Refine
Has Fulltext
- yes (214)
Is part of the Bibliography
- yes (214)
Year of publication
- 1993 (214) (remove)
Document Type
- Journal article (160)
- Book article / Book chapter (27)
- Conference Proceeding (11)
- Review (8)
- Book (4)
- Complete part of issue (2)
- Jahresbericht (1)
- Other (1)
Keywords
- Anorganische Chemie (11)
- Toxikologie (11)
- Organische Chemie (8)
- Physiologische Chemie (8)
- Immunologie (7)
- Psychologie (6)
- Virologie (6)
- Biochemie (5)
- Infektionsbiologie (4)
- Neurobiologie (4)
- 1 (3)
- Aufmerksamkeit (3)
- Kongress (3)
- Medizin (3)
- Würzburg (3)
- 3 (2)
- Anatolien (2)
- Baden (2)
- Biologie (2)
- Chemie (2)
- Chirurgie (2)
- Diels-Alder reactions (2)
- Durchblutung (2)
- Erziehung (2)
- Frauenarbeit (2)
- Gehirn (2)
- Geographie (2)
- Immunbiologie (2)
- Kind (2)
- Leonhard classification (2)
- Leonhard-Klassifikation (2)
- Lernpsychologie (2)
- Lower Franconia (2)
- Längsschnittuntersuchung (2)
- Micronuclei (2)
- Niger (2)
- Physik (2)
- Psychiatrie (2)
- Romanistik (2)
- Schizophrenie (2)
- Sprachatlas (2)
- Tell Jikan (2)
- Tell Khirbet Salih (2)
- Universität (2)
- Unterfranken (2)
- Zeitschrift (2)
- cytoskeleton (2)
- linguistic atlas (2)
- rats (2)
- 15-Deoxyspergualin (1)
- 1990> (1)
- 2-Acetylaminofluorene (1)
- 2-Bismethylenecyclohexane (1)
- 2-Cyclopentanedione derivatives (1)
- 2-Dioxetane (1)
- 29Si and 15N (1)
- 4-0xadiazin-6-ones (1)
- 4-0xadiazine-2-carboxylate (1)
- 4]0xadiazino[4 (1)
- 4]non-7-en-6-ylpotassium (1)
- 5-Azacytidine (1)
- 5-b]isoquinolin-1-one derivatives (1)
- 6-phenyl (1)
- 6H-1 (1)
- Acquisition of literacy (1)
- Adhesion (1)
- Adipic acid (1)
- Affective psychoses (1)
- Alkohol (1)
- Alter Orient (1)
- Altes Testament (1)
- Altfranzösisch (1)
- Anchimeric assistance in solvolysis (1)
- Annual Report (1)
- Antikörper (1)
- Antizipation (1)
- Archäologie (1)
- Arterioles (submucosal) (1)
- Astrocytes ; Schwann cells ; Interferon-gamma ; Fibroblast growth factor ; Cyclic AMP (1)
- Asymmetrie (1)
- Aufsatzsammlung (1)
- Ausgrabung (1)
- Auto-antibodies (1)
- Automation (1)
- Automatismus (1)
- Bauchspeicheldrüse (1)
- Begriff (1)
- Benzefuran dioxetane (1)
- Benzefuran epoxide (1)
- Berenil (1)
- Bericht (1)
- Bewegungssteuerung (1)
- Bicyclo[1.1.0]butylcarbinyl sulfonates (1)
- Bicyclo[2.1.l]hexan-5-one (1)
- Bicyclo[3.2.1]oct-3-en-2-yl anions (1)
- Bis[1,2-benzendiolato(2-)][(morpholinio)alkyl]silicates (1)
- Bis[2,3-naphthalenediolato(2-)][(morpholinio)alkyl]silicates (1)
- Blutalkohol (1)
- Bond cleavage (1)
- CNTF (1)
- Calcium (1)
- Carcinogenität (1)
- Cardiac myocyte ; Beta-Receptor ; Muscarinic receptor ; cAMP ; G-protein ; Serum (1)
- Children-at-Risk (1)
- Chromosome distribution (1)
- Churritisch (1)
- Cyanobacteria (1)
- Cyclobutylcarbinyl sulfonates (1)
- Cytologie (1)
- DES (1)
- DNA adduct . Repair endonuclease (1)
- DNA damage (1)
- DNS (1)
- DNS-Bindung (1)
- DNS-Schädigung (1)
- Darm (1)
- Diethylstilbestrol (1)
- Dose response (1)
- Early infant catatonia (1)
- Electron demand in ditosylates (1)
- Elucidarium (1)
- Emotionality (1)
- Environment (1)
- Ernährung (1)
- Escherichia coli (1)
- Ethik (1)
- Ethionine (1)
- Extracellular domain (1)
- FGF-5 (1)
- FPG protein (1)
- Facial Nerve Transection (1)
- Fibroblast Growth Factor (1)
- Fimbriae (1)
- Fingerprint-Verfahren (1)
- Frühkindliche Katatonie (1)
- Fulgurite (1)
- G proteins (1)
- GBS (1)
- Gedächtnis (1)
- Gedächtnisleistung (1)
- Gene regulation (1)
- Geschichte 2000 v. Chr.-331 v. Chr (1)
- Goldbrasse (1)
- HIV-Infektion (1)
- Hamburg (1)
- Hamburg <1990> (1)
- Harnwegsinfekt (1)
- Heterotransplantation (1)
- Hirnhautentzündung (1)
- Histologie (1)
- Hochbegabung (1)
- Holocene (1)
- Homoaromaticity in carbanions (1)
- Honorius <Augustodunensis> (1)
- Human foamy virus bel-l transactivator; Expression in insect cells (1)
- Hyperfine coupling constants (1)
- IGF-I (1)
- Identitätsentwicklung (1)
- Ileum; Atrium (1)
- Immunopanning (1)
- Immunsystem (1)
- Indirect and direct contributions to A<sub>iso</sub> (1)
- Infektion (1)
- Infektionserreger (1)
- Infektionskrankheit (1)
- Influence of excitation classes (1)
- Insulinlike Growth Factor (1)
- Interaktion (1)
- Isolierung <Mikrobiologie> (1)
- Jahresbericht (1)
- Karyotype; chromosome banding; Desertellio elongatus; Crustacea; Isopoda; Oniscidea (1)
- Ketenes (1)
- Kidney (perfused (1)
- Kinetochore (1)
- Klassische Archäologie (1)
- Kognitive Psychologie (1)
- Kollagenase (1)
- Kongreß (1)
- Kontinentales Tiefbohrprogramm (1)
- Krebs <Medizin> (1)
- L5178Y cells (1)
- Lambda5-organofluorosilicate (1)
- Langerhans cell (1)
- Langerhans-Inseln (1)
- Lebendgebärende Zahnkarpfen (1)
- Legionella pneumophila (1)
- Leishmania major (1)
- Leistung (1)
- Leistungssport (1)
- Leonhard cIassification (1)
- Lese- und Schreibfähigkeit (1)
- Lesen (1)
- Light stimulation (1)
- M2 muscarinic receptors (1)
- Maghreb; Geschichte; Europa (1)
- Melanom (1)
- Memory capacity (1)
- Methode (1)
- Mitosis (1)
- Mittelalter (1)
- Molekularpathologie (1)
- Motorische Entwicklung (1)
- Mund-Kiefer-Gesichts-Chirurgie (1)
- Muscarinic receptor agonists (1)
- Muscarinic receptor antagonists (1)
- Musik ; Nationalsozialismus ; Konzentrationslager (1)
- Mutagenicity (1)
- Mutation assay (1)
- NAD(P)H-dehydrogenase (1)
- NAD(P)H-plastoquinone-oxidoreductase (1)
- NDH-H (1)
- NDH-I (1)
- NDH-J (1)
- NDH-K (1)
- NGF gene family (1)
- Neolithic (1)
- Neuritis (1)
- Neurologie (1)
- Neurotrophin (1)
- Noise stimulation (1)
- Nucleolus-DNA (1)
- Onkogen (1)
- Oralchirurgie (1)
- PO (1)
- Pain threshold ; Smoking ; Nicotine ; Acute tolerance ; Deprivation ; Psychophysiologicat measures (1)
- Persönlichkeitsentwicklung (1)
- Pharmakologie (1)
- Phonological awareness (1)
- Phonologische Bewusstheit (1)
- Plastid DNA (1)
- Predigt (1)
- Prognose (1)
- Psychopathologie (1)
- Rat (1)
- Rauschgift (1)
- Rearrangement of carbocations (1)
- Recombinant DNA ; Growth hormone gene ; PCR; Silver carp ; Fish (1)
- Religion (1)
- Report (1)
- Retroviren-Infektion (1)
- Rezeption (1)
- Ringberg <Tegernsee (1)
- Saarbrücken <1992> (1)
- Sahara (1)
- Schizophrenia (1)
- Schreiben (1)
- Schwangerschaft (1)
- Schwein (1)
- Schwertkärpfling (1)
- Si-C I Solid-state NMR (1)
- Silicate (1)
- Silicon (1)
- Social activity (1)
- Somatotropin (1)
- Sonderpädagogik (1)
- Sparus aurata (1)
- Spin density (1)
- Spirosilicates (1)
- Sportmotorik (1)
- Sportpsychologie (1)
- Stress (1)
- Stressreaktion (1)
- Styrol (1)
- Synechocystis sp. PCC6803 (1)
- Syrisch-palästinensischer Raum (1)
- T-cell (1)
- Techniktraining (1)
- Tell Karrana (1)
- Tiermodell (1)
- Tierversuch (1)
- Transcription (1)
- Transgene Tiere (1)
- Transgenic mouse (1)
- Tricyclo[3.3.1.0 2 (1)
- University Library (1)
- Universitätsbibliothek (1)
- Unterbewusstsein (1)
- Urartäisch (1)
- Vas deferens (1)
- Verhaltenssteuerung (1)
- Von Mises conditions (1)
- Wachstum (1)
- Wachstumskonus (1)
- Wahrnehmung (1)
- Wilson Terrane ; intrusions ; mafic composition ; relative age ; petrographic analysis ; gabbroic composition ; subduction zones (1)
- Wissensliteratur (1)
- Wissensrepräsentation (1)
- Wuerzburg (1)
- Wurzburg (1)
- Zellskelett (1)
- Zellteilung (1)
- Zwitterionic (1)
- Zwitterionic [lambda]5-Spirosilicates (1)
- [1 (1)
- actin (1)
- all-fish genes (1)
- apoptosis (1)
- benzodiazepine antagonist. (1)
- binding (1)
- bone marrow (1)
- calcium (1)
- camptothecin (1)
- cardiac myocyte ; muscarinic K current ; G-protein ; Albumin ; serum (1)
- cellline transfection (1)
- cerebraI ischemia (1)
- chemotaxis (1)
- ciliary-neurotrophic factor (1)
- climatic change (1)
- crystal structure (1)
- cytokines (1)
- demyelination (1)
- dermorphin (1)
- drug design/partial agonists (1)
- enthalpy (1)
- entropy (1)
- epitope specificity (1)
- expectation (Psychology) (1)
- experimental therapy (1)
- extreme order statistics (1)
- extreme value distribution (1)
- extreme value theory (1)
- famiIiaI ·sporadic concept (1)
- flumazenil (1)
- formyl peptides (1)
- fulgurites (1)
- gene targeting (1)
- generalized Pareto distribution (1)
- growth cone (1)
- growth hormone gene (1)
- hematology (1)
- highly substituted (1)
- human information processing (1)
- immunosuppression (1)
- in vivo (1)
- insulin (1)
- insulin-likegrowth factor I (1)
- interleukin 6 (1)
- lIF (1)
- lightning (1)
- lipopolysaccharides (1)
- membrane skeleton (1)
- mental Processes (1)
- methyl 6-oxo-5-phenyl- (1)
- mitosis (1)
- monopolar depressive disorders (1)
- monopolare endogene Depression (1)
- myelin (1)
- ndhH gene (1)
- neuronal damage (1)
- neurotrophic molecules (1)
- neurotrophins (1)
- obstetric complications (1)
- open field behaviour (1)
- opioid receptors (1)
- opioid-benzodiazepine interactions (1)
- opoisomerase I (1)
- palaeosols (1)
- pentacoordinate (1)
- pentacoordinate silicon (1)
- peripheral nervous system (1)
- phenyl-substituted (1)
- platelet activating factor (1)
- programmed cell death (1)
- psychopathology (1)
- rat pheochromocytoma cells (1)
- rat) (1)
- receptor signalling (1)
- receptors (1)
- regeneration (1)
- reproductive success (1)
- respiration (1)
- schizophrenia (1)
- sexual selection (1)
- simple repetitive sequences (1)
- size polymorpbism (1)
- sodal domlnance (1)
- solvolysis of (1)
- substituted 2-oxo- dimethyl esters (1)
- thermodynamics (1)
- thunderstorms (1)
- trans-activation (1)
- transgenic fish (1)
- tumor necrosis factor (1)
- van 't Hoff plot (1)
- y-oxo- (1)
- zwitterionic (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (28)
- Institut für Psychologie (bis Sept. 2007) (24)
- Institut für Pharmakologie und Toxikologie (20)
- Institut für Anorganische Chemie (17)
- Institut für Virologie und Immunbiologie (16)
- Institut für Molekulare Infektionsbiologie (13)
- Physikalisches Institut (13)
- Institut für Organische Chemie (9)
- Institut für Klinische Neurobiologie (8)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (8)
- Neurochirurgische Klinik und Poliklinik (6)
- Institut für Mathematik (5)
- Institut für Psychologie (5)
- Institut für deutsche Philologie (5)
- Neuphilologisches Institut - Moderne Fremdsprachen (bis 2007) (5)
- Institut für Altertumswissenschaften (bis Sept. 2007) (4)
- Institut für Mineralogie und Kristallstrukturlehre (4)
- Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie (4)
- Institut für Geographie (3)
- Institut für romanische Philologie (3)
- Institut für Pädagogik (bis Sept. 2007) (2)
- Julius-von-Sachs-Institut für Biowissenschaften (2)
- Klinik für Anaesthesiologie (bis 2003) (2)
- Physiologisches Institut (2)
- Universität Würzburg (2)
- Institut für Altertumswissenschaften (1)
- Institut für Anatomie und Zellbiologie (1)
- Institut für Archäologie (1)
- Institut für Pharmazie und Lebensmittelchemie (1)
- Institut für Politische Wissenschaft (1)
- Institut für Sonderpädagogik (bis Sept. 2007) (1)
- Pathologisches Institut (1)
- Universitätsbibliothek (1)
No abstract available
A semiempirical model is presented that correlates the broadening of the absorption edge with both transitions below the energy gap and with transitions by the Kane band model. This model correctly fits both the absorption and luminescence spectra of narrow-gap (Hg,Cd)Te samples that have been grown by the traveling heater method as well as by molecular-beam epitaxy. The accuracy of the band-gap determination is enhanced by this model.
Available data on the occurrence and expression of somatic histone HI during oogenesis and early embryogenesis of Xenopus laevis are contradictory. In particular the reported presence of a large storage pool of histone HIA in oocytes is difficult to reconcile with the high transcriptional activity of all gene classes in this specific cell type. In the present study we have used polyclonal antibodies raised against somatic Xenopus histone HI (HIA and HIA/B) for combined immunoblotting experiments to quantitate HI pools and immunolocalization studies to visualize chromosome- bound HI. Both approaches failed to detect soluble or chromosomal histone HI in vitellogenic oocytes, eggs, and cleavage-stage embryos up to early blastula. In addition, chromatin assembled in Xenopus egg extract was also negative for histone HI as revealed by immunofluorescence microscopy. Lampbrush chromosomes not only lacked histone HI but also the previously identified histone HI-like B4 protein (Smith et al., 1988, Genes Dev. 2,1284-1295). In contrast, chromosomes of eggs and early embryos fluoresced brightly with anti-B4 antibodies. Our results lend further support to the view that histone HI expression is developmentally regulated during Xenopus oogenesis and embryogenesis similar to what is known from other species.
No abstract available
In order to develop all-fish expression vectors for microinjection into fertilized fish eggs, we have prepared the following cunstructs: rainbow trout metallothionein a/b and the gilthead seabream growth hormone cDNA (ptMTa-gbsGHcDNA, ptMTb-gsbGHcDNA), carp ß-actin gilthead seabream GH cDNA (pcAßgsbGHcDNA). The inducible metallothionein promoters a and b were cloned from rainbow trout, and the constitutive promoter ß-actin was isolated from carp. The metallothionein promoters were cloned by using the PCR technique. The tMTa contains 430 bp, while the tMTb contains 260 bp (Hong et al. 1992). These two promoters were introduced to pGEM-3Z containing the GH cDNA of Sparus aurata to form ptMTa-gsbGH and ptMTb-gsbGH, respectively. The carp cytoplasmic ß-actin gene was chosen as a source for isolating strong constitutive regulatory sequences. One of these regulatory sequences in pUC118 was Iigated to GH cDNA of S. aurata to form the pcAß-gsbGHcDNA. Expression of the constructs containing the metallothionein promoters was tested in fish cell culture and was found tobe induced effectively by zinc. The ptMTa gsb-GH cDNA construct was microinjected into fertilized carp eggs, and integration in the genome of carp was detected in the DNA isolated from fins at the age of two months.
The role of the thymus in the pathogenesis of simian acquired immunodeficiency syndrome was investigated in 18 juvenile rhesus monkeys (Macaca mulatta). The thymus was infected from the first week post-SIVmac inoculation, but the amount of virus-positive cells was very low « 1 in 1 04 T cells) as demonstrated by polymerase chain reaction and in situ hybridization. First morphological alteration was a narrowing of the cortex at 12 and 24 wpi. Morphometry revealed no increase of pyknotic T cells but a decrease of the proliferation rate andflow cytometry showed a reduction of the immature \(CD4^+/CD8^+\) double-positive T cells. Ultrastructural analysis revealed vacuolization, shrinkage, andfinally cytolysis of the cortical epithelial cells and the interdigitating dendritic cells. Immunofluorescence staining exhibited a widespread loss of cortical epithelial cells. This damage to the thymic microenvironment could explain the breakdown of the intrathymic T cell proliferation. It preceded fully developed simian acquired immunodeficiency syndrome and is therefore considered to play a major role in its pathogenesis.
In distance geometry problems and many other applications, we are faced with the optimization of high-dimensional quadratic functions subject to linear equality constraints. A new approach is presented that projects the constraints, preserving sparsity properties of the original quadratic form such that well-known preconditioning techniques for the conjugate gradient method remain applicable. Very-largescale cell placement problems in chip design have been solved successfully with diagonal and incomplete Cholesky preconditioning. Numerical results produced by a FORTRAN 77 program illustrate the good behaviour of the algorithm.
An improved 32P-postlabelling assay for detection and quantitation of styrene 7,8-oxide-DNA adducts
(1993)
Using DNA modified with [7-3H]styrene 7,8-oxide (SO) in vitro we have standardized the 32P-postlabelling assay for detecting SO-DNA adducts. Nuclease P 1-enriched adducts were 32P-labelled and purified by high-salt ( 4.0 M ammonium formate, pH 6.1} C1s reverse-phase TLC. After elution from the layer with 2-butoxyethanol:H20 (4:6), adducts were separated by two-dimensional PEI cellulose TLC in non-urea solvents (2.0 M ammonium formate, pH 3.5, and 2.7 M sodium phosphate, pH 5.6). One major, three minor and several trace adducts were detected. The efficiency of the kinase reaction depended on the ATP concentration. Use of standard labelling conditions (['Y· 32P]ATP, <3000 Ci/mmol; <2 Mikromol) resulted in poor ( 4-7%) adduct recovery. An ATP concentration of 40 Mikromol, however, increased the labeJling efficiency by a factor of 5-8 (35-55% based on 3H-SO labelied DNA). The results indicate that the new separation technique is suitable for the relatively polar SO-DNA adducts and that high labelling efficiency can be achieved.
Tbe benzodiazepines are a class of d.rugs that are widely used in the treatment of various psychiatric disorders. One member of um ~' oxazepam, is also a common metabolite of sevmd other benzod.iazepines. Since the evidence for the genetic toxicity and carcinogenic properties of these compounds is incol:lsb1ent, we investigated the oxazepam-induced fonnation of micronuclei in Syrian Hamster embryo fibroblast (SHE) cells, human amniotic fluid fibroblast-like (AFFL) cells and LS178Y mouse cells. A dose-dependent increase in micronucleus fractions was found in all tbree ceU llnes. The time course of micronucleus induction in L5178Y cells showed a maximum at 5 h after treatment, suggesting that the micronuclei were fonned in the first mitosis after treatment. Kinetochore staining (CREST -antiserum) revealed the presence of kinetochores in -SO% of the micronuclei in aU tbree ceU types. ThJs resu1t was further confinned by in situ bybridization in LS178Y cells and indicates tbe presence of wbole Chromosomes or centric fragments as weU as acentric fragments in the oxazepam-induced micronuclei. The LS178Y cells did not show a mutagenic response to oxazepam at any of the doses or expression times used.
Legionella pneumophila, the causative agent of Legionnaires' disease is a facultative intracellular bacterium, which in the course of human infection multiplies in lung macrophages predominantly manifesting as pneumonia. The natural habitat of Legionella is found in sweet water reservoirs and man-made water systems. Virulent L. pneumophila spontaneously convert to an avirulent status at a high frequency. Genetic approaches have led to the identification of various L. pneumophila genes. The mip (macrophage infectivity potentiator) determinant remains at present the sole established virulence factor. The Mip protein exhibits activity of a peptidyl prolyl cis trans isomerase (PPiase), an enzyme which is able to bind the immunosuppressant FK506 and is involved in protein folding. The recently cloned major outer membrane protein (MOMP) could play a role in the uptake of legionellae by macrophages. Cellular models are useful in studying the intracellular replication of legionellae in eukaryotic cells. Human celllines and protozoan models are appropriate for this purpose. By using U 937 macrophage-like cells and Acanthamoeba castellanii as hosts, we could discriminate virulent and avirulent L. pneumophila variants since only the virulent strain was capable of intracellular growth at 37 oc. By using these systems we further demonstrated that a hemolytic factor cloned and characterized in our laboratory, legiolysin (lly), had no influence on the intracellular growth of L. pneumophila.
no abstract available