Refine
Is part of the Bibliography
- yes (378) (remove)
Year of publication
Document Type
- Doctoral Thesis (216)
- Journal article (160)
- Book (1)
- Other (1)
Keywords
- mesenchymal stem cells (15)
- Osteoporose (14)
- osteoporosis (12)
- total knee arthroplasty (12)
- Schultergelenk (11)
- Rotatorenmanschette (10)
- tissue engineering (9)
- Hüftgelenk (8)
- Mesenchymale Stammzellen (8)
- Revision (8)
- kinematic alignment (8)
- osteoarthritis (8)
- Endoprothetik (7)
- Kniegelenkprothese (7)
- Mesenchymzelle (7)
- Tissue Engineering (7)
- bone (7)
- hip (7)
- hypophosphatasia (7)
- knee (7)
- mesenchymale Stammzellen (7)
- Arthroskopie (6)
- Kniegelenk (6)
- Knieprothese (6)
- differentiation (6)
- total hip arthroplasty (6)
- Arthrose (5)
- Differenzierung (5)
- Hüftgelenkprothese (5)
- Knorpelzelle (5)
- Kreuzband (5)
- MSC (5)
- Prothese (5)
- Schulter (5)
- Stammzellen (5)
- Totalendoprothese (5)
- cartilage (5)
- knee arthroplasty (5)
- mechanotransduction (5)
- mesenchymal stem cell (5)
- osteogenic differentiation (5)
- periprosthetic infection (5)
- revision (5)
- shoulder (5)
- spacer (5)
- Adulte Stammzelle (4)
- Biomechanik (4)
- Hypophosphatasie (4)
- Hüfte (4)
- Hüftendoprothetik (4)
- Kollagen (4)
- MSCs (4)
- Omarthrose (4)
- Orthopädie (4)
- Osteoarthritis (4)
- Rheumatoide Arthritis (4)
- Schulterendoprothetik (4)
- TNAP (4)
- Zelldifferenzierung (4)
- arthroplasty (4)
- arthroscopy (4)
- bone mineral density (4)
- chondrocytes (4)
- chondrogenesis (4)
- extracellular vesicles (4)
- fracture (4)
- inflammation (4)
- phenotype (4)
- quality of life (4)
- rotator cuff tear (4)
- sarcopenia (4)
- stem cells (4)
- total knee replacement (4)
- vitamin D (4)
- ACL (3)
- Akromioklavikulargelenk (3)
- Arthrodese (3)
- Arthroplasty (3)
- CYR61 (3)
- Endoprothese (3)
- Gelenkknorpel (3)
- Hip (3)
- Hydrogel (3)
- Hypophosphatasia (3)
- Hüftprothese (3)
- Knee (3)
- Knie (3)
- Knorpel (3)
- Knorpelregeneration (3)
- Körperliche Aktivität (3)
- Langzeitergebnisse (3)
- Lebensqualität (3)
- MPFL (3)
- Medizin (3)
- Mesenchymale Stammzelle (3)
- Operationstechnik (3)
- Osteoporosis (3)
- Osteosynthese (3)
- Parathormon (3)
- Patella (3)
- Patellaluxation (3)
- Plasmozytom (3)
- Schmerz (3)
- Stammzelle (3)
- THA (3)
- Therapieerfolg (3)
- ankle (3)
- autograft (3)
- back pain (3)
- breast cancer (3)
- cartilage regeneration (3)
- clinical study (3)
- foot (3)
- in vitro (3)
- injury (3)
- knee replacement (3)
- mesenchymal stromal cells (3)
- mineralization (3)
- modular (3)
- muscle (3)
- osteogene Differenzierung (3)
- osteogenesis (3)
- patellar tendon (3)
- periprothetische Infektion (3)
- reoperation (3)
- rotator cuff (3)
- stemness (3)
- tranexamic acid (3)
- AMADEUS (2)
- Abrieb (2)
- Aequos G1 (2)
- Aktivität (2)
- Akupunktur (2)
- Alkalische Phosphatase (2)
- Altern (2)
- Aseptische Lockerung (2)
- Bewegungsapparat (2)
- Bisphosphonates (2)
- Bone marrow (2)
- CCN1 (2)
- COVID-19 (2)
- CRISPR/Cas-Methode (2)
- CYP24A1 (2)
- Cartilage regeneration (2)
- Chondrogenese (2)
- Constant Score (2)
- Constant score (2)
- Constant-Score (2)
- Deformität (2)
- Diagnostik (2)
- Dämpfung (2)
- Dämpfungseigenschaften (2)
- EBRA (2)
- Endothel (2)
- Entwicklung (2)
- Finite Elemente (2)
- Fraktur (2)
- Funktion (2)
- Genexpression (2)
- Genregulation (2)
- Gentherapie (2)
- Germany (2)
- HPP (2)
- Hallux (2)
- Hyaliner Knorpel (2)
- Hüftendoprothese (2)
- Indian Hedgehog (2)
- Instabilität (2)
- Kapselshift (2)
- Kinderfuß (2)
- Kinderschuh (2)
- Kinematik (2)
- Knieendoprothese (2)
- Kniegelenkarthrose (2)
- Knochen (2)
- Knochendefekt (2)
- Knochendichte (2)
- Knochenmetastase (2)
- Komplikation (2)
- Korrektur (2)
- LMHFV (2)
- Laufverletzungen (2)
- MIS (2)
- Mechanorezeptor (2)
- Mechanotransduktion (2)
- Mesenchymal Stem Cells (2)
- Mesenchymal stem cells (2)
- Mesenchymale Stromazellen (2)
- Microarray (2)
- Migrationsanalyse (2)
- Minimal-invasive Chirurgie (2)
- Multiple myeloma (2)
- Muskelatrophie (2)
- Oberflächenersatz (2)
- Operation (2)
- Osteochondrosis dissecans (2)
- Osteogene Differenzierung (2)
- Osteotomie (2)
- PROM (2)
- Patellarsehne (2)
- Polymorphismus (2)
- Prothesenlockerung (2)
- Prothetik (2)
- Prävention (2)
- RT-PCR (2)
- Regenerative Medizin (2)
- Rekonstruktion (2)
- Resistance training (2)
- Rotatorenmanschettenruptur (2)
- SMFA-D (2)
- SOX9 (2)
- Sarcopenia (2)
- Sarkopenie (2)
- Schmerztherapie (2)
- Selenoproteine (2)
- Skiverletzung (2)
- Sonographie (2)
- Spacer (2)
- Spinal Orthosis (2)
- TKA (2)
- Tissue engineering (2)
- Total hip arthroplasty (2)
- Total knee arthroplasty (2)
- Vibrationstraining (2)
- Vitamin D (2)
- Vitamin D3 (2)
- Whole Body Vibration (2)
- XLH (2)
- Zellkultur (2)
- Zytokine (2)
- adipocytes (2)
- alkaline phosphatase (2)
- anterior approach (2)
- anteriorer Zugang (2)
- apoptosis (2)
- arthritis (2)
- aseptic loosening (2)
- biomechanics (2)
- bone defect (2)
- bone marrow (2)
- bone marrow stromal cells (2)
- bone metastases (2)
- bone metastasis (2)
- bone-mineral density (2)
- calipered (2)
- cement (2)
- collagen (2)
- complications (2)
- cushion (2)
- cushioning (2)
- development (2)
- direct anterior approach (2)
- endothelial progenitor cells (2)
- enzyme replacement therapy (2)
- epidemiology (2)
- exercise (2)
- follow-up (2)
- fracture healing (2)
- health-related quality of life (2)
- hip arthroplasty (2)
- hip fracture (2)
- iTotal (2)
- imaging (2)
- immunomodulation (2)
- implant positioning (2)
- in-vitro (2)
- joint aspiration (2)
- knee joint (2)
- knee osteoarthritis (2)
- men (2)
- metabolism (2)
- migration analysis (2)
- minimal-invasiv (2)
- model (2)
- morphogenetic protein (2)
- musculoskeletal system (2)
- myeloma (2)
- myokines (2)
- nervous system (2)
- oestrogen receptor signalling (2)
- orthesis (2)
- orthopaedics (2)
- orthopedics (2)
- os akromiale (2)
- osteogenic potential (2)
- oxidative stress (2)
- pain (2)
- patient-specific (2)
- periprosthetic joint infection (2)
- physical performance (2)
- postoperative Komplikationen (2)
- postoperative pain (2)
- prevention (2)
- prospective (2)
- prospective study (2)
- prosthesis (2)
- prothesis (2)
- replacement (2)
- revision arthroplasty (2)
- rheumatoid arthritis (2)
- roentgenographic assessment (2)
- rotation (2)
- running injuries (2)
- scaffolds (2)
- semitendinosus (2)
- senescence (2)
- septic (2)
- shoulder arthroplasty (2)
- shoulder pain (2)
- spherical pressfit cup (2)
- sphärische Pressfit-Pfanne (2)
- stromal cells (2)
- surgery (2)
- teriparatide (2)
- tissue (2)
- total joint arthroplasty (2)
- training (2)
- two-stage exchange (2)
- untranslated exons (2)
- untranslatierte Exons (2)
- Östrogene (2)
- Östrogenrezeptor (2)
- .................................................................... (1)
- 2',7'-dichlorofluorescin (1)
- 24-Hydroxylase Promotoranalyse (1)
- 3D analysis (1)
- 3D models (1)
- 3D organoids (1)
- 3D printing (1)
- 3D-Bildanalyse (1)
- 3D-Zellkultur (1)
- 9-cis-Retinsäure (1)
- AC-Stabilisierung (1)
- ACL-Reconstruction (1)
- ACL-Rekonstruktion (1)
- ADAMTS (1)
- ADO II (1)
- ALPL (1)
- AMIS (1)
- AMIS, Direct anterior approach, hip arthroplasty, stepwatch, comparison (1)
- ANGPTL_4 (1)
- AORI-Klassifikation (1)
- Acetabular (1)
- Achilles (1)
- Acromioclavicular Joint (1)
- Acromioclavicular joint dislocation (1)
- Acromioclaviculargelenkssprengung (1)
- Activity (1)
- Acute osteomyelitis (1)
- Adenoviraler Gentransfer (1)
- Adenoviren (1)
- Adenovirus (1)
- Adhärenz (1)
- Adipogenesis (1)
- Adipozyten (1)
- Aequalis (1)
- Aggrekan (1)
- Aktivitätsmarker (1)
- Albers-Schönberg disease (1)
- Alter (1)
- Alterstraumatologie (1)
- Alterung (1)
- Aminopeptidase (1)
- Analgesie (1)
- Anatomic reattachment (1)
- Angiogenese (1)
- Angiopoetin (1)
- Angiopoietin-like 4 (1)
- Animal model (1)
- Anpassung (1)
- Anterior cruciate ligament (1)
- Antigen CD14 (1)
- Antioxidantien (1)
- Anämie (1)
- Apoptose (1)
- Apoptosis (1)
- Array (1)
- Arthose (1)
- Arthroplastik (1)
- Arthroscopy (1)
- Arthrotomie (1)
- Arzneimittelforschung (1)
- Aseptic loosening (1)
- Asymmetrische Pfannenkomponente (1)
- Autologe Chondrozytentransplantation (1)
- Autologous Chondrocyte Transplantation (1)
- BMSC (1)
- Bakterielle Infektion (1)
- Bandage (1)
- Bankart Läsion (1)
- Basketball (1)
- Bauer (1)
- Beckenchirurgie (1)
- Beckendiskontinuität (1)
- Beckenkammtransfer (1)
- Beidbeinsprung (1)
- Benzoporphyrinderivat (1)
- Beru (1)
- Berufskrankheit (1)
- Betriebsmedizin (1)
- Biofabrication (1)
- Biofilm (1)
- Bioreaktor (1)
- Bisphosphonate (1)
- Bizepssehne (1)
- Bluttransfusion (1)
- Bone Mineral Density (1)
- Bone disease (1)
- Bone marrow stromal cell (BMSC) (1)
- Bone morphogenetic protein-2 (1)
- Bone tumor (1)
- Bortezomib (1)
- Brandes (1)
- Breast cancer cells (1)
- Brustkrebs (1)
- CA-Repeat Polymorphismen (1)
- CCN (1)
- CCN Protein Familie (1)
- CCN protein familiy (1)
- CCN- Proteine (1)
- CCN-proteins (1)
- CHAQ (1)
- CLCN7 (1)
- CRISPR/Cas9 (1)
- CT (1)
- CXCR4 (1)
- CYP24 (1)
- Cartilage (1)
- Carving (1)
- Carving-Ski (1)
- Carving-Verletzung (1)
- Carving-injuries (1)
- Case report (1)
- Caspase 3/7 activity (1)
- Cell viability, (1)
- Cellculture (1)
- Ch'i-kung (1)
- Chemokin CXCL12 (1)
- Chemotherapie (1)
- Children`s shoe (1)
- Chirodiagnostik (1)
- Chondrogene Differenzierung (1)
- Chondrogenesis (1)
- Chondrogenic Differentiation (1)
- Chondroplastik (1)
- Chondrosarcoma (1)
- Chondrozytentransplantation (1)
- Clavicula (1)
- Clawtoe (1)
- Clc-7 (1)
- Clodronat (1)
- Clodronate (1)
- Clubfoot (1)
- Collagen (1)
- Collagen Hydrogel (1)
- Comparison of Analgesia (1)
- Copal\(^®\) spacem (1)
- Copeland (1)
- Coxarthrose (1)
- Cyclisches Nucleotid Phosphodiesterase <3,5-> (1)
- Cystein-rich-protein 61 (CYR61) (1)
- Cytokine (1)
- DAA (1)
- DGOU (1)
- Datenbank (1)
- Decorine (1)
- Deformity (1)
- Dendritische Zellen (1)
- Depression (1)
- Depressivität (1)
- Desmoplastic fibroma (1)
- Deutschland (1)
- Deutschland / Bundeswehr (1)
- Differentiation (1)
- Direct anterior approach (1)
- Distal biceps tendon repair (1)
- Doppler-Sonographie (1)
- Druckverteilung (1)
- Dysplasie (1)
- Dämpfungsmechanismen (1)
- Débridement (1)
- EBRA-FCA (1)
- ECM remodeling (1)
- EQ-5D (1)
- ER signaling (1)
- ER-Alpha Expression (1)
- ERAS (1)
- Early Onset Schulterarthrose (1)
- Effektstärken (1)
- Eingriff (1)
- Eisenoxidpartikel (1)
- Elderly patients (1)
- Electrospinning (1)
- Ellenbogen (1)
- Eltern (1)
- Endothelial growth-factor (1)
- EnduRo (1)
- Entzündung (1)
- Entzündungsparameter (1)
- Epidemiological analysis (1)
- Epidemiologie (1)
- Epiphyseodese (1)
- Extrazelluläre Matrix (1)
- FFbH-OH (1)
- FGF23 (1)
- Fahrradergometer (1)
- Failure (1)
- Fast-track-program (1)
- Fehlerverhütung (1)
- Fehlstellung (1)
- Femoraler Offset (1)
- Fettzelle (1)
- FiberTape (1)
- Fibrin (1)
- Fibroblastenwachstumsfaktor (1)
- Fixateur interne (1)
- Fliegendes Personal (1)
- Fliegerarzt (1)
- Fragebogen (1)
- Frakturheilung (1)
- Frühmobilisierung (1)
- Funktionsfragebogen Bewegungsapparat (SMFA-D) (1)
- Fußdeformität (1)
- Fußskelett (1)
- GDF-5 (1)
- GH (1)
- Galectin 1 (1)
- Galectine (1)
- Ganzkörpervibrationstraining (1)
- Gelenkendoprothese (1)
- Gelenkinfektion (1)
- Gelenkknorpelrekonstruktion (1)
- Gelenkpfanne (1)
- Gen Transfer (1)
- Gene expression profiling (1)
- Gene therapy (1)
- Genetics (1)
- Genom (1)
- Gentherpie (1)
- Geschlechtshormone (1)
- Glenohumerales Gelenk (1)
- Glenohumeralgelenk (1)
- Glenoidrandfraktur (1)
- Glutathionperoxidase (1)
- Glycocalyx (1)
- Glykobiologie (1)
- Glykokalyx (1)
- Grosszeh (1)
- Großzehe (1)
- HHS (1)
- HIP osteoarthritis (1)
- Haematogenous (1)
- Hallux valgus (1)
- Handchirurgie (1)
- Handdeformität (1)
- Handgelenk (1)
- Handgelenkserkrankungen (1)
- Harris Galante Pfanne (1)
- Harris Hip Score (1)
- Harris-Galante (1)
- Harris-Galante-Pfannen (1)
- Heeresfliegertruppe (1)
- Heterotope Ossifikation (1)
- Heterotope Ossifikationen (1)
- Heterotopic ossifikation (1)
- High Tibial Osteotomy (1)
- Hip Arthroplasty (1)
- Hip arthroplasty (1)
- Hip joint (1)
- Hip resurfacing (1)
- Histologie (1)
- Histology (1)
- Hormonveränderung (1)
- Hubschrauber (1)
- Hubschrauberpilot (1)
- Hueter interval (1)
- Humerusfraktur (1)
- Humeruskopfnekrose (1)
- Hydroxylapatit (1)
- Hypertrophy (1)
- Hypophosphatemia (1)
- Hüft Prothese (1)
- Hüft-TEP (1)
- Hüft-TEP-Implantation (1)
- Hüftdysplasie (1)
- Hüftendoprothesenwechseloperationen (1)
- Hüftgelenkarthrose (1)
- Hüftgelenkentzündung (1)
- Hüftgelenkersatz (1)
- Hüftgelenksersatz (1)
- Hüftgelenksprothese (1)
- Hüftkopfnekrose (1)
- Hüftpfanne (1)
- Hüfttotalendoprothese (1)
- Hüfttotalendoprothetik (1)
- ICM (1)
- ICRS (1)
- IDSA (1)
- IGF-1 (1)
- IL-1 α und β (1)
- IL-1β (1)
- IL1RA (1)
- ISIS (1)
- Ideberg (1)
- Immunmodulation (1)
- Immunodeficiency (1)
- Impingement-Syndrom (1)
- Implant (1)
- Implantation (1)
- Indian hedgehog (1)
- Indikationen für Prothesenwechsel (1)
- Infektion (1)
- Infektionsprophylaxe (1)
- Infektpersistenz (1)
- Interleukin (1)
- Interleukin-1 (1)
- Intermetatarsalwinkel (1)
- Isokinetik (1)
- Joint capsule (1)
- KINDL (1)
- KOOS (1)
- Kapandji pinning (1)
- Kapandjidrahtosteosynthese (1)
- Keller (1)
- Keramik (1)
- Keramikkopf (1)
- Kernspintomografie (1)
- Kind (1)
- Kinderorthopädie (1)
- Kirschner-Draht (1)
- Kleinzehendeformitäten (1)
- Klinische Studie (1)
- Klinisches Experiment (1)
- Klonierung (1)
- Klotho (1)
- Klumpfuß (1)
- Knee Endo Prostheses (1)
- Knee Osteoarthritis (1)
- Knee prosthesis (1)
- Knee replacement (1)
- Knee-injuries (1)
- Knie Endo Prothese (1)
- Knieendoprothetik (1)
- Kniegelenksendoprothese (1)
- Kniescheibe (1)
- Kniescheibenverrenkung (1)
- Knieschmerzen (1)
- Knieverletzung (1)
- Knievrevision (1)
- Knochen-Morphogenese-Proteine (1)
- Knochenbildung (1)
- Knochenersatz (1)
- Knochenheilung (1)
- Knochenmarker (1)
- Knochenmetastasen (1)
- Knochensialoprotein (1)
- Knochenstoffwechsel (1)
- Knochentumor (1)
- Knochenumbau (1)
- Knorpelchirurgie (1)
- Knorpeldegeneration (1)
- Knorpelrekonstruktion (1)
- Knorpelstoffwechsel (1)
- Knöcherne Fixation (1)
- Kollagen Hydrogel (1)
- Kollagen I-Hydrogel (1)
- Kollagen I-Scaffold zum Sehnenersatz (1)
- Kollagen I-Scaffolds (1)
- Kollagen Typ II (1)
- Kollagen-Hydrogel (1)
- Kollagenasen (1)
- Kollagengel (1)
- Komfort (1)
- Komplikationen (1)
- Komplikationsrate (1)
- Konsensus-Klassfikation (1)
- Konstrukt (1)
- Kontrollierte klinische Studie (1)
- Korakoklavikuläre Bänder (1)
- Korrelation (1)
- Koxarthrose (1)
- Kraft (1)
- Krafttraining (1)
- Kraftverhalten Oberschenkelmuskulatur (1)
- Krallenzehendeformität (1)
- Kranialpfanne (1)
- Kreuzschmerz (1)
- Körpergewicht im Verhältnis zu zementierter Schaftoberfläche (1)
- Körperliche Leistungsfähigkeit (1)
- LBS-Tenodese (1)
- LCP (1)
- LCS (1)
- LCS knee system (1)
- LRP (1)
- Laborparameter (1)
- Laminektomie (1)
- Laminotomie (1)
- Langzeit (1)
- Langzeitstudie (1)
- Lastwechsel (1)
- Laufschuhe (1)
- Laufsport (1)
- Laufvorgang (1)
- Lesser toe (1)
- Ligamentum acromioclaviculare (1)
- Ligamentum capitis femoris (1)
- Link Endo-Model (1)
- Long bones (1)
- Low Dose Tranexamic acid (1)
- Lower extremity reconstruction (1)
- Luxationsfraktur (1)
- M. Ahlbäck (1)
- M. Albers-Schönberg (1)
- MLO-A5 (1)
- MLO-Y4 (1)
- MMP-3 (1)
- MPFL Ersatz (1)
- MPFL reconstruction (1)
- MPFL-Ersatz (1)
- MPFL-Plastik (1)
- MPFL-Rekonstruktion (1)
- MR neurography (1)
- MRI (1)
- MRP-Revisionsschaft (1)
- MRT (1)
- MSIS (1)
- MSZ (1)
- Madelung (1)
- Madelung deformity (1)
- Madelung's deformity (1)
- Madelung, Otto Wilhelm (1)
- Madelung-Deformität (1)
- Mammakarzinom (1)
- Marathon (1)
- Mechanical strain (1)
- Mechanische Beinachse (1)
- Meissner Korpuskel (1)
- Meniskus (1)
- Merete (1)
- Mesenchymal stem cell (1)
- Mesenchymal stem/stromal cells (1)
- Mesenchymale (1)
- Mesenchymale Stromazelle (1)
- Metabolic Glycoengineering (1)
- Metaplasie (1)
- Metastase (1)
- Metatarsalgie (1)
- Meves compression plate (1)
- Meves-Kompressionsplatte (1)
- Mikrosatelliteninstabilität (1)
- Mineralisation (1)
- Mini-Open (1)
- Minimalinvasiv (1)
- Minimalinvasiver vorderer Zugang (1)
- Mittelfußknochen (1)
- Modell (1)
- Modular (1)
- Molekularbiologie (1)
- Molekulargenetik (1)
- Monoklonale Gammopathie (1)
- Monozyt (1)
- Morawietz (1)
- Multilpes Myelom (1)
- Multiples Myelom (1)
- Muscle (1)
- Musculus biceps brachii (1)
- Musculus latissimus dorsi (1)
- Muskel (1)
- Muskelgewebe (1)
- Muskeltransposition (1)
- Muskuloskelettal (1)
- Myokine (1)
- Männer (1)
- NMR-Bildgebung (1)
- NMR-Tomographie (1)
- NSAID (1)
- NSAR (1)
- Nachbehandlung (1)
- Nervenendigung (1)
- Nervus suprascapularis (1)
- Nichtsteroidales Antiphlogistikum (1)
- Niedrig dosierte Tranexamsäure (1)
- Niereninsuffizienz (1)
- Nigeria (1)
- Non-simultaneous bilateral distal biceps tendon rupture (1)
- Nonresorbable suture tape (1)
- Novobiocin (1)
- OPLA (1)
- Oberschenkelbruch (1)
- Occupational disease (1)
- Odonto-HPP (1)
- Offset (1)
- Operationsverfahren (1)
- Optimierung (1)
- Orthese (1)
- Os akromiale (1)
- Oscillating bone-saw (1)
- Oseolysis (1)
- Osseuous fixation (1)
- Osteoarthrose (1)
- Osteoblast (1)
- Osteoblasten (1)
- Osteogenese (1)
- Osteogenesis (1)
- Osteogenic precursor cells (1)
- Osteoklast (1)
- Osteolyse (1)
- Osteolysen (1)
- Osteomyelitis of the humerus (1)
- Osteoporose Serumparameter (1)
- Osteotomies around the knee joint with plate fixation (1)
- Osteotomy (1)
- Osteozyt (1)
- Oszillierende Knochensägen (1)
- Oxford Shoulder Instability Score (1)
- Oxford knee score (1)
- Oxidativer Stress (1)
- PA-flexed view (1)
- PCL retention (1)
- PE-UHMW (1)
- PEEK (1)
- PIP- Arthrodese (1)
- PIP- Arthrodesis (1)
- PMMA (1)
- PMMA bone cement (1)
- PPD (1)
- PTH (1)
- PTH/PTHrP receptor (1)
- PTH/PTHrP-Rezeptor (1)
- PVP-Iod (1)
- Pacini Korpuskel (1)
- Painless clinic (1)
- Papaverin (1)
- Paprosky (1)
- Paracetamol (1)
- Parecoxib (1)
- Patellainstabilität (1)
- Patellar instability (1)
- Patellarsehnentransplantat (1)
- Patellofemorale Instabilität (1)
- Patientenaktivität (1)
- Patientenbefindlichkeit (1)
- Pedicled perforator flap (1)
- Periprostethic loosening (1)
- Periprothetisch (1)
- Periprothetische Zyste (1)
- Periprothetischer Lysesaum (1)
- Peritalare Arthrolyse (1)
- Pfannendachplastik (1)
- Phosphat (1)
- Phosphodiesterase 10A (1)
- Photodynamic therapy (1)
- Photodynamische Therapie (1)
- Physiolyse (1)
- Phytopharmakon (1)
- Plastische Chirurgie (1)
- Polyarthritis (1)
- Polycaprolacton (1)
- Polyethelen (1)
- Polyethylen (1)
- Polyethylenabrieb (1)
- Polylaktid (1)
- Polymerase Kettenreaktion (1)
- Polymerase-Kettenreaktion (1)
- Polymerase-Kettenrektion (1)
- Polymorphism (1)
- Polymorphismen (1)
- Polymorphismen MMP-3 (1)
- Porcin (1)
- Postoperative Schmerztherapie (1)
- Postoperative pain therapy (1)
- Postoperativer Schmerz (1)
- Postoperatives Offset (1)
- Posturale Stabilität (1)
- Povidon-Iod (1)
- Povidoneiodine (1)
- Power Doppler (1)
- Power Doppler Sonography (1)
- Powerdoppler (1)
- Press-fit (1)
- Primary hip arthroplasty (1)
- Primäre Hüftprothese (1)
- Probenecid (1)
- Proliferation (1)
- Promotor (1)
- Pronation (1)
- Propeller flap (1)
- Prophylaxe (1)
- Prospective Study (1)
- Proteoglykane (1)
- Proximaler Humerus (1)
- Pseudarthrose (1)
- Puromycin (1)
- Pycnogenol (1)
- Q-CT (1)
- Qi Gong (1)
- Qi gong (1)
- Quality management (1)
- Qualitätsmanagement (1)
- R57A (1)
- RNAi (1)
- RNS-Spleißen (1)
- Rachitis (1)
- Radiatio (1)
- Radiation (1)
- Radiographs (1)
- Radiuskorrekturosteotomie (1)
- Reason for revision (1)
- Recurrence (1)
- Register (1)
- Rehabilitationseinrichtung (1)
- Reliability (1)
- Reliabilität (1)
- Reoperation (1)
- Reposition (1)
- Reruptur (1)
- Resektion (1)
- Resektionsarthroplastik (1)
- Residual clubfoot (1)
- Residuelle Deformitäten (1)
- Resurface (1)
- Retinsäure (1)
- Retrospektive Auswertung (1)
- Reverse Prosthesis (1)
- Reverse Schulterendoprothese (1)
- Reverse Transkriptase-Polymerase-Kettenreaktion (1)
- Revision in hip arthroplasty (1)
- Revisionseingriff (1)
- Revisionsgründe (1)
- Revisionsoperation (1)
- Revisionsursachen (1)
- Rezidiv (1)
- Rezidivluxationen (1)
- Rheumatoid Arthritis (1)
- Rheumatoid arthritis (1)
- Rheumatoidarthritis (1)
- Rickets (1)
- Risikofaktor (1)
- Risikofaktoren (1)
- Roll-Gleit-Mechanismus (1)
- Rotator cuff (1)
- Rotator cuff tear (1)
- Rotatorenmannschettendefekt (1)
- Rotatorenmanschettenriss (1)
- Rückenorthese (1)
- Rückenschmerz (1)
- SF-36 (1)
- SHBG (1)
- SIRT1 (1)
- SLAP-Läsion (1)
- SLAP-lesion (1)
- SNP (1)
- Scaffold (1)
- Scherstress (1)
- Schlüsselbein (1)
- Schmerzfragebogen (1)
- Schmerzfreie Klinik (1)
- Schultereckgelenk (1)
- Schultereckgelenkssprengung (1)
- Schulterendoprothesenwechsel (1)
- Schulterfunktion (1)
- Schultergelenkluxation (1)
- Schultergelenkschmerz (1)
- Schultergelenksinfektion (1)
- Schultergelenkverletzung (1)
- Schulterinstabilität (1)
- Sehne (1)
- Sehnenentzündung (1)
- Sehnenersatz (1)
- Selenmangel (1)
- Semitendinosussehne (1)
- Semitendinosussehnem Autograft (1)
- Semitendinosussehnentransplantat (1)
- Serum inducibility of hCYR61/CCN1 promotor activity (1)
- Seruminduktion des hCYR61/CCN1 Promotors (1)
- Shear Stress (1)
- Shoulder (1)
- Ski-injuries (1)
- Skiunfall (1)
- Soft-tissue sarcoma (1)
- Sohlenflexibilität (1)
- Sonography (1)
- Spine (1)
- Splicing (1)
- Spontane Osteonekrose (1)
- Sportart (1)
- Sportliche Bewegung (1)
- Sportschuhe (1)
- Sportverletzungen (1)
- Sprunganalyse (1)
- Sprunggelenkverletzung (1)
- Sprungleistung (1)
- Spunggelenkendoprothetik (1)
- Stabilität (1)
- Stammzelltransplantation (1)
- Standardisierte Schmerztherapie (1)
- Standardized pain therapy (1)
- Staphylococcus aureus / drug effects (1)
- Staphylokokken (1)
- Stemness (1)
- StepWatch (1)
- Stepwatch (1)
- Stimulation (1)
- Stimulationsversuche (1)
- Super-side-cut-ski (1)
- Suprascapular nerve (1)
- Suture anchor (1)
- Synovectomy (1)
- Synovektomie (1)
- Synovia (1)
- Synovial Fluid Aspiration (1)
- Synovialitis (1)
- Synthetischer Bandersatz (1)
- Synthetisches Bandersatzmaterial (1)
- Systematischer Review (1)
- TCM (1)
- TEP (1)
- TNF α (1)
- TNF-alpha (1)
- Temporäre Hemiepiphyseodese (1)
- Tenodesis of the long head of the biceps tendon (1)
- Testosteron Östrogene (1)
- Therapieergebnisse (1)
- Thioredoxin (1)
- Thioredoxin Reduktase (1)
- Thioredoxin reductase (1)
- Tibia (1)
- Tiermodell (1)
- Titan (1)
- TomoFix (1)
- Topoisomerase I (1)
- Torsion (1)
- Total Hip Arthroplasty (1)
- Total Knee Arthroplasty (1)
- Trabekuläre Mesenchymale Stammzelle (1)
- Tranexamsäure (1)
- Transdifferenzierung (1)
- Transfusionsrate (1)
- Transgene Mäuse (1)
- Transgluteal approach (1)
- Transglutealer Zugang (1)
- Transporthubschrauberregiment 30 (1)
- Traubensilberkerze (1)
- Trauma (1)
- Tribologie (1)
- Triple Pelvic Osteotomy (1)
- Tumor (1)
- Tumorinstability (1)
- Tumorinstabilität (1)
- Tumorähnliche Läsion (1)
- Tönnis (1)
- Ulnakopfprothese (1)
- Ultraschalldiagnostik (1)
- VDR (1)
- VSOP (1)
- Valgus osteoarthritis (1)
- Validität (1)
- Vancomycin / administration & dosage (1)
- Vancomycin / chemistry (1)
- Vancomycin / pharmacology (1)
- Vaskularisation (1)
- Vaskulogenese (1)
- Vergleichsstudie (1)
- Verlauf (1)
- Verrenkung (1)
- Versagen (1)
- Versagensgründe (1)
- Verumgruppe (1)
- Vickers-Band (1)
- Viergelenk (1)
- View (1)
- Visual analogue scale (1)
- Visuelle Analogskala (1)
- Vitamin D metabolism (1)
- Vitamin D metabolismus (1)
- Vitamin D-Rezeptor (1)
- Vitamin-D-Mangel (1)
- Vorfuß (1)
- WBC (1)
- WISP-3 (1)
- WISP1/CCN4 (1)
- WISP3 (1)
- WNT pathway (1)
- WNT signaling pathway (1)
- WNT5A (1)
- WOMAC (1)
- Wachstumsfaktor (1)
- Wachstumsfaktoren (1)
- Wear (1)
- Weaver-Dunn (1)
- Werk (1)
- Wirbelsäule (1)
- Wnt (1)
- Wnt signalling (1)
- Wnt-signalling (1)
- Wnt/β-catenin signaling (1)
- Wundspülung (1)
- Wundversorgung (1)
- XSMFA-D (1)
- Zell-basierte Therapie (1)
- Zellmarkierung (1)
- Zugangswege (1)
- Zwischensohlenmodifikation (1)
- abrollverhalten (1)
- accelerometer (1)
- accuracy (1)
- acetabular bone defect (1)
- acetabular bone defects (1)
- acromioclavicular joint (1)
- activity (1)
- activity monitor (1)
- acupuncture (1)
- additive manufacturing (1)
- adenovirale Transduktion (1)
- adherence (1)
- adipogene Differenzierung (1)
- adipogenic differentiation (1)
- adult stem cells (1)
- age (1)
- age and gender analysis (1)
- age distribution (1)
- age-related (1)
- age-related osteoporosis (1)
- aggrecan (1)
- aging (1)
- aircrew (1)
- alendronate (1)
- algorithm (1)
- alkaline-phosphatase (1)
- all-trans-Retinsäure (1)
- allografts (1)
- alpha (1)
- alternative splicing (1)
- alternatives Splicing (1)
- altersabhängig (1)
- alumina (1)
- aminopeptidase (1)
- anatomic center of rotation (1)
- anatomical landmark (1)
- anatomy (1)
- angiogenic cytokines (1)
- anterior cruciate ligament (1)
- anterolateral (1)
- anthropometric (1)
- anthropometrie (1)
- anti-bacterial agents / administration & dosage (1)
- anti-bacterial agents / chemistry (1)
- anti-bacterial agents / pharmacology (1)
- antibiotic elution (1)
- antioxidants (1)
- antiseptics (1)
- apatite nanoparticles (1)
- approach (1)
- arthrodeses (1)
- arthrodesis (1)
- arthrography (1)
- arthroscopic simulator training (1)
- arthrosis (1)
- arthrotomy (1)
- articular cartilage repair (1)
- artifact (1)
- aseptic (1)
- aseptisch (1)
- asfotase alfa (1)
- assistive devices (1)
- asymmetric implant (1)
- athletic injuries (1)
- autologous chondrocyte implantation (1)
- autophagy (1)
- autosomal dominant osteopetrosis type II (1)
- autosomal-dominant osteopetrosis (1)
- axial alignment (1)
- bandage (1)
- basketball (1)
- benige tumor (1)
- benign bone tumor (1)
- benzoporphyrin derivative (1)
- beta-tricalciumphosphate (1)
- bi-compartmental (1)
- bi-compartmental knee arthoplasty (1)
- biceps tendinitis (1)
- biceps tendon (1)
- bicompartmental (1)
- bikondylär (1)
- biocompatible Materials (1)
- biodegradable polymers (1)
- biofilm (1)
- biomarkers Myelomas (1)
- biomaterials – cells (1)
- biomolecular processes (1)
- bioreactor (1)
- bisphenol A (1)
- bisphosphonates (1)
- black cohosh (1)
- bone QCT (1)
- bone biology (1)
- bone cement (1)
- bone colonization (1)
- bone density (1)
- bone formation (1)
- bone fractures (1)
- bone healing (1)
- bone imaging (1)
- bone loss (1)
- bone marrow edema (1)
- bone marrow lesion/edema (1)
- bone marrow mesenchymal stromal cells (BM-MSCs) (1)
- bone metabolism (1)
- bone model (1)
- bone morphogenic protein 2 (1)
- bone morphology (1)
- bone reaction (1)
- bone regeneration (1)
- bone remodeling (1)
- bone remodelling (1)
- bone sialoprotein (1)
- bone substitute (1)
- bone tissue engineering (1)
- bone tumour (1)
- bone turnover (1)
- bone wires (1)
- bony bankart (1)
- cAMP (1)
- calcaneus (1)
- calcification (1)
- calcium phosphate (1)
- cancer microenvironment (1)
- cardiovascular (1)
- cartilage defect (1)
- cartilage defects (1)
- cartilage surgery (1)
- carving ski (1)
- case report (1)
- cell death (1)
- cell labeling (1)
- cell proliferation (1)
- cell-based therapies (1)
- cell-based therapy (1)
- cell-free therapeutics (1)
- cell-matrix interaction (1)
- cells (1)
- cellular origin (1)
- cellular signalling networks (1)
- cementless (1)
- children (1)
- children´s shoe (1)
- chirotherapy (1)
- chondral defect (1)
- chondrogene Differenzierung (1)
- chondrogenic differentiation (1)
- chondrogenic hypertrophy (1)
- cisplatin resistance (1)
- clavicular nonunion (1)
- click chemistry (1)
- clinical and radiological manifestations (1)
- clinical outcome (1)
- cloning (1)
- collagen I-hydrogel (1)
- collagen gel (1)
- collagen hydrogel (1)
- collagen type II (1)
- collagenases (1)
- collarless (1)
- colony-stimulating factor (1)
- colorectal carcinogensis (1)
- comfort (1)
- community-dwelling (1)
- comparison (1)
- compression syndrome (1)
- compressive load (1)
- compressive strength (1)
- computer modelling (1)
- computer navigation (1)
- conforming (1)
- congruency (1)
- consensus (1)
- consensus classification (1)
- constent score (1)
- contact (1)
- coracohumeral distance (1)
- coracohumeral impingement (1)
- core depression (1)
- correction (1)
- correlation (1)
- craniosynostosis (1)
- cultures (1)
- curcumin (1)
- curettage (1)
- custom made implant (1)
- custom-made implant (1)
- cutibacteria (1)
- cyr61 (1)
- cytokines (1)
- database (1)
- decellularization (1)
- defects (1)
- deformity (1)
- dendritic cells (1)
- dental status (1)
- dental stem cells (1)
- dentale Stammzellen (1)
- dermal fibroblasts (1)
- dexamethasone (1)
- differentiation capacity (1)
- distal fixation (1)
- distale Radiusfraktur (1)
- distale instabile Radiusfraktur (1)
- drain (1)
- dreidimensionale Rekonstruktion (1)
- dreifache Beckenosteotomie (1)
- drug liberation (1)
- dual-room trauma suite (1)
- dynamic magnetic resonance imaging (1)
- dynamische MRT (1)
- dynamometer (1)
- dyskinesia (1)
- early stage (1)
- effect sizes (1)
- efficiency (1)
- elbow (1)
- elution (1)
- endochondral ossification (1)
- endocrine disruption (1)
- endoprosthetics (1)
- endoprothesis (1)
- endotheliale Vorläuferzellen (1)
- engineering (1)
- entrapment, traction (1)
- epidemiological analysis (1)
- epidermal growth factor (1)
- epithelial-mesenchymal transition (1)
- estrogen (1)
- estrogen receptor (1)
- estrogen receptor beta (1)
- etiology (1)
- exosomes (1)
- expression (1)
- extracellular vesicles (EVs) (1)
- failed hemiarthroplasty (1)
- failure (1)
- failure load (1)
- fast track rehabilitation (1)
- fast-track-concepts (1)
- femoral head (1)
- femoral head bone graft (1)
- femoral revision (1)
- femur (1)
- fibrin (1)
- finite element (1)
- fixation (1)
- flexibility (1)
- flexion (1)
- fluid simulation (1)
- fluorescence microscopy (1)
- fluorescent dyes (1)
- foamy virus (1)
- foot and ankle procedures (1)
- force (1)
- force behavior (1)
- forefoot (1)
- forgotten joint score (1)
- fracture analysis (1)
- fracture incidence (1)
- fracture risk (1)
- fractures (1)
- fragility fractures (1)
- frauenschuhe (1)
- functional characterization of promotor CA-repeat polymorphism activity (1)
- functionality outcome (1)
- gait (1)
- gene (1)
- gene constructs (1)
- gene therapy (1)
- gene transfer (1)
- gene-expression (1)
- genetherapy (1)
- genetics (1)
- genom (1)
- gentamicin-loaded poly (methyl methacrylate) bone cement (1)
- geometry (1)
- germanophone (1)
- geschlossene präoperative Reposition (1)
- glenohumeral joint (1)
- glenoid rim (1)
- glutathionperoxidase (1)
- glycocalyx (1)
- grading system of chondral defects (1)
- growth factor (1)
- growth factors (1)
- gyroscope (1)
- hCYR61 (1)
- hCYR61/CCN1 Promotoranalyse (1)
- hCYR61/CCN1 promotor (1)
- hCyr61/CCN1 (1)
- hFOB (1)
- hMSC (1)
- hMSC-TERT (1)
- hMSCs (1)
- haematological cancer (1)
- haemoglobin (1)
- hallux (1)
- hand dominance (1)
- handball (1)
- head and neck squamous cell carcinoma (1)
- helicopter (1)
- hematoma (1)
- high bone mass (1)
- high tibial osteotomy (1)
- high tibial valgus osteotomy (1)
- high-bone-mass (1)
- hintere Schulterluxation (1)
- hip athroplasty (1)
- hip dysplasia (1)
- hip joint (1)
- hip replacement (1)
- homeostasis (1)
- hormon (1)
- human atherosclerotic lesions (1)
- human mesenchymal stem cell (1)
- human mesenchymal stem cells (1)
- human movement (1)
- human prostate-cancer (1)
- human sole of foot (1)
- human trabecular bone decellularization (1)
- humane mesenchymale Stammzellen (1)
- humane mesenchymle Stammzellen (1)
- humanized bone models (1)
- humanized xenograft model (1)
- hydrogel (1)
- hydrogels (1)
- hydroxyapatite (1)
- hypovitaminosis D (1)
- iMP (1)
- iliac crest (1)
- iliac crest transfer (1)
- immunotherapy (1)
- impact (1)
- impaction bone grafting (1)
- implant design (1)
- implant fit (1)
- implant survival (1)
- in situ guided tissue regeneration (1)
- in situ hybridization (1)
- in vitro modeling (1)
- in vitro models (1)
- in vivo (1)
- in-vivo (1)
- inbound medical tourism (1)
- indian hedgehoc (1)
- individualisierte Prothese (1)
- infected hip endoprothesis (1)
- infection prophylaxis (1)
- infection-persistence (1)
- inflammatory gene (1)
- infliximab (1)
- injury prevention (1)
- inpatient rehabilitation (1)
- insert (1)
- insertion (1)
- interleukin (1)
- interleukin 1 receptor antagonist (1)
- intermetatarsalangle (1)
- interstage aspiration (1)
- intraoperativ (1)
- intraoperative (1)
- inverse Prothese (1)
- inverse Schulter-TEP (1)
- inverse Schulterprothese (1)
- isokinetics (1)
- joint infection (1)
- junction (1)
- kanülierte Titanschraube (1)
- kinematic analysis (1)
- kinematics (1)
- knee alignment (1)
- knee axis (1)
- knee rotator cuff (1)
- knee society score (1)
- kolorektale Karzinogenese (1)
- kontrakte Kleinzehen (1)
- kontrolliert randomisierte Studie (1)
- körperbehinderte Kinder (1)
- körperliche Aktivität (1)
- laminectomy (1)
- laminotomy (1)
- lateral clavicle resection (1)
- lateral process of the talus (1)
- lateral trochlear undercoverage (1)
- lateraler Zugang (1)
- latissimus dorsi muscle (1)
- laufschuh (1)
- learning curve (1)
- leucocyte count (1)
- level mechanical vibrations (1)
- level of evidence III (1)
- linear regression (1)
- linear wear (1)
- lines (1)
- long head of biceps tendon (1)
- long term outcome (1)
- low back pain (1)
- lower extremity (1)
- lower extremity amputation (1)
- luxation fracture (1)
- magnesium (1)
- major amputation (1)
- malignancy (1)
- malnourishment (1)
- manuelle Diagnostik (1)
- marathon (1)
- maritime pine bark extract (1)
- marrow stromal cells (1)
- match load (1)
- materials testing (1)
- mayo stem (1)
- measurement (1)
- mechanical alignment (1)
- mechanical property (1)
- mechanical stimulation (1)
- mechanical torque measurement (1)
- mechanische Stimulation (1)
- mechanism (1)
- mechanoreceptor (1)
- mechanoresponsive Elemente (1)
- mechanoresponsive elements (1)
- mechanosensing (1)
- mechanosensitive reporter (1)
- medial patellofemoral ligament (1)
- medial pivot (1)
- medial stabilized (1)
- medical collateral ligament (1)
- meissner corpuscle (1)
- melt electrospinning (1)
- meniscus (1)
- menschliche Fußsohle (1)
- mesenchymal cells (1)
- mesenchymal stem-cells (1)
- mesenchymal stromal cell (1)
- mesenchymal tissues (1)
- mesenchymale Stammzelle (1)
- metaanalysis (1)
- metabolic glycoengineering (1)
- metabolic risk (1)
- metabolic syndrome (1)
- metatarsal lenght (1)
- metatarsalgia (1)
- micro-CT (1)
- micro-computed tomography (1)
- micro-traumatic (1)
- microarray (1)
- microbiological culture (1)
- microenvironment (1)
- microsatellit-instability (1)
- microstructures (1)
- midsole modifications (1)
- military (1)
- mineraliztion (1)
- minimal invasive anterior approach (1)
- minimal invasive surgery (1)
- minimal invasiver anteriorer Zugangsweg (1)
- minimalinvasive (1)
- minimally invasiv (1)
- minimally invasive (1)
- minimally invasive anterior approach (1)
- minimally invasive surgery (1)
- minimally invasive total hip arthroplasty (1)
- minimally-invasive (1)
- minor amputation (1)
- mittelfristige Ergebnisse (1)
- modified monosaccharides (1)
- molecular biology (1)
- monoclonial gammopathy (1)
- motion control (1)
- mouse model (1)
- movable sliding gantry (1)
- mtp1 (1)
- multicomponent stretching (1)
- multimodal pain management (1)
- multiple myeloma Lesions (1)
- multistrand semitendinosus tendon (1)
- muscle injury (1)
- muscle strength (1)
- muscle transposition (1)
- musculoskeletal diseases (1)
- musculoskeletal sarcoma (1)
- muskuloskelettales System (1)
- mutant mice (1)
- mutations (1)
- myeloma cells (1)
- nanostructures (1)
- nerve compression (1)
- neurolysis (1)
- neuromuskuläres Assesment (1)
- neuronal (1)
- neuropathy (1)
- neurotransmission (1)
- niche (1)
- non-contact´ (1)
- nonspecific alkaline-phosphae (1)
- nutritional status (1)
- oberes Sprunggelenk (1)
- obesity (1)
- older people (1)
- open surgical repair (1)
- operative Behandlung (1)
- operative treatment (1)
- optimization (1)
- orthopaedic surgery (1)
- orthopedic joint prosthesis (1)
- orthopedic surgery (1)
- orthopädische Implantate (1)
- os (1)
- os acromiale (1)
- osteoarthrosis (1)
- osteoblast (1)
- osteoblastic cells (1)
- osteoblasts (1)
- osteochondral allografts (1)
- osteochondritis (1)
- osteochondrosis dissecans (1)
- osteoclast (1)
- osteoclasts (1)
- osteocytes (1)
- osteogenes Potential (1)
- osteogenesis imperfecta (1)
- osteogenetic differentiation (1)
- osteokines adaptation (1)
- osteomalacia (1)
- osteonecrosis of the femoral head (1)
- osteopenia (1)
- osteoprogenitor cells (1)
- osteoprosis (1)
- osteosynthesis (1)
- osteotomy (1)
- osteotropism (1)
- outcome (1)
- ovariectomized rats (1)
- ovariectomy (1)
- overview (1)
- oxygen tension (1)
- pacini-like corpuscle (1)
- pain assessment (1)
- pain generator (1)
- pandemic (1)
- parathyroid hormone (1)
- parathyroid-hormone (1)
- parents (1)
- partial knee arthroplasty (1)
- patella alta (1)
- patella dislocation (1)
- patella instability (1)
- patellofemoral relationship (1)
- patient activity (1)
- patient blood management (1)
- patient reported outcome measures (1)
- patient specific implant (1)
- patient-specific implant (1)
- patient-specific instruments (1)
- patient-specific knee arthroplasty (1)
- pediatric surgery (1)
- pellet culture (1)
- pelvic discontinuity (1)
- people (1)
- perception (1)
- perforator (1)
- perfusion bioreactor (1)
- pericytes (1)
- periodontal disease (1)
- perioperative management (1)
- peripheral nerve (1)
- peripheral-blood (1)
- periprosthetic osteolysis (1)
- persistence (1)
- personalised orthopaedic implantation (1)
- perspectives (1)
- phosphate (1)
- photon-counting CT (1)
- physical therapy (1)
- physically disabled children (1)
- physiolysis (1)
- plantar (1)
- plantar pressure distribution (1)
- plasticity (1)
- platelet-rich plasma (1)
- polycaprolactone (1)
- polyethylene wear (1)
- polylactid (1)
- polymerase chain reaction (1)
- polymethylmethacrylate (1)
- porous-coated stems (1)
- posterior cruciate ligament (1)
- posterior instability (1)
- posterior tibial slope (1)
- postoperative Schmerzen (1)
- postoperative rehabilitation (1)
- postoperatriv (1)
- postural stability (1)
- pre- and post-outbreak comparison (1)
- precedes multiple-myeloma (1)
- preoperative closed reduction (1)
- preoperative pain level (1)
- prevalent fractures (1)
- primary hip prosthesis (1)
- primäre Kniegelenksendoprothese (1)
- pro-inflammatory signaling pathways (1)
- progenitor cells (1)
- proliferation (1)
- promotes (1)
- pronation (1)
- prospective clinical trial (1)
- prospektiv (1)
- prospektive klinische Studie (1)
- prostheses and implants (1)
- prosthesis-exchange (1)
- prosthetic design (1)
- proteoglycan (1)
- proximal humerus (1)
- proximal humerus fracture (1)
- proximale Humerusfraktur (1)
- präoperative Anämie (1)
- präoperatives Schmerzniveau (1)
- pseudofracture (1)
- pseudofractures (1)
- pulley lesion (1)
- qPCR (1)
- quantification (1)
- quantitative real-time PCR (1)
- questionnaire (1)
- radiation dosage (1)
- radiologische Lysesäume (1)
- radiolucent lines (1)
- randomisiert (1)
- randomisierte Studie (1)
- randomized (1)
- randomized prospective trial (1)
- randomized trial (1)
- rare bone disease (1)
- rare bone tumor (1)
- ratio body weight to surface of the stem (1)
- real-world evidence (1)
- receptor beta (1)
- receptor related protein (1)
- reerse shoulder arthoplasty (1)
- regeneration (1)
- regenerative capacity (1)
- regenerative medicine (1)
- regenerative potential (1)
- regenerative therapies (1)
- regional transient osteoporosis (1)
- register (1)
- rehabilitation (1)
- rehabilitation centre (1)
- relapsed clubfoot (1)
- renal failure (1)
- repair (1)
- replacement therapy (1)
- replicative senescence (1)
- resection arthroplasty (1)
- resistance exercise (1)
- responsiveness (1)
- responsivness (1)
- revision hip (1)
- revision surgery (1)
- revision total hip arthroplasty (1)
- rheumatoid Arthritis (1)
- rheumatoide Arthritis (1)
- rickets (1)
- ride (1)
- rigidus (1)
- risk factors (1)
- robotic (1)
- rolling and gliding mechanisms (1)
- running shoes (1)
- rupture of the rotator cuff (1)
- sFRP4 (1)
- sanders (1)
- scaffold (1)
- scaffold-free (1)
- scapula alata (1)
- scapular winging (1)
- scientific publications (1)
- scoping review (1)
- screw (1)
- segmental collapse (1)
- selenium deficiency (1)
- selenoprotein (1)
- selenoproteins (1)
- senescence‐associated secretory phenotype (1)
- septisch (1)
- serratus anterior (1)
- serum (1)
- serum amyloid A (1)
- shRNA (1)
- shape (1)
- shear stress (1)
- sheep model (1)
- shoes (1)
- short form musculoskeletal assessment questionnaire (SMFA-D) (1)
- short hip stem (1)
- shoulder funktion (1)
- shoulder infection (1)
- shoulder injuries (1)
- shoulder joint (1)
- shoulder neurolysis (1)
- shoulder replacement surgery (1)
- signaling (1)
- skeletal metastases (1)
- skeletal overexpression (1)
- skeletal progenitor cells (1)
- skiing (1)
- slope (1)
- snowboarder's ankle (1)
- snowboarder's fracture (1)
- sonography (1)
- spherical (1)
- spontaneous osteonecrosis (1)
- sports medicine (1)
- sports therapy (1)
- sports-shoes (1)
- sprain (1)
- stadienabhängige Therapie (1)
- stage-adapted (1)
- staphylococci (1)
- state of health (1)
- statistical shape model (1)
- stem cell (1)
- stem cell niche (1)
- stem-cell niche (1)
- stepwatch (1)
- stimulation (1)
- subjektive Wahrnehmung (1)
- subscapularis tear (1)
- superparamagnetic iron oxide particles (1)
- superparamagnetische Eisenoxidnanopartikel (1)
- suprascapular notch (1)
- surface replacement (1)
- surgical correction (1)
- sutures (1)
- synovia (1)
- synovial fluid (1)
- systems (1)
- tapered stem (1)
- taping (1)
- teeth (1)
- tendon (1)
- tendon tissue engineering (1)
- tendon-derived stem cell (1)
- tenogenic differentiation (1)
- therapy (1)
- three-point bending (1)
- tibial rotation (1)
- tissue regeneration (1)
- titanium screw (1)
- toll-like receptor (1)
- tooth loss (1)
- torsion (1)
- total HIP-arthroplasty (1)
- total ankle arthroplasty (1)
- total ankle replacement (1)
- total hip or knee arthroplasty (1)
- totalendoprothetischer Ersatz von Hüfte oder Knie (1)
- toxicity (1)
- trabecular bone (1)
- trabecular bone-derived mesenchymal stem cell (1)
- transcription factors (1)
- transdifferentiation (1)
- transgenic mice (1)
- transgluteal approach (1)
- translational research (1)
- transplantation (1)
- trauma (1)
- traumatische Erstluxation (1)
- traumatology (1)
- triangle method (1)
- tribology (1)
- tricompartmental knee osteoarthritis (1)
- trochlear dysplasia (1)
- tumor necrosis factor alpha (1)
- tumour malignancy (1)
- two stage (1)
- two-stage revision (1)
- unctionals analysis of 24-Hydroxylase promotor (1)
- undetermined significance (1)
- unicompartmental (1)
- unicompartmental knee arthroplasty (1)
- unicondylar (1)
- unikondylär (1)
- unklarer Signifikanz (1)
- unstable distal radius fracture (1)
- unzementiert (1)
- upper ankle (1)
- upper extremity (1)
- validity (1)
- value (1)
- variation (1)
- vasculogenesis (1)
- vdr (1)
- vertebral body (1)
- vertebral fractures (1)
- vertebrate (1)
- vibration (1)
- virus vectors (1)
- vitamin C (1)
- vitamin D deficiency (1)
- vitamin D deficiency (VDR) (1)
- vitamin D receptor (1)
- vitamin D3 (cholecalciferol, VD3) (1)
- vitamin d (1)
- vitamin d receptor (1)
- vitamin-D-receptor (1)
- volume analysis (1)
- vorderer Zugang (1)
- vorfußflexibilität (1)
- water sports (1)
- weight bearing line (1)
- white blood cell count (1)
- whole body vibration (1)
- whole-body electromyostimulation (1)
- whole-body vibration (1)
- with and without cement (1)
- wound fluid (1)
- wound irrigation (1)
- wrist pain (1)
- zebrafish (1)
- zementfrei (1)
- zementiert oder zementfrei (1)
- zementierte Hüfttotalendoprothesen (1)
- zoledronic acid (1)
- zweizeitig (1)
- zweizeitiger Prothesenwechsel (1)
- Änderungssensitivität (1)
- Östrogen Rezeptor alpha (1)
- Östrogenrezeptor beta (1)
- ß-Tricalciumphosphat (1)
- β1 integrin (1)
Institute
- Lehrstuhl für Orthopädie (378) (remove)
Sonstige beteiligte Institutionen
- IZKF Nachwuchsgruppe Geweberegeneration für muskuloskelettale Erkrankungen (7)
- Bernhard-Heine-Centrum für Bewegungsforschung (4)
- König-Ludwig-Haus Würzburg (3)
- Orthopädische Klinik und Poliklinik der Universität Würzburg (2)
- König Ludwig Haus Würzburg (1)
- König-Ludwig Haus (1)
- Lehrstuhl für Regeneration Muskuloskelettaler Gewebe (1)
- Muskuloskelettalen Zentrum Würzburg (MCW) (1)
- Muskuloskelettales Centrum Würzburg (MCW) (1)
- Orthopädische Klinik König-Ludwig-Haus (1)
Vitamin D is considered to play an important role in musculoskeletal health. It’s classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Moreover, there is an abundance of reports highlighting vitamin D deficiency and insufficiency in patients with almost innumerable diseases. Further, it is estimated that more than one billion people globally are affected by insufficient vitamin D levels. As such, research on vitamin D has been particularly popular over the past years. In orthopaedics and traumatology, most studies describe favourable effects of vitamin D in general. However, the relative importance of vitamin D is oftentimes debated. In this narrative review of the literature, we consider first, the properties of vitamin D and how vitamin D, vitamin D deficiency and the vitamin D receptor (VDR) impact on musculoskeletal health. Secondly, we provide an overview of studies reporting the prevalence of vitamin D deficiency in traumatology and diverse orthopaedic diseases including bone oncology. Lastly, we emphasise recent findings and touch on future perspectives in vitamin D research.
Variabilität der Penetranz und klinischen Manifestation der autosomal dominanten Osteopetrose Typ II
(2024)
Die autosomal dominante Osteopetrose Typ II ist eine seltene sklerosierende Skeletterkrankung, die durch heterozygote Varianten im CLCN7-Gen verursacht wird. Die klinische Manifestation umfasst ein breites Symptomspektrum. Charakteristisch sind die unvollständige Penetranz und eine hohe Variabilität der Phänotyp-Expression. Beide Phänomene führen wir am ehesten auf eine monoallelische Inaktivierung zurück.
Diese Studie war eine retrospektive Datenauswertung, die 14 ADO II-Betroffene mit klinischer Manifestation der Erkrankung sowie 5 PatientInnen mit Carrier-Status eingeschlossen hat. Diese wurden im Rahmen einer ausführlichen Diagnostik untersucht, bei der Parameter im Hinblick auf den Zustand des Skelettsystems, körperliche Funktionen und Symptome sowie die gesundheitsbezogene Lebensqualität und der Leidensdruck erfasst wurden. Diese Variablen wurden zwischen der Betroffenen- und Carrier-Gruppe verglichen, wobei die Ergebnisse humangenetischer Untersuchungen berücksichtigt wurden, welche Gene umfassten, deren Produkte im Knochenstoffwechsel eine Rolle spielen.
In 6 Stammbäumen und einem sporadischen Fall konnten 5 verschiedene heterozygote CLCN7-Varianten festgestellt werden. Zusätzlich wurden ALPL- und LRP5-Varianten entdeckt. Der Einfluss dieser zusätzlichen Varianten auf die Penetranz und die klinische Manifestation des ADO II-Phänotyps wurden diskutiert.
Es konnte festgestellt werden, dass Betroffene in allen betrachteten Bereichen, d.h. klinisch, osteodensitometrisch und laborchemisch krankheitstypische Veränderungen zeigten, wohingegen Carrier keinerlei Auffälligkeiten aufwiesen.
Die nach Alter stratifizierte Auswertung der Funktionstestung und Lebensqualität offenbarte mit zunehmendem Alter stärkere Einbußen in der Funktionsfähigkeit und der gesundheitsbezogenen Lebensqualität bei Betroffenen gegenüber den Carriern. Eine Zunahme der Krankheitssymptome und eine Verschlechterung des Gesundheitszustandes im Laufe des Lebens könnten demnach angenommen werden.
Background
Curcumin has anti-inflammatory effects and qualifies as a potential candidate for the treatment of osteoarthritis (OA). However, curcumin has limited bioavailability. Extracellular vesicles (EVs) are released by multiple cell types and act as molecule carrier during intercellular communication. We assume that EVs can maintain bioavailability and stability of curcumin after encapsulation. Here, we evaluated modulatory effects of curcumin-primed human (h)BMSC-derived EVs (Cur-EVs) on IL-1β stimulated human osteoarthritic chondrocytes (OA-CH).
Methods
CellTiter-Blue Viability- (CTB), Caspase 3/7-, and live/dead assays were used to determine range of cytotoxic curcumin concentrations for hBMSC and OA-CH. Cur-EVs and control EVs were harvested from cell culture supernatants of hBMSC by ultracentrifugation. Western blotting (WB), transmission electron microscopy, and nanoparticle tracking analysis were performed to characterize the EVs. The intracellular incorporation of EVs derived from PHK26 labeled and curcumin-primed or control hBMSC was tested by adding the labeled EVs to OA-CH cultures. OA-CH were pre-stimulated with IL-1β, followed by Cur-EV and control EV treatment for 24 h and subsequent analysis of viability, apoptosis, and migration (scratch assay). Relative expression of selected anabolic and catabolic genes was assessed with qRT-PCR. Furthermore, WB was performed to evaluate phosphorylation of Erk1/2, PI3K/Akt, and p38MAPK in OA-CH. The effect of hsa-miR-126-3p expression on IL-1β-induced OA-CH was determined using CTB-, Caspase 3/7-, live/dead assays, and WB.
Results
Cur-EVs promoted viability and reduced apoptosis of IL-1β-stimulated OA-CH and attenuated IL-1β-induced inhibition of migration. Furthermore, Cur-EVs increased gene expression of BCL2, ACAN, SOX9, and COL2A1 and decreased gene expression of IL1B, IL6, MMP13, and COL10A1 in IL-1β-stimulated OA-CH. In addition, phosphorylation of Erk1/2, PI3K/Akt, and p38 MAPK, induced by IL-1β, is prevented by Cur-EVs. Cur-EVs increased IL-1β-reduced expression of hsa-miR-126-3p and hsa-miR-126-3p mimic reversed the effects of IL-1β.
Conclusion
Cur-EVs alleviated IL-1β-induced catabolic effects on OA-CH by promoting viability and migration, reducing apoptosis and phosphorylation of Erk1/2, PI3K/Akt, and p38 MAPK thereby modulating pro-inflammatory signaling pathways. Treatment of OA-CH with Cur-EVs is followed by upregulation of expression of hsa-miR-126-3p which is involved in modulation of anabolic response of OA-CH. EVs may be considered as promising drug delivery vehicles of curcumin helping to alleviate OA.
The objective of the study was to suggest a novel quantitative assessment of acetabular bone defects based on a statistical shape model, validate the method, and present preliminary results. Two exemplary CT-data sets with acetabular bone defects were segmented to obtain a solid model of each defect pelvis. The pathological areas around the acetabulum were excluded and a statistical shape model was fitted to the remaining healthy bone structures. The excluded areas were extrapolated such that a solid model of the native pelvis per specimen resulted (i.e., each pelvis without defect). The validity of the reconstruction was tested by a leave-one-out study. Validation results showed median reconstruction errors of 3.0 mm for center of rotation, 1.7 mm for acetabulum diameter, 2.1° for inclination, 2.5° for anteversion, and 3.3 mm3 for bone volume around the acetabulum. By applying Boolean operations on the solid models of defect and native pelvis, bone loss and bone formation in four different sectors were assessed. For both analyzed specimens, bone loss and bone formation per sector were calculated and were consistent with the visual impression. In specimen_1 bone loss was predominant in the medial wall (10.8 ml; 79%), in specimen_2 in the posterior column (15.6 ml; 46%). This study showed the feasibility of a quantitative assessment of acetabular bone defects using a statistical shape model-based reconstruction method. Validation results showed acceptable reconstruction accuracy, also when less healthy bone remains. The method could potentially be used for implant development, pre-clinical testing, pre-operative planning, and intra-operative navigation. © 2018 The Authors. Journal of Orthopaedic Research® Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 9999:1–9, 2018.
In vitro co-cultures of different primary human cell types are pivotal for the testing and evaluation of biomaterials under conditions that are closer to the human in vivo situation. Especially co-cultures of macrophages and mesenchymal stem cells (MSCs) are of interest, as they are both present and involved in tissue regeneration and inflammatory reactions and play crucial roles in the immediate inflammatory reactions and the onset of regenerative processes, thus reflecting the decisive early phase of biomaterial contact with the host. A co-culture system of these cell types might thus allow for the assessment of the biocompatibility of biomaterials. The establishment of such a co-culture is challenging due to the different in vitro cell culture conditions. For human macrophages, medium is usually supplemented with human serum (hS), whereas hMSC culture is mostly performed using fetal calf serum (FCS), and these conditions are disadvantageous for the respective other cell type. We demonstrate that human platelet lysate (hPL) can replace hS in macrophage cultivation and appears to be the best option for co-cultivation of human macrophages with hMSCs. In contrast to FCS and hS, hPL maintained the phenotype of both cell types, comparable to that of their respective standard culture serum, as well as the percentage of each cell population. Moreover, the expression profile and phagocytosis activity of macrophages was similar to hS.
Cell adhesion in the multiple myeloma (MM) microenvironment has been recognized as a major mechanism of MM cell survival and the development of drug resistance. Here we addressed the hypothesis that the protein junctional adhesion molecule-A (JAM-A) may represent a novel target and a clinical biomarker in MM. We evaluated JAM-A expression in MM cell lines and in 147 MM patient bone marrow aspirates and biopsies at different disease stages. Elevated JAM-A levels in patient-derived plasma cells were correlated with poor prognosis. Moreover, circulating soluble JAM-A (sJAM-A) levels were significantly increased in MM patients as compared with controls. Notably, in vitro JAM-A inhibition impaired MM migration, colony formation, chemotaxis, proliferation and viability. In vivo treatment with an anti-JAM-A monoclonal antibody (αJAM-A moAb) impaired tumor progression in a murine xenograft MM model. These results demonstrate that therapeutic targeting of JAM-A has the potential to prevent MM progression, and lead us to propose JAM-A as a biomarker in MM, and sJAM-A as a serum-based marker for clinical stratification.
Die distale Radiusfraktur gehört zu den häufigsten Frakturen in Deutschland mit einem Inzidenzanstieg im Alter unter Betonung des weiblichen Geschlechts. Dabei zeigt sich ein zunehmender Trend in Richtung operative Versorgung, allen voran die Versorgung mittels winkelstabiler Plattensysteme. Instabile, distale Radiusfrakturen werden dabei vor geplanter operativer Versorgung im Rahmen der Initialbehandlung üblicherweise geschlossen reponiert und im Gipsverband retiniert. Ziel der vorliegenden monozentrischen, prospektiv randomisierten Studie mit zwei Studiengruppen war es herauszufinden, ob sich das Unterlassen der Reposition vor geplanter Operation nachteilig auf das Schmerzniveau in der präoperativen Phase auswirkt und ob sich durch die Dislokation Nachteile in Bezug auf den Nervus medianus im Sinne eines Traktionsschadens sowie bezüglich des klinisch-radiologischen Ausheilungsergebnisses zeigen.
Die Studie zeigte, dass das Schmerzempfinden während der präoperativen Gipsbehandlung unabhängig von einer vorherigen Reposition war. Für den primären Endpunkt an Tag 1 nach der Akutbehandlung konnte statistisch signifikante Nichtunterlegenheit der Gruppe ohne Reposition gegenüber der Gruppe mit Reposition nachgewiesen werden. Gleiches galt für Tag 2, sowohl für die absoluten Schmerzniveaus als auch für die Schmerzlinderung.
Das Unterlassen der Reposition hatte zudem keine nachteiligen Effekte auf den Nervus medianus.
Gleiches zeigte sich für das klinische und radiologische Ausheilungsergebnis. Für die funktionellen DASH- und Krimmer-Scores konnte ein Jahr postoperativ ebenfalls statistisch signifikante Nichtunterlegenheit der Gruppe ohne Reposition nachgewiesen werden.
Diese Erkenntnisse bestätigen die in der Literatur vorhandenen Ergebnisse verschiedener Studien dahingehend, dass das Unterlassen der Reposition keine nachteiligen Effekte auf das postoperative Outcome hat. Einige Studien verdeutlichen zudem, dass es nach Reposition, insbesondere bei Vorliegen gewisser Risiko- und Instabilitätsfaktoren, ohnehin zur sekundären Dislokation kommt, sodass die generelle Notwendigkeit der Reposition vor Gipsanlage sowohl vor einer operativen als auch vor einer konservativen Weiterbehandlung angezweifelt werden
muss.
Background and objectives: Cartilage surgery constitutes a standard intervention in foot and ankle procedures. Currently, there is a lack of epidemiological data on its frequency, age distribution, and surgical options for cartilage surgery. This study aimed to investigate the current landscape of cartilage surgery in Germany and identify the most common procedures from an epidemiological standpoint. Materials and methods: Medical billing and reporting data from the Federal Statistical Office of Germany, encompassing the period 2006–2020, was examined, including all foot and ankle cartilage surgical procedures (summarized under OPS codes 5-812 and 5-801). The dataset incorporated information on the affected joint, patient age and sex, and surgery type. Each surgical procedure was categorized as “debridement”, “regeneration” or “refixation”. Linear and nonlinear regression analyses were employed, with a statistical significance threshold of 0.05. Results: From the total of 136,501 procedures conducted during the study period, the most frequently performed interventions were microfracture (58,252) and chondroplasty (56,135), and thus, debridement procedures were in the leading position. The use of acellular membranes was the most used regenerative technique (n = 11,414). At the ankle joint, interventions were mostly arthroscopic and in men, while foot cartilage surgeries were preferably performed via open surgery and mostly in women. Age distribution analysis revealed two primary peaks: the first in the 20–25-year-old group (ankle and foot) and the second in the 45–50-year-old group (ankle) and 55–60-year-old group (foot). Refixation and regenerative procedures were more frequent among younger individuals, while debriding procedures were more frequent among older individuals. Regenerative procedures, particularly in the ankle, significantly increased over time. Conclusions: Cartilage surgery of the foot and ankle was common, with two primary age groups predominantly affected. Notably, recent years have witnessed a considerable rise in cartilage regenerative procedures.
In March 2020, Germany imposed a nationwide lockdown to curb the spread of COVID-19, prompting questions about the impact on the incidence of common fractures. This study examined 15 fracture types in pre-outbreak (2010–2019) and post-outbreak (2020–2021) periods, using data categorized by age (18–64 years, 65 years) and sex (male, female). Linear regression assessed annual growth rates, and mean fracture numbers were compared across periods for significant differences. Results indicated a positive correlation between fracture incidence rates and time for various types, such as cervical, thoracic, lumbar, and pelvic spine fractures, rib fractures, femoral neck, pertrochanteric femur, femoral shaft, and ankle fractures. Frequencies of proximal humerus, distal radius, femoral neck, pertrochanteric femur, femoral shaft, and ankle fractures in 2020 and 2021 were within predicted ranges from previous years. However, rib fractures and spinal fractures (cervical, thoracic, lumbar, and pelvic spine) occurred less frequently during this time. Notably, this study found a consistent decline in most fracture types for individuals aged 18–64 after the pandemic’s onset, while the fracture incidence of hip fractures, often referred to as fragility fractures, for those over 65 remained unchanged. Fibula fractures showed the most considerable decrease in both age groups. In conclusion, the COVID-19 pandemic substantially impacted fracture incidence, with lower rates among individuals under 65 and unchanged fragility fractures in the elderly population.
Ultra-high-resolution photon-counting detector CT arthrography of the ankle: a feasibility study
(2023)
This study was designed to investigate the image quality of ultra-high-resolution ankle arthrography employing a photon-counting detector CT. Bilateral arthrograms were acquired in four cadaveric specimens with full-dose (10 mGy) and low-dose (3 mGy) scan protocols. Three convolution kernels with different spatial frequencies were utilized for image reconstruction (ρ\(_{50}\); Br98: 39.0, Br84: 22.6, Br76: 16.5 lp/cm). Seven radiologists subjectively assessed the image quality regarding the depiction of bone, hyaline cartilage, and ligaments. An additional quantitative assessment comprised the measurement of noise and the computation of contrast-to-noise ratios (CNR). While an optimal depiction of bone tissue was achieved with the ultra-sharp Br98 kernel (S ≤ 0.043), the visualization of cartilage improved with lower modulation transfer functions at each dose level (p ≤ 0.014). The interrater reliability ranged from good to excellent for all assessed tissues (intraclass correlation coefficient ≥ 0.805). The noise levels in subcutaneous fat decreased with reduced spatial frequency (p < 0.001). Notably, the low-dose Br76 matched the CNR of the full-dose Br84 (p 0.999) and superseded Br98 (p < 0.001) in all tissues. Based on the reported results, a photon-counting detector CT arthrography of the ankle with an ultra-high-resolution collimation offers stellar image quality and tissue assessability, improving the evaluation of miniscule anatomical structures. While bone depiction was superior in combination with an ultra-sharp convolution kernel, soft tissue evaluation benefited from employing a lower spatial frequency.
Der MPFL-Ersatz ist ein gängiges Therapieverfahren zur Behandlung einer patellofemoralen Instabilität. Die Operationstechniken unterscheiden sich zumeist an der patellaren Fixationsmethode und der Auswahl der Transplantate. Biomechanische Studien, welche sich mit den Eigenschaften implantatfreier ossärer Fixationsmethoden beim MPFL-Ersatz unter Verwendung künstlicher Transplantate beschäftigen gibt es nach aktueller Recherche nicht. Ziel dieser Arbeit war es, die biomechanischen Eigenschaften zweier patellarer Bohrkanalfixationstechniken beim MPFL-Ersatz mit unterschiedlichem künstlichen Bandersatzmaterial zu ermitteln. Die Hypothese war, dass die biomechanischen Eigenschaften in Elongation, Steifigkeit, Primärstabilität und maximaler Ausreißkraft mit denen der bereits etablierten Verfahren und dem nativen MPFL vergleichbar sind. Hierzu wurden 80 porcine Kniescheiben randomisiert in 8 Gruppen aufgeteilt und getestet. In den Gruppen 1-4 wurden parallele, transpatellare Bohrkanäle mit Tapes der Breiten 2 mm, 3 mm, 4 mm und 5 mm getestet. In den Gruppen 5-8 wurden V-Kanal-Fixationsmethoden mit Bändern der Breite von 2 mm, 3 mm, 4 mm und 5 mm untersucht. Zusätzlich wurden die biomechanischen Grundeigenschaften der nativen Tapes ermittelt. Alle Tests durchliefen jeweils drei Messabschnitte. Hierbei fand zunächst eine Präkonditionierung mit 10 Zyklen zwischen 5 N und 20 N statt. Daraufhin folgte eine zyklische Belastung mit 1000 Zyklen zwischen 5 N und 50 N. Am Ende wurde eine maximale Kraftapplikation bis zum Versagen der Fixationskomplexe durchgeführt. Im Rahmen der Messungen wurden Elongation, Steifigkeit, Yield Load und Maximum Load bestimmt. Es konnten Unterschiede zwischen den beiden Fixationsmethoden und den verwendeten Tapes festgestellt werden. Alle acht Gruppen zeigten eine höhere Primärstabilität als das humane MPFL. Bezogen auf die biomechanischen Eigenschaften und den Versagensmechanismus konnte in dieser Studie ein Vorteil der parallelen transpatellaren Bohrkanäle gegenüber den V- Kanaltechniken festgestellt werden. Die Werte mit der höchsten maximalen Ausreißkraft wurden in Gruppe 3 (631,6 ± 83,1 N) und Gruppe 1 (592,9 ± 170,1 N) gemessen. Diese zeigten eine höhere Primärstabilität mit geringerer Elongation und Steifigkeit im Vergleich zu den in der aktuellen Literatur beschriebenen biomechanischen Studien, welche sich mit unterschiedlichen und teilweise bereits etablierten MPFL-Ersatzverfahren beschäftigten. Eine implantatfreie MPFL-Rekonstruktion mit transpatellaren parallelen Bohrkanälen unter Verwendung eines 2 mm Fiber Tapes (Fa. Arthrex) oder eines 4 mm Tapes (Fa. Topester) könnten dementsprechend eine gute Alternative zur operativen Therapie einer patellofemoralen Instabilität sein.
Introduction
Diagnosis and treatment of insertional tendinopathy of the Achilles tendon (IAT) remains a challenge. The aim of this study was to assess the influence of pre-operative radiological pathologies on the patient-reported outcomes following open debridement of all pathologies for IAT.
Materials and methods
In this IRB-approved retrospective correlation and comparative study, patients with pre-operative imaging were identified from the authors’ retrospective IAT database comprising of 118 patients. All were treated by a standardized surgical treatment strategy utilizing a midline, transachillary approach and debridement of all pathologies. A total of fifteen radiologic parameters were measured on radiographs (RX) and MRI. The patient-reported outcomes were assessed using the Victorian Institute of Sport Assessment-Achilles questionnaire (VISA-A-G) and the general health questionnaire SF-12 at a minimum follow-up of 12 months. The data are presented as mean ± SD (95% CI).
Results
88 patients (74.6%) with an average age of 50 ± 12 (47–52) years were included. Radiographs were available in 68 patients and MRI in 53. The mean follow-up was 3.8 ± 1.9 (3.4–4.3) years. The overall VISA-A-G was 81 ± 22 (77–86), the SF-12 PCS 54 ± 7 (52–55), and the SF-12 MCS 52 ± 9 (50–54) points. None of the assessed radiological parameters had a significant influence on the patient-reported outcome following surgical treatment for IAT.
Conclusion
In this retrospective correlation study, no significant association was found between preoperative radiographic and MRI radiologic parameters for IAT and postoperative patient-reported outcomes (VISA-A-G and SF-12).
Einleitung:
Die Ätiologie der Early Onset Arthrose (EOA) der Schulter ist bislang ungeklärt. Aufgrund des Einflusses der Muskeln der Rotatorenmanschette (RM) auf die glenohumerale Kinematik werden muskuläre Ursachen diskutiert. Ziel der Studie war es, entsprechende Faktoren anhand von Volumenmessungen der RM und Untersuchungen der angrenzenden knöchernen Strukturen in der MRT-Bildgebung sowie der Erfassung patientenspezifischer Charakteristika zu identifizieren.
Methoden:
In einer Fall-Kontroll-Studie wurden Schultern von 15 PatientInnen (14 Männer, 1 Frau) mit einer Omarthrose vor dem 60. Lebensjahr und 13 Kontrollpersonen (ausschließlich Männer) untersucht. Dabei wurden anthropometrische Körpermessungen sowie klinische Charakteristika erhoben. Anhand von MRT-Bildern wurden die Volumina der RM mittels manueller Umrandung der einzelnen Muskelquerschnitte berechnet. Weiterhin wurden die Winkel zwischen Coracoid bzw. Spina scapulae und Scapulakörper gemessen. Die Stellung der Scapula zum Thorax wurde anhand des Winkels der Scapula zur Tischebene erhoben. Zudem wurden die Glenoidretroversion, -morphologietypen und Humeruskopfsubluxation ermittelt. Die Auswertung erfolgte anhand deskriptiver und vergleichender statistischer Verfahren sowie logistischer und linearer Regressionsanalysen.
Ergebnisse:
Die Volumina der RM von PatientInnen mit EOA unterschieden sich weder absolut noch im relativen Verhältnis von denen der Kontrollpersonen. Dagegen konnten im Vergleich signifikant höhere Werte des Thoraxumfangs und -durchmessers, des Körpergewichts sowie des BMI bei erkrankten Personen nachgewiesen werden. Weiterhin übten diese signifikant häufiger Berufe aus, die mehr als 1400 kcal pro Tag verbrauchten. Das Risiko einer EOA nahm zu, je steiler die Scapula zum Thorax stand. PatientInnen mit B2-Glenoid wiesen signifikant größere Winkel zwischen Coracoid und Scapulakörper sowie höhere Werte des transversalen Thoraxdurchmessers auf, als erkrankte Personen mit einem B1-Glenoid. Unabhängig von einer Erkrankung mit EOA zeigte sich, dass das Ausüben einer Überkopfsportart mit einem höheren Subluxationsindex assoziiert war.
Fazit:
Während die RM keine Auffälligkeiten bei PatientInnen mit EOA zeigte, waren ein männliches Geschlecht, der BMI, die Thoraxform und Scapulastellung, sowie die Ausübung bestimmter Berufe und Sportarten mit der Erkrankung assoziiert. Weitere Studien müssen folgen, um diese Risikofaktoren bei EOA genauer zu untersuchen und mögliche Therapiekonzepte zu entwickeln. Dabei sollte auch die periphere Schultermuskulatur (z. B. M. teres major oder M. pectoralis major) in die Untersuchungen miteinbezogen werden.
Purpose
Hypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis. Although the exact pathomechanism remains poorly understood, hypertrophic de-differentiation of chondrocytes also poses a major challenge in the cell-based repair of hyaline cartilage using mesenchymal stromal cells (MSCs). While different members of the transforming growth factor beta (TGF-β) family have been shown to promote chondrogenesis in MSCs, the transition into a hypertrophic phenotype remains a problem. To further examine this topic we compared the effects of the transcription growth and differentiation factor 5 (GDF-5) and the mutant R57A on in vitro chondrogenesis in MSCs.
Methods
Bone marrow-derived MSCs (BMSCs) were placed in pellet culture and in-cubated in chondrogenic differentiation medium containing R57A, GDF-5 and TGF-ß1 for 21 days. Chondrogenesis was examined histologically, immunohistochemically, through biochemical assays and by RT-qPCR regarding the expression of chondrogenic marker genes.
Results
Treatment of BMSCs with R57A led to a dose dependent induction of chondrogenesis in BMSCs. Biochemical assays also showed an elevated glycosaminoglycan (GAG) content and expression of chondrogenic marker genes in corresponding pellets. While treatment with R57A led to superior chondrogenic differentiation compared to treatment with the GDF-5 wild type and similar levels compared to incubation with TGF-ß1, levels of chondrogenic hypertrophy were lower after induction with R57A and the GDF-5 wild type.
Conclusions
R57A is a stronger inducer of chondrogenesis in BMSCs than the GDF-5 wild type while leading to lower levels of chondrogenic hypertrophy in comparison with TGF-ß1.
The AMADEUS score is not a sufficient predictor for functional outcome after high tibial osteotomy
(2023)
Purpose
The Area Measurement And Depth Underlying Structures (AMADEUS) classification system has been proposed as a valuable tool for magnetic resonance (MR)-based grading of preoperatively encountered chondral defects of the knee joint. However, the potential relationship of this novel score with clinical data was yet to determine. It was the primary intention of this study to assess the correlative relationship of the AMADEUS with patient reported outcome scores in patients undergoing medial open-wedge high tibial valgus osteotomy (HTO). Furthermore, the arthroscopic ICRS (International Cartilage Repair Society) grade evaluation was tested for correlation with the AMADEUS classification system.
Methods
This retrospective, monocentric study found a total of 70 individuals that were indicated for HTO due to degenerative chondral defects of the medial compartment between 2008 and 2019. A preoperative MR image as well as a pre-osteotomy diagnostic arthroscopy for ICRS grade evaluation was mandatory for all patients. The Knee Osteoarthritis Outcome Score (KOOS) including its five subscale scores (KOOS-ADL, KOOS-QOL, KOOS-Sports, KOOS-Pain, KOOS-Symptoms) was obtained preoperatively and at a mean follow-up of 41.2 ± 26.3 months. Preoperative chondral defects were evaluated using the AMADEUS classification system and the final AMADEUS scores were correlated with the pre- and postoperative KOOS subscale sores. Furthermore, arthroscopic ICRS defect severity was correlated with the AMADEUS classification system.
Results
There was a statistically significant correlation between the AMADEUS BME (bone marrow edema) subscore and the KOOS Symptoms subscore at the preoperative visit (r = 0.25, p = 0.04). No statistically significant monotonic association between the AMADEUS total score and the AMADEUS grade with pre- and postoperative KOOS subscale scores were found. Intraoperatively obtained ICRS grade did reveal a moderate correlative relation with the AMADEUS total score and the AMADEUS grade (r = 0.28, p = 0.02).
Conclusions
The novel AMADEUS classification system largely lacks correlative capacity with patient reported outcome measures in patients undergoing HTO. The MR tomographic appearance of bone marrow edema is the only parameter predictive of the clinical outcome at the preoperative visit.
The treatment landscape in multiple myeloma (MM) is shifting from genotoxic drugs to immunotherapies. Monoclonal antibodies, immunoconjugates, T-cell engaging antibodies and CART cells have been incorporated into routine treatment algorithms, resulting in improved response rates. Nevertheless, patients continue to relapse and the underlying mechanisms of resistance remain poorly understood. While Impaired death receptor signaling has been reported to mediate resistance to CART in acute lymphoblastic leukemia, this mechanism yet remains to be elucidated in context of novel immunotherapies for MM. Here, we describe impaired death receptor signaling as a novel mechanism of resistance to T-cell mediated immunotherapies in MM. This resistance seems exclusive to novel immunotherapies while sensitivity to conventional anti-tumor therapies being preserved in vitro. As a proof of concept, we present a confirmatory clinical case indicating that the FADD/BID axis is required for meaningful responses to novel immunotherapies thus we report impaired death receptor signaling as a novel resistance mechanism to T-cell mediated immunotherapy in MM.
Purpose
To compare the performance of the dominant and nondominant hand during fundamental arthroscopic simulator training.
Methods
Surgical trainees who participated in a 2-day simulator training course between 2021 and 2023 were classified, according to their arthroscopic experience in beginners and competents. Only right-handed individuals with complete data sets were included in the study. Ambidexterity was trained using a box trainer (Fundamentals of Arthroscopic Surgery Training, Virtamed AG, Schlieren, Switzerland).Two tasks, periscoping for learning camera guidance and triangulation for additional instrument handling, were performed 4 times with the camera in the dominant hand and then in the nondominant hand. For each task, exercise time, camera path length, and instrument path length were recorded and analyzed.
Results
Out of 94 participants 74 right-handed individuals (22 females, 52 males) were classified to novices (n = 43, less than 10 independently performed arthroscopies) and competents (n = 31, more than 10 independently performed arthroscopies). Competents performed significantly better than novices. No significant difference was found after changing the guiding hand for the camera from the dominant to the nondominant hand regarding the camera path length and the instrument path length. Notably, tasks were performed even faster when using the camera in the nondominant hand.
Conclusions
Our data demonstrate that the learned manual skills during basic arthroscopic training are quickly transferred to the contralateral side. In consequence, additional fundamental skills training for camera guidance and instrument handling of the nondominant hand are not necessary.
Clinical Relevance
For skillful arthroscopy, camera guidance and instrument handing must be equally mastered with both hands. It is important to understand how hand dominance may affect learning during arthroscopic simulator training.
The pro-inflammatory phase of bone healing, initiated by platelet activation and eventually hematoma formation, impacts bone marrow mesenchymal stromal cells (MSCs) in unknown ways. Here, we created platelet-rich plasma (PRP) hydrogels to study how platelet-derived factors modulate functional properties of encapsulated MSCs in comparison to a non-inflammatory fibrin (FBR) hydrogel environment. MSCs were isolated from human bone marrow, while PRP was collected from pooled apheresis thrombocyte concentrates and used for hydrogel preparation. After their encapsulation in hydrogels for 72 h, retrieved MSCs were analyzed for immunomodulatory activities, apoptosis, stem cell properties, senescence, CD9\(^+\), CD63\(^+\) and CD81\(^+\) extracellular vesicle (EV) release, and metabolism-related changes. PRP-hydrogels stimulated immunosuppressive functions of MSCs, along with their upregulated susceptibility to cell death in communication with PBMCs and augmented caspase 3/7 activity. We found impaired clonal growth and cell cycle progression, and more pronounced β-galactosidase activity as well as accumulation of LC3-II-positive vacuoles in PRP-MSCs. Stimuli derived from PRP-hydrogels upregulated AKT and reduced mTOR phosphorylation in MSCs, which suggests an initiation of survival-related processes. Our results showed that PRP-hydrogels might represent a metabolically stressful environment, inducing acidification of MSCs, reducing polarization of the mitochondrial membrane and increasing lipid accumulation. These features were not detected in FBR-MSCs, which showed reduced CD63\(^+\) and CD81\(^+\) EV production and maintained clonogenicity. Our data revealed that PRP-derived hematoma components cause metabolic adaptation of MSCs followed by increased immune regulatory functions. For the first time, we showed that PRP stimuli represent a survival challenge and “apoptotic priming” that are detrimental for stem cell-like growth of MSCs and important for their therapeutic consideration.
Lower limb bone geometry in adult individuals with X-linked hypophosphatemia: an observational study
(2022)
Summary
We assessed lower-limb geometry in adults with X-linked hypophosphatemia (XLH) and controls. We found large differences in multiple measures including femoral and tibial torsion, bowing and cross-sectional area and acetabular version and coverage which may contribute to clinical problems such as osteoarthritis, fractures and altered gait common in XLH.
Purpose
Individuals with X-linked hypophosphatemia (XLH) are at risk of lower-limb deformities and early onset of osteoarthritis. These two factors may be linked, as altered biomechanics is a risk factor for osteoarthritis. This exploratory evaluation aims at providing clues and concepts for this association to facilitate future larger-scale and longitudinal studies on that aspect.
Methods
For this observational study, 13 patients with XLH, aged 18–65 years (6 female), were compared with sex-, age- and weight-matched healthy individuals at a single German research centre. Femoral and hip joint geometry, including femoral and tibial torsion and femoral and tibial shaft bowing, bone cross-sectional area (CSA) and acetabular version and coverage were measured from magnetic resonance imaging (MRI) scans.
Results
Total femoral torsion was 29° lower in individuals with XLH than in controls (p < 0.001), mainly resulting from lower intertrochanteric torsion (ITT) (p < 0.001). Femoral lateral and frontal bowing, tibial frontal bowing, mechanical axis, femoral mechanical–anatomical angle, acetabular version and acetabular coverage were all greater and tibial torsion lower in individuals with XLH as compared to controls (all p < 0.05). Greater femoral total and marrow cavity CSA, greater tibial marrow cavity CSA and lower cortical CSA were observed in XLH (all p < 0.05).
Discussion
We observed large differences in clinically relevant measures of tibia and particularly femur bone geometry in individuals with XLH compared to controls. These differences may plausibly contribute to clinical manifestations of XLH such as early-onset osteoarthritis, pseudofractures and altered gait and therefore should be considered when planning corrective surgeries.