Refine
Has Fulltext
- yes (38)
Is part of the Bibliography
- yes (38)
Year of publication
Document Type
- Journal article (35)
- Doctoral Thesis (2)
- Preprint (1)
Keywords
- biodiversity (3)
- cancer (3)
- microbiome (3)
- metagenomics (2)
- species richness (2)
- turnover (2)
- 3D-conformal radiotherapy (1)
- Accurate (1)
- Acids (1)
- Annotation (1)
Author
- Keil, Thomas (4)
- Bork, Peer (3)
- Becher, Heiko (2)
- Brenner, Hermann (2)
- Coelho, Luis Pedro (2)
- Floren, Andreas (2)
- Germer, Christoph-Thomas (2)
- Haaf, Thomas (2)
- Hauke, Jan (2)
- Henderson, A. John (2)
- Hertl, Michael (2)
- Hünig, Thomas (2)
- Janni, Wolfgang (2)
- Jöckel, Karl-Heinz (2)
- Kastner, Carolin (2)
- Kraft, Peter (2)
- Lau, Susanne (2)
- Lieb, Wolfgang (2)
- Meindl, Alfons (2)
- Müller, Jörg (2)
- Schmidt, Börge (2)
- Schmidt, Enno (2)
- Schmidt, Stefan (2)
- Schmidt, Stefanie (2)
- Schmidt, Thomas (2)
- Schmidt, Thomas S. B. (2)
- Schmutzler, Rita K. (2)
- Specker, Christof (2)
- Sticherling, Michael (2)
- Sunagawa, Shinichi (2)
- Thorn, Simon (2)
- Tony, Hans-Peter (2)
- Wiegel, Thomas (2)
- Wiegering, Armin (2)
- Zeller, Georg (2)
- de Jongste, Johan C. (2)
- Aberlenc, Henri-Pierre (1)
- Adam, Dušan (1)
- Ade, Carsten P. (1)
- Aebersold, Daniel M. (1)
- Ahearn, Thomas (1)
- Ahrens, Wolfgang (1)
- Aigner, Achim (1)
- Akhmetzhanova, Asem A. (1)
- Akhyari, Payam (1)
- Albert, Michael H. (1)
- Almanzar, Giovanni (1)
- Almeida, Alexandre (1)
- Altmüller, Janine (1)
- Alves, Renato (1)
- Alves, Renato J. C. (1)
- Andersen, Anne-Marie Nybo (1)
- Andrulis, Irene L. (1)
- Ang, Wei Q. (1)
- Ankermann, Tobias (1)
- Annesi-Maesano, Isabella (1)
- Anton-Culver, Hoda (1)
- Antão, Laura H. (1)
- Appeltans, Ward (1)
- Arcos, José Manuel (1)
- Arends, Lidia R. (1)
- Aringer, Martin (1)
- Armitage, Melanie E. (1)
- Arndt, Volker (1)
- Arnold, Andreas (1)
- Arnold, Haley (1)
- Arnold, Norbert (1)
- Arolt, Volker (1)
- Aronson, Kristan J. (1)
- Arshad, S. Hasan (1)
- Atschekzei, Faranaz (1)
- Auber, Bernd (1)
- Augustinsson, Annelie (1)
- Avila, Anne (1)
- Ayyappan, Narayanan (1)
- Baaken, Dan (1)
- Backert, Steffen (1)
- Bader, Peter (1)
- Badihi, Gal (1)
- Baechle, Christina (1)
- Bail, Johannes (1)
- Baird, Andrew H. (1)
- Bakhtiar, Shahrzad (1)
- Balke, Michael (1)
- Baltic, Svetlana (1)
- Baluapuri, Apoorva (1)
- Banas, Bernhard (1)
- Banas, Miriam C. (1)
- Barabas, Sascha (1)
- Barbosa, Miguel (1)
- Barit, David (1)
- Barreto, Tiago Egydio (1)
- Barrios, Hector (1)
- Barros, Henrique (1)
- Barthel, Konstanze (1)
- Bartkowiak, Detlef (1)
- Basset, Yves (1)
- Basterrechea, Mikel (1)
- Bates, Amanda E. (1)
- Bauerfeind, Anja (1)
- Baumann, Ulrich H. (1)
- Baurecht, Hansjörg (1)
- Beane Freeman, Laura E. (1)
- Becker, Lore (1)
- Beckers, Johannes (1)
- Beckmann, Matthias W. (1)
- Beeghly-Fadiel, Alicia (1)
- Behrends, Uta (1)
- Behrens, Sabine (1)
- Beider, Renata (1)
- Beissert, Stefan (1)
- Bekes, Inga (1)
- Bellgrove, Alecia (1)
- Belmaker, Jonathan (1)
- Belohradsky, Bernd H. (1)
- Benedetti-Cecchi, Lisandro (1)
- Benjamin, Caryl S. (1)
- Bergner, Raoul (1)
- Bergsten, Emma (1)
- Berking, Carola (1)
- Bermisheva, Marina (1)
- Bernbeck, Benedikt (1)
- Bernuth, Horst von (1)
- Besch, Robert (1)
- Bett, Brian J. (1)
- Beyersdorf, Niklas (1)
- Biegner, Anika-Kerstin (1)
- Bielack, Stefan (1)
- Bisgaard, Hans (1)
- Bismarck, Philipp von (1)
- Bjorkman, Anne D. (1)
- Blaser, Rainer (1)
- Blettner, Maria (1)
- Bley, Thorsten A. (1)
- Bloch, Christopher P. Bloch (1)
- Blomqvist, Carl (1)
- Blowes, Shane A. (1)
- Bode, Sebastian (1)
- Boesecke, Christoph (1)
- Bogdanova, Natalia V. (1)
- Boivin, Valérie (1)
- Bojesen, Stig E. (1)
- Bolla, Manjeet K. (1)
- Bonebrake, Timothy C. (1)
- Borde, Julika (1)
- Borte, Michael (1)
- Borte, Stephan (1)
- Bouzigon, Emmanuelle (1)
- Bow, Ho (1)
- Boyd, Susan (1)
- Bozicevic, Vedran (1)
- Bradford, Matt (1)
- Bragina, Elena Yu (1)
- Brand, Tilman (1)
- Brauch, Hiltrud (1)
- Braun-Fahrländer, Charlotte (1)
- Braunschweig, Holger (1)
- Bridle, Jonathan R. (1)
- Brooks, Andrew J. (1)
- Brown, James H. (1)
- Bruelheide, Helge (1)
- Brummel, Bastian (1)
- Buchheidt, Dieter (1)
- Budde, Klemens (1)
- Budy, Phaedra (1)
- Buhl, Timo (1)
- Burgwinkel, Philip (1)
- Burmester, Gerd (1)
- Burwinkel, Barbara (1)
- Bässler, Claus (1)
- Böhme, Angelika (1)
- Böhmer, Dirk (1)
- Błażewicz, Magdalena (1)
- Canzian, Federico (1)
- Carvalho, Fernando (1)
- Castañeda-Moya, Edward (1)
- Castaño-Meneses, Gabriela (1)
- Cazzolla Gatti, Roberto (1)
- Chamblee, John F. (1)
- Chan, Tsun L. (1)
- Chang-Claude, Jenny (1)
- Chanock, Stephen J. (1)
- Chase, Tory J. (1)
- Chatzi, Leda (1)
- Chehab, Gamal (1)
- Chen, Chaolun Allen (1)
- Chittka, Dominik (1)
- Choi, Ji-Yeob (1)
- Christiansen, Hans (1)
- Cichon, Sven (1)
- Cizek, Lukas (1)
- Clarke, Christine L. (1)
- Classen, Carl F. (1)
- Coelho, Luiis P. (1)
- Collinge, Sharon K. (1)
- Condit, Richard (1)
- Cooper, Elisabeth J. (1)
- Corbara, Bruno (1)
- Cornelissen, J. Hans C. (1)
- Cornely, Oliver A. (1)
- Corpeleijn, Eva (1)
- Correia, Sofia (1)
- Costea, Paul I (1)
- Costea, Paul I. (1)
- Costea, Paul Igor (1)
- Cotano, Unai (1)
- Couch, Fergus J. (1)
- Craig, Leone C. (1)
- Cramer, Holger (1)
- Crow, Shannan Kyle (1)
- Cuenca, Miguelangel (1)
- Curletti, Gianfranco (1)
- Cuénoud, Philippe (1)
- Czarnecki-Maulden, Gail (1)
- Czene, Kamila (1)
- Daly, Mary B. (1)
- Damasceno, Gabriella (1)
- Dandekar, Thomas (1)
- Danquah, Ina (1)
- Davies, Claire H. (1)
- Davis, Robert A. (1)
- Day, Frank P. (1)
- De Bakker, Domir (1)
- Deckert, Andreas (1)
- Degraer, Steven (1)
- Deinlein, Hanna (1)
- Dejean, Alain (1)
- Delabie, Jacques H. C. (1)
- Demenais, Florence (1)
- Deml, Ludwig (1)
- Denk, Sarah (1)
- Dennis, Joe (1)
- Descombes, Patrick (1)
- Deutz, Peter (1)
- Devereux, Graham (1)
- Devilee, Peter (1)
- Didham, Raphael K. (1)
- Diefenbacher, Markus E. (1)
- Dilloo, Dagmar (1)
- Ding, Zhaoping (1)
- Dirks, Johannes (1)
- Ditsch, Nina (1)
- Dizier, Marie-Hélène (1)
- Dogaru, Cristian (1)
- Doherty, Tim S. (1)
- Domschke, Katharina (1)
- Dornelas, Maria (1)
- Dornquast, Christina (1)
- Dostal, Miroslav (1)
- Duchen, Karel (1)
- Duffy, David L. (1)
- Duffy, J. Emmett (1)
- Duijts, Liesbeth (1)
- Dunn, Timothy E. (1)
- Dunnig, Alison (1)
- Durigan, Giselda (1)
- Dwek, Miriam (1)
- Dworniczak, Bernd (1)
- Dörk, Thilo (1)
- Dörner, Thomas (1)
- Dückers, Gregor (1)
- Easton, Douglas F. (1)
- Eccles, Diana M. (1)
- Edelist, Dor (1)
- Edgar, Graham J. (1)
- Ege, Markus (1)
- Egerer, Gerlinde (1)
- Eggesbø, Merete (1)
- Ehl, Stephan R. (1)
- Eichinger, Anna (1)
- Eilers, Martin (1)
- Ekici, Arif B. (1)
- El Hajj, Nady (1)
- El-Helou, Sabine M. (1)
- Elahi, Robin (1)
- Elmendorf, Sarah C. (1)
- Eming, Rüdiger (1)
- Endres, Stefan (1)
- Enemar, Anders (1)
- Engel, Christoph (1)
- Englmeier, Jana (1)
- Erfurt-Berge, Cornelia (1)
- Eriksson, Mikael (1)
- Ernest, S. K. Morgan (1)
- Ernst, Corinna (1)
- Ernst, Diana (1)
- Ertl, Georg (1)
- Escribano, Rubén (1)
- Esparza-Gordillo, Jorge (1)
- Estiarte, Marc (1)
- Evans, Brian S. (1)
- Evans, D. Gareth (1)
- Ewald, Jörg (1)
- Fagan, Laura L. (1)
- Fan, Tung-Yung (1)
- Fantini, Maria P. (1)
- Farneda, Fábio Z. (1)
- Fasching, Peter A. (1)
- Fasshauer, Maria (1)
- Faust, Ulrike (1)
- Fenz, Susanne (1)
- Ferreira, Manuel A. R. (1)
- Fidelis, Alessandra (1)
- Fiehn, Christoph (1)
- Figueroa, Jonine (1)
- Finn, Robert D. (1)
- Fischer-Betz, Rebecca (1)
- Fitt, Robert (1)
- Flaig, Michael (1)
- Fleck, Martin (1)
- Flentje, Michael (1)
- Flyger, Henrik (1)
- Foell, Dirk (1)
- Forastiere, Francesco (1)
- Forslund, Sofia K. (1)
- Fosaa, Anna Maria (1)
- Fournier, Coralie (1)
- Franco, Geraldo Antonio Daher Correa (1)
- Frank, Grace E. (1)
- Franke, Andre (1)
- Fraschka, Sabine (1)
- Fraser, William R. (1)
- Freidin, Maxim B. (1)
- Freivogel, Klaus (1)
- Frey, Urs (1)
- Fricke, Julia (1)
- Fricke, Ute (1)
- Friebe, Daniela (1)
- Fritschi, Lin (1)
- Fuchs, Helmut (1)
- Fölster-Holst, Regina (1)
- Gabrielson, Marike (1)
- Gaffal, Evelyn (1)
- Gago-Dominguez, Manuela (1)
- Gailus-Durner, Valerie (1)
- Ganuza, Cristina (1)
- Gao, Chi (1)
- Gapstur, Susan M. (1)
- García, Hernando (1)
- García-Closas, Montserrat (1)
- García-Sáenz, José A. (1)
- Gastell, Sylvia (1)
- Gaudet, Mia M. (1)
- Geberzahn, Linda (1)
- Gehrig, Andrea (1)
- Gehring, Ulrike (1)
- Geis, Christian (1)
- Genuneit, Jon (1)
- Gerhard, Markus (1)
- Germing, Ulrich (1)
- Gerschmann, Stev (1)
- Geverts, Bart (1)
- Ghadjar, Pirus (1)
- Ghosh, Sujal (1)
- Gieger, Christian (1)
- Giles, Graham G. (1)
- Girschick, Hermann (1)
- Givan, Or (1)
- Goebeler, Matthias (1)
- Goetze, Katharina (1)
- Goldberg, Mark S. (1)
- Goldgar, David E. (1)
- Gorgone-Barbosa, Elizabeth (1)
- Gori, Davide (1)
- Gould, William A. (1)
- Graf, Dagmar (1)
- Graf, Norbert (1)
- Graf, Saskia Anna (1)
- Greil, Johann (1)
- Gries, Corinna (1)
- Grill, Sabine (1)
- Grimbacher, Bodo (1)
- Groeneweg, Femke L. (1)
- Grossman, Gary D. (1)
- Groß, Eva (1)
- Groß-Wieltsch, Ute (1)
- Grund, Henrike (1)
- Grunke, Mathias (1)
- Guenél, Pascal (1)
- Gutierréz, Julio R. (1)
- Günther, Kathrin (1)
- Haas, Judith (1)
- Haase, Gabriele (1)
- Habicht, Antje (1)
- Hackmann, Karl (1)
- Haeberle, Lothar (1)
- Haenicke, Henriette (1)
- Haensel, Maria (1)
- Haferkamp, Sebastian (1)
- Haferlach, Torsten (1)
- Hahnen, Eric (1)
- Haimann, Christopher A. (1)
- Hakonarson, Hakon (1)
- Hale, Stephen (1)
- Hall, Per (1)
- Hamann, Ute (1)
- Handgretinger, Rupert (1)
- Hanitsch, Leif G. (1)
- Hanke, Wojciech (1)
- Hankir, Mohammed (1)
- Harmon, Mark E. (1)
- Harte, John (1)
- Hartman, Mikael (1)
- Haskins, Gary (1)
- Haubitz, Marion (1)
- Hauck, Fabian (1)
- Hauenherm, Anja (1)
- Haussmann, Alexander (1)
- Hayward, Matthew R. (1)
- Hayward, Matthew Robert (1)
- Hedrich, Christian M. (1)
- Heeg, Maximilian (1)
- Hein, Alexander (1)
- Heine, Sabine (1)
- Heinig, Matthias (1)
- Heintz-Buschart, Anna (1)
- Heinz, Werner (1)
- Heinzmann, Andrea (1)
- Heitmann, Stefan (1)
- Hellige, Antje (1)
- Hendricks, Anne (1)
- Henes, Joerg (1)
- Henes, Jörg (1)
- Henshaw, Donald L. (1)
- Hentschel, Julia (1)
- Herbert, Paul D. N. (1)
- Hermanutz, Luise (1)
- Hermeking, Heiko (1)
- Herold, Natalie (1)
- Herrmann, Alexander M. (1)
- Herrmann, Friedrich (1)
- Herzog, Anna L. (1)
- Hesse, Julia (1)
- Heude, Barbara (1)
- Heß, Ursula (1)
- Hidalgo, Pamela (1)
- Hielscher, Thomas (1)
- Higuchi, Pedro (1)
- Hillemanns, Peter (1)
- Hilligardt, Deborah (1)
- Hingamp, Pascal (1)
- Hoey, Andrew (1)
- Hoffmann, Franziska (1)
- Hofgaard, Annika (1)
- Hogervorst, Frans B. L. (1)
- Hohenauer, Tobias (1)
- Holeck, Kristen (1)
- Holle, Julia (1)
- Holleczek, Bernd (1)
- Hollister, Robert D. (1)
- Holmes, Richard (1)
- Holt, Patrick G. (1)
- Holzer, Ursula (1)
- Homuth, Georg (1)
- Honisch, Ellen (1)
- Hoogenboom, Mia (1)
- Hooning, Maartje J. (1)
- Hopper, John L. (1)
- Horak, Elisabeth (1)
- Horneber, Markus (1)
- Horneff, Gerd (1)
- Horvath, Judit (1)
- Hothorn, Torsten (1)
- Houtsmuller, Adriaan B. (1)
- Howell, Tony (1)
- Hsieh, Chih-hao (1)
- Hubbell, Stephen P. (1)
- Huberle, Christina (1)
- Hudson, Thomas J. (1)
- Huerta-Cepas, Jaime (1)
- Huettmann, Falk (1)
- Huffard, Christine L. (1)
- Hugo, Christian (1)
- Hunzelmann, Nico (1)
- Huo, Dezheng (1)
- Huppertz, Hans-Iko (1)
- Hurlbert, Allen H. (1)
- Håkansson, Niclas (1)
- Höbel, Sabrina (1)
- Höcht, Stefan (1)
- Hölscher, Tobias (1)
- Hönig, Manfred (1)
- Hübbel, Verena (1)
- Hübner, Norbert (1)
- Hülsmann, Brigitte (1)
- Icke, Katja (1)
- Illmann, Mona L. (1)
- Inskip, Hazel M. (1)
- Irmler, Martin (1)
- Ito, Hidemi (1)
- Ivanauskas, Natália Macedo (1)
- Iwasaki, Motoki (1)
- Iñiguez, Carmen (1)
- Jablonka, Alexandra (1)
- Jackson, Janet R. (1)
- Jaddoe, Vincent W. V. (1)
- Jahn, Martin T. (1)
- Jahns, Roland (1)
- Jakob, Waltraud (1)
- Jakoby, Donate (1)
- Jakubowska, Anna (1)
- James, Alan (1)
- Jandeleit-Dahm, Karin (1)
- Jandt, Ute (1)
- Janík, David (1)
- Jażdżewska, Anna (1)
- Johannessen, Tore (1)
- John, Esther M. (1)
- Johnstone, Jill (1)
- Jones, Emma (1)
- Jones, Faith A. M. (1)
- Jones, Julia (1)
- Jung, Audrey (1)
- Kaaks, Rudolf (1)
- Kabesch, Michael (1)
- Kaiser-Labusch, Petra (1)
- Kamitz, Dirk (1)
- Kammerbauer, Claudia (1)
- Kang, Daehee (1)
- Kang, Jungwon (1)
- Kanz, Lothar (1)
- Kapoor, Pooja Middha (1)
- Karch, André (1)
- Kartawijaya, Tasrif (1)
- Katzke, Verena (1)
- Keeley, Erin C. (1)
- Keizer, Veer I. P. (1)
- Kelleher, Cecily C. (1)
- Kellner, Nils (1)
- Kelt, Douglas A. (1)
- Kerkau, Thomas (1)
- Kerkhof, Marjan (1)
- Keupp, Katharina (1)
- Khusnutdinova, Elza (1)
- Kieseier, Bernd (1)
- Kim, Sung-Won (1)
- Kindle, Gerhard (1)
- Kinnear, Rebecca (1)
- Kirschner, Jürgen (1)
- Kitahara, Cari M. (1)
- Kitching, Roger L. (1)
- Klanderud, Kari (1)
- Klasen, Jessica (1)
- Klaus, Schwarz (1)
- Klein, Ariane (1)
- Klein, Christoph (1)
- Kleinschnitz, Christoph (1)
- Klemann, Christian (1)
- Klopstock, Thomas (1)
- Kluttig, Alexander (1)
- Knutsen, Halvor (1)
- Kobbe, Robin (1)
- Koch, Martina (1)
- Kocoski, Vladimir (1)
- Koenig, Christopher C. (1)
- Kogevinas, Manolis (1)
- Koppelman, Gerard H. (1)
- Kortz, Alessandra R. (1)
- Koutros, Stella (1)
- Kramm, Christof (1)
- Kreiner-Møller, Eskil (1)
- Kremer, Marcus (1)
- Krist, Lilian (1)
- Kristensen, Vessela N. (1)
- Krummenacher, Ivo (1)
- Král, Kamil (1)
- Krämer, Bernhard K. (1)
- Krüger, Bernd (1)
- Krüger, Renate (1)
- Krüger, William (1)
- Kubisch, Christian (1)
- Kuehni, Claudia E. (1)
- Kuhnz, Linda A. (1)
- Kullmann, Silke (1)
- Kulozik, Andreas E. (1)
- Kultima, Jens Roat (1)
- Kunz, Meik (1)
- Kuo, Chao-Yang (1)
- Kushner, David J. (1)
- Kwong, Ava (1)
- König, Ramona (1)
- Kötter, Ina (1)
- Kühnle, Ingrid (1)
- Küpers, Leanne K. (1)
- Laguionie-Marchais, Claire (1)
- Lambrechts, Diether (1)
- Lamers, Beate (1)
- Lamprecht, Peter (1)
- Lancaster, Lesley T. (1)
- Lancz, Kinga (1)
- Langemeyer, Vanessa (1)
- Laprise, Catherine (1)
- Lara-Villacanas, Eusebia (1)
- Larsen, Pernille S. (1)
- Lassy, Lisa (1)
- Laws, Hans-Juergen (1)
- Le Marchand, Loic (1)
- Lee, Cheol Min (1)
- Lee, Jae-Yun (1)
- Lee, Young Ae (1)
- Lefcheck, Jonathan S. (1)
- Lehmberg, Kai (1)
- Leierer, Johannes (1)
- Leitzmann, Michael (1)
- Leponce, Maurice (1)
- Lesch, Klaus-Peter (1)
- Lewinsohn, Thomas M. (1)
- Li, Jin (1)
- Li, Jingmei (1)
- Li, Qinghong (1)
- Li, Simone S. (1)
- Lichey, Nadine (1)
- Lichtenberg, Artur (1)
- Lichtenberg, Crispin (1)
- Liese, Johannes G. (1)
- Lightfoot, David (1)
- Lindemann, Monika (1)
- Lindström, Sara (1)
- Linet, Martha (1)
- Link, Hartmut (1)
- Lloret, Francisco (1)
- Lloyd, John D. (1)
- Lo, Wing-Yee (1)
- Lohse, Martin J. (1)
- Long, Jirong (1)
- Lophatananon, Artitaya (1)
- Loureiro Fernandes, Luiz (1)
- Louzao, Maite (1)
- Lovric, Svjetlana (1)
- Lubiński, Jan (1)
- Ludvigsson, Johnny (1)
- Lévesque, Esther (1)
- López-Baucells, Adrià (1)
- Maatouk, Imad (1)
- Maccari, Maria E. (1)
- Madin, Joshua S. (1)
- Magaritte-Jeannin, Patricia (1)
- Magnússon, Borgþór (1)
- Magurran, Anne E. (1)
- Maier, Florian (1)
- Maistrenko, Oleksandr M. (1)
- Malamud, Shahar (1)
- Mannermaa, Arto (1)
- Manoochehri, Mehdi (1)
- Manoukian, Siranoush (1)
- Marchetto, Helder (1)
- Marenholz, Ingo (1)
- Margolin, Sara (1)
- Marks, Guy B. (1)
- Martin, Nicholas G. (1)
- Martinez, Elena (1)
- Maschmeyer, Georg (1)
- Masjosthusmann, Katja (1)
- Matanovic, Anja (1)
- Matheson, Melanie C. (1)
- Matsuo, Keitaro (1)
- Matthews, Iain (1)
- Mattock, James (1)
- Mauch, Cornelia (1)
- Mavroudis, Dimitris (1)
- McArdle, Wendy (1)
- McFarland, Kent P. (1)
- McGill, Brian (1)
- McKnight, Diane (1)
- McLarney, William O. (1)
- Meador, Jason (1)
- Medianero, Enrique (1)
- Meier, Florian MP (1)
- Melén, Erik (1)
- Mende, Daniel R (1)
- Menon, Usha (1)
- Merzenich, Hiltrud (1)
- Meserve, Peter L. (1)
- Metcalfe, Daniel J. (1)
- Metzler, Claudia (1)
- Metzler, Markus (1)
- Meurer, Michael (1)
- Meurer, Sabine (1)
- Meuth, Sven G. (1)
- Meyer, Christoph F. J. (1)
- Michel, Sven (1)
- Michels, Karin B. (1)
- Michelsen, Anders (1)
- Mielke, Gudrun (1)
- Mikolajczyk, Rafael (1)
- Milanese, Alessio (1)
- Milchakova, Nataliya (1)
- Milne, Roger L. (1)
- Mitchell, Alex L (1)
- Mitesser, Oliver (1)
- Mittal, Manish (1)
- Mock, Thomas (1)
- Moens, Tom (1)
- Mohd Taib, Nur Aishah (1)
- Mohr, Michael (1)
- Moland, Even (1)
- Mommers, Monique (1)
- Montgomery, Grant W. (1)
- Moodley, Yoshan (1)
- Moore, Jon (1)
- Morbach, Henner (1)
- Moreira, Carolina Mathias (1)
- Moreno Velásquez, Ilais (1)
- Morin, Charles (1)
- Morinère, Jérôme (1)
- Mousset, Sabine (1)
- Moyes, Faye (1)
- Muir, Kenneth (1)
- Mulligan, Anna Marie (1)
- Murphy, Grace (1)
- Musk, Bill (1)
- Myers-Smith, Isla H. (1)
- Myster, Randall W. (1)
- Müglich, Carmen (1)
- Mühlfeld, Anja (1)
- Müller, Anna H. (1)
- Müller, Arndt-Christian (1)
- Müller, Christiane (1)
- Müller, Ingo (1)
- Müller, Justus (1)
- Müller, Thomas G. (1)
- Müller, Tobias (1)
- Müller-Ladner, Ulf (1)
- Müller-Thomas, Catharina (1)
- Münstermann, Esther (1)
- Narakusumo, Raden Pramesa (1)
- Naumann-Bartsch, Nora (1)
- Naumov, Andrew (1)
- Neat, Francis (1)
- Nelson, James A. (1)
- Nelson, Michael Paul (1)
- Ness, Thomas (1)
- Neubert, Jennifer (1)
- Neuhausen, Susan L. (1)
- Neumann, Silke (1)
- Nevanlinna, Heli (1)
- Neven, Patrick (1)
- Newman, William G. (1)
- Newton, Stephen F. (1)
- Niederacher, Dieter (1)
- Niehoff, Peter (1)
- Niehues, Tim (1)
- Nikolaev, Viacheslav O. (1)
- Norden, Natalia (1)
- Novotny, Vojtech (1)
- Nöthen, Markus M. (1)
- Nürnberg, Peter (1)
- Obi, Nadia (1)
- Offit, Kenneth (1)
- Ogorodova, Ludmila M. (1)
- Oliver, Jeffrey C. (1)
- Olopade, Olufunmilayo I. (1)
- Olsen, Esben M. (1)
- Olshan, Andrew F. (1)
- Olson, Janet E. (1)
- Olsson, Håkan (1)
- Onipchenko, Vladimir G. (1)
- Oommen, Prasad T. (1)
- Orivel, Jerome (1)
- Ostermann, Helmut (1)
- Otto, Christoph (1)
- Pabis, Krzysztof (1)
- Pabst, Robert J. (1)
- Palkovicova, Lubica (1)
- Palm, Dieter (1)
- Pan, Yuanlong (1)
- Panse, Jens (1)
- Paoli, Lucas (1)
- Paquette, Alain (1)
- Pardede, Sinta (1)
- Park, Sue K. (1)
- Park-Simon, Tjoung-Won (1)
- Paterson, David M. (1)
- Paul, Victoria (1)
- Peggie, Djunijanti (1)
- Peitz, Joachim (1)
- Penack, Olaf (1)
- Pennel, Craig E. (1)
- Pernitzsch, Sandy Ramona (1)
- Pershagen, Göran (1)
- Peschel, Christian (1)
- Peterlongo, Peter (1)
- Peto, Julian (1)
- Peñuelas, Josep (1)
- Pharaoh, Paul D. P. (1)
- Pike, Katherine C. (1)
- Pinkawa, Michael (1)
- Pischon, Tobias (1)
- Pizarro, Oscar (1)
- Pizzi, Constanza (1)
- Plaseska-Karanfilska, Dijana (1)
- Platzbecker, Uwe (1)
- Pohl, Esther (1)
- Pohl-Rescigno, Esther (1)
- Polanska, Kinga (1)
- Pollet, Marc (1)
- Pollinger, Florian (1)
- Pomati, Francesco (1)
- Porta, Daniela (1)
- Poschmann, Gereon (1)
- Post, Eric (1)
- Postma, Dirkje S. (1)
- Prelog, Martina (1)
- Presneau, Nadege (1)
- Prins, Herbert H. T. (1)
- Prins, Jurrien (1)
- Priscu, John C. (1)
- Provoost, Pieter (1)
- Prudic, Kathleen L. (1)
- Przybylski, Grzegorz K. (1)
- Pulliainen, Erkki (1)
- Puzyrev, Valery P. (1)
- Pélissier, Raphaël (1)
- Pérez-Matus, Alejandro (1)
- Rack, Brigitte (1)
- Rack-Hoch, Anita (1)
- Rad, Roland (1)
- Radice, Paolo (1)
- Ramesh, B. R. (1)
- Ramos, Olivia Mendivil (1)
- Ramser, Juliane (1)
- Rapp, Mathieu (1)
- Rascle, Anne (1)
- Rashid, Muhammad U. (1)
- Rassweiler, Andrew (1)
- Rebelo, Jose Eduardo (1)
- Redlich, Sarah (1)
- Reed, Daniel C. (1)
- Reich, Kristian (1)
- Reich, Peter B. (1)
- Reinhold, Thomas (1)
- Remillard, Suzanne M. (1)
- Renders, Lutz (1)
- Rennert, Gad (1)
- Rennert, Hedy S. (1)
- Rhiem, Kerstin (1)
- Ribeiro, Servio P. (1)
- Richardson, Anthony J. (1)
- Richardson, J. Paul (1)
- Richiardi, Lorenzo (1)
- Rieber, Nikolaus (1)
- Riebl, Rebekka (1)
- Rieger, Christina (1)
- Rietschel, Ernst (1)
- Ritterbusch, Henrike (1)
- Rivera-Monroy, Victor H. (1)
- Rixen, Christian (1)
- Roberts, Graham (1)
- Robertson, Colin F. (1)
- Robinson, Kevin P. (1)
- Rocha, Ricardo (1)
- Rockstroh, Jürgen K. (1)
- Rodrigues, Ricardo Ribeiro (1)
- Rodriguez, Elke (1)
- Roehrig, Florian (1)
- Roesler, Joachim (1)
- Roisin, Yves (1)
- Rojas-Botero, Sandra (1)
- Romero, Atocha (1)
- Rondak, Ina-Christine (1)
- Rosenfeldt, Mathias T. (1)
- Rosenwald, Andreas (1)
- Roslin, Tomas (1)
- Rothenfusser, Simon (1)
- Roubik, David W. (1)
- Rubbert-Roth, Andrea (1)
- Ruckert, Christian (1)
- Rudelius, Martina (1)
- Rudstam, Lars (1)
- Ruebner, Matthias (1)
- Ruhl, Henry (1)
- Ruhnke, Markus (1)
- Rummler, Thomas (1)
- Rump, Andreas (1)
- Rusch, Stephan (1)
- Ruscheweyh, Hans-Joachim (1)
- Ruz, Catalina S. (1)
- Ruzicka, Thomas (1)
- Rybicki, Nancy (1)
- Rypel, Andrew (1)
- Rösen-Wolff, Angela (1)
- Rüschendorf, Franz (1)
- Sal, Sofia (1)
- Salazar, Guillem (1)
- Salgado, Beatriz (1)
- Saloustros, Emmanouil (1)
- Sampaio, Erica M. (1)
- Sander, Dirk (1)
- Santos, Flavio A. M. (1)
- Savassi-Coutinho, Ana Paula (1)
- Scanga, Sara (1)
- Schaaf, Marcel J. M. (1)
- Schanz, Julie (1)
- Schauer, Uwe (1)
- Scheer, Ulrich (1)
- Scheibenbogen, Carmen M. (1)
- Scheible, Raphael (1)
- Schikowski, Tamara (1)
- Schindler, Detlev (1)
- Schipf, Sabine M. (1)
- Schlipp, Angela (1)
- Schmalzing, Marc T. (1)
- Schmidberger, Heinz (1)
- Schmidl, Jürgen (1)
- Schmidt, Andreas (1)
- Schmidt, Anne (1)
- Schmidt, Burkard (1)
- Schmidt, Carsten O. (1)
- Schmidt, Christian A. (1)
- Schmidt, Doris (1)
- Schmidt, Elvira (1)
- Schmidt, Erwin (1)
- Schmidt, Gunnar (1)
- Schmidt, Harald H. H. W. (1)
- Schmidt, Jesper B. (1)
- Schmidt, Jochen (1)
- Schmidt, Katrin (1)
- Schmidt, Marcus (1)
- Schmidt, Marjanka K. (1)
- Schmidt, Martina E. (1)
- Schmidt, Nadine (1)
- Schmidt, Reinhold E. (1)
- Schmidt, Thomas Christian (1)
- Schmidt, Thomas P. (1)
- Schmidt, Thomas S. (1)
- Schmidt, Thomas Sebastian Benedikt (1)
- Schmidt, Timo (1)
- Schmidt, Traudel (1)
- Schmidt, Uwe (1)
- Schmidt, Vanessa (1)
- Schmidt, Wolfgang A. (1)
- Schmidt-Hegemann, Nina-Sophie (1)
- Schmidt-Hieber, Martin (1)
- Schmitt, Stefan (1)
- Schneider, Christoph (1)
- Schneider, Dominik T. (1)
- Schneider, Gisbert (1)
- Schneider, Michael O. (1)
- Schneider, Valentin (1)
- Schoemaker, Minouk J. (1)
- Schooley, Robert (1)
- Schrader, Jürgen (1)
- Schramm, Sara (1)
- Schreiber, Stefan (1)
- Schrewe, Anja (1)
- Schröter, Marleen (1)
- Schubert, Ralf (1)
- Schuelein-Voelk, Christina (1)
- Schuhmann, Michael K. (1)
- Schulz, Ansgar (1)
- Schulz, Claudia (1)
- Schulze, Matthias B. (1)
- Schulze-Koops, Hendrik (1)
- Schwaneck, Eva C. (1)
- Schwarting, Andreas (1)
- Schwarz, Tobias (1)
- Schwarz-Eywill, Michael (1)
- Schwarze-Zander, Carolynne (1)
- Schweigerer, Lothar (1)
- Schwentner, Lukas (1)
- Schäfer, Marius (1)
- Schöll, Achim (1)
- Schön, Michael P. (1)
- Schönberger, Stefan (1)
- Schürmann, Gesine (1)
- Scott, Christopher (1)
- Sedlmayer, Felix (1)
- Sedlmeier, Anja (1)
- Seibold, Sebastian (1)
- Senft, Daniela (1)
- Setiawan, Fakhrizal (1)
- Shah, Ajay M. (1)
- Shai, Sonu (1)
- Shao, Kwang-Tsao (1)
- Shaver, Gaius R. (1)
- Shen, Chen-Yang (1)
- Sherman, Sally (1)
- Sherry, Thomas W. (1)
- Shu, Xiao-Ou (1)
- Siciński, Jacek (1)
- Siegwart Collier, Laura (1)
- Sievers, Caya (1)
- Silling, Gerda (1)
- Silveira, Fabio L. (1)
- Simard, Jaques (1)
- Slager, Susan (1)
- Sleiman, Patrick (1)
- Slingsby, Jasper (1)
- Sly, Peter D. (1)
- Smart, Tracey (1)
- Smichkoska, Snezhana (1)
- Smogavec, Mateja (1)
- Snell, Sara J. (1)
- Sobhani, Iradj (1)
- Sobik, Bettina (1)
- Soetedjo, Veronika (1)
- Sogkas, Georgios (1)
- Sollinger, Franz M. (1)
- Sommerer, Claudia (1)
- Sonnenschein-van der Voort, Agnes M. M. (1)
- Soudzilovskaia, Nadejda A. (1)
- Southey, Melissa C. (1)
- Souza, Flaviana Maluf (1)
- Souza, Gabriel B. G. (1)
- Souza, Vinícius Castro (1)
- Speckmann, Carsten (1)
- Spinelli, John J. (1)
- Spycher, Ben D. (1)
- Sram, Radim J. (1)
- Stadler, Christoph (1)
- Stadler, Rudolf (1)
- Stallings, Christopher D. (1)
- Stanforth, Rowan (1)
- Stanley, Emily H. (1)
- Steckel, Bodo (1)
- Steffan-Dewenter, Ingolf (1)
- Steffenhagen, Thomas (1)
- Steindorf, Karen (1)
- Steinmann, Sandra (1)
- Sterza, José Mauro (1)
- Steubl, Dominik (1)
- Stevens, Maarten (1)
- Stiefel, Martina (1)
- Stoll, Guido (1)
- Stone, Jennifer (1)
- Strachan, David P. (1)
- Strutz, Frank (1)
- Stuart-Smith, Rick (1)
- Stühler, Kai (1)
- Suarez, Yzel Rondon (1)
- Sunderkötter, Cord (1)
- Sunyer, Jordi (1)
- Supp, Sarah (1)
- Surowy, Harald (1)
- Sutter, Christian (1)
- Swerdlow, Anthony J. (1)
- Sääf, Annika (1)
- Söderhäll, Cilla (1)
- Sörensen, Helmut (1)
- Sørensen, Line (1)
- Südhoff, Thomas (1)
- Tamashiro, Jorge Yoshio (1)
- Tamimi, Rulla M. (1)
- Tanoey, Justine (1)
- Tapper, William J. (1)
- Tarigan, Sukmaraharja (1)
- Tegtmeyer, Nicole (1)
- Teismann, Henning (1)
- Temme, Sebastian (1)
- Tenbrock, Klaus (1)
- Teo, Soo H. (1)
- Terry, Mary Beth (1)
- Thiede, Gary P. (1)
- Thiele, Holger (1)
- Thijs, Carel (1)
- Thompson, Philip J. (1)
- Tian, Zhen (1)
- Tietsch, Nadine (1)
- Tishechkin, Alexey K. (1)
- Tobisch, Cynthia (1)
- Toland, Amanda E. (1)
- Tollenaar, Rob A. E. M. (1)
- Tolvanen, Anne (1)
- Toniato, Maria Teresa Zugliani (1)
- Torrent, Maties (1)
- Torres, Diana (1)
- Torres, Javier (1)
- Torres-Mejía, Gabriela (1)
- Toskala, Elina (1)
- Totland, Ørjan (1)
- Traidl‐Hoffmann, Claudia (1)
- Traverso, Francisco Rivas (1)
- Troester, Melissa A. (1)
- Truong, Thérèse (1)
- Tsugane, Shoichiro (1)
- Turini Farah, Fabiano (1)
- Twilley, Robert R. (1)
- Ubaidillah, Rosichon (1)
- Uhler, Johannes (1)
- Ullmann, Andrew J. (1)
- Ullrich, Stefan (1)
- Umbach, Eberhard (1)
- Unger, Leonore (1)
- Untch, Michael (1)
- Uphus, Lars (1)
- Uttinger, Konstantin (1)
- Vachon, Celine M. (1)
- Vaitkus, Gediminas (1)
- Valdivia, Nelson (1)
- Vallejo, Martha Isabel (1)
- Valone, Thomas J. (1)
- Van Colen, Carl (1)
- Van Hoey, Gert (1)
- Vanaverbeke, Jan (1)
- Vargas, Alfredo (1)
- Veelken, Roland (1)
- Venturoli, Fabio (1)
- Verheye, Hans M. (1)
- Versmold, Beatrix (1)
- Vianna, Marcelo (1)
- Vieira, Rui P. (1)
- Viemann, Dorothee (1)
- Vijai, Joseph (1)
- Viljoen, Karien (1)
- Vinnemeier-Laubenthal, Elisabeth (1)
- Voigt, Anita Y. (1)
- Volk, Alexander E. (1)
- Vrdoljak, Pavo (1)
- Vrijheid, Martine (1)
- Vrška, Tomáš (1)
- Vu, Con Quang (1)
- Vu, Lien Van (1)
- Völzke, Henry (1)
- Wagner, Norbert (1)
- Wagner, Ralf (1)
- Waide, Robert B. (1)
- Waldock, Conor (1)
- Wang, Qin (1)
- Wang-Gohrke, Shan (1)
- Wappenschmidt, Barbara (1)
- Warnatz, Klaus (1)
- Wasmuth, Jan-Christian (1)
- Wassenberg, Siegfried (1)
- Watts, Dave (1)
- Webb, Sara (1)
- Weber, Bernhard H. F. (1)
- Weber, Katharina S. (1)
- Weber, Thomas (1)
- Weber-Lassalle, Konstantin (1)
- Weber-Lassalle, Nana (1)
- Weidinger, Stefan (1)
- Weinerth, Jutta (1)
- Weissmann, Norbert (1)
- Weiß, Michael (1)
- Wekerle, Thomas (1)
- Wendt, Camilla (1)
- Werfel, Thomas (1)
- Wesołowski, Tomasz (1)
- Wessler, Silja (1)
- Westkemper, Marco (1)
- Westphal, Jens (1)
- White, Ethan P. (1)
- Widdicombe, Claire E. (1)
- Wiendl, Heinz (1)
- Wijga, Alet H. (1)
- Wilgers, Dustin (1)
- Williams, Richard (1)
- Williams, Stefan B. (1)
- Williamson, Mark (1)
- Willich, Stefan N. (1)
- Willig, Michael R. (1)
- Willis, Trevor J. (1)
- Wilmes, Paul (1)
- Wilsman‐Theis, Dagmar (1)
- Winchester, Neville N. (1)
- Wingler, Kirstin (1)
- Wipf, Sonja (1)
- Wirbel, Jakob (1)
- Wittke, Kirsten (1)
- Wittkowski, Helmut (1)
- Witzke, Oliver (1)
- Woeckel, Achim (1)
- Woehler, Eric J. (1)
- Wolf, Elmar (1)
- Wolf, Frank (1)
- Wolf, Hans-Heinrich (1)
- Wolk, Alicja (1)
- Wollschläger, Daniel (1)
- Woods, Kerry D. (1)
- Worm, Margitta (1)
- Wölke, Sandra (1)
- Yamaoka, Yoshio (1)
- Yeoh, Khay Guan (1)
- Yu, Jyh-Cherng (1)
- Zamboglou, Constantinos (1)
- Zawada, Kyle (1)
- Zettl, Uwe (1)
- Zettler, Michael L. (1)
- Zeuner, Rainald (1)
- Zhang, Jie (1)
- Zheng, Wei (1)
- Zielen, Stefan (1)
- Ziemann, Ulf (1)
- Zimmermann, Antje (1)
- Ziogas, Argyrios (1)
- Zips, Daniel (1)
- Ziv, Elad (1)
- Zwanzger, Peter (1)
- da Rocha, Wesley Duarte (1)
- da Silva, Ana Carolina (1)
- da Silva, Fernando Rodrigues (1)
- de Angelis, Martin Hrabe (1)
- de Araujo, Bruno Cancian (1)
- de Beaufort, Carine (1)
- de Cerqueira Rossa-Feres, Denise (1)
- de Kloet, E. Ron (1)
- de Oliveira, Evandro Gama (1)
- dos-Santos-Silva, Isabel (1)
- van Rijn, Itai (1)
- van Royen, Martin E. (1)
- van Veen, Elke M. (1)
- van den Ouweland, Ans M. W. (1)
- van der Ent, C. Kors (1)
- van der Gugten, Anne C. (1)
- von Rintelen, Kristina (1)
- von Rintelen, Thomas (1)
- von Wussow, Praxis (1)
- Ødegaard, Frode (1)
- Ülzen, Anett (1)
Institute
- Theodor-Boveri-Institut für Biowissenschaften (13)
- Medizinische Klinik und Poliklinik II (5)
- Institut für Klinische Epidemiologie und Biometrie (4)
- Pathologisches Institut (3)
- Institut für Humangenetik (2)
- Institut für Virologie und Immunbiologie (2)
- Kinderklinik und Poliklinik (2)
- Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) (2)
- Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie (2)
- Neurologische Klinik und Poliklinik (2)
Temme, Sebastian ; Friebe, Daniela ; Schmidt, Timo ; Poschmann, Gereon ; Hesse, Julia ; Steckel, Bodo ; Stühler, Kai ; Kunz, Meik ; Dandekar, Thomas ; Ding, Zhaoping ; Akhyari, Payam ; Lichtenberg, Artur ; Schrader, Jürgen
Epicardium-derived cells (EPDC) and atrial stromal cells (ASC) display cardio-regenerative potential, but the molecular details are still unexplored. Signals which induce activation, migration and differentiation of these cells are largely unknown. Here we have isolated rat ventricular EPDC and rat/human ASC and performed genetic and proteomic profiling. EPDC and ASC expressed epicardial/mesenchymal markers (WT-1, Tbx18, CD73,CD90, CD44, CD105), cardiac markers (Gata4, Tbx5, troponin T) and also contained phosphocreatine. We used cell surface biotinylation to isolate plasma membrane proteins of rEPDC and hASC, Nano-liquid chromatography with subsequent mass spectrometry and bioinformatics analysis identified 396 rat and 239 human plasma membrane proteins with 149 overlapping proteins. Functional GO-term analysis revealed several significantly enriched categories related to extracellular matrix (ECM), cell migration/differentiation, immunology or angiogenesis. We identified receptors for ephrin and growth factors (IGF, PDGF, EGF, anthrax toxin) known to be involved in cardiac repair and regeneration. Functional category enrichment identified clusters around integrins, PI3K/Akt-signaling and various cardiomyopathies. Our study indicates that EPDC and ASC have a similar molecular phenotype related to cardiac healing/regeneration. The cell surface proteome repository will help to further unravel the molecular details of their cardio-regenerative potential and their role in cardiac diseases.
Tanoey, Justine ; Baechle, Christina ; Brenner, Hermann ; Deckert, Andreas ; Fricke, Julia ; Günther, Kathrin ; Karch, André ; Keil, Thomas ; Kluttig, Alexander ; Leitzmann, Michael ; Mikolajczyk, Rafael ; Obi, Nadia ; Pischon, Tobias ; Schikowski, Tamara ; Schipf, Sabine M. ; Schulze, Matthias B. ; Sedlmeier, Anja ; Moreno Velásquez, Ilais ; Weber, Katharina S. ; Völzke, Henry ; Ahrens, Wolfgang ; Gastell, Sylvia ; Holleczek, Bernd ; Jöckel, Karl-Heinz ; Katzke, Verena ; Lieb, Wolfgang ; Michels, Karin B. ; Schmidt, Börge ; Teismann, Henning ; Becher, Heiko
(1) Background: Global incidence of type 1 diabetes (T1D) is rising and nearly half occurred in adults. However, it is unclear if certain early-life childhood T1D risk factors were also associated with adult-onset T1D. This study aimed to assess associations between birth order, delivery mode or daycare attendance and type 1 diabetes (T1D) risk in a population-based cohort and whether these were similar for childhood- and adult-onset T1D (cut-off age 15); (2) Methods: Data were obtained from the German National Cohort (NAKO Gesundheitsstudie) baseline assessment. Self-reported diabetes was classified as T1D if: diagnosis age ≤ 40 years and has been receiving insulin treatment since less than one year after diagnosis. Cox regression was applied for T1D risk analysis; (3) Results: Analyses included 101,411 participants (100 childhood- and 271 adult-onset T1D cases). Compared to “only-children”, HRs for second- or later-born individuals were 0.70 (95% CI = 0.50–0.96) and 0.65 (95% CI = 0.45–0.94), respectively, regardless of parental diabetes, migration background, birth year and perinatal factors. In further analyses, higher birth order reduced T1D risk in children and adults born in recent decades. Caesarean section and daycare attendance showed no clear associations with T1D risk; (4) Conclusions: Birth order should be considered in both children and adults’ T1D risk assessment for early detection.
Dörk, Thilo ; Peterlongo, Peter ; Mannermaa, Arto ; Bolla, Manjeet K. ; Wang, Qin ; Dennis, Joe ; Ahearn, Thomas ; Andrulis, Irene L. ; Anton-Culver, Hoda ; Arndt, Volker ; Aronson, Kristan J. ; Augustinsson, Annelie ; Beane Freeman, Laura E. ; Beckmann, Matthias W. ; Beeghly-Fadiel, Alicia ; Behrens, Sabine ; Bermisheva, Marina ; Blomqvist, Carl ; Bogdanova, Natalia V. ; Bojesen, Stig E. ; Brauch, Hiltrud ; Brenner, Hermann ; Burwinkel, Barbara ; Canzian, Federico ; Chan, Tsun L. ; Chang-Claude, Jenny ; Chanock, Stephen J. ; Choi, Ji-Yeob ; Christiansen, Hans ; Clarke, Christine L. ; Couch, Fergus J. ; Czene, Kamila ; Daly, Mary B. ; dos-Santos-Silva, Isabel ; Dwek, Miriam ; Eccles, Diana M. ; Ekici, Arif B. ; Eriksson, Mikael ; Evans, D. Gareth ; Fasching, Peter A. ; Figueroa, Jonine ; Flyger, Henrik ; Fritschi, Lin ; Gabrielson, Marike ; Gago-Dominguez, Manuela ; Gao, Chi ; Gapstur, Susan M. ; García-Closas, Montserrat ; García-Sáenz, José A. ; Gaudet, Mia M. ; Giles, Graham G. ; Goldberg, Mark S. ; Goldgar, David E. ; Guenél, Pascal ; Haeberle, Lothar ; Haimann, Christopher A. ; Håkansson, Niclas ; Hall, Per ; Hamann, Ute ; Hartman, Mikael ; Hauke, Jan ; Hein, Alexander ; Hillemanns, Peter ; Hogervorst, Frans B. L. ; Hooning, Maartje J. ; Hopper, John L. ; Howell, Tony ; Huo, Dezheng ; Ito, Hidemi ; Iwasaki, Motoki ; Jakubowska, Anna ; Janni, Wolfgang ; John, Esther M. ; Jung, Audrey ; Kaaks, Rudolf ; Kang, Daehee ; Kapoor, Pooja Middha ; Khusnutdinova, Elza ; Kim, Sung-Won ; Kitahara, Cari M. ; Koutros, Stella ; Kraft, Peter ; Kristensen, Vessela N. ; Kwong, Ava ; Lambrechts, Diether ; Le Marchand, Loic ; Li, Jingmei ; Lindström, Sara ; Linet, Martha ; Lo, Wing-Yee ; Long, Jirong ; Lophatananon, Artitaya ; Lubiński, Jan ; Manoochehri, Mehdi ; Manoukian, Siranoush ; Margolin, Sara ; Martinez, Elena ; Matsuo, Keitaro ; Mavroudis, Dimitris ; Meindl, Alfons ; Menon, Usha ; Milne, Roger L. ; Mohd Taib, Nur Aishah ; Muir, Kenneth ; Mulligan, Anna Marie ; Neuhausen, Susan L. ; Nevanlinna, Heli ; Neven, Patrick ; Newman, William G. ; Offit, Kenneth ; Olopade, Olufunmilayo I. ; Olshan, Andrew F. ; Olson, Janet E. ; Olsson, Håkan ; Park, Sue K. ; Park-Simon, Tjoung-Won ; Peto, Julian ; Plaseska-Karanfilska, Dijana ; Pohl-Rescigno, Esther ; Presneau, Nadege ; Rack, Brigitte ; Radice, Paolo ; Rashid, Muhammad U. ; Rennert, Gad ; Rennert, Hedy S. ; Romero, Atocha ; Ruebner, Matthias ; Saloustros, Emmanouil ; Schmidt, Marjanka K. ; Schmutzler, Rita K. ; Schneider, Michael O. ; Schoemaker, Minouk J. ; Scott, Christopher ; Shen, Chen-Yang ; Shu, Xiao-Ou ; Simard, Jaques ; Slager, Susan ; Smichkoska, Snezhana ; Southey, Melissa C. ; Spinelli, John J. ; Stone, Jennifer ; Surowy, Harald ; Swerdlow, Anthony J. ; Tamimi, Rulla M. ; Tapper, William J. ; Teo, Soo H. ; Terry, Mary Beth ; Toland, Amanda E. ; Tollenaar, Rob A. E. M. ; Torres, Diana ; Torres-Mejía, Gabriela ; Troester, Melissa A. ; Truong, Thérèse ; Tsugane, Shoichiro ; Untch, Michael ; Vachon, Celine M. ; van den Ouweland, Ans M. W. ; van Veen, Elke M. ; Vijai, Joseph ; Wendt, Camilla ; Wolk, Alicja ; Yu, Jyh-Cherng ; Zheng, Wei ; Ziogas, Argyrios ; Ziv, Elad ; Dunnig, Alison ; Pharaoh, Paul D. P. ; Schindler, Detlev ; Devilee, Peter ; Easton, Douglas F.
Fanconi anemia (FA) is a genetically heterogeneous disorder with 22 disease-causing genes reported to date. In some FA genes, monoallelic mutations have been found to be associated with breast cancer risk, while the risk associations of others remain unknown. The gene for FA type C, FANCC, has been proposed as a breast cancer susceptibility gene based on epidemiological and sequencing studies. We used the Oncoarray project to genotype two truncating FANCC variants (p.R185X and p.R548X) in 64,760 breast cancer cases and 49,793 controls of European descent. FANCC mutations were observed in 25 cases (14 with p.R185X, 11 with p.R548X) and 26 controls (18 with p.R185X, 8 with p.R548X). There was no evidence of an association with the risk of breast cancer, neither overall (odds ratio 0.77, 95%CI 0.44–1.33, p = 0.4) nor by histology, hormone receptor status, age or family history. We conclude that the breast cancer risk association of these two FANCC variants, if any, is much smaller than for BRCA1, BRCA2 or PALB2 mutations. If this applies to all truncating variants in FANCC it would suggest there are differences between FA genes in their roles on breast cancer risk and demonstrates the merit of large consortia for clarifying risk associations of rare variants.
Merzenich, Hiltrud ; Baaken, Dan ; Schmidt, Marcus ; Bekes, Inga ; Schwentner, Lukas ; Janni, Wolfgang ; Woeckel, Achim ; Bartkowiak, Detlef ; Wiegel, Thomas ; Blettner, Maria ; Wollschläger, Daniel ; Schmidberger, Heinz
Purpose
Radiotherapy (RT) was identified as a risk factor for long-term cardiac effects in breast cancer patients treated until the 1990s. However, modern techniques reduce radiation exposure of the heart, but some exposure remains unavoidable. In a retrospective cohort study, we investigated cardiac mortality and morbidity of breast cancer survivors treated with recent RT in Germany.
Methods
A total of 11,982 breast cancer patients treated between 1998 and 2008 were included. A mortality follow-up was conducted until 06/2018. In order to assess cardiac morbidity occurring after breast cancer treatment, a questionnaire was sent out in 2014 and 2019. The effect of breast cancer laterality on cardiac mortality and morbidity was investigated as a proxy for radiation exposure. We used Cox Proportional Hazards regression analysis, taking potential confounders into account.
Results
After a median follow-up time of 11.1 years, there was no significant association of tumor laterality with cardiac mortality in irradiated patients (hazard ratio (HR) for left-sided versus right-sided tumor 1.09; 95% confidence interval (CI) 0.85–1.41). Furthermore, tumor laterality was not identified as a significant risk factor for cardiac morbidity (HR = 1.05; 95%CI 0.88–1.25).
Conclusions
Even though RT for left-sided breast cancer on average incurs higher radiation dose to the heart than RT for right-sided tumors, we found no evidence that laterality is a strong risk factor for cardiac disease after contemporary RT. However, larger sample sizes, longer follow-up, detailed information on individual risk factors and heart dose are needed to assess clinically manifest late effects of current cancer therapy.
Floren, Andreas ; von Rintelen, Thomas ; Herbert, Paul D. N. ; de Araujo, Bruno Cancian ; Schmidt, Stefan ; Balke, Michael ; Narakusumo, Raden Pramesa ; Peggie, Djunijanti ; Ubaidillah, Rosichon ; von Rintelen, Kristina ; Müller, Tobias
Tropical mountain forests contribute disproportionately to terrestrial biodiversity but little is known about insect diversity in the canopy and how it is distributed between tree species. We sampled tree-specific arthropod communities from 28 trees by canopy fogging and analysed beetle communities which were first morphotyped and then identified by their DNA barcodes. Our results show that communities from forests at 1100 and 1700 m a.s.l. are almost completely distinct. Diversity was much lower in the upper forest while community structure changed from many rare, less abundant species to communities with a pronounced dominance structure. We also found significantly higher beta-diversity between trees at the lower than higher elevation forest where community similarity was high. Comparisons on tree species found at both elevations reinforced these results. There was little species overlap between sites indicating limited elevational ranges. Furthermore, we exploited the advantage of DNA barcodes to patterns of haplotype diversity in some of the commoner species. Our results support the advantage of fogging and DNA barcodes for community studies and underline the need for comprehensive research aimed at the preservation of these last remaining pristine forests.
Otto, Christoph ; Kastner, Carolin ; Schmidt, Stefanie ; Uttinger, Konstantin ; Baluapuri, Apoorva ; Denk, Sarah ; Rosenfeldt, Mathias T. ; Rosenwald, Andreas ; Roehrig, Florian ; Ade, Carsten P. ; Schuelein-Voelk, Christina ; Diefenbacher, Markus E. ; Germer, Christoph-Thomas ; Wolf, Elmar ; Eilers, Martin ; Wiegering, Armin
Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC), which constitutes the initiating event in the adenoma carcinoma sequence for colorectal cancer (CRC), induces the expression of RNA polymerase I (RNAPOL1) transcription machinery, and subsequently upregulates ribosomal DNA (rDNA) transcription. Targeting RNAPOL1 with a specific inhibitor, CX5461, disrupts nucleolar integrity, and induces a disbalance of ribosomal proteins. Surprisingly, CX5461-induced growth arrest is irreversible and exhibits features of senescence and terminal differentiation. Mechanistically, CX5461 promotes differentiation in an MYC-interacting zinc-finger protein 1 (MIZ1)- and retinoblastoma protein (Rb)-dependent manner. In addition, the inhibition of RNAPOL1 renders CRC cells vulnerable towards senolytic agents. We validated this therapeutic effect of CX5461 in murine- and patient-derived organoids, and in a xenograft mouse model. These results show that targeting ribosomal biogenesis together with targeting the consecutive, senescent phenotype using approved drugs is a new therapeutic approach, which can rapidly be transferred from bench to bedside.
Milanese, Alessio ; Mende, Daniel R ; Paoli, Lucas ; Salazar, Guillem ; Ruscheweyh, Hans-Joachim ; Cuenca, Miguelangel ; Hingamp, Pascal ; Alves, Renato ; Costea, Paul I ; Coelho, Luis Pedro ; Schmidt, Thomas S. B. ; Almeida, Alexandre ; Mitchell, Alex L ; Finn, Robert D. ; Huerta-Cepas, Jaime ; Bork, Peer ; Zeller, Georg ; Sunagawa, Shinichi
Metagenomic sequencing has greatly improved our ability to profile the composition of environmental and host-associated microbial communities. However, the dependency of most methods on reference genomes, which are currently unavailable for a substantial fraction of microbial species, introduces estimation biases. We present an updated and functionally extended tool based on universal (i.e., reference-independent), phylogenetic marker gene (MG)-based operational taxonomic units (mOTUs) enabling the profiling of >7700 microbial species. As more than 30% of them could not previously be quantified at this taxonomic resolution, relative abundance estimates based on mOTUs are more accurate compared to other methods. As a new feature, we show that mOTUs, which are based on essential housekeeping genes, are demonstrably well-suited for quantification of basal transcriptional activity of community members. Furthermore, single nucleotide variation profiles estimated using mOTUs reflect those from whole genomes, which allows for comparing microbial strain populations (e.g., across different human body sites).
Hauke, Jan ; Horvath, Judit ; Groß, Eva ; Gehrig, Andrea ; Honisch, Ellen ; Hackmann, Karl ; Schmidt, Gunnar ; Arnold, Norbert ; Faust, Ulrike ; Sutter, Christian ; Hentschel, Julia ; Wang-Gohrke, Shan ; Smogavec, Mateja ; Weber, Bernhard H. F. ; Weber-Lassalle, Nana ; Weber-Lassalle, Konstantin ; Borde, Julika ; Ernst, Corinna ; Altmüller, Janine ; Volk, Alexander E. ; Thiele, Holger ; Hübbel, Verena ; Nürnberg, Peter ; Keupp, Katharina ; Versmold, Beatrix ; Pohl, Esther ; Kubisch, Christian ; Grill, Sabine ; Paul, Victoria ; Herold, Natalie ; Lichey, Nadine ; Rhiem, Kerstin ; Ditsch, Nina ; Ruckert, Christian ; Wappenschmidt, Barbara ; Auber, Bernd ; Rump, Andreas ; Niederacher, Dieter ; Haaf, Thomas ; Ramser, Juliane ; Dworniczak, Bernd ; Engel, Christoph ; Meindl, Alfons ; Schmutzler, Rita K. ; Hahnen, Eric
The prevalence of germ line mutations in non-BRCA1/2 genes associated with hereditary breast cancer (BC) is low, and the role of some of these genes in BC predisposition and pathogenesis is conflicting. In this study, 5589 consecutive BC index patients negative for pathogenic BRCA1/2 mutations and 2189 female controls were screened for germ line mutations in eight cancer predisposition genes (ATM, CDH1, CHEK2, NBN, PALB2, RAD51C, RAD51D, and TP53). All patients met the inclusion criteria of the German Consortium for Hereditary Breast and Ovarian Cancer for germ line testing. The highest mutation prevalence was observed in the CHEK2 gene (2.5%), followed by ATM (1.5%) and PALB2 (1.2%). The mutation prevalence in each of the remaining genes was 0.3% or lower. Using Exome Aggregation Consortium control data, we confirm significant associations of heterozygous germ line mutations with BC for ATM (OR: 3.63, 95%CI: 2.67–4.94), CDH1 (OR: 17.04, 95%CI: 3.54–82), CHEK2 (OR: 2.93, 95%CI: 2.29–3.75), PALB2 (OR: 9.53, 95%CI: 6.25–14.51), and TP53 (OR: 7.30, 95%CI: 1.22–43.68). NBN germ line mutations were not significantly associated with BC risk (OR:1.39, 95%CI: 0.73–2.64). Due to their low mutation prevalence, the RAD51C and RAD51D genes require further investigation. Compared with control datasets, predicted damaging rare missense variants were significantly more prevalent in CHEK2 and TP53 in BC index patients. Compared with the overall sample, only TP53 mutation carriers show a significantly younger age at first BC diagnosis. We demonstrate a significant association of deleterious variants in the CHEK2, PALB2, and TP53 genes with bilateral BC. Both, ATM and CHEK2, were negatively associated with triple-negative breast cancer (TNBC) and estrogen receptor (ER)-negative tumor phenotypes. A particularly high CHEK2 mutation prevalence (5.2%) was observed in patients with human epidermal growth factor receptor 2 (HER2)-positive tumors.