neoplasms (2)
- prosthesis (2)
- protease (2)
- protease inhibition (2)
- protein aggregation (2)
- protein interactions (2)
- protein phosphorylation (2)
- protein-coupled receptors (2)
- protein-interaction networks (2)
- protein-protein interactions (2)
- proteinuria (2)
- proteomes (2)
- proteomic (2)
- proton-proton collisions (2)
- proton-proton-collision (2)
- proton–proton collisions (2)
- proximal gradient method (2)
- psychoeducation (2)
- psycholinguistics (2)
- psychological variables (2)
- psychopathology (2)
- psychophysics (2)
- psychotherapy (2)
- puberty (2)
- public speaking (2)
- pulmonary artery pressure (2)
- pupae (2)
- pyrene (2)
- pyrolysis (2)
- qPCR (2)
- quality evaluation (2)
- quality of experience (2)
- quality of life (QoL) (2)
- quantitative SPECT/CT (2)
- quantitative analysis (2)
- quantity discrimination (2)
- quantum wells (2)
- qubits (2)
- quinine (2)
- quinoa (2)
- radiation sensitivity (2)
- radiation-therapy (2)
- radical cystectomy (2)
- radical prostatectomy (2)
- radii (2)
- radiography (2)
- radioiodine (2)
- radiopharmaceuticals (2)
- radiotherapy (RT) (2)
- radiotracer (2)
- rainforest (2)
- raman spectroscopy (2)
- random forest classification (2)
- randomised controlled trial (2)
- randomized trial (2)
- rapid prototyping (2)
- rare (2)
- rare diseases (2)
- rat brain membranes (2)
- rat hepatocytes (2)
- rat model (2)
- re-irradiation (2)
- reaction mechanism (2)
- reaction mechanisms (2)
- reactivation (2)
- reactive electrophilic species (2)
- reactive intermediates (2)
- reading comprehension (2)
- reading disability (2)
- real time PCR (2)
- real world evidence (2)
- receptor beta (2)
- receptor signalling (2)
- receptor tyrosine kinase (2)
- reconstructed human epidermis (2)
- rectum (2)
- red fluorescent protein (2)
- redox (2)
- reflection (2)
- reflex (2)
- refugees (2)
- regenerative capacity (2)
- regional development (2)
- register (2)
- registries (2)
- registry (2)
- regulator (2)
- regulatory RNA (2)
- regulatory T cell (2)
- regurgitation (2)
- reinforcement learning (2)
- relativistic jets (2)
- relaxation (2)
- release (2)
- religion (2)
- remyelination (2)
- renal cancer (2)
- renal disease (2)
- renal failure (2)
- renal system (2)
- renewable energy (2)
- renewable fuels (2)
- repair and replication (2)
- reperfusion (2)
- reperfusion injury (2)
- replacement therapy (2)
- replica (2)
- replication crisis (2)
- reporter genes (2)
- reporting and data system (2)
- repositories (2)
- reproductive success (2)
- resin (2)
- resonant tunneling diode (2)
- resource use (2)
- respiratory chain (2)
- respiratory syncytial virus (2)
- restrictive cardiomyopathy (2)
- resveratrol (2)
- retention interval (2)
- retinitis pigmentosa (2)
- retinoblastoma protein (2)
- retinoic acid (2)
- retrospective (2)
- retroviral vectors (2)
- reverse shoulder arthroplasty (2)
- reverse transcriptase (2)
- reverse transcriptase-polymerase chain reaction (2)
- reversible posterior leukoencephalopathy syndrome (2)
- revision arthroplasty (2)
- rheology (2)
- ribonucleases (2)
- ribosome biogenesis (2)
- riboswitch (2)
- rice (2)
- ring-expansion reaction (2)
- robotic surgery (2)
- roentgenographic assessment (2)
- rolipram (2)
- room temperature (2)
- root (2)
- root growth (2)
- rotation (2)
- ruthenium bda complexes (2)
- ruthenium complexes (2)
- saccharomyces cerevisiae (2)
- safety behavior (2)
- salicylic acid (2)
- salinity stress (2)
- salivary gland (2)
- salivary gland tumors (2)
- sampling method (2)
- sarcoidosis (2)
- satellite (2)
- satellite remote sensing (2)
- satisfaction with life (2)
- scaffolds (2)
- scalability (2)
- scapula (2)
- sciatic nerve (2)
- scientific guidelines (2)
- sclerostin (2)
- scoping review (2)
- search (2)
- second hit (2)
- secondary metabolites (2)
- secretion systems (2)
- sectoral planning (2)
- sedentary behavior (2)
- sedimentology (2)
- see (2)
- selective attention (2)
- selenium (2)
- self-adaptive systems (2)
- self-aware computing (2)
- self-help (2)
- self-management (2)
- self-renewal (2)
- semantic coherence (2)
- semi-natural habitats (2)
- sensitivity analysis (2)
- sensor (2)
- sensor fusion (2)
- sensory neuropathy (2)
- sensory perception (2)
- sentinel-2 (2)
- septic (2)
- sequence analysis (2)
- serology (2)
- serum concentration (2)
- serum creatinine (2)
- sevoflurane (2)
- sex chromosome evolution (2)
- sex determination (2)
- sex differentiation (2)
- sexual development (2)
- shape fidelity (2)
- shedding (2)
- short-term memory (2)
- shoulder (2)
- shoulder arthroplasty (2)
- shoulder surgery (2)
- sialic acid (2)
- signal cross section (2)
- signal filtering (2)
- signal inhibition (2)
- signal to noise ratio (2)
- signaling pathways (2)
- signalling pathways (2)
- signals (2)
- signature (2)
- signs and symptoms (2)
- silahexocyclium (2)
- simulated signal event (2)
- simultaneous integrated boost (2)
- single photon (2)
- single top event (2)
- single top production (2)
- single top quark production (2)
- single-cell RNA-seq (2)
- single-nucleotide polymorphisms (2)
- single-sided deafness (2)
- sirolimus (2)
- site-specific RNA cleavage (2)
- sizing (2)
- skinned fiber (2)
- sleep bruxism (2)
- sleep disorders (2)
- small RNAs (2)
- small nucleolar RNAs (2)
- small-molecule activation (2)
- smart speaker (2)
- smartphone app (2)
- smooth muscle cells (2)
- social capital (2)
- social context (2)
- social decision-making (2)
- social features (2)
- social influence (2)
- social psychology (2)
- sodium channel (2)
- sodium channels (2)
- sofosbuvir (2)
- soil (2)
- solid tumors (2)
- solid-state NMR (2)
- solid-state emitters (2)
- solitary bee (2)
- solitary bees (2)
- solvent effects (2)
- somatic mosaicism (2)
- somatostatin receptor (SSTR) (2)
- soybean (2)
- spacing effect (2)
- spatial attention (2)
- spatial navigation (2)
- spatial presence (2)
- speciation (2)
- species concept (2)
- species diversity (2)
- spectral karyotyping (2)
- speech perception (2)
- speed (2)
- sperm DNA methylation (2)
- spermatocytes (2)
- spermatogenesis (2)
- spheroids (2)
- sphingolipid (2)
- sphingosine kinase inhibitor SKI-II (2)
- sphingosine-1-phosphate (2)
- spider (2)
- spider phobia (2)
- spin (2)
- spin polarization (2)
- spinal cord injury (2)
- spinal-cord (2)
- spinal-cord-injury (2)
- spine (2)
- spine radiosurgery (2)
- spin–orbit coupling (2)
- spiral ganglion neuron (2)
- splicing (2)
- split-belt treadmill (2)
- spontaneous symmetry breaking (2)
- sporidia (2)
- squaraine dyes (2)
- stage renal-disease (2)
- standardization (2)
- startle (2)
- state (2)
- stem cell niche (2)
- stent (2)
- stereochemistry (2)
- stereotypes (2)
- stiffness (2)
- stimuli (2)
- streptozotocin (2)
- stress resilience (2)
- stress resistance (2)
- stress response (2)
- strong coupling (2)
- strongly correlated materials (2)
- structural basis (2)
- structural synaptic plasticity (2)
- structure prediction (2)
- structure-activity (2)
- structure-activity relationship (2)
- structure-activity relationships (2)
- structured illumination (2)
- structured illumination microscopy (2)
- student training (2)
- study design (2)
- sturgeon (2)
- subcutaneous animal model (2)
- substantia nigra pars compacta (2)
- succession (2)
- suicide prevention (2)
- sulfates (2)
- sun exposure (2)
- supervisors (2)
- support vector machines (2)
- suppressor cells (2)
- supraglacial lakes (2)
- supraparticles (2)
- surgical site infections (2)
- surgical therapy (2)
- surgical treatment (2)
- survival analysis (2)
- survivors (2)
- susceptibility gene (2)
- sustainability (2)
- sustainable agriculture (2)
- sustainable intensification (2)
- sustained inflammation (2)
- swarming (2)
- swimming (2)
- symptom control (2)
- synapse formation (2)
- synapsis (2)
- synaptonemal complex (2)
- syndrome (2)
- synergistic effect (2)
- synovial fluid (2)
- synthetic aperture RADAR (2)
- synthetic aperture radar (2)
- synthetic biology (2)
- synthetic mesh (2)
- synthetic methods (2)
- systematics (2)
- targeted therapies (2)
- targeting (2)
- targets (2)
- task force (2)
- taste (2)
- teacher education (2)
- telecommunication spectral range (2)
- temporal processing (2)
- temporal-lobe epilepsy (2)
- temporoparietal junction (2)
- tendon (2)
- tension (2)
- teriparatide (2)
- terror attack (2)
- testes (2)
- testis (2)
- tetraspanin (2)
- tetromycin (2)
- textile (2)
- the rich (2)
- theory (2)
- theory of mind (2)
- therapy response (2)
- thin films (2)
- thinking (2)
- thorax (2)
- thromboinflammation (2)
- thrombolysis (2)
- thrombopoiesis (2)
- thyroid cancer (2)
- time (2)
- time perception (2)
- time-resolved spectroscopy (2)
- time-series (2)
- timing (2)
- tissue saturation index (2)
- tocilizumab (2)
- tolerability (2)
- toll-like receptors (2)
- tool use (2)
- tooth extraction (2)
- top quark (2)
- top quark decay (2)
- topic modeling (2)
- total joint arthroplasty (2)
- toxicology (2)
- toxin (2)
- trabectome (2)
- trabecular meshwork (2)
- trace elements (2)
- tracking (2)
- trade-offs (2)
- training intensity distribution (2)
- transactivation (2)
- transcription factor MIZ-1 (2)
- transcriptional control (2)
- transcriptional profiling (2)
- transcriptome analysis (2)
- transfection (2)
- transformation (2)
- transformative education (2)
- transforming growth factor-beta 1 (2)
- transient middle cerebral artery occlusion (2)
- transition (2)
- transition metal oxides (2)
- transition radiation (2)
- translation initiation (2)
- translational initiation (2)
- translational regulation (2)
- transportation (2)
- transposition (2)
- trap (2)
- trap nests (2)
- trastuzumab (2)
- treatment guidelines (2)
- treatment options (2)
- treatment resistance (2)
- trees (2)
- trend analysis (2)
- triple in situ hybridization (2)
- triple-negative breast cancer (2)
- tropical forest (2)
- trust (2)
- trypanosoma brucei (2)
- tuberculosis (2)
- tumor cells (2)
- tumor growth (2)
- tumor immunity (2)
- tumor immunology (2)
- tumor necrosis factor (TNF) (2)
- tumor stem cells (2)
- tumor-infiltrating lymphocytes (2)
- tumour immunology (2)
- two-photon absorption (2)
- two-photon excited fluorescence (2)
- two-stage exchange (2)
- type VII secretion system (2)
- tyrosine (2)
- tyrosine kinase inhibitor (2)
- tyrosine kinase inhibitors (2)
- ultrafiltration (2)
- umbilical hernia (2)
- unconventional superconductivity (2)
- unexpressed needs (2)
- unfolded protein response (2)
- universal prevention (2)
- unmanned aerial vehicles (2)
- unpleasant pictures (2)
- up-regulation (2)
- update (2)
- urban (2)
- urine (2)
- urticaria (2)
- user study (2)
- vaccines (2)
- vacuum conditioning (2)
- vacuum-assisted closure (2)
- vandetanib (2)
- vascular access (2)
- vascular permeability (2)
- vascular plants (2)
- vascular surgery (2)
- vasculature (2)
- vasculogenesis (2)
- vasopressin (2)
- vegetative state (2)
- venous system (2)
- ventral hernia (2)
- vertebral metastases (2)
- vertigo (2)
- very-long-baseline interferometry (2)
- vibration (2)
- vicinal surfaces (2)
- video analysis (2)
- virology (2)
- virtual agent (2)
- virtual body ownership (2)
- virulence factors (2)
- viscosity (2)
- visible cross section (2)
- vitamin D deficiency (2)
- vitamins (2)
- volatile anesthetics (2)
- volume regulation (2)
- voluntary movement (2)
- von Willebrand factor (2)
- vulnerability (2)
- vulnerability curve (2)
- wR factor = 0.068 (2)
- water load test (2)
- water microbiology (2)
- water splitting (2)
- wave functions (2)
- weakly coordinating anions (2)
- wetland (2)
- white blood cells (2)
- whole exome sequencing (2)
- whole genome sequencing (2)
- whole-exome sequencing (2)
- whole-genome duplication (2)
- wind speed (2)
- wood anatomy (2)
- wood-inhabiting fungi (2)
- work capacity evaluation (2)
- work engagement (2)
- workplace (2)
- wound healing (2)
- xenotransplantation (2)
- xylem loading (2)
- yam (2)
- yellow fluorescent protein (2)
- yoga (2)
- young children (2)
- youth (2)
- zoology (2)
- γδ T cell (2)
- γδ T cells (2)
- π-conjugated systems (2)
- ( L. ivanovii ) (1)
- ( L. selligeri) (1)
- (+)-limonene (1)
- (13)C (1)
- (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium chloride/pharmacology (1)
- (AB)\(_{n}\) segmented copolymers (1)
- (Mouse L-cell) (1)
- (Nucleotide sequence (1)
- (R)- and (S)-hexahydro- / Antimuscarinic properties / Muscarinic receptor subtypes (1)
- (Rat brain membrane) (1)
- (Rat liver) (1)
- (Salmonella) (1)
- (approximate) functional equation (1)
- (cardiac) surgery (1)
- (classical and atypical) Werner syndrome (1)
- (dis-)embeddedness (1)
- (± )-dioncophyllacine A (1)
- + (1)
- 0 antigen (1)
- 1,2-additionreaction (1)
- 1,2-azaborinine (1)
- 1,2-benzisothiazolinone (1)
- 1,25-dihydroxyvitamin D\(_{3}\) (1)
- 1,4-Diborabenzene (1)
- 1,4-naphthoquinone (1)
- 1/N expansion (1)
- 11C-HED (1)
- 11C-Hydroxyephedrine (1)
- 11C-Methionine PET/CT (1)
- 11C-hydroxyephedrine (1)
- 12-oxo-phytodienoic acid (1)
- 123I-Ioflupane (1)
- 131I (1)
- 133Ba (1)
- 14.7K (1)
- 15-Deoxyspergualin (1)
- 1550 nm (1)
- 16S metabarcoding (1)
- 16S ribosomal-RNA (1)
- 177Lu SPECT/CT imaging (1)
- 17ßEstradiol (1)
- 18-F-fluorothymidine uptake (1)
- 18F-DCFPL (1)
- 18F-DCFPyL (1)
- 18F-flurpiridaz (1)
- 18FDG-PET/CT (1)
- 18FFBnTP (1)
- 18S (1)
- 1960s (1)
- 1H-Magnetic resonance spectroscopy (1H-MRS) (1)
- 1p13.3 (1)
- 1p36 deletion syndrome (1)
- 1q21 (1)
- 1st International Workshop (1)
- 1st-line treatment (1)
- 2 Jets (1)
- 2 PM (1)
- 2',7'-dichlorofluorescin (1)
- 2,5-diketopiperazines (1)
- 2- deoxy-2-(18F)fluoro-D-glucose (1)
- 2-APB (1)
- 2-Acetylaminofluorene (1)
- 2-DG (1)
- 2-Dichloroethane (1)
- 2-Dioxetane (1)
- 2-Generation reproduction (1)
- 2-Thiazaphospholidines (1)
- 2-alkylbranched acids (1)
- 2-chloro (1)
- 2-component system (1)
- 2-deoxy-2-(18F)fluoro-D-glucose (1)
- 2-deoxy-2-18F-fluoro-D-sorbitol (1)
- 2-deoxy-D-glucose (1)
- 2-dimensional speckle tracking (1)
- 2-halo (1)
- 2-imino- (1)
- 2-loop level (1)
- 2-photon absorption (1)
- 2-photon microscopy (1)
- 2-pore potassium channel (1)
- 2-step IMRT (1)
- 2015 (1)
- 21q22.2-q22.3 (1)
- 223Ra (1)
- 224Ra (1)
- 22q11.2 deletion syndrome (1)
- 25-hydroxycholesterol 7 alpha-hydroxylase (1)
- 26S RDNA Data (1)
- 26S proteasome (1)
- 28 (1)
- 2D-perfusion angiography (1)
- 2Dimensionale Spektroskopie (1)
- 2ϕ\(_0\) periodicity (1)
- 3 (1)
- 3 D rotational fluoroscopy (1)
- 3-coordinate boron (1)
- 3-coordinate organoboron compounds (1)
- 3-dimensional MRI (1)
- 3-dimensional structure (1)
- 3-dimensional visualization (1)
- 316L stainless-steel (1)
- 360° videos (1)
- 3D (1)
- 3D GIS analysis (1)
- 3D Printing (1)
- 3D X-ray microscopy (1)
- 3D analysis (1)
- 3D breast cancer model (1)
- 3D cell culture (1)
- 3D cell cultures (1)
- 3D collation (1)
- 3D conformal silicone bolus (1)
- 3D culture (1)
- 3D echocardiography (1)
- 3D electrophysiology (1)
- 3D ex vivo models (1)
- 3D image analysis (1)
- 3D in vitro model (1)
- 3D in vitro models (1)
- 3D lung tumor tissue models (1)
- 3D mapping (1)
- 3D microfiber (1)
- 3D model systems (1)
- 3D modeling (1)
- 3D neuronal networks (1)
- 3D object recognition (1)
- 3D organoids (1)
- 3D powder printing (1)
- 3D printer (1)
- 3D remote sensing (1)
- 3D tissue models (1)
- 3D tumor model (1)
- 3D viewer (1)
- 3D-conformal radiotherapy (1)
- 3D-printed tooth (1)
- 3D-reconstruction methods (1)
- 3DTK toolkit (1)
- 3R (1)
- 3 T (1)
- 3‐D electrical resistivity imaging (1)
- 3′ UTR (1)
- 4'-hydroxylation (1)
- 4-(p-nitrobenzyl)pyridine (1)
- 4-dimethylamino-4′-cyanodiphenylacetylene (1)
- 4D (1)
- 4D flow MRI (1)
- 4D flow cardiovascular magnetic resonance (1)
- 4D-GIS (1)
- 4D-MRI (1)
- 4H (1)
- 4TH-Corner Problem (1)
- 5-HT (1)
- 5-HT receptors (1)
- 5-HTT (1)
- 5-HTT knockout mice (1)
- 5-HTTLPR polymorphism (1)
- 5-bromodeoxyuridine (1)
- 5-methyl cytosine (1)
- 5-methylcytosine (1)
- 5HTTLPR (1)
- 5IA-SPECT (1)
- 6-benzylaminopurine (1)
- 6-percent hydroxyethyl starch (1)
- 60-nucleotide duplication (1)
- 65-kda isoform (1)
- 68Ga-DOTATATE (1)
- 68Ga-DOTATATE/-TOC (1)
- 68Ga-PSMA ligand PET/CT (1)
- 68Ga-Pentixafor PET/CT (1)
- 6S RNA (1)
- 7 T (1)
- 7000 GeV-cms (1)
- 77-LH-28-1 (1)
- 7T (1)
- 7q11.2 (1)
- 8 TEV (1)
- 8-Hydroxy-deoxyguanosine (1)
- 8-oxoguanine (1)
- 99mTc-DTPA (1)
- <sup>18</sup>F-FDG (1)
- <sup>68</sup>Ga-Pentixafor (1)
- A chromosomes (1)
- A(2B) receptors (1)
- A-D (1)
- A-delta fibers (1)
- A-type lamins (1)
- A. thaliana (1)
- A1 (1)
- A1 Adenosine receptors (1)
- A20 (1)
- A2a-R receptor (1)
- A375 (1)
- A53T (1)
- A549 cell line (1)
- A<sub>2</sub> Adenosine receptor (1)
- AAA+ ATPase p97 (1)
- AAPA (1)
- ABA receptors (1)
- ABL gene (1)
- ABP1 (1)
- AC Stark effect (1)
- ACC (1)
- ACC deaminase (1)
- ACC/AHA classification (1)
- ACE inhibitor (1)
- ACH-2 (1)
- ACID (1)
- ACKR4 (1)
- ACM (1)
- ACP5 (1)
- ACPC (1)
- ACR practice guidelines (1)
- AChE inhibitor (1)
- AD mouse modele (1)
- AD pathogenesis (1)
- AD-AID (1)
- AD5 mutation (1)
- ADAM10 (1)
- ADAM9 (1)
- ADAMTS (1)
- ADCC (1)
- ADHD patients (1)
- ADME analysis (1)
- ADP-ribosylation toxins (1)
- ADP-ribosyltransferases (1)
- AF-DX 116 (1)
- AFLP (1)
- AG(110) (1)
- AGP (1)
- AGT (1)
- AHRR (1)
- AICDA (1)
- AID-ΔE4a (1)
- AIE (1)
- AIME (1)
- AIModules (1)
- AIRWAYS ICPs (1)
- AKI (1)
- AKT-signaling (1)
- AKT1 (1)
- ALAN (1)
- ALI culture (1)
- ALK-1 (1)
- ALMT (1)
- ALOS (1)
- ALOS-2 (1)
- ALPH (1)
- ALPH1 (1)
- ALPL (1)
- ALS mimic (1)
- ALS treatment (1)
- ALSIN gene (1)
- ALT (1)
- ALiOS (1)
- AMP-activated kinases (1)
- ANOVA (1)
- ANTARES telescope (1)
- AOM/DSS (1)
- AP-1 (1)
- APC (1)
- APERIO (1)
- APERIO Hybrid (1)
- APEX2 (1)
- API (1)
- APOBEC3G (1)
- APRI (1)
- AQP4 (1)
- ARCI (1)
- ARCI EM type III (1)
- ARDS (acute respiratory distress syndrome) (1)
- ARF (1)
- ARF tumor-suppressor induced lymphomagenes (1)
- ART outcome (1)
- ARVC (1)
- AS clavicle plate (1)
- ASAR (1)
- ASCAT (1)
- ASCs (1)
- ASE formula (1)
- AT/RT (1)
- ATF6 (1)
- ATG (1)
- ATG proteins (1)
- ATG12-ATG5 conjugate (1)
- ATG7 (1)
- ATG8 (1)
- ATLAS experiment (1)
- ATM (1)
- ATM gene (1)
- ATMP (1)
- ATP carrier (1)
- ATP generation (1)
- ATP synthase (1)
- ATP-DnaA complex (1)
- ATP-adenosine triphosphate (1)
- ATP-binding cassette transporter (1)
- ATPase activity (1)
- ATPase mutants (1)
- ATRX (1)
- ATTRv amyloidosis (1)
- AUX1 (1)
- AVA (1)
- AVHRR data (1)
- AYAs (1)
- AZD4547 (1)
- AZD6244 (1)
- A\(_{2A}\) adenosine receptor antagonist (1)
- Aaskäfer (1)
- Ab interno trabeculectomy (1)
- Abatacept (1)
- Abelson helper integration-1 (AHI1) (1)
- Ableitung (1)
- Abstandsmessung (1)
- Accelerator modelling and simulations (multi-particle dynamics; single-particle dynamics) (1)
- Accelerometry (1)
- Accidental coincidence (1)
- Accountability (1)
- Accumulative Femtosecond Spectroscopy (1)
- Accurate (1)
- Acene (1)
- Acer platanoides (1)
- Acetabularia (1)
- Acetylated tubulin (1)
- Achilles tendinopathy (1)
- Acids (1)
- Acipenser baerii (1)
- Acoustics (1)
- Acquisition of literacy (1)
- AcrAB-TolC efflux pump (1)
- Acromesomelic dysplasias (1)
- Acromyrmex ambiguus (1)
- Acromyrmex heyeri (1)
- Actin nucleation (1)
- Actinokineospora (1)
- Actinomycin D (1)
- Action feedback (1)
- Action potentials (1)
- Active disease (1)
- Acute Myocardial Infarction (1)
- Acute lymphoblastic leukemia (1)
- Acute myeloid leukemia (AML) (1)
- Acute osteomyelitis (1)
- Acute tryptophan depletion (1)
- AdS-CFT correspondence (1)
- Adamantiades-Behçet disease (1)
- Adaptation (1)
- Adaptive cell transfer (1)
- Addison's disease (1)
- Addisons disease (1)
- Adenocarcinomas (1)
- Adenosine receptor (1)
- Adenosine receptor antagonists (1)
- Adenosinrezeptor (1)
- Adenovirus (1)
- Adenylate cyclase toxin (1)
- Adherence (1)
- Adherens junction (1)
- Adhesion (1)
- Adhäsion (1)
- Adipokine (1)
- Adipositas (1)
- Adolescence (1)
- Adolescent (1)
- Adolescents (1)
- Adrenocortial carcinomas (1)
- Adrenocortical Carcinoma (1)
- Adult head (1)
- Adult patients (1)
- Adults (1)
- Advanced snowmelt (1)
- Affective processing (1)
- Afferent nerve stimulation (1)
- Afghanistan (1)
- Aflatoxin (1)
- Aflatoxin B1 (1)
- Africa south of the equator (1)
- African agriculture (1)
- African sleeping sickness (1)
- African trypanosome (1)
- African trypanosomes (1)
- African-americans (1)
- Ag(111) (1)
- Ag-DNA (1)
- Agalsidase beta therapy (1)
- Age (1)
- Ageing (1)
- Aggeneys (1)
- Aggression (1)
- Aggressive behaviour (1)
- Aging (1)
- Agoraphobia (1)
- Agricultural intensification (1)
- Agricultural soil science (1)
- Agro-ecology (1)
- Agrobacterium (1)
- Ahmed (1)
- Akt/PKB (1)
- Akutes Nierenversagen (1)
- Albino rat (1)
- Alcohol dependence (1)
- Aldehyde Bioconjugation (1)
- Aldehyde Complexes (1)
- AldoA (1)
- Alemtuzumab (1)
- Alento hydrological observatory (1)
- Alien limb syndrome (1)
- Alkaline phosphatase (1)
- Alkekengi (1)
- Alkohol (1)
- Alkyl(amino)carbene (1)
- Alkylation (1)
- Alkyltransferase Ribozyme SAMURI (1)
- Alkyne (1)
- Allelic loss (1)
- Allergic rhinitis (1)
- Allergie (1)
- Allergy (1)
- Allogeneic transplantation (1)
- Allophrynidae (1)
- Allorhizobium vitis (1)
- Allotransplantation (1)
- Alpelisib (1)
- Alpen (1)
- Alpha galactosidase (1)
- Alpha therapy (1)
- Alpha-Galactosidase (1)
- Alpha-dependent apoptosis (1)
- Alpha-galactosidase (1)
- Alpha-synuclein oligomers (1)
- Alpine habitats (1)
- Altenpflege (1)
- Alternaria (1)
- Alternative test methods (1)
- Aluminium-copper (1)
- Alvis (1)
- Alzheimer's diseas (1)
- Alzheimer-Krankheit (1)
- Alzheimers-disease (1)
- Alzheimer’s dementia (1)
- Alzheimer′s disease (1)
- AmGr1 (1)
- AmGr2 (1)
- AmGr3 (1)
- Amantadine (1)
- Amazon Molly (1)
- Amazonia (1)
- Amazonian forest (1)
- American Thyroid Association (1)
- American foulbrood (1)
- Amino acid composition (1)
- Aminosäuren (1)
- Ampfer (1)
- Amphibia (1)
- Amphibians (1)
- Amplitude (1)
- Amu Darya (1)
- Amygdala (1)
- Amyloid-beta oligomers; (1)
- Amyotrophic Lateral Sclerosis (ALS) (1)
- Amyotrophic Lateral Sclerosis Assessment Questionnaire 5 (ALSAQ-5) (1)
- Amyotrophic-lateral-sclerosis (1)
- Anabolieagent (1)
- Analgesia (1)
- Analytical Quality by Design (1)
- Anaphylactic shock (1)
- Anarchic limb syndrome (1)
- Anas crecca (1)
- Anatomic reattachment (1)
- Anchimeric assistance in solvolysis (1)
- Ancistrocladus ealaensis (1)
- Ancistrocladus likoko (1)
- Andalusian varieties (1)
- Anderson-Fabry Disease (1)
- Aneuploidy (1)
- Angiopoietin-2 (1)
- Angiopoietin-like 4 (1)
- Angiosperms ; Ant-plant interactions ; domatia ; Flora of Malaysia (1)
- Angola (1)
- Angst (1)
- Aniline derivatives (1)
- Animal Tracking (1)
- Animal behavior (1)
- Animal studies (1)
- Ankyrin (1)
- Anomalous magnetic-moment (1)
- Anoplolepis gracilipes (1)
- Anorexia nervosa (1)
- Ant-following birds (1)
- Ant-plant interactions (1)
- Ant-plant interactions ; Herbivory Macaranga ; Mutualism ; Myrmecophytes (1)
- Ant/plant interaction (1)
- Anterior chamber perfusion model (1)
- Anterior inferotemporal cortex (1)
- Anthraquinone glycosides (1)
- Anti-TNF-alpha agents (1)
- Anti-tank rocket (1)
- Anti-tank weapon (1)
- Antibacterial therapy (1)
- Antibacterials (1)
- Antibiotic resistance (1)
- Antibiotics (1)
- Antibodies (1)
- Antibody index (1)
- Anticoagulants (1)
- Antidepressants (1)
- Antigen 4 (1)
- Antioxidants (1)
- Antiparanodal Autoantibodies (1)
- Antisense (1)
- Antisocial behavior (1)
- Antiviral nucleoside analogues (1)
- Anxiety sensitivity (1)
- Anxiety-like behavior (1)
- Anxiolysis (1)
- Any Evil (1)
- Anästhesiologie (1)
- Aorta (1)
- Aortic arch (1)
- ApaH (1)
- ApaH like phosphatase (1)
- Aphthae (1)
- Apicomplexan (1)
- Apidae (1)
- Apis dorsata (1)
- Aplastic anemia (1)
- ApoE\(^{(-/-)}\) (1)
- Apple Watch 7 (1)
- Applied physics (1)
- Aquaporin-4 antibodies (AQP4-Ig, NMO-IgG)G (1)
- Aquaporin-4 antibodies (AQP4-IgG) (1)
- Aquaporin-4 antibodies (AQP4-IgG, NMO-IgG) (1)
- Aqueous Solution Photochemistry (1)
- Arabidopsis-thaliana (1)
- Araneidae (1)
- Araneus diadematus (1)
- ArcCHECK (1)
- Archaea (1)
- Archaeology (1)
- Arctic (1)
- Arena experiment (1)
- Argentina (1)
- Arginine (1)
- Argonaute (1)
- Aromatic-hydrocarbon (1)
- Aromaticity (1)
- Arp2/3 complex (1)
- Arrhenius equation (1)
- Arterial Diameters (1)
- Arterial water (1)
- Arterioles (submucosal) (1)
- Arthrography (1)
- Arthroleptis amphibia (1)
- Arthropod (1)
- Arthropods (1)
- Arthur Hailey (1)
- Articular afferent (1)
- Articular-Cartilage (1)
- Artificial Nuclear Pores (1)
- Aryl hydrocarbon rnonooxygenase (1)
- Arylborylene Complexes (1)
- Asc-1 transporter (1)
- Ascaris lumbricoides (1)
- Aseptic loosening (1)
- Asia (1)
- Asian Englishes (1)
- Aspartate Aminotransferases (1)
- Aspergillus fumigalus (1)
- Aspergillus medium (1)
- Aspergillus niger (1)
- Aspergillus sp. (1)
- Assay (1)
- Assemblages (1)
- Association study (1)
- Associative learning (1)
- Astrocytes ; Schwann cells ; Interferon-gamma ; Fibroblast growth factor ; Cyclic AMP (1)
- Astrocytic tumor (1)
- Astrophysical neutrino sources (1)
- Asymmetrie (1)
- Atacama (1)
- Ataxia (1)
- Atharvaveda (1)
- Atherosclerosis (1)
- Atherosclerosis, intracranial arteries (1)
- Atherosclerotic plaque (1)
- Atmospheric muons (1)
- Atomic force microscopy (1)
- Atria (1)
- Atrial fibrillation (1)
- Atrial natriuretic peptide (1)
- Attention (1)
- Attention Deficit Hyperactivity Disorder (ADHD) (1)
- Attention-deficit/hyperactivity disorder (1)
- Attentional performance (1)
- Attitude (1)
- Attitude Heading Reference System (AHRS) (1)
- Au/Ge(111) (1)
- Auditory pathway (1)
- Auditory targets (1)
- Augenkrankheit (1)
- Aulonocara (1)
- Aureobasidium (1)
- AurisID (1)
- Australian stingless bees (1)
- Autism (1)
- Auto-antibodies (1)
- Autoimmune diseases (1)
- Autoimmune-Diseases (1)
- Autoinflammation (1)
- Autologous (1)
- Automated analysis (1)
- Automatization (1)
- AuxRE (1)
- Auxin-regulated transcription (1)
- Available soil water capacity (1)
- Aversive events (1)
- Aversive tension (1)
- Aviophobia (1)
- Avirulent Salmonella (1)
- Avoidance behavior (1)
- Axl tyrosine kinase (1)
- Axon growth (1)
- Axon guidance (1)
- Axonal transport (1)
- Azathioprine (1)
- Aziridines (1)
- Aššur (1)
- Aδ- and C-fibers (1)
- B (1)
- B 37 CAG repeat locus (1)
- B cell culture (1)
- B cell deficiency (1)
- B cell malignancies (1)
- B cell maturation (1)
- B cell receptor (1)
- B cell receptor (BCR) (1)
- B neisseria meningitidis (1)
- B physics (1)
- B,N-heterocycles (1)
- B,N-heterocylcles (1)
- B-0 (1)
- B-B bond (1)
- B-B bond activation (1)
- B-MYB (1)
- B-cell (1)
- B-lymphocytes (1)
- B-tagged jet (1)
- B4GALT7 gene (1)
- B7-H1 Antigen (1)
- BAL (1)
- BARF-mutated melanoma (1)
- BB/OKL rats (1)
- BBC3 (1)
- BCL-X-L P53 (1)
- BCOR (1)
- BCORL1 (1)
- BCR-ABL (1)
- BCR‐ABL (1)
- BDNF Val66Met (1)
- BDNF stimulation (1)
- BET Inhibitor (1)
- BETA(2)-adrenergic receptor (1)
- BH3 domains (1)
- BH3-only proteins (1)
- BIRC7 (1)
- BK channel (1)
- BK virus (1)
- BM (1)
- BMI (1)
- BMP antagonist (1)
- BMP signaling (1)
- BMP-2 delivery (1)
- BMP-6 (1)
- BMPR1B (1)
- BN 52021 (1)
- BNIP3 (1)
- BON-1 (1)
- BP180 (1)
- BPD (1)
- BPM (1)
- BPMN (1)
- BRAF mutations (1)
- BRAF(V600E) mutation (1)
- BRCA1 positive (1)
- BRCA1/2 (1)
- BRCA1/2 negative (1)
- BRCA2 positive (1)
- BRD4 (1)
- BRIP1 gene (1)
- BRM (1)
- BRN-3A (1)
- BSA (1)
- BSM Higgs boson (1)
- BSS directive (1)
- BSTA (1)
- BTN (1)
- BTN2 (1)
- BTN2A1 (1)
- BTN3A1 (1)
- BT_1884 (1)
- BV-2 (1)
- BaPb\(_{1-X}\)Bi\(_{X}\)O\(_{3}\) (1)
- Babylon (1)
- BacT/ALERT (1)
- Bacillus megaterium (1)
- Bacillus subtilis (1)
- Bacillus-Calmette-Guerin (1)
- Bacillus-subtilis (1)
- Background Epithelioid haemangioma (1)
- Bacteria (1)
- Bacterial conjugation (1)
- Bacterial meningitis (1)
- Bacterial symbionts (1)
- Bacteriaophage AR9 (1)
- Baerveldt (1)
- Baja California [(PNN) Mexico] (1)
- Bakterien (1)
- Balints-Syndrome (1)
- Ballistics (1)
- Baltic Sea (1)
- Barbed suture (1)
- Barbed suture material (1)
- Barbiturates (1)
- Barcodes (1)
- Barium-133 (1)
- Barkhof criteria (1)
- Barratt Impulsiveness Scale (1)
- Barrett-Ösophagus (1)
- Barrier (1)
- Bartak (1)
- Barthel-Index (1)
- Base composition (1)
- Basophil activation test (1)
- Batf3 (1)
- Bavarian Forest (1)
- BayPass (1)
- Bayesian approach (1)
- Bayesian inverse problems (1)
- Bayesian methods (1)
- Bcl-2 proteins (1)
- Beauveria bassiana (1)
- Becker naevus (1)
- Becker naevus syndrome (1)
- Bee abundance (1)
- Beer-lambert law (1)
- Behavior (1)
- Behavioural ecology (1)
- Behçet’s disease (1)
- Bembix (1)
- Benzefuran dioxetane (1)
- Benzefuran epoxide (1)
- Benzene (1)
- Benzimidazole (1)
- Benzimidazoles (1)
- Benzo(a)pyrene-DNA binding (1)
- Benzyne (1)
- Berberine (1)
- Berchtesgaden (1)
- Berchtesgaden NP (1)
- Berenil (1)
- Berger-Parker (1)
- Bernstein-type inequality (1)
- Berry phase (1)
- Beryllium (1)
- Bessle functions (1)
- Beta(1)-adrenergic receptor (1)
- Beta(2)-adrenergic receptor (1)
- Beta-blocker (1)
- Beta-catenin (1)
- Beta-glucocerebrosidase (1)
- Bethe–Salpeter equation (1)
- Bewegungsfixateur (1)
- Bhabha Scattering (1)
- Bi-Fidelity method (1)
- Bialowieza (1)
- Bias (1)
- Biased gene conversion (1)
- Bicyclo[1.1.0]butylcarbinyl sulfonates (1)
- Bienenverhalten (1)
- Big picture (1)
- Bilma <Region> (1)
- Bindungsaktivierung (1)
- Binge drinking (1)
- BioID (1)
- BioVaSc (1)
- Biochemical-Diagnosis (1)
- Biochemistry (1)
- Biocompatibility (1)
- Biodegradable polymer scaffolds (1)
- Biodiversity (1)
- Biogenic (1)
- Biohazard (1)
- Biological identifications (1)
- Bioluminescence (1)
- Bioluminescence imaging (1)
- Biomarke (1)
- Biomechanical Properties (1)
- Bioorganosilicon chemistry (1)
- Bioorthogonal Tag (1)
- Biophysics (1)
- Biopsy (1)
- Bioreaktor (1)
- Biostratigraphy (1)
- Biowissenschaften (1)
- Biradicals (1)
- Biradikale (1)
- Birds (1)
- Bismuth (1)
- Bisphosphonates (1)
- Bistability (1)
- Black Holes in String Theory (1)
- Black Scholes equation (1)
- Black-hole (1)
- Bland–Altman (1)
- Blattschneiderameisen (1)
- Blepharoplastik (1)
- Bloch oscillations (1)
- Blood (1)
- Blood pressure (1)
- Blood stream infection (1)
- Blood-brain-barrier (1)
- Blood–brain barrier (1)
- Bloom setting (1)
- Blue Spot Analysis (1)
- Blut (1)
- Blut-Hirn-Schranke (1)
- Blutdruck (1)
- Bocas-del-Toro (1)
- Bodenwasser (1)
- Body composition (1)
- Body schema (1)
- Body size (1)
- Bombesin ; Bombesin receptor ; Chromosomal localization (1)
- Bombus (1)
- Bombus Spp. Hymenoptera (1)
- Bombus terrestris (1)
- Bone Mineral Density (1)
- Bone chips (1)
- Bone disease (1)
- Bone graft (1)
- Bone health (1)
- Bone marrow cells (1)
- Bone marrow transplantantation (1)
- Bone regeneration (1)
- Bone tissue engineering (1)
- Bone tumor (1)
- Boolean function (1)
- Boolean tree (1)
- Bootstrap (1)
- Boranes (1)
- Bordeiella pertussis (1)
- Borylation (1)
- Borylene (1)
- Bose gas (1)
- Bose-Einstein Correlations (1)
- Bose-Einstein condensation (1)
- Bose-Fermi (1)
- Bottom-up (1)
- Bound-states (1)
- Bovis (1)
- Bowen’s disease, periungual (1)
- Braak (1)
- Bradyrhizobium (1)
- Bragg-reflection waveguide (1)
- Brahma (1)
- Brain Computer Interface (1)
- Brain atrophy (1)
- Brain cancer (1)
- Brain diseases (1)
- Brain edema (1)
- Brain endothelial cells (1)
- Brain ischemia (1)
- Brain mappins (1)
- Brain stem (1)
- Brain μ-opioid receptors (1)
- Brain-Computer Interface (BCI) (1)
- Brain-computer interface (1)
- Brain-derived neurotrophic factor (1)
- Brainstem encephalitis (1)
- Brain–computer interfaces (BCI) (1)
- Branching fractions (1)
- Brassicaceae (1)
- Brassicogethes spp. (1)
- Brazil (1)
- BrdU replication banding pattern (1)
- BrdU-Hoechst (1)
- BrdU/dT replication banding (1)
- Breast cancer (1)
- Breast cancer cells (1)
- Breath tests (1)
- Breathing (1)
- Breeding system (1)
- Broca (1)
- Brockett (1)
- Broken Hill (1)
- Brombeere (1)
- Bromodeoxyuridine labeling (1)
- Bronchopulmonary dysplasia (1)
- Brownian ratchet (1)
- Brownsche Bewegung (1)
- Brucei (1)
- Brugia Malayi (1)
- Brushite (1)
- Bruton Tyrosine Kinase (1)
- Bruton's tyrosine kinase inhibitor CC-292 (1)
- Bryophyta (1)
- Buche (1)
- Bull-Headed Demon (1)
- Bullous pemphigoid (1)
- Bumblebee (1)
- Bunnell (1)
- Buntbarsche (1)
- Burkholderia pseudomallei Mip (1)
- Burkitt lymphoma (1)
- Burkitt lymphoma (BL) (1)
- Burma (1)
- Burmese Days (1)
- Business Process Models (1)
- Butadien (1)
- By-Light Scattering (1)
- B‐cell lymphoma (1)
- B−H activation (1)
- C virus (1)
- C(-1019)G polymorphism (1)
- C-11-methionine pet (1)
- C-13 NMR (1)
- C-13-metabolic flux analysis (1)
- C-6-H (1)
- C-60 fullerene (1)
- C-C coupling (1)
- C-H activation (1)
- C-IAP1 (1)
- C-MYC PUMA (1)
- C-Myc (1)
- C-Terminus (1)
- C-elegans (1)
- C-tactile fibers (1)
- C-terminal domain (1)
- C.376A>G (p.S126G) (1)
- C1-inhibitor (1)
- C1q/TNF related protein (CTRP) (1)
- C2-toxin (1)
- C3 (1)
- C3a (1)
- C3aR (1)
- C57BL/KALWRIJ mouse (1)
- C5aR2 (1)
- C6 (1)
- C60 fullerene (1)
- C9orf72 (1)
- CA2+ channels (1)
- CA3 (1)
- CA3 pyrimidal cells (1)
- CA4 (1)
- CAD (1)
- CAD detection (1)
- CAGSSS (1)
- CAM (1)
- CAPA (1)
- CAPS (1)
- CAR T (1)
- CAR T-cell (1)
- CAR-T cells (1)
- CAR-T-cell (1)
- CARAT (1)
- CASP (1)
- CASPASE-3 (1)
- CB1 receptor antagonists (1)
- CBF (1)
- CBT (1)
- CCAP (1)
- CCD (1)
- CCD, charge-coupled device (1)
- CCDC79 (1)
- CCHamide1 (1)
- CCI (1)
- CCL2 (MCP-1) (1)
- CCL3 (1)
- CCL5 (1)
- CCN1 (1)
- CCN2 (1)
- CCR4 (1)
- CCR7 (1)
- CCS (1)
- CCl\(_4\) (1)
- CD coreceptors (1)
- CD/metabolism (1)
- CD10 (1)
- CD105 (1)
- CD105 antigen (1)
- CD11b+ myeloid cells (1)
- CD133 (1)
- CD147 (1)
- CD19 (1)
- CD20 (1)
- CD23 (1)
- CD27 (1)
- CD28 costimulation (1)
- CD28 superagonists (1)
- CD2AP (1)
- CD3/19 depletion (1)
- CD319 (1)
- CD34 antigen (1)
- CD34 selection (1)
- CD38 (1)
- CD4 (1)
- CD4 T cells (1)
- CD4(+)CD25(+) (1)
- CD4+ T cells (1)
- CD4+ T-cells (1)
- CD4+T cells (1)
- CD40 ligand (1)
- CD44 (1)
- CD46 (1)
- CD4\(^{+}\) T cells (1)
- CD4\(^{+}\) T helper cells (1)
- CD52 (1)
- CD56 (1)
- CD62L (1)
- CD70 (1)
- CD74 (1)
- CD8 T cell (1)
- CD8(+) (1)
- CD8+ T cells (1)
- CD8+T cells (1)
- CD8\(^+\) T cells (1)
- CDC14A (1)
- CDH13 (1)
- CDH13 Expression (1)
- CDH13 mRNA (1)
- CDL (1)
- CDR3 sequences (1)
- CEA (1)
- CEACAM1 (1)
- CEF (1)
- CENP-A (1)
- CERN (1)
- CERN LHC Coll (1)
- CETCH cycle (1)
- CGG repeat (1)
- CHAC1 (1)
- CHIP (1)
- CHRODIS (1)
- CIAP1 (1)
- CIB1 (1)
- CIDP (1)
- CIED malfunction; pacemaker (PM) (1)
- CIN (1)
- CIP2A (1)
- CIR aerial imagery (1)
- CIS+ (1)
- CIT (1)
- CK5 (1)
- CKD (1)
- CLAVATA3 (1)
- CLEC-2 ITAM (1)
- CLIP (1)
- CLIP-seq (1)
- CLL (1)
- CLN3 (1)
- CLRN2 (1)
- CLV3p (1)
- CMSSM Point (1)
- CMV reactivation (1)
- CMV-specific cellular immunity (1)
- CNG channel (1)
- CNS Myelination (1)
- CNS diseases (1)
- CNS imaging (1)
- CNS infection (1)
- CNS injury (1)
- CNS integrity (1)
- CNVs (1)
- CO sensing (1)
- CO2 (1)
- CO2 gas exchange (1)
- CO2-sequestration (1)
- COD movements (1)
- COH29 (1)
- COI (1)
- COMPLEX 1 (1)
- COMT VAL(158)MET polymorphism (1)
- COPD diagnosis (1)
- CORONATINE INSENSITIVE 1 (1)
- COS cell expression (1)
- COU254 (1)
- COVID 19 (1)
- COVID-19 testing (1)
- COVID‐19 vaccination (1)
- COX-2 (1)
- COX2 expression (1)
- CO\(_{2}\) exposure (1)
- CO\(_{2}\) signaling (1)
- CO‐releasing molecules (CORMs) (1)
- CP-690,550 (1)
- CPAF activation (1)
- CPF (1)
- CPFE (1)
- CPG Island (1)
- CPG binding domain (1)
- CRAC (1)
- CRH stimulation test (1)
- CRH1 (1)
- CRISPR (1)
- CRISPR Cas9 (1)
- CRISPR-Cas Systems (1)
- CRISPR-Cas system (1)
- CRISPR-Cas9 (1)
- CRISPRs (1)
- CRKL (1)
- CRLs (1)
- CRPS (1)
- CRY evolution (1)
- CS1 (1)
- CSE4, CENP-A (1)
- CSI (1)
- CT perfusion (1)
- CT, circadian time (1)
- CT-angiography (1)
- CTCAE (1)
- CTGF (1)
- CTLA-4 Antigen (1)
- CTNNB1 (1)
- CTSE (1)
- CUL4-DDB1 ubiquitin ligase (1)
- CVID (1)
- CX3CL1 (1)
- CX5461 (1)
- CXCL10 (1)
- CXCL12-abundant reticular (CAR)-cells (1)
- CXCL13 (1)
- CXCL4 (1)
- CXCL5 (1)
- CXCL7 (1)
- CXCL8 (1)
- CXCL8 (IL-8) (1)
- CXCR2 (1)
- CXCR4-targeting (1)
- CXCR4/SDF-1 (1)
- CXCR7 (1)
- CXorf44 (1)
- CYP induction (1)
- CYP inhibition (1)
- CYP11B enzymes (1)
- CYP1B1 (1)
- CYP24A1 (1)
- CYP2B6 (1)
- CYP2C9 (1)
- CYP3A4 (1)
- CYR61 (1)
- C\(_{60}\) fullerene (1)
- Ca cycling (1)
- Ca2+ (1)
- Ca2+ homeostasis (1)
- Ca2+ ion analysis (1)
- Ca2+ leak (1)
- Ca2+ oscillation (1)
- Ca2+ release activated Ca2+ channel (1)
- Ca2+i handling (1)
- CaMKII (1)
- Ca\(^{2+}\) channels (1)
- Ca\(^{2+}\) indicator (1)
- Ca\(^{2+}\)-Imaging (1)
- Ca\(_{v}\)2.2 (1)
- Cabozantinib (1)
- Caco-2 (1)
- Cadherin (CDH13) (1)
- Cadherin-13 (CDH13) (1)
- Caenorhabditis elegans (C. elegans) (1)
- Calcineurin-NFATsignaling (1)
- Calcium (1)
- Calcium Citrate (1)
- Callyspongia siphonella (1)
- Calu-3 (1)
- Canada (1)
- Canaloplasty (1)
- Cancellous bone (1)
- Cancer Cell (1)
- Cancer models (1)
- Cancer prevention (1)
- Cancer risk factors (1)
- Cancer therapeutic resistance (1)
- Candida (1)
- Candida lusitaniae (1)
- Candida sp. (1)
- Candidate Phylum Poribacteria (1)
- Canis lupus familiaris (1)
- Capicua transcriptional repressor (1)
- Capillaries (1)
- Capsaicin (1)
- Capsaicin receptor (1)
- Caputo fractional derivative (1)
- CarO (1)
- Carabidae (1)
- Carbachol-induced drinking (1)
- Carbene (1)
- Carbon (1)
- Carbon Metabolism (1)
- Carbon Monoxide (1)
- Carbon-11 (1)
- Carcinogen risk Individual susceptibili (1)
- Carcinogenic potency (1)
- Carcinoma (1)
- Carcinoma cells (1)
- Carcinomatosis (1)
- Cardiac autonomic regulation (1)
- Cardiac dysfunction| Brain natriuretic peptide (1)
- Cardiac magnetic resonance imaging (1)
- Cardiac myocyte ; Beta-Receptor ; Muscarinic receptor ; cAMP ; G-protein ; Serum (1)
- Cardiac rehabilitation (1)
- Cardiac resynchronization therapy defibrillator (1)
- Cardiac ventricles (1)
- CardioMEMS™ HF system (1)
- CardioMEMS™ HF-System (1)
- Cardiology (1)
- Cardiomyopathy (1)
- Cardiovascular (1)
- Cardiovascular Magnetic Resonance (1)
- Cardiovascular biology (1)
- Cardiovascular hospitalizations (1)
- Cardiovascular magnetic-resonance (1)
- Cardiovascular risk prediction (1)
- Cardiovascular system (1)
- Care-Arbeit (1)
- Career choice (1)
- Carleson embedding theorem (1)
- Carotid intima-media thickness (CIMT) (1)
- Carotid segment (1)
- Carotid ultrasound (1)
- Carpinus betulus (1)
- Cartilage (1)
- Cartilage regeneration (1)
- Cas9 (1)
- Case report (1)
- Case-Control Studies (1)
- Caspase (1)
- Caspase 3/7 activity (1)
- Caspase-8 activation (1)
- Cataglyphis (1)
- Cataglyphis-fortis (1)
- Catechine (1)
- Catheter Lock Solution (1)
- Catheter-related Bloodstream Infections (CRBSI) (1)
- Cauchy-Born rule (1)
- Caudate nucleus (1)
- Cav2.2 (1)
- Cavity quantum electrodynamics (1)
- Cayley graph (1)
- Cdc48 (1)
- Cdu1 (1)
- Cecropia telenitida (1)
- Celebrity Autobiography (1)
- Cell (1)
- Cell Index (1)
- Cell Motility (1)
- Cell binding (1)
- Cell death and comet assay (1)
- Cell lung canger (1)
- Cell permeability (1)
- Cell replacement therapy (1)
- Cell reprogramming (1)
- Cell signalling (1)
- Cell stainin (1)
- Cell surface (1)
- Cell surface proteomics (1)
- Cell transformation (1)
- Cell viability, (1)
- Cell-based assays (1)
- Cell-line (1)
- Cellular imaging (1)
- Cellular neuroscience (1)
- Cellular prion protein (1)
- Central complex (1)
- Central hyperactivity (1)
- Central nervous system infection (1)
- Central venous access (1)
- Central venous-pressure (1)
- Centrolenidae (1)
- Ceramide (1)
- Cerebellar nuclei (1)
- Cerebellitis (1)
- Cerebral Ischemia (1)
- Cerebral blood flow (1)
- Cerebral small vessel disease (1)
- Cerebral vasospasm (1)
- Cerebral-ischemia (1)
- Cerebrolysin (1)
- Cervical cancer (1)
- Cestoda (1)
- Cestoda Taeniidae (1)
- Cestode (1)
- ChAT (1)
- ChIP-seq (1)
- ChIP-sequencing (1)
- ChT1 (1)
- Chagas diagnosis (1)
- Chagas monitoring (1)
- Chagas real time PCR (1)
- Chains (1)
- Chambers (1)
- Channelrhodopsin-2 (1)
- Characterization and analytical techniques (1)
- Charcot-Marie-Tooth disease (1)
- Charcot-Marie-Tooth neuropathy 1A (1)
- Charcot–Marie–Tooth disease (1)
- Charcot–Marie–Tooth disease type 1A (1)
- Charged Scalar Field (1)
- Charged aerosol detector (CAD) (1)
- Charged-Particles (1)
- Charm quark (1)
- Charmonia (1)
- Checkpoints (1)
- Chemerin (1)
- Chemerin processing (1)
- Chemical carcinogenesis (1)
- Chemical composition (1)
- Chemical modification (1)
- Chemical nature (1)
- Chemicals (1)
- Chemische Ökologie (1)
- Chemistry (1)
- Chemosensory neurons (1)
- Chemotactic receptors (1)
- Chemotaxis (1)
- Cherenkov detectors (1)
- Cherenkov underwater neutrino telescope (1)
- Chernobyl (1)
- Childhood cancer survivors (1)
- Children-at-Risk (1)
- Childrens-cancer (1)
- Chile (1)
- Chimeric Antigen Receptor T cells (1)
- Chinese family (1)
- Chinese politics (1)
- Chinese state media (1)
- Chl (1)
- ChlaDUB1 (1)
- Chlamydia pneumoniae (1)
- Chlamydiales (1)
- Chlamydomonas reinhardtii (1)
- Chlorophyll fluorescence (1)
- Choice Behavior/physiology (1)
- Choline deficiency (1)
- CholinomiRs (1)
- Chondrogenesis (1)
- Chondrosarcoma (1)
- Chorioamnionitis (1)
- Christianity (1)
- Chromatin and Epigenetics (1)
- Chromatin-remodeling complexes (1)
- Chromophore Assembly (1)
- Chromophores (1)
- Chromosomal instability (1)
- Chromosome aberration (1)
- Chromosome distribution (1)
- Chromosomes (1)
- Chronic Kidney-disease (1)
- Chronic disease (1)
- Chronic heart-failure (1)
- Chronic kidney-disease (1)
- Chronic lymphoblastic leukemia (1)
- Chronic myeloid leukaemia (1)
- Chronic myeloid leukemia (1)
- Chronic neuropathic pain (1)
- Chronic obstrusive pulmonary disease (1)
- Chronic respiratory diseases (1)
- Chronic rhino‑sinusitis (1)
- Chronic stress (1)
- Chrysididae (1)
- Cigarette smoking (1)
- Cimex lectularius (1)
- Circadian rhythms and sleep (1)
- Circinella (1)
- Cis-elements (1)
- Cisterna magna (1)
- Citrus (1)
- Class II antigen blockade (1)
- Claudin2 (1)
- Clay mineralogy (1)
- ClearSight\(^®\) (1)
- Clever Hans Phenomenon (1)
- Climate Change (1)
- Climatic water balance (1)
- Clinical Genetics (1)
- Clinical manifestations (1)
- Clinical practice guidelines (1)
- Clinical prediction rule (1)
- Clinical proteomics (1)
- Clinical remission (1)
- Clinical trials (1)
- Clinical-trials (1)
- Clinically silent stroke (1)
- Clonality (1)
- Clostridioides binary toxins (1)
- Cluster-RCT (1)
- Co (1)
- Co-Crystal Structures of Chili RNA (1)
- Co-option (1)
- CoA (1)
- CoPt (1)
- Coagulation factor IX (1)
- Coahuila (1)
- Cobl domain (1)
- Cocalodinae (1)
- Cochlear duct length (1)
- Cochlear planning software (1)
- Coefficient (1)
- Coffin-Lowry syndrome (1)
- Coffin–Lowry syndrome (1)
- Cognitive (1)
- Cognitive Remediation (1)
- Cognitive Therapy (1)
- Cognitive behavior (1)
- Cognitive control (1)
- Cognitive decline (1)
- Cognitive neuroscience (1)
- Cognitive representation (1)
- Cohort study (1)
- Cold (1)
- Cold War (1)
- Coleoptera: Chrysomelidae (1)
- Collaboration (1)
- Collagen (1)
- Collagen membrane (1)
- Collective effects in quantum optics (1)
- Collicions (1)
- Colloids (1)
- Colonial volvocales chlorophyta (1)
- Colony growth (1)
- Color (1)
- Combination therapy (1)
- Combinatorial Background (1)
- Commercial preparations (1)
- Community ecology (1)
- Community-acquired methicillin-resistant Staphylococcus aureus (1)
- Comorbidities (1)
- Comorbidity survey replication (1)
- Complex (1)
- Complex medium (1)
- Complexity (1)
- Components (1)
- Compound 3k (1)
- Compressive Properties (1)
- Computational and Systems Biology (1)
- Computed axial tomography (1)
- Computer modelling (1)
- Computer science (1)
- Computer software (1)
- Computertomographie (1)
- Concealed Information Test (CIT) (1)
- Condensed matter (1)
- Conditioning evidence (1)
- Conditioning regimen (1)
- Conduct disorder (1)
- Cone-beam CT (1)
- Cone-beam computed tomography (1)
- Confidence interval (1)
- Confocal microscopy (1)
- Conformal Field Theory (1)
- Confucianism; East Asia; Traditional Values (1)
- Congo Basin (1)
- Conifers (1)
- Conjugate arc therapy (1)
- Conjugated polymers (1)
- Connective tissue (1)
- Conrad Hilton (1)
- Contaminants (1)
- Context (1)
- Contextual fear (1)
- Contrast-enhanced CT (1)
- Cooperative UAV (1)
- Coordinated Regional Climate Downscaling Experiment (CORDEX)-South Asia (1)
- Copal\(^®\) spacem (1)
- Copaxone® (1)
- Copeptin (1)
- Coptic (1)
- Copy number changes (1)
- Copy number variation (1)
- Corannulene (1)
- Coreidae (1)
- Corneal confocal microscopy (1)
- Coronary artery bypass graft (1)
- Coronary artery disease (1)
- Coronavirus Disease 2019 (1)
- Correlates (1)
- Cortex (1)
- Cortical plasticity (1)
- Corticobasal syndrome (1)
- Corticosteroids (1)
- Corynebacterium urealyticum (1)
- Cosmic-rays (1)
- Cotransporter 2 inhibition (1)
- Couch tracking (1)
- Coulomb interaction (1)
- Coumarin (1)
- Couplings (1)
- Covalent DNA binding (1)
- Covalent binding (1)
- Covalent binding index - Diethylstilbestrol (1)
- Coverage (1)
- Covid19 (1)
- Covid‐19 (1)
- Cox proportional regression analysis (1)
- CpG (1)
- CpG island hypermethylation (1)
- Cranial sutures (1)
- Cranial window (1)
- CreERT2 (1)
- Creatine Kinase (1)
- Crematogaster borneensis (1)
- Crespi effect (1)
- Critically-ill patients (1)
- Crohn disease (1)
- Crohns-disease (1)
- Crohn’s Disease (1)
- Crop seed (1)
- Cross-bridges (1)
- Cross-species analyses (1)
- CrossQuery (1)
- Cruzi (1)
- Cryoelectron Microscopy (1)
- Cryoelectron microscopy (1)
- Cryolesion (1)
- Cryptic species (1)
- Crystalloids (1)
- CsrA (1)
- CubeSat GNSS (1)
- Cultural studies (1)
- Cumulative incidence function (1)
- Curculionidae (1)
- Cuscuta (1)
- Cushing (1)
- Cushing syndrome (1)
- Cushing's (1)
- Cushing's disease (1)
- Cushings syndrome (1)
- Cutaneous hyperemia (1)
- Cutaneous leishmaniasis (1)
- Cutaneous lymphoma (1)
- Cutaneous metastatic Crohn’s disease (1)
- Cvi-0 (1)
- Cx3cr1 (1)
- Cx43 (1)
- CyaA (1)
- Cyclic AMP (1)
- Cyclic GMP (1)
- Cyclic electron transport (1)
- Cyclic nucleotides (1)
- Cyclization (1)
- Cycloaddition (1)
- Cyclobutylcarbinyl sulfonates (1)
- Cyclooxygenase-2 (1)
- Cyclophilin A (1)
- Cyclophosphamide (1)
- Cynoglossus semilaevis (1)
- CysLTR1 (1)
- Cysteine: motif (1)
- Cysteine‐Rich Domain (CRD) (1)
- Cystic-fibriosis (1)
- Cytochrome P 450 pathway (1)
- Cytochrome b5 (1)
- Cytokine GM-CSF (1)
- Cytokine receptors (1)
- Cytoskeleton (1)
- Cytosol (1)
- Cytotoxic (1)
- Cytotoxic T lymphocytes (1)
- Côte d’Ivoire (1)
- D insufficiency (1)
- D serum-levels (1)
- D-amino acid oxidase activator (1)
- D-norm (1)
- D2 receptors (1)
- D313Y genotype (1)
- D4Z4 partial deletion (1)
- D665 (1)
- DAMGO (1)
- DARPA (1)
- DAS28 (1)
- DASA-58 (1)
- DASH (1)
- DAT (1)
- DBH (1)
- DBS biomarkers (1)
- DBS programming (1)
- DBT (1)
- DC gate (1)
- DC vaccination (1)
- DCGAN (1)
- DCM genetic background (1)
- DD, constant darkness (1)
- DECAY (1)
- DEL(5Q) (1)
- DEM (1)
- DES (1)
- DETC (1)
- DEUQUA (1)
- DExD/H-Box RNA helicase (1)
- DFNB32 (1)
- DFNB68 (1)
- DFT+U (1)
- DFT-LDA (1)
- DIA-MS (1)
- DIMBOA (1)
- DIRK method (1)
- DInSAR (1)
- DLS and AFM measurements (1)
- DLX5/6 (1)
- DM2 (1)
- DMARD (1)
- DMRT1 (1)
- DNA Binding (1)
- DNA Breaks (1)
- DNA Damage Repair (1)
- DNA adduct . Repair endonuclease (1)
- DNA barcodes (1)
- DNA binching (1)
- DNA catalysis (1)
- DNA complex (1)
- DNA damage repair (1)
- DNA damage response (1)
- DNA double strand breaks (1)
- DNA double-strand break (1)
- DNA electronic transport (1)
- DNA electrophoresis (1)
- DNA fingerprinting (1)
- DNA fragments (1)
- DNA glycosation (1)
- DNA hybridization (1)
- DNA hypermethylation (1)
- DNA immunolocalization (1)
- DNA lang range mapping (1)
- DNA mediated gene transfer (1)
- DNA metabarcoding (1)
- DNA metabolism (1)
- DNA methylation dynamics (1)
- DNA methylferase homolog (1)
- DNA methyltransferase gene (1)
- DNA methyltransferases (1)
- DNA nanotechnology (1)
- DNA origami (1)
- DNA recognition (1)
- DNA recombination (1)
- DNA repair defect (1)
- DNA repair protraction (1)
- DNA repeat expansion (1)
- DNA replication initiation (1)
- DNA sensing (1)
- DNA sequence (1)
- DNA sequences (1)
- DNA sequencing (1)
- DNA structures (1)
- DNA transfection (1)
- DNA traps (1)
- DNA vaccination (1)
- DNA weight (1)
- DNA-based species delimitation (1)
- DNA-binding (1)
- DNA-binding domain (1)
- DNA-binding vesicles (1)
- DNA-damage checkpoint (1)
- DNA-encapsulated silver nanoclusters (1)
- DNA-encoded library synthesis (1)
- DNA-repair genes (1)
- DNA-tagged amines (1)
- DNA/RNA binding (1)
- DNMT3A (1)
- DNMT3B (1)
- DNS-Reparatur (1)
- DOACs (1)
- DOPA-responsive-dystonia (1)
- DOT1 (1)
- DOT1B (1)
- DOTA-EB-TATE (1)
- DPF3a (1)
- DPP III enzyme (1)
- DRD1 (1)
- DRD2 (1)
- DRD4 (1)
- DSA (1)
- DSB damage (1)
- DSB focus substructure (1)
- DSC (1)
- DSC2 (1)
- DSM (1)
- DSM-5 (1)
- DSM-IV (1)
- DSM-IV disorders (1)
- DT40 cells (1)
- DTI (1)
- DUB inhibitor (1)
- DWI (1)
- DYNC1I1 (1)
- DaTscan (1)
- Damage (1)
- Danio-rerio (1)
- Danish hernia database (1)
- Dara-KDT-P(A)CE (1)
- Dark Factor of Personality (1)
- Dark Matter (1)
- Dark matter (1)
- Dark-matter (1)
- Dark-matter production (1)
- Dasycladales chlorophyta (1)
- Data Fusion (1)
- Data acquisition (1)
- Database searching (1)
- Dauer formation (1)
- Davis gun (1)
- De-novo (1)
- DecaWave (1)
- Decay sequence (1)
- Decays (1)
- Deep Inelastic-scattering (1)
- DeepSqueak (1)
- Deficit/hyperactivity disorder (1)
- Defined burkitts lymphoma (1)
- Deflazacort (1)
- Delayed cerebral infarction (1)
- Delayed ischemic neurological deficit (1)
- Delayed snowmelt (1)
- Delbruck Scattering (1)
- Deletion (1)
- Deletion analysis (1)
- Deliberate practice (1)
- Delphi procedure (1)
- Delta Repertoire (1)
- Democracy Matrix (1)
- Democratic People's Republic of Korea (1)
- Demyelinating peripheral neuropathy (1)
- Dendritic Cells (1)
- Dendritic cell tumor (1)
- Denoising (1)
- Densities (1)
- Densovirus (1)
- Dentate granule cells (1)
- Dentistry (1)
- Deoxyribozyme (1)
- Dependence (1)
- Depression treatment (1)
- Depressive symptomatology (1)
- Der Granatapfelbaum (1)
- Der p 23 (1)
- Dermatologie (1)
- Desert ant navigation (1)
- Design patterns (1)
- Desmoplakin (1)
- Desmoplastic fibroma (1)
- Deterioration (1)
- Deutsche Forschungsgemeinschaft (1)
- Developmental biology (1)
- Devic syndrome (1)
- Devic’s syndrome (1)
- Dextran sulphate (1)
- Diabetes (1)
- Diabetes history (1)
- Diabetic nephropathies (1)
- Diabetic polyneuropathy (1)
- Diabetic-nephropathy (1)
- Diagnosis prediction (1)
- Diagnostic approach (1)
- Diagnostic radiopharmaceuticals (1)
- Dialogue Board (1)
- Diaphragmatic breathing (1)
- Diarrhea (1)
- Diastocic Dysfunction (1)
- Diborane (1)
- Diboryne (1)
- Dichte (1)
- Dickblattgewächse (1)
- Dickkopf proteins (1)
- Dictyostelium discoideum (1)
- Dictyota (1)
- Dictyotaceae (1)
- Dicyclohexylcarbodiimid (1)
- Diels–Alder reaction (1)
- Dietary process-related contaminants (1)
- Differential Cross-Sections (1)
- Differential GPS (DGPS) (1)
- Differential RNA-sequencing (1)
- Differentiation (1)
- Diffusion tensor imaging (1)
- Digital platforms (1)
- Dihydroboranes (1)
- Diisononyl phthalate (1)
- Diktat (1)
- Dilated Cardiomyopathy with Ataxia (1)
- Dimers (1)
- Dionaea-muscipula ellis (1)
- Dioncophyllaceae (1)
- Dioncophyllaceae leaves (1)
- Dioscorea (1)
- Dipeptidyl-peptidase IV inhibitors (1)
- Diplopia Internuclear ophthalmoplegia (INO) (1)
- Dirac points (1)
- Direct care workers (1)
- Directed Flight (1)
- Disaster response (1)
- Discovery (1)
- Discrete-to-continuum limits (1)
- Disease gene prioritization (1)
- Disease genetics (1)
- Disease network (1)
- Disease prevalence (1)
- Disease progression (1)
- Disease severity (1)
- Disease-modifying therapies (1)
- Disorders (1)
- Distal biceps tendon repair (1)
- Distal outflow trac (1)
- Distinct (1)
- Distress (1)
- Distributed Control (1)
- Diversity (1)
- Division (1)
- Dixon (1)
- Diät (1)
- Dmrt1bY (1)
- Dociostaurus maroccanus (1)
- Doctor (1)
- Domain-specific approach (1)
- Dongting Lake (1)
- Donor lymphocytes (1)
- Donor−acceptor dyads (1)
- Dopaminergic PAM cluster neurons (1)
- Dorsolateral prefrontal cortex (1)
- Dorylinae (1)
- Dose reduction (1)
- Dosimetry (1)
- Double hemorrhage model (1)
- Double sensitization (1)
- Double-Beta Decay (1)
- Double-blind (1)
- Down-regulation (1)
- Doxorubicin (1)
- Draize eye test (1)
- Drinfel’d twists (1)
- Drosha (1)
- Drosophila Antennal Lobe (1)
- Drosophila melanogaster motoneuron (1)
- Drosophila model (1)
- Drosophilia (1)
- Drought (1)
- Drug Therapy, Combination (1)
- Drug allergy (1)
- Drug delivery (1)
- Drug discovery (1)
- Drug metabolism (1)
- Drug reaction (1)
- Drug-free remission (1)
- Dsg2 (1)
- Dual 3'seq (1)
- Dual-PAM-100 (1)
- Duchenne dystrphy (1)
- Dufours gland (1)
- Dunce isoforms (1)
- Durchflusscytometrie (1)
- Dynamic Causal Modeling (1)
- Dynamic stopping (1)
- Dynamical Supersymmetry Breaking (1)
- Dyson orbitals (1)
- Dystonia (1)
- Dünndarm (1)
- E(+)E(-) collicions (1)
- E-H bond activation (1)
- E-cadherin (1)
- E. coli (1)
- E. coli atp operon (1)
- E. coli hemolysin (1)
- E. coli virulence (1)
- E/T ratio (1)
- E/e’ (1)
- E1 (1)
- E2 conjugating enzyme (1)
- E3 14.7-kilodalton protein (1)
- E3 enzyme (1)
- E3 ligase (1)
- E3 ligating enzyme (1)
- E3 ubiquitin ligase (1)
- EAHP/SH bone marrow workshop (1)
- EANM (1)
- EANM dosage card (1)
- EAU guidelines (1)
- EBER in situ hybridization (1)
- EBM (1)
- EBRT (1)
- ECG (1)
- ECG-recording (1)
- ECM coating (1)
- ECM remodeling (1)
- ECMO (1)
- ECMO indication (1)
- ECORN-CF Projekt (1)
- ED2 (1)
- EDS (1)
- EDX spectra (1)
- EEA (1)
- EEG data (1)
- EEG frequency band analysis (1)
- EEG preprocessing (1)
- EEG processing (1)
- EEG/ERP (1)
- EEOS (1)
- EGF (1)
- EGF receptor (1)
- EGR1 (1)
- EHS classification (1)
- EHT (1)
- EHT1864 (1)
- EIP on AHA (1)
- EJMA-D-19-00287 (1)
- EMMA (1)
- EMMPRIN (1)
- ENV (1)
- ENVISAT ASAR WSM (1)
- EO data (1)
- EORTC-BN20 (1)
- EORTC-QLQ-C15-PAL (1)
- EP Procedures (1)
- EPM (1)
- EPR (1)
- EQ-5D (1)
- ER Ca2+ imaging (1)
- ER Ca2+ store (1)
- ER signaling (1)
- ER stress (1)
- ER-Stress (1)
- ERBB receptors (1)
- ERCC1-XPF (1)
- ERCC4 (1)
- ERG (1)
- ERI (1)
- ERK map kinease (1)
- ERK signaling (1)
- ERK signaling cascade (1)
- ERM proteins (1)
- ERP-BCI (1)
- ERPS (1)
- ERPs (1)
- ERPs (Event-Related Potentials) (1)
- ERT (1)
- ESAT‐6‐like secretion system (1)
- ESBL (1)
- ESC (1)
- ESCAlife (1)
- ESM (1)
- ESPED (1)
- ESTARFM (1)
- ESTARFM framework (1)
- ETR (1)
- EU (1)
- EU member states (1)
- EU-RHAB registry (1)
- EULAR guidelines (1)
- EUROASPIRE survey (1)
- EU‐RHAB Registry (1)
- EVER1 (1)
- EVER2 (1)
- EVI (1)
- EVT (1)
- EVs (1)
- EWAS (1)
- EZH1 (1)
- EZH2 differentiation trichostatin (1)
- Early posterior negativity (1)
- Eating disorder (1)
- Eccentricities (1)
- Ecological Networks (1)
- Ecological momentary assessment (1)
- Ecological networks (1)
- Ecologically important traits (1)
- Ecosystem ecology (1)
- Ecosystem services (1)
- Ectopic bone formation (1)
- Edema (1)
- Edema formation (1)
- Edmund Husserl (1)
- Effective dose (1)
- Effectors in plant pathology (1)
- Efflux transport (1)
- Egfr (1)
- Ehlers-Danlos syndrome (1)
- Eigenvectors (1)
- Einfluss (1)
- El Escorial (1)
- El Niño (1)
- Elbow (1)
- Elbow joint (1)
- Elderly patients (1)
- Elective cesarean-section (1)
- Electric Field (1)
- Electrical breakdown (1)
- Electrical impedance tomography (1)
- Electrochemistry (1)
- Electroencephalography (1)
- Electromagnetic signals (1)
- Electron (1)
- Electron Microscopy (1)
- Electron demand in ditosylates (1)
- Electron transfer (1)
- Electrophiles (1)
- Electrophysiology (1)
- Electroweak Measurements (1)
- Electroweak Phase-Transition (1)
- Elektronisches Publizieren (1)
- Elissen-Palm flux (1)
- Elite Rowers (1)
- Ellenbogengelenk (1)
- Embolism resistance (1)
- Embryo (1)
- Embryonic induction (1)
- Embryonic stem cell (1)
- Embryos (1)
- Emergence (1)
- Emery-Dreifuss muscular dystrophy (1)
- Emission (1)
- Emodin (1)
- Emotion (1)
- Emotional behavior (1)
- Emotional expression (1)
- Emotional labor (1)
- Emotionality (1)
- Emotionsregulation (1)
- EndoVAC and small bowel (1)
- Endogenous genotoxicity (1)
- Endogenous opioids (1)
- Endoplasmic-Reticulum Stress (1)
- Endothelial growth-factor (1)
- Endothelzelle (1)
- Energies (1)
- Energy depletion (1)
- Energy transfer (1)
- England (1)
- English version (1)
- Enhancer (1)
- Enhancer elements (1)
- Enoxaparin (1)
- Enrichment analysis (1)
- Enrique Gaspar y Rimbau (1)
- Enteric nervous system (1)
- Enteric neuropathies (1)
- Enterica serovar typhimurium (1)
- Enterococcus faecalis (1)
- Enterococcus faecium (1)
- Enterovirus (1)
- Entomology (1)
- Entwicklung (1)
- Environmental enrichment (1)
- Environmental impact (1)
- Environmental isolate (1)
- Envisat (1)
- Enzyme Regulation (1)
- Enzyme immunoassay (1)
- Enzyme kinetics (1)
- Enzyme metabolism (1)
- Enzyme regulation (1)
- Enzyme-Linked Immunospot assay (ELISPOT) (1)
- Enzyme‐Linked Immunosorbent Assay (1)
- EpCAM (1)
- Epicardium-derived cells (1)
- Epichloë spp. (1)
- Epidemiological study (1)
- Epidermal growth-factor (1)
- Epidermaler Wachstumsfaktor-Rezeptor (1)
- Epidermis (1)
- Epidural Analgesia (1)
- Epigenesis (1)
- Epigenetic (1)
- Epigenetic regulation (1)
- Epigenetics (1)
- Epilepsy (1)
- Episkin (1)
- Epitaxy (1)
- Eplerenone (1)
- Epoxide hydrolase (1)
- Epstein-Barr virus (1)
- Epstein-Barr virus-induced gene 2 (1)
- Epstein-Barr-virus (1)
- Equipment (1)
- Erbendorf (1)
- Erigone atra (1)
- Eriodictyon californicum (1)
- Erwachsener (1)
- Erwinia amylovora (1)
- EsaA (1)
- Escberichia coli (1)
- Escherichia coli AlkA (1)
- Escherichia coli K1 (1)
- Escherichia coli infections (1)
- Escherichia coli-Hfq (1)
- Escherichia coli-derived recombinant human bone morphogenetic protein-2 (1)
- Escherichia-coli K-12 (1)
- Ester (1)
- Estivation (1)
- Estrone (1)
- Ethanol (1)
- Ethionine (1)
- Ethiopia (1)
- Eukaryoten (1)
- Eukaryotic cell (1)
- Eulen <Schmetterlinge> (1)
- Euler system (1)
- Euler–Bernoulli damped beam (1)
- Eulophidae (1)
- EuroQol Five Dimension Five Level Scale (EQ-5D-5L) (1)
- European Innovation Partnership on Active and Healthy Ageing (1)
- European Property Law (1)
- European Society (1)
- European Spanish (1)
- European countries (1)
- European experience (1)
- European experts (1)
- European foulbrood (1)
- European group (1)
- European orchard bee (Osmia cornuta) (1)
- Evans syndrome (1)
- Event (1)
- Event builder (1)
- Events GW150914 (1)
- Evoked potentials (1)
- Evolutionary developmental biology (1)
- Evolutionary emergence (1)
- Exacerbation (1)
- Examensklausur (1)
- Examination (1)
- Excision (1)
- Excited states (1)
- Exciton-polariton condensate (1)
- Excitons (1)
- Exercise (1)
- Exercise intervention (1)
- Exons (1)
- Exosome (1)
- Exotic mesons (1)
- Exotics (1)
- Expected MOS (1)
- Expected QoE (1)
- Experimental brain trauma (1)
- Experimental intracerebral hemorrhage (1)
- Experimental stroke (1)
- Experimental study (1)
- Expert chess players (1)
- Explorative analyses (1)
- Exposure therapy (1)
- Expresses genes (1)
- Expression of mood states (1)
- Extended field irradiation (1)
- Extensions of Higgs sector (1)
- External exposure assessment (1)
- Extra-anatomical (1)
- Extracellular domain (1)
- Extracellular matrix (1)
- Extracellular volume (1)
- Extracorporeal Membrane Oxygenation (1)
- Extracorporeal membrane oxygenation (1)
- Extramedullary disease (1)
- Extraocular eye muscles (1)
- Extreme flows (1)
- Exziton (1)
- Eye Movement Modeling Examples (1)
- Eye Movements/physiology (1)
- Eye development (1)
- Eye gaze (1)
- Eyjafjallajökull 2010 (1)
- E−X bond activation (1)
- F-18-FDG PET (1)
- F-18-FDG PET/CT (1)
- F-19 MRI (1)
- F1 (1)
- FADD (1)
- FADS (1)
- FAIR (1)
- FAM104A (1)
- FAM104B (1)
- FANCA (1)
- FANCD2 (1)
- FANCM (1)
- FANCP (1)
- FAP (1)
- FAPI PET/CT (1)
- FARS1 (1)
- FAS (1)
- FBXW7 (1)
- FCS (1)
- FDG-PET (1)
- FDG-PET/MRI (1)
- FDM (1)
- FE (1)
- FFPE (1)
- FGF (1)
- FGF/FGFR signalling (1)
- FGF21 (1)
- FGFR signaling (1)
- FGFR-inhibitors (1)
- FIB-SEM (1)
- FINCA (1)
- FISH-CLEM (1)
- FL spectroscopy (1)
- FLIMbee (1)
- FLJ14775 (1)
- FLJ20434 (1)
- FLS2 receptor (1)
- FLT-PET (1)
- FMR1 (1)
- FMR2 (1)
- FNIRS (1)
- FOLFIRI (1)
- FOLFOX (1)
- FOSMN (1)
- FP-CIT SPECT (1)
- FPG protein (1)
- FRET (1)
- FRET sensors (1)
- FRG (1)
- FRG calculations (1)
- FRN (1)
- FT-IR spectroscopy (1)
- FTY720 (1)
- FTY720-P (1)
- FV45 (1)
- FWGE (1)
- FXII (1)
- FXIIa inhibitor rHA-Infestin (1)
- FXR1 (1)
- FXR2 (1)
- Fabaceae (1)
- Fabry Disease (FD) (1)
- Fabry cardiomyopathy (1)
- Fabry patient (1)
- Faces and scenes (1)
- Facial Nerve Transection (1)
- Facial expression (1)
- Facial nerve palsy (1)
- Factor gene PRPF31 (1)
- Factor messenger-RNA (1)
- Factor sigma(B) (1)
- Factor-alpha (1)
- Fagus orientalis (1)
- Fak regulation (1)
- Faktor (1)
- False Vacuum (1)
- False positive reactions (1)
- Familial Alzheimers-disease (1)
- Familial Beckwith-Wiedemann syndrome (1)
- Family (1)
- Family Investigation of Nephropathy and Diabetes (1)
- Fanconi Anemia (1)
- Fanconi anaemia (1)
- Fanconi anemia (1)
- Fanconi-Anämie (1)
- Fanconi-anemia subtype (1)
- FasL (1)
- Fascia transversalis (1)
- Fatigue (1)
- Fats (1)
- Fatty acids (1)
- Fbw7 (1)
- Fc-receptor (1)
- FcγR receptor (1)
- FeS proteins (1)
- Fear (1)
- Fear conditioning (1)
- Fehleridentifikation (1)
- Female patients (1)
- Feminisation (1)
- Femoral vein (1)
- Femtosecond Mid-Infrared Study (1)
- Fermi liquid (1)
- Fernerkundung (1)
- Ferrite (1)
- Fetal brain development (1)
- Fettgehalt (1)
- Fettsucht (1)
- Fgf-signalling (1)
- Fibrin glue (1)
- Fibroblast Growth Factor (1)
- Fibroblast Growth Factor-21 (1)
- Fibromyalgia (1)
- Fibromyalgie (1)
- Ficaria ambigua (1)
- Ficaria calthifolia (1)
- Ficaria verna (1)
- Field sting (1)
- Fiels-effect transistors (1)
- Fifth Dynasty (1)
- Filial piety/xiao (1)
- Fimbria (1)
- Fimbriae (1)
- FinO family (1)
- First G-APD Cherenkov Telescope (1)
- Fische (1)
- Fischer 344 rats (1)
- Fisher Z-score transformation (1)
- Fitbit Sense (1)
- Fks1 (1)
- Flagellum (1)
- Flash relaxation kinetics (1)
- Flavonoids (1)
- Flavor Violation (1)
- Flavour changing neutral currents (1)
- Flexor tendon repair (1)
- Flowering (1)
- Flowering plants (1)
- Flowers (1)
- Flt3L (1)
- Fludarabine (1)
- Fludarabine-treosulfan (FT) (1)
- FluidFM technology (1)
- Fluorescein angiography (1)
- Fluorescence Microscopy (1)
- Fluorescence and Crosslinking (1)
- Fluorescence in situ hybridization (1)
- Fluorescence microscopy (1)
- Fluorescence resonance energy transfer (1)
- Fluoreszenzresonanz-Energietransfer (1)
- Fluoro(perfluoroalkyl) phosphoranes (1)
- Fluorogenic RNA Aptamers (1)
- Fluorouracil (1)
- Flussufer (1)
- Foamy virus (1)
- Foc protein (1)
- Follicular lymphoma (1)
- Follow-up (1)
- Fontan’s Operation (1)
- Food Carvings Questionnaire (1)
- Food Cravings Questionnaires (1)
- Food craving (1)
- Foragers (1)
- Foraging behaviour (1)
- Forces (1)
- Forecasting (1)
- Forensische Anthropologie (1)
- Forensische Osteologie (1)
- Forests (1)
- FormCalc8 (1)
- Fortran code (1)
- Fourier-transform spectroscopy (1)
- Fourthcorner analysis (1)
- FoxO3 (1)
- FoxP3 Expression (1)
- FoxQ2 (1)
- Frabin/Fgd4 (1)
- Fractional cover analysis (1)
- Fragmentation (1)
- Fragmentierung (1)
- Frame-based (1)
- Frame-less (1)
- Framingham (1)
- Fraser syndrome (1)
- Fraxinus excelsior (1)
- Freeze-etching (1)
- Fremdsprachenlernen (1)
- Fremdsprachenunterricht (1)
- French-Canadian patients (1)
- Frequency (1)
- Frequency-response areas (1)
- Fresh Freeze Plasma (1)
- Friedreich’s ataxia (1)
- Frontal cortex (1)
- Fruits (1)
- Frustrated Lewis Pairs (1)
- Ftsz (1)
- Fulgurite (1)
- Full body ownership illusion (1)
- Function knowledge (1)
- Functional diversity (1)
- Functional magnetic resonance imaging (1)
- Functional modules (1)
- Functional nucleic acids (1)
- Functionalization (1)
- Fungal (1)
- Fungal cell-walls (1)
- Fungal host response (1)
- Fungal traits (1)
- Fungiplex Candida Auris (1)
- Fungus (1)
- Fusarium fujikuroi (1)
- Förster Resonance Energy Transfer (1)
- Förster resonance energy transfer (1)
- G Protein (1)
- G protein coupled receptor (GPCR) (1)
- G protein coupled receptors (1)
- G protein-coupled receptor (1)
- G-2 (1)
- G-protein coupled receptor (1)
- G-protein coupled receptors (1)
- G-protein-coupled receptor (1)
- G-protein-coupled receptors (1)
- G-quadruplex motifs (1)
- G3BP (1)
- GAAS (1)
- GABA(A) receptors (1)
- GABA-A receptor (1)
- GABA-receptor complex (1)
- GABAA (1)
- GABAB receptor agonists (1)
- GABA\(_A\) (1)
- GABA\(_{A}\) (1)
- GABA\(_{A}\) receptor (1)
- GABA\(_{A}\) receptors (1)
- GABA\(_{B}\) (1)
- GABAergic neurons (1)
- GABBR1 (1)
- GABP (1)
- GAD1 (1)
- GAG (1)
- GAMMA (1)
- GAN (1)
- GAP (1)
- GATA-3 (1)
- GA\(^2\)LEN (1)
- GBM (1)
- GBR (1)
- GBS (1)
- GC-Content (1)
- GCA (1)
- GCC (1)
- GCH1 (1)
- GDF-5 (1)
- GDNF (1)
- GDNF5 (1)
- GEDI (1)
- GFAP-astrocytopathies (1)
- GFP (1)
- GH response (1)
- GHQ-28 (1)
- GI (1)
- GI-101A tumor xenografts (1)
- GIS-analysis (1)
- GIST (1)
- GLA mutation (1)
- GLA protein UCMGP (1)
- GLDN variant (1)
- GLP-1 (1)
- GLUT1 (1)
- GLUT4 (1)
- GLUT5 (1)
- GLUTs (1)
- GLV-1 h153 (1)
- GM (1)
- GMP (1)
- GMPcGMP-dependent protein kinase I (1)
- GMSB model (1)
- GNA11 (1)
- GNAQ (1)
- GNSS/INS integrated navigation (1)
- GO1 (1)
- GOLD (1)
- GP41 cytoplasmic tail (1)
- GPCRs (1)
- GPI-anchor (1)
- GPR54 (1)
- GPS (1)
- GPS Reciever (1)
- GPS tracking (1)
- GPVI shedding (1)
- GPX4 (1)
- GRAID (1)
- GRAPPA (1)
- GRN (1)
- GRO alpha (1)
- GRP78 (1)
- GSH (1)
- GSK-3β (1)
- GSK3 (1)
- GSTP1 (1)
- GSV (1)
- GTL2 (1)
- GUT (1)
- GUT-directed hypnotherapy (1)
- GVL (1)
- Ga-68 (1)
- GaAs (1)
- GaAsSb (1)
- GaSb/AlAsSb (1)
- GagPol fusion protein (1)
- Galactic Ridge (1)
- Galactic sources (1)
- Galactosidase-A gene (1)
- Galectin-1 (1)
- Gallium (1)
- Gamma-convergence (1)
- Gamma-ray bursts (1)
- Gamsberg (1)
- Ganglia (1)
- Ganglia (rat) (1)
- GapN (1)
- Garcinia biflavonoids (1)
- Garmin Fenix 6 Pro (1)
- Gaseous detectors (1)
- Gastric carcinogenesis (1)
- Gastroenteritis (1)
- Gastrointestinal (1)
- Gauge bosons (1)
- Gauge-dependent Quantity (1)
- Gaussia princeps luciferase (GpL) (1)
- Gaze behavior (1)
- Gaze perception (1)
- Gb3 and lyso-Gb3 biomarkers (1)
- Gecko (1)
- Gedächtnis (1)
- Gefäßpflanzen (1)
- Geitonogamy (1)
- Gelenkinstabilität (1)
- Gender (1)
- Gene Regulation (1)
- Gene Transfer (1)
- Gene duplication (1)
- Gene expression (1)
- Gene expression analysis (1)
- Gene expression profiling (1)
- Gene expression vectors (1)
- Gene mapping (1)
- Gene sets (1)
- Gene silencing (1)
- Gene therapy (1)
- Gene transfer (1)
- Gene-transfer (1)
- General anaesthesia (1)
- General-population (1)
- Generation (1)
- Generic questionnaire (1)
- Genetic (1)
- Genetic causes of cancer (1)
- Genetic instability (1)
- Genetics (1)
- Genitoanal region (1)
- Genom (1)
- Genom / Genkartierung / Genanalyse (1)
- Genome analysis (1)
- Genome assembly (1)
- Genome comparison (1)
- Genome evolution (1)
- Genome re-annotation (1)
- Genome wide analysis (1)
- Genome-wide association studies (1)
- Genomic profile (1)
- Genomics (1)
- Genomics data sets (1)
- Genotype (1)
- Genotype-phenotype association (1)
- Genotype–phenotype correlations (1)
- Gentransfer (1)
- Georgre Orwell (1)
- Geriatric care (1)
- Geriatrics (1)
- German Research Foundation (1)
- German Stroke Registers Study Group (1)
- German healthcare system (1)
- German population (1)
- German translation (1)
- German/French/Italian (1)
- Germanium (1)
- Germanium telluride (1)
- Germination (1)
- Germinative cell (1)
- Germline (1)
- Germylenes (1)
- Gerontologie (1)
- Geruch (1)
- Geschlechtsbestimmung (1)
- Getz Ice Shelf (1)
- Gewebe (1)
- Ghana (1)
- Giant cell arteritis (GCA (1)
- GibS (1)
- Gibbs activation energy (1)
- Gifsy-1 (1)
- Gimbaled tracking (1)
- Gland (1)
- Gleason score (1)
- Gletscher (1)
- Glial fibrillary acidic protein (1)
- Glioblastom (1)
- Glioblastoma cell line (1)
- Glioblastoma multiforme (1)
- Glioblastomas (1)
- Glioma stem cells (1)
- GlobALS (1)
- Global Ecosystem Dynamics Investigation (1)
- Global Navigation Satellite System (GNSS) (1)
- Global Positioning System (GPS) (1)
- Globotriaosylceramide (1)
- Glomerular filtration (1)
- Glomerular-filtration-rate (1)
- Glucagon (1)
- Glucose metabolism (1)
- Glucose transport (1)
- Glucose uptake (1)
- Glucosetransportproteine (1)
- Glucosyltransferase (1)
- Gluon (1)
- Gluon Fusion (1)
- Glut1DS (1)
- Glutamate-induced excitotoxicity (1)
- Glutamate-receptor (1)
- Glutamatergic synapses (1)
- Glutamic-acid decarboxylase anxiety (1)
- Glutathione Stransferase (1)
- GlyR receptors (1)
- GlyRs (1)
- Glycaemic control (1)
- Glycosyltransferase (1)
- Goldbrasse (1)
- Golgi apparatus (1)
- Good Practices (1)
- Good-or-Better (GoB) (1)
- Google Earth (1)
- Google Earth Engine (GEE) (1)
- Government research funding (1)
- Gradient boosted trees (GBT) (1)
- Gradients (1)
- Graft versus Tumor (1)
- Graft-versus-host disease (1)
- Graft-versus-leukemia (1)
- Gram points (1)
- Gram’s law (1)
- Granular layer (1)
- Graph eigenvalues (1)
- Graph products (1)
- Graphene nanoribbons (1)
- Graphnullity (1)
- Graptolithoidea (1)
- Grasses (1)
- Graves disease (1)
- Grave’s disease (1)
- Gravitons (1)
- Graßmannians (1)
- Grebe dysplasia (1)
- Green's function (1)
- Greenland (1)
- Greenland ice sheet (1)
- Green’s functions (1)
- Grenzflächenaktiver Stoff (1)
- Grippe (1)
- Groin infection (1)
- Group dynamics (1)
- Growth-factor receptor (1)
- Growth; BMP-2 (1)
- Gruppo-italiano (1)
- Guanylyl cyclase-A (1)
- Guideline (1)
- Guillain-Barré syndrome (1)
- Guillain-Barré-Syndrom (1)
- Guinea pig model (1)
- Guinean rain forest (1)
- Guinier-Preston zones (1)
- Göttingen (1)
- Gα\(_{i1}\), Gα\(_{i2}\) and Gα\(_{i3}\) activation (1)
- H+-atpase (1)
- H-infinity (1)
- H2A histone family member X (H2AX) (1)
- H3K27me3 (1)
- H441 (1)
- H7N9 influenza virus (1)
- HA modifiedCNF membranes (1)
- HAND (1)
- HAQ (1)
- HB-EGF (1)
- HBO (1)
- HCMV infection (1)
- HCV (1)
- HCV cure (1)
- HCV genotype 2 (1)
- HCV genotype-2 (1)
- HCV infection (1)
- HCW (1)
- HD (1)
- HDAC (1)
- HDBSCAN (1)
- HE-3 diffusion MRI (1)
- HECT (1)
- HECT Ligase (1)
- HEK cells (1)
- HEMA (1)
- HER2 (1)
- HER2 conversion (1)
- HER2 targeted therapy (1)
- HER2-low (1)
- HERV-K (1)
- HES (1)
- HEV (1)
- HEY repressors (1)
- HFmrEF (1)
- HFrEF (1)
- HGPS (1)
- HHV-6 (1)
- HHblits (1)
- HIGGS (1)
- HIIT (High intensity interval training) (1)
- HIP osteoarthritis (1)
- HIV diagnosis and management (1)
- HIV infection (1)
- HIV infections (1)
- HIV neurocognitive impairment (1)
- HIV-1 protease (1)
- HIV-1 subtype AG (1)
- HIV-1-infected patients (1)
- HIV-1-infected subjects (1)
- HIV-1; subtype C; proviral plasmid; viral replication; resistance assays; Vpu; CD317; CD4 (1)
- HIV-Infektion (1)
- HIV-infected patients (1)
- HKT1 (1)
- HLA (1)
- HLA antigens (1)
- HLA class II (1)
- HLA class ll (1)
- HLA peptidome (1)
- HLA-E matching (1)
- HLA-G gene (1)
- HMD (Head-Mounted Display) (1)
- HMDP hydroxymethylene diphosphonate (1)
- HMG-Proteine (1)
- HMGB1 (1)
- HNSC (1)
- HPLC-MS/MS method (1)
- HPLC/UPLC methods (1)
- HPLC–MS (1)
- HPc (1)
- HPβCD (1)
- HRAS (1)
- HRMS (1)
- HRQL (1)
- HRQOL (1)
- HRTEM (1)
- HRV (1)
- HSAB principle (1)
- HSTC outcome (1)
- HT-29 colon carcinoma cells (1)
- HT29 cells (1)
- HTLV-I (1)
- HTTP adaptive video streaming (1)
- HaCaT cells (1)
- Habitats (1)
- Hadron Collider (1)
- Hadron Hadron scattering (experiments) (1)
- Hadron-Hadron Scattering (1)
- Hadron-hadron interactions (1)
- Haematogenous (1)
- Haematology (1)
- Haemodialysis (1)
- Haemolysin (1)
- Haftung (1)
- Halbleiter (1)
- Halictidae (1)
- Hall effect (1)
- Halobacterium halobium (1)
- Haloferax volcanii (1)
- Halothane (1)
- Hamman's syndrome (1)
- Hans algorithm (1)
- Haploidentical (1)
- Harnwegsinfekt (1)
- Harold Garnet Callan (1)
- Hautflügler (1)
- Hautkrebs (1)
- Hautus test (1)
- Hazards (1)
- Head (1)
- Head and neck cancer (1)
- Head and neck cancers (1)
- Head-injury (1)
- Health (1)
- Health care service research (1)
- Health promotion (1)
- Health-determinants (1)
- Healthcare Cost (1)
- Healthcare Economics (1)
- Healthcare research (1)
- Hearing loss (1)
- Hearing-loss (1)
- Heart failure with preserved ejection fraction (1)
- Heart failure with reduced ejection fraction (1)
- Heart rate (1)
- Heart rate variability (1)
- Heat Hyperalgesia (1)
- Heat Wave Magnitude Index (HWMI) (1)
- Heavy-Particles (1)
- Hecke L-functions (1)
- Hecke eigenforms (1)
- Hegyi competition index (1)
- Hela Cells (1)
- Helicobacterpylori (1)
- Hemagglutination inhibition (1)
- Hematopoietic Stem (1)
- Hematopoietic cell transplant (1)
- Hematopoietic stem cell transplantation (1)
- Heme-regulated inhibitor (1)
- Hemipelvectomy (1)
- Hemodialysis-patients (1)
- Hemodynamic depression (1)
- Hemoglobin A1C (1)
- Hemolysin excretion (1)
- Hemorrhage (1)
- Hemospermia (1)
- Heparan-sulfate (1)
- Heparin (1)
- Hepatitis B Virus (1)
- Hepatitis B virus (1)
- Hepatitis B virus reactivation (1)
- Hepatitis C (1)
- Hepatitis C infection (1)
- Hepatitis E (1)
- Herbivory (1)
- Hereditary breast cancer (1)
- Herodotus (1)
- Herpes (1)
- Herpes simplex encephalitis (1)
- Herpes simplex virus (1)
- Herzthoraxchirurgie (1)
- Hesse (1)
- Heterocyclen (1)
- Heterocyclische Verbindungen (1)
- Heteroptera (1)
- Heubacillus (1)
- HeuristicsMiner algorithm (1)
- Hexadehydro-Diels-Alder (1)
- Hexahydro-difenidol (1)
- Hexahydro-difenidol analogues (1)
- Hexahydro-procyclidine (1)
- Hexbutinol (1)
- Hexocyclium/sila-hexocyclium derivatives (1)
- Hg1-xCdxTe (1)
- HgTe (1)
- HiGHmed (1)
- Hibernation (1)
- Hickman catheter (1)
- Hierarchy problem (1)
- Higgs Boson (1)
- Higgs Mass (1)
- Higgs boson decays (1)
- Higgs boson mass (1)
- Higgs boson signal (1)
- Higgs-boson (1)
- Higgy-Boson (1)
- High efficiency (1)
- High fat diet (1)
- High grade glioma (1)
- High mobility group (1)
- High performance (1)
- High-Energies (1)
- High-Frequency Ventilation (1)
- High-dose chemotherapy (1)
- High-energy jets (1)
- High-fat diet (1)
- High-jump photographs (1)
- High-performance liquid chromatography (HPLC) (1)
- High-resolution (1)
- High-spontaneous rate (1)
- High-throughput data (1)
- High-throughput screening (1)
- Higher rates (1)
- Highlights Lecture (1)
- Hill's powers (1)
- Himalaya Karakoram (1)
- Hindbrain (1)
- Hip joint (1)
- Hippocampus (1)
- Hirnhautentzündung (1)
- Hirschsprung disease liability (1)
- Histologic grade (1)
- Histone deacetylase (1)
- Histone deacetylase inhibition (1)
- Histone gamma H2AX (1)
- Hittitology (1)
- Hodgkin-lymphoma (1)
- Hoechst 33258 dye (1)
- Hoechst 33342 (1)
- Hoffa (1)
- Holliday junction reolvass (1)
- Holocene (1)
- Holography and condensed matter physics (AdS/CMT) (1)
- Holozän (1)
- Home monitoring (1)
- Homebox gene (1)
- Homeostatic plasticity (1)
- Homoarginine (1)
- Homology (1)
- Homoptera aphididae (1)
- Homotopy Continuation Method (1)
- Honey bee (1)
- Honey bees (1)
- Honey-bees (1)
- Honeybee (1)
- Hordeum vulgare (1)
- Horizontal transfer (1)
- Hormesis (1)
- Horowitz Quotient (1)
- Hospital emergency plan (1)
- Hospital water system (1)
- Hospitalisation (1)
- Host adaptation (1)
- Host cells (1)
- Host-pathogen interactions (1)
- Hotel (1)
- Htr1a (1)
- Htr2a (1)
- Htr2c (1)
- Hubbard model (1)
- Hubbard-model (1)
- Hueter interval (1)
- Human (1)
- Human CDH13 (1)
- Human Knee (1)
- Human Medial Meniscus (1)
- Human Muse Cells (1)
- Human Physiome (1)
- Human Resource Management (1)
- Human Sodium/Iodide symporter (1)
- Human and murine cancer cells (1)
- Human atrial stromal cells (1)
- Human endogenous retrovirus (1)
- Human entorhinal area (1)
- Human foamy virus bel-l transactivator; Expression in insect cells (1)
- Human genome (1)
- Human immunodefiency virus (1)
- Human lung-cancer (1)
- Human platelets (1)
- Human prefrontal cortex (1)
- Human-immunodeficiency-virus (1)
- Hunsrueck (1)
- Huntington's disease . Human cerebral cortex (1)
- Hurst Exponent (1)
- Hurwitz zeta function (1)
- Hybridisierung <Biologie> (1)
- Hybridoma (1)
- Hydraulic conductivity (1)
- Hydraulic plasticity (1)
- Hydroarylation (1)
- Hydrogen-deuterium (1)
- Hydrogen-peroxide (1)
- Hydroxymethyluracil (1)
- Hymenoptera venom (1)
- Hyperalgesia (1)
- Hypercortisolism (1)
- Hyperfine coupling constants (1)
- Hyperkalaemia (1)
- Hyperkalemia (1)
- Hyperolius viridiflavus (1)
- Hyperosmotic Stress (1)
- Hypersensitivity (1)
- Hypertonic (1)
- Hypertonic saline 7.5-percent (1)
- Hypertrophic cardiomyopathy (1)
- Hypertrophic pyloric-stenosis (1)
- Hypertrophy (1)
- Hypnales (1)
- Hypopharyngeal glands (1)
- Hypophosphatasia (1)
- Hypothetical particle physics models (1)
- Hypoxia (1)
- Hyrcanian forest (1)
- Hyrtios (1)
- Hämolysin (1)
- I-lactate (1)
- IA (1)
- IABP (1)
- IACS (1)
- IARS2 (1)
- IBA-1 (1)
- ICD (1)
- ICD-10 (1)
- ICD-CRT (1)
- ICD-coding of CKD (1)
- ICEP (1)
- ICF (1)
- ICF2 (1)
- ICL (1)
- ICM (1)
- ICM cells (1)
- ICP27 (1)
- ICP4 (1)
- ICRS (1)
- ICSI (1)
- ICT (1)
- ICU staff (1)
- ICU treatment (1)
- IDH (1)
- IDH1/2 (1)
- IDO-1 (1)
- IDSA (1)
- IENFD (1)
- IFN (1)
- IFN-gamma (1)
- IFN-γ ELISpot (1)
- IFNG (1)
- IGF-I (1)
- IGF1 (1)
- IGF2-H19 (1)
- IGFBP2 (1)
- II citrullinemia (1)
- II type-2 receptor (1)
- II-VI semiconductor (1)
- III adenylyl cyclases (1)
- III secretion (1)
- III secretion system (1)
- III–V quantum dot (1)
- III–V semiconductor devices (1)
- IL-1 beta (1)
- IL-1 blockade (1)
- IL-10 expression (1)
- IL-12 family (1)
- IL-12 production (1)
- IL-12B (1)
- IL-12p40 (1)
- IL-15 (1)
- IL-17A-inhibition (1)
- IL-1ß (1)
- IL-22 binding protein isoform (1)
- IL-3 (1)
- IL-4 antagonists (1)
- IL-4-receptor (1)
- IL-5 (1)
- IL-7 (1)
- IL12B (1)
- IL1RA (1)
- IL2 branching (1)
- IL22RA2 (1)
- IL28B (1)
- IL28B polymorphisms (1)
- IL6 (1)
- IL‐10 (1)
- IL‐1β (1)
- IMA2.1 (1)
- IMAZA (1)
- IMD (1)
- IMR-90 (1)
- IMSI (1)
- IMpACT (1)
- INR rebound (1)
- INS/LIDAR integrated navigation (1)
- IP3 (1)
- IPND criteria (1)
- IRF4 (1)
- IS education (1)
- ISBI (1)
- ISS (1)
- IT in Business (1)
- IT security (1)
- IVF-methods (1)
- IVIg (1)
- Ibrutinib (1)
- Ibuprofen (1)
- IcaR (1)
- Icecube (1)
- Icosanoid (1)
- IctP (1)
- Identifizierung (1)
- Ifn-gamma (1)
- IgD (1)
- IgE sensitazion (1)
- IgG glycosylation (1)
- IgG4 (1)
- IgM (1)
- Ighmbp2 (1)
- Ileal Crohns-disease (1)
- Ileal conduit (1)
- Ileum-Conduit (1)
- Ileum; Atrium (1)
- Illumina Human Exome Bead Chip (1)
- Image Aesthetic Assessment (1)
- Image interpretation (1)
- Image processing (1)
- ImageJ (1)
- ImageJ plugin (1)
- Images (1)
- Imaging (1)
- Imaging Air Cherenkov Telescope (1)
- Imaging pitfalls (1)
- Imd pathway (1)
- Imidates (1)
- Imidoyl halides (1)
- Immediate-type (1)
- Immune receptor signaling (1)
- Immune system (1)
- Immune tolerance (1)
- Immune-System (1)
- Immune-related adverse event (1)
- Immunization (1)
- Immunoadsorption (1)
- Immunoapheresis (1)
- Immunocompromised patient (1)
- Immunodeficiency (1)
- Immunogenicity (1)
- Immunoglobulin E (1)
- Immunohistochemistry (1)
- Immunological Self-Tolerance (1)
- Immunology (1)
- Immunopanning (1)
- Immunoprecipitation (1)
- Immunosenescence (1)
- Immunostimulatory adjuvant (1)
- Immunstimulation (1)
- Impact-Faktor (1)
- Impaired vision (1)
- Impella (1)
- Implicit and explicit reward learning (1)
- Improved survival (1)
- Impulsivity (1)
- In Situ Nick-End Labeling (1)
- In vitro contracture test (1)
- In vitro models (1)
- In vitro skin irritation testing (1)
- In vitro toxicity testing (1)
- In vivo (1)
- In vivo imaging (1)
- In vivo studies (1)
- In-Vivo (1)
- In-vivo dia lysis (1)
- InSAR height (1)
- Inactivation (1)
- Inbreeding depression (1)
- Inc (1)
- IncRNA (1)
- Incidence (1)
- Inclusion (1)
- Inclusion Rate (1)
- Incomplete contracts (1)
- Incontinentia pigmenti (1)
- IncuCyte\(^®\)S3 (1)
- India (1)
- Indian muntjac (1)
- Indirect and direct contributions to A<sub>iso</sub> (1)
- Indirekte Abwehr (1)
- Induced Pluripotent Stem Cells (1)
- Induced senescence (1)
- Inducible Clindamycin Resistance (1)
- Indus-Ganges-Brahmaputra-Meghna (1)
- Infarct Zone (1)
- Infection (1)
- Infection control (1)
- Infectious Diseases (1)
- Infectious complications (1)
- Inferior Vena Cava (1)
- Inferior colliculus (1)
- Inferior vena cava (1)
- Inflammatio (1)
- Inflammatory bowel disease (1)
- Inflammatory diseases (1)
- Inflammatory pain (1)
- Infliximab (1)
- Influence of excitation classes (1)
- Influenza (1)
- Influenza vaccination (1)
- Influenzae type B (1)
- Information (1)
- Information Integration Theory (1)
- Inhalation (1)
- Inhibition (1)
- Inhibitory glycine receptor (1)
- Injuries (1)
- Inner hair cell (1)
- Innervation (1)
- Inoculum production (1)
- Insect flight (1)
- Insect hosts (1)
- Insect pests (1)
- Insect symbiois (1)
- Insekt (1)
- Insensitivity (1)
- Instability (1)
- Instructors (1)
- Insulating thin films (1)
- Insulator surfaces (1)
- Insulin Degrading Enzyme (1)
- Insulin therapy (1)
- Insulinlike Growth Factor (1)
- Integrase (1)
- Integrated network analysis (1)
- Intellectual disability (1)
- IntelliCage (1)
- Intelligent Virtual Agents (1)
- Intelligent mobile system (1)
- Intensity (1)
- Inter-observer variability (1)
- InteractionSuitcase (1)
- Interactive Tree Of Life (iTOL) (1)
- Interactive Ventilatory Support (1)
- Interband cascade lasers (1)
- Interference microscopy (1)
- Interferon beta (1)
- Interferon-alpha (1)
- Interieukin-1ß (1)
- Interleukin (1)
- Interleukin 2 (1)
- Interleukin 4 (1)
- Interleukin 4 (human) (1)
- Interleukin 7 (1)
- Interleukin IL-6 (1)
- Interleukin-1 (1)
- Interleukin-10 (1)
- Interleukin-18 (1)
- Interleukin-2 (1)
- Interleukin-4 (IL-4) (1)
- Interleukin-5 (1)
- Interleukin-6-Deficient mice (1)
- Intermediate filaments (1)
- Internal transcription start site (1)
- International Physical Activity Questionnaire (1)
- International consensus diagnostic criteria for neuromyelitis optica spectrum disorders (1)
- Internet (1)
- Internet Behaviour (1)
- Internet of Things devices (1)
- Intestinal Intraepithelial Lymphocy (1)
- Intestinal pseudoobstruction (1)
- Intracellular domain (1)
- Intractable nausea and vomiting (1)
- Intravascular coagulation (1)
- Intravital imaging (1)
- Intrinsic charm (1)
- Invasion genes (1)
- Invasive Aspergillosis (1)
- Invasive fungal-infections (1)
- Inzisionale Hernie (1)
- Inzisionalhernie (1)
- IoT-driven processes (1)
- Ionizing radiation (1)
- Iowa Gambling Task (1)
- Ipilimumab (1)
- Ips typographus (1)
- Ire1 (1)
- Iron Oxide Nanoparticle (1)
- Iron-oxide (1)
- Iron-uptake (1)
- IronChip Evaluation Package (1)
- Irradiation (1)
- Irritable bowel syndrome (1)
- Ischemia (1)
- Ischemia/reperfusion (1)
- Ischemic stroke (1)
- Isheru (1)
- Islam (1)
- Islets of Langerhans (rat) (1)
- Isoenzym (1)
- Isomorphe Nukleobasen-Analoga (1)
- IsrK (1)
- J-aggregate behavior (1)
- J-aggregates (1)
- JA/JA-Ile transport protein JAT1 (1)
- JAK inhibitor (1)
- JAK2 (1)
- JAQ1 (1)
- JCV (1)
- JES (1)
- JIA (1)
- JOL reactivity (1)
- JQ1 (1)
- JR11 (1)
- JUN (1)
- Jacobian matrix (1)
- Jahn–Teller effect (1)
- Jak kinases (1)
- Janus fibers (1)
- Janus kinase (1)
- Japanese population (1)
- Jasmonate perception (1)
- Jasmonic acid (1)
- Java 3D (1)
- Jaynes-Cummings ladder (1)
- Jet physics (1)
- Jmjd6 (1)
- Johnstons organ (1)
- Joint capsule (1)
- Joint ownership (1)
- Joint pain (1)
- Josephson effect (1)
- Joubert syndrome (1)
- Journal of Nuclear Cardiology (1)
- Judaism (1)
- Jugend (1)
- Julia line (1)
- Jurkat T cells (1)
- Jurkat cells (1)
- Juvenile biventricular cardiomyopathy (1)
- Juvenile idiopathic arthritis (1)
- K + -channels (1)
- K band ranging (KBR) (1)
- K* µ+μ− (1)
- K+ channel (1)
- K+ channels (1)
- K-PG radiation (1)
- K-RAS (1)
- K-region (1)
- K279a (1)
- K2P channels (1)
- K2–K model (1)
- KAT/HAT (1)
- KATP channel (1)
- KCNK5 (1)
- KDELR2 (1)
- KEA (1)
- KFZA (1)
- KIF (1)
- KIF11 (1)
- KISS1 receptor (1)
- KISS1-54 (1)
- KM3NeT (1)
- KOOS (1)
- KRAS (1)
- KRAS biomarker signatures (1)
- KWIC (1)
- K\(_{2P}\)5.1 (1)
- Kaiser test (1)
- Kaliumkanal (1)
- Kappa-B activation (1)
- Kappa-B pathway (1)
- Karyotyp (1)
- Karyotype; chromosome banding; Desertellio elongatus; Crustacea; Isopoda; Oniscidea (1)
- Katayama fever (1)
- Keller–Segel model (1)
- Keras (1)
- Kerinokeratosis papulosa (1)
- Kerneldensity estimation (1)
- Ketogene Kost (1)
- Keuchhusten (1)
- KhpB protein (1)
- Kidney (perfused (1)
- Kidney cancer (1)
- Kidneys (1)
- Killer cell immunoglobulin-like receptors (1)
- Kinase inhibitor (1)
- Kinase pathway (1)
- Kindergarten (1)
- Kinetochore (1)
- Kinetochores (1)
- Kinetoplastea (1)
- Kinetoplastida (1)
- Kirchhoff's law (1)
- Klebsiella pneumoniae (1)
- Klima (1)
- Klotho-related molecules (1)
- Knee (1)
- Knieschmerzen (1)
- Knock-out mice (1)
- Knotless tendon repair (1)
- Koenigs function (1)
- Kohlberg (1)
- Kohlenhydrate (1)
- Kongress (1)
- Kono-S anastomosis (1)
- Konservierung (1)
- Krebskranker (1)
- Kristallographie (1)
- Kristallstruktur (1)
- Krylow matrix (1)
- Krüppel-like factor (1)
- Kunduz River Basin (1)
- L cells (1)
- L-3,4-Dihydroxyphenylalanine-induced dyskinesia (1)
- L-DOPA (1)
- L-Lactate Dehydrogenase (1)
- L. reuteri (1)
- L5178Y cells (1)
- LAALO3/SRTIO3 interfaces (1)
- LAD (1)
- LAMN (1)
- LATE DEATHS (1)
- LC-ESI/MS/MS (1)
- LC3 lipidation (1)
- LCCS11 (1)
- LCNEC (1)
- LCP (1)
- LCST (1)
- LC–HRESIMS (1)
- LC–MS/MS (1)
- LD, light:dark (1)
- LDA (1)
- LDL cholesterol (1)
- LED (1)
- LEOSS (1)
- LESA (1)
- LFA-1 (1)
- LGMDR5 (1)
- LHS (1)
- LI-rTMS (1)
- LIF (1)
- LIMP-2 (1)
- LIN-5 (1)
- LINC complexes (1)
- LINE-1 retrotransposition (1)
- LINGO-1 (1)
- LITAF (1)
- LMNA (1)
- LMNA mutations (1)
- LMX (1)
- LNCaP (1)
- LND (1)
- LNE (1)
- LOGIC study (1)
- LPHN3 (1)
- LRIG1 (1)
- LRP6 (1)
- LS-MIDA (1)
- LSD1 (1)
- LSVT-big therapy (1)
- LTB4 receptor (1)
- LTD (1)
- LTR retrotransposons (1)
- LULCC (1)
- LUMEN (1)
- LV dilatation (1)
- LV mass (1)
- LVNC (1)
- Labial glands (1)
- Labour Analgesia (1)
- Labour Pain (1)
- Lacking neurofilaments (1)
- Lactated ringers solution (1)
- Lag time (1)
- Lamarckian genetic algorithms (1)
- Lambda5-Germanate (1)
- Lamto Reserve (1)
- Land Change Modeler (1)
- Land Surface Temperature (1)
- Land Surface Temperature (LST) (1)
- Land Use/Land Cover (1)
- Land plants (1)
- Land-use change (1)
- Landau Gauge (1)
- Landau level (1)
- Landmarken (1)
- Landsat 8 (1)
- Landsat archive (1)
- Landsat-8 (1)
- Landscape ecology (1)
- Landschaft (1)
- Landwirtschaft (1)
- Langerhans cell (1)
- Langlebigkeit (1)
- Language comprehension (1)
- Lantana camara (1)
- Lao PDR (1)
- Laparoscopy (1)
- Laplace approximation (1)
- Laplace transform (1)
- Large T antigen (1)
- Large detector systems for particle and astroparticle physics (1)
- Large loop excision of the transformation zone (LLETZ) (1)
- Large multicenter ADHD (1)
- Large vessel vasculitides (LVV) (1)
- Larval development (1)
- Laser Doppler vibrometer (1)
- Late mortality (1)
- Late-effects (1)
- Latency (1)
- Lateral suboccipital craniectomy (1)
- Lateralitity (1)
- Laterality (1)
- Latimeria menadoensis (1)
- Latrophilin (1)
- Leaderless transcript (1)
- Leaf cutting ants (1)
- Learner Autonomy (1)
- Learning and memory (1)
- Learning/physiology (1)
- Leaves (1)
- Lebensalter (1)
- Lebensqualität (1)
- Lebenszyklus (1)
- Lectins (1)
- Legionella (1)
- Legionella ssp. (1)
- Legionellae (1)
- Legume crops (1)
- Legumes (1)
- LeishBASEedit (1)
- Leishmania major (1)
- Leistenhernie (1)
- Leonhard cIassification (1)
- Leonhard classification (1)
- Leptin (1)
- Lepton (1)
- Leptonic (1)
- Leptons (1)
- Lerch zeta function (1)
- Lernerautonomie (1)
- Lernkurve (1)
- Lese- und Schreibfähigkeit (1)
- Lese-Rechtschreibstörung (1)
- Lesefähigkeit (1)
- Lesen (1)
- Lesions (1)
- Leukemia Inhibitory Factor (1)
- Leukocyte/endothelium interaction (1)
- Level (1)
- Lewis acid (1)
- Lewis acid/base adducts (1)
- Lewis adducts (1)
- Lewy-like pathology (1)
- Li-Fraumeni syndrome (1)
- Lie group actions (1)
- Lie groups (1)
- Lie n-algebroids (1)
- Lieberoser Heide (1)
- Life expectancy (1)
- Lifetime spectroscopy (1)
- Ligamentum capitis femoris (1)
- Ligand <Biochemie> (1)
- Ligand effects (1)
- Light (1)
- Light Supersymmetric Particle (1)
- Light stimulation (1)
- Light-emitting diodes (1)
- Limb development (1)
- Limb girdle muscular dystrophy (LGMD) (1)
- Limb salvage (1)
- Limestone (1)
- Limit (1)
- Linagliptin (1)
- Linea alba (1)
- Lines (1)
- Lipid (1)
- Lipid metabolism (1)
- Lipom (1)
- Lipophilicity (1)
- Lipopolysaccharide (1)
- Liposomal amphotericin-B (1)
- Lipoxin (1)
- Lippert–Mataga plot (1)
- Liquid-crystalline (1)
- Listeria (1)
- Listeriolysin O (1)
- Lithium niobate (1)
- Live cells (1)
- Liver cirrhosis (1)
- Living cells (1)
- Llullaillaco Volcano (1)
- Ln-MOFs (1)
- LoRaWAN (1)
- Local governance (1)
- Local rings (1)
- Localized states (1)
- Location-based algorithms (1)
- Locked-in syndrome (1)
- Locomotion compensator (1)
- Locomotor activity (1)
- Locoregional recurrence (1)
- Locus (1)
- Locus coeruleus (1)
- Logged forests (1)
- Long COVID (1)
- Long bones (1)
- Long-range order (1)
- Long-term care (1)
- Long-term depression (1)
- Long-term follow-up (1)
- Longitudinal analysis (1)
- Longitudinally extensive transverse myelitis (1)
- Loop electrosurgical excision procedure (LEEP) (1)
- Lotka-Volterra models (1)
- Lov domain (1)
- Low risk alcohol use (1)
- Low-dose acyclovir (1)
- Low-fat diet (1)
- Lower Reference Value (1)
- Lower extremity reconstruction (1)
- LpxC inhibitors (1)
- Lu-177 (1)
- Luminescence (1)
- Lung (1)
- Lung Injury (1)
- Lung disease, (1)
- Lungenkrebs (1)
- Lutetium (1)
- Luxembourg (1)
- LyP (1)
- Lyapunov functions (1)
- Lycopersicon esculentum (1)
- Lymantria dispar (1)
- Lymph nodes (1)
- Lymph2Cx assay (1)
- Lymphocytes (1)
- Lymphoma (1)
- Lymphomas (1)
- Lynx lynx (1)
- Lysine (1)
- Lysine-specific methylase (1)
- Lysis (medicine) (1)
- Lyso-Gb3 (1)
- Lysosomal storage disease (1)
- M1/M2 macrophages (1)
- M14 carboxypeptidasses (1)
- M2 (1)
- M2 muscarinic receptors (1)
- M30 (1)
- M4 receptors (1)
- MACE (1)
- MACVIA (1)
- MAINZPouch (1)
- MALDI imaging (1)
- MAP kinase pathway (1)
- MAP1B (1)
- MAPK pathway (1)
- MAPK signaling (1)
- MAPKAPK2 (1)
- MARC effect (1)
- MAS (1)
- MASLD (1)
- MAX (1)
- MC expectation (1)
- MC program (1)
- MCC (1)
- MCL-1 (1)
- MCP1 (1)
- MCPyV (1)
- MCV-negative (1)
- MDL-28170 (1)
- MDR (1)
- MDS (1)
- MDSCs (1)
- MED-EL cochlear implant (1)
- MEDAS (1)
- MEK/ERK-signaling (1)
- MEMS IMU (1)
- MEN1 (1)
- MET receptor (1)
- METTL8 (1)
- MFM (1)
- MGL (1)
- MGMT (1)
- MGMT promoter methylation (1)
- MHC I (1)
- MHC II (1)
- MHC Klasse II (1)
- MHC class I chain-related protein (1)
- MHC molecules (1)
- MI-2/NURD complex (1)
- MIBG scintigraphy (1)
- MIC ligands (1)
- MIND estimator (1)
- MIP-1β (1)
- MIR-155 (1)
- MITE (1)
- MITF (1)
- MITF-low (1)
- MK801 (1)
- MLC tracking (1)
- MLLE domain (1)
- MLST (1)
- MMN (1)
- MMP (1)
- MMP-1 (1)
- MMP9 (1)
- MMQ cells (1)
- MNV type 3 (1)
- MOC fibers (1)
- MOD13Q1 (1)
- MODIS image (1)
- MODIS time-series (1)
- MOG-IgG (1)
- MOLLI (1)
- MOPC315.BM (1)
- MOR202 (1)
- MORN-repeat (1)
- MPACT (1)
- MPK12 (1)
- MPO (1)
- MPS (1)
- MR (1)
- MR angiography (1)
- MR guidance (1)
- MR neurography (1)
- MRI reporter (1)
- MRI spectroscopy (1)
- MRONJ (1)
- MRSA - methicillin-resistant Staphylococcus aureus (1)
- MS-18 (1)
- MSC 11M35 (1)
- MSC: 14M15 (1)
- MSC: 49M37 (1)
- MSC: 53C22 (1)
- MSC: 53C35 (1)
- MSC: 65K05 (1)
- MSC: 90C30 (1)
- MSC: 90C40 (1)
- MSCI (1)
- MSCT (1)
- MSIS (1)
- MSSM (1)
- MSSS (1)
- MTB (1)
- MTCH2 (1)
- MTH1 (1)
- MTL30 (1)
- MTOR (1)
- MTX (1)
- MU-M (1)
- MUD (1)
- MUST-Score (1)
- MV receptor (1)
- MV transcription (1)
- MVT (1)
- MYB (1)
- MYCNv (1)
- Macaque monkey (1)
- Macrophage Migration Inhibitory Factor (MIF) (1)
- Macrophages (1)
- Mactel 2 (1)
- Maculinea butterfly (1)
- Mad Men (1)
- Madagascar (1)
- Magnesium (1)
- Magnetfeld (1)
- Magnetic resonance imaging(MRI) (1)
- Magnetic-resonance (1)
- Magnetic-resonance microscopy (1)
- Magnetresonanztomografie (1)
- Main-group chemistry (1)
- Maintenance (1)
- Maintenance treatment (1)
- Mais (1)
- Majeed (1)
- Majeed-Syndrome (1)
- Major abdominal surgery (1)
- Major depression (1)
- Major splice donor (1)
- Majorana fermions (1)
- Makrophage (1)
- Malaise trap (1)
- Malaria (1)
- Malaya (1)
- Male (1)
- Male breast cancer (1)
- Male intromittent organ (1)
- Malignancies (1)
- Malignant effusion (1)
- Malignant neoplasms (1)
- Malvaviscus arboreus (1)
- Mamestra brassicae (1)
- MammaJian mutagenicity test (1)
- Mammakarzinom (1)
- Mammalian genomes (1)
- Mammalian target (1)
- Management (1)
- Mandibular condyle (1)
- Mandibular continuity defects (1)
- Manganese (1)
- Manganese Carbonyl ligands (1)
- Mania (1)
- Manifestation (1)
- Mann-Kendall test (1)
- Mansoni infection (1)
- Mantle cell lymphoma (1)
- Marcus inverted region (1)
- Marfan syndrome (1)
- Markarian 501 (1)
- Markov chains (1)
- Marrakech (1)
- Marrow stromal cells (1)
- Martensit (1)
- Mass Spectrum (1)
- Mass critical care (1)
- Mass-spectrometry (1)
- Mast cells (1)
- Masticatory mucosa (1)
- Mastocytosis (1)
- Mastoid process (1)
- Materials chemistry (1)
- Materials science (1)
- Mato Grosso (1)
- Matrix (1)
- Matrix metalloproteinases (1)
- Matter (1)
- Maxwell demon (1)
- Mbt (1)
- McDonald criteria (1)
- McN-A-343 analogs (1)
- Mcl-1 (1)
- MeDALL (1)
- Measurement error correlation (1)
- Measurement invariance (1)
- Measuring masses (1)
- Meat (1)
- Mechanical strain (1)
- Mechanism of action (1)
- Mechanistic model (1)
- Medaka - Genetransfer - Transient expression - DNA fate - Fish developmental biology (1)
- Medaka fish (1)
- Media (1)
- Mediated Inflammatory Hyperalgesia (1)
- Medicago truncatula (1)
- Medical education (1)
- Medical history (1)
- Medical implants (1)
- Medical journals (1)
- Medical overuse (1)
- Medical research (1)
- Medical student (1)
- Medical students (1)
- Medicalization (1)
- Mediterranean environment (1)
- Medulloblastoma (1)
- Medullärer Schilddrüsenkrebs (1)
- Meeresschwämme (1)
- Megalobrama amblycephala (1)
- Megaponera analis (1)
- Mehrskalenmodell (1)
- Meige syndrome (1)
- Meiosis (1)
- Meisenheimer complex (1)
- Mekong-Delta (1)
- Melanocortin 4 receptor (MC4R) (1)
- Melanocyte stimulating hormones MSH (1)
- Melanoma B16 (1)
- Melanoma-cells (1)
- Melatonin (1)
- Meliponini (1)
- Mellitus (1)
- Melophorus-bagoti (1)
- Membranes (1)
- Memory (1)
- Memory B cells (1)
- Memory capacity (1)
- Memory dysfunction (1)
- Men (1)
- Mena/VASP (1)
- Meniere’s disease (1)
- Meningioma (1)
- Meningococcal infection (1)
- Meningococcal polysaccharide caccine (1)
- Meningococcal serogroup C (1)
- Meningococci (1)
- Mental arithmetic (1)
- Mental health therapies (1)
- Merkel cell density (1)
- Merlin (1)
- Merocyanine (1)
- Merogone experiments (1)
- Mesenchymal stem cell (1)
- Mesenchymal transition (1)
- Mesh Augmentation (1)
- Mesoarchaean (1)
- Mesocestoides corti (1)
- Mesoskopisches System (1)
- Messenger RNA (1)
- Messenger Ribonucleoprotein Particles (1)
- Messenger-RNA (1)
- Messenger-RNAs (1)
- Messenger-RNS (1)
- Metaanalysis (1)
- Metabolic profiles (1)
- Metabolism saturation (1)
- Metabolismus (1)
- Metacestode (1)
- Metalloproteinasen (1)
- Metalloradicals (1)
- Metanephrine (1)
- Metapleural gland (1)
- Metarhizium anisopliae (1)
- Metastases (1)
- Metastatic melanoma (1)
- Meta‑analysis (1)
- Methanosarcina mazei (1)
- Methicillin resistant Staphylococcus aureus (1)
- Methicillin-resistant Staphylococcus aureus (1)
- Methicillin-resistant staphylococcus aureus (1)
- Methoctramine (1)
- Methodological quality (1)
- Methylome (1)
- Mexican coffee plantations (1)
- Mexico City (1)
- Mexico [North America] (1)
- Mfn2 KO mice (1)
- MgAl LDH (1)
- MiMIC (1)
- MicroRNAs (1)
- Microarray analysis (1)
- Microarray data (1)
- Microbiology and Infectious Disease (1)
- Microcavity (1)
- Microcavity devices (1)
- Microenvironment (1)
- Microinjection (1)
- Micromonospora (1)
- Micronucleus formation (1)
- Micronucleus test (1)
- Microorganisms (1)
- Mid-infrared photoluminescence (1)
- Middle cerebral-artery (1)
- Midline (1)
- Midollo-Osseo (1)
- Mig1 (1)
- Migration (1)
- Migräne (1)
- Mikroarray (1)
- Mikrobiologie (1)
- Military shooting (1)
- Millisecond-timescale (1)
- Milnesium tardigradum (1)
- Mindfulness (1)
- Mini Unmanned Aerial Vehicle (1)
- Minimal Surface Tension (1)
- Minimal change disease (1)
- Minimal supersymmetric model (1)
- Minimalinvasiv (1)
- Minimalinvasive Leistenhernienversorgung (1)
- Minimally invasive surgery (1)
- Minischwein (1)
- Minor histocompatibility antigen mismatch transplantation (1)
- Minor subunits (1)
- Mip inhibitor (1)
- MircoRNA (1)
- Missense mutation (1)
- Missing Energy (1)
- MitoQ (1)
- Mitochondrial Matrix Protein (1)
- Mitomycin C (1)
- Mitosis (1)
- Mitotane (1)
- MitraClip (1)
- Mitsunobu (1)
- Mitteleuropa (1)
- Miyoshi myopathy (1)
- Mobile Sensor Network (1)
- Mobile application engineering (1)
- Mobile augmented reality (1)
- Mobile augmented reality game (1)
- Mobile genetic element (1)
- Model specification (1)
- Modell (1)
- Modified Nucleotides in tRNAs (1)
- Modifizierte Sugarbaker-Technik (1)
- Molecular Biophysics (1)
- Molecular Channel Transport (1)
- Molecular Imaging (1)
- Molecular beam epitaxy (1)
- Molecular biophysics (1)
- Molecular imaging (1)
- Molecular mechanism (1)
- Molecular pathogenesis (1)
- Molecular systematics (1)
- Molecular-dynamics (1)
- Molecular-genetics (1)
- Molecular-weight heparin (1)
- Molecularly targeted therapy (1)
- Molekulare Infektionsbiologie (1)
- Molekularpathologie (1)
- Molekularpharmakologie (1)
- Molekül (1)
- Molnupiravir (1)
- Molnupiravir-Induced RNA Mutagenesis Mechanism (1)
- Monoamine Oxidase/genetics (1)
- Monoclonal antibody (1)
- Monocytes and macrophages (1)
- Monopolar depression (1)
- Monte Carlo methods (1)
- Monte Carlo simulation (1)
- Monte-Carlo-Simulation (1)
- Mood disorders (1)
- Moose (1)
- Morbidity (1)
- Morbus Fabry (1)
- Morocco (1)
- Motion (1)
- Motion detection (1)
- Motivation (1)
- Motoneuron disease (1)
- Motor behaviour (1)
- Motor cortex (1)
- Motor nerve biopsy (1)
- Motor neuron disease; Ciliary neurotrophic factor; Brain-derived neurotrophic factor; Animal models; Neurotrophic factors (1)
- Motor plasticity (1)
- Mott–Schottky analysis (1)
- Mouse models (1)
- Movement (1)
- Movement behavior (1)
- Mozambique (1)
- Mt. Kinabalu (1)
- Mucin (1)
- Mucopolysaccharidosis IIIa (1)
- Mucor (1)
- Mucorales (1)
- Mud (1)
- Multibranched structures (1)
- Multicenter randomized-trial (1)
- Multidetector computed tomography (1)
- Multimorbidity (1)
- Multiparameter predictor (1)
- Multiple (1)
- Multiple Sklerose (1)
- Multiple Traits (1)
- Multiple drug resistance (1)
- Multiple-Scattering (1)
- Multiple-Sclerosis (1)
- Multiplex PCR (1)
- Multipolar mitosis (1)
- Mund-Kiefer-Gesichts-Chirurgie (1)
- Munigua (1)
- Muon spectrometers (1)
- Mus spretus (1)
- Muscarinic M1 receptors (1)
- Muscarinic M1 receptors; Muscarinic M2 receptors (1)
- Muscarinic M3 receptor subtypes (1)
- Muscarinic M3selective antagonists (1)
- Muscarinic antagonist (1)
- Muscarinic receptor agonists (1)
- Muscarinic receptor antagonists (M 3-selective) (1)
- Muscarinic receptor antagonists (selective) (1)
- Muscarinic receptor subtype (1)
- Muscarinic receptor subtypes; Muscarinic rcceptor agonists (M 1-selective) (1)
- Muscarinie M2 receptors (1)
- Muscidifurax (1)
- Muscle function (1)
- Muscle power (1)
- Musearinic M4 receptors (1)
- Musearlnie M1 (1)
- Musearlnie aeetyleholine receptor agonists (1)
- Musearlnie aeetyleholine receptor antagonists (1)
- Musearlnie receptor subtypes (1)
- Mutagenicity (1)
- Mutagenicity assay (1)
- Mutagens (1)
- Mutant (1)
- Mutation assay (1)
- Mutation screening (1)
- Mwanza (1)
- Myanmar (1)
- Myb-MuvB (1)
- Myc (1)
- Myc Transcription (1)
- Mycobacterium avium (1)
- Mycobacterium caprae (1)
- Mycobacterium marinum (1)
- Mycobacterium tuberculosis complex (1)
- Mycoplasma (1)
- Myelin oligodendrocyte glycoprotein (MOG) antibodies (1)
- Myelitis (1)
- Myeloma cells (1)
- Myelomas (1)
- Myocardial fibrosis (1)
- Myocardial infarction (1)
- Myocardial perfusion (1)
- Myocardial-Infarction (1)
- Myocardial-perfusion SPECT (1)
- Myofibroblast differentiation (1)
- Myokarditis (1)
- Myrmecophytes (1)
- Myrmecophytism ; Malaysia ; trophobionts ; colony foundation ; Cladomyrma (1)
- Myrmica ant non-equilibrium dynamics (1)
- Müller cells (1)
- N-Acetyl-leukotriene E4 (1)
- N-CAM (1)
- N-Heterocyclic Carbene Adducts (1)
- N-Heterocyclic Carbenes (1)
- N-Heterocyclic carbenes (1)
- N-Myc down regulated gene 1 (1)
- N-functionalization (1)
- N-glycans (1)
- N-heterocyclic olefins (1)
- N-methyl-N-nitrosourea (1)
- N-methylpyridinium pyrene (1)
- N-oleoyl serinol (1)
- N-terminal domain (1)
- N100 (1)
- N1E 115 cells (1)
- N400 (1)
- NA (1)
- NA+/I-symporter (1)
- NA/I symporter (1)
- NAD (1)
- NAD(P)H-dehydrogenase (1)
- NAD(P)H-plastoquinone-oxidoreductase (1)
- NADH-dehydrogenase (1)
- NADPH (1)
- NADPH oxidase (1)
- NADPH oxidase 2 (NOX2) (1)
- NADPH oxidase inhibitors (1)
- NADPH oxidases (NOX) (1)
- NAKO (1)
- NAP-2 (1)
- NAS (1)
- NBAS (1)
- NCAM1 (1)
- NCH93 (1)
- NCI-60 (1)
- NCI-H295R (1)
- ND10 complex (1)
- NDH-H (1)
- NDH-I (1)
- NDH-J (1)
- NDH-K (1)
- NDI-H (1)
- NDVI thresholds (1)
- NEAT1 (1)
- NEC (1)
- NEIL2 (1)
- NETs (1)
- NEXAFS spectroscopy (1)
- NF-\(\kappa\)B (1)
- NF-\(\kappa\)B pathway (1)
- NF-κB/NFAT reporter cells (1)
- NF2-related schwannomatosis (NF2) (1)
- NFE2L2 (1)
- NFKB (1)
- NFkB-relatedgenes (1)
- NFkappaB (1)
- NFκB-activation (1)
- NHC Complexes (1)
- NHCs (1)
- NHLRC2 (1)
- NHX1 (1)
- NH\(_{3}\) (1)
- NI(111) (1)
- NIHSS (1)
- NIPAL4 (1)
- NIR OLED (1)
- NIRS (1)
- NK cell (1)
- NK cell deficiency (1)
- NK-cells (1)
- NKG2D (1)
- NKG2D ligands (1)
- NLO QCD (1)
- NLPHL (1)
- NMD (1)
- NMDA receptor subunits NR2A and NR2B (1)
- NMDA-Antagonist (1)
- NMDA-Rezeptor (1)
- NMJ–neuromuscular junction (1)
- NMO-IGG (1)
- NMO-IgG (1)
- NMR fingerprint (1)
- NMR relaxation (1)
- NMR-Tomographie (1)
- NMR-spectroscopy (1)
- NNLO (1)
- NO (1)
- NOP10 (1)
- NP-hard (1)
- NP-hardness (1)
- NPC1 gene (1)
- NPC2 gene (1)
- NPSI (1)
- NPSR1 (1)
- NPU (1)
- NPWT (1)
- NR3C1 (1)
- NRAS mutation (1)
- NRG1 (1)
- NS1608 (1)
- NSAIDs (1)
- NSG animals (1)
- NSG mice (1)
- NSG-SGM3 (1)
- NSG-UC (1)
- NT-proBNP (1)
- NTCDA (1)
- NTP-binding-properties (1)
- NT‐proBNP (1)
- NVP-BGT226 (1)
- NaCl transport (1)
- NaV1.8 (1)
- NaV1.9 (1)
- Na\(_V\)1.8 (1)
- Nail unit (1)
- Naive T cells (1)
- Namibia (1)
- Nampt (1)
- Nanda-Hamner (1)
- NanoFEEP (1)
- Nanog protein (1)
- Nanos (1)
- Naphthylisoindolinone alkaloids (1)
- Nasal Carriage (1)
- Nash bargaining problem (1)
- Nash equilibria (1)
- Nash equilibrium (1)
- Nasonia (1)
- Nasonia courtship (1)
- Natalizumab (1)
- National Science Foundation (1)
- Natural product hybrids (1)
- Natural-history data (1)
- Ndrg1 (1)
- Neanderthal (1)
- Necrosis (1)
- Necrosis-factor-Alpha (1)
- Necrotizing enterocolitis (1)
- Nectin‐2 (1)
- Negative geotaxis (1)
- Neisseria (1)
- Nekrose (1)
- Nematode Caenorhabditis-elegans (1)
- Neoblast (1)
- Neolithic (1)
- Neolithic agriculture (1)
- Neolithic period (1)
- Neomycin Resistance (1)
- Neostriatum (1)
- Nephroblastoma (1)
- Neprilysin inhibition (1)
- Nerve fibers (1)
- Nerve growth factor (1)
- Nerve growth-factorcopy (1)
- Nervous system (1)
- Nesplora Aquarium (1)
- Nestin (1)
- Nesting resources (1)
- Netarsudil (1)
- Netherlands (1)
- Netrin (1)
- Network (1)
- Neugeborenes (1)
- Neural Differentiation (1)
- Neural basis (1)
- Neural crest cells (1)
- Neural precursor cells (1)
- Neuralgie (1)
- Neuritis (1)
- Neuro-blastoma (1)
- Neuroblastoma (1)
- Neuroendocrine (1)
- Neuroendocrine Tumor (1)
- Neurofilament (1)
- Neurogenic inflammation (1)
- Neurogenie inflammation (1)
- Neuroinfectiology (1)
- Neuroinflammation (1)
- Neuromuscular junctions (1)
- Neuromyelitis optica (NMO) (1)
- Neuromyelitis optica antibodies (NMO-IgG) (1)
- Neuronal plasticity (1)
- Neuronal survival (1)
- Neuronales Netz (1)
- Neurone number (1)
- Neuropeptide (1)
- Neuropeptides (1)
- Neuroscience (1)
- Neurosciences (1)
- Neurotropathic Factor (1)
- Neurotrophin (1)
- Neutrino (1)
- Neutrino Detectors and Telescopes (experiments) (1)
- Neutrino Mass (1)
- Neutrino data (1)
- Neutrino detectors (1)
- Neutrino emission (1)
- Neutrino mass mixing (1)
- Neutrino telescope (1)
- Neutrophil (1)
- Neutrophils (1)
- New Species (1)
- New mexico (1)
- Newton methods (1)
- NfL (1)
- Nicandra (1)
- Nicardipine (1)
- Nickel ComplexCyclic (1)
- Nickel Complexes (1)
- Niedere Wirbeltiere (1)
- Niemann–Pick disease type C (1)
- Niere (1)
- Nierenfunktionsstörung (1)
- Niger <Ost> (1)
- Nile Delta (1)
- Nile Delta (Egypt) (1)
- Nile delta (1)
- Nile flow (1)
- Nissl stain (1)
- Nitric oxide (NO) (1)
- Nitric-oxide (1)
- Nitrogen metabolism (1)
- Nitrosation (1)
- Nitrosierung (1)
- Nivolumab (1)
- Njassasee (1)
- Nodo-parandopathy (1)
- Nodule (1)
- Nogo-A (1)
- Noise stimulation (1)
- Non-penetrating glaucoma surgery (1)
- Non-phototrophic bacteria (1)
- Non-reactive Measurement (1)
- Non-rigid image registration (1)
- Non-simultaneous bilateral distal biceps tendon rupture (1)
- Non-steroidal anti-inflammatory drug (1)
- Nonlinear Dynamics (1)
- Nonpathogenic Escherichia-coli (1)
- Nonverbal communications (1)
- Non‐ischaemic cardiogenic shock (1)
- Norbert Groeben (1)
- Normal Distribution (1)
- Normal breast (1)
- Normal tissue tolerance (1)
- Normetanephrine (1)
- North American (1)
- Northeastern Costa Rica (1)
- Northern Bald Ibis (1)
- Northern Xinjiang (1)
- Notch1 (1)
- Nothotaxa (1)
- Novel PI3K (1)
- Novobiocin (1)
- Npy (1)
- Npyr1 (1)
- Npyr2 (1)
- NuMA (1)
- Nuclear (1)
- Nuclear RDNA (1)
- Nuclear envelope (1)
- Nuclear expression (1)
- Nuclear pore complex (1)
- Nuclear pores (1)
- Nucleic Acids (1)
- Nucleobase Analogue (1)
- Nucleocytoplasmic exchange (1)
- Nucleocytoplasmic transport (1)
- Nucleolus-DNA (1)
- Nucleus (1)
- Nucleus accumbens (1)
- Nurses (1)
- Nursing homes (1)
- N‐Heterocyclic Carbenes (1)
- O6-alkylguanine-DNA alkyltransferase (1)
- OAT1 (1)
- OAT3 (1)
- OBF-1 OCA-B (1)
- OCB (1)
- OCSVM (1)
- OCT angiography (1)
- OCT-1-deficient mice (1)
- ODE (1)
- OECD guideline (1)
- OEG chains (1)
- OGG1 (1)
- OHIP-49 (1)
- OHIP-G14 (1)
- OHRQoL (1)
- OK cells (1)
- OLED (1)
- OLEDs (1)
- OLFM4 (1)
- ONJ (1)
- OPS201 (1)
- OPT (1)
- OPUS (1)
- OSC (1)
- OSCC (1)
- OSI (1)
- OSM (1)
- OXPHOS (1)
- OXTR (1)
- Obesity history (1)
- Object recognition (1)
- Observational study (1)
- Obturator bypass (1)
- Ockham (1)
- Oct4 (1)
- Octavalen (1)
- Oculomotor Muscles/physiology (1)
- Oesling (1)
- Ofatumumab (1)
- Oil (1)
- Oilseed rape (1)
- Oldenburg burnout inventory (1)
- Olefin Complexes (1)
- Olfr1393 (1)
- Olig2 (1)
- Oligoclonal bands (1)
- Oligofructoside (1)
- Omp85 (1)
- Oncogene (1)
- Oncolysis (1)
- Oncolytic action (1)
- Oncolytic vaccinia virus (1)
- Oncolytic virotherapy (1)
- Oncostatin-M-Receptor (1)
- OncotypeDX\(^{®}\) (1)
- One Health (1)
- One-loop Effective Potential (1)
- One-photon (1)
- Onset hypertrophic cardiomyopathy (1)
- Ontogeny (1)
- Oogenesis (1)
- Open source reconstructed epidermis (1)
- Open-source tool (1)
- Openfield test (1)
- Opioid receptor (1)
- OprO (1)
- OprP (1)
- OpsA (1)
- Opsins (1)
- Optical Activity (1)
- Optical Flow (1)
- Optical Music Recognition (1)
- Optical Spectroscopy (1)
- Optical coherence tomography (1)
- Optical control (1)
- Optical properties (1)
- Optogenetics (1)
- Orai2 (1)
- Oral anticoagulation (1)
- Oral antidiabetic drugs (1)
- Oral squamous cell carcinoma (1)
- Oralchirurgie (1)
- Oralsekret (1)
- Ordination methods (1)
- Organ motion (1)
- Organelles (1)
- Organoazides (1)
- Organoids (1)
- Orobanche crenata (1)
- Orthogonal field attenuation gel electrophoresis (1)
- Orthopädische Chirurgie (1)
- Oryza sativa (1)
- Oscillation (1)
- Oshana (1)
- Osmia (1)
- Osmia bicornis (1)
- Osmoregulation (1)
- Osmunda regalis (1)
- Osseointegration (1)
- Ostasien (1)
- Osteoarthrosis (1)
- Osteogeneration (1)
- Osteogenic precursor cells (1)
- Osteology (1)
- Osteomyelitis of the humerus (1)
- Osteopontin (1)
- Osteoporosis (1)
- Otolaryngolgy (1)
- Outcome (1)
- Outcomes (1)
- Outer membrane proteins (1)
- Outlier detection (1)
- Ovarian (1)
- Overdiagnosis (1)
- Overeating (1)
- Own-name (1)
- Oxford knee score (1)
- Oxide synthase gene (1)
- OxyR (1)
- Oxygen radical (1)
- Oxygen uptake (1)
- Oxyphencyclimine (1)
- O–I 1 fluorescence rise (1)
- P(P) over-bar collisions (1)
- P(P)over-bar collicions (1)
- P-cresyl sulfate (1)
- P-fimbriae (1)
- P-glycoprotein expression (1)
- P-gp (1)
- P-gp inhibitors (1)
- P. aeruginosa (1)
- P. falciparum (1)
- P100 (1)
- P14ARF (1)
- P15(INK4B) (1)
- P21 (1)
- P300 speller (1)
- P300 topography (1)
- P300-Speller (1)
- P515 (1)
- P67(PHOX) (1)
- P75 Neurotrophin receptor (1)
- P97 (1)
- PA-flexed view (1)
- PABC1 (1)
- PABP (1)
- PABPs (1)
- PAF-acether (1)
- PAG (1)
- PAH formation (1)
- PAI-1 (1)
- PAK4 (1)
- PALS (1)
- PAM2 (1)
- PAM2w (1)
- PAPA syndrome (1)
- PAR (1)
- PAR-CLIP (1)
- PARM (1)
- PARROT (1)
- PB-PB Collisions (1)
- PBEF (1)
- PBI cyclophane (1)
- PBM (1)
- PBPK/PBTK model (1)
- PC-1 blockade (1)
- PCDHGC3 (1)
- PCI (1)
- PCI-32765 (1)
- PCL retention (1)
- PCLS (1)
- PCR analysis (1)
- PCR diagnostics (1)
- PCa (1)
- PDE2 (1)
- PDE4-I (1)
- PDE4-inhibitor roflumilast (1)
- PDE4d (1)
- PDF set (1)
- PDGF (1)
- PDH (1)
- PD‐L1 (1)
- PEComa (1)
- PEGylation (1)
- PER-TIM complex (1)
- PEST (1)
- PET imaging (1)
- PET-1 (1)
- PET/MR systems (1)
- PETRI-seq (1)
- PF-05231023 (1)
- PF4 (1)
- PFA in ethanol (1)
- PFS25 (1)
- PGAS (1)
- PHQ-9 (1)
- PI stacking (1)
- PI-3-kinase (1)
- PI3K isoforms (1)
- PI3K/Akt/mTOR (1)
- PIA/ica (1)
- PICD (1)
- PIK3CA mutations (1)
- PIK3R1 (1)
- PKA (1)
- PKB/Akt phosphorylation (1)
- PKCζ, (1)
- PKM2 (1)
- PKS I (1)
- PKS II (1)
- PLAG1 rearrangement (1)
- PLEKHG5 (1)
- PML nuclear-bodies (1)
- PMMA bone cement (1)
- PMNs (1)
- PMR (1)
- PNA (peptide nucleic acid) (1)
- PO (1)
- POEM (1)
- POLO-chart (1)
- POLSCORE (1)
- POTRA domain (1)
- POU6F2-AS2 (1)
- POZ domain (1)
- PP Collicions (1)
- PP collisions (1)
- PP2A (1)
- PPAR-gamme (1)
- PPGPP (1)
- PPIase (1)
- PRAME (1)
- PRO (1)
- PROM’s (1)
- PRPF31 (1)
- PSA response (1)
- PSI-blast (1)
- PSMA PET/CT (1)
- PSMA-617 (1)
- PSMA-PET (1)
- PSMA-TV (1)
- PSMA‐617 (1)
- PSMC2 (1)
- PSP (1)
- PTA (1)
- PTCDA (1)
- PU.1 (1)
- PUFA (1)
- PUMP (1)
- PWV (1)
- PYY3-36 (1)
- Pacific Ocean (1)
- Paenibacillus (1)
- Paenibacterin (1)
- Paeonia (1)
- Pain questionnaire (1)
- Pain threshold ; Smoking ; Nicotine ; Acute tolerance ; Deprivation ; Psychophysiologicat measures (1)
- Pain-related evoked potentials (1)
- Pair Prodution (1)
- Pair-Production (1)
- Paleopedology (1)
- Palladium-catalyzed silaboration (1)
- Palliativmedizin (1)
- Palmoplantar keratoderma (1)
- Pamir (1)
- Pan1 (1)
- Pancreatic islet (1)
- Panic Disorder/genetics (1)
- Panic Disorder/therapy (1)
- Paprosky (1)
- Paradoxical heat sensation (1)
- Paraganglioma (1)
- Parallel fiber synapses (1)
- Parametric down-conversion (1)
- Parasite (1)
- Parasite development (1)
- Parastomale Hernie (1)
- Parataxonomy (1)
- Parent Piano-Stool Complex (1)
- Parent-of-origin (1)
- Parent–Child Interaction Therapy (PCIT) (1)
- Parietal cortex (1)
- Parkinsons diesease (1)
- Parkinsons-disease (1)
- Parkionson's disease (1)
- Partially parallel acquisitions (1)
- Particle accelerators (1)
- Particle dark matter (1)
- Particle physics (1)
- Particle production (1)
- Particle properties (1)
- Particle tracking detectors (Gaseous detectors) (1)
- Particle-acceleration (1)
- Particles (1)
- Partnership (1)
- Parton Ditributions (1)
- Parvovirus (1)
- Path-integraton (1)
- Pathogenesis (1)
- Pathogenicity (1)
- Pathologic neovascularization (1)
- Pathology (1)
- Patient Blood Management (PBM) (1)
- Patient Controlled Analgesia (1)
- Patient Satisfaction (1)
- Patient education (1)
- Patient-centered care (1)
- Patient-centered registry (1)
- Patient’s needs (1)
- Pattern classification (1)
- Pauli procedure (1)
- Pauli-Verfahren (1)
- Pavlovian-to-instrumental transfer (1)
- Pearson correlation coefficient (1)
- Pediatric (1)
- Pediatric malignancy (1)
- Pedicled perforator flap (1)
- Pelvic tumors (1)
- Pelvisio® (1)
- Pentastomiasis (1)
- Pentixafor (1)
- Peptidase inhibitor 16 (PI16) (1)
- Peptide receptor radionuclide therapy (1)
- Peptide-leukotrienes (1)
- Peptidoglycan recognition (1)
- Perception (1)
- Performance (1)
- Perfusion (1)
- Perinatal Asphyxia (1)
- Period (1)
- Peripheral Inflammation (1)
- Peripheral blood lymphocytes (1)
- Peripheral nervous system (1)
- Perovskite (1)
- Personality (1)
- Personalized medicine (1)
- Perturbative QCD (1)
- Perugia-Kärpfling (1)
- Peter Singer (1)
- Petropedetidae (1)
- Peyer's patches (1)
- PfAMA1 (1)
- PfCCp protein (1)
- Pfam domain (1)
- Pflanzen (1)
- Pflanzeninhaltsstoff (1)
- Pfs230 (1)
- Phacocanaloplasty (1)
- Phacotrabeculectomy (1)
- Phaeophyceae (1)
- Pharmacokinetics (1)
- Pharmacological management (1)
- Phase II trial (1)
- Phase II trials (1)
- Phase- (1)
- Phasenumwandlung (1)
- Phedimus middendorffianus, var. diffusus (1)
- Phedimus spurius subsp. oppositifolius (1)
- PhenoCam (1)
- Phenolic acids (1)
- Phenols (1)
- Pheromone (1)
- Phoenix dactylifera (1)
- Phonological awareness (1)
- Phosphatidylinositol metabolism (1)
- Phosphodiesterase (1)
- Photic (1)
- Photoactivated localization microscopy (1)
- Photoaffinity labelling (1)
- Photocatalysis (1)
- Photoelektron (1)
- Photoelektronenspektroskopie (1)
- Photon detectors for UV, visible and IR photons (vacuum) (1)
- Photon migration (1)
- Photons (1)
- Photosystem I (1)
- Phrynobatrachus amphibia (1)
- Phylogenetics (1)
- Phylogenie (1)
- Physalis (1)
- Physical Activity (1)
- Physical Sciences (1)
- Physical fitness (1)
- Physical impairment (1)
- Physical sciences (1)
- Physics and instrumentation (1)
- Physiological functions (1)
- Physiologically based kinetic models (1)
- Picea mariana (1)
- Pigmentarchitectonics (1)
- Pilot studies (1)
- Pilus (1)
- Pilzbefall (1)
- Pinus sylvestris L. (1)
- Pirenzepine (1)
- Pitfall (1)
- Pithed rat (1)
- Pitrakinra (1)
- Pityriasis lichenoides (1)
- PknB (1)
- Placebo-controlled trial (1)
- Planetary Health (1)
- Planetary Health Education (1)
- Plant growth promotion (1)
- Plant root endophyte (1)
- Plant signalling (1)
- Plant utricularia-gibba (1)
- Plant-herbivore interactions (1)
- Plant-insect interactions (1)
- Plantation forests (1)
- Plasma (1)
- Plasma extravasation (1)
- Plasmid (1)
- Plastid DNA (1)
- Plataspidae (1)
- Platelet-derived growthfactor (1)
- Platform economy (1)
- Pleckstrin homology containing family member 5 (Plekhg5) (1)
- Pleistocene (1)
- Pleistozän (1)
- Plumbylenes (1)
- Pluripotency (1)
- Plus (1)
- Plus Plus (1)
- Pneumococcal vaccination (1)
- Pneumococci (1)
- Pneumocystis-carinii-pneumonia (1)
- Pnictogen reduction (1)
- Po (1)
- Podocarpus National Park (1)
- Poecilia (Teleostei: Poeciliidae) (1)
- Poecilia reticulata (1)
- Poeciliid fish (1)
- Pointing error (1)
- Pointmutation (1)
- Poisson algebras (1)
- Poisson surface reconstruction (1)
- Pol II (1)
- Polanyi (1)
- Polarimetric Synthetic Aperture Radar (PolSAR) (1)
- Polarity index (1)
- Polistine wasps (1)
- Politik (1)
- Pollination (1)
- Pollinators (1)
- Poly(A) binding protein (1)
- Polyadenylation (1)
- Polyadenylierung (1)
- Polycistronic mRNA (1)
- Polygonum cuspidatum (1)
- Polylactide-co-glycolide (1)
- Polymer-drug interaction (1)
- Polymerase chain raction (1)
- Polymers (1)
- Polymorphisms (1)
- Polyoma-Virus (1)
- Polyphasic fluorescence rise (1)
- Polyphenols (1)
- Polyspermy (1)
- Pompe disease (1)
- Pom‐PAD‐Dara (1)
- Pontryagin maximum principle (1)
- Poor-prognosis (1)
- Poplars (1)
- PorB (1)
- Porcine eye (1)
- Porifera (1)
- Porphyrin arrays (1)
- Port (1)
- Portland cement (1)
- Positioning (1)
- Positive-Pressure Respiration (1)
- Positron Emission Tomography (1)
- Positron annihilation spectroscopy (1)
- Positron-Emission Tomography (1)
- Positron-emission-tomography (1)
- Positronenemissionstomografie (1)
- Post-traumatic stress disorder (1)
- Posteriore Komponentenseparation (1)
- Postmarketing Experience (1)
- Postoperative complications (1)
- Potential-energy curves (1)
- Potentials (1)
- Pou2af1 (1)
- Practice (1)
- Practitioner's guide (1)
- Precipitation gradient (1)
- Preclinical evaluation (1)
- Predict fluid responsiveness (1)
- Prediction (1)
- Predictions (1)
- Predictive toxicology (1)
- Predictive value of tests (1)
- Predictors (1)
- Prednisolon (1)
- Predominant polarity (1)
- Pregnancy (1)
- Premna (1)
- Preserved Ejection Fraction (1)
- Preterm birth (1)
- Pre‐Ligand Assembly Domain (PLAD) (1)
- Prfa-mediated virulence (1)
- Primary care (1)
- Primary cell lines (1)
- Primary endosymbiont (1)
- Primary hyperparathyroidism (pHPT) (1)
- Primitive neuroectodermal (1)
- ProQ (1)
- Probabilities (1)
- Probenecid (1)
- Problem size (1)
- Process Model Comprehension (1)
- Prodigy (1)
- Production Cross-Section (1)
- Production cross-section (1)
- Proenzyme (1)
- Professionalism (1)
- Profile distances (1)
- Profilierung (1)
- Profiling (1)
- Progenitor cells (1)
- Prognosis (1)
- Prognostic impact (1)
- Prognostic markers (1)
- Prognostic scoring system (1)
- Programm (1)
- Programmed Cell Death 1 Receptor (1)
- Programmed cell-death (1)
- Programmierbare logische Anordnung (1)
- Progression (1)
- Progressive motor neuronopathy (1)
- Progressive multifocal leukoencephalopathy (1)
- Progressive supranuclear palsy (1)
- Prolactin (1)
- Promoter prediction (1)
- Promotor (1)
- Propagation (1)
- Propeller flap (1)
- Property rights approach (1)
- Proprioception (1)
- Prosaccade (1)
- Prostaglandins (1)
- Prostata (1)
- Prostatakrebs (1)
- Prostate carcinoma (1)
- Prostate-cancer (1)
- Protease inhibition (1)
- Proteasen (1)
- Protection (1)
- Protein binding (1)
- Protein coding (1)
- Protein folding (1)
- Protein function prediction (1)
- Protein kinase B (1)
- Protein kinase D3 (PKD3) (1)
- Protein transduction (1)
- Proteine (1)
- Proteins (1)
- Proteogenomics (1)
- Proteomanalyse (1)
- Proteus vulgaris (1)
- Proton-Proton- Collisions (1)
- Protons (1)
- Protoonkogen (1)
- Protopterus annectens (1)
- Protoscolex (1)
- Prototype (1)
- Pruno-Rubion sprengelii (1)
- Prunus-africana (1)
- Präferenz (1)
- Pseudo-allergy (1)
- Pseudomonas (1)
- Pseudomonas-aeruginosa (1)
- Pseudorapidity (1)
- Pseudotsuga menziesii (1)
- Psychisch Kranker (1)
- Psychological distress (1)
- Psychology (1)
- Psychometrics (1)
- Psychomotor Performance/physiology (1)
- Psychopathology (1)
- Psychopharmakologie (1)
- Psychotherapie (1)
- Pt (1)
- Pteromalidae (1)
- Pulmonary Embolism (1)
- Pulmonary function (1)
- Pulmonary function tests (1)
- Pulmonary hypertension (1)
- Puls-pressure variation (1)
- Pulse shaping (1)
- Purification (1)
- Purpureocillium (1)
- Pycnogenol (1)
- Pyrrinol (1)
- Pädagogische Psychologie (1)
- Q. brantii (1)
- QCD Corrections (1)
- QCD background (1)
- QCM (1)
- QGP-1 (1)
- QIVIVE (1)
- QKD (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (1325)
- Physikalisches Institut (357)
- Institut für Psychologie (351)
- Neurologische Klinik und Poliklinik (340)
- Medizinische Klinik und Poliklinik II (332)
- Medizinische Klinik und Poliklinik I (329)
- Institut für Molekulare Infektionsbiologie (293)
- Institut für Anorganische Chemie (252)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (242)
- Institut für Organische Chemie (231)
Sonstige beteiligte Institutionen
- Johns Hopkins School of Medicine (11)
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (7)
- Clinical Trial Center (CTC) / Zentrale für Klinische Studien Würzburg (ZKSW) (5)
- Wilhelm-Conrad-Röntgen-Forschungszentrum für komplexe Materialsysteme (5)
- Bernhard-Heine-Centrum für Bewegungsforschung (4)
- Johns Hopkins University School of Medicine (4)
- Zentraleinheit Klinische Massenspektrometrie (4)
- Center for Interdisciplinary Clinical Research, Würzburg University, Würzburg, Germany (2)
- Interdisciplinary Center for Clinical Research (2)
- Interdisziplinäres Zentrum für Klinische Forschung (IZKF) (2)
ResearcherID
- D-1221-2009 (1)
EU-Project number / Contract (GA) number
- 602805 (25)
- 701983 (24)
- 669054 (16)
- 682586 (15)
- 728018 (15)
- 787937 (12)
- 224631 (10)
- 288566 (10)
- 602133 (10)
- 646737 (9)
- 244090 (7)
- 309962 (7)
- 259867 (6)
- 643051 (6)
- 823881 (6)
- 101007642 (5)
- 241778 (5)
- 336012 (5)
- 223153 (4)
- 223175 (4)
- 226852 (4)
- 250194 (4)
- 311781 (4)
- 311932 (4)
- 336305 (4)
- 607051 (4)
- 617989 (4)
- 677819 (4)
- 766118 (4)
- 813871 (4)
- 825575 (4)
- 848261 (4)
- 01EW1902 (3)
- 223138 (3)
- 247919 (3)
- 261357 (3)
- 287320 (3)
- 289706 (3)
- 339306 (3)
- 602300 (3)
- 614623 (3)
- 633983 (3)
- 667302 (3)
- 669830 (3)
- 678119 (3)
- 686070 (3)
- 733297 (3)
- 759139 (3)
- 824128 (3)
- 018741 (2)
- 201099 (2)
- 227632 (2)
- 245009 (2)
- 250320 (2)
- 262055 (2)
- 265432 (2)
- 268985 (2)
- 277775 (2)
- 281338 (2)
- 304617 (2)
- 305312 (2)
- 308377 (2)
- 312325 (2)
- 315877 (2)
- 316704 (2)
- 318798 (2)
- 327199 (2)
- 335568 (2)
- 340983 (2)
- 503474 (2)
- 618045 (2)
- 636930 (2)
- 654148 (2)
- 680966 (2)
- 693023 (2)
- 721016 (2)
- 721394 (2)
- 722046 (2)
- 754658 (2)
- 758985 (2)
- 761307 (2)
- 764860 (2)
- 765937 (2)
- 847507 (2)
- 897276 (2)
- 946184 (2)
- 953327 (2)
- 956414 (2)
- 011937 (1)
- 018696 (1)
- 026155 (1)
- 031A408B (1)
- 031A409B (1)
- 037220 (1)
- 037602 (1)
- 0800978 (1)
- 101003595 (1)
- 10100764 (1)
- 101015930 (1)
- 101016923 (1)
- 101034412 (1)
- 101041177 (1)
- 101042738 (1)
- 101045956 (1)
- 101052587 (1)
- 101065772 (1)
- 101076402 (1)
- 101079460 (1)
- 115300 (1)
- 115525 (1)
- 18741 (1)
- 19-COP-0031 (1)
- 20-3044-2-11 (1)
- 20100317 (1)
- 20100407 (1)
- 201024 (1)
- 201052 (1)
- 2016 FGR 0053 (1)
- 201962 (1)
- 2020010013 (1)
- 202088 (1)
- 202213 (1)
- 203291 (1)
- 211078 (1)
- 212372 (1)
- 212525 (1)
- 214469 (1)
- 216027 (1)
- 216886 (1)
- 222719 (1)
- 222943 (1)
- 223044 (1)
- 224635 (1)
- 227159 (1)
- 229289 (1)
- 229294 (1)
- 229571 (1)
- 230331-PROPEREMO (1)
- 232944 (1)
- 241447 (1)
- 241592 (1)
- 241719 (1)
- 241909 (1)
- 242175 (1)
- 242175-VascuBone (1)
- 242175‐VascuBone (1)
- 242257 (1)
- 243964 (1)
- 247447 (1)
- 249177 (1)
- 249929 (1)
- 250194-Carnivorom (1)
- 253511 (1)
- 257531 (1)
- 259735 (1)
- 259753 (1)
- 260338 (1)
- 260986 (1)
- 261474 (1)
- 261492 (1)
- 26230120009 (1)
- 262773 (1)
- 266777 (1)
- 267436 (1)
- 268962 (1)
- 270089 (1)
- 270212 (1)
- 274769 (1)
- 27731 (1)
- 278864 (1)
- 278864-2 (1)
- 279062 (1)
- 286213 (1)
- 289442 (1)
- 289600 (1)
- 290605 (1)
- 291377 (1)
- 291840 (1)
- 294683 (1)
- 294823 (1)
- 296679 (1)
- 297557 (1)
- 303674 (1)
- 304961 (1)
- 305653 (1)
- 306387 (1)
- 306447 (1)
- 307701 (1)
- 307955 (1)
- 311575 (1)
- 312147 (1)
- 314911 (1)
- 316633 (1)
- 316790 (1)
- 318987 (1)
- 320377 (1)
- 320570 (1)
- 322865 (1)
- 324612 (1)
- 339728 (1)
- 340602 (1)
- 506675 (1)
- 517836 (1)
- 602102 (1)
- 602531 (1)
- 602812 (1)
- 604391 (1)
- 606950 (1)
- 609,020 (1)
- 610307 (1)
- 613931 (1)
- 615613 (1)
- 616346 (1)
- 617198 (1)
- 617891 (1)
- 633784 (1)
- 634361 (1)
- 634935 (1)
- 638536 (1)
- 638988 (1)
- 639445 (1)
- 640012 (1)
- 641458 (1)
- 641833 (1)
- 643238 (1)
- 644076 (1)
- 645993 (1)
- 647281 (1)
- 647426 (1)
- 649124 (1)
- 654000 (1)
- 658195 (1)
- 660375 (1)
- 667421 (1)
- 667787 (1)
- 668036 (1)
- 668353 (1)
- 668679 (1)
- 677302 (1)
- 679288 (1)
- 681103 (1)
- 686271 (1)
- 692185 (1)
- 694913 (1)
- 695376 (1)
- 696802 (1)
- 716344 (1)
- 720270 (1)
- 722064 (1)
- 723770 (1)
- 725832 (1)
- 739593 (1)
- 741491 (1)
- 755523 (1)
- 759206 (1)
- 772376 (1)
- 776019 (1)
- 777215 (1)
- 810850 (1)
- 818182 (1)
- 818846 (1)
- 819800 (1)
- 834709 (1)
- 835102) (1)
- 836421 (1)
- 840741 (1)
- 848002 (1)
- 853546 (1)
- 853988 (1)
- 862665 (1)
- 871158 (1)
- 874758 (1)
- 874827 (1)
- 955910 (1)
- 955974 (1)
- 956548 (1)
- 965286 (1)
- BWF/H/52228/2012/13.10.10-1/3.4,6 (1)
- CP22/00082 (1)
- CoG 721016–HERPES (1)
- ERC-2013-StG-336305 (1)
- ERC-2016-CoG 721016-HERPES (1)
- ERC-2018-ADG/NCI-CAD (1)
- ERC335568 (1)
- ESF-ZDEX 4.0 (1)
- ESF_14-BM-A55-0005_16 (1)
- EU-1650-0006 (1)
- EU250194 (1)
- FKZ01EW1902 (1)
- FOOD‑CT‑2004‑506378 (1)
- FP7-ICT MINIMAL (1)
- FP7/2007-2013 (1)
- HEALTH-F2-2009-241778 (1)
- HEALTHF2- 2008-201099 (1)
- LIFE12 BIO/AT/000143 (1)
- LIFE20 NAT/AT/000049 (1)
- LaserLab Europe (LLC001917) (1)
- PI21/00314 (1)
- PIEF-GA-2013-623006 (1)
- PITN-GA-2012-316704 (1)
- PTQ2020-011372 (1)
- QLK1-2001-01614 (1)
- RTI2018-093747-B-10 (1)
- ZAM 5-85018031 (1)
Context
Habitat loss and degradation impose serious threats on biodiversity. However, not all habitats receive the attention commensurate with their ecological importance. Shrub ecotones (successional stages between grasslands and forests) can be highly species-diverse but are often restricted to small areas as prevalent management practices either promote open grassland or forest habitats, threatening the effective conservation of ecotone species.
Objectives
In this study, we assessed the importance of habitat and landscape features of shrub ecotones for the rarely studied true bugs (Heteroptera), a functionally diverse taxon that comprises highly specialized species and broad generalists.
Methods
True bugs were sampled with a beating tray in 118 spatially independent shrub ecotones in a region of 45,000 square kilometers in Germany. In addition to habitat area and landscape context, we used a hedge index to evaluate habitat quality.
Results
Shrub ecotones in open habitats harbored a greater species richness and abundance compared to shaded ones in later seral stages, and species composition differed. Richness and abundance were positively affected by increasing habitat area and quality, whereas an increase in the proportion of semi-natural habitats within 1 km only enhanced richness. While feeding and habitat specialists were more sensitive to habitat area reduction than generalists, this was not the case for weak dispersers and carnivores.
Conclusions
Our findings emphasize the importance of large and high-quality ecotones that form a patchy mosaic of shrubs and herbaceous plants. Such ecotones can benefit both grassland species and species depending on woody plants. Conservation authorities should balance between promoting shrubs and keeping such habitats open to maximize species diversity.
RNA-binding proteins emerge as effectors of the DNA damage response (DDR). The multifunctional non-POU domain-containing octamer-binding protein NONO/p54\(^{nrb}\) marks nuclear paraspeckles in unperturbed cells, but also undergoes re-localization to the nucleolus upon induction of DNA double-strand breaks (DSBs). However, NONO nucleolar re-localization is poorly understood. Here we show that the topoisomerase II inhibitor etoposide stimulates the production of RNA polymerase II-dependent, DNA damage-inducible antisense intergenic non-coding RNA (asincRNA) in human cancer cells. Such transcripts originate from distinct nucleolar intergenic spacer regions and form DNA–RNA hybrids to tether NONO to the nucleolus in an RNA recognition motif 1 domain-dependent manner. NONO occupancy at protein-coding gene promoters is reduced by etoposide, which attenuates pre-mRNA synthesis, enhances NONO binding to pre-mRNA transcripts and is accompanied by nucleolar detention of a subset of such transcripts. The depletion or mutation of NONO interferes with detention and prolongs DSB signalling. Together, we describe a nucleolar DDR pathway that shields NONO and aberrant transcripts from DSBs to promote DNA repair.
The transcription factor SPT5 physically interacts with MYC oncoproteins and is essential for efficient transcriptional activation of MYC targets in cultured cells. Here, we use Drosophila to address the relevance of this interaction in a living organism. Spt5 displays moderate synergy with Myc in fast proliferating young imaginal disc cells. During later development, Spt5-knockdown has no detectable consequences on its own, but strongly enhances eye defects caused by Myc overexpression. Similarly, Spt5-knockdown in larval type 2 neuroblasts has only mild effects on brain development and survival of control flies, but dramatically shrinks the volumes of experimentally induced neuroblast tumors and significantly extends the lifespan of tumor-bearing animals. This beneficial effect is still observed when Spt5 is knocked down systemically and after tumor initiation, highlighting SPT5 as a potential drug target in human oncology.
The transition to school is a key juncture in an individual’s educational trajectory, with far-reaching effects on the development of children and their families. Successful transitions require flexibility in the design of the transition process, addressing the needs of the persons involved in an adaptive manner. Adaptivity is also considered crucial for the success of inclusive transitions. However, a systematic breakdown of the aspects that characterize the concept of adaptivity in the context of inclusive school entry is not available at this point. This article therefore provides a conceptualization of adaptivity in the inclusive transition to school as well as a review of the current literature focusing this topic. The goal is to develop a model that structures the various aspects of adaptivity at school entry and offers an overview of the way these aspects are important to design the transition successfully according to current findings of empirical research. Building on a concept of transitions informed by ecological systems theory, we are guided by the assumption that adaptivity at transition to school may occur in three forms: as a feature of the persons involved in the transition; as a feature of the processes that moderate the course of the transition; and as a feature of the structures that frame the transition. Based on this distinction, we develop a model that presents adaptivity in the inclusive transition to school.
The binding of drugs to plasma proteins is an important process in the human body and has a significant influence on pharmacokinetic parameter. Human serum albumin (HSA) has the most important function as a transporter protein. The binding of ketamine to HSA has already been described in literature, but only of the racemate. The enantiomerically pure S-ketamine is used as injection solution for induction of anesthesia and has been approved by the Food and Drug Administration for the therapy of severe depression as a nasal spray in 2019. The question arises if there is enantioselective binding to HSA. Hence, the aim of this study was to investigate whether there is enantioselective binding of S-and R-ketamine to HSA or not. Ultrafiltration (UF) followed by chiral capillary electrophoretic analysis was used to determine the extent of protein binding. Bound fraction to HSA was 71.2 % and 64.9 % for enantiomerically pure R- and S-ketamine, respectively, and 66.5 % for the racemate. Detailed binding properties were studied by Saturation Transfer Difference (STD)-, waterLOGSY- and Carr-Purcell-Meiboom-Gill (CPMG)-NMR spectroscopy. With all three methods, the aromatic ring and the N-methyl group could be identified as the structural moieties most strongly involved in binding of ketamine to HSA. pK\(_{aff}\) values determined using UF and NMR indicate that ketamine is a weak affinity ligand to HSA and no significant differences in binding behavior were found between the individual enantiomers and the racemate.
RBM20 mutations account for 3 % of genetic cardiomypathies and manifest with high penetrance and arrhythmogenic effects. Numerous mutations in the conserved RS domain have been described as causing dilated cardiomyopathy (DCM), whereas a particular mutation (p.R634L) drives development of a different cardiac phenotype: left-ventricular non-compaction cardiomyopathy. We generated a mutation-induced pluripotent stem cell (iPSC) line in which the RBM20-LVNC mutation p.R634L was introduced into a DCM patient line with rescued RBM20-p.R634W mutation. These DCM-634L-iPSC can be differentiated into functional cardiomyocytes to test whether this RBM20 mutation induces development of the LVNC phenotype within the genetic context of a DCM patient.
In DNA-encoded library synthesis, amine-substituted building blocks are prevalent. We explored isocyanide multicomponent reactions to diversify DNA-tagged amines and reported the Ugi-azide reaction with high yields and a good substrate scope. In addition, the Ugi-aza-Wittig reaction and the Ugi-4-center-3-component reaction, which used bifunctional carboxylic acids to provide lactams, were explored. Five-, six-, and seven-membered lactams were synthesized from solid support-coupled DNA-tagged amines and bifunctional building blocks, providing access to structurally diverse scaffolds.
Highlights
• Loss of DNAJC19's DnaJ domain disrupts cardiac mitochondrial structure, leading to abnormal cristae formation in iPSC-CMs.
• Impaired mitochondrial structures lead to an increased mitochondrial respiration, ROS and an elevated membrane potential.
• Mutant iPSC-CMs show sarcomere dysfunction and a trend to more arrhythmias, resembling DCMA-associated cardiomyopathy.
Background
Dilated cardiomyopathy with ataxia (DCMA) is an autosomal recessive disorder arising from truncating mutations in DNAJC19, which encodes an inner mitochondrial membrane protein. Clinical features include an early onset, often life-threatening, cardiomyopathy associated with other metabolic features. Here, we aim to understand the metabolic and pathophysiological mechanisms of mutant DNAJC19 for the development of cardiomyopathy.
Methods
We generated induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) of two affected siblings with DCMA and a gene-edited truncation variant (tv) of DNAJC19 which all lack the conserved DnaJ interaction domain. The mutant iPSC-CMs and their respective control cells were subjected to various analyses, including assessments of morphology, metabolic function, and physiological consequences such as Ca\(^{2+}\) kinetics, contractility, and arrhythmic potential. Validation of respiration analysis was done in a gene-edited HeLa cell line (DNAJC19tv\(_{HeLa}\)).
Results
Structural analyses revealed mitochondrial fragmentation and abnormal cristae formation associated with an overall reduced mitochondrial protein expression in mutant iPSC-CMs. Morphological alterations were associated with higher oxygen consumption rates (OCRs) in all three mutant iPSC-CMs, indicating higher electron transport chain activity to meet cellular ATP demands. Additionally, increased extracellular acidification rates suggested an increase in overall metabolic flux, while radioactive tracer uptake studies revealed decreased fatty acid uptake and utilization of glucose. Mutant iPSC-CMs also showed increased reactive oxygen species (ROS) and an elevated mitochondrial membrane potential. Increased mitochondrial respiration with pyruvate and malate as substrates was observed in mutant DNAJC19tv HeLa cells in addition to an upregulation of respiratory chain complexes, while cellular ATP-levels remain the same. Moreover, mitochondrial alterations were associated with increased beating frequencies, elevated diastolic Ca\(^{2+}\) concentrations, reduced sarcomere shortening and an increased beat-to-beat rate variability in mutant cell lines in response to β-adrenergic stimulation.
Conclusions
Loss of the DnaJ domain disturbs cardiac mitochondrial structure with abnormal cristae formation and leads to mitochondrial dysfunction, suggesting that DNAJC19 plays an essential role in mitochondrial morphogenesis and biogenesis. Moreover, increased mitochondrial respiration, altered substrate utilization, increased ROS production and abnormal Ca\(^{2+}\) kinetics provide insights into the pathogenesis of DCMA-related cardiomyopathy.
Background
Healthcare workers and medical students faced new challenges during the COVID-19 pandemic. Processes within many hospitals were completely disrupted. In addition, the face to face teaching of medical students was drastically reduced. Those at risk of developing mental health problems appear to be younger health care workers and women.
Objective
To investigate potential COVID-19 pandemic-related gender differences in psychological distress among medical students and physicians in their first years of practice.
Design and setting
An anonymous survey was carried out online between December 1, 2021, and March 31, 2022, at the Mannheim Medical Faculty and the Würzburg Medical Faculty, Germany, after obtaining informed consent. Primary outcome measures were changes in anxiety and depression symptoms using the Hospital Anxiety and Depression Scale (HADS), and changes in participants' current quality of life using the WHO Quality of Life BREF.
Results
The results show wave-like courses for perceived anxiety and burden overlapping with the course of the COVID-19 incidence. In comparison to men, women showed a significant higher increase in HADS (p = 0.005) and a reduced life quality (p = 0.007) after COVID-19. Both sexes showed different frequencies of the factors influencing quality of life, with the presence of a previous mental illness and mean anxiety having a significant higher negative impact in women.
Conclusion
Future and young female physicians reported a disproportionate higher burden during COVID-19 compared to their male colleges. These observations suggest an increased need for support and prevention efforts especially in this vulnerable population.
Background
Haemophilus influenzae (Hi) is a Gram-negative bacterium that may cause sepsis or meningitis, treatment of which mainly includes β-lactam antibiotics. Since 2019 EUCAST breakpoints for piperacillin/tazobactam have been available. Little is known about the prevalence and mechanisms of piperacillin/tazobactam resistance in Hi.
Objectives
To provide reliable prevalence data for piperacillin/tazobactam resistance in Hi in Germany, to evaluate different antibiotic susceptibility testing methods and to examine possible resistance mechanisms.
Methods
According to EUCAST breakpoints, the MIC for piperacillin/tazobactam resistance is >0.25 mg/L. All invasive Hi in Germany from 2019 were examined by gradient agar diffusion (GAD) for piperacillin/tazobactam susceptibility. Piperacillin/tazobactam broth microdilution (BMD), piperacillin GAD on tazobactam-containing agar [piperacillin GAD on Mueller–Hinton agar with horse blood (MH-F)/tazobactam) and piperacillin/tazobactam agar dilution (AD) were used for confirmation. Phenotypic testing was complemented by ftsI sequencing.
Results
Piperacillin/tazobactam GAD resulted in 2.9% (21/726) resistant Hi. BMD did not confirm piperacillin/tazobactam resistance. Two strains were found resistant by AD, of which one was also resistant using piperacillin GAD on MH-F/tazobactam. Overall, we found two strains with a piperacillin/tazobactam MIC >0.25 mg/L in at least two different tests (0.3%). Both were β-lactamase-producing amoxicillin/clavulanate-resistant with PBP3 mutations characterized as group III-like+. Relevant PBP3 mutations occurred in six strains without phenotypic piperacillin/tazobactam resistance. These mutations suggest a reduced efficacy of β-lactam antibiotics in these isolates.
Conclusions
Piperacillin/tazobactam resistance prevalence in invasive Hi is low in Germany. Reduced susceptibility was correlated with PBP3 mutations, in particular with group III mutations.
Glycine receptor β–targeting autoantibodies contribute to the pathology of autoimmune diseases
(2024)
Background and Objectives
Stiff-person syndrome (SPS) and progressive encephalomyelitis with rigidity and myoclonus (PERM) are rare neurologic disorders of the CNS. Until now, exclusive GlyRα subunit–binding autoantibodies with subsequent changes in function and surface numbers were reported. GlyR autoantibodies have also been described in patients with focal epilepsy. Autoimmune reactivity against the GlyRβ subunits has not yet been shown. Autoantibodies against GlyRα1 target the large extracellular N-terminal domain. This domain shares a high degree of sequence homology with GlyRβ making it not unlikely that GlyRβ-specific autoantibody (aAb) exist and contribute to the disease pathology.
Methods
In this study, we investigated serum samples from 58 patients for aAb specifically detecting GlyRβ. Studies in microarray format, cell-based assays, and primary spinal cord neurons and spinal cord tissue immunohistochemistry were performed to determine specific GlyRβ binding and define aAb binding to distinct protein regions. Preadsorption approaches of aAbs using living cells and the purified extracellular receptor domain were further used. Finally, functional consequences for inhibitory neurotransmission upon GlyRβ aAb binding were resolved by whole-cell patch-clamp recordings.
Results
Among 58 samples investigated, cell-based assays, tissue analysis, and preadsorption approaches revealed 2 patients with high specificity for GlyRβ aAb. Quantitative protein cluster analysis demonstrated aAb binding to synaptic GlyRβ colocalized with the scaffold protein gephyrin independent of the presence of GlyRα1. At the functional level, binding of GlyRβ aAb from both patients to its target impair glycine efficacy.
Discussion
Our study establishes GlyRβ as novel target of aAb in patients with SPS/PERM. In contrast to exclusively GlyRα1-positive sera, which alter glycine potency, aAbs against GlyRβ impair receptor efficacy for the neurotransmitter glycine. Imaging and functional analyses showed that GlyRβ aAbs antagonize inhibitory neurotransmission by affecting receptor function rather than localization.
Highlights
• The GLA variant S126G is not associated with Fabry symptoms in the presented case
• S126G has no effect on α-GAL A activity or Gb3 levels in this patient
• S126G sensory neurons show no electrophysiological abnormalities
Abstract
Fabry disease (FD) is a life-limiting disorder characterized by intracellular globotriaosylceramide (Gb3) accumulations. The underlying α-galactosidase A (α-GAL A) deficiency is caused by variants in the gene GLA. Variants of unknown significance (VUS) are frequently found in GLA and challenge clinical management. Here, we investigated a 49-year old man with cryptogenic lacunar cerebral stroke and the chance finding of the VUS S126G, who was sent to our center for diagnosis and initiation of a costly and life-long FD-specific treatment. We combined clinical examination with in vitro investigations of dermal fibroblasts (HDF), induced pluripotent stem cells (iPSC), and iPSC-derived sensory neurons. We analyzed α-GAL A activity in iPSC, Gb3 accumulation in all three cell types, and action potential firing in sensory neurons. Neurological examination and small nerve fiber assessment was normal except for reduced distal skin innervation. S126G iPSC showed normal α-GAL A activity compared to controls and no Gb3 deposits were found in all three cell types. Baseline electrophysiological characteristics of S126G neurons showed no difference compared to healthy controls as investigated by patch-clamp recordings. We pioneer multi-level cellular characterization of the VUS S126G using three cell types derived from a patient and provide further evidence for the benign nature of S126G in GLA, which is of great importance in the management of such cases in clinical practice.
Introduction:
Fibromyalgia syndrome (FMS) and small fiber neuropathy (SFN) are distinct pain conditions that share commonalities and may be challenging as for differential diagnosis.
Objective:
To comprehensively investigate clinical characteristics of women with FMS and SFN to determine clinically applicable parameters for differentiation.
Methods:
We retrospectively analyzed medical records of 158 women with FMS and 53 with SFN focusing on pain-specific medical and family history, accompanying symptoms, additional diseases, and treatment. We investigated data obtained using standardized pain, depression, and anxiety questionnaires. We further analyzed test results and findings obtained in standardized small fiber tests.
Results:
FMS patients were on average ten years younger at symptom onset, described higher pain intensities requiring frequent change of pharmaceutics, and reported generalized pain compared to SFN. Pain in FMS was accompanied by irritable bowel or sleep disturbances, and in SFN by paresthesias, numbness, and impaired glucose metabolism (P < 0.01 each). Family history was informative for chronic pain and affective disorders in FMS (P < 0.001) and for neurological disorders in SFN patients (P < 0.001). Small fiber pathology in terms of skin denervation and/or thermal sensory threshold elevation was present in 110/158 (69.7 %) FMS patients and 39/53 (73.6 %) SFN patients. FMS patients mainly showed proximally reduced skin innervation and higher corneal nerve branch densities (p<0.001) whereas SFN patients were characterized by reduced cold detection and prolonged electrical A-delta conduction latencies (P < 0.05).
Conclusions:
Our data show that FMS and SFN differ substantially. Detailed pain, drug and family history, investigating blood glucose metabolism, and applying differential small fiber tests may help to improve diagnostic differentiation and targeted therapy.
Background
Complex regional pain syndrome (CRPS) develops after injury and is characterized by disproportionate pain, oedema, and functional loss. CRPS has clinical signs of neuropathy as well as neurogenic inflammation. Here, we asked whether skin biopsies could be used to differentiate the contribution of these two systems to ultimately guide therapy. To this end, the cutaneous sensory system including nerve fibres and the recently described nociceptive Schwann cells as well as the cutaneous immune system were analysed.
Methods
We systematically deep-phenotyped CRPS patients and immunolabelled glabrous skin biopsies from the affected ipsilateral and non-affected contralateral finger of 19 acute (< 12 months) and 6 chronic (> 12 months after trauma) CRPS patients as well as 25 sex- and age-matched healthy controls (HC). Murine foot pads harvested one week after sham or chronic constriction injury were immunolabelled to assess intraepidermal Schwann cells.
Results
Intraepidermal Schwann cells were detected in human skin of the finger—but their density was much lower compared to mice. Acute and chronic CRPS patients suffered from moderate to severe CRPS symptoms and corresponding pain. Most patients had CRPS type I in the warm category. Their cutaneous neuroglial complex was completely unaffected despite sensory plus signs, e.g. allodynia and hyperalgesia. Cutaneous innate sentinel immune cells, e.g. mast cells and Langerhans cells, infiltrated or proliferated ipsilaterally independently of each other—but only in acute CRPS. No additional adaptive immune cells, e.g. T cells and plasma cells, infiltrated the skin.
Conclusions
Diagnostic skin punch biopsies could be used to diagnose individual pathophysiology in a very heterogenous disease like acute CRPS to guide tailored treatment in the future. Since numbers of inflammatory cells and pain did not necessarily correlate, more in-depth analysis of individual patients is necessary.
Emotional dysregulation and its pathways to suicidality in a community-based sample of adolescents
(2024)
Objective
Effective suicide prevention for adolescents is urgently needed but difficult, as suicide models lack a focus on age-specific influencing factors such as emotional dysregulation. Moreover, examined predictors often do not specifically consider the contribution to the severity of suicidality.
To determine which adolescents are at high risk of more severe suicidality, we examined the association between emotional dysregulation and severity of suicidality directly as well as indirectly via depressiveness and nonsuicidal self-injury.
Method
Adolescents from 18 high schools in Bavaria were included in this cross-sectional and questionnaire-based study as part of a larger prevention study. Data were collected between November 2021 and March 2022 and were analyzed from January 2023 to April 2023.
Students in the 6th or 7th grade of high school (11–14 years) were eligible to participate. A total of 2350 adolescents were surveyed and data from 2117 students were used for the analyses after excluding incomplete data sets. Our main outcome variable was severity of suicidality (Paykel Suicide Scale, PSS). Additionally, we assessed emotional dysregulation (Difficulties in Emotion Regulation Scale, DERS-SF), depressiveness (Patient Health Questionnaire, PHQ-9) and nonsuicidal self-injury (Deliberate Self-Harm Inventory, DSHI).
Results
In total, 2117 adolescents (51.6% female; mean age, 12.31 years [standard deviation: 0.67]) were included in the structural equation model (SEM). Due to a clear gender-specific influence, the model was calculated separately for male and female adolescents. For male adolescents, there was a significant indirect association between emotional dysregulation and severity of suicidality, mediated by depressiveness (β = 0.15, SE = .03, p = .008). For female adolescents, there was a significant direct path from emotional dysregulation to severity of suicidality and also indirect paths via depressiveness (β = 0.12, SE = .05, p = 0.02) and NSSI (β = 0.18, SE = .04, p < .001).
Conclusions
Our results suggest that gender-related risk markers in 11–14-year-olds need to be included in future suicide models to increase their predictive power. According to our findings, early detection and prevention interventions based on emotion regulation skills might be enhanced by including gender-specific adjustments for the co-occurrence of emotional dysregulation, depressiveness, and nonsuicidal self-injury in girls and the co-occurrence of emotional dysregulation and depressiveness in boys.
Background
Iron deficiency (ID) is the leading cause of anemia worldwide. The prevalence of preoperative ID ranges from 23 to 33%. Preoperative anemia is associated with worse outcomes, making it important to diagnose and treat ID before elective surgery. Several studies indicated the effectiveness of intravenous iron supplementation in iron deficiency with or without anemia (ID(A)). However, it remains challenging to establish reliable evidence due to heterogeneity in utilized study outcomes. The development of a core outcome set (COS) can help to reduce this heterogeneity by proposing a minimal set of meaningful and standardized outcomes. The aim of our systematic review was to identify and assess outcomes reported in randomized controlled trials (RCTs) and observational studies investigating iron supplementation in iron-deficient patients with or without anemia.
Methods
We searched MEDLINE, CENTRAL, and ClinicalTrials.gov systematically from 2000 to April 1, 2022. RCTs and observational studies investigating iron supplementation in patients with a preoperative diagnosis of ID(A), were included. Study characteristics and reported outcomes were extracted. Outcomes were categorized according to an established outcome taxonomy. Quality of outcome reporting was assessed with a pre-specified tool. Reported clinically relevant differences for sample size calculation were extracted.
Results
Out of 2898 records, 346 underwent full-text screening and 13 studies (five RCTs, eight observational studies) with sufficient diagnostic inclusion criteria for iron deficiency with or without anemia (ID(A)) were eligible. It is noteworthy to mention that 49 studies were excluded due to no confirmed diagnosis of ID(A). Overall, 111 outcomes were structured into five core areas including nine domains. Most studies (92%) reported outcomes within the ‘blood and lymphatic system’ domain, followed by “adverse event” (77%) and “need for further resources” (77%). All of the latter reported on the need for blood transfusion. Reported outcomes were heterogeneous in measures and timing. Merely, two (33%) of six prospective studies were registered prospectively of which one (17%) showed no signs of selective outcome reporting.
Conclusion
This systematic review comprehensively depicts the heterogeneity of reported outcomes in studies investigating iron supplementation in ID(A) patients regarding exact definitions and timing. Our analysis provides a systematic base for consenting to a minimal COS.
Systematic review registration
PROSPERO CRD42020214247
The cystine/glutamate antiporter xCT is an important source of cysteine for cancer cells. Once taken up, cystine is reduced to cysteine and serves as a building block for the synthesis of glutathione, which efficiently protects cells from oxidative damage and prevents ferroptosis. As melanomas are particularly exposed to several sources of oxidative stress, we investigated the biological role of cysteine and glutathione supply by xCT in melanoma. xCT activity was abolished by genetic depletion in the Tyr::CreER; Braf\(^{CA}\); Pten\(^{lox/+}\) melanoma model and by acute cystine withdrawal in melanoma cell lines. Both interventions profoundly impacted melanoma glutathione levels, but they were surprisingly well tolerated by murine melanomas in vivo and by most human melanoma cell lines in vitro. RNA sequencing of human melanoma cells revealed a strong adaptive upregulation of NRF2 and ATF4 pathways, which orchestrated the compensatory upregulation of genes involved in antioxidant defence and de novo cysteine biosynthesis. In addition, the joint activation of ATF4 and NRF2 triggered a phenotypic switch characterized by a reduction of differentiation genes and induction of pro-invasive features, which was also observed after erastin treatment or the inhibition of glutathione synthesis. NRF2 alone was capable of inducing the phenotypic switch in a transient manner. Together, our data show that cystine or glutathione levels regulate the phenotypic plasticity of melanoma cells by elevating ATF4 and NRF2.
Conspectus
Nature has established a sustainable way to maintain aerobic life on earth by inventing one of the most sophisticated biological processes, namely, natural photosynthesis, which delivers us with organic matter and molecular oxygen derived from the two abundant resources sunlight and water. The thermodynamically demanding photosynthetic water splitting is catalyzed by the oxygen-evolving complex in photosystem II (OEC-PSII), which comprises a distorted tetramanganese–calcium cluster (CaMn\(_4\)O\(_5\)) as catalytic core. As an ubiquitous concept for fine-tuning and regulating the reactivity of the active site of metalloenzymes, the surrounding protein domain creates a sophisticated environment that promotes substrate preorganization through secondary, noncovalent interactions such as hydrogen bonding or electrostatic interactions. Based on the high-resolution X-ray structure of PSII, several water channels were identified near the active site, which are filled with extensive hydrogen-bonding networks of preorganized water molecules, connecting the OEC with the protein surface. As an integral part of the outer coordination sphere of natural metalloenzymes, these channels control the substrate and product delivery, carefully regulate the proton flow by promoting pivotal proton-coupled electron transfer processes, and simultaneously stabilize short-lived oxidized intermediates, thus highlighting the importance of an ordered water network for the remarkable efficiency of the natural OEC.
Transferring this concept from nature to the engineering of artificial metal catalysts for fuel production has fostered the fascinating field of metallosupramolecular chemistry by generating defined cavities that conceptually mimic enzymatic pockets. However, the application of supramolecular approaches to generate artificial water oxidation catalysts remained scarce prior to our initial reports, since such molecular design strategies for efficient activation of substrate water molecules in confined nanoenvironments were lacking. In this Account, we describe our research efforts on combining the state-of-the art Ru(bda) catalytic framework with structurally programmed ditopic ligands to guide the water oxidation process in defined metallosupramolecular assemblies in spatial proximity. We will elucidate the governing factors that control the quality of hydrogen-bonding water networks in multinuclear cavities of varying sizes and geometries to obtain high-performance, state-of-the-art water oxidation catalysts. Pushing the boundaries of artificial catalyst design, embedding a single catalytic Ru center into a well-defined molecular pocket enabled sophisticated water preorganization in front of the active site through an encoded basic recognition site, resulting in high catalytic rates comparable to those of the natural counterpart OEC-PSII.
To fully explore their potential for solar fuel devices, the suitability of our metallosupramolecular assemblies was demonstrated under (electro)chemical and photocatalytic water oxidation conditions. In addition, testing the limits of structural diversity allowed the fabrication of self-assembled linear coordination oligomers as novel photocatalytic materials and long-range ordered covalent organic framework (COF) materials as recyclable and long-term stable solid-state materials for future applications.
The reversible condensation of catechols and boronic acids to boronate esters is a paradigm reaction in dynamic covalent chemistry. However, facile backward hydrolysis is detrimental for stability and has so far prevented applications for boronate-based materials. Here, we introduce cubic boronate ester cages 6 derived from hexahydroxy tribenzotriquinacenes and phenylene diboronic acids with ortho-t-butyl substituents. Due to steric shielding, dynamic exchange at the Lewis acidic boron sites is feasible only under acid or base catalysis but fully prevented at neutral conditions. For the first time, boronate ester cages 6 tolerate substantial amounts of water or alcohols both in solution and solid state. The unprecedented applicability of these materials under ambient and aqueous conditions is showcased by efficient encapsulation and on-demand release of β-carotene dyes and heterogeneous water oxidation catalysis after the encapsulation of ruthenium catalysts.
This study investigates the sense of agency (SoA) for saccades with implicit and explicit agency measures. In two eye tracking experiments, participants moved their eyes towards on-screen stimuli that subsequently changed color. Participants then either reproduced the temporal interval between saccade and color-change (Experiment 1) or reported the time points of these events with an auditory Libet clock (Experiment 2) to measure temporal binding effects as implicit indices of SoA. Participants were either made to believe to exert control over the color change or not (agency manipulation). Explicit ratings indicated that the manipulation of causal beliefs and hence agency was successful. However, temporal binding was only evident for caused effects, and only when a sufficiently sensitive procedure was used (auditory Libet clock). This suggests a feebler connection between temporal binding and SoA than previously proposed. The results also provide evidence for a relatively fast acquisition of sense of agency for previously never experienced types of action-effect associations. This indicates that the underlying processes of action control may be rooted in more intricate and adaptable cognitive models than previously thought. Oculomotor SoA as addressed in the present study presumably represents an important cognitive foundation of gaze-based social interaction (social sense of agency) or gaze-based human-machine interaction scenarios.
Public significance statement: In this study, sense of agency for eye movements in the non-social domain is investigated in detail, using both explicit and implicit measures. Therefore, it offers novel and specific insights into comprehending sense of agency concerning effects induced by eye movements, as well as broader insights into agency pertaining to entirely newly acquired types of action-effect associations. Oculomotor sense of agency presumably represents an important cognitive foundation of gaze-based social interaction (social agency) or gaze-based human-machine interaction scenarios. Due to peculiarities of the oculomotor domain such as the varying degree of volitional control, eye movements could provide new information regarding more general theories of sense of agency in future research.
Safety and tolerability of SGLT2 inhibitors in cardiac amyloidosis — a clinical feasibility study
(2024)
Sodium-glucose transport protein 2 inhibitors (SGLT2i) slow the progression of renal dysfunction and improve the prognosis of patients with heart failure. Amyloidosis constitutes an important subgroup for which evidence is lacking. Amyloidotic fibrils originating from misfolded transthyretin and light chains are the causal agents in ATTR and AL amyloidosis. In these most frequent subtypes, cardiac involvement is the most common organ manifestation. Because cardiac and renal function frequently deteriorate over time, even under best available treatment, SGLT2i emerge as a promising treatment option due to their reno- and cardioprotective properties. We retrospectively analyzed patients with cardiac amyloidosis, who received either dapagliflozin or empagliflozin. Out of 79 patients, 5.1% had urinary tract infections; 2 stopped SGLT2i therapy; and 2.5% died unrelated to the intake of SGLT2i. No genital mycotic infections were observed. As expected, a slight drop in the glomerular filtration rate was noted, while the NYHA functional status, cardiac and hepatic function, as well as the 6 min walk distance remained stable over time. These data provide a rationale for the use of SGLT2i in patients with amyloidosis and concomitant cardiac or renal dysfunction. Prospective randomized data are desired to confirm safety and to prove efficacy in this increasingly important group of patients.
AbstractWater oxidation catalysis is a key step for sustainable fuel production by water splitting into hydrogen and oxygen. The synthesis of a novel coordination oligomer based on four Ru(bda) (bda = 2,2′‐bipyridine‐6,6′‐dicarboxylate) centers, three 4,4′‐bipyridine (4,4′‐bpy) linkers, and two 4‐picoline (4‐pic) end caps is reported. The monodispersity of this tetranuclear compound is characterized by NMR techniques. Heterogeneous electrochemical water oxidation after immobilization on multi‐walled carbon nanotubes (MWCNTs) shows catalytic performance unprecedented for this compound class, with a turnover frequency (TOF) of 133 s\(^{−1}\) and a turnover number (TON) of 4.89 × 10\(^6\), at a current density of 43.8 mA cm\(^{−2}\) and a potential of 1.45 V versus normal hydrogen electrode (NHE).
Interpreting gaze behavior is essential in evaluating interaction partners, yet the ‘semantics of gaze’ in dynamic interactions are still poorly understood. We aimed to comprehensively investigate effects of gaze behavior patterns in different conversation contexts, using a two-step, qualitative-quantitative procedure. Participants watched video clips of single persons listening to autobiographic narrations by another (invisible) person. The listener’s gaze behavior was manipulated in terms of gaze direction, frequency and direction of gaze shifts, and blink frequency; emotional context was manipulated through the valence of the narration (neutral/negative). In Experiment 1 (qualitative-exploratory), participants freely described which states and traits they attributed to the listener in each condition, allowing us to identify relevant aspects of person perception and to construct distinct rating scales that were implemented in Experiment 2 (quantitative-confirmatory). Results revealed systematic and differential meanings ascribed to the listener’s gaze behavior. For example, rapid blinking and fast gaze shifts were rated more negatively (e.g., restless and unnatural) than slower gaze behavior; downward gaze was evaluated more favorably (e.g., empathetic) than other gaze aversion types, especially in the emotionally negative context. Overall, our study contributes to a more systematic understanding of flexible gaze semantics in social interaction.
Background
Chronic stress is detrimental to health, and children and young people have had to cope with significantly more stress since the start of the COVID-19 pandemic. In particular, stress at school and in relation to learning is a major problem in this age group. Studies in Germany have indicated that the pandemic has led to a reduced quality of life (QoL) and an increased risk for psychiatric disorders in children and adolescents. Schools are an ideal setting for interventions against stress, which is one of the strongest predictors for the development of psychosocial problems. The present study seeks to address stress by means of a short prevention training programme in schools, including emotion regulation, mindfulness, and self-compassion. In addition to information material for self-study, students should have the opportunity to actively deal with the topic of stress and develop coping strategies within a short space of time. In contrast to very long stress reduction programmes that often last several weeks, the programme is delivered in just 90 min.
Methods
The effectiveness of the short and economical prevention programme LessStress will be examined in a cluster-randomised controlled trial (RCT) encompassing 1894 students. At several measurement time points, students from two groups (intervention and control) will be asked about their subjectively perceived stress levels, among other aspects. Due to the clustered nature of the data, mainly multilevel analyses will be performed.
Discussion
In Germany, there are no nationwide universal prevention programmes for students against stress in schools, and this gap has become more evident since the outbreak of the pandemic. Universal stress prevention in schools may be a starting point to promote resilience. By dealing with stress in a healthy way, mental health can be strengthened and maintained. Moreover, to reach at-risk students at an early stage, we advocate for a stronger networking between child psychiatry and schools.
In the scientific search for truth, the correspondence theory is predominant to decipher what counts as true. In this approach, scientific knowledge becomes empirically demonstrable and thus enclosed to the sphere of immanence. However, in theology’s approach to question the given status of being human and the world’s development as creation, theology does not adhere to answers that are contained within the sphere of demonstrable knowledge or mundanity, and thereby theology presents a fundamentally different conception of truth, Jesus Christ the living truth. In opposition to drawing on empirical proof, I want to reread Christian theology in a Socratic manner that employs irony to question overly simple methodologies and seek further insights what it means to be human and be engaged in the scientific search for truth if the authority of knowledge does not lie within humanity’s grasp. In doing so, theology’s role is an annoying, yet necessary irritation within the field of today’s academia.
Background
The role of cytokines in the pathophysiology, diagnosis, and prognosis of small fiber neuropathy (SFN) is incompletely understood. We studied expression profiles of selected pro- and anti-inflammatory cytokines in RNA from white blood cells (WBC) of patients with a medical history and a clinical phenotype suggestive for SFN and compared data with healthy controls.
Methods
We prospectively recruited 52 patients and 21 age- and sex-matched healthy controls. Study participants were characterized in detail and underwent complete neurological examination. Venous blood was drawn for routine and extended laboratory tests, and for WBC isolation. Systemic RNA expression profiles of the pro-inflammatory cytokines interleukin (IL)-1ß, IL-2, IL-8, tumor necrosis factor-alpha (TNF) and the anti-inflammatory cytokines IL-4, IL-10, transforming growth factor beta-1 (TGF) were analyzed. Protein levels of IL-2, IL-8, and TNF were measured in serum of patients and controls. Receiver operating characteristic (ROC)-curve analysis was used to determine the accuracy of IL-2, IL-8, and TNF in differentiating patients and controls. To compare the potential discriminatory efficacy of single versus combined cytokines, equality of different AUCs was tested.
Results
WBC gene expression of IL-2, IL-8, and TNF was higher in patients compared to healthy controls (IL-2: p = 0.02; IL-8: p = 0.009; TNF: p = 0.03) and discriminated between the groups (area under the curve (AUC) ≥ 0.68 for each cytokine) with highest diagnostic accuracy reached by combining the three cytokines (AUC = 0.81, sensitivity = 70%, specificity = 86%). Subgroup analysis revealed the following differences: IL-8 and TNF gene expression levels were higher in female patients compared to female controls (IL-8: p = 0.01; TNF: p = 0.03). The combination of TNF with IL-2 and TNF with IL-2 and IL-8 discriminated best between the study groups. IL-2 was higher expressed in patients with moderate pain compared to those with severe pain (p = 0.02). Patients with acral pain showed higher IL-10 gene expression compared to patients with generalized pain (p = 0.004). We further found a negative correlation between the relative gene expression of IL-2 and current pain intensity (p = 0.02). Serum protein levels of IL-2, IL-8, and TNF did not differ between patients and controls.
Conclusions
We identified higher systemic gene expression of IL-2, IL-8, and TNF in SFN patients than in controls, which may be of potential relevance for diagnostics and patient stratification.
In 1747, an important milestone in the history of clinical research was set, as the Scottish surgeon James Lind conducted the first randomized controlled trial. Lind was interested in scurvy, a severe vitamin C deficiency which caused the death of thousands of British seamen. He found that a dietary intervention with oranges and lemons, which are rich in vitamin C by nature, was effective to recover from scurvy. Because of its antioxidative properties and involvement in many biochemical processes, the essential micronutrient vitamin C plays a key role in the human biology. Moreover, the use of vitamin C in critical illness—a condition also resulting in death of thousands in the 21st century—has gained increasing interest, as it may restore vascular responsiveness to vasoactive agents, ameliorate microcirculatory blood flow, preserve endothelial barriers, augment bacterial defense, and prevent apoptosis. Because of its redox potential and powerful antioxidant capacity, vitamin C represents an inexpensive and safe antioxidant, with the potential to modify the inflammatory cascade and improve clinical outcomes of critically ill patients. This narrative review aims to update and provide an overview on the role of vitamin C in the human biology and in critically ill patients, and to summarize current evidence on the use of vitamin C in diverse populations of critically ill patients, in specific focusing on patients with sepsis and coronavirus disease 2019.
The phylogeny of Euglenophyceae (Euglenozoa, Euglenida) has been discussed for decades with new genera being described in the last few years. In this study, we reconstruct a phylogeny using 18S rDNA sequence and structural data simultaneously. Using homology modeling, individual secondary structures were predicted. Sequence–structure data are encoded and automatically aligned. Here, we present a sequence–structure neighbor‐joining tree of more than 300 taxa classified as Euglenophyceae. Profile neighbor‐joining was used to resolve the basal branching pattern. Neighbor‐joining, maximum parsimony, and maximum likelihood analyses were performed using sequence–structure information for manually chosen subsets. All analyses supported the monophyly of Eutreptiella, Discoplastis, Lepocinclis, Strombomonas, Cryptoglena, Monomorphina, Euglenaria, and Colacium. Well‐supported topologies were generally consistent with previous studies using a combined dataset of genetic markers. Our study supports the simultaneous use of sequence and structural data to reconstruct more accurate and robust trees. The average bootstrap value is significantly higher than the average bootstrap value obtained from sequence‐only analyses, which is promising for resolving relationships between more closely related taxa.
Despite sometimes strong codependencies of insect herbivores and plants, the responses of individual taxa to accelerating climate change are typically studied in isolation. For this reason, biotic interactions that potentially limit species in tracking their preferred climatic niches are ignored. Here, we chose butterflies as a prominent representative of herbivorous insects to investigate the impacts of temperature changes and their larval host plant distributions along a 1.4‐km elevational gradient in the German Alps. Following a sampling protocol of 2009, we revisited 33 grassland plots in 2019 over an entire growing season. We quantified changes in butterfly abundance and richness by repeated transect walks on each plot and disentangled the direct and indirect effects of locally assessed temperature, site management, and larval and adult food resource availability on these patterns. Additionally, we determined elevational range shifts of butterflies and host plants at both the community and species level. Comparing the two sampled years (2009 and 2019), we found a severe decline in butterfly abundance and a clear upward shift of butterflies along the elevational gradient. We detected shifts in the peak of species richness, community composition, and at the species level, whereby mountainous species shifted particularly strongly. In contrast, host plants showed barely any change, neither in connection with species richness nor individual species shifts. Further, temperature and host plant richness were the main drivers of butterfly richness, with change in temperature best explaining the change in richness over time. We concluded that host plants were not yet hindering butterfly species and communities from shifting upwards. However, the mismatch between butterfly and host plant shifts might become a problem for this very close plant–herbivore relationship, especially toward higher elevations, if butterflies fail to adapt to new host plants. Further, our results support the value of conserving traditional extensive pasture use as a promoter of host plant and, hence, butterfly richness.
Earlier flowering of winter oilseed rape compensates for higher pest pressure in warmer climates
(2023)
Global warming can increase insect pest pressure by enhancing reproductive rates. Whether this translates into yield losses depends on phenological synchronisation of pests with their host plants and natural enemies. Simultaneously, landscape composition may mitigate climate effects by shaping the resource availability for pests and their antagonists. Here, we study the combined effects of temperature and landscape composition on pest abundances, larval parasitism, crop damage and yield, while also considering crop phenology, to identify strategies for sustainable management of oilseed rape (OSR) pests under warming climates.
In all, 29 winter OSR crop fields were investigated in different climates (defined by multi‐annual mean temperature, MAT) and landscape contexts in Bavaria, Germany. We measured abundances of adult pollen beetles and stem weevil larvae, pollen beetle larval parasitism, bud loss, stem damage and seed yield, and calculated the flowering date from growth stage observations. Landscape parameters (proportion of non‐crop and OSR area, change in OSR area relative to the previous year) were calculated at six spatial scales (0.6–5 km).
Pollen beetle abundance increased with MAT but to different degrees depending on the landscape context, that is, increased less strongly when OSR proportions were high (1‐km scale), interannually constant (5‐km scale) or both. In contrast, stem weevil abundance and stem damage did not respond to landscape composition nor MAT. Pollen beetle larval parasitism was overall low, but occasionally exceeded 30% under both low and high MAT and with reduced OSR area (0.6‐km scale).
Despite high pollen beetle abundance in warm climates, yields were high when OSR flowered early. Thereby, higher temperatures favoured early flowering. Only among late‐flowering OSR crop fields yield was higher in cooler than warmer climates. Bud loss responded analogously. Landscape composition did not substantially affect bud loss and yield.
Synthesis and applications: Earlier flowering of winter OSR compensates for higher pollen beetle abundance in warmer climates, while interannual continuity of OSR area prevents high pollen beetle abundance in the first place. Thus, regional coordination of crop rotation and crop management promoting early flowering may contribute to sustainable pest management in OSR under current and future climatic conditions.
Humans have long used external memory aids to support remembering. However, modern digital technologies could facilitate recording and remembering personal information in an unprecedented manner. The present research sought to understand the potential impact of these technologies on autobiographical memory based on interviews with users of smart journaling apps. In Study 1 (N = 12), participants who had no prior experience with smart journaling apps tested the app Day One for 2 weeks and were interviewed about their subjective perceptions afterwards. In order to cross-validate the obtained findings, Study 2 (N = 4) was based on in-depth interviews with long-time users of different smart journaling apps. Taken together, the two studies provide insights into the way autobiographical remembering may change in the digital age – but also into the opportunities and risks potentially associated with the use of technologies that allow creating a detailed and multimedia-based record of one's life.
Introduction
Medium-cut-off (MCO) dialyzers may beneficially impact outcomes in patients on hemodialysis.
Methods
In a randomized, controlled trial in maintenance hemodialysis patients, the new Nipro ELISIO-17HX MCO dialyzer was compared to the Baxter Theranova 400 filter regarding middle molecule removal. Furthermore, the suitability of two assays for free lambda-light chain (λFLC) detection (Freelite vs. N-Latex) was verified.
Results
ELISIO-HX achieved slightly lower reduction ratios for β2-microglobulin (71.8 ± 6.0 vs. 75.3 ± 5.8%; p = 0.001), myoglobin (54.7 ± 8.6 vs. 64.9 ± 8.7%; p < 0.001), and kappa-FLC (62.1 ± 8.8 vs. 56.3 ± 7.7%; p = 0.021). λFLC reduction ratios were more conclusive with the Freelite assay and not different between ELISIO-HX and Theranova (28.4 ± 3.9 vs. 38.7 ± 13.4%; p = 0.069). The albumin loss of Theranova was considerably higher (2.14 ± 0.45 vs. 0.77 ± 0.25 g; p = 0.001) and the Global Removal ScoreLoss alb largely inferior (30.6 ± 7.4 vs. 82.4 ± 29.2%/g; p = 0.006) to ELISIO-HX.
Conclusions
The new ELISIO-HX expands the choice of dialyzers for MCO hemodialysis.
Salt stress is a major abiotic stress, responsible for declining agricultural productivity. Roots are regarded as hubs for salt detoxification, however, leaf salt concentrations may exceed those of roots. How mature leaves manage acute sodium chloride (NaCl) stress is mostly unknown.
To analyze the mechanisms for NaCl redistribution in leaves, salt was infiltrated into intact tobacco leaves. It initiated pronounced osmotically‐driven leaf movements. Leaf downward movement caused by hydro‐passive turgor loss reached a maximum within 2 h.
Salt‐driven cellular water release was accompanied by a transient change in membrane depolarization but not an increase in cytosolic calcium ion (Ca\(^{2+}\)) level. Nonetheless, only half an hour later, the leaves had completely regained turgor. This recovery phase was characterized by an increase in mesophyll cell plasma membrane hydrogen ion (H\(^{+}\)) pumping, a salt uptake‐dependent cytosolic alkalization, and a return of the apoplast osmolality to pre‐stress levels. Although, transcript numbers of abscisic acid‐ and Salt Overly Sensitive pathway elements remained unchanged, salt adaptation depended on the vacuolar H\(^{+}\)/Na\(^{+}\)‐exchanger NHX1.
Altogether, tobacco leaves can detoxify sodium ions (Na\(^{+}\)) rapidly even under massive salt loads, based on pre‐established posttranslational settings and NHX1 cation/H+ antiport activity. Unlike roots, signaling and processing of salt stress in tobacco leaves does not depend on Ca\(^{2+}\) signaling.
Formation of the Aurora-A–MYCN complex increases levels of the oncogenic transcription factor MYCN in neuroblastoma cells by abrogating its degradation through the ubiquitin proteasome system. While some small-molecule inhibitors of Aurora-A were shown to destabilize MYCN, clinical trials have not been satisfactory to date. MYCN itself is considered to be `undruggable' due to its large intrinsically disordered regions. Targeting the Aurora-A–MYCN complex rather than Aurora-A or MYCN alone will open new possibilities for drug development and screening campaigns. To overcome the challenges that a ternary system composed of Aurora-A, MYCN and a small molecule entails, a covalently cross-linked construct of the Aurora-A–MYCN complex was designed, expressed and characterized, thus enabling screening and design campaigns to identify selective binders.
To evaluate an iterative learning approach for enhanced performance of robust artificial‐neural‐networks for k‐space interpolation (RAKI), when only a limited amount of training data (auto‐calibration signals [ACS]) are available for accelerated standard 2D imaging.
Methods
In a first step, the RAKI model was tailored for the case of limited training data amount. In the iterative learning approach (termed iterative RAKI [iRAKI]), the tailored RAKI model is initially trained using original and augmented ACS obtained from a linear parallel imaging reconstruction. Subsequently, the RAKI convolution filters are refined iteratively using original and augmented ACS extracted from the previous RAKI reconstruction. Evaluation was carried out on 200 retrospectively undersampled in vivo datasets from the fastMRI neuro database with different contrast settings.
Results
For limited training data (18 and 22 ACS lines for R = 4 and R = 5, respectively), iRAKI outperforms standard RAKI by reducing residual artifacts and yields better noise suppression when compared to standard parallel imaging, underlined by quantitative reconstruction quality metrics. Additionally, iRAKI shows better performance than both GRAPPA and standard RAKI in case of pre‐scan calibration with varying contrast between training‐ and undersampled data.
Conclusion
RAKI benefits from the iterative learning approach, which preserves the noise suppression feature, but requires less original training data for the accurate reconstruction of standard 2D images thereby improving net acceleration.
Activation of Ge−H and Sn−H Bonds with N‐Heterocyclic Carbenes and a Cyclic (Alkyl)(amino)carbene
(2023)
A study of the reactivity of several N‐heterocyclic carbenes (NHCs) and the cyclic (alkyl)(amino)carbene 1‐(2,6‐di‐iso‐propylphenyl)‐3,3,5,5‐tetramethyl‐pyrrolidin‐2‐ylidene (cAAC\(^{Me}\)) with the group 14 hydrides GeH2Mes2 and SnH2Me2 (Me=CH\(_{3}\), Mes=1,3,5‐(CH\(_{3}\))\(_{3}\)C\(_{6}\)H\(_{2}\)) is presented. The reaction of GeH\(_{2}\)Mes\(_{2}\) with cAAC\(^{Me}\) led to the insertion of cAAC\(^{Me}\) into one Ge−H bond to give cAAC\(^{Me}\)H−GeHMes\(_{2}\) (1). If 1,3,4,5‐tetramethyl‐imidazolin‐2‐ylidene (Me\(_{2}\)Im\(^{Me}\)) was used as the carbene, NHC‐mediated dehydrogenative coupling occurred, which led to the NHC‐stabilized germylene Me\(_{2}\)Im\(^{Me}\)⋅GeMes\(_{2}\) (2). The reaction of SnH\(_{2}\)Me\(_{2}\) with cAAC\(^{Me}\) also afforded the insertion product cAAC\(^{Me}\)H−SnHMe\(_{2}\) (3), and reaction of two equivalents Me\(_{2}\)Im\(^{Me}\) with SnH\(_{2}\)Me\(_{2}\) gave the NHC‐stabilized stannylene Me\(_{2}\)Im\(^{Me}\)⋅SnMe\(_{2}\) (4). If the sterically more demanding NHCs Me\(_{2}\)Im\(^{Me}\), 1,3‐di‐isopropyl‐4,5‐dimethyl‐imidazolin‐2‐ylidene (iPr\(_{2}\)Im\(^{Me}\)) and 1,3‐bis‐(2,6‐di‐isopropylphenyl)‐imidazolin‐2‐ylidene (Dipp\(_{2}\)Im) were employed, selective formation of cyclic oligomers (SnMe\(_{2}\))\(_{n}\) (5; n=5–8) in high yield was observed. These cyclic oligomers were also obtained from the controlled decomposition of cAAC\(^{Me}\)H−SnHMe\(_{2}\) (3).
Amber Light Control of Peptide Secondary Structure by a Perfluoroaromatic Azobenzene Photoswitch
(2023)
The incorporation of photoswitches into the molecular structure of peptides and proteins enables their dynamic photocontrol in complex biological systems. Here, a perfluorinated azobenzene derivative triggered by amber light was site‐specifically conjugated to cysteines in a helical peptide by perfluoroarylation chemistry. In response to the photoisomerization (trans→cis) of the conjugated azobenzene with amber light, the secondary structure of the peptide was modulated from a disorganized into an amphiphilic helical structure.
The development of ligands capable of effectively stabilizing highly reactive main‐group species has led to the experimental realization of a variety of systems with fascinating properties. In this work, we computationally investigate the electronic, structural, energetic, and bonding features of proximity‐enforced group 13–15 homodimers stabilized by a rigid expanded pincer ligand based on the 1,8‐naphthyridine (napy) core. We show that the redox‐active naphthyridine diimine (NDI) ligand enables a wide variety of structural motifs and element‐element interaction modes, the latter ranging from isolated, element‐centered lone pairs (e.g., E = Si, Ge) to cases where through‐space π bonds (E = Pb), element‐element multiple bonds (E = P, As) and biradical ground states (E = N) are observed. Our results hint at the feasibility of NDI‐E2 species as viable synthetic targets, highlighting the versatility and potential applications of napy‐based ligands in main‐group chemistry.
The 2‐aryl‐3,4,5,6‐tetraphenyl‐1,2‐azaborinines 1‐EMe\(_{3}\) and 2‐EMe\(_{3}\) (E=Si, Sn; aryl=Ph (1), Mes (=2,4,6‐trimethylphenyl, 2)) were synthesized by ring‐expansion of borole precursors with N\(_{3}\)EMe\(_{3}\)‐derived nitrenes. Desilylative hydrolysis of 1‐ and 2‐SiMe\(_{3}\) yielded the corresponding N‐protonated azaborinines, which were deprotonated with nBuLi or MN(SiMe\(_{3}\))\(_{2}\) (M=Na, K) to the corresponding group 1 salts, 1‐M and 2‐M. While the lithium salts crystallized as monomeric Lewis base adducts, the potassium salts formed coordination polymers or oligomers via intramolecular K⋅⋅⋅aryl π interactions. The reaction of 1‐M or 2‐M with CO\(_{2}\) yielded N‐carboxylate salts, which were derivatized by salt metathesis to methyl and silyl esters. Salt metathesis of 1‐M or 2‐M with methyl triflate, [Cp*BeCl] (Cp*=C\(_{5}\)Me\(_{5}\)), BBr\(_{2}\)Ar (Ar=Ph, Mes, 2‐thienyl), ECl\(_{3}\) (E=B, Al, Ga) and PX\(_{3}\) (X=Cl, Br) afforded the respective group 2, 13 and 15 1,2‐azaborinin‐2‐yl complexes. Salt metathesis of 1‐K with BBr\(_{3}\) resulted not only in N‐borylation but also Ph‐Br exchange between the endocyclic and exocyclic boron atoms. Solution \(^{11}\)B NMR data suggest that the 1,2‐azaborinin‐2‐yl ligand is similarly electron‐withdrawing to a bromide. In the solid state the endocyclic bond length alternation and the twisting of the C\(_{4}\)BN ring increase with the sterics of the substituents at the boron and nitrogen atoms, respectively. Regression analyses revealed that the downfield shift of the endocyclic \(^{11}\)B NMR resonances is linearly correlated to both the degree of twisting of the C\(_{4}\)BN ring and the tilt angle of the N‐substituent. Calculations indicate that the 1,2‐azaborinin‐1‐yl ligand has no sizeable π‐donor ability and that the aromaticity of the ring can be subtly tuned by the electronics of the N‐substituent.
The signal modelling framework JimenaE simulates dynamically Boolean networks. In contrast to SQUAD, there is systematic and not just heuristic calculation of all system states. These specific features are not present in CellNetAnalyzer and BoolNet. JimenaE is an expert extension of Jimena, with new optimized code, network conversion into different formats, rapid convergence both for system state calculation as well as for all three network centralities. It allows higher accuracy in determining network states and allows to dissect networks and identification of network control type and amount for each protein with high accuracy. Biological examples demonstrate this: (i) High plasticity of mesenchymal stromal cells for differentiation into chondrocytes, osteoblasts and adipocytes and differentiation-specific network control focusses on wnt-, TGF-beta and PPAR-gamma signaling. JimenaE allows to study individual proteins, removal or adding interactions (or autocrine loops) and accurately quantifies effects as well as number of system states. (ii) Dynamical modelling of cell–cell interactions of plant Arapidopsis thaliana against Pseudomonas syringae DC3000: We analyze for the first time the pathogen perspective and its interaction with the host. We next provide a detailed analysis on how plant hormonal regulation stimulates specific proteins and who and which protein has which type and amount of network control including a detailed heatmap of the A.thaliana response distinguishing between two states of the immune response. (iii) In an immune response network of dendritic cells confronted with Aspergillus fumigatus, JimenaE calculates now accurately the specific values for centralities and protein-specific network control including chemokine and pattern recognition receptors.
The effect of inherently threatening contexts on visuocortical engagement to conditioned threat
(2023)
Fear and anxiety are crucial for adaptive responding in life‐threatening situations. Whereas fear is a phasic response to an acute threat accompanied by selective attention, anxiety is characterized by a sustained feeling of apprehension and hypervigilance during situations of potential threat. In the current literature, fear and anxiety are usually considered mutually exclusive, with partially separated neural underpinnings. However, there is accumulating evidence that challenges this distinction between fear and anxiety, and simultaneous activation of fear and anxiety networks has been reported. Therefore, the current study experimentally tested potential interactions between fear and anxiety. Fifty‐two healthy participants completed a differential fear conditioning paradigm followed by a test phase in which the conditioned stimuli were presented in front of threatening or neutral contextual images. To capture defense system activation, we recorded subjective (threat, US‐expectancy), physiological (skin conductance, heart rate) and visuocortical (steady‐state visual evoked potentials) responses to the conditioned stimuli as a function of contextual threat. Results demonstrated successful fear conditioning in all measures. In addition, threat and US‐expectancy ratings, cardiac deceleration, and visuocortical activity were enhanced for fear cues presented in threatening compared with neutral contexts. These results are in line with an additive or interactive rather than an exclusive model of fear and anxiety, indicating facilitated defensive behavior to imminent danger in situations of potential threat.
Anxiety is characterized by anxious anticipation and heightened vigilance to uncertain threat. However, if threat is not reliably indicated by a specific cue, the context in which threat was previously experienced becomes its best predictor, leading to anxiety. A suitable means to induce anxiety experimentally is context conditioning: In one context (CTX+), an unpredictable aversive stimulus (US) is repeatedly presented, in contrast to a second context (CTX−), in which no US is ever presented. In this EEG study, we investigated attentional mechanisms during acquisition and extinction learning in 38 participants, who underwent a context conditioning protocol. Flickering video stimuli (32 s clips depicting virtual offices representing CTX+/−) were used to evoke steady‐state visual evoked potentials (ssVEPs) as an index of visuocortical engagement with the contexts. Analyses of the electrocortical responses suggest a successful induction of the ssVEP signal by video presentation in flicker mode. Furthermore, we found clear indices of context conditioning and extinction learning on a subjective level, while cortical processing of the CTX+ was unexpectedly reduced during video presentation. The differences between CTX+ and CTX− diminished during extinction learning. Together, these results indicate that the dynamic sensory input of the video presentation leads to disruptions in the ssVEP signal, which is greater for motivationally significant, threatening contexts.
This thematic issue addresses the relationship between local self-governance and the state. Self-governance is understood as the rules that emerge in the local social and spatial context. Local self-governance of individual local groups, actors, communities, and their social and institutional arrangements are considered. From this situated collective entanglement, the interactions and relations with state authorities are analysed in the various contributions embedded in local contexts of different world regions and based on empirical social science research containing mostly interdisciplinary approaches. The nine case studies of this thematic issue reflect a variety of statehoods (weak to restrained), divers “intentionalities” of local self-governance (emancipatory and democratic, socio-economically, and socio-culturally oriented, security-driven or ecological), and their state-locality entanglements range between four forms of relationships: mutually supportive, conflictual, ambivalent, and avoiding.
How do people estimate the income that is needed to be rich? Two correlative survey studies (Study 1 and 2, N = 568) and one registered experimental study (Study 3, N = 500) examined the cognitive mechanisms that are used to derive an answer to this question. We tested whether individuals use their personal income (PI) as a self‐generated anchor to derive an estimate of the income needed to be rich (= income wealth threshold estimation, IWTE). On a bivariate level, we found the expected positive relationship between one's PI and IWTE and, in line with previous findings, we found that people do not consider themselves rich. Furthermore, we predicted that individuals additionally use information about their social status within their social circles to make an IWTE. The findings from study 2 support this notion and show that only self‐reported high‐income individuals show different IWTEs depending on relative social status: Individuals in this group who self‐reported a high status produced higher IWTEs than individuals who self‐reported low status. The registered experimental study could not replicate this pattern robustly, although the results trended non‐significantly in the same direction. Together, the findings revealed that the income of individuals as well as the social environment are used as sources of information to make IWTE judgements, although they are likely not the only important predictors.
When trying to conceal one's knowledge, various ocular changes occur. However, which cognitive mechanisms drive these changes? Do orienting or inhibition—two processes previously associated with autonomic changes—play a role? To answer this question, we used a Concealed Information Test (CIT) in which participants were either motivated to conceal (orienting + inhibition) or reveal (orienting only) their knowledge. While pupil size increased in both motivational conditions, the fixation and blink CIT effects were confined to the conceal condition. These results were mirrored in autonomic changes, with skin conductance increasing in both conditions while heart rate decreased solely under motivation to conceal. Thus, different cognitive mechanisms seem to drive ocular responses. Pupil size appears to be linked to the orienting of attention (akin to skin conductance changes), while fixations and blinks rather seem to reflect arousal inhibition (comparable to heart rate changes). This knowledge strengthens CIT theory and illuminates the relationship between ocular and autonomic activity.
Although most protective behaviors related to the COVID‐19 pandemic come with personal costs, they will produce the largest benefit if everybody cooperates. This study explores two interacting factors that drive cooperation in this tension between private and collective interests. A preregistered experiment (N = 299) examined (a) how the quality of the relation among interacting partners (social proximity), and (b) how focusing on the risk of self‐infection versus onward transmission affected intentions to engage in protective behaviors. The results suggested that risk focus was an important moderator of the relation between social proximity and protection intentions. Specifically, participants were more willing to accept the risk of self‐infection from close others than from strangers, resulting in less caution toward a friend than toward a distant other. However, when onward transmission was the primary concern, participants were more reluctant to effect transmission to close others, resulting in more caution toward friends than strangers. These findings inform the debate about effective nonclinical measures against the pandemic. Practical implications for risk communication are discussed.
Analysis of cerebral glucose metabolism following experimental subarachnoid hemorrhage over 7 days
(2023)
Little is known about changes in brain metabolism following SAH, possibly leading towards secondary brain damage. Despite sustained progress in the last decade, analysis of in vivo acquired data still remains challenging. The present interdisciplinary study uses a semi-automated data analysis tool analyzing imaging data independently from the administrated radiotracer. The uptake of 2-[18F]Fluoro-2-deoxy-glucose ([\(^{18}\)F]FDG) was evaluated in different brain regions in 14 male Sprague–Dawley rats, randomized into two groups: (1) SAH induced by the endovascular filament model and (2) sham operated controls. Serial [\(^{18}\)F]FDG-PET measurements were carried out. Quantitative image analysis was performed by uptake ratio using a self-developed MRI-template based data analysis tool. SAH animals showed significantly higher [\(^{18}\)F]FDG accumulation in gray matter, neocortex and olfactory system as compared to animals of the sham group, while white matter and basal forebrain region showed significant reduced tracer accumulation in SAH animals. All significant metabolic changes were visualized from 3 h, over 24 h (day 1), day 4 and day 7 following SAH/sham operation. This [\(^{18}\)F]FDG-PET study provides important insights into glucose metabolism alterations following SAH—for the first time in different brain regions and up to day 7 during course of disease.
A cyclic alkyl(amino)carbene (CAAC)‐stabilized dicoordinate aminoborylene is synthesized by the twofold reduction of a [(CAAC)BCl\(_{2}\)(TMP)] (TMP=2,6‐tetramethylpiperidyl) precursor. NMR‐spectroscopic, X‐ray crystallographic and computational analyses confirm the cumulenic nature of the central C=B=N moiety. Irradiation of [(CAAC)B(TMP)] (2) resulted in an intramolecular C−C bond activation, leading to a doubly‐fused C\(_{10}\)BN heterocycle, while the reaction with acetonitrile resulted in an aryl migration from the CAAC to the acetonitrile nitrogen atom, concomitant with tautomerization of the latter to a boron‐bound allylamino ligand. One‐electron oxidation of 2 with CuX (X=Cl, Br) afforded the corresponding amino(halo)boryl radicals, which were characterized by EPR spectroscopy and DFT calculations. Placing 2 under an atmosphere of CO afforded the tricoordinate (CAAC,CO)‐stabilized aminoborylene. Finally, the twofold oxidation of 2 with chalcogens led, in the case of N\(_{2}\)O and sulfur, to the splitting of the B−C\(_{CAAC}\) bond and formation of the 2,4‐diamino‐1,3,2,4‐dichalcogenadiboretanes and CAAC‐chalcogen adducts, whereas with selenium a monomeric boraselenone was isolated, which showed some degree of B−Se multiple bonding.
Carbene‐stabilized diborynes of the form LBBL (L=N‐heterocyclic carbene (NHC) or cyclic alkyl(amino)carbene (CAAC)) induce rapid, high yielding, intermolecular ortho‐C−H borylation at N‐heterocycles at room temperature. A simple pyridyldiborene is formed when an NHC‐stabilized diboryne is combined with pyridine, while a CAAC‐stabilized diboryne leads to activation of two pyridine molecules to give a tricyclic alkylideneborane, which can be forced to undergo a further H‐shift resulting in a zwitterionic, doubly benzo‐fused 1,3,2,5‐diazadiborinine by heating. Use of the extended N‐heteroaromatic quinoline leads to a borylmethyleneborane under mild conditions via an unprecedented boron‐carbon exchange process.
Spontaneous brain activity builds the foundation for human cognitive processing during external demands. Neuroimaging studies based on functional magnetic resonance imaging (fMRI) identified specific characteristics of spontaneous (intrinsic) brain dynamics to be associated with individual differences in general cognitive ability, i.e., intelligence. However, fMRI research is inherently limited by low temporal resolution, thus, preventing conclusions about neural fluctuations within the range of milliseconds. Here, we used resting-state electroencephalographical (EEG) recordings from 144 healthy adults to test whether individual differences in intelligence (Raven’s Advanced Progressive Matrices scores) can be predicted from the complexity of temporally highly resolved intrinsic brain signals. We compared different operationalizations of brain signal complexity (multiscale entropy, Shannon entropy, Fuzzy entropy, and specific characteristics of microstates) regarding their relation to intelligence. The results indicate that associations between brain signal complexity measures and intelligence are of small effect sizes (r ∼ 0.20) and vary across different spatial and temporal scales. Specifically, higher intelligence scores were associated with lower complexity in local aspects of neural processing, and less activity in task-negative brain regions belonging to the default-mode network. Finally, we combined multiple measures of brain signal complexity to show that individual intelligence scores can be significantly predicted with a multimodal model within the sample (10-fold cross-validation) as well as in an independent sample (external replication, N = 57). In sum, our results highlight the temporal and spatial dependency of associations between intelligence and intrinsic brain dynamics, proposing multimodal approaches as promising means for future neuroscientific research on complex human traits.
Proton‐coupled electron‐transfer (PCET) processes play a key role in biocatalytic energy conversion and storage, for example, photosynthesis or nitrogen fixation. Here, we report a series of bipyridine‐containing di‐ to tetranuclear Ru(bda) macrocycles 2 C–4 C (bda: 2,2′‐bipyridine‐6,6′‐dicarboxylate) to promote O−O bond formation. In photocatalytic water oxidation under neutral conditions, all complexes 2 C–4 C prevail in a folded conformation that support the water nucleophilic attack (WNA) pathway with remarkable turnover frequencies of up to 15.5 s\(^{−1}\) per Ru unit respectively. Single‐crystal X‐ray analysis revealed an increased tendency for intramolecular π‐π stacking and preorganization of the proximal bases close to the active centers for the larger macrocycles. H/D kinetic isotope effect studies and electrochemical data demonstrate the key role of the proximal bipyridines as proton acceptors in lowering the activation barrier for the crucial nucleophilic attack of H\(_{2}\)O in the WNA mechanism.
Isolated 2‐phenylallyl radicals (2‐PA), generated by pyrolysis from a nitrite precursor, have been investigated by IR/UV ion dip spectroscopy using free electron laser radiation. 2‐PA is a resonance‐stabilized radical that is considered to be involved in the formation of polycyclic aromatic hydrocarbons (PAH) in combustion, but also in interstellar space. The radical is identified based on its gas‐phase IR spectrum. Furthermore, a number of bimolecular reaction products are identified, showing that the self‐reaction as well as reactions with unimolecular decomposition products of 2‐PA form several PAH efficiently. Possible mechanisms are discussed and the chemistry of 2‐PA is compared with the one of the related 2‐methylallyl and phenylpropargyl radicals.
The great progress in organic photovoltaics (OPV) over the past few years has been largely achieved by the development of non‐fullerene acceptors (NFAs), with power conversion efficiencies now approaching 20%. To further improve device performance, loss mechanisms must be identified and minimized. Triplet states are known to adversely affect device performance, since they can form energetically trapped excitons on low‐lying states that are responsible for non‐radiative losses or even device degradation. Halogenation of OPV materials has long been employed to tailor energy levels and to enhance open circuit voltage. Yet, the influence on recombination to triplet excitons has been largely unexplored. Using the complementary spin‐sensitive methods of photoluminescence detected magnetic resonance and transient electron paramagnetic resonance corroborated by transient absorption and quantum‐chemical calculations, exciton pathways in OPV blends are unravelled employing the polymer donors PBDB‐T, PM6, and PM7 together with NFAs Y6 and Y7. All blends reveal triplet excitons on the NFA populated via non‐geminate hole back transfer and, in blends with halogenated donors, also by spin‐orbit coupling driven intersystem crossing. Identifying these triplet formation pathways in all tested solar cell absorber films highlights the untapped potential for improved charge generation to further increase plateauing OPV efficiencies.
Exploring the Relationship Between Social Movement Organizations and the State in Latin America
(2023)
Under conditions of weak statehood, societal actors are supposed to assume functions usually attributed to the state. Social self-organization is expected to emerge when the state leaves important social problems unattended. Should social self-organization, therefore, be regarded as a reaction to state weakness and as compensation for state failure in the provision of basic services? Does society organize itself on its own in areas where the state is absent or ineffective? By the example of two Latin American social movements, this article aims to show that social self-organization—at least on a larger scale—is not independent of the state, but rather a result of a dynamic interaction with the state. The two examples this article explores are the middle-class Venezuelan neighborhood movement and the Argentine piquetero movement of unemployed workers. Both movements emerged as reactions to the state’s failure and retreat from essential social functions and both developed into extensive and influential social actors. For that reason, they can be regarded as crucial cases for observing the patterns and conditions of social self-organization and autonomous collective action within the specific Latin American context. Despite their different backgrounds and social bases, the two cases reveal remarkable similarities. They show that the emergence and development of self-organized social groups cannot be conceived simply as a reaction to state weakness, but rather should be viewed as a dynamic interaction with the state.
Among the parent borirane, benzoborirene and ortho‐dicarbadodecaborane‐fused borirane, the latter possesses the highest ring strain and the highest Lewis acidity according to our density functional theory (DFT) studies. The synthesis of this class of compounds is thus considerably challenging. The existing examples require either a strong π‐donating group or an extra ligand for B‐coordination, which nevertheless suppresses or completely turns off the Lewis acidity. The title compound, which possesses both features, not only allows the 1,2‐insertion of P=O, C=O or C≡N to proceed under milder conditions, but also enables the heretofore unknown dearomative 1,4‐insertion of Ar−(C=O)− into a B−C bond. The fusion of strained molecular systems to an o‐carborane cage shows great promise for boosting both the ring strain and acidity.
Evidence synthesis findings depend on the assumption that the included studies follow good clinical practice and results are not fabricated or false. Studies which are problematic due to scientific misconduct, poor research practice, or honest error may distort evidence synthesis findings. Authors of evidence synthesis need transparent mechanisms to identify and manage problematic studies to avoid misleading findings. As evidence synthesis authors of the Cochrane COVID-19 review on ivermectin, we identified many problematic studies in terms of research integrity and regulatory compliance. Through iterative discussion, we developed a research integrity assessment (RIA) tool for randomized controlled trials for the update of this Cochrane review. In this paper, we explain the rationale and application of the RIA tool in this case study. RIA assesses six study criteria: study retraction, prospective trial registration, adequate ethics approval, author group, plausibility of methods (e.g., randomization), and plausibility of study results. RIA was used in the Cochrane review as part of the eligibility check during screening of potentially eligible studies. Problematic studies were excluded and studies with open questions were held in awaiting classification until clarified. RIA decisions were made independently by two authors and reported transparently. Using the RIA tool resulted in the exclusion of >40% of studies in the first update of the review. RIA is a complementary tool prior to assessing “Risk of Bias” aiming to establish the integrity and authenticity of studies. RIA provides a platform for urgent development of a standard approach to identifying and managing problematic studies.
Background
Ischemic stroke immediately evokes a strong neuro-inflammatory response within the vascular compartment, which contributes to primary infarct development under vessel occlusion as well as further infarct growth despite recanalization, referred to as ischemia/reperfusion injury. Later, in the subacute phase of stroke (beyond day 1 after recanalization), further inflammatory processes within the brain parenchyma follow. Whether this second wave of parenchymal inflammation contributes to an additional/secondary increase in infarct volumes and bears the potential to be pharmacologically targeted remains elusive. We addressed the role of the NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome in the subacute phase of ischemic stroke.
Methods
Focal cerebral ischemia was induced in C57Bl/6 mice by a 30-min transient middle cerebral artery occlusion (tMCAO). Animals were treated with the NLRP3 inhibitor MCC950 therapeutically 24 h after or prophylactically before tMCAO. Stroke outcome, including infarct size and functional deficits as well as the local inflammatory response, was assessed on day 7 after tMCAO.
Results
Infarct sizes on day 7 after tMCAO decreased about 35% after delayed and about 60% after prophylactic NLRP3 inhibition compared to vehicle. Functionally, pharmacological inhibition of NLRP3 mitigated the local inflammatory response in the ischemic brain as indicated by reduction of infiltrating immune cells and reactive astrogliosis.
Conclusions
Our results demonstrate that the NLRP3 inflammasome continues to drive neuroinflammation within the subacute stroke phase. NLRP3 inflammasome inhibition leads to a better long-term outcome—even when administered with a delay of 1 day after stroke induction, indicating ongoing inflammation-driven infarct progression. These findings may pave the way for eagerly awaited delayed treatment options in ischemic stroke.
Objectives
Although the vast majority of COVID-19 cases are treated in primary care, patients' experiences during home isolation have been little studied. This study aimed to explore the experiences of patients with acute COVID-19 and to identify challenges after the initial adaptation of the German health system to the pandemic (after first infection wave from February to June 2020).
Methods
A mixed-method convergent design was used to gain a holistic insight into patients experience. The study consisted of a cross-sectional survey, open survey answers and semi-structured telephone interviews. Descriptive analysis was performed on quantitative survey answers. Between group differences were calculated to explore changes after the first infection wave. Qualitative thematic analysis was conducted on open survey answers and interviews. The results were then compared within a triangulation protocol.
Results
A total of 1100 participants from all German states were recruited by 145 general practitioners from August 2020 to April 2021, 42 additionally took part in qualitative interviews. Disease onset varied from February 2020 to April 2021. After the first infection wave, more participants were tested positive during the acute disease (88.8%; 95.2%; P < 0.001). Waiting times for tests (mean 4.5 days, SD 4.1; 2.7days, SD 2.6, P < 0.001) and test results (mean 2.4 days, SD 1.9; 1.8 days, SD 1.3, P < 0.001) decreased. Qualitative results indicated that the availability of repeated testing and antigen tests reduced insecurities, transmission and related guilt. Although personal consultations at general practices increased (6.8%; 15.5%, P < 0.001), telephone consultation remained the main mode of consultation (78.5%) and video remained insignificant (1.9%). The course of disease, the living situation and social surroundings during isolation, access to health care, personal resilience, spirituality and feelings of guilt and worries emerged as themes influencing the illness experience. Challenges were contact management and adequate provision of care during home isolation. A constant contact person within the health system helped against feelings of care deprivation, uncertainty and fear.
Conclusions
Our study highlights that home isolation of individuals with COVID-19 requires a holistic approach that considers all aspects of patient care and effective coordination between different care providers.
Non-aureus staphylococci (NAS) are ubiquitous bacteria in livestock-associated environments where they may act as reservoirs of antimicrobial resistance (AMR) genes for pathogens such as Staphylococcus aureus. Here, we tested whether housing conditions in pig farms could influence the overall AMR-NAS burden. Two hundred and forty porcine commensal and environmental NAS isolates from three different farm types (conventional, alternative, and organic) were tested for phenotypic antimicrobial susceptibility and subjected to whole genome sequencing. Genomic data were analysed regarding species identity and AMR gene carriage. Seventeen different NAS species were identified across all farm types. In contrast to conventional farms, no AMR genes were detectable towards methicillin, aminoglycosides, and phenicols in organic farms. Additionally, AMR genes to macrolides and tetracycline were rare among NAS in organic farms, while such genes were common in conventional husbandries. No differences in AMR detection existed between farm types regarding fosfomycin, lincosamides, fusidic acid, and heavy metal resistance gene presence. The combined data show that husbandry conditions influence the occurrence of resistant and multidrug-resistant bacteria in livestock, suggesting that changing husbandry practices may be an appropriate means of limiting the spread of AMR bacteria on farms.
Enterococcus faecalis and Enterococcus faecium are major nosocomial pathogens. Despite their relevance to public health and their role in the development of bacterial antibiotic resistance, relatively little is known about gene regulation in these species. RNA–protein complexes serve crucial functions in all cellular processes associated with gene expression, including post-transcriptional control mediated by small regulatory RNAs (sRNAs). Here, we present a new resource for the study of enterococcal RNA biology, employing the Grad-seq technique to comprehensively predict complexes formed by RNA and proteins in E. faecalis V583 and E. faecium AUS0004. Analysis of the generated global RNA and protein sedimentation profiles led to the identification of RNA–protein complexes and putative novel sRNAs. Validating our data sets, we observe well-established cellular RNA–protein complexes such as the 6S RNA–RNA polymerase complex, suggesting that 6S RNA-mediated global control of transcription is conserved in enterococci. Focusing on the largely uncharacterized RNA-binding protein KhpB, we use the RIP-seq technique to predict that KhpB interacts with sRNAs, tRNAs, and untranslated regions of mRNAs, and might be involved in the processing of specific tRNAs. Collectively, these datasets provide departure points for in-depth studies of the cellular interactome of enterococci that should facilitate functional discovery in these and related Gram-positive species. Our data are available to the community through a user-friendly Grad-seq browser that allows interactive searches of the sedimentation profiles (https://resources.helmholtz-hiri.de/gradseqef/).
Azobenzene derivatives with activity against drug‐resistant Candida albicans and Candida auris
(2023)
Increasing resistance against antimycotic drugs challenges anti‐infective therapies today and contributes to the mortality of infections by drug‐resistant Candida species and strains. Therefore, novel antifungal agents are needed. A promising approach in developing new drugs is using naturally occurring molecules as lead structures. In this work, 4,4'‐dihydroxyazobenzene, a compound structurally related to antifungal stilbene derivatives and present in Agaricus xanthodermus (yellow stainer), served as a starting point for the synthesis of five azobenzene derivatives. These compounds prevented the growth of both fluconazole‐susceptible and fluconazole‐resistant Candida albicans and Candida auris strains. Further in vivo studies are required to confirm the potential therapeutic value of these compounds.
[\(^{223}\)Ra]RaCl\(_2\) and [\(^{224}\)Ra]RaCl\(_2\) are bone seekers, emitting high LET, and short range (< 100 μm) alpha-particles. Both radionuclides show similar decay properties; the total alpha energies are comparable (\(^{223}\)Ra: ≈28 MeV, \(^{224}\)Ra: ≈26 MeV). [\(^{224}\)Ra]RaCl\(_2\) has been used from the mid-1940s until 1990 for treating different bone and joint diseases with activities of up to approximately 50 MBq [\(^{224}\)Ra]RaCl\(_2\). In 2013 [\(^{223}\)Ra]RaCl\(_2\) obtained marketing authorization by the FDA and by the European Union for the treatment of metastatic prostate cancer with an activity to administer of 0.055 MBq per kg body weight for six cycles. For intravenous injections in humans a model calculation using the biokinetic model of ICRP67 shows a ratio of organ absorbed dose coefficients (\(^{224}\)Ra:\(^{223}\)Ra) between 0.37 (liver) and 0.97 except for the kidneys (2.27) and blood (1.57). For the red marrow as primary organ-at-risk, the ratio is 0.57. The differences are mainly caused be the differing half-lives of the decay products of both radium isotopes. Both radionuclides show comparable DNA damage patterns in peripheral blood mononuclear cells after internal ex-vivo irradiation. Data on the long-term radiation-associated side effects are only available for treatment with [\(^{224}\)Ra]RaCl\(_2\). Two epidemiological studies followed two patient groups treated with [\(^{224}\)Ra]RaCl\(_2\) for more than 25 years. One of them was the “Spiess study”, a cohort of 899 juvenile patients who received several injections of [\(^{224}\)Ra]RaCl\(_2\) with a mean specific activity of 0.66 MBq/kg. Another patient group of ankylosing spondylitis patients was treated with 10 repeated intravenous injections of [\(^{224}\)Ra]RaCl\(_2\), 1 MBq each, 1 week apart. In total 1,471 of these patients were followed-up in the “Wick study”. In both studies, an increased cancer mortality by leukemia and solid cancers was observed. Similar considerations on long-term effects likely apply to [\(^{223}\)Ra]RaCl\(_2\) as well since the biokinetics are similar and the absorbed doses in the same range. However, this increased risk will most likely not be observed due to the much shorter life expectancy of prostate cancer patients treated with [\(^{223}\)Ra]RaCl\(_2\).
“In Other News”: China’s International Media Strategy on Xinjiang — CGTN and New China TV on YouTube
(2023)
In the Western world China stands accused of severe human rights violations regarding its treatment of the Uyghurs and other predominantly Muslim minorities in its northwestern Xinjiang Uyghur Autonomous Region. This is the first article to systematically analyze the response of China’s international state media to these allegations. By studying the YouTube channels of two leading Chinese state media, China Global Television Network (CGTN) and New China TV (operated by Xinhua News Agency), it presents an indepth understanding of how China’s foreign-facing propaganda works in a crucial case. The quantitative content analysis highlights how China reacted to increasing international (mostly United States) pressure regarding its Xinjiang policies by producing higher volumes of videos and putting out new counternarratives. The qualitative analysis that follows provides in-depth treatment of the most important discourses that Chinese media engage in to salvage the nation’s international image, namely those on development, culture, nature, and terrorism. It finds several ways of countering criticism, ranging from presenting a positive image of China, in line with traditional propaganda guidelines and President Xi Jinping’s assignment to state media to “tell the China story well,” to more innovative approaches. Thus the development narrative becomes more personalized, the discourse on culture supports the “heritagization process” to incorporate minority cultures into a harmonized “Chinese civilization,” representations of nature firmly tie Xinjiang into the discourse of “beautiful China,” the “terror narrative” strategically employs shocking footage in an attempt to gain international “discourse power,” etc. The article provides an up-to-date picture of China’s state media strategy on a highly contentious international issue.
Perylene bisimides (PBIs) are among the best fluorophores but have to be enwrapped for optoelectronic applications by large and heavy substituents to prevent their ππ‐stacking, which is known to accelerate non‐radiative decay processes in the solid state. Here, light‐weight di‐tert‐butylsilyl groups are introduced to bridge 1,12‐dihydroxy and 1,6,7,12‐tetrahydroxy PBIs to afford sublimable dyes for vacuum‐processed optoelectronic devices. For both new compounds, this substitution provides a twisted and shielded perylene π‐core whose, via OSiObridges, rigid structure affords well‐resolved absorption and emission spectra with strong fluorescence in solution, as well as in the solid state. The usefulness of these dyes for vacuum‐processed optoelectronic devices is demonstrated in organic light‐emitting diodes (OLEDs) that show monomer‐like emission spectra and high maximum external quantum efficiency (EQEmax) values of up to 3.1% for the doubly silicon‐bridged PBI.
Inflammation and oxidative stress represent physiological response mechanisms to different types of stimuli and injury during critical illness. Its proper regulation is fundamental to cellular and organismal survival and are paramount to outcomes and recovery from critical illness. A proper maintenance of the delicate balance between inflammation, oxidative stress, and immune response is crucial for resolution from critical illness with important implications for patient outcome. The extent of inflammation and oxidative stress under normal conditions is limited by the antioxidant defense system of the human body, whereas the antioxidant capacity is commonly significantly compromised, and serum levels of micronutrients and vitamins significantly depleted in patients who are critically ill. Hence, the provision of antioxidants and anti-inflammatory nutrients may help to reduce the extent of oxidative stress and therefore improve clinical outcomes in patients who are critically ill. As existing evidence of the beneficial effects of antioxidant supplementation in patients who are critically ill is still unclear, actual findings about the most promising anti-inflammatory and antioxidative candidates selenium, vitamin C, zinc, and vitamin D will be discussed in this narrative review. The existing evidence provided so far demonstrates that several factors need to be considered to determine the efficacy of an antioxidant supplementation strategy in patients who are critically ill and indicates the need for adequately designed multicenter prospective randomized control trials to evaluate the clinical significance of different types and doses of micronutrients and vitamins in selected groups of patients with different types of critical illness.
Small bacterial regulatory RNAs (sRNAs) have been implicated in the regulation of numerous metabolic pathways. In most of these studies, sRNA-dependent regulation of mRNAs or proteins of enzymes in metabolic pathways has been predicted to affect the metabolism of these bacteria. However, only in a very few cases has the role in metabolism been demonstrated. Here, we performed a combined transcriptome and metabolome analysis to define the regulon of the sibling sRNAs NgncR_162 and NgncR_163 (NgncR_162/163) and their impact on the metabolism of Neisseria gonorrhoeae. These sRNAs have been reported to control genes of the citric acid and methylcitric acid cycles by posttranscriptional negative regulation. By transcriptome analysis, we now expand the NgncR_162/163 regulon by several new members and provide evidence that the sibling sRNAs act as both negative and positive regulators of target gene expression. Newly identified NgncR_162/163 targets are mostly involved in transport processes, especially in the uptake of glycine, phenylalanine, and branched-chain amino acids. NgncR_162/163 also play key roles in the control of serine-glycine metabolism and, hence, probably affect biosyntheses of nucleotides, vitamins, and other amino acids via the supply of one-carbon (C\(_1\)) units. Indeed, these roles were confirmed by metabolomics and metabolic flux analysis, which revealed a bipartite metabolic network with glucose degradation for the supply of anabolic pathways and the usage of amino acids via the citric acid cycle for energy metabolism. Thus, by combined deep RNA sequencing (RNA-seq) and metabolomics, we significantly extended the regulon of NgncR_162/163 and demonstrated the role of NgncR_162/163 in the regulation of central metabolic pathways of the gonococcus.
Wind energy is a key option in global dialogues about climate change mitigation. Here, we combined observations from surface wind stations, reanalysis datasets, and state‐of‐the‐art regional climate models from the Coordinated Regional Climate Downscaling Experiment (CORDEX Africa) to study the current and future wind energy potential in Zambia. We found that winds are dominated by southeasterlies and are rarely strong with an average speed of 2.8 m·s\(^{−1}\). When we converted the observed surface wind speed to a turbine hub height of 100 m, we found a ~38% increase in mean wind speed for the period 1981–2000. Further, both simulated and observed wind speed data show statistically significant increments across much of the country. The only areas that divert from this upward trend of wind speeds are the low land terrains of the Eastern Province bordering Malawi. Examining projections of wind power density (WPD), we found that although wind speed is increasing, it is still generally too weak to support large‐scale wind power generation. We found a meagre projected annual average WPD of 46.6 W·m\(^{−2}\). The highest WPDs of ~80 W·m\(^{−2}\) are projected in the northern and central parts of the country while the lowest are to be expected along the Luangwa valley in agreement with wind speed simulations. On average, Zambia is expected to experience minor WPD increments of 0.004 W·m\(^{−2}\) per year from 2031 to 2050. We conclude that small‐scale wind turbines that accommodate cut‐in wind speeds of 3.8 m·s\(^{−1}\) are the most suitable for power generation in Zambia. Further, given the limitations of small wind turbines, they are best suited for rural and suburban areas of the country where obstructions are few, thus making them ideal for complementing the government of the Republic of Zambia's rural electrification efforts.
Polymeric Janus Fibers
(2023)
Janus fibers are a class of composite materials comprising mechanical and chemical to biological functionality. Combining different materials and functionalities in one micro- or even nanoscale fiber enables otherwise unreachable synergistic physicochemical effects with unprecedented opportunities for technical or biomedical applications. Here, recent developments of processing technologies and applications of polymeric Janus fibers will be reviewed. Various examples in the fields of textiles, catalysis, sensors as well as medical applications, like drug delivery systems, tissue engineering and antimicrobial materials, are presented to illuminate the outstanding potential of such high-end functional materials for novel applications in the upcoming future.
The fast and accurate yield estimates with the increasing availability and variety of global satellite products and the rapid development of new algorithms remain a goal for precision agriculture and food security. However, the consistency and reliability of suitable methodologies that provide accurate crop yield outcomes still need to be explored. The study investigates the coupling of crop modeling and machine learning (ML) to improve the yield prediction of winter wheat (WW) and oil seed rape (OSR) and provides examples for the Free State of Bavaria (70,550 km2), Germany, in 2019. The main objectives are to find whether a coupling approach [Light Use Efficiency (LUE) + Random Forest (RF)] would result in better and more accurate yield predictions compared to results provided with other models not using the LUE. Four different RF models [RF1 (input: Normalized Difference Vegetation Index (NDVI)), RF2 (input: climate variables), RF3 (input: NDVI + climate variables), RF4 (input: LUE generated biomass + climate variables)], and one semi-empiric LUE model were designed with different input requirements to find the best predictors of crop monitoring. The results indicate that the individual use of the NDVI (in RF1) and the climate variables (in RF2) could not be the most accurate, reliable, and precise solution for crop monitoring; however, their combined use (in RF3) resulted in higher accuracies. Notably, the study suggested the coupling of the LUE model variables to the RF4 model can reduce the relative root mean square error (RRMSE) from −8% (WW) and −1.6% (OSR) and increase the R
2 by 14.3% (for both WW and OSR), compared to results just relying on LUE. Moreover, the research compares models yield outputs by inputting three different spatial inputs: Sentinel-2(S)-MOD13Q1 (10 m), Landsat (L)-MOD13Q1 (30 m), and MOD13Q1 (MODIS) (250 m). The S-MOD13Q1 data has relatively improved the performance of models with higher mean R
2 [0.80 (WW), 0.69 (OSR)], and lower RRMSE (%) (9.18, 10.21) compared to L-MOD13Q1 (30 m) and MOD13Q1 (250 m). Satellite-based crop biomass, solar radiation, and temperature are found to be the most influential variables in the yield prediction of both crops.
Atmospheric circulation is a key driver of climate variability, and the representation of atmospheric circulation modes in regional climate models (RCMs) can enhance the credibility of regional climate projections. This study examines the representation of large‐scale atmospheric circulation modes in Coupled Model Inter‐comparison Project phase 5 RCMs once driven by ERA‐Interim, and by two general circulation models (GCMs). The study region is Western Europe and the circulation modes are classified using the Promax rotated T‐mode principal component analysis. The results indicate that the RCMs can replicate the classified atmospheric modes as obtained from ERA5 reanalysis, though with biases dependent on the data providing the lateral boundary condition and the choice of RCM. When the boundary condition is provided by ERA‐Interim that is more consistent with observations, the simulated map types and the associating time series match well with their counterparts from ERA5. Further, on average, the multi‐model ensemble mean of the analysed RCMs, driven by ERA‐Interim, indicated a slight improvement in the representation of the modes obtained from ERA5. Conversely, when the RCMs are driven by the GCMs that are models without assimilation of observational data, the representation of the atmospheric modes, as obtained from ERA5, is relatively less accurate compared to when the RCMs are driven by ERA‐Interim. This suggests that the biases stem from the GCMs. On average, the representation of the modes was not improved in the multi‐model ensemble mean of the five analysed RCMs driven by either of the GCMs. However, when the best‐performed RCMs were selected on average the ensemble mean indicated a slight improvement. Moreover, the presence of the North Atlantic Oscillation (NAO) in the simulated modes depends also on the lateral boundary conditions. The relationship between the modes and the NAO was replicated only when the RCMs were driven by reanalysis. The results indicate that the forcing model is the main factor in reproducing the atmospheric circulation.
A series of novel imide‐functionalized C\(_{64}\) nanographenes is investigated as acceptor components in organic solar cells (OSCs) in combination with donor polymer PM6. These electron‐poor molecules either prevail as a monomer or self‐assemble into dimers in the OSC active layer depending on the chosen imide substituents. This allows for the controlled stacking of electron‐poor and electron‐rich π–scaffolds to establish a novel class of non‐fullerene acceptor materials to tailor the bulk‐heterojunction morphology of the OSCs. The best performance is observed for derivatives that are able to self‐assemble into dimers, reaching power conversion efficiencies of up to 7.1%.
Aim
Global warming is assumed to restructure mountain insect communities in space and time. Theory and observations along climate gradients predict that insect abundance and richness, especially of small‐bodied species, will increase with increasing temperature. However, the specific responses of single species to rising temperatures, such as spatial range shifts, also alter communities, calling for intensive monitoring of real‐world communities over time.
Location
German Alps and pre‐alpine forests in south‐east Germany.
Methods
We empirically examined the temporal and spatial change in wild bee communities and its drivers along two largely well‐protected elevational gradients (alpine grassland vs. pre‐alpine forest), each sampled twice within the last decade.
Results
We detected clear abundance‐based upward shifts in bee communities, particularly in cold‐adapted bumble bee species, demonstrating the speed with which mobile organisms can respond to climatic changes. Mean annual temperature was identified as the main driver of species richness in both regions. Accordingly, and in large overlap with expectations under climate warming, we detected an increase in bee richness and abundance, and an increase in small‐bodied species in low‐ and mid‐elevations along the grassland gradient. Community responses in the pre‐alpine forest gradient were only partly consistent with community responses in alpine grasslands.
Main Conclusion
In well‐protected temperate mountain regions, small‐bodied bees may initially profit from warming temperatures, by getting more abundant and diverse. Less severe warming, and differences in habitat openness along the forested gradient, however, might moderate species responses. Our study further highlights the utility of standardized abundance data for revealing rapid changes in bee communities over only one decade.
Honeybees (Apis mellifera) need their fine sense of taste to evaluate nectar and pollen sources. Gustatory receptors (Grs) translate taste signals into electrical responses. In vivo experiments have demonstrated collective responses of the whole Gr-set. We here disentangle the contributions of all three honeybee sugar receptors (AmGr1-3), combining CRISPR/Cas9 mediated genetic knock-out, electrophysiology and behaviour. We show an expanded sugar spectrum of the AmGr1 receptor. Mutants lacking AmGr1 have a reduced response to sucrose and glucose but not to fructose. AmGr2 solely acts as co-receptor of AmGr1 but not of AmGr3, as we show by electrophysiology and using bimolecular fluorescence complementation. Our results show for the first time that AmGr2 is indeed a functional receptor on its own. Intriguingly, AmGr2 mutants still display a wildtype-like sugar taste. AmGr3 is a specific fructose receptor and is not modulated by a co-receptor. Eliminating AmGr3 while preserving AmGr1 and AmGr2 abolishes the perception of fructose but not of sucrose. Our comprehensive study on the functions of AmGr1, AmGr2 and AmGr3 in honeybees is the first to combine investigations on sugar perception at the receptor level and simultaneously in vivo. We show that honeybees rely on two gustatory receptors to sense all relevant sugars.
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic approach, there are limited studies focused on site-specific targeting of GPVI. Using computational modeling and bioinformatics, we analyzed collagen- and CRP-binding surfaces of GPVI monomers and dimers, and compared the interacting surfaces with other mammalian GPVI isoforms. We could predict a minimal collagen-binding epitope of GPVI dimer and designed an EA-20 antibody that recognizes a linear epitope of this surface. Using platelets and whole blood samples donated from wild-type and humanized GPVI transgenic mice and also humans, our experimental results show that the EA-20 antibody inhibits platelet adhesion and aggregation in response to collagen and CRP, but not to fibrin. The EA-20 antibody also prevents thrombus formation in whole blood, on the collagen-coated surface, in arterial flow conditions. We also show that EA-20 does not influence GPVI clustering or receptor shedding. Therefore, we propose that blockade of this minimal collagen-binding epitope of GPVI with the EA-20 antibody could represent a new anti-thrombotic approach by inhibiting specific interactions between GPVI and the collagen matrix.
Physicians play an important role in adapting to and mitigating the adverse health effects of the unfolding climate and ecological crises. To fully harness this potential, future physicians need to acquire knowledge, values, skills, and leadership attributes to care for patients presenting with environmental change-related conditions and to initiate and propel transformative change in healthcare and other sectors of society including, but not limited to, the decarbonization of healthcare systems, the transition to renewable energies and the transformation of transport and food systems. Despite the potential of Planetary Health Education (PHE) to support medical students in becoming agents of change, best-practice examples of mainstreaming PHE in medical curricula remain scarce both in Germany and internationally. The process of revising and updating the Medical Licensing Regulations and the National Competency-based Catalog of Learning Objectives for Medical Education in Germany provided a window of opportunity to address this implementation challenge. In this article, we describe the development and content of national Planetary Health learning objectives for Germany. We anticipate that the learning objectives will stimulate the development and implementation of innovative Planetary Health teaching, learning and exam formats in medical schools and inform similar initiatives in other health professions. The availability of Planetary Health learning objectives in other countries will provide opportunities for cross-country and interdisciplinary exchange of experiences and validation of content, thus supporting the consolidation of Planetary Health learning objectives and the improvement of PHE for all health professionals globally.
Characterization of binding properties of ephedrine derivatives to human alpha-1-acid glycoprotein
(2023)
Most drugs, especially those with acidic or neutral moieties, are bound to the plasma protein albumin, whereas basic drugs are preferentially bound to human alpha-1-acid glycoprotein (AGP). The protein binding of the long-established drugs ephedrine and pseudoephedrine, which are used in the treatment of hypotension and colds, has so far only been studied with albumin. Since in a previous study a stereoselective binding of ephedrine and pseudoephedrine to serum but not to albumin was observed, the aim of this study was to check whether the enantioselective binding behavior of ephedrine and pseudoephedrine, in addition to the derivatives methylephedrine and norephedrine, is due to AGP and to investigate the influence of their different substituents and steric arrangement. Discontinuous ultrafiltration was used for the determination of protein binding. Characterization of ligand-protein interactions of the drugs was obtained by saturation transfer difference nuclear magnetic resonance spectroscopy. Docking experiments were performed to analyze possible ligand-protein interactions. The more basic the ephedrine derivative is, the higher is the affinity to AGP. There was no significant difference in the binding properties between the individual enantiomers and the diastereomers of ephedrine and pseudoephedrine.
Site-specific introduction of biorthogonal handles into RNAs is in high demand for decorating RNAs with fluorophores, affinity labels or other modifications. Aldehydes represent attractive functional groups for post-synthetic bioconjugation reactions. Here, we report a ribozyme-based method for the synthesis of aldehyde-functionalized RNA by directly converting a purine nucleobase. Using the methyltransferase ribozyme MTR1 as an alkyltransferase, the reaction is initiated by site-specific N1 benzylation of purine, followed by nucleophilic ring opening and spontaneous hydrolysis under mild conditions to yield a 5-amino-4-formylimidazole residue in good yields. The modified nucleotide is accessible to aldehyde-reactive probes, as demonstrated by the conjugation of biotin or fluorescent dyes to short synthetic RNAs and tRNA transcripts. Upon fluorogenic condensation with a 2,3,3-trimethylindole, a novel hemicyanine chromophore was generated directly on the RNA. This work expands the MTR1 ribozyme’s area of application from a methyltransferase to a tool for site-specific late-stage functionalization of RNA.
Although bariatric surgery is known to change the metabolome, it is unclear if this is specific for the intervention or a consequence of the induced bodyweight loss. As the weight loss after Roux-en-Y Gastric Bypass (RYGB) can hardly be mimicked with an evenly effective diet in humans, translational research efforts might be helpful. A group of 188 plasma metabolites of 46 patients from the randomized controlled Würzburg Adipositas Study (WAS) and from RYGB-treated rats (n = 6) as well as body-weight-matched controls (n = 7) were measured using liquid chromatography tandem mass spectrometry. WAS participants were randomized into intensive lifestyle modification (LS, n = 24) or RYGB (OP, n = 22). In patients in the WAS cohort, only bariatric surgery achieved a sustained weight loss (BMI −34.3% (OP) vs. −1.2% (LS), p ≤ 0.01). An explicit shift in the metabolomic profile was found in 57 metabolites in the human cohort and in 62 metabolites in the rodent model. Significantly higher levels of sphingolipids and lecithins were detected in both surgical groups but not in the conservatively treated human and animal groups. RYGB leads to a characteristic metabolomic profile, which differs distinctly from that following non-surgical intervention. Analysis of the human and rat data revealed that RYGB induces specific changes in the metabolome independent of weight loss.
Single-molecule localization microscopy (SMLM) greatly advances structural studies of diverse biological tissues. For example, presynaptic active zone (AZ) nanotopology is resolved in increasing detail. Immunofluorescence imaging of AZ proteins usually relies on epitope preservation using aldehyde-based immunocompetent fixation. Cryofixation techniques, such as high-pressure freezing (HPF) and freeze substitution (FS), are widely used for ultrastructural studies of presynaptic architecture in electron microscopy (EM). HPF/FS demonstrated nearer-to-native preservation of AZ ultrastructure, e.g., by facilitating single filamentous structures. Here, we present a protocol combining the advantages of HPF/FS and direct stochastic optical reconstruction microscopy (dSTORM) to quantify nanotopology of the AZ scaffold protein Bruchpilot (Brp) at neuromuscular junctions (NMJs) of Drosophila melanogaster. Using this standardized model, we tested for preservation of Brp clusters in different FS protocols compared to classical aldehyde fixation. In HPF/FS samples, presynaptic boutons were structurally well preserved with ~22% smaller Brp clusters that allowed quantification of subcluster topology. In summary, we established a standardized near-to-native preparation and immunohistochemistry protocol for SMLM analyses of AZ protein clusters in a defined model synapse. Our protocol could be adapted to study protein arrangements at single-molecule resolution in other intact tissue preparations.
Ouagadougou and Bobo-Dioulasso remain the two major urban centers in Burkina Faso with an increasing trend in human footprint. The research aimed at analyzing the Land Use/Land Cover (LULC) dynamics in the two cities between 2003 and 2021 using intensity analysis, which decomposes LULC changes into interval, category and transition levels. The satellite data used for this research were composed of surface reflectance imagery from Landsat 5, Landsat 7 and Landsat 8 acquired from the Google Earth Engine Data Catalogue. The Random Forest, Support Vector Machine and Gradient Tree Boost algorithms were employed to run supervised image classifications for four selected years including 2003, 2009, 2015 and 2021. The results showed that the landscape is changing in both cities due to rapid urbanization. Ouagadougou experienced more rapid changes than Bobo-Dioulasso, with a maximum annual change intensity of 3.61% recorded between 2015 and 2021 against 2.22% in Bobo-Dioulasso for the period 2009–2015. The transition of change was mainly towards built-up areas, which gain targeted bare and agricultural lands in both cities. This situation has led to a 78.12% increase of built-up surfaces in Ouagadougou, while 42.24% of agricultural land area was lost. However, in Bobo-Dioulasso, the built class has increased far more by 140.67%, and the agricultural land areas experienced a gain of 1.38% compared with the 2003 baseline. The study demonstrates that the human footprint is increasing in both cities making the inhabitants vulnerable to environmental threats such as flooding and the effect of an Urban Heat Island, which is information that could serve as guide for sustainable urban land use planning.
Covalent peptidomimetic protease inhibitors have gained a lot of attention in drug development in recent years. They are designed to covalently bind the catalytically active amino acids through electrophilic groups called warheads. Covalent inhibition has an advantage in terms of pharmacodynamic properties but can also bear toxicity risks due to non-selective off-target protein binding. Therefore, the right combination of a reactive warhead with a well-suited peptidomimetic sequence is of great importance. Herein, the selectivities of well-known warheads combined with peptidomimetic sequences suited for five different proteases were investigated, highlighting the impact of both structure parts (warhead and peptidomimetic sequence) for affinity and selectivity. Molecular docking gave insights into the predicted binding modes of the inhibitors inside the binding pockets of the different enzymes. Moreover, the warheads were investigated by NMR and LC-MS reactivity assays against serine/threonine and cysteine nucleophile models, as well as by quantum mechanics simulations.
Efficient redirection of NK cells by genetic modification with chemokine receptors CCR4 and CCR2B
(2023)
Natural killer (NK) cells are a subset of lymphocytes that offer great potential for cancer immunotherapy due to their natural anti-tumor activity and the possibility to safely transplant cells from healthy donors to patients in a clinical setting. However, the efficacy of cell-based immunotherapies using both T and NK cells is often limited by a poor infiltration of immune cells into solid tumors. Importantly, regulatory immune cell subsets are frequently recruited to tumor sites. In this study, we overexpressed two chemokine receptors, CCR4 and CCR2B, that are naturally found on T regulatory cells and tumor-resident monocytes, respectively, on NK cells. Using the NK cell line NK-92 as well as primary NK cells from peripheral blood, we show that genetically engineered NK cells can be efficiently redirected using chemokine receptors from different immune cell lineages and migrate towards chemokines such as CCL22 or CCL2, without impairing the natural effector functions. This approach has the potential to enhance the therapeutic effect of immunotherapies in solid tumors by directing genetically engineered donor NK cells to tumor sites. As a future therapeutic option, the natural anti-tumor activity of NK cells at the tumor sites can be increased by co-expression of chemokine receptors with chimeric antigen receptors (CAR) or T cell receptors (TCR) on NK cells can be performed in the future.
Monoglyceride lipase (MGL) hydrolyzes monoacylglycerols (MG) to glycerol and one fatty acid. Among the various MG species, MGL also degrades 2-arachidonoylglycerol, the most abundant endocannabinoid and potent activator of the cannabinoid receptors 1 and 2. We investigated the consequences of MGL deficiency on platelet function using systemic (Mgl\(^{−/−}\)) and platelet-specific Mgl-deficient (platMgl\(^{−/−}\)) mice. Despite comparable platelet morphology, loss of MGL was associated with decreased platelet aggregation and reduced response to collagen activation. This was reflected by reduced thrombus formation in vitro, accompanied by a longer bleeding time and a higher blood volume loss. Occlusion time after FeCl\(_3\)-induced injury was markedly reduced in Mgl\(^{−/−}\) mice, which is consistent with contraction of large aggregates and fewer small aggregates in vitro. The absence of any functional changes in platelets from platMgl\(^{−/−}\) mice is in accordance with lipid degradation products or other molecules in the circulation, rather than platelet-specific effects, being responsible for the observed alterations in Mgl\(^{−/−}\) mice. We conclude that genetic deletion of MGL is associated with altered thrombogenesis.
At the beginning of the COVID-19 pandemic, patients with primary and secondary immune disorders — including patients suffering from cancer — were generally regarded as a high-risk population in terms of COVID-19 disease severity and mortality. By now, scientific evidence indicates that there is substantial heterogeneity regarding the vulnerability towards COVID-19 in patients with immune disorders. In this review, we aimed to summarize the current knowledge about the effect of coexistent immune disorders on COVID-19 disease severity and vaccination response. In this context, we also regarded cancer as a secondary immune disorder. While patients with hematological malignancies displayed lower seroconversion rates after vaccination in some studies, a majority of cancer patients’ risk factors for severe COVID-19 disease were either inherent (such as metastatic or progressive disease) or comparable to the general population (age, male gender and comorbidities such as kidney or liver disease). A deeper understanding is needed to better define patient subgroups at a higher risk for severe COVID-19 disease courses. At the same time, immune disorders as functional disease models offer further insights into the role of specific immune cells and cytokines when orchestrating the immune response towards SARS-CoV-2 infection. Longitudinal serological studies are urgently needed to determine the extent and the duration of SARS-CoV-2 immunity in the general population, as well as immune-compromised and oncological patients.
Extracellular vesicles (EVs) are a heterogenous population of plasma membrane-surrounded particles that are released in the extracellular milieu by almost all types of living cells. EVs are key players in intercellular crosstalk, both locally and systemically, given that they deliver their cargoes (consisting of proteins, lipids, mRNAs, miRNAs, and DNA fragments) to target cells, crossing biological barriers. Those mechanisms further trigger a wide range of biological responses. Interestingly, EV phenotypes and cargoes and, therefore, their functions, stem from their specific parental cells. For these reasons, EVs have been proposed as promising candidates for EV-based, cell-free therapies. One of the new frontiers of cell-based immunotherapy for the fight against refractory neoplastic diseases is represented by genetically engineered chimeric antigen receptor T (CAR-T) lymphocytes, which in recent years have demonstrated their effectiveness by reaching commercialization and clinical application for some neoplastic diseases. CAR-T-derived EVs represent a recent promising development of CAR-T immunotherapy approaches. This crosscutting innovative strategy is designed to exploit the advantages of genetically engineered cell-based immunotherapy together with those of cell-free EVs, which in principle might be safer and more efficient in crossing biological and tumor-associated barriers. In this review, we underlined the potential of CAR-T-derived EVs as therapeutic agents in tumors.
Non-small cell lung cancer, ovarian cancer, and pancreatic cancer all present with high morbidity and mortality. Systemic chemotherapies have historically been the cornerstone of standard of care (SOC) regimens for many cancers, but are associated with systemic toxicity. Multimodal treatment combinations can help improve patient outcomes; however, implementation is limited by additive toxicities and potential drug–drug interactions. As such, there is a high unmet need to develop additional therapies to enhance the efficacy of SOC treatments without increasing toxicity. Tumor Treating Fields (TTFields) are electric fields that exert physical forces to disrupt cellular processes critical for cancer cell viability and tumor progression. The therapy is locoregional and is delivered noninvasively to the tumor site via a portable medical device that consists of field generator and arrays that are placed on the patient’s skin. As a noninvasive treatment modality, TTFields therapy-related adverse events mainly consist of localized skin reactions, which are manageable with effective acute and prophylactic treatments. TTFields selectively target cancer cells through a multi-mechanistic approach without affecting healthy cells and tissues. Therefore, the application of TTFields therapy concomitant with other cancer treatments may lead to enhanced efficacy, with low risk of further systemic toxicity. In this review, we explore TTFields therapy concomitant with taxanes in both preclinical and clinical settings. The summarized data suggest that TTFields therapy concomitant with taxanes may be beneficial in the treatment of certain cancers.
Prevention of the effectiveness of anti-tumor immune responses is one of the canonical cancer hallmarks. The competition for crucial nutrients within the tumor microenvironment (TME) between cancer cells and immune cells creates a complex interplay characterized by metabolic deprivation. Extensive efforts have recently been made to understand better the dynamic interactions between cancer cells and surrounding immune cells. Paradoxically, both cancer cells and activated T cells are metabolically dependent on glycolysis, even in the presence of oxygen, a metabolic process known as the Warburg effect. The intestinal microbial community delivers various types of small molecules that can potentially augment the functional capabilities of the host immune system. Currently, several studies are trying to explore the complex functional relationship between the metabolites secreted by the human microbiome and anti-tumor immunity. Recently, it has been shown that a diverse array of commensal bacteria synthetizes bioactive molecules that enhance the efficacy of cancer immunotherapy, including immune checkpoint inhibitor (ICI) treatment and adoptive cell therapy with chimeric antigen receptor (CAR) T cells. In this review, we highlight the importance of commensal bacteria, particularly of the gut microbiota-derived metabolites that are capable of shaping metabolic, transcriptional and epigenetic processes within the TME in a therapeutically meaningful way.
A variety of in vitro dissolution and gastrointestinal transfer models have been developed aiming to predict drug supersaturation and precipitation. Further, biphasic, one-vessel in vitro systems are increasingly applied to simulate drug absorption in vitro. However, to date, there is a lack of combining the two approaches. Therefore, the first aim of this study was to develop a dissolution-transfer-partitioning system (DTPS) and, secondly, to assess its biopredictive power. In the DTPS, simulated gastric and intestinal dissolution vessels are connected via a peristaltic pump. An organic layer is added on top of the intestinal phase, serving as an absorptive compartment. The predictive power of the novel DTPS was assessed to a classical USP II transfer model using a BCS class II weak base with poor aqueous solubility, MSC-A. The classical USP II transfer model overestimated simulated intestinal drug precipitation, especially at higher doses. By applying the DTPS, a clearly improved estimation of drug supersaturation and precipitation and an accurate prediction of the in vivo dose linearity of MSC-A were observed. The DTPS provides a useful tool taking both dissolution and absorption into account. This advanced in vitro tool offers the advantage of streamlining the development process of challenging compounds.
The best characterized polyomavirus family member, i.e., simian virus 40 (SV40), can cause different tumors in hamsters and can transform murine and human cells in vitro. Hence, the SV40 contamination of millions of polio vaccine doses administered from 1955–1963 raised fears that this may cause increased tumor incidence in the vaccinated population. This is, however, not the case. Indeed, up to now, the only polyomavirus family member known to be the most important cause of a specific human tumor entity is Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma (MCC). MCC is a highly deadly form of skin cancer for which the cellular origin is still uncertain, and which appears as two clinically very similar but molecularly highly different variants. While approximately 80% of cases are found to be associated with MCPyV the remaining MCCs carry a high mutational load. Here, we present an overview of the multitude of molecular functions described for the MCPyV encoded oncoproteins and non-coding RNAs, present the available MCC mouse models and discuss the increasing evidence that both, virus-negative and -positive MCC constitute epithelial tumors.
(1) Background: Evaluation of impact of adjuvant radiation therapy (RT) in patients with oral squamous cell carcinoma of the oral cavity/oropharynx (OSCC) of up to 4 cm (pT1/pT2) and solitary ipsilateral lymph node metastasis (pN1). A non-irradiated group with clinical follow-up was chosen for control, and survival and quality of life (QL) were compared; (2) Methods: This prospective multicentric comprehensive cohort study included patients with resected OSCC (pT1/pT2, pN1, and cM0) who were allocated into adjuvant radiation therapy (RT) or observation. The primary endpoint was overall survival. Secondary endpoints were progression-free survival and QL after surgery; (3) Results: Out of 27 centers, 209 patients were enrolled with a median follow-up of 3.4 years. An amount of 137 patients were in the observation arm, and 72 received adjuvant irradiation. Overall survival did not differ between groups (hazard ratio (HR) 0.98 [0.55–1.73], p = 0.94). There were fewer neck metastases (HR 0.34 [0.15–0.77]; p = 0.01), as well as fewer local recurrences (HR 0.41 [0.19–0.89]; p = 0.02) under adjuvant RT. For QL, irradiated patients showed higher values for the symptom scale pain after 0.5, two, and three years (all p < 0.05). After six months and three years, irradiated patients reported higher symptom burdens (impaired swallowing, speech, as well as teeth-related problems (all p < 0.05)). Patients in the RT group had significantly more problems with mouth opening after six months, one, and two years (p < 0.05); (4) Conclusions: Adjuvant RT in patients with early SCC of the oral cavity and oropharynx does not seem to influence overall survival, but it positively affects progression-free survival. However, irradiated patients report a significantly decreased QL up to three years after therapy compared to the observation group.
(1) Background: Clear cell renal cell carcinoma extending into the inferior vena cava (ccRCC\(^{IVC}\)) represents a clinical high-risk setting. However, there is substantial heterogeneity within this patient subgroup regarding survival outcomes. Previously, members of our group developed a microRNA(miR)-based risk classifier — containing miR-21-5p, miR-126-3p and miR-221-3p expression — which significantly predicted the cancer-specific survival (CSS) of ccRCC\(^{IVC}\) patients. (2) Methods: Examining a single-center cohort of tumor tissue from n = 56 patients with ccRCC\(^{IVC}\), we measured the expression levels of miR-21, miR-126, and miR-221 using qRT-PCR. The prognostic impact of clinicopathological parameters and miR expression were investigated via single-variable and multivariable Cox regression. Referring to the previously established risk classifier, we performed Kaplan–Meier analyses for single miR expression levels and the combined risk classifier. Cut-off values and weights within the risk classifier were taken from the previous study. (3) Results: miR-21 and miR-126 expression were significantly associated with lymphonodal status at the time of surgery, the development of metastasis during follow-up, and cancer-related death. In Kaplan–Meier analyses, miR-21 and miR-126 significantly impacted CSS in our cohort. Moreover, applying the miR-based risk classifier significantly stratified ccRCC\(^{IVC}\) according to CSS. (4) Conclusions: In our retrospective analysis, we successfully validated the miR-based risk classifier within an independent ccRCC\(^{IVC}\) cohort.
Aggression and deficient cognitive control problems are widespread in psychiatric disorders, including major depressive disorder (MDD). These abnormalities are known to contribute significantly to the accompanying functional impairment and the global burden of disease. Progress in the development of targeted treatments of excessive aggression and accompanying symptoms has been limited, and there exists a major unmet need to develop more efficacious treatments for depressed patients. Due to the complex nature and the clinical heterogeneity of MDD and the lack of precise knowledge regarding its pathophysiology, effective management is challenging. Nonetheless, the aetiology and pathophysiology of MDD has been the subject of extensive research and there is a vast body of the latest literature that points to new mechanisms for this disorder. Here, we overview the key mechanisms, which include neuroinflammation, oxidative stress, insulin receptor signalling and abnormal myelination. We discuss the hypotheses that have been proposed to unify these processes, as many of these pathways are integrated for the neurobiology of MDD. We also describe the current translational approaches in modelling depression, including the recent advances in stress models of MDD, and emerging novel therapies, including novel approaches to management of excessive aggression, such as anti-diabetic drugs, antioxidant treatment and herbal compositions.
Developmentally regulated features of innate immunity are thought to place preterm and term infants at risk of infection and inflammation-related morbidity. Underlying mechanisms are incompletely understood. Differences in monocyte function including toll-like receptor (TLR) expression and signaling have been discussed. Some studies point to generally impaired TLR signaling, others to differences in individual pathways. In the present study, we assessed mRNA and protein expression of pro- and anti-inflammatory cytokines in preterm and term cord blood (CB) monocytes compared with adult controls stimulated ex vivo with Pam3CSK4, zymosan, polyinosinic:polycytidylic acid, lipopolysaccharide, flagellin, and CpG oligonucleotide, which activate the TLR1/2, TLR2/6, TLR3, TLR4, TLR5, and TLR9 pathways, respectively. In parallel, frequencies of monocyte subsets, stimulus-driven TLR expression, and phosphorylation of TLR-associated signaling molecules were analyzed. Independent of stimulus, pro-inflammatory responses of term CB monocytes equaled adult controls. The same held true for preterm CB monocytes—except for lower IL-1β levels. In contrast, CB monocytes released lower amounts of anti-inflammatory IL-10 and IL-1ra, resulting in higher ratios of pro-inflammatory to anti-inflammatory cytokines. Phosphorylation of p65, p38, and ERK1/2 correlated with adult controls. However, stimulated CB samples stood out with higher frequencies of intermediate monocytes (CD14\(^+\)CD16\(^+\)). Both pro-inflammatory net effect and expansion of the intermediate subset were most pronounced upon stimulation with Pam3CSK4 (TLR1/2), zymosan (TR2/6), and lipopolysaccharide (TLR4). Our data demonstrate robust pro-inflammatory and yet attenuated anti-inflammatory responses in preterm and term CB monocytes, along with imbalanced cytokine ratios. Intermediate monocytes, a subset ascribed pro-inflammatory features, might participate in this inflammatory state.
The parotid gland is one of the major salivary glands producing a serous secretion, and it plays an essential role in the digestive and immune systems. Knowledge of peroxisomes in the human parotid gland is minimal; furthermore, the peroxisomal compartment and its enzyme composition in the different cell types of the human parotid gland have never been subjected to a detailed investigation. Therefore, we performed a comprehensive analysis of peroxisomes in the human parotid gland’s striated duct and acinar cells. We combined biochemical techniques with various light and electron microscopy techniques to determine the localization of parotid secretory proteins and different peroxisomal marker proteins in parotid gland tissue. Moreover, we analyzed the mRNA of numerous gene encoding proteins localized in peroxisomes using real-time quantitative PCR. The results confirm the presence of peroxisomes in all striated duct and acinar cells of the human parotid gland. Immunofluorescence analyses for various peroxisomal proteins showed a higher abundance and more intense staining in striated duct cells compared to acinar cells. Moreover, human parotid glands comprise high quantities of catalase and other antioxidative enzymes in discrete subcellular regions, suggesting their role in protection against oxidative stress. This study provides the first thorough description of parotid peroxisomes in different parotid cell types of healthy human tissue.
In spinal muscular atrophy (SMA), mutations in or loss of the Survival Motor Neuron 1 (SMN1) gene reduce full-length SMN protein levels, which leads to the degeneration of a percentage of motor neurons. In mouse models of SMA, the development and maintenance of spinal motor neurons and the neuromuscular junction (NMJ) function are altered. Since nifedipine is known to be neuroprotective and increases neurotransmission in nerve terminals, we investigated its effects on cultured spinal cord motor neurons and motor nerve terminals of control and SMA mice. We found that application of nifedipine increased the frequency of spontaneous Ca\(^{2+}\) transients, growth cone size, cluster-like formations of Cav2.2 channels, and it normalized axon extension in SMA neurons in culture. At the NMJ, nifedipine significantly increased evoked and spontaneous release at low-frequency stimulation in both genotypes. High-strength stimulation revealed that nifedipine increased the size of the readily releasable pool (RRP) of vesicles in control but not SMA mice. These findings provide experimental evidence about the ability of nifedipine to prevent the appearance of developmental defects in SMA embryonic motor neurons in culture and reveal to which extent nifedipine could still increase neurotransmission at the NMJ in SMA mice under different functional demands.
By virtue of mitochondrial control of energy production, reactive oxygen species (ROS) generation, and maintenance of Ca\(^{2+}\) homeostasis, mitochondria play an essential role in modulating T cell function. The mitochondrial Ca\(^{2+}\) uniporter (MCU) is the pore-forming unit in the main protein complex mediating mitochondrial Ca\(^{2+}\) uptake. Recently, MCU has been shown to modulate Ca\(^{2+}\) signals at subcellular organellar interfaces, thus fine-tuning NFAT translocation and T cell activation. The mechanisms underlying this modulation and whether MCU has additional T cell subpopulation-specific effects remain elusive. However, mice with germline or tissue-specific ablation of Mcu did not show impaired T cell responses in vitro or in vivo, indicating that ‘chronic’ loss of MCU can be functionally compensated in lymphocytes. The current work aimed to specifically investigate whether and how MCU influences the suppressive potential of regulatory CD4 T cells (Treg). We show that, in contrast to genetic ablation, acute siRNA-mediated downregulation of Mcu in murine Tregs results in a significant reduction both in mitochondrial Ca\(^{2+}\) uptake and in the suppressive capacity of Tregs, while the ratios of Treg subpopulations and the expression of hallmark transcription factors were not affected. These findings suggest that permanent genetic inactivation of MCU may result in compensatory adaptive mechanisms, masking the effects on the suppressive capacity of Tregs.
Preterm infants are susceptible to infection and their defense against pathogens relies largely on innate immunity. The role of the complement system for the immunological vulnerability of preterm infants is less understood. Anaphylatoxin C5a and its receptors C5aR1 and -2 are known to be involved in sepsis pathogenesis, with C5aR1 mainly exerting pro-inflammatory effects. Our explorative study aimed to determine age-dependent changes in the expression of C5aR1 and C5aR2 in neonatal immune cell subsets. Via flow cytometry, we analyzed the expression pattern of C5a receptors on immune cells isolated from peripheral blood of preterm infants (n = 32) compared to those of their mothers (n = 25). Term infants and healthy adults served as controls. Preterm infants had a higher intracellular expression of C5aR1 on neutrophils than control individuals. We also found a higher expression of C5aR1 on NK cells, particularly on the cytotoxic CD56\(^{dim}\) subset and the CD56\(^-\) subset. Immune phenotyping of other leukocyte subpopulations revealed no gestational-age-related differences for the expression of and C5aR2. Elevated expression of C5aR1 on neutrophils and NK cells in preterm infants may contribute to the phenomenon of “immunoparalysis” caused by complement activation or to sustained hyper-inflammatory states. Further functional analyses are needed to elucidate the underlying mechanisms.
In a recent study, we showed in an in vitro murine cerebellar microvascular endothelial cell (cerebEND) model as well as in vivo in rats that Tumor-Treating Fields (TTFields) reversibly open the blood–brain barrier (BBB). This process is facilitated by delocalizing tight junction proteins such as claudin-5 from the membrane to the cytoplasm. In investigating the possibility that the same effects could be observed in human-derived cells, a 3D co-culture model of the BBB was established consisting of primary microvascular brain endothelial cells (HBMVEC) and immortalized pericytes, both of human origin. The TTFields at a frequency of 100 kHz administered for 72 h increased the permeability of our human-derived BBB model. The integrity of the BBB had already recovered 48 h post-TTFields, which is earlier than that observed in cerebEND. The data presented herein validate the previously observed effects of TTFields in murine models. Moreover, due to the fact that human cell-based in vitro models more closely resemble patient-derived entities, our findings are highly relevant for pre-clinical studies.